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Most of the drugs used to treat vitreo-retinal diseases have a narrow concentration range over which they are effective. They may be toxic at high concentrations and ineffective at low concentrations. ANSYS Fluent has been used to study the drug distribution within the eye and in turn aid in the determination of the optimal drug (or implant) location within the eye.
Buoyancy: Thermal gradients lead to flow circulation patterns in the eye, primarily in the aqueous humor.
Drug Delivery to the Eye
The following pictures show drug concentration evolution for two different implant locations. ANSYS Workbench based workflow has been developed which enables subsequent simulations with minimal manual effort.
Partitioning between tissue layers and drug clearance from outer layers: This has been implemented using User Defined Functions (UDF) in ANSYS Fluent.
After 10 days After 50 days After 100 days
Sclera Choroid Retina Vitreous
For accurate CFD modeling, following physics is included
Porous zone modeling: Hydraulic resistance of the trabecular meshwork can be manipulated to produce the desired intraocular pressure.
Outer Sclera: Episcleral venous pressure 10 torr
Vitreous Lens
Aqueous Humor
CFD model of the Eye
Cell Count ~ 1.1 M Computational Time = 20 Hrs on a single CPU
Effect of drug implant location
Fluid inflow on ciliary body behind iris
Fluid outflow behind trabecular meshwork
Iris
Half symmetry model of the eye has been used.
Outer Cornea: Atmospheric pressure 0 torr
Please contact Marc Horner ([email protected]) for details
