DIVISION OF ORTHOPAEDIC SURGERY

McGILL UNIVERSITY

Annual Report

For the period

July 1, 2009 to December 31, 2010

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EXECUTIVE SUMMARY

The McGill Division of Orthopaedics is based at the Montreal General Hospital, which houses one of Quebec’s busiest Level I Trauma Centres, a Supra-Regional Centre for Musculoskeletal (MSK) Oncology and serves the professional athletes of three world class sports teams. More than 200 beds dedicated to adult and paediatric orthopaedic care are distributed between the Montreal General, Montreal Children's, Shriners, Jewish General and St. Mary's hospitals.

In 2010, a core administrative staff coordinated the activities of 31 orthopaedic surgeons, 9 fellows and 36 residents with a support staff of 23 clinical and 12 research coordinators. The clinical and research activities in Arthroplasty, MSK Oncology, Paediatrics, Spine, Sports and Trauma are complemented by translational research in labs across the McGill campus that include the Joe Miller Lab (MGH), the JTN Wong Lab (740 Penfield), the Orthopaedic Research Labs (RVH, LDI) and the Shriners-MCH.

From 2009-2010 these laboratories trained 43 individuals in projects ranging from fundamental mechanisms of bone development to advanced technology for bone repair. In the same period, members of the Division held funding from peer reviewed sources including AO Foundation, CIHR, US Department of Defense, FRSQ, Leukemia & Lymphoma Society, NSERC, Orthopaedic Trauma Association and others and published more than 70 clinical and 50 basic scientific papers.

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SECTION 1: MEMBERS of the DIVISION of ORTHOPAEDIC SURGERY

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Farewell to our 2010 Senior Residents

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SECTION 2: HIGHLIGHTS from the DIVISION In November 2010, the McGill Medical Simulation Center hosted the 5th Annual McGill / Université de Montréal Arthroscopy Course. This one of a kind collaboration between Montreal’s two major academic institutions is an ever expanding 2-day course, organized by Dr. Mark Burman (MGH), Dr. Monika Volesky (JGH) and Dr. David Blanchette (UdeM). This unique collaborative effort is structured to offer arthroscopic training in a didactic and hands on manner to community orthopedic surgeons from across Quebec, the Maritimes and Eastern Ontario. The second day is dedicated to resident teaching, offered to Orthopaedic residents from all 4 Quebec medical teaching programs. Aside from a strong group of local McGill and U de M faculty, we welcomed representation from other Quebec teaching programs and were honored to have Dr. Freddie Fu as the special Invited Guest Faculty. Dr. Fu is the Chair of Orthopaedics at the University of Pittsburg and a world renowned leader in the field of Sports Medicine and Anterior Cruciate Ligament Reconstructive surgery. Dr. Fu shared his thoughts on Anatomic ACL reconstruction with course participants and residents during a much appreciated special Grand Rounds followed by a surgical cadaveric demonstration. Drs Burman, Volesky and Blanchette are already at work putting together the next course for November 2011. In October 2010, the Division hosted Mininder S. Kocher MD, Associate Professor of Orthopaedic Surgery, Harvard Medical School and Associate Director of the Division of Sports Medicine, Children's Hospital Boston as the 25th Annual Eugene Rogala Visiting Professor. Dr. Kocher is the head team physician for Babson College and the Boston Public School Sports Medicine Initiative and serves as physician for the Boston Ballet, the USA Figure Skating and Ski Teams, USA Track & Field and the Boston Marathon. He is the recipient of numerous awards for clinical excellence including the 2005 American Academy of Orthopaedic Surgeons (AAOS)/ OREF Kappa Delta Award/ Clinical Research Award, which is the highest research honour in orthopaedics. As the newly appointed Chief of Paediatric Orthopaedic Services for the Shriner’s Hospital for Children – Canada, Dr. Reggie Hamdy will provide leadership during the transition from the 85 year-old facility on Cedar Ave. to the Glen Campus facility, slated for completion in 2014. The Shriner’s revealed their plans for a new hospital at the Glen Campus adjacent to the Montreal Children’s Hospital (MCH) of the McGill University Health Centre (MUHC) in July 2010. The clinical facilities with four operating rooms, 22 single patient rooms and a rehabilitation facility will share services with the MCH and be supported by fundamental and translational research activities in 25,000 square feet of dedicated space. Dr. Jean Ouellet, appointed as Deputy Chief of Staff in December 2010, will work closely with Dr. Hamdy to ensure the timely and effective transition of clinical and research activities from the existing location on Cedar Ave. to the Glen Campus. The Division of Orthopaedic Surgery welcomes Dr. Neil Saran to the Montreal Children’s and Shriner’s Hospitals. Dr. Saran joined the Paediatric Orthopaedic Surgery team in September 2010 after completing fellowships in Paediatric Orthopaedics & Scoliosis at the Texas Scottish Rite Hospital for Children (Dallas, Texas) and Paediatric Spine & Hip Surgery at the BC Children’s Hospital (Vancouver, BC) and a concomitant MHSc in Clinical Epidemiology. In addition to his strong interest in Evidenced-Based Medicine, he has joined the expanding group of surgeon scientists in the Division. Dr Saran brings a multitude of much needed new skill sets to the McGill unit including hip realignment procedures such as the Ganz periacetabular osteotomy and surgical hip dislocations for adolescent and young adult patients with hip dysplasia or femoroacetabular impingement to prevent early onset osteoarthritis of the hip. In addition, he has a keen interest in minimally invasive spinal surgery to improve post-operative management and outcomes of patients undergoing spinal surgery. Congratulations to Dr. Saran on performing the first minimally invasive adolescent idiopathic scoliosis corrective surgery in Canada outside of British Columbia.

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SECTION 2A: HIGHLIGHTS of ACCOMPLISHMENTS from the SUB-SPECIALTIES

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SECTION 2B: HIGHLIGHTS of ACCOMPLISHMENTS from the LABORATORIES

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SECTION 3A: SUMMARY of CLINICAL RESEARCH ACTIVITIES Arthroplasty: The arthroplasty surgeons based at the MUHC-MGH and SMBD-JGH are conducting clinical research on the benefits of computer-assisted navigation in total knee arthroplasty and randomized trials on the long term outcome of metal-on-metal hip arthroplasty and plasma ion levels in these patients. Other work conducted in collaboration with colleagues across Canada and in Europe involves the evaluation of clinical outcomes including pain assessment in patients with novel hip implants and assessment of a new class of anticoagulants in patients undergoing surgical procedures. Oncology: The MUHC led the largest study ever conducted across Canada on outcomes following treatment of myxoid\round cell liposarcomas, as well as a study sponsored by the Public Health Agency of Canada and the Quebec Ministry of Health investigating the incidence and nature of post-transplant adverse events following allograft bone transplantation. The later study precedes the establishment of a national surveillance system of adverse events following tissue and organ transplantation. Collaboration continues with the University of Toronto and McMaster for banking sarcoma tissue and clinical data collection on a prospective study examining the benefits of surgery for long bone metastases. Paediatrics: The expanding group of physicians providing orthopaedic care at the Shriners and MCH sites are aligning their clinical research efforts in the surgical reconstruction of the hip, limbs and spine with fundamental work on cartilage and bone regeneration. Osteogenic proteins have been investigated to increase bone formation and botulinum toxin A to decrease pain in children undergoing limb lengthening to correct for discrepancies with the Ilizarov technique. Other work is investigating minimally invasive surgical approaches for the correction of hip dysplasia and novel growing rod implants for guided spine growth that will significantly improve the quality of life of young children with scoliosis. Spine: Much of the clinical research effort in spine effectively crosses the boundaries of that classified under Paediatrics and Trauma. The research efforts that fall in the adult spine domain include collaborative work with international consortia that addresses spinal stenosis and cord compression and the development of advanced instrumentation and technology for the management of fractures of the spine. Sports: In keeping with their role as attending physicians to some of Canada’s top sports teams and elite athletes, the research by MUHC surgeons is focused on the development of advanced 3D MRI for the planning of ACL reconstruction, the use of patient controlled analgesia following ACL reconstruction and the advantages of using different arthroscopic portals for minimally invasive procedures. Trauma: The orthopaedic trauma surgeons are involved in many ongoing studies with colleagues across Canada under the umbrella of the Canadian Orthopaedic Trauma Society (COTS). The MUHC group has played a leading role for more than a decade in prospective, randomized orthopaedic trials on a wide variety of topics including open reduction and internal fixation of fractures in the elderly, operative vs non-operative treatment of displaced calcaneal and clavicular fractures and closed reduction with external fixation. The COTS model for collaboration amongst surgeons and clinical research coordinators for the development of a research protocol is widely recognized as key to the success and productivity of the group.

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SECTION 3B: SUMMARY of TRANSLATIONAL RESEARCH ACTIVITIES

Joe Miller Lab: The main areas of research past and present include orthopaedic biomaterials and biomechanics, non-cemented implant fixation, porous materials, tissue response, bone remodeling response to total joint prostheses, drug delivery from implants for fixation enhancement, de-mineralized bone matrix for fixation enhancement, implant retrieval analysis, implant design, implant stiffness material testing (static and fatigue), stability measurements of knee and hip implants, hip simulator testing of bearing materials with emphasis on hard/hard bearings such as cobalt-chrome/cobalt-chrome and ceramic/ceramic and highly cross-linked polyethylene.

JTN Wong Lab: Current research is focused on skeletal regeneration and reconstruction using small animal models of implant infection and failure, fracture mal-union and repair, steroid-induced bone disease and genetic-based models of disorders of skeletal development and bone metabolism. The lab supports the research programs of clinician scientists from Trauma (Harvey, Henderson, Berry), Paediatrics (Ouellet, Saran) and Sports (Martineau) and from Haematology/Oncology (Seguin). Current trainees include one post PhD fellow, five post MD MSc or PhD candidates, two post BSc MSc candidates and five undergraduate students from high school, biotechnology and MDCM programs.

ORL-LDI: Efforts to characterize disc degeneration using gross morphology, current MR imaging, and biochemical techniques have been disappointing. Thus, one of the long term goals of our research activities is to develop an objective, accurate, non-invasive diagnostic tool (Quantitative MRI) in the detection and quantification of matrix biochemical composition and integrity and biomechanical changes in early disc degeneration. The inception of such a diagnostic tool will be a foundation for future work in diagnosing and treating spine pathology. A second area of research is focused on intervertebral disc regeneration using autologous mesenchymal stem cells embedded in a support scaffold.

ORL-RVH: The McGill Orthopaedic Research Laboratory was founded in May 1993. The Laboratory is a multidisciplinary research facility dedicated to basic and applied spinal research, focusing on the functional spinal unit, and the single motion segment of the spine. Fundamental and clinician scientists in the field of biomechanics, biochemistry, morphology, and electrophysiology, combine to form a fully integrated multidisciplinary laboratory. The group intends to provide a comprehensive understanding of spinal disorders that will lead to an improvement of current diagnostic and therapeutic tools of spinal pathology.

Shriners-MCH: Current research activities remain focused on the molecular basis and treatment of heritable disorders of the appendicular and axial skeleton including disorders of bone and mineral metabolism, limb length discrepancies, hip dysplasia and scoliosis. The work includes development of novel nanoparticle-based delivery systems for biological repair, cloning and characterization of components of the vitamin D signaling pathway, correlation of genotype-phenotype in non-lethal osteogenesis imperfect, molecular biochemical analysis of scoliotic intervertebral discs and the development of novel surgical implants and approaches for the correction of hip and limb length discrepancies and spine curvature.

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SECTION 4A: CLINICAL RESEARCH GRANTS by SUB-SPECIALTY

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SECTION 4A: (cont’d)

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SECTION 4B: TRANSLATIONAL RESEARCH GRANTS by LABORATORY

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SECTION 4B (cont’d)

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SECTION 4B (cont’d)

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SECTION 5A: CLINICAL RESEARCH PUBLICATIONS by SUB-SPECIALTY ARTHROPLASTY M. Bernstein, S.G. Bergeron, MD, J. Antoniou. Extensor Mechanism Deficiency in Total Knee Arthroplasty: Seminars in Arthroplasty 20: 190-93, 2009. S.G. Bergeron, N.M. Desy, V.S. Nikolaou, K. Debiparshad, J.Antoniou The Early Resutls of Metal-on-Metal Hip resurfacing: A prospective Study at Minimum Two-Year Follow-Up. NYU Bulletin. 2009; 67 (2): 132-135. B. Ma, S.G. Bergeron, H.J. Grant, J. Rudan, J. Antoniou. Quantifying Degree of Difficulty in Hip Resurfacing of Pistol-Grip Deformity: NYU Bulletin 2009; 67 (2): 154-158. V.S. Nikolaou, S.G. Bergeron, O.L. Huk, D.J. Zukor, J. Antoniou. Evaluation of Persistent Pain after Hip Resurfacing: NYU Bulletin 2009; 67 (2): 168-72. S.G. Bergeron, K.J. Kardash, O.L. Huk, D.J. Zukor, J. Antoniou. The functional outcome after a single perioperative dose of dexamethasone in total hip arthroplasty: Clin Orthop Relat Res. 2009 Jun;467(6):1458-62. S.G. Bergeron, K.J. Kardash, O.L. Huk, D.J. Zukor, J. Antoniou. Perioperative Dexamethasone Does Not Affect Functional Outcome in Total Hip Arthroplasty. Clin Orthop Relat Res. 2009 Jun;467(6):1463-7. Turpie A.G.G., Bauer K.A., Davidson B.L., Fisher W.D., Gent M., Huo M.H., Sinha U Gretler D.D A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for the prevention of thromboembolic events after total knee replacement Journal of Thrombosis and Haemostasis, Vol. 101, 68-76, 2009. Turpie A.G.G., Lassen M.R.., Davidson B.L., Bauer K.A., Gent M., Kwong L.M. Cushner F.D., Lotke P.A., berkowitz S.D., bandel T.J., Benson A., Misselwitz F., Fisher W.D., Huo M.H., Sinha U. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD 4): a randomized trial Lancet, Vol. 373,1673-80. Gdalevitch M., Smith K and Tanzer M: Radiographic Determination of Acetabular Cartilage Delamination in Patients with Labral Tears. Clin Orthop Relat Res, 2009 467:985–99. Sullivan, M.J.L., Tanzer, M., Stanish,W.D., Fallaha, M., Keefe, F.J., Simmonds, M., Dunbar, M.: Psychological Determinants of Problematic Outcomes Following Total Knee Arthroplasty. Pain, 2009 143:123129. J Antoniou Hip Resurfacing Was Not Better Than Total Hip Arthroplasty for Hip Disease J Bone Joint Surg Am. 2010 Nov;92(16):2734. VS Nikolaou, SG Bergeron, N.M. Desy, J. Antoniou Total Knee Replacement and Chemical Thromboprophylaxis: Current Evidence Curr Vasc Pharmacol. 2010. NM Desy, SG Bergeron, A Petit, OL Huk, J Antoniou. The influence of surgical variables on metal ion levels after hip resurfacing Clin Orthop Relat Res. 2010. M Bernstein, AJ Walsh, A Petit, DJ Zukor, J Antoniou. Femoral Head Size Does Not Affect Ion Values in Metal-on-Metal Total Hips Clin Orthop Relat Res. 2010. I. Livshetz, Y.S. Brin, C. Holcroft, J. Antoniou, D.J. Zukor. Deviations between intra-operative navigation data and post-operative weight-bearing x-rays Comput Aided Surg. 2010;15(1-3):56-62. Y.S. Brin, V.S. Nikolaou, L. Joseph, D.J. Zukor, J. Antoniou. Imageless computer assisted versus conventional total knee replacement. A Bayesian meta-analysis of 23 comparative studies Int Orthop. 2010.

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J. Antoniou, S.G. Bergeron, B. Ma, R. Chakravertty, J. Rudan. The Effect of the Cam Deformity on the Insertion of the Femoral Component in Hip Resurfacing J Arthroplasty 2010. Y.S. Brin, I. Livshetz, J. Antoniou, S. Greenberg-Dotan, D.J. Zukor. Precise landmarking in computer assisted total knee arthroplasty is critical to final alignment. J Orthop Res. 2010 Oct;28(10):1355-9. V. Nikolaou, J. Antoniou Revision Total Hip Arthroplasty In Practical Procedures of Elective Orthopaedic Surgery:A trainee's companion, 2010. A Walsh, V. Nikolaou, J. Antoniou Revision of the Acetabular Components: What is the Role of Structural Bulk Allografts and Porous Titanium Implants? Evidence-Based Orthopaedics, BMJ Publishing, 2010. M. Bernstein, S. Bergeron, V. Nikolaou, J. Antoniou Painful Total Hip Arthroplasty: Pain Without Apparent Cause. Error! Hyperlink reference not valid. Schulman S., Angeras U., bergzuist D., Eriksson B., Lassen M.R., Fisher W.D. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients Journal of Thrombosis and Haemostasis, Vol. 8, 202-2004, 2010. Weitz J.I., Cao C., Ericksson B.I., Fisher W.D., Kupfer S., Raskob g., Spaeder J., Turpie A.G.G. A dose-finding study with TAK-442, an oral factor Xa inhibitor, in patients undergoing elective total knee replacement surgery Thromb Haemost, Vol 101, 1150-1157, 2010. Garbuz, D., Tanzer, M., Greidanus, N.V., Masri, B.A., Duncan, C.P.: Metal on Metal Hip Resurfacing vs Large Diameter Hip Arthroplasty: A Randomized Clinical Trial. Clin Orthop Relat Res. 2010. Feb;468(2):318-25. Hemmerling, T.M, Minardi, C., Bevilacqua, L., Zaouter, C., Sinha, A., Tanzer, M.: Continuous Block of the Articular Branches of the Femoral Nerve as a Novel Technique for Pain Control after Hip Arthroplasty. International Journal of Ultrasound and Applied Technologies in Perioperative Care, January-April 2010;1(1):13-17. Carli, F, Clemente, A., Asenjo, J.F., Kim, D.J., Mistraletti, G., Gomarasca, M., Morabito, A Tanzer, M.: Analgesia and Functional Outcome after Total Knee Arthroplasty: periarticular infiltration vs continuous femoral nerve block. Br J Anesthesia 2010 Aug;105(2):185-95.

ONCOLOGY Turcotte RE, Ferrone M, Isler MH, Wong C, Soft tissue sarcoma of the popliteal fossea. Can J Surg, 2009 Feb;52(1):51-55. Al Ghamdi A, Hings I, Turcotte RE, The management of bone metastases; A surgical perspective Aging Health, June 2009, Vol. 5, No. 3, Pages 313-321. Karam I., Devic S., Hickeson M., Roberge D., Turcotte RE, Freeman CR. PET/CT for Radiotherapy Treatment Planning in Patients with Soft Tissue Sarcomas. Int J Radiat Oncol Biol Phys. 2009; 75(3): 817–821. Davidge K, Bell RS, Ferguson P, Turcotte RE, Wunder J, Davis A.M. Patient Expectations for Surgical Outcome in Extremity Soft Tissue Sarcoma J Surg Oncol.2009;100:375-381. Charest M, Hickeson M, Lisbona R, Novales JA, Derbekyan V, Turcotte RE. FDG PET-CT imaging in primary osseous and soft tissue sarcomas – A retrospective review of 212 cases Eur J Nucl Med Mol Imaging 2009; 36(12):1944-51. Rabinovich A, Mak IWY, Cowan RW, Turcotte RE, Colterjohn N, Singh G, Ghert M. Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone. The Open Bone Journal, 2009:1, 46-52.

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Mak I. Seidlitz EP. Cowan RW. Turcotte RE. Popovic S. Wu WCH. Singh G. Ghert M. Hum Evidence for the Role of MMP-13 in Bone Resorption by Giant Cell Tumour of Bone Pathol 2010 Sep;41(9):1320-9. H Algawahmed, R Turcotte, F Farrokhyar, M Ghert. High-speed burring with and without the use of chemical or thermal adjuvants in the intralesional management of Giant Cell Tumor of Bone: A systematic review and meta-analysis Sarcoma Epub Jul 27 2010. A Ajlan, T Alcindor, R Turcotte, A Nahal. Dedifferentiated giant cell tumor of bone in the form of low grade fibroblastic osteogenic sarcoma Curr Oncol 2010 Aug;17(4):71-6. Abatzoglou S, Turcotte RE, Adoubali A, Isler MH, Roberge D. Local Recurrence After Initial Multidisciplinary Management of Soft Tissue Sarcoma: Is There a Way Out? Clin Orthop Relat Res. 2010 Nov;468(11):3012-8. D Latt, RE Turcotte, MH Isler, C Wong Soft tissue sarcoma of the foot Can J Surg. 2010 Dec;53(6):424-31. Gortzak, R. Kandel, B. Deheshi, J. Werier, R. E. Turcotte, P. C. Ferguson, and J. S. Wunder. The efficacy of chemical adjuvants on giant-cell tumour of bone: An in vitro study. J Bone Joint Surg Br 2010 92-B: 1475-9. Saran N, Turcotte RE, Zhang R. Osteogenic Protein-1 Delivered by Hydroxyapatite-coated Implants Improves Bone Ingrowth in Extracortical Bone Bridging Clin Orthop Relat Res. 2010 Sep 28. [Epub ahead of print]. S. Singh, I Mak, P. Power, M. Cunnigham, R Turcotte, M Ghert Gene transfection in primary stem-like cells of Giant Cell Tumor of Bone; A Short Report. (Accepted Stem Cell and Cloning: Advances and Applications Sept 2010). Roberge D, Skamene T, Nahal A, Turcotte RE, Powell T, Freeman C. Radiol ogical and Pathological Response Following Pre-operative Radiotherapy for Soft-tissue Sarcoma. Radiother Oncol. 2010 Oct 30. [Epub ahead of print]. Farrokhyar F, Hickey M, Deheshi B, Turcotte RE, Ghert M. A systematic review and meta-analysis of intralesional vs. wide resection for low-grade intramedullary chondrosarcoma (accepted ASO Nov 2010 ASO-2010-09-1569.R1).

PAEDIATRICS Dohin, B., Dahan, N., Fassier, F., Hamdy, R.C.: The use of OP-1 (Osteogenic Protein 1) in Children : Safety and Efficacy. Clinical Orthopaedics and Related Research In Press 2009. Hamdy RC, Montpetit K, Raney EM, Aiona MD, Fillman RR, MacKenzie W, McCarthy J, Chafetz R, Sienko Thomas SE, Tamayo C, Littleton AJ, Ruck-Gibis J, Takahashi S, Rinaldi M, Finley AG, Platt RW, Dahan-Oliel N: Botulinum Toxin A Injection in alleviating pain and Improving functional outcome in children undergoing limb lengthening and deformity correction. Results of a Pilot Study Journal of Paediatric Orthopaedics: In Press 2009. Rauch F. Munns CF. Land C. Cheung M. Glorieux FH Risedronate in the treatment of mild pediatric osteogenesis imperfecta: a randomized placebo-controlled study. Journal of Bone & Mineral Research 24(7):1282-9, 2009. Fratzl-Zelman N. Roschger P. Misof BM. Pfeffer S. Glorieux FH Klaushofer K. Rauch F. Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults Bone 44(6):1043-8, 2009. Montpetit K, Hamdy RC, Dahan N, Measurement of Health Related Quality of Life in Children Undergoing External FixatorTreatment for Lower Limb Deformities. Journal of Paediatric Orthopaedics Dec;29(8):920-6. 2010. Ward LM. Rauch F. Whyte MP. D'Astous J. Gates PE. Grogan D. Lester EL. McCall RE. Pressly TA Sanders JO Smith PA. Steiner RD. Sullivan E. Tyerman G. Smith-Wright DL. Verbruggen N. Heyden N. Lombardi A. Glorieux

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FH. Alendronate for the treatment of pediatric osteogenesis imperfecta: a randomized placebo-controlled study. Journal of Clinical Endocrinology & Metabolism 96(2):355-64, 2010. Saran N. Rathjen KE Guided Growth for Pediatric Lower Limb Angular Deformity Correction Journal of the American Academy of Orthopaedic Surgeons. 2010 Sep;19(9):528-36.

SPINE Bassi M, Jarzem PF, Steibel M, Barriga P, Ouellet J, Reindl R , An in vitro study on the effects of freezing, spine segment, repeat measurement, and individual cord properties on cord interstitial pressure. Spine. 2009 Feb 15;34(4):351-5. Jean A. Ouellet, MD, Loren Geller, Willem S. Strydom, Mary Rabzel, Rudolf Reindl, Peter Jarzem, and Vincent Arlet, Pressure Mapping as an Outcome Measure for Spinal Surgery in Patients With Myelomeningocele, SPINE, 34, (24), 2679 –2685, 2009. Arlet V, Ouellet JA, Shilt J, Shen FH, Wood K, Chan D, Hicks J, Bersusky E, Reddi V Subjective evaluation of treatment outcomes of instrumentation with pedicle screws or hybrid constructs in Lenke Type 1 and 2 adolescent idiopathic scoliosis. What happens when judges are blinded to the instrumentation? Eur Spine J. 2009 Dec;18(12):1927-35. Epub 2009. Mélanie Gaudreault, Sylvain L’Espérance, Maria Li, Jean-Albert Ouellet, Axel Tosikyan, François Vincent; Québec Provincial Practice Guideline for Metastatic spinal cord compression, Comité de l’évolution des pratiques en oncologie, www.msss.gouv.qc.ca/cancer. 2010.

SPORTS Halloran JP, Martineau PA. Knee Dislocation Timing of Management Canadian Orthopaedic Association Bulletin, 2009, Issue 85. Trumble TE, Martineau PA In Reply re: Volar plating of AO C3 distal radius fractures: biomechanical evaluation of locking screw and locking smooth peg Journal of Hand Surgery, 2009 Feb; 34(2):365. Martineau PA, Malone KJ, Hanel DP. Bridge Plating of Distal Radius Fractures: Fractures and Injuries of the Distal Radius and Carpus The Cutting Edge, Eds. Slutsky and Osterman, Saunders, Philadelphia, PA; 2009, Chapter 19:201-208. Martineau PA, Fening SD, Miniaci A. Anterior Opening Wedge High Tibial Osteotomy: the Effect of Increasing Tibial Slope on the Biomechanics of the Knee. Canadian Journal of Surgery, 2010, 53(4):261-267. Martineau PA, Malone KJ, Hanel DP. Bridge Plating of Distal Radius Fractures: Operative Techniques in Orthopedic Surgery Eds. Wiesel, Hunt, Lippincott Williams & Wilkins, Philadelphia, PA; 2010, Part 6, Chapter 13:2218-2223. Melchior JA, Burton RI, Martineau PA, Trumble TE Tendon Transfers Plastic Surgery Secrets Plus, 2nd edition Hanley & Belfus, Elsevier, St-Louis, MO; 2010, Chapter 127 825-837.

TRAUMA Desy NM, Bergeron SG, Berry GK, Reindl R., Harvey EJ Intramedullary Nails in the Treatment of Extracapsular Hip Fractures Minerva Ortopedica e Traumatologica 60(6):515-26, 2009. L Geller, M Bernstein, A Carli, GK Berry, R Reindl, EJ Harvey Efficacy of different fixation devices in maintaining an initial reduction for surgically managed distal radius fractures Can J Surg. 2009; 52 (5): E161-6.

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L. Geller, M. Bernstein, A. Carli, GK Berry, R. Reindl, EJ Harvey Efficacy of different fixation devices in maintaining an initial reduction for surgically managed distal radius fractures Can J Surgery 2009;52(5): E161.6. Harvey EJ Nailing Metaphyseal Fractures of the Tibia: American Academy of Orthopaedic Surgeons Web site: Orthopaedic Knowledge Online 2009;7(9). Harvey EJ. A time for change Canadian Journal of Surgery 2009 Jun; 52(3):173-174. Harvey, E.J. Canadian healthcare is not universal Canadian Journal of Surgery. 2009 52(5):372-3. Harvey EJ. H1N1 and the surgeon Canadian Journal of Surgery 2009 52(5):372-3. Talbot M, Tien HC.The use of recombinant factor VIIa in trauma patients. J Am Acad Orthop Surg. 2009 Aug;17(8):477-81. Cole PA, Talbot M, Schroder LK, Anavian J Abstract:Extra-articular Malunions of the Scapula: A Comparison of Functional Outcome Before and After Reconstruction J Bone Joint Surg 2009 Rahme, E., Kahn, SR, Dasgupta, K., Burman, M., Bernatsky, S., Habel, Y.,Berry, G.: Short term mortality associated with failure to receive continued care following discharge from a hospitalization for hemi- arthroplasty: A retrospective cohort study CMAJ 2010;182: 1421-1426. N. Saran, S.G. Bergeron, B. Benoit, R. Reindl, E.J. Harvey, G.K. Berry Risk of axillary nerve injury during percutaneous proximal humerus locking plate insertion using an external aiming guide Injury, Int. J. Care Injured 2010; 41:1037-1040- Martineau PA, Berry GK, Harvey EJ Plating For Distal Radius Fractures Hand Clin. 2010 Feb; 26(1): 61-9. Guy P, Al-Otaibi M, Harvey EJ, Helmy N The ‘Safe Zone’ for Extra-Articular Screw Placement During Acetabular Surgery J Orthop Trauma. 2010 May; 24 (5):279-83. Theodoropoulos JS, Andreisek G, Harvey EJ, Wolin P Magnetic resonance imaging and magnetic resonance arthrography of the shoulder: dependence on the level of training of the performing radiologist for diagnostic accuracy.Skeletal Radiol. 2010; 39 (7): 661-7. Pape HC, Marcucio R, Humphrey C, Colnot C, Knobe M, Harvey EJ. Trauma-induced inflammation and fracture healing: J Orthop Trauma. 2010 Sep;24(9):522-5. Agel J, Harvey EJ. A 7-year review of men's and women's ice hockey injuries in the NCAA: Can J Surg. 2010 Oct;53(5):319-23. EJ Harvey, M Sen, LS Levin Free Tissue Complications In Fracture Management In Complications in Orthopaedics: Open Fractures AAOS Monograph Series 2010. M Lee and EJ Harvey Proximal Femur Fractures OKU 4 Orthopedic Trauma 2010. Harvey EJ. Canadian researchers performing world-class research Can J Surg. 2010 Feb; 53(1): 4-5. CMANews Feb 2010 : http://www.cma.ca/index.cfm/ci_id/90081/la_id/1.htm. Harvey EJ. Why is my room always late? Canadian Journal of Surgery 2010. Harvey EJ. How many hours should a surgical resident work? Canadian Journal of Surgery 2010 Oct;53(5):292-3.

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SECTION 5B: TRANSLATIONAL RESEARCH PUBLICATIONS by LABORATORY

JOE MILLER LAB Bobyn JD, Tanzer M, McKenzie K, Karabasz D, Krygier JJ. Locally delivered bisphosphonate for enhancement of bone formation and implant fixation J Bone Joint Surg (Am) 91 Suppl 6:23-3, 2009. McKenzie K, Bobyn JD, Roberts J, Karabasz D, Tanzer M. Bisphosphonate Remains Highly Localized After Elution From Porous Implants. Clin Orthop Rel Res, e-publication, Aug 31 2010. Lim L, Bobyn JD, Bobyn KM, Lefebvre L-P, Tanzer M. Demineralized bone matrix around porous implants promotes rapid gap healing and bone ingrowth. Clin Orthop Rel Res, In press 2011. Bobyn JD. Next generation porous metals for biologic fixation In: Orthopaedic Knowledge Update 4 – Hip and Knee Reconstruction (Glassman AH, Tanzer M, Lachiewicz P, eds) Amer Acad Orthop Surg, Rosemont IL, In press 2011.

JTN WONG LAB Duque, D. Rivas, W. Li, A. Li, J.E. Henderson, G. Ferland and P. Gaudreau Age-related bone loss in the LOU/c rat model of healthy ageing Exp Gerontology Exp Gerontology 44, 183-189,2009. S Ibasco, F Tamimi, R Meszaros, DL Nihouannen, S Vengallatore, EJ Harvey, JE Barralet Magnesium-sputtered titanium for the formation of bioactive coatings Acta Biomaterialia Jul; 5 (6): 2338-47, 2009. Kerachian MA, Cournoyer D, Harvey EJ, Chow TY, Neagoe PE, Sirois MG, Séguin C. Effect of High Dose Dexamethasone on Endothelial Haemostatic Gene Expression and Neutrophil Adhesion J Steroid Biochem Mol Biol. Sep; 116 (3-5): 127-33, 2009. B Ge, D K Pokholok, J Le, E Grundberg, L Morcos, DJ Verlaan, AK Naumova, T Kwan, V Koka, KCL Lam, J Dias, R Hoberman, A Montpetit, MM Joly, EJ Harvey, D Sinnett, P Beaulieu, R Hamon et al Global patterns of cis-variation in human cells revealed by high-density allelic expression analysis Nature Genetics Nov; 41 (11): 1216-22, 2009. D. Rivas, W. Li, R. Akter, J.E. Henderson, G. Duque Accelerated features of age-related bone loss in Zmpste24 metalloproteinase-deficient mice J Gerentology A 64, 1015-1024, 2010. E.J. Harvey, J.E. Henderson and S.T Vengallatore Nanotechnology and Bone Healing (Invited Review) J Orthop Trauma 24 S25-30, 2010. V. Serpooshan, M Julien, O Nguyen, H Wang, A Li, N Muja, J.E. Henderson and S.N. Nazhat Reduced hydraulic permeability of three dimensional collagen scaffolds attenuates gel contraction and promotes the growth and differentiation of mesenchymal stem cells. Acta Biomaterialia 6 3978-3987, 2010. M. Li, Y. Seki, P.H.L. Freitas, M. Nagata, T. Kojima, S. Sultana, S. Ubaidus, T. Maeda, J. Shimomura-Kuroki, J.E. Henderson, M. Tamura, K. Oda, R. Takagi and N. Amizuka. FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line J Electron Microscopy 59, 227-236, 2010. M. Hajj-Hassan, M. Khayyat-Kholgi, H Wang, V. Chodavarapu and J.E. Henderson Response of bone marrow derived mesenchymal stromal cells to dry-etched porous silicon scaffolds. J Biomed Mat Res (A) In Press 2010. N. Ochotny, A.M. Flenniken, C. Owen, I. Voronov, R.A. Zirngibl, L.R. Osborne, J.E. Henderson, S.L. Adamson, J. Rossant, M.F. Manolson and J.E. Aubin 2011 The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice. J Bone Miner Res In Press 2010.

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Henderson J.E, C.Gao, E.J. Harvey Chapter 2/16 Methods in Bone biology: tissue isolation and manipulation In: Osteoporosis Research: Animal models Editors. G, Duque, K Watanabe Springer UK (Submitted to Editor) 2010. MA Kerachian, D Cournoyer, EJ Harvey, TY Chow, LR Bégin, A Nahal, C Séguin New Insights in the Pathogenesis of Glucocorticoid-Induced Avascular Necrosis: Microarray Analysis of Gene Expression in a Rat Model. Arthritis Research & Therapy, Jun 25;12(3):R124. 2010.

ORL-LDI Girard-Lauriault PL. Truica-Marasescu F. Petit A. Wang HT. Desjardins P. Antoniou J. Mwale F. Wertheimer MR. Adhesion of human U937 monocytes to nitrogen-rich organic thin films: novel insights into the mechanism of cellular adhesion. Macromolecular Bioscience 9(9):911-21, 2009. Mwale F. Yao G. Ouellet JA. Petit A. Antoniou J. Effect of parathyroid hormone on type X and type II collagen expression in mesenchymal stem cells from osteoarthritic patients. Tissue engineering Part A.. 16(11):3449-55, 2010. Petit A. Wang HT. Girard-Lauriault PL. Wertheimer MR. Antoniou J. Mwale F. Novel insights into the mechanism of decreased expression of type X collagen in human mesenchymal stem cells from patients with osteoarthritis cultured on nitrogen-rich plasma polymers: implication of cyclooxygenase-1. Journal of Biomedical Materials Research Part A. 94(3):744-50, 2010. Tkaczyk C. Huk OL. Mwale F. Antoniou J. Zukor DJ. Petit A. Tabrizian M Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells Journal of Biomedical Materials Research Part A. 94(2):419-25, 2010. Tkaczyk C. Huk OL. Mwale F. Antoniou J. Zukor DJ. Petit A. Tabrizian M. Investigation of the binding of Cr(III) complexes to bovine and human serum proteins: a proteomic approach. Journal of Biomedical Materials Research Part A. 94(1):214-22, 2010.

ORL-RVH Tillgren V, Önnerfjord P, Haglund L and Heinegård D The tyrosine sulfate rich domains of the LRR-proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin binding proteins including bioactive factors. J. Biol. Chem. Oct 16;284(42):28543-53, 2009. Haglund L, Ouellet J, and Roughley P Variation in chondroadherin abundance and fragmentation in the human scoliotic disc Spine Jun 15;34(14):1513-8, 2009. Jim B, Steffen T, Moir J, Roughley P and Haglund L. Development of a novel intervertebral disc organ culture system to study degeneration and repair potential Eur Spine J. Feb 19. [Epub ahead of print] 2011. Haglund L, Tillgren V, Addis L, Wenglen C, Recklies A. D, and Heinegård D. Identification and characterization of the integrin α2β1 binding motif in Chondroadherin mediating cell attachment J. Biol. Chem, Feb 4;286(5):3925-34, e-print Dec 2010, 2010. Gawri, R, Mwale, F, Ouellet, J, Roughley, P, Steffen, T, Antoniou, J, Haglund, L. Development of an organ culture system for long term survival of the intact human intervertebral disc Spine Jan 25. [Epub ahead of print] 2011.

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SHRINERS-MCH Yu, V.W.C., O. Akhouayri, and R. St-Arnaud FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes. Gene Expression Patterns 9: 335-340, 2009. Naja, R.P., O Dardenne, A. Arabian, and R. St-Arnaud Chondrocyte-specific modulation of cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development. Endocrinology 150: 4024-4032, 2009. Alam, N., R. St-Arnaud, D. Lauzier, V. Rosen, and R.C. Hamdy Are endogenous BMPs necessary for bone healing during distraction osteogenesis Clin Orthop Relat Res 467: 3190-3198, 2009. Wuertz K. Godburn K. MacLean JJ. Barbir A. Donnelly JS. Roughley PJ. Alini M. Iatridis JC. In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression Journal of Orthopaedic Research 27(9):1235-42, 2009. Cecil DL. Appleton CT. Polewski MD. Mort JS Schmidt AM. Bendele A. Beier F. Terkeltaub R. The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. Journal of Immunology 182(8):5024-31, 2009. Wilson S. Hashamiyan S. Clarke L. Saftig P. Mort J. Dejica VM Bromme D Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities. American Journal of Pathology 175(5):2053-62, 2009. Lee ER. Lamplugh L. Kluczyk B. Leblond CP. Mort JS Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development. Developmental Dynamics 238(6):1547-63, 2009. Edouard T. Alos N. Chabot G. Roughley P. Glorieux FH. Rauch F. Short- and long-term outcome of patients with pseudo-vitamin D deficiency rickets treated with calcitriol. Journal of Clinical Endocrinology & Metabolism 96(1):82-9, 2011. Rauch F. Lalic L. Roughley P. Glorieux FH. Genotype-phenotype correlations in nonlethal osteogenesis imperfecta caused by mutations in the helical domain of collagen type I. European Journal of Human Genetics. 18(6):642-7, 2010. Fratzl-Zelman N. Morello R. Lee B. Rauch F Glorieux FH Misof BM. Klaushofer K. Roschger P. CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with osteogenesis imperfecta type VII. Bone 46(3):820-6, 2010. St-Arnaud, R.,and V. Mandic. FIAT control of osteoblast activity J Cell Biochem 109: 453-459, 10. Meury, T., O. Akhouayri, T. Jafarov, V. Mandic, and R. St-Arnaud Nuclear αNAC influences bone matrix mineralization and osteoblast maturation in vivo. Mol Cell Biol 30: 43, 2010. Lou, Y-R., F. Molnár, M. Peräkylä, S. Qiao, A.V. Kalueff, R. St-Arnaud, C. Carlberg, and P. Tuohimaa. 25-hydroxyvitamin D3 is an agonistic vitamin D receptor ligand. J Steroid Biochem Mol Biol 118: 162-170, 2010. Pontier, S.M., L. Huck, D.E. White, J. Rayment, V. Sanguin-Gendreau, B. Hennessy, D. Zuo, R. St-Arnaud, G.B. Mills, S. Dedhar, C.J. Marshall, and W.J. Muller. Integrin-Linked Kinase plays a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Oncogene 29: 3374-3385. 2010. Dossa, T., A. Arabian, J.J. Windle, S. Dedhar, S.L. Teitelbaum, F.P. Ross, G.D. Roodman, and

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R. St-Arnaud. Osteoclast-specific inactivation of the Integrin-Linked Kinase (ILK) inhibits bone resorption. J Cell Biochem 110: 960-967. 2010. St-Arnaud, R., V. Mandic, and B. ElChaarani. FIAT, the Factor Inhibiting ATF4-mediated Transcription, also represses the transcriptional activity of the bZIP factor FRA-1. Ann. NY Acad. Sci. 1192: 338-343. 2010. St-Arnaud, R. Critical mass (close to the bone) International Innovation, June 2010 issue:100-102, 2010. St-Arnaud, R. Cyp24a1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24. J Steroid Biochem Mol Biol 121: 254-256, 2010. De Croos JN. Roughley PJ. Kandel RA. Improved bioengineered cartilage tissue formation following cyclic compression is dependent on upregulation of MT1-MMP. Journal of Orthopaedic Research 28(7):921-7, 2010. Jones KB. Piombo V Searby C Kurriger G. Yang B. Grabellus F. Roughley PJ, Morcuende JA Buckwalter JA Capecchi MR. Vortkamp A. Sheffield VC A mouse model of osteochondromagenesi s from clonal inactivation of Ext1 in chondrocytes Proceedings of the National Academy of Sciences of the United States of America 107(5):2054-9, 2010. Naudin C. Lecaille F. Chowdhury S. Krupa JC. Purisima E. Mort JS. Lalmanach G The occluding loop of cathepsin B prevents its effective inhibition by human kininogens. Journal of Molecular Biology 400(5):1022-35, 2010. Appleton CT. Usmani SE. Mort JS Beier F. Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation. Laboratory Investigation 90(1):20-30, 2010.