i tng: SV ngnh Ho Dc & Dc th y

ThS. Nguyn Ngc Th Trn

TRNG I HC Y DC CN TH KHOA DC B MN BO CH

MC TIU

1/ Trnh by c nh ngha, phn loi, u

nhc im ca dung dch thuc

2/ Lit k cc thnh phn ca dung dch thuc

3/ Tm tt cc giai on iu ch dung dch thuc

4/ Phn tch v vit qui trnh iu ch mt s cng

thc thuc thng dng

NH NGHA

Dung dch thuc l ch phm lng, trong sut c

iu ch bng cch ha tan mt hay nhiu dc

cht trong mt hay mt hn hp dung mi thch hp.

PHN LOI

Theo bn cht dung mi: - Dung dch nc - Dung dch cn - Dung dch du - Dung dch glycerin

Theo cch dng: Dung dch dng ngoi Dung dch dng trong

Theo cu trc ha l: Dung dch tht Dung dch keo Dung dch gi

U, NHC IM CA DUNG DCH THUC

u im: Hp thu v tc dung nhanh hn cc dng thuc rn.

Mt s dc cht dng dung dch khng gy kch ng khi tip xc vi nim mc.

Nhc im: -Km bn, d b thy phn, oxy ha, to phc, d b nm mc, VK pht trin

-Bao gi cng knh, kh vn chuyn

THNH PHN

Hot cht: cht tan dng:

84 LOI DUNG MI CHNH

Tnh cht

Nc ct

Ethanol - Hn hp ethanol-

nc

Glycerin Du thc vt

Ho tan

T t : h p cht v c K m : hp cht hu c

Acid, kim hu c, nha, tinh du

Acid hu c, v c , alkaloid base v mui

Cc cht tan t r o n g d u : L o n g n o , menthol, tinh du, alkaloid base, vitamin A, D, E, K

Khng ho tan

Nha, cht bo, alkaloid base

Pec t i n , gm, protid, enzym

8Tnh cht

Nc ct

Ethanol - Hn hp ethanol-

nc

Glycerin Du thc vt

c im

L c h t dn tt v h n h o vi dch c th

Ph hp v i m i t r n g sinh l

D b phn h u ( l ho, VSV, nm mc)

To hn hp bt c t l no vi hn hp n c v glyceirn

Lm cht bo qun khng khun [] >10%, dung dch st trng [ ] 60 -90%

Lm dung mi c h i t x u t dc liu

G l y c e r i n khan: d ht m, gy kch ng da v nim mc

G l y c e r i n dc dng: c h a 3 % nc

[ ] > 20%: tc d n g d i t khun , g i m, bm dnh tt

Ko di s phng thch dc cht

V d: Dung dch Dalibour

ng sulfat 1g Km sulfat 4g Dd acid picric 0,1% 10 ml Cn long no 10 ml Nc ct v 1000 ml

TNH CHT V VAI TR TNG CHT 1/ ng sulfat: CuSO4. 5H2O Tinh th mu xanh l, v cht. D tan trong nc v glycerin, gn nh khng tan trong cn 95o, ngoi khng kh s dn dn mt nc. Dng ngoi c tc dng st trng. 2/ Km sulfat: ZnSO4. 7H2O Tinh th hnh lng tr hay bt kt tinh, trong sut, khng mu, khng mi, v cht st li. Rt d tan trong nc, tan chm trong glycerin, khng tan trong cn. Dung dch 0,1% - 0,5% c tc dng st trng. 3/ Dung dch acid picric 1% Dung dch mu vng, c phn ng acid. C tc dng gim au ti ch, chng ln da non.

TNH CHT CH PHM: Dung dch trong, mu, mi c trng. BO QUN: Trong chai l kn, ni mt, trnh nh sng. CNG DNG: St trng ngoi da, dng ra v p trong trng hp chm, nm.

IU CH - - - - - - -

V d: Dung dch cn Long no 10%

Long no 10 g Cn 90% v 100ml

V d: Dung dch Glyceroborat

Natri borat 3g Glycerin 10g

TNH CHT V VAI TR TNG CHT 1/ Natri borat: Na2B4O7.10H2O: Tinh th khng mu hoc bt kt tinh trng, khng mi, v mn d mt nc trong khng kh kh, tan trong nc. Tc dng st trng nh, thng dng sc ming, bi c hng. Vai tr: hot cht. 2/ Glycerin: Cht lng snh, t trng d = 1,32 20 oC, trong sut, khng mu, v nng v ngt, khng mi. Vai tr: Lm dung mi ha tan.

TNH CHT CH PHM: Cht lng snh, trong sut, khng mu, v ngt BO QUN: Trong chai l ming rng CNG DNG: Cha ta li tr em. Dng que qun bng hoc gc mm thm thuc bi ln li ngy 1 2 ln.

IU CH - - - -

V d: Du xoa

Menthol 0,5g Long no 0,5g Tinh du bc h 4,5ml Tinh du trm 1,5ml Metylsalicylat 0,5g Tinh du qu 1-2 git Xanh chlorophyll + du parafin v 10ml

Cc cht ph: - Cht n nh: chng oxy ha, chng thy phn - Cht lm tng tan - Cht bo qun (chng VK, nm mc) - Cht iu chnh pH - Cht ng trng ha - Cht to mu, mi - Cht lm tng nht

CC GIAI ON IU CH DUNG DCH THUC

Cc phng php ha tan c bit:

To dn cht d tan Dng cht trung gian thn nc Cht din hot Hn hp dung mi

KIM SOT CHT LNG

1/ trong, mu sc, mi v

2/ T trng

3/ pH

4/ ng u th tch

5/ nh tnh

6/ nh lng

7/ Gii hn nhim khun