DNA microarrays to determine the effect of histone deacetylase inhibition on host

response to adenovirus gene therapy vectors

http://www.kimicontrol.com/microorg/adenovirus.jpg

Mike Waters

Davidson College Biology Department

VCU BBSI

Laboratory of Dr. A. Malcolm Campbell

Laboratory of Dr. Paul Fawcett

Gene Therapy- What Is It?

• Delivery of a transgene into a host genome• Requires a vector• Retroviral, adenoviral, others

Thomas CE. 2003. Nature Reviews

Genetics 4:346-358. http://www.ngxinc.com/image/AdHTS_01.jpg

Gene Therapy- Possibilities

• Neurodegenerative Disorders– Baekelandt V., DeStrooper B., Nuttin B., Debyser Z. 2000.  Gene therapeutic strategies for

neurodegenerative diseases. Current Opinion in Molecular Therapeutics 2:540-554

• Cancer– Tseng JF & Mulligan RC. 2002. Gene therapy for pancreatic cancer. Surgical Oncology

Clinics of North America 11(3):537-569.

• HIV/AIDS– Wolkowicz R., Nolan GP. 2005.  Gene therapy progress and prospects: Novel gene therapy

approaches for AIDS. Gene Therapy 12: 467-476.

• Cardiovascular Disease– Isner, J.M. Myocardial gene therapy. 2002. Nature 415, 234-239.

• Infectious Diseases– Bunnell B & Morgan RA. 1998.  Gene therapy for infectious deceases. Clinical Microbiology

Reviews 11:42-56.

Gene Therapy- A Problem

• Viral vectors stimulate an innate immune response– Attenuates transgene expression– Cytokine storm

• Can be fatal– http://www.abc.net.au/science/news/stories/s234410.htm

http://www.jyi.org/articleimages/294/originals/img0.jpg

Biology of Innate Immunity With Respect to Adenoviral Infection

• Responsible for activation of adaptive immmunity

• Toll-like receptors recognize Pathogen Associated Molecular Patterns (PAMPs)– LPS, petidoglycan,dsRNA, CpG motifs– MyD88 dependent pathway signals type-I

interferon response

MyD88 Pathway

STAT Pathway

• STAT= signal transduction and activator of transcription

• Recognizes interferons to produce antiviral state– Upregulate genes

involved in immune response

http://www.nature.com/nri/journal/v5/n9/pdf/nri1684.pdf

Take Home Biology

• TLR recognizes presence of PAMPs

• Stimulates MyD88 dependent pathway

• MyD88 dependent pathway produces an interferon and inflammatory response

• Interferons activate STAT pathway

• STAT pathway up regulates ISRE controlled genes

Histone Deacetylase Inhibitors

Acetylation = important modulator of cellular response/ signal transduction

• HAT/HDAC• HDAC inhibition has recently been shown to

modulate interferon response

http://www.phy.mtu.edu/images/menu/HistoneAcetylation.jpg

Big Question

• Can treatment with an HDAC inhibitor transiently suppress the innate immune system to obtain stable gene expression?

• Compare the host response to adenoviral infection in the presence and absence of an HDAC inhibitor

DNA Microarrays

• GOAL - A quantifiable image of relative cDNA amounts between two conditions

• + TSA and –TSA– TSA=HDAC inhibitor

Technique- DNA Microarrays

i. Prep Hepatocytes

ii. Treat selected conditions (add TSA)

iii. Infect with Adenovirus

iv. Harvest RNA using lysis buffer according to experimental time course

v. Prep and purify RNA

vi. Amplify RNA

vii. Clean aRNA

viii. Dye Couple

ix. Hybridize RNA to post-processed microarray slide

x. Clean hybridized array

xi. Scan

xii. Grid

xiii. RAM horn database

DNA Microarrays

For each timepoint, cDNAs representing mockinfected cells (labeled w/ Cy3) and cDNAs

representing infected or treated cells (labeledw/ Cy5) are hybridized to the same array

Mock InfectionControl

Listeria Infectedcells

Adenovirus transduced hepatocytes

Adenovirus transduced hepatocytes + TSA

Initial Conditions

• MOI

• Cell Type– Hepatocyte– RAW (macrophage like)– BMDM (bone marrow derived macrophages)

Results

• I was successful in obtaining a “gridable” microarray

•Next step= make sense of data

Results analysis- Preface

• Work in progress

• The host responose to adenovirus, helper-dependent adenovirus and adeno-associated virus in mouse liver

McCaffrey AP., Fawcett., Nakai H., McCaffrey L., Ehrhardt A., Pham T., Pandy K., Xu H., Feuss S., Storm T., Kay MA. 2008. The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Molecular Therapy 16(5):931-941

Results

• Immune Response Genes • Signal Transduction • Transcription• Cell Cycle• Apoptosis• Chromatin Stucture• Cell Structure• Cell metabolism

Immune Response Genes

• Upregulation upon infection (Fawcett)

TNF Interacting Protein -4.272

Interferon Tau -3.822

Interferon Alpha -2.05

CBP -4.891

Interleukin enhanced binding domain -2.031

Signal Transduction

• Upregulated upon adenoviral infection

TNF receptor superfamily 7 -2.165

Leptin receptor -3.165

Lemur tyrosine kinase 2 -2.05

Adenosine A1 receptor -2.05

Lymphocyte protein tyrosine kinase -1.757

Future DirectionsUID ANNOTATION0 ANNOTATION1 ANNOTATION2 6 -TSA vs. 6 +TSA adenovirusMSQ004000 scl31989.25.1_124 transforming, acidic coiled-coil containing protein 2 Tacc2::transforming, acidic coiled-coil containing protein 2 -1.202MSQ036237 IGHV1S105|L33944|Ig_heavy_variable_1S105_10Mus musculus clone CPS2.9 germline Ig variable region heavy chain precursor pseudogene, partial sequence. -1.136MSQ035677 scl000885.1_482 Mus musculus inhibitor of growth family, member 5 (Ing5), mRNA.Ing5::inhibitor of growth family, member 5 1.241MSQ024921 scl066477.2_23 upregulated during skeletal muscle growth 5 Usmg5::upregulated during skeletal muscle growth 5 -1.279MSQ004901 scl44736.3.1_23 RIKEN cDNA 2610524G07 gene 2610524G07Rik::RIKEN cDNA 2610524G07 gene 1.545MSQ019071 scl25451.20.1_292 inversin Invs::inversin -1.189MSQ014819 scl19446.4_4 lipocalin 2 Lcn2::lipocalin 2 -1.087MSQ007899 scl53171.3_143 RIKEN cDNA A330032B11 gene A330032B11Rik::RIKEN cDNA A330032B11 gene 1.452MSQ028992 scl00229285.2_94 spastic paraplegia 20, spartin (Troyer syndrome) homolog (human) Spg20::spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)-2.728MSQ030471 scl0018950.1_0 purine-nucleoside phosphorylase Pnp::purine-nucleoside phosphorylase 1.152MSQ034538 scl0002025.1_104 Mucin 1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).Muc1::mucin 1, transmembrane -2.298MSQ007204 scl44814.23_93 amine oxidase, flavin containing 1 Aof1::amine oxidase, flavin containing 1 1.154MSQ023976 scl019349.2_45 RAB7, member RAS oncogene family Rab7::RAB7, member RAS oncogene family -1.404MSQ034561 scl000932.1_92 Mus musculus bisphosphate 3'-nucleotidase 1 (Bpnt1), mRNA.Bpnt1::bisphosphate 3'-nucleotidase 1 1.012MSQ011578 scl16114.13_1 quiescin Q6 Qscn6::quiescin Q6 -1.568MSQ035594 scl0002427.1_4 Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700006H03 product:hypothetical protein, full insert sequence.1700006H03Rik::RIKEN cDNA 1700006H03 gene -1.05MSQ018774 scl45708.4.1_80 RIKEN cDNA 2610528A11 gene 2610528A11Rik::RIKEN cDNA 2610528A11 gene -1.391MSQ034670 scl0001715.1_3 Mus musculus HLA-B-associated transcript 1A (Bat1a), mRNA.Bat1a::HLA-B-associated transcript 1A 1.036MSQ020044 scl022282.1_12 upstream transcription factor 2 Usf2::upstream transcription factor 2 -2.331MSQ018869 scl43347.15_53 O-acyltransferase (membrane bound) domain containing 2Oact2::O-acyltransferase (membrane bound) domain containing 2 -1.527MSQ001432 scl00319622.1_241 Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130081G24 product:hypothetical protein, full insert sequence.C130081G24::hypothetical protein C130081G24 1.804MSQ005532 scl16374.9.1_0 RIKEN cDNA 1010001D01 gene 1010001D01Rik::RIKEN cDNA 1010001D01 gene 1.082MSQ020269 scl068837.8_1 RIKEN cDNA 1110054H05 gene 1110054H05Rik::RIKEN cDNA 1110054H05 gene 1.233MSQ002046 scl11622.2.1_26 RIKEN cDNA 9830169D19 gene Usp33::ubiquitin specific protease 33 -4.787MSQ004935 scl42820.4.1_101 T-cell leukemia/lymphoma 1B, 4 Tcl1b4::T-cell leukemia/lymphoma 1B, 4 1.164MSQ015169 scl25474.9_230 RNA (guanine-9-) methyltransferase domain containing 3Rg9mtd3::RNA (guanine-9-) methyltransferase domain containing 3-1.014MSQ004169 scl51807.2.1_60 melanocortin 5 receptor Mc5r::melanocortin 5 receptor 1.084MSQ024014 scl069790.3_16 thyroid hormone receptor associated protein 6 Thrap6::thyroid hormone receptor associated protein 6 -1.379MSQ020417 scl016170.1_67 interleukin 16 Il16::interleukin 16 2.959MSQ025861 scl072477.16_0 RIKEN cDNA 2610301K12 gene 2610301K12Rik::RIKEN cDNA 2610301K12 gene 1.006MSQ007539 scl53371.28_117 damage specific DNA binding protein 1 Ddb1::damage specific DNA binding protein 1 -1.033MSQ005443 scl26936.17.1_17 leucine-rich repeat-containing G protein-coupled receptor 8Lgr8::leucine-rich repeat-containing G protein-coupled receptor 8 1.347MSQ009868 scl41293.8_78 carbohydrate kinase-like Carkl::carbohydrate kinase-like -1.674MSQ013109 scl43946.12_42 ring finger protein 44 Rnf44::ring finger protein 44 1.45MSQ027197 scl0020015.1_56 ribophorin 2, related sequence 1 Rpn2-rs1::ribophorin 2, related sequence 1 -2.352MSQ023515 scl068193.4_35 ribosomal protein L24 Rpl24::ribosomal protein L24 -1.13MSQ013530 scl39342.3.1_207 Usher syndrome 1G homolog (human) Ush1g::Usher syndrome 1G homolog (human) 1.493MSQ023612 scl059033.25_59 solute carrier family 4 (anion exchanger), member 8 Slc4a8::solute carrier family 4 (anion exchanger), member 8 1.02MSQ002091 scl37323.16_486 CWF19-like 2, cell cycle control (S. pombe) Cwf19l2::CWF19-like 2, cell cycle control (S. pombe) 1.59MSQ019510 scl013629.14_1 eukaryotic translation elongation factor 2 Eef2::eukaryotic translation elongation factor 2 -1.161MSQ032886 scl000239.1_11 Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase, 4 (Psmc4), mRNA.Psmc4::proteasome (prosome, macropain) 26S subunit, ATPase, 4-1.034MSQ003587 scl32211.7.1_6 eukaryotic translation initiation factor 3, subunit 5 (epsilon) Eif3s5::eukaryotic translation initiation factor 3, subunit 5 (epsilon) -1.056MSQ017500 scl41498.1_708 expressed sequence AI647711 AI647711::expressed sequence AI647711 -1.372MSQ001127 scl23773.12.1_52 lymphocyte protein tyrosine kinase Lck::lymphocyte protein tyrosine kinase -1.757MSQ025686 scl022143.2_192 tubulin, alpha 2 Tuba2::tubulin, alpha 2 -1.044MSQ014182 scl21752.24.8_3 ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1::ATPase, Na+/K+ transporting, alpha 1 polypeptide -1.342MSQ025873 scl0208715.1_140 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1Hmgcs1::3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 -1.18MSQ013781 scl5161.1.1_317 olfactory receptor 798 Olfr798::olfactory receptor 798 -2.181MSQ006780 scl23175.3_26 transmembrane 4 superfamily member 4 Tm4sf4::transmembrane 4 superfamily member 4 -1.263MSQ019233 scl068028.3_20 RIKEN cDNA 3110001N18 gene 3110001N18Rik::RIKEN cDNA 3110001N18 gene -1.308MSQ012475 scl27459.1.1_117 RIKEN cDNA 0710007G10 gene 0710007G10Rik::RIKEN cDNA 0710007G10 gene 1.103MSQ016668 scl24779.12.1_2 capping protein (actin filament) muscle Z-line, beta Capzb::capping protein (actin filament) muscle Z-line, beta -1.858MSQ006581 scl36036.4.1_1 RIKEN cDNA 1700027I24 gene 1700027I24Rik::RIKEN cDNA 1700027I24 gene -2.713MSQ021592 scl068612.6_90 ubiquitin-conjugating enzyme E2C Ube2c::ubiquitin-conjugating enzyme E2C 1.771MSQ006354 scl37824.3.1_49 RIKEN cDNA A330049N07 gene A330049N07Rik::RIKEN cDNA A330049N07 gene 1.268MSQ015197 scl53605.17.1_53 motile sperm domain containing 2 Mospd2::motile sperm domain containing 2 -1.162MSQ013524 scl23244.2.331_43 RIKEN cDNA 6030410K14 gene 6030410K14Rik::RIKEN cDNA 6030410K14 gene 1.28MSQ003977 scl45489.6.1_24 RIKEN cDNA 2510005D08 gene 2510005D08Rik::RIKEN cDNA 2510005D08 gene 1.068MSQ004576 scl6849.1.1_0 RIKEN cDNA 1700094I16 gene 1700094I16Rik::RIKEN cDNA 1700094I16 gene 1.198MSQ020648 scl0212073.1_166 RIKEN cDNA 4831426I19 gene 4831426I19Rik::RIKEN cDNA 4831426I19 gene -1.002MSQ017388 scl26088.14.1_16 aldehyde dehydrogenase 2, mitochondrial Aldh2::aldehyde dehydrogenase 2, mitochondrial -1.645MSQ014734 scl52198.1_179 RIKEN cDNA D430002O22 gene C230079D11Rik::RIKEN cDNA C230079D11 gene -1.196MSQ024374 scl070356.1_235 suppression of tumorigenicity 13 St13::suppression of tumorigenicity 13 1.087MSQ028937 scl00234203.2_34 zinc finger protein 353 Zfp353::zinc finger protein 353 -1.281MSQ002289 scl18477.12.1_53 sperm associated antigen 4-like Spag4l::sperm associated antigen 4-like -1.165MSQ004864 scl50087.9.265_72 glyoxalase 1 Glo1::glyoxalase 1 -1.787MSQ007076 scl17789.7.1_75 cytochrome P450, family 27, subfamily a, polypeptide 1 Cyp27a1::cytochrome P450, family 27, subfamily a, polypeptide 1 -1.025MSQ028527 scl00320473.1_51 RIKEN cDNA A230048G03 gene A230048G03Rik::RIKEN cDNA A230048G03 gene -3.272MSQ026130 scl0076890.1_96 RIKEN cDNA 0610016J10 gene 0610016J10Rik::RIKEN cDNA 0610016J10 gene -1.551MSQ014572 scl19407.9_43 F-box and WD-40 domain protein 2 Fbxw2::F-box and WD-40 domain protein 2 1.016MSQ028438 scl0020054.1_111 ribosomal protein S15 Rps15::ribosomal protein S15 -1.153MSQ023778 scl020674.7_60 SRY-box containing gene 2 Sox2::SRY-box containing gene 2 1.082MSQ023399 scl0240697.10_304 RIKEN cDNA 6030422M02 gene 6030422M02Rik::RIKEN cDNA 6030422M02 gene 1.134MSQ016459 scl36089.6_17 RIKEN cDNA 2310075A12 gene 2310075A12Rik::RIKEN cDNA 2310075A12 gene 1.118MSQ018510 scl50293.3.1_15 RIKEN cDNA 4930474M22 gene 4930474M22Rik::RIKEN cDNA 4930474M22 gene 1.448MSQ035350 scl0000113.1_1 Mus musculus polymerase (RNA) II (DNA directed) polypeptide B (Polr2b), mRNA.Polr2b::polymerase (RNA) II (DNA directed) polypeptide B 1.08MSQ019601 scl022146.5_240 tubulin, alpha 6 Tuba6::tubulin, alpha 6 -1.242MSQ024451 scl030951.1_46 chromobox homolog 8 (Drosophila Pc class) Cbx8::chromobox homolog 8 (Drosophila Pc class) 1.182MSQ015336 scl36809.14.1_41 caseinolytic protease X (E.coli) Clpx::caseinolytic protease X (E.coli) -1.026MSQ028113 scl0070686.2_11 dual specificity phosphatase 16 Dusp16::dual specificity phosphatase 16 -1.169MSQ007418 scl24528.5_32 copine III Cpne3::copine III 1.304MSQ024602 scl076936.1_75 heterogeneous nuclear ribonucleoprotein M Hnrpm::heterogeneous nuclear ribonucleoprotein M -1.106MSQ016213 scl46732.12_85 longevity assurance homolog 5 (S. cerevisiae) Lass5::longevity assurance homolog 5 (S. cerevisiae) 2.857MSQ014050 scl47686.9.1_164 cytochrome P450, family 2, subfamily d, polypeptide 9 Cyp2d9::cytochrome P450, family 2, subfamily d, polypeptide 9 -1.173MSQ021888 scl056529.1_95 signal peptidase complex Sec11l1::Sec11-like 1 (S. cerevisiae) -1.128MSQ019129 scl32252.1.1_8 olfactory receptor 659 Olfr659::olfactory receptor 659 1.149MSQ025594 scl019821.1_18 ring finger protein 2 Rnf2::ring finger protein 2 1.021MSQ020135 scl019941.2_3 ribosomal protein L26 Rpl26::ribosomal protein L26 -1.302MSQ031006 scl0076846.1_142 ribosomal protein S9 Rps9::ribosomal protein S9 -1.041MSQ006694 scl45510.5.1_78 granzyme C Gzmc::granzyme C -1.05MSQ006441 scl54930.9.1_1 hypoxanthine guanine phosphoribosyl transferase 1Hprt1::hypoxanthine guanine phosphoribosyl transferase 1 -1.026MSQ003865 scl21320.10.1_37 nudix (nucleoside diphosphate linked moiety X)-type motif 5Nudt5::nudix (nucleoside diphosphate linked moiety X)-type motif 53.343MSQ020363 scl016668.7_96 keratin complex 1, acidic, gene 18 Krt1-18::keratin complex 1, acidic, gene 18 -1.776MSQ018040 scl32836.5_532 zinc finger protein 30 Zfp30::zinc finger protein 30 -1.003MSQ015813 scl46165.1.1_171 RIKEN cDNA 9530047P18 gene 9530047P18Rik::RIKEN cDNA 9530047P18 gene 1.265MSQ025168 scl066054.1_17 CNDP dipeptidase 2 (metallopeptidase M20 family)Cndp2::CNDP dipeptidase 2 (metallopeptidase M20 family) -1.457MSQ020962 scl056445.1_3 DnaJ (Hsp40) homolog, subfamily A, member 2 Dnaja2::DnaJ (Hsp40) homolog, subfamily A, member 2 -1.568MSQ001667 scl29243.5.1_44 RIKEN cDNA 3110069A13 gene 3110069A13Rik::RIKEN cDNA 3110069A13 gene 1.293MSQ025518 scl0404330.1_63 olfactory receptor 1198 Olfr1198::olfactory receptor 1198 1.241MSQ018019 scl22790.20.1_134 RIKEN cDNA A930010I20 gene A930010I20Rik::RIKEN cDNA A930010I20 gene 2.009MSQ018882 scl31069.1.112_64 olfactory receptor 305 Olfr305::olfactory receptor 305 1.119MSQ021364 scl077868.1_22 RIKEN cDNA E130112H22 gene E130112H22Rik::RIKEN cDNA E130112H22 gene -6.31MSQ015497 scl53255.10.1_6 RIKEN cDNA D330024H06 gene Ankrd15::ankyrin repeat domain 15 1.509MSQ001050 scl20917.35_21 formin-like 2 Fmnl2::formin-like 2 -1.854MSQ029619 scl0026438.1_171 pregnancy specific glycoprotein 18 Psg18::pregnancy specific glycoprotein 18 1.005MSQ026492 scl0022185.2_38 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2U2af2::U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 21.228MSQ021753 scl015018.6_2 histocompatibility 2, Q region locus 7 H2-Q7::histocompatibility 2, Q region locus 7 -1.159MSQ032857 scl000890.1_7 Mus musculus apolipoprotein A-II (Apoa2), mRNA.Apoa2::apolipoprotein A-II 2.95MSQ009985 scl14726.1.1_285 RIKEN cDNA 1700113H21 gene 1700113H21Rik::RIKEN cDNA 1700113H21 gene 1.295MSQ002778 scl34121.21.1_1 RIKEN cDNA B130050I23 gene B130050I23Rik::RIKEN cDNA B130050I23 gene -2.41MSQ029979 scl00269630.1_95 cDNA sequence BC050254 BC050254::cDNA sequence BC050254 -4.509MSQ004852 scl24124.1.1_107 interferon tau-1 Ifne1::interferon epsilon 1 -2.967MSQ030346 scl0054683.2_242 peroxiredoxin 5 Prdx5::peroxiredoxin 5 -1.663MSQ007467 scl22656.1_111 translocation associated membrane protein 1-like 1Tram1l1::translocation associated membrane protein 1-like 1 1.337MSQ017898 scl22674.5.18_162 calponin 3, acidic Cnn3::calponin 3, acidic -2.796MSQ023744 scl069721.4_6 NFKB inhibitor interacting Ras-like protein 1 Nkiras1::NFKB inhibitor interacting Ras-like protein 1 2.928MSQ026970 scl0014481.1_2 granule cell antiserum positive 27 Gcap27::granule cell antiserum positive 27 1.034MSQ010338 scl54862.7.1_262 RIKEN cDNA 9230118O15 gene Fate1::fetal and adult testis expressed 1 1.636MSQ009266 scl36947.19_123 nuclear protein in the AT region Npat::nuclear protein in the AT region 1.69MSQ014175 scl49197.1.55_65 myosin, light polypeptide kinase Mylk::myosin, light polypeptide kinase 1.483MSQ021513 scl069549.2_9 RIKEN cDNA 2310009B15 gene 2310009B15Rik::RIKEN cDNA 2310009B15 gene -5.019MSQ011266 scl31324.2.1_106 MAS-related GPR, member B2 Mrgprb2::MAS-related GPR, member B2 1.379MSQ025883 scl013517.10_7 dentin sialophosphoprotein Dspp::dentin sialophosphoprotein -1.22MSQ013782 scl20807.21.1_18 dynein, cytoplasmic, intermediate chain 2 Dncic2::dynein, cytoplasmic, intermediate chain 2 -1.222MSQ014536 scl31682.2_22 biogenesis of lysosome-related organelles complex-1, subunit 3 Bloc1s3::biogenesis of lysosome-related organelles complex-1, subunit 3-2.614MSQ008754 scl20613.1.1_316 RIKEN cDNA 2810427C15 gene 2810427C15Rik::RIKEN cDNA 2810427C15 gene 1.468MSQ016998 scl33962.6.1_87 phosphatidic acid phosphatase type 2 domain containing 1Ppapdc1::phosphatidic acid phosphatase type 2 domain containing 1-1.509MSQ020523 scl097501.1_18 expressed sequence W91709 Elavl1::ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)1.84MSQ025796 scl075654.1_64 RIKEN cDNA 1700003O08 gene 1700003O08Rik::RIKEN cDNA 1700003O08 gene -1.494MSQ005289 scl36943.2.1_2 RIKEN cDNA 1700104A03 gene 1700104A03Rik::RIKEN cDNA 1700104A03 gene 1.737MSQ028180 scl0070747.2_23 RIKEN cDNA 6330415F13 gene Tspan2::tetraspan 2 -1.58MSQ010805 scl46254.30.2_18 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1Parp4::poly (ADP-ribose) polymerase family, member 4 -4.109MSQ024184 scl014468.10_101 guanylate nucleotide binding protein 1 Gbp1::guanylate nucleotide binding protein 1 1.682MSQ025237 scl0105418.7_213 RIKEN cDNA E330034G19 gene E330034G19Rik::RIKEN cDNA E330034G19 gene 2.04MSQ019775 scl012385.18_225 catenin alpha 1 Catna1::catenin alpha 1 -1.058MSQ025040 scl068069.1_6 RIKEN cDNA 3010022N24 gene 3010022N24Rik::RIKEN cDNA 3010022N24 gene 1.321MSQ026540 scl0073447.1_127 WD repeat domain 13 Wdr13::WD repeat domain 13 1.109MSQ020495 scl014779.1_116 glutathione peroxidase 4 Gpx4::glutathione peroxidase 4 -1.479MSQ018616 scl37699.11.9_0 fizzy/cell division cycle 20 related 1 (Drosophila) Fzr1::fizzy/cell division cycle 20 related 1 (Drosophila) -2.531MSQ033340 scl0003097.1_18 Mus musculus serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) (Spinlw1), mRNA.Spinlw1::serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)1.225MSQ029670 scl00104252.2_200 CDC42 effector protein (Rho GTPase binding) 2 Cdc42ep2::CDC42 effector protein (Rho GTPase binding) 2 1.029MSQ005929 scl50999.7.56_77 T-complex expressed gene 1 Tce1::T-complex expressed gene 1 -1.465MSQ001930 scl42015.3_219 cell division cycle associated 4 Cdca4::cell division cycle associated 4 1.659MSQ024323 scl018521.14_30 poly(rC) binding protein 2 Pcbp2::poly(rC) binding protein 2 -1.56MSQ019105 scl23131.18_205 potassium voltage-gated channel, shaker-related subfamily, beta member 1 Kcnab1::potassium voltage-gated channel, shaker-related subfamily, beta member 1-3.109MSQ024393 scl020918.4_11 suppressor of initiator codon mutations, related sequence 1 (S. cerevisiae) Sui1-rs1::suppressor of initiator codon mutations, related sequence 1 (S. cerevisiae)-1.089MSQ007557 scl29869.6.1_197 regenerating islet-derived 3 alpha Reg3a::regenerating islet-derived 3 alpha 1.04MSQ021067 scl012912.7_30 cAMP responsive element binding protein 1 Creb1::cAMP responsive element binding protein 1 -4.891MSQ017471 scl53214.6.1_26 mannose binding lectin, serum (C) Mbl2::mannose binding lectin, serum (C) -1.114MSQ017351 scl25097.18.1_152 Tal1 interrupting locus Sil::Tal1 interrupting locus -2.988MSQ032788 scl0002778.1_20 Mus musculus aspartate-beta-hydroxylase (Asph), mRNA.Asph::aspartate-beta-hydroxylase 1.815MSQ006775 scl8846.1.1_13 olfactory receptor 702 Olfr702::olfactory receptor 702 1.413MSQ001144 scl52210.15_411 desmoglein 2 Dsg2::desmoglein 2 -1.132MSQ030654 scl00257913.1_18 olfactory receptor 141 Olfr141::olfactory receptor 141 1.135MSQ021859 scl075617.3_32 ribosomal protein S25 Rps25::ribosomal protein S25 -1.279MSQ009179 scl47912.4.1_215 mal, T-cell differentiation protein 2 Mal2::mal, T-cell differentiation protein 2 -1.276MSQ028486 scl0019943.2_84 ribosomal protein L28 Rpl28::ribosomal protein L28 -1.195MSQ034403 scl0003225.1_73 Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), mRNA.Tank::TRAF family member-associated Nf-kappa B activator 1.272MSQ030561 scl00244867.2_39 Rho GTPase activating protein 20 Arhgap20::Rho GTPase activating protein 20 -2.635MSQ018348 scl47001.5_47 thioredoxin 2 Txn2::thioredoxin 2 -1.06MSQ034791 scl0002437.1_2 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720463G22 product:inferred: IDN3 {Homo sapiens}, full insert sequence.Nipbl::Nipped-B homolog (Drosophila) -1.787MSQ007271 scl22806.1.3_180 RIKEN cDNA 4632404M16 gene 4632404M16Rik::RIKEN cDNA 4632404M16 gene -1.857MSQ027640 scl0019157.1_43 pleckstrin homology, Sec7 and coiled-coil domains 1 Pscd1::pleckstrin homology, Sec7 and coiled-coil domains 1 -2.093MSQ001503 scl0020788.1_174 Mus musculus sterol regulatory element binding protein 2 (Srebp2) mRNA, partial cds.Srebf2::sterol regulatory element binding factor 2 1.219MSQ028808 scl00320202.1_47 endometrial bleeding associated factor Lefty2::Left-right determination factor 2 -1.128MSQ003928 scl46952.14.1_6 neuronal pentraxin receptor Nptxr::neuronal pentraxin receptor -1.117MSQ003533 scl54503.31.1_53 phosphorylase kinase alpha 2 Phka2::phosphorylase kinase alpha 2 -1.618MSQ028576 scl00243085.1_25 hypothetical protein C730031G17 C730031G17::hypothetical protein C730031G17 -1.161MSQ006008 scl24151.12.434_2 adipose differentiation related protein Adfp::adipose differentiation related protein -1.035MSQ029548 scl0069721.2_295 NFKB inhibitor interacting Ras-like protein 1 Nkiras1::NFKB inhibitor interacting Ras-like protein 1 1.289MSQ023274 scl052120.1_108 DNA segment, Chr 8, ERATO Doi 354, expressed D8Ertd354e::DNA segment, Chr 8, ERATO Doi 354, expressed -1.153MSQ004173 scl19180.25_455 sodium channel, voltage-gated, type VI, alpha polypeptide Scn7a::sodium channel, voltage-gated, type VII, alpha -1.635MSQ036450 IGHV8S10|U23025|Ig_heavy_variable_8S10_26Mus musculus C57BL/6 immunoglobulin heavy chain V region mRNA, clone CB17H-9, partial cds. 1.019MSQ030585 scl0011516.2_115 adenylate cyclase activating polypeptide 1 Adcyap1::adenylate cyclase activating polypeptide 1 1.078MSQ025397 scl076913.1_222 RIKEN cDNA 1110053K06 gene Capza2::capping protein (actin filament) muscle Z-line, alpha 2 -2.867MSQ008368 scl16450.3.1_125 RIKEN cDNA 4930533P14 gene 4930533P14Rik::RIKEN cDNA 4930533P14 gene -3.857MSQ019641 scl071751.8_56 RIKEN cDNA 1300002E11 gene Map3k13::mitogen-activated protein kinase kinase kinase 13 1.404MSQ021274 scl014828.8_22 heat shock 70kD protein 5 (glucose-regulated protein)Hspa5::heat shock 70kD protein 5 (glucose-regulated protein) -1.29MSQ004684 scl37097.1.1_62 olfactory receptor 899 Olfr899::olfactory receptor 899 1.178MSQ004365 scl46160.15.1_21 clusterin Clu::clusterin -1.317MSQ036269 IGKV4-78|AJ231212|Ig_kappa_variable_4-78_15Mus musculus IgVk ad4 gene. 2.499MSQ023941 scl0109255.1_109 RIKEN cDNA C330012K04 gene C330012K04Rik::RIKEN cDNA C330012K04 gene -1.372MSQ004571 scl4282.1.1_58 olfactory receptor 1232 Olfr1232::olfactory receptor 1232 1.354MSQ017639 scl53685.5.1_179 patched domain containing 1 Ptchd1::patched domain containing 1 -2.05MSQ000824 scl43390.14.1_51 hypothetical protein 4931412M21 4931412M21::hypothetical protein 4931412M21 -1.5MSQ020237 scl013003.1_89 chondroitin sulfate proteoglycan 2 Cspg2::chondroitin sulfate proteoglycan 2 -2.205MSQ009340 scl31835.5.1_93 osteoclast associated receptor Oscar::osteoclast associated receptor 1.941MSQ023804 scl057267.10_22 amyloid beta (A4) precursor protein-binding, family A, member 3 Apba3::amyloid beta (A4) precursor protein-binding, family A, member 3-2.228MSQ016083 scl33610.6.1_104 uncoupling protein 1, mitochondrial Ucp1::uncoupling protein 1 (mitochondrial, proton carrier) -1.88MSQ016732 scl26002.22.1_75 RIKEN cDNA A930033C01 gene A930033C01Rik::RIKEN cDNA A930033C01 gene 1.517MSQ001980 scl28406.5_14 tumor necrosis factor receptor superfamily, member 7 Tnfrsf7::tumor necrosis factor receptor superfamily, member 7 -2.165MSQ019107 scl40799.17_134 mitogen activated protein kinase kinase kinase 3 Map3k3::mitogen activated protein kinase kinase kinase 3 1.479MSQ025452 scl013627.1_210 eukaryotic translation elongation factor 1 alpha 1 Eef1a1::eukaryotic translation elongation factor 1 alpha 1 -1.361MSQ015951 scl18985.4_291 solute carrier family 35, member C1 Slc35c1::solute carrier family 35, member C1 1.469MSQ005179 scl4917.1.1_188 olfactory receptor 1120 Olfr1120::olfactory receptor 1120 1.066MSQ033281 scl000397.1_19 Mus musculus RIKEN cDNA 2400006A19 gene (2400006A19Rik), mRNA.2400006A19Rik::RIKEN cDNA 2400006A19 gene -1.018MSQ001485 scl00224111.2_302 Mus musculus hypothetical protein A630090P18 (A630090P18), mRNA. 1.398MSQ003329 scl25272.22.1_44 RIKEN cDNA 2310009E04 gene 2310009E04Rik::RIKEN cDNA 2310009E04 gene 1.596MSQ024420 scl030938.1_113 FYVE, RhoGEF and PH domain containing 3 Fgd3::FYVE, RhoGEF and PH domain containing 3 3.95MSQ010968 scl35336.10.1_10 hypothetical protein E330023O18 Fbxw19::F-box and WD-40 domain protein 19 1.241MSQ024607 scl067150.2_3 ring finger protein 141 Rnf141::ring finger protein 141 -1.58MSQ015725 scl29080.9.2_12 Eph receptor A1 Epha1::Eph receptor A1 -4.924MSQ017718 scl52657.1.1_144 RIKEN cDNA 9030607L02 gene 9030607L02Rik::RIKEN cDNA 9030607L02 gene -2.05MSQ029817 scl00104570.2_297 expressed sequence AW011752 AW011752::expressed sequence AW011752 -2.181MSQ025784 scl020655.4_35 superoxide dismutase 1, soluble Sod1::superoxide dismutase 1, soluble -1.106MSQ013822 scl27087.3.5_17 alpha-2-glycoprotein 1, zinc Azgp1::alpha-2-glycoprotein 1, zinc -1.242MSQ014875 scl50064.18_425 widely-interspaced zinc finger motifs Wiz::widely-interspaced zinc finger motifs 1.019MSQ032107 scl0003853.1_11 Mus musculus leukotriene A4 hydrolase (Lta4h), mRNA.Lta4h::leukotriene A4 hydrolase -1.005MSQ003695 scl17803.10.1_30 actin related protein 2/3 complex, subunit 2 Arpc2::actin related protein 2/3 complex, subunit 2 -1.331MSQ009893 scl23220.4.1_166 hypothetical protein A630062H14 A630062H14::hypothetical protein A630062H14 1.11MSQ003508 scl52521.4_54 RIKEN cDNA 4931408D14 gene 4931408D14Rik::RIKEN cDNA 4931408D14 gene -2.031MSQ030728 scl0077593.2_32 RIKEN cDNA 4930550B20 gene Usp45::ubiquitin specific protease 45 -2.988MSQ007190 scl31468.1_378 regulator of G-protein signalling 9 binding protein Rgs9bp::regulator of G-protein signalling 9 binding protein 1.011MSQ005379 scl19031.1_132 olfactory receptor 1199 Olfr1199::olfactory receptor 1199 1.312MSQ006623 scl33186.17_230 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2Galnt2::UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2-1.193MSQ004600 scl34303.2_339 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5Chst5::carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 1.274MSQ008314 scl33513.12_427 fatso Fto::fatso 1.037MSQ015998 scl54532.1_61 ubiquilin 2 Ubqln2::ubiquilin 2 -1.041MSQ026258 scl075657.5_307 spermatogenesis associated glutamate (E)-rich protein 4aSpeer4a::spermatogenesis associated glutamate (E)-rich protein 4a1.032MSQ021034 scl027207.2_8 ribosomal protein S11 Rps11::ribosomal protein S11 -1.366MSQ019122 scl40211.15.187_58 TNFAIP3 interacting protein 1 Tnip1::TNFAIP3 interacting protein 1 -4.272MSQ002533 scl36313.6.1_58 RIKEN cDNA C730027P07 gene C730027P07Rik::RIKEN cDNA C730027P07 gene -2.339MSQ019654 scl016898.7_20 ribosomal protein S2 Rps2::ribosomal protein S2 -1.102MSQ015192 scl19416.1.1466_20 RIKEN cDNA B930068K11 gene B930068K11Rik::RIKEN cDNA B930068K11 gene -8.589MSQ034294 scl0003045.1_120 Mus musculus glutamic acid decarboxylase 1 (Gad1), mRNA.Gad1::glutamic acid decarboxylase 1 -2.272MSQ006251 scl32299.7.1_25 START domain containing 10 Stard10::START domain containing 10 -1.828MSQ008374 scl42288.2.1_61 RIKEN cDNA 1700052I22 gene 1700052I22Rik::RIKEN cDNA 1700052I22 gene 1.194MSQ025650 scl066481.4_0 ribosomal protein S21 Rps21::ribosomal protein S21 -1.177MSQ026624 scl00114675.1_35 RIKEN cDNA 4932431P20 gene 4932431P20Rik::RIKEN cDNA 4932431P20 gene -4.465MSQ028836 scl0068299.1_136 RIKEN cDNA 3100002B05 gene 3100002B05Rik::RIKEN cDNA 3100002B05 gene -1.291MSQ025406 scl0270112.11_225 hypothetical protein C530029I03 C530029I03::hypothetical protein C530029I03 2.021MSQ019433 scl020195.2_6 S100 calcium binding protein A11 (calizzarin) S100a11::S100 calcium binding protein A11 (calizzarin) -1.233MSQ035986 mtDNA_CytB 1.062MSQ018026 scl24578.6.1_109 cytochrome P450, family 7, subfamily a, polypeptide 1 Cyp7a1::cytochrome P450, family 7, subfamily a, polypeptide 1 1.702MSQ021379 scl016699.1_183 keratin associated protein 13 Krtap13::keratin associated protein 13 1.23MSQ008789 scl18236.13.1_24 RIKEN cDNA 3830402K23 gene 3830402K23Rik::RIKEN cDNA 3830402K23 gene -2.713MSQ005022 scl29496.8_95 sodium channel, nonvoltage-gated, type I, alpha polypeptide Scnn1a::sodium channel, nonvoltage-gated, type I, alpha 1.881MSQ007174 scl16848.5_127 thioredoxin domain containing 9 Txndc9::thioredoxin domain containing 9 1.826MSQ008720 scl41798.24_462 vacuolar protein sorting 54 (yeast) Vps54::vacuolar protein sorting 54 (yeast) -1.157MSQ004384 scl28059.1.1_188 RIKEN cDNA A930037G07 gene A930037G07Rik::RIKEN cDNA A930037G07 gene -1.143MSQ018952 scl15004.1.1_160 RIKEN cDNA A930009H06 gene Fhod3::formin homology 2 domain containing 3 -1.722MSQ009473 scl43722.2.1_27 RAS p21 protein activator 1 Rasa1::RAS p21 protein activator 1 -1.898MSQ019682 scl0380773.4_2 RIKEN cDNA 1810035L17 gene 1810035L17Rik::RIKEN cDNA 1810035L17 gene -1.003MSQ022996 scl054384.1_1 myotubularin related protein 7 Mtmr7::myotubularin related protein 7 -2.05MSQ021979 scl054127.2_67 ribosomal protein S28 Rps28::ribosomal protein S28 -1.044MSQ003783 scl46572.5.1_1 sterile alpha motif domain containing 8 Samd8::sterile alpha motif domain containing 8 1.323MSQ022851 scl077134.2_4 heterogeneous nuclear ribonucleoprotein A0 Hnrpa0::heterogeneous nuclear ribonucleoprotein A0 -1.717MSQ019931 scl020005.4_33 ribosomal protein L9 Rpl9::ribosomal protein L9 -1.206MSQ003102 scl9719.1.1_307 vomeronasal 1 receptor, G7 V1rg7::vomeronasal 1 receptor, G7 1.169MSQ034393 scl0004019.1_43 -2.661MSQ021111 scl067988.9_60 RIKEN cDNA A730024F05 gene Txndc10::thioredoxin domain containing 10 -3.298MSQ024861 scl070093.11_3 ubiquitin-conjugating enzyme E2Q (putative) Ube2q::ubiquitin-conjugating enzyme E2Q (putative) 1.142MSQ009923 scl33660.5_397 heme oxygenase (decycling) 1 Hmox1::heme oxygenase (decycling) 1 -1.168MSQ017162 scl43185.2_219 somatostatin receptor 1 Sstr1::somatostatin receptor 1 1.272MSQ017030 scl52721.8.1_207 membrane-spanning 4-domains, subfamily A, member 2 Ms4a2::membrane-spanning 4-domains, subfamily A, member 2 1.174MSQ022487 scl0384817.1_193 RIKEN cDNA 4930448N21 gene 4930448N21Rik::RIKEN cDNA 4930448N21 gene -1.125MSQ023676 scl019231.6_192 prothymosin alpha Ptma::prothymosin alpha -1.36MSQ021262 scl0270106.4_75 ribosomal protein L13 Rpl13::ribosomal protein L13 -1.71MSQ002815 scl31552.8_17 serine protease inhibitor, Kunitz type 2 Spint2::serine protease inhibitor, Kunitz type 2 -1.101MSQ034307 scl000502.1_59 Mus musculus peroxiredoxin 5 (Prdx5), mRNA. Prdx5::peroxiredoxin 5 -1.68MSQ007855 scl54349.2.1_254 RIKEN cDNA 4930554N03 gene 4930554N03Rik::RIKEN cDNA 4930554N03 gene 1.343MSQ013453 scl53400.8.1_51 DNA segment, Chr 19, ERATO Doi 721, expressed D19Ertd721e::DNA segment, Chr 19, ERATO Doi 721, expressed 1.011MSQ018703 scl20532.2.1_2 RIKEN cDNA 4930500J02 gene 4930500J02Rik::RIKEN cDNA 4930500J02 gene 1.535MSQ021514 scl012867.3_17 cytochrome c oxidase, subunit VIIc Cox7c::cytochrome c oxidase, subunit VIIc -1.121MSQ010002 scl46883.13_90 RIKEN cDNA A730032D07 gene Phf21b::PHD finger protein 21B 1.282MSQ029831 scl0014857.1_108 glutathione S-transferase, alpha 1 (Ya) Gsta1::glutathione S-transferase, alpha 1 (Ya) -1.431MSQ025814 scl0245240.1_49 RIKEN cDNA 9930111J21 gene 9930111J21Rik::RIKEN cDNA 9930111J21 gene -4.372MSQ032047 scl0004054.1_5 Mus musculus scavenger receptor class B, member 1 (Scarb1), mRNA.Scarb1::scavenger receptor class B, member 1 -2.258MSQ020321 scl018516.1_119 pre B-cell leukemia transcription factor 3 Pbx3::pre B-cell leukemia transcription factor 3 1.077MSQ035659 scl0003181.1_45 Mus musculus FK506 binding protein 1a (Fkbp1a), mRNA.Fkbp1a::FK506 binding protein 1a -1.038MSQ004489 scl36822.13_234 expressed sequence AI115600 AI115600::expressed sequence AI115600 1.037MSQ028286 scl0067005.2_12 polymerase (RNA) III (DNA directed) polypeptide KPolr3k::polymerase (RNA) III (DNA directed) polypeptide K -4.957MSQ027998 scl00258649.1_102 olfactory receptor 441 Olfr441::olfactory receptor 441 1.204MSQ022221 scl018984.16_308 P450 (cytochrome) oxidoreductase Por::P450 (cytochrome) oxidoreductase -1.054MSQ012218 scl31187.5.1_273 hypothetical protein 4932443D20 4932443D20::hypothetical protein 4932443D20 2.093MSQ018859 scl11028.4.1_36 RIKEN cDNA 2310034O05 gene 2310034O05Rik::RIKEN cDNA 2310034O05 gene -3.372MSQ011288 scl50205.8_548 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 Slc9a3r2::solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2-1.365MSQ027546 scl00269846.1_236 T-cell receptor beta, variable 13 Tcrb-V13::T-cell receptor beta, variable 13 1.041MSQ006997 scl21949.14_406 tripartite motif protein 46 Trim46::tripartite motif protein 46 -1.443MSQ000969 scl41383.7.120_88 aurora kinase B Aurkb::aurora kinase B 1.082MSQ004481 scl4330.1.1_63 olfactory receptor 1087 Olfr1087::olfactory receptor 1087 1.542MSQ003914 scl42961.8.1_47 eukaryotic translation initiation factor 2B, subunit 2 beta Eif2b2::eukaryotic translation initiation factor 2B, subunit 2 beta -1.005MSQ015713 scl33084.6.1_95 RIKEN cDNA 2900092C05 gene 2900092C05Rik::RIKEN cDNA 2900092C05 gene -1.827MSQ032680 scl0002696.1_5 Mus musculus opioid receptor, sigma 1 (Oprs1), mRNA.Oprs1::opioid receptor, sigma 1 -1.58MSQ002582 scl45201.2_40 COMM domain containing 6 Commd6::COMM domain containing 6 1.024MSQ005171 scl47090.1_141 splicing factor 3b, subunit 4 Sf3b4::splicing factor 3b, subunit 4 1.613MSQ028721 scl0022123.1_274 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Psmd3::proteasome (prosome, macropain) 26S subunit, non-ATPase, 3-1.05MSQ020899 scl0227231.17_168 carbamoyl-phosphate synthetase 1 Cps1::carbamoyl-phosphate synthetase 1 -1.1MSQ030870 scl00244183.1_117 RIKEN cDNA A530023O14 gene A530023O14Rik::RIKEN cDNA A530023O14 gene 1.083MSQ017858 scl24899.72.1_88 procollagen, type XVI, alpha 1 Col16a1::procollagen, type XVI, alpha 1 1.181MSQ021928 scl0329358.1_51 hypothetical protein D530008I23 D530008I23::hypothetical protein D530008I23 1.371MSQ002942 scl16275.2_366 adenosine A1 receptor Adora1::adenosine A1 receptor -2.109MSQ028669 scl0093896.1_128 glucagon-like peptide 2 receptor Glp2r::glucagon-like peptide 2 receptor 1.535MSQ023556 scl019243.1_42 protein tyrosine phosphatase 4a1 Ptp4a1::protein tyrosine phosphatase 4a1 -1.202MSQ022476 scl020090.2_29 ribosomal protein S29 Rps29::ribosomal protein S29 -1.692MSQ018972 scl48508.5.1_8 RIKEN cDNA 2310056P07 gene 2310056P07Rik::RIKEN cDNA 2310056P07 gene -1.273MSQ014041 scl26744.20.688_4 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Slc5a6::solute carrier family 5 (sodium-dependent vitamin transporter), member 61.134MSQ008028 scl35466.3.1_11 hypothetical protein E330023G01 E330023G01::hypothetical protein E330023G01 1.111MSQ018948 scl43301.1.2269_3 ganglioside-induced differentiation-associated-protein 10Gdap10::ganglioside-induced differentiation-associated-protein 10 -1.431MSQ010131 scl35255.1_653 RIKEN cDNA D730035F11 gene D730035F11Rik::RIKEN cDNA D730035F11 gene 1.093MSQ011095 scl46752.1.555_0 RIKEN cDNA C430014K11 gene C430014K11Rik::RIKEN cDNA C430014K11 gene 1.939MSQ002522 scl33620.26.1_275 inositol polyphosphate-4-phosphatase, type II Inpp4b::inositol polyphosphate-4-phosphatase, type II -3.403MSQ017392 scl37047.1.6_25 RIKEN cDNA E230034D01 gene E230034D01Rik::RIKEN cDNA E230034D01 gene -2.306MSQ015324 scl30499.14.1_7 ribonuclease/angiogenin inhibitor 1 Rnh1::ribonuclease/angiogenin inhibitor 1 -1.343MSQ002254 scl29519.10.9_31 B-cell receptor-associated protein 37 Bcap37::B-cell receptor-associated protein 37 -1.198MSQ002678 scl34470.5_298 transmembrane 4 superfamily member 11 Tm4sf11::transmembrane 4 superfamily member 11 -2.415MSQ034897 scl0002005.1_36 Mus musculus PHD finger protein 17, mRNA (cDNA clone MGC:31036 IMAGE:5250231), complete cds.Phf17::PHD finger protein 17 2.331MSQ020398 scl016691.2_87 keratin complex 2, basic, gene 8 Krt2-8::keratin complex 2, basic, gene 8 -1.791MSQ033422 scl0002440.1_24 Mus musculus myosin X (Myo10), mRNA. Myo10::myosin X -2.05MSQ029241 scl0056347.2_235 eukaryotic translation initiation factor 3, subunit 8 Eif3s8::eukaryotic translation initiation factor 3, subunit 8 -1.043MSQ016724 scl42616.3_123 neuroblastoma myc-related oncogene 1 Nmyc1::neuroblastoma myc-related oncogene 1 -1.317MSQ005330 scl20184.17.1_283 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 Slc24a3::solute carrier family 24 (sodium/potassium/calcium exchanger), member 31.418MSQ019360 scl018786.2_1 phospholipase A2, activating protein Plaa::phospholipase A2, activating protein -1.178MSQ006171 scl18647.1_62 centromere autoantigen B Cenpb::centromere autoantigen B 1.197MSQ034348 scl000483.1_20 Mus musculus pyruvate carboxylase (Pcx), mRNA.Pcx::pyruvate carboxylase -1.183MSQ014753 scl39206.7_318 cDNA sequence BC017643 BC017643::cDNA sequence BC017643 -1.497MSQ022583 scl071844.3_76 nucleoporin like 1 Nupl1::nucleoporin like 1 -1.091MSQ025245 scl0241118.10_7 amiloride-sensitive cation channel 4, pituitary Accn4::amiloride-sensitive cation channel 4, pituitary -2.573MSQ019626 scl0320330.1_11 RIKEN cDNA A730041O05 gene A730041O05Rik::RIKEN cDNA A730041O05 gene 1.021MSQ026188 scl016415.2_159 integrin beta 2-like Itgb2l::integrin beta 2-like 2.272MSQ022550 scl073713.3_139 RIKEN cDNA 1110018J23 gene 1110018J23Rik::RIKEN cDNA 1110018J23 gene -1.733MSQ011106 scl48261.13.240_30 chaperonin subunit 8 (theta) Cct8::chaperonin subunit 8 (theta) -1.053MSQ017271 scl35505.4.1_127 RIKEN cDNA 1700034K08 gene 1700034K08Rik::RIKEN cDNA 1700034K08 gene 1.083MSQ015359 scl47302.5_94 F-box protein 43 Fbxo43::F-box protein 43 1.138MSQ017353 scl45584.3_58 sal-like 2 (Drosophila) Sall2::sal-like 2 (Drosophila) 1.095MSQ034709 scl0003886.1_50 Mouse hexokinase mRNA, complete cds. Hk1::hexokinase 1 -1.301MSQ010606 scl47780.3.9_1 ribosomal protein L8 Rpl8::ribosomal protein L8 -1.132MSQ011559 scl37331.1.1_31 olfactory receptor 801 Olfr801::olfactory receptor 801 1.554MSQ034129 scl0001024.1_239 Mus musculus Ig kappa germline J-C region: J1-5 and C genes, and flanks. 1.716MSQ009926 scl17505.7.1_8 Fc receptor, IgA, IgM, high affinity Fcamr::Fc receptor, IgA, IgM, high affinity -1.117MSQ009890 scl45928.3.441_22 Zic finger protein of the cerebellum 2 Zic2::Zic finger protein of the cerebellum 2 1.535MSQ028105 scl00209707.1_172 Mblk1-related protein-1 Mlr1::Mblk1-related protein-1 1.911MSQ024546 scl0102866.1_231 plastin 3 (T-isoform) Pls3::plastin 3 (T-isoform) -1.16MSQ000890 scl53290.5_226 RIKEN cDNA 5730446C15 gene 5730446C15Rik::RIKEN cDNA 5730446C15 gene 1.277MSQ005559 scl52380.1.2_114 RIKEN cDNA 4930535F04 gene 4930535F04Rik::RIKEN cDNA 4930535F04 gene 1.434MSQ028860 scl0018194.1_157 NAD(P) dependent steroid dehydrogenase-like Nsdhl::NAD(P) dependent steroid dehydrogenase-like -1.278MSQ024860 scl066845.4_127 mitochondrial ribosomal protein L33 Mrpl33::mitochondrial ribosomal protein L33 -1.109MSQ009389 scl4359.1.1_40 olfactory receptor 995 Olfr995::olfactory receptor 995 1.836MSQ018127 scl39263.5_3 chromobox homolog 4 (Drosophila Pc class) Cbx4::chromobox homolog 4 (Drosophila Pc class) 1.216MSQ010001 scl34180.6.1_91 RIKEN cDNA C330016L05 gene C330016L05Rik::RIKEN cDNA C330016L05 gene -1.509MSQ028925 scl0015519.1_14 heat shock protein 1, alpha Hspca::heat shock protein 1, alpha -1.114MSQ015769 scl33774.7.1_43 RIKEN cDNA 3110005G23 gene 3110005G23Rik::RIKEN cDNA 3110005G23 gene 1.732MSQ012762 scl19557.11_657 Tnf receptor-associated factor 2 Traf2::Tnf receptor-associated factor 2 1.789MSQ007213 scl54410.13_641 cytochrome b-245, beta polypeptide Cybb::cytochrome b-245, beta polypeptide 1.033MSQ027014 scl0070458.2_200 RIKEN cDNA 2610318N02 gene 2610318N02Rik::RIKEN cDNA 2610318N02 gene 1.313MSQ007026 scl30718.8_25 RIKEN cDNA 3230401I01 gene 3230401I01Rik::RIKEN cDNA 3230401I01 gene 1.136MSQ020998 scl076683.1_22 RIKEN cDNA 1500002F19 gene 1500002F19Rik::RIKEN cDNA 1500002F19 gene -1.509MSQ022792 scl0105887.8_170 expressed sequence AI746432 AI746432::expressed sequence AI746432 1.41MSQ002949 scl30200.21.1_7 tripartite motif protein 24 Trim24::tripartite motif protein 24 -3.298MSQ015460 scl38237.12_618 RIKEN cDNA A130090K04 gene A130090K04Rik::RIKEN cDNA A130090K04 gene 1.174MSQ020735 scl067398.15_77 signal recognition particle receptor ('docking protein')Srpr::signal recognition particle receptor ('docking protein') -1.252MSQ027449 scl0053600.1_329 translocase of inner mitochondrial membrane 23 homolog (yeast)Timm23::translocase of inner mitochondrial membrane 23 homolog (yeast)-1.332MSQ022539 scl0258977.1_178 olfactory receptor 1273 Olfr1273::olfactory receptor 1273 1.021MSQ009113 scl50577.16.1_1 thyroid hormone receptor interactor 10 Trip10::thyroid hormone receptor interactor 10 -1.011MSQ025614 scl0107375.1_234 expressed sequence AW491445 AW491445::expressed sequence AW491445 1.649MSQ006636 scl30885.8.9_59 hemopexin Hpxn::hemopexin -1.23MSQ015967 scl18714.45_17 transient receptor potential cation channel, subfamily M, member 7 Trpm7::transient receptor potential cation channel, subfamily M, member 7-2.023MSQ010693 scl38368.11_94 Wnt inhibitory factor 1 Wif1::Wnt inhibitory factor 1 1.069MSQ019413 scl027050.3_42 ribosomal protein S3 Rps3::ribosomal protein S3 -1.468MSQ035795 mtDNA_ND3 1.182MSQ025665 scl016828.6_330 lactate dehydrogenase 1, A chain Ldh1::lactate dehydrogenase 1, A chain -1.228MSQ007548 scl33150.17.997_2 integrin beta 1 (fibronectin receptor beta) Itgb1::integrin beta 1 (fibronectin receptor beta) -1.422MSQ025737 scl078294.3_16 ribosomal protein S27a Rps27a::ribosomal protein S27a -1.19MSQ022008 scl0259067.1_292 olfactory receptor 449 Olfr449::olfactory receptor 449 -1.383MSQ023670 scl074761.10_0 RIKEN cDNA 1200013A08 gene 1200013A08Rik::RIKEN cDNA 1200013A08 gene 1.15MSQ003133 scl32610.6.1_5 RIKEN cDNA 6430529G09 gene 6430529G09Rik::RIKEN cDNA 6430529G09 gene -3.713MSQ020829 scl070270.2_38 RIKEN cDNA 2010205O06 gene 2010205O06Rik::RIKEN cDNA 2010205O06 gene -1.687MSQ014968 scl18934.1_36 RIKEN cDNA 9930117H01 gene 9930117H01Rik::RIKEN cDNA 9930117H01 gene 1.33MSQ019141 scl50214.9.1_45 RIKEN cDNA 1600002H07 gene 1600002H07Rik::RIKEN cDNA 1600002H07 gene 1.013MSQ001884 scl29456.8_67 taste receptor, type 2, member 116 Tas2r116::taste receptor, type 2, member 116 1.513MSQ024075 scl0266692.1_279 copine I Cpne1::copine I 1.338MSQ001045 scl17869.14_197 RIKEN cDNA 2810421I24 gene 2810421I24Rik::RIKEN cDNA 2810421I24 gene 1.339MSQ020155 scl0171250.1_158 vomeronasal 1 receptor, H7 V1rh7::vomeronasal 1 receptor, H7 1.202MSQ007267 scl17283.6_608 solute carrier family 19 (thiamine transporter), member 2 Slc19a2::solute carrier family 19 (thiamine transporter), member 2-1.059MSQ029848 scl00235293.2_55 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) Sc5d::sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)-1.003MSQ019077 scl071245.8_9 RIKEN cDNA 4933428F06 gene 4933428F06Rik::RIKEN cDNA 4933428F06 gene 2.453MSQ036086 mmu-miR-191.miRNA-Tagged-Template -2.465MSQ031041 scl0014719.1_330 glutamate oxaloacetate transaminase 2, mitochondrial Got2::glutamate oxaloacetate transaminase 2, mitochondrial -1.472MSQ001874 scl39299.4_652 cytoglobin Cygb::cytoglobin 1.044MSQ003240 scl27725.2.1_9 RIKEN cDNA 1700071G01 gene 1700071G01Rik::RIKEN cDNA 1700071G01 gene -1.604MSQ025456 scl0320944.1_16 RIKEN cDNA D130033C15 gene D130033C15Rik::RIKEN cDNA D130033C15 gene -1.213MSQ020833 scl0116731.1_261 protocadherin alpha 1 Pcdha1::protocadherin alpha 1 -2.787MSQ034539 scl0003479.1_30 Mus musculus cDNA sequence BC010801 (BC010801), mRNA.BC010801::cDNA sequence BC010801 -4.75MSQ030095 scl00110323.1_173 cytochrome c oxidase, subunit VIb Cox6b1::cytochrome c oxidase, subunit VIb polypeptide 1 -1.281MSQ030211 scl00209225.2_155 RIKEN cDNA 5430400N05 gene 5430400N05Rik::RIKEN cDNA 5430400N05 gene -3.163MSQ028130 scl00227525.1_330 DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) Dclre1c::DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) 3.222MSQ010760 scl29739.10.1_239 RIKEN cDNA C130022K22 gene C130022K22Rik::RIKEN cDNA C130022K22 gene 1.004MSQ011709 scl38700.8_158 WD repeat domain 18 Wdr18::WD repeat domain 18 -1.372MSQ015605 scl21064.31_2 RIKEN cDNA 5830434P21 gene 5830434P21Rik::RIKEN cDNA 5830434P21 gene 1.033MSQ003968 scl31501.6.1_29 FXYD domain-containing ion transport regulator 7 Fxyd7::FXYD domain-containing ion transport regulator 7 -2.165MSQ023573 scl018479.15_43 p21 (CDKN1A)-activated kinase 1 Pak1::p21 (CDKN1A)-activated kinase 1 1.263MSQ022039 scl083962.1_77 BTB (POZ) domain containing 1 Btbd1::BTB (POZ) domain containing 1 -1.135MSQ013282 scl29524.1.31_83 RIKEN cDNA D830015G05 gene D830015G05Rik::RIKEN cDNA D830015G05 gene -2.635MSQ002049 scl24682.1.1_14 RIKEN cDNA D030004A10 gene D030004A10Rik::RIKEN cDNA D030004A10 gene -2.191MSQ028768 scl0069965.1_249 RIKEN cDNA 2810403D23 gene 2810403D23Rik::RIKEN cDNA 2810403D23 gene 1.313MSQ010973 scl35879.4_19 succinate dehydrogenase complex, subunit D, integral membrane protein Sdhd::succinate dehydrogenase complex, subunit D, integral membrane protein-1.085MSQ014703 scl44287.1.1_125 hypothetical protein A630043P06 A630043P06::hypothetical protein A630043P06 1.367MSQ012961 scl23026.14.1_6 Fc receptor-like protein 3 Fcrl5::Fc receptor-like protein 5 -1.809MSQ016570 scl38114.7.1_13 arginase 1, liver Arg1::arginase 1, liver -1.623MSQ019350 scl067387.5_4 unc-50 homolog (C. elegans) Unc50::unc-50 homolog (C. elegans) -1.215MSQ021107 scl0404317.1_84 olfactory receptor 592 Olfr592::olfactory receptor 592 1.084MSQ024002 scl0208869.1_9 dedicator of cyto-kinesis 3 Dock3::dedicator of cyto-kinesis 3 1.246MSQ016471 scl48614.17_462 leprecan-like 1 Leprel1::leprecan-like 1 2.533MSQ022652 scl0331547.1_266 hypothetical protein C130073P14 C130073P14::hypothetical protein C130073P14 -3.089MSQ018313 scl26851.20.1_3 prestin (motor protein) Pres::prestin (motor protein) -1.75MSQ006278 scl50930.18_166 ankyrin repeat and SAM domain containing 1 Anks1::ankyrin repeat and SAM domain containing 1 1.142MSQ022889 scl076478.1_164 RIKEN cDNA 2410004L22 gene 2410004L22Rik::RIKEN cDNA 2410004L22 gene 1.08MSQ032895 scl000668.1_6 Mus musculus RIKEN cDNA 9430041O17 gene (9430041O17Rik), mRNA. -1.05MSQ016745 scl6624.1.1_36 olfactory receptor 935 Olfr935::olfactory receptor 935 1.042MSQ025982 scl0171195.1_20 vomeronasal 1 receptor, C22 V1rc22::vomeronasal 1 receptor, C22 1.947MSQ021466 scl013121.10_1 cytochrome P450, family 51 Cyp51::cytochrome P450, family 51 -1.623MSQ033846 scl0004173.1_12 Mus musculus beta-glucuronidase (Gus), mRNA. Gusb::glucuronidase, beta 1.05MSQ015417 scl53963.7.84_73 RIKEN cDNA 4921520P21 gene 4921520P21Rik::RIKEN cDNA 4921520P21 gene 1.034MSQ026273 scl0017720.1_306 NADH dehydrogenase 4L, mitochondrial mt-Nd4l::NADH dehydrogenase 4L, mitochondrial 1.04MSQ030503 scl0067732.1_253 RIKEN cDNA 4833421E05 gene 4833421E05Rik::RIKEN cDNA 4833421E05 gene -2.174MSQ009369 scl27377.5.1_10 RIKEN cDNA 2210016L21 gene 2210016L21Rik::RIKEN cDNA 2210016L21 gene -1.602MSQ012474 scl33015.27.238_51 symplekin Sympk::symplekin -1.23MSQ000906 scl54746.4.1_97 myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog (Drosophila)Mllt7::myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog (Drosophila)-1.924MSQ019348 scl0277753.12_27 similar to cytochrome P450, 4a10 MGC25972::similar to cytochrome P450, 4a10 1.546MSQ010566 scl38703.5.1_6 adipsin Adn::adipsin -2.465MSQ022362 scl013132.15_5 disabled homolog 2 (Drosophila) Dab2::disabled homolog 2 (Drosophila) 1.249MSQ008540 scl13068.1.1_24 olfactory receptor 378 Olfr378::olfactory receptor 378 1.098MSQ020085 scl011816.1_11 apolipoprotein E Apoe::apolipoprotein E -1.254MSQ007299 scl41744.13_26 reticulon 4 Rtn4::reticulon 4 1.117MSQ020375 scl072313.2_0 RIKEN cDNA 2510002A14 gene 2510002A14Rik::RIKEN cDNA 2510002A14 gene -1.486MSQ014952 scl46368.7_1 purine-nucleoside phosphorylase Pnp::purine-nucleoside phosphorylase 1.124MSQ019711 scl0224105.1_51 p21 (CDKN1A)-activated kinase 2 Pak2::p21 (CDKN1A)-activated kinase 2 1.542MSQ008063 scl30697.1.1_18 exportin 6 Xpo6::exportin 6 -3.073MSQ021923 scl015364.1_19 high mobility group AT-hook 2 Hmga2::high mobility group AT-hook 2 -2.465MSQ011606 scl22584.20.1_20 centromere protein E Cenpe::centromere protein E -1.442MSQ032019 scl000825.1_3 Mus musculus cyclin T2, mRNA (cDNA clone MGC:59590 IMAGE:6509024), complete cds.Ccnt2::cyclin T2 1.429MSQ004967 scl23651.2_563 cDNA sequence BC059177 BC059177::cDNA sequence BC059177 1.28MSQ008226 scl31911.1.1_45 olfactory receptor 45 Olfr45::olfactory receptor 45 1.044MSQ026482 scl0051810.1_209 heterogeneous nuclear ribonucleoprotein U Hnrpu::heterogeneous nuclear ribonucleoprotein U -1.17MSQ017174 scl51417.1.32_38 haloacid dehalogenase-like hydrolase domain Hdhd1a::haloacid dehalogenase-like hydrolase domain -1.22MSQ013291 scl23771.9.1_58 eukaryotic translation initiation factor 3, subunit 2 (beta) Eif3s2::eukaryotic translation initiation factor 3, subunit 2 (beta) -1.054MSQ032372 scl0003718.1_141 Mus musculus muted (Muted), mRNA. Muted::muted 1.758MSQ000289 NM_019642.17|chr2|+|159183272|159183880_222Mus musculus ribophorin II (Rpn2), mRNA. Rpn2::ribophorin II -1.301MSQ017258 scl36328.1.1_139 RIKEN cDNA C230053D17 gene C230053D17Rik::RIKEN cDNA C230053D17 gene 1.225MSQ006081 scl52035.9_35 Nedd4 family interacting protein 1 Ndfip1::Nedd4 family interacting protein 1 -1.324MSQ000846 scl52665.13.1_14 aldehyde dehydrogenase family 1, subfamily A7 Aldh1a7::aldehyde dehydrogenase family 1, subfamily A7 -1.04MSQ017625 scl32353.2.4_40 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 Ndufc2::NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2-1.017MSQ011202 scl18438.1.86_9 RIKEN cDNA 4930405A21 gene 4930405A21Rik::RIKEN cDNA 4930405A21 gene -5.079MSQ004567 scl48237.1.1_101 keratin associated protein 16-4 Krtap16-4::keratin associated protein 16-4 -1.05MSQ011963 scl50306.11.1_132 solute carrier family 22 (organic cation transporter), member 1 Slc22a1::solute carrier family 22 (organic cation transporter), member 1-1.165MSQ028971 scl0071879.1_113 acyl-CoA synthetase long-chain family member 5 Acsl5::acyl-CoA synthetase long-chain family member 5 -1.621MSQ017010 scl21793.3_27 B-cell CLL/lymphoma 9 Bcl9::B-cell CLL/lymphoma 9 1.76MSQ006192 scl44493.21_209 procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein Col4a3bp::procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein-4.323MSQ023658 scl071270.1_191 RIKEN cDNA 4933438K21 gene 4933438K21Rik::RIKEN cDNA 4933438K21 gene 1.687MSQ003242 scl45212.1.365_19 Kruppel-like factor 12 Klf12::Kruppel-like factor 12 -1.232MSQ013229 scl46654.8.1_7 protein phosphatase 1, regulatory (inhibitor) subunit 1A Ppp1r1a::protein phosphatase 1, regulatory (inhibitor) subunit 1A -1.663MSQ015447 scl46854.10.1_20 expressed sequence AI451006 AI451006::expressed sequence AI451006 -1.05MSQ029830 scl0081842.1_155 immediate early response, erythropoietin 2 Ierepo2::immediate early response, erythropoietin 2 1.113MSQ021737 scl014724.1_74 glycoprotein Ib, beta polypeptide Gp1bb::glycoprotein Ib, beta polypeptide -4.079MSQ005587 scl26079.14.13_4 RIKEN cDNA 0610039P13 gene 0610039P13Rik::RIKEN cDNA 0610039P13 gene -2.372MSQ032004 scl0001333.1_125 -1.171MSQ006678 scl54887.3.1_181 RIKEN cDNA 1700030B21 gene 1700030B21Rik::RIKEN cDNA 1700030B21 gene 1.052MSQ015451 scl29419.1_304 hypothetical protein E130307C13 E130307C13::hypothetical protein E130307C13 1.056MSQ003357 scl15933.11.1_5 lymphocyte antigen 9 Ly9::lymphocyte antigen 9 1.13MSQ016143 scl32059.2.1_50 RIKEN cDNA D930031A20 gene D930031A20Rik::RIKEN cDNA D930031A20 gene 1.045MSQ032733 scl0001943.1_55 Mus musculus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 (Smarca3), mRNA.Smarca3::SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 31.142MSQ016582 scl24615.5.1_59 RIKEN cDNA 1500011L16 gene 1500011L16Rik::RIKEN cDNA 1500011L16 gene -1.382MSQ013257 scl31419.6.1_14 RIKEN cDNA 1700028J19 gene 1700028J19Rik::RIKEN cDNA 1700028J19 gene -2.22MSQ015966 scl30032.3.1_35 hypothetical protein D430007I03 D430007I03::hypothetical protein D430007I03 1.053MSQ009427 scl41232.2.1_8 RIKEN cDNA 2210008F06 gene 2210008F06Rik::RIKEN cDNA 2210008F06 gene 2.172MSQ008296 scl19835.1_73 RNA-binding region (RNP1, RRM) containing 1 Rnpc1::RNA-binding region (RNP1, RRM) containing 1 -3.209MSQ027057 scl0067684.1_211 RIKEN cDNA 3300001P08 gene 3300001P08Rik::RIKEN cDNA 3300001P08 gene -1.056MSQ001526 scl00267019.1_256 Mus musculus ribosomal protein S15a (Rps15a), mRNA.Rps15a::ribosomal protein S15a 1.783MSQ022084 scl075608.7_106 RIKEN cDNA 2010012F05 gene Chmp4b::chromatin modifying protein 4B -1.04MSQ021786 scl0213673.3_37 RIKEN cDNA 9530068E07 gene 9530068E07Rik::RIKEN cDNA 9530068E07 gene -1.036MSQ007886 scl40512.21.1_20 dopa decarboxylase Ddc::dopa decarboxylase -1.05MSQ011209 scl34046.2_46 DNA segment, Chr 8, ERATO Doi 457, expressed D8Ertd457e::DNA segment, Chr 8, ERATO Doi 457, expressed -2.202MSQ030161 scl00224598.1_163 cDNA sequence BC021442 BC021442::cDNA sequence BC021442 1.079MSQ002940 scl19166.7.1_31 RIKEN cDNA 2810410A08 gene 2810410A08Rik::RIKEN cDNA 2810410A08 gene -2.237MSQ003569 scl31415.7_3 RIKEN cDNA 2310044H10 gene 2310044H10Rik::RIKEN cDNA 2310044H10 gene -1.105MSQ003500 scl23487.8.3034_55 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)H6pd::hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)-1.047MSQ002560 scl53074.18_38 STE20-like kinase (yeast) Slk::STE20-like kinase (yeast) -3.137MSQ012054 scl50762.2_0 immediate early response 3 Ier3::immediate early response 3 -1.195MSQ014893 scl4941.1.1_206 olfactory receptor 1015 Olfr1015::olfactory receptor 1015 1.092MSQ009138 scl54435.12.1_121 Wiskott-Aldrich syndrome homolog (human) Was::Wiskott-Aldrich syndrome homolog (human) 1.584MSQ009087 scl33609.11.1_6 RIKEN cDNA 4933434I20 gene 4933434I20Rik::RIKEN cDNA 4933434I20 gene -3.019MSQ026640 scl0020347.2_287 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Sema3b::sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B-1.278MSQ025849 scl0258295.1_49 olfactory receptor 746 Olfr746::olfactory receptor 746 2.061MSQ020782 scl028033.1_31 DNA segment, Chr 2, Wayne State University 131, expressed Csrp2bp::cysteine and glycine-rich protein 2 binding protein 1.179MSQ005183 scl31384.10.152_39 CD37 antigen Cd37::CD37 antigen -3.924MSQ034011 scl0001960.1_46 Mucin 1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).Muc1::mucin 1, transmembrane 1.156MSQ028820 scl0074399.1_313 RIKEN cDNA 4933403O03 gene 4933403O03Rik::RIKEN cDNA 4933403O03 gene 1.588MSQ035625 scl000114.1_3 Mus musculus leucine carboxyl methyltransferase 1 (Lcmt1), mRNA.Lcmt1::leucine carboxyl methyltransferase 1 1.25MSQ003519 scl42706.1.1_221 RIKEN cDNA 2310058N22 gene 2310058N22Rik::RIKEN cDNA 2310058N22 gene -4.713MSQ030948 scl00108012.1_23 adaptor-related protein complex 1, sigma 2 subunit Ap1s2::adaptor-related protein complex 1, sigma 2 subunit -2.403MSQ015722 scl19849.2.1_147 RIKEN cDNA 1700007M16 gene 1700007M16Rik::RIKEN cDNA 1700007M16 gene -1.05MSQ003339 scl21952.1_54 farnesyl diphosphate synthetase Fdps::farnesyl diphosphate synthetase 1.371MSQ027469 scl0013525.1_185 a disintegrin and metalloprotease domain 26 (testase 3)Adam26::a disintegrin and metalloprotease domain 26 (testase 3) 1.148MSQ021296 scl0384061.7_167 fibronectin type III domain containing 5 Fndc5::fibronectin type III domain containing 5 -3.635MSQ031267 scl0003489.1_17 Mus musculus RIKEN cDNA D430025H09 gene (D430025H09Rik), mRNA.D430025H09Rik::RIKEN cDNA D430025H09 gene 1.623MSQ010206 scl25554.2.1_0 RIKEN cDNA 1700009N14 gene 1700009N14Rik::RIKEN cDNA 1700009N14 gene -1.005MSQ009311 scl1590.1.1_172 RIKEN cDNA C030013C02 gene C030013C02Rik::RIKEN cDNA C030013C02 gene 1.04MSQ029942 scl0069504.2_283 RIKEN cDNA 2310001H12 gene 2310001H12Rik::RIKEN cDNA 2310001H12 gene 1.025MSQ024205 scl0382056.1_112 expressed sequence AI413414 Mect1::mucoepidermoid carcinoma translocated 1 -2.102MSQ026921 scl0019087.2_280 protein kinase, cAMP dependent regulatory, type II alpha Prkar2a::protein kinase, cAMP dependent regulatory, type II alpha -1.216MSQ023472 scl019276.23_1 protein tyrosine phosphatase, receptor type, N polypeptide 2 Ptprn2::protein tyrosine phosphatase, receptor type, N polypeptide 2-1.237MSQ017562 scl24530.11.1_23 receptor (TNFRSF)-interacting serine-threonine kinase 2Ripk2::receptor (TNFRSF)-interacting serine-threonine kinase 2 -1.787MSQ032520 scl000961.1_62 Mus musculus protoporphyrinogen oxidase (Ppox), mRNA.Ppox::protoporphyrinogen oxidase -1.433MSQ032708 scl000324.1_53 Mus musculus adrenergic receptor, alpha 1a (Adra1a), mRNA.Adra1a::adrenergic receptor, alpha 1a -1.465MSQ027835 scl0072293.2_258 naked cuticle 2 homolog (Drosophila) Nkd2::naked cuticle 2 homolog (Drosophila) -1.773MSQ028875 scl00320476.1_115 RIKEN cDNA 2610020C11 gene 2610020C11Rik::RIKEN cDNA 2610020C11 gene -1.666MSQ015141 scl34736.1_398 RIKEN cDNA 9530019H20 gene 9530019H20Rik::RIKEN cDNA 9530019H20 gene 1.878MSQ015692 scl32247.1.1_235 olfactory receptor 669 Olfr669::olfactory receptor 669 1.103MSQ014291 scl40787.10.7_5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Psmd12::proteasome (prosome, macropain) 26S subunit, non-ATPase, 12-1.164MSQ032811 scl000387.1_183 Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330137F24 product:SYNAPTORIN homolog [Rattus norvegicus], full insert sequence.Synpr::synaptoporin 1.54MSQ022328 scl070065.1_67 RIKEN cDNA 1700030G11 gene 1700030G11Rik::RIKEN cDNA 1700030G11 gene -2.093MSQ033161 scl0003103.1_727 Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530084A18 product:unclassifiable, full insert sequence.Prkcbp1::protein kinase C binding protein 1 1.311MSQ013760 scl50602.12.1_148 hepatoma-derived growth factor, related protein 2 Hdgfrp2::hepatoma-derived growth factor, related protein 2 1.396MSQ010700 scl22020.8.1_30 fibrinogen, B beta polypeptide Fgb::fibrinogen, B beta polypeptide 1.119MSQ018399 scl600.1.1_68 olfactory receptor 165 Olfr165::olfactory receptor 165 1.996MSQ023860 scl078900.1_196 RIKEN cDNA 9130024F11 gene 9130024F11Rik::RIKEN cDNA 9130024F11 gene -1.04MSQ006349 scl22787.1.77_17 RIKEN cDNA 8030451N04 gene 8030451N04Rik::RIKEN cDNA 8030451N04 gene 1.124MSQ031873 scl0001820.1_53 MKIAA1019 protein (Fragment). Son::Son cell proliferation protein 2.301MSQ013165 scl45563.11.1_75 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Slc7a8::solute carrier family 7 (cationic amino acid transporter, y+ system), member 81.215MSQ013334 scl53350.20_138 expressed sequence AV312086 AV312086::expressed sequence AV312086 1.043MSQ031830 scl000522.1_26 Mus musculus PRP19/PSO4 homolog (S. cerevisiae) (Prp19), mRNA.Prp19::PRP19/PSO4 homolog (S. cerevisiae) -1.007MSQ022063 scl0382019.3_116 similar to hypothetical protein FLJ38281 LOC382019::similar to hypothetical protein FLJ38281 -1.05MSQ009134 scl16789.34_226 myosin IB Myo1b::myosin IB -1.318MSQ006862 scl24658.9.1_90 tumor necrosis factor receptor superfamily, member 25 Tnfrsf25::tumor necrosis factor receptor superfamily, member 25 1.501MSQ002415 scl25220.23.1_99 leptin receptor Lepr::leptin receptor -3.165MSQ011634 scl47190.1_370 RIKEN cDNA A430088I17 gene A430088I17Rik::RIKEN cDNA A430088I17 gene 1.279MSQ016601 scl45711.13.1_4 RIKEN cDNA 2900054P12 gene Gcap14::granule cell antiserum positive 14 -1.139MSQ027675 scl0012870.2_25 ceruloplasmin Cp::ceruloplasmin -1.004MSQ019769 scl077920.4_150 RIKEN cDNA A330102I10 gene A330102I10Rik::RIKEN cDNA A330102I10 gene -2.117MSQ012090 scl52780.10_0 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 Slc3a2::solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 21.371MSQ002644 scl32240.5.1_5 sphingomyelin phosphodiesterase 1, acid lysosomal Smpd1::sphingomyelin phosphodiesterase 1, acid lysosomal -1.105MSQ020821 scl053881.1_71 solute carrier family 5 (inositol transporters), member 3 Slc5a3::solute carrier family 5 (inositol transporters), member 3 3.12MSQ005140 scl43241.1.1_122 hypothetical protein D930001B02 D930001B02::hypothetical protein D930001B02 -1.021MSQ021606 scl057294.3_33 ribosomal protein S27 Rps27::ribosomal protein S27 -1.106MSQ025663 scl0269060.1_7 neural stem cell-derived dendrite regulator Nsddr::neural stem cell-derived dendrite regulator -4.395MSQ011948 scl31869.6.1_15 troponin I, skeletal, fast 2 Tnni2::troponin I, skeletal, fast 2 1.08MSQ035859 scl0000115.1_6_REVCOMP 1.945MSQ026724 scl00319202.1_96 RIKEN cDNA 1200016E24 gene 1200016E24Rik::RIKEN cDNA 1200016E24 gene -1.277MSQ009065 scl22477.8.1_16 urate oxidase Uox::urate oxidase -1.106MSQ015901 scl19164.4.1_99 RIKEN cDNA 1500002O10 gene 1500002O10Rik::RIKEN cDNA 1500002O10 gene 3.502MSQ019594 scl014182.16_37 fibroblast growth factor receptor 1 Fgfr1::fibroblast growth factor receptor 1 -1.654MSQ020129 scl0235327.4_330 hypothetical protein A430041E03 A430041E03::hypothetical protein A430041E03 1.034MSQ025532 scl019045.1_99 protein phosphatase 1, catalytic subunit, alpha isoform Ppp1ca::protein phosphatase 1, catalytic subunit, alpha isoform -1.148MSQ026605 scl0030928.2_140 zinc finger protein 238 Zfp238::zinc finger protein 238 1.369MSQ007366 scl47658.1.1_117 RIKEN cDNA A930031G03 gene A930031G03Rik::RIKEN cDNA A930031G03 gene 1.183MSQ026338 scl0017114.1_8 mannose-6-phosphate receptor, pseudogene M6pr-ps::mannose-6-phosphate receptor, pseudogene -1.608MSQ022079 scl056348.1_132 hydroxysteroid (17-beta) dehydrogenase 12 Hsd17b12::hydroxysteroid (17-beta) dehydrogenase 12 -1.287MSQ008813 scl6269.2.1_148 RIKEN cDNA D330038K10 gene D330038K10Rik::RIKEN cDNA D330038K10 gene -1.05MSQ001778 scl50061.5_465 RIKEN cDNA 9030612M13 gene 9030612M13Rik::RIKEN cDNA 9030612M13 gene 1.246MSQ034717 scl0003531.1_19 Mus musculus adult male lung cDNA, RIKEN full-length enriched library, clone:1200013C18 product:kelch-like ECH-associated protein 1, full insert sequence.Keap1::kelch-like ECH-associated protein 1 3.082MSQ003124 scl51521.7_200 RIKEN cDNA 2610307O08 gene 2610307O08Rik::RIKEN cDNA 2610307O08 gene 1.431MSQ021112 scl012969.3_264 crystallin, gamma F Crygf::crystallin, gamma F 1.228MSQ010434 scl27736.9.1_26 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1 Gabrb1::gamma-aminobutyric acid (GABA-A) receptor, subunit beta 11.49MSQ021287 scl054624.14_263 RIKEN cDNA 5730511K23 gene 5730511K23Rik::RIKEN cDNA 5730511K23 gene -2.377MSQ014905 scl49586.23.1_29 expressed sequence AW494914 AW494914::expressed sequence AW494914 -1.084MSQ007252 scl8638.1.1_202 vomeronasal 1 receptor, E5 V1re5::vomeronasal 1 receptor, E5 1.842MSQ012651 scl2336.2.1_13 RIKEN cDNA 2810439L12 gene 2810439L12Rik::RIKEN cDNA 2810439L12 gene 1.482MSQ016072 scl28694.3.6_18 RIKEN cDNA 1110067M19 gene 1110067M19Rik::RIKEN cDNA 1110067M19 gene 1.394MSQ008606 scl26388.10_270 betacellulin, epidermal growth factor family member Btc::betacellulin, epidermal growth factor family member 1.012MSQ019485 scl074111.25_119 RNA binding motif protein 19 Rbm19::RNA binding motif protein 19 -1.245MSQ005215 scl36724.29_71 neural precursor cell expressed, developmentally down-regulted gene 4 Nedd4::neural precursor cell expressed, developmentally down-regulted gene 4-1.009MSQ003856 scl48631.9_71 replication factor C (activator 1) 4 Rfc4::replication factor C (activator 1) 4 -2.924MSQ030310 scl0013085.1_15 cytochrome P450, family 2, subfamily a, polypeptide 12 Cyp2a12::cytochrome P450, family 2, subfamily a, polypeptide 12 -1.391MSQ028476 scl00258234.1_314 olfactory receptor 1061 Olfr1061::olfactory receptor 1061 -2.272MSQ010116 scl51377.2.1_209 RIKEN cDNA 4833419K08 gene 4833419K08Rik::RIKEN cDNA 4833419K08 gene 1.12MSQ024691 scl067941.3_4 ribosomal protein S27-like Rps27l::ribosomal protein S27-like -1.004MSQ016925 scl27277.1.1_326 RIKEN cDNA 4930477O15 gene 4930477O15Rik::RIKEN cDNA 4930477O15 gene 1.088MSQ031658 scl0002122.1_17 Mus musculus protein kinase Myak-S (Myak) mRNA, alternatively spliced, complete cds.Hipk1::homeodomain interacting protein kinase 1 1.023MSQ022099 scl0246257.1_125 candidate tumor suppressor OVCA2 Ovca2::candidate tumor suppressor OVCA2 1.48MSQ007288 scl27243.1.1_51 RIKEN cDNA 5830487J09 gene 5830487J09Rik::RIKEN cDNA 5830487J09 gene -1.075MSQ009124 scl37277.9.1_0 sestrin 3 Sesn3::sestrin 3 -2.33MSQ025125 scl017356.2_28 myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog (Drosophila)Mllt4::myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog (Drosophila)-1.356MSQ012554 scl37112.9_269 endothelial cell-specific adhesion molecule Esam1::endothelial cell-specific adhesion molecule 1.486MSQ019859 scl011799.1_11 baculoviral IAP repeat-containing 5 Birc5::baculoviral IAP repeat-containing 5 -2.552MSQ023142 scl0319163.1_92 histone 1, H2aa Hist1h2aa::histone 1, H2aa -1.687MSQ022740 scl023918.12_65 inosine 5'-phosphate dehydrogenase 2 Impdh2::inosine 5'-phosphate dehydrogenase 2 -1.028MSQ005560 scl20333.19.1_3 ubiquitin specific protease 8 Usp8::ubiquitin specific protease 8 -1.019MSQ026111 scl019933.5_3 ribosomal protein L21 Rpl21::ribosomal protein L21 -1.401MSQ001879 scl28548.7_53 calcium/calmodulin-dependent protein kinase I Camk1::calcium/calmodulin-dependent protein kinase I 1.77MSQ023121 scl057808.2_82 ribosomal protein L35a Rpl35a::ribosomal protein L35a -1.1MSQ003555 scl43399.8_287 matrilin 3 Matn3::matrilin 3 -2.757MSQ018960 scl0319626.1_30 RIKEN cDNA 9530059O14 gene 9530059O14Rik::RIKEN cDNA 9530059O14 gene -1.169MSQ023559 scl0319358.2_77 RIKEN cDNA C530047H08 gene C530047H08Rik::RIKEN cDNA C530047H08 gene 2.089MSQ029354 scl0074439.1_220 zinc finger, X-linked, duplicated A Zxda::zinc finger, X-linked, duplicated A 1.088MSQ004496 scl35154.1.15_20 RIKEN cDNA 2400009B08 gene 2400009B08Rik::RIKEN cDNA 2400009B08 gene 1.014MSQ023965 scl0319995.1_17 RNA binding motif protein 16 Rbm16::RNA binding motif protein 16 -3.447MSQ025786 scl020104.1_26 ribosomal protein S6 Rps6::ribosomal protein S6 -1.381MSQ001802 scl4937.1.1_26 olfactory receptor 1022 Olfr1022::olfactory receptor 1022 1.159MSQ007259 scl30749.5_442 G protein-coupled receptor, family C, group 5, member B Gprc5b::G protein-coupled receptor, family C, group 5, member B -2.465MSQ008281 scl33301.5.15_0 nudix (nucleoside diphosphate linked moiety X)-type motif 7Nudt7::nudix (nucleoside diphosphate linked moiety X)-type motif 71.179MSQ025754 scl0218885.8_148 cDNA sequence BC019806 BC019806::cDNA sequence BC019806 -1.42MSQ008776 scl36817.19_229 dipeptidylpeptidase 8 Dpp8::dipeptidylpeptidase 8 1.021MSQ034655 scl0003227.1_53 -1.609MSQ005423 scl46621.4.1_1 RIKEN cDNA A430083B19 gene A430083B19Rik::RIKEN cDNA A430083B19 gene -2.465MSQ022014 scl0258186.4_125 olfactory receptor 75, pseudogene 1 Olfr75-ps1::olfactory receptor 75, pseudogene 1 1.891MSQ023972 scl069303.1_139 RIKEN cDNA 1700001G11 gene 1700001G11Rik::RIKEN cDNA 1700001G11 gene 1.049MSQ026875 scl00320841.1_106 RIKEN cDNA 9230115F04 gene 9230115F04Rik::RIKEN cDNA 9230115F04 gene -1.143MSQ030016 scl00380752.1_280 tumor suppressing subtransferable candidate 1 Tssc1::tumor suppressing subtransferable candidate 1 -1.361MSQ001259 scl00319158.2_61 Mus musculus histone 1, H4i (Hist1h4i), mRNA. Hist1h4i::histone 1, H4i -1.178MSQ024309 scl011814.2_27 apolipoprotein C-III Apoc3::apolipoprotein C-III -1.402MSQ003345 scl22898.10_430 regulatory factor X, 5 (influences HLA class II expression) Rfx5::regulatory factor X, 5 (influences HLA class II expression) 1.327MSQ008647 scl40176.2_565 RIKEN cDNA 2310058D17 gene 2310058D17Rik::RIKEN cDNA 2310058D17 gene 1.673MSQ030392 scl00113868.1_328 acetyl-Coenzyme A acyltransferase 1 Acaa1::acetyl-Coenzyme A acyltransferase 1 -1.117MSQ015768 scl2284.1.1_26 olfactory receptor 1342 Olfr1342::olfactory receptor 1342 1.285MSQ015675 scl38270.7_86 DnaJ (Hsp40) homolog, subfamily C, member 14 Dnajc14::DnaJ (Hsp40) homolog, subfamily C, member 14 1.002MSQ004178 scl54454.18.1_68 chloride channel 5 Clcn5::chloride channel 5 -1.086MSQ007487 scl17197.4_15 transgelin 2 Tagln2::transgelin 2 1.256MSQ009325 scl34499.5.1_0 Iroquois related homeobox 3 (Drosophila) Irx3::Iroquois related homeobox 3 (Drosophila) 1.482MSQ014332 scl26669.2.1_184 RIKEN cDNA 1700061D14 gene 1700061D14Rik::RIKEN cDNA 1700061D14 gene 1.211MSQ016240 scl29945.5_360 RIKEN cDNA A930038C07 gene A930038C07Rik::RIKEN cDNA A930038C07 gene -1.528MSQ020225 scl0211100.1_8 RIKEN cDNA A230048G03 gene A230048G03Rik::RIKEN cDNA A230048G03 gene -2.58MSQ024662 scl076628.1_123 RIKEN cDNA 1700112J16 gene 1700112J16Rik::RIKEN cDNA 1700112J16 gene 1.301MSQ018327 scl46194.3.1_127 cDNA sequence BC024502 BC024502::cDNA sequence BC024502 -2.153MSQ027142 scl0053379.2_251 heterogeneous nuclear ribonucleoprotein A2/B1 Hnrpa2b1::heterogeneous nuclear ribonucleoprotein A2/B1 -1.557MSQ009913 scl37714.6_223 guanine nucleotide binding protein (G protein), gamma 7 subunit Gng7::guanine nucleotide binding protein (G protein), gamma 7 subunit2.343MSQ001135 scl29513.8_8 RIKEN cDNA C530028O21 gene C530028O21Rik::RIKEN cDNA C530028O21 gene 1.359MSQ024455 scl0319554.7_300 isopentenyl-diphosphate delta isomerase Idi1::isopentenyl-diphosphate delta isomerase -1.78MSQ015859 scl47326.13.2_27 chaperonin subunit 5 (epsilon) Cct5::chaperonin subunit 5 (epsilon) -1.072MSQ012386 scl4295.1.1_194 olfactory receptor 1214 Olfr1214::olfactory receptor 1214 1.179MSQ004574 scl33717.4.1_13 RIKEN cDNA 2410018E23 gene 2410018E23Rik::RIKEN cDNA 2410018E23 gene -2.75MSQ004742 scl37095.1.1_9 olfactory receptor 902 Olfr902::olfactory receptor 902 1.667MSQ028187 scl0017769.1_244 5,10-methylenetetrahydrofolate reductase Mthfr::5,10-methylenetetrahydrofolate reductase -3.352MSQ021693 scl0208117.1_319 hypothetical protein 4632417K02 Aph1b::anterior pharynx defective 1b homolog (C. elegans) -3.552MSQ021043 scl0258304.1_80 olfactory receptor 498 Olfr498::olfactory receptor 498 -1.626MSQ023782 scl070257.1_12 RIKEN cDNA 2010107E04 gene 2010107E04Rik::RIKEN cDNA 2010107E04 gene -1.053MSQ023050 scl012583.1_32 cysteine dioxygenase 1, cytosolic Cdo1::cysteine dioxygenase 1, cytosolic -1.433MSQ008691 scl8636.1.1_326 vomeronasal 1 receptor, E2 V1re2::vomeronasal 1 receptor, E2 1.042MSQ024909 scl0319960.3_96 RIKEN cDNA 4930513N10 gene 4930513N10Rik::RIKEN cDNA 4930513N10 gene -1.465MSQ004775 scl39873.10.1_46 lectin, galactose binding, soluble 9 Lgals9::lectin, galactose binding, soluble 9 -1.268

•1064 genes whose expression level was changed by log base 2 or greater

•Analyze data

Future Directions

• Other hosts

• “Blue Sky” applications (Pathway related)

• Other HDAC inhibitors– Different effects for different methods of

deacetylation

• Drug Development

Acknowledgments

• NSF

• Fawcett Lab

– Jen Drake, Jen Feitweiss, Joe Bertsche, Nusara Satproedprai

• Barbour Lab

• Valerie Lab

– Beth Rosenburg

• Heilemann Lab

– Pat Bohdan

• Jeff, Sheryl, Jenn, and Billy

Presentation References

• References• 1. Baekelandt V., DeStrooper B., Nuttin B., Debyser Z. 2000. Gene therapeutic strategies for neurodegenerative

diseases. Current Opinion in Molecular Therapeutics 2:540-554. • 2. Bunnell B & Morgan RA. 1998. Gene therapy for infectious deceases. Clinical Microbiology Reviews 11:42-56. • 3. Decker T., Muller Mathias., Stockinger Silvia. 2005. The yin and yang of type I interferon activity in bacterial

infection. Nature Reviews Immunology 5:675-687. • 4. Isner, J.M. Myocardial gene therapy. 2002. Nature 415, 234-239.• 5. Marshall E. 1999. Clinical Trials- Gene therapy death prompts review of adenovirus vector. Science 286:2244-

2245.• 6. McCaffrey AP., Fawcett., Nakai H., McCaffrey L., Ehrhardt A., Pham T., Pandy K., Xu H., Feuss S., Storm T.,

Kay MA. 2008. The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Molecular Therapy 16(5):931-941.

• 7. Nusionzon I & Horvath CM. 2006. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Molecular and Cellular Biology 26(8):3106-3113.

• 8. Thomas CE., Ehrhardt A., Kay MA. 2003. Progress and problems with the use of viral vectors for gene therapy. Nature Reviews Genetics 4:346-358.

• 9. Tseng JF & Mulligan RC. 2002. Gene therapy for pancreatic cancer. Surgical Oncology Clinics of North America 11(3):537-569.

• 10. Wolkowicz R., Nolan GP. 2005. Gene therapy progress and prospects: Novel gene therapy approaches for AIDS. Gene Therapy 12: 467-476.

• 11. Nusinzon I., Horvath CM. 2005. Unexpected roles for deacetylation in interferon- and cytokine – induced transcription. Journal of Interferon and Cytokine Research 25:745-748.

• 12. Akira Shizuo. 2003. Toll-like Receptor Signaling. The Journal of Biological Chemistry 278(40):38015-38108.

Questions?