Drug information resources

Done by:Fatimah Al-Shehri

Pharm.D

Tertiary Literature:It summarizes and interprets the primary literature.

Types of tertiary literature:Textbooks, compendia, handbooks, articles reviews, manuals, and online drug databases (UpToDate, Micromedex,Medscape,lexicomp etc…) It can be either

printed or electronic .

Tertiary Literature:

:AdvantagesConvenient, accessible

Inexpensive

Often available online

Presence of reference citation that can be retrieved for more specific information

Disadvantages:Lag time (delay in publication)

Lack of details about specific topics

Author’s interpretation

Secondary Literature:Used to locate primary literature and includes indexing and abstracting services.

Indexing services :provide bibliographic citations, with or without an abstract.

Abstracting services :provide summaries of primary literature articles in addition to the citation of that article.

Examples of secondary literature :->MEDLINE / PubMd

-.EMBASE (Elsevier).

-Iowa Drug Information System (IDIS).

Secondary Literature:

:AdvantagesSimple search strategies

Very current citation information

Access point for tremendous amount of primary sources

:DisadvantagesIncomplete information

Not specific to researcher needs

Some databases are expensive to access such as EMBASE

MEDLINE/PubMed:

MEDLINE/PubMed:

MEDLINE/PubMed:

Primary literature:Primary literature is one that provides original work, such as experimental or observational studies, research abstracts, case reports, analyses, or observations.

Journals, meetings symposia, and conference proceedings are considered primary information resource.

Primary literature:

:Advantages

Most current published source.

Useful when specific information is needed.

:Disadvantages

Overwhelming volume.

Necessity for article critical appraisal.

Takes long time to obtain the actual article.

Few articles are available in a free full text format.

Which literature to use?

Micromedex

Micromedex

UpToDate:

UpToDate:

Electronic Medicines Compendium. . . /www medicines org uk emc

Electronic Medicines Compendium

Electronic Medicines Compendium

Martindale

MHRA Drug Analysis Prints (DAP)

MHRA Drug Analysis Prints (DAP)

Pediatrics :Specific Information

When calculating a dose on a mg/kg basis never exceed the maximum recommended

dose (usually the adult dose). If the child is obese consider calculating using ideal

body weight

Consider if the patient is a young infant (less than 3 months old), were they premature? If so, what is their gestational age?

Consider if the route is oral, is the child able to swallow tablets

:References

The Harriet Lane Handbook

Neofax (available as a handbook at the Inpatient Pharmacy)

Micromedex (see pediatric dosing)

UpToDate (see dosing: pediatric)

Electronic Medicines Compendium .www.medicines.org.uk/emc

The Harriet Lane Handbook

ToxicologySpecific Information:

How much of the medication has been taken, and how long ago?

Consider the circumstances of the exposure, Was this an accidental, deliberate

overdose, or an administration error

Consider if the patient having any symptoms from poisoning

:References

POISONDEX

UpToDate

Electronic Medicines Compendium. www.medicines.org.uk/emc (see overdose)

POISONDEX

Click My JAMAevidence

How to use PubMed

:// . . / ? =http www youtube com watch v MM0aPxeMMRI