Dna Repair Ppt

8/18/2019 Dna Repair Ppt

1/19

KELOMPOK 4

Putri Wulandari Harahap

Ely Suzana

Roslina Horo

Yulyani KaramoyDesinthamaya

Roeslina Herawati

Claudia Roberta

Nuriyah

DNA REPAR


2/19

DNA REPAIR

SNCE !ANY !"#A#$NS ARE DE%E#ER$"S

DNA REPAR SYS#E! ARE &#A% #$ #HE S"R&&A% $'

A%% $R(ANS!S

%&N( CE%%S C$N#ANS SE&ERA% DNA REPARS SYS#E!S

CAN ') D''EREN# #YPE $' DNA A%#ERA#$NS


3/19

DNA REPAIR DNA REPAIR PROCESS :

A (R$"P $' #HE PR$CESS #HA# HAPPENED

' DNA DA!A(ED $CC"RRED

DEN#'CA#$N * REPARED DNA !$%EC"%E

DA!A(ED N (EN$!E


4/19

DNA REPAIR

DNA REPAR !ECHANS!S 'A%% N#$ + CA#E($RES

REPAR $' DA!A(E ,ASES

REPAR $' NC$RREC#%Y ,ASEPARED ,ASES D"RN(

REP%CA#$N


5/19

DNA REPAR PR$CESS

N !$S# CASES -AN RRE("%AR#Y N DNA S#R"C#"RE S DE#EC#ED

#HE A,N$R!A% DNA S RE!$&ED

N$R!A% DNA S SYN#HES.ED


6/19

/0,ASE E)CS$N REPAR SYS#E!

,ASE E)CS$N REPAR 1,ER2 N&$%&ES A CA#E($RY $' EN.Y!ES

KN$WN AS DNA3N3(%YC$SY%ASES

#HESE EN.Y!ES CAN REC$(N.E A SN(%E DA!A(ED ,ASE AND C%EA&E #HE

,$ND ,E#WEEN # AND #HE S"(AR N #HE DNARE!$&ES $NE ,ASE4 E)CSES SE&ERA% AR$"ND #4 AND REP%ACES W#H

SE&ERA% NEW ,ASES "SN( P$%!ERASE ADDN( #$ 56 ENDS #HEN %(ASE

A##ACHN( #$ 76 END

DEPENDN( $N #HE SPECES4#HS REPAR SYS#E! CAN E%!NA#E

A,N$R!A% ,ASES S"CH AS

"RAC%8 #HY!NE D!ERS


7/19

PADA ,ASA #"N((A% Y( R"SAK SE%A!A PR$SES

SE%"%ER

,ASA YAN( R"SAK D%EPASKAN $%EH DNA (%K$S%ASE

Y( !E!"#"S KA#AN (%K$SDK SEHN((A #ER,EN#"K

S#"S AP"RNK D!ANA KERAN(KA ("%A PH$SPA# #E#AP

"#"H SEDAN(KAN / ,ASA P"RN A#A" S#"S AP"RNKA#A" PR!DN H%AN(

EN.! END$N"C%EASE AP !E!"#"S KERAN(KA ("%A

PH$SPA# DAN CE%AH Y( #ER,EN#"K DPER,AK $%EH

DNA P$%!ERASE DAN DNA %(ASE0


8/19

N'$R!AS DAR "N#A Y( K$!P%E!EN#ER D("NAKAN

"N#"K !ENDK#E ,ASA YAN( HAR"S D#A!,AHKAN PADA CE%AH #ERSE,"#0

DNA P$%!ERASE / ,ERKA#AN PADA CE%AH DAN

,ER(ERAK DEN(AN ARAH 7 KE 5 4 !E%EPASKAN

N"K%E$#DA D( AK#'#AS 7 EKS$N"K%EASE 0

AK#'#AS P$%!ERASE 7 KE 5 DR DNA P$%!ERASE /

D("NAKAN "N#"K S CE%AH Y( D#N((A%KAN $%EH 7

EKS$N"K%EASE


9/19

,ASE E)CS$N REPAR SYS#E!Depending on whether a

purineor pyrimidine is removed,

thiscreates an apurinic and an

apyrimidinic site,respectively

Nick replication would bea ore accurate ter


10/19

!"N#CLEO$IDE E%CISION REPAIR S&S$EM

An important 9eneral pro:ess ;or DNA repair is Nu:leotide Ees re9ion

#hen ;ills in with Pol on 56ends4 and atta:hes 76 end with li9ase

#his types o; system :an repair many types o; DNA dama9e4 in:ludin9

#hymine dimers and :hemi:ally modi;ied bases

NER is ;ounds in all eu=aryotes and pro=aryotes

Howe>er4 its mole:ular me:hanism is better understood in pro=aryotes


11/19

N E R

SS#E! PER,AKAN K$!P%E) !E%,A#KAN ? 5@ (EN Y( DRANCAN(

"N#"K !E!PER,AK PR$D"K KER"SAKAN YAN( DND"KS "& A#A"

D!ER PR!DN0

+ SD 5@ ,ASA

!E!$#$N( KERAN(KA ("%A PH$SPA# "N#A DNA PD KE + "B"N(

DAERAH Y( R"SAK DAN !E%EPASKAN ,A(AN YAN( R"SAK #ERSE,"#

!E%EPASKAN ,ANYAK N"K%E$#DA

CE%AH Y( #ER,EN#"K SE%ANB"#NYA DS $%EH DNA P$%!ERASE

DAN KERAN(KA ("%A PH$SPA# KE!,A% DSA!,"N(KAN D(

,AN#"AN DNA %(ASE


12/19

N"C%E$#DA E)CS$N REPAR


13/19

50!S!A#CH REPAR SYS#E!

; proo; readin9 ;ails4 the methyl3dire:ted mismat:h repair system

:omes to the res:ue

#his repair system is ;ound in all spe:ies

n humans4 mutation in the system are asso:iated with parti:ular type

o; :an:er

!ethyl3 dire:ted mismat:h repair re:o9nizes mismat:hed base pairs4

e


14/19

!S!A#CH 1 !EKANS!E PER,AKAN 2 !E!PER,AK

KESA%AHAN PE!ASAN(AN ,ASA Y( #BD PD WAK#"REP%KAS DNA0

SS#E! N DAPA# D DE#EKS PADA ,ASA Y( SA%AH YAN(

DPASAN(KAN PADA "N#A DNA Y( ,AR" DSN#ESS0

!E!$#$N( ,A( Y( SA%AH DAN KE!"DAN!EN((AN#KANNYA D( REP%KAS SE#E!PA# Y(

D!EDAS $%EH P$%!ERASE DNA

K"NC "N#"K PEN((AN#AN KESA%AHAN #ERSE,"#

ADA%AH !EN(E#AH" ,ASA Y( #EPA# "N#"K (AN# ,ASAY( SA%AH


15/19

!ethyl3 dire:ted mismat:h

repair in in pro=aryotes

Parental strands are mar=ed with methyl 9roups


16/19

DNA Daa'e'rom Eidin9

Cells

Errors o; Repli:ation

or Repair

!utations Con;errin9

Sele:ti>e Ad>anta9e ;or

Clonal E


17/19

$*ANK &O#


18/19

,ASC SCENCE $' $NC$%$(Y 4 'a=ultas Kedo=teran

"ni>ersitas ndonesia4 Ba=arta +@/@


19/19

Kerusa=an untai 9anda dna -

PEN(AR"H EKS$(EN 4END$(EN

REK$!,NAS H$!$%$(

NHBE

Sistem perbai=an =erusa=an se:ara lan9sun9

DNA REPAR

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Dna Repair Ppt