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Did you know thatelephants are one of thefew animals that canrecognize themselves ina mirror? And that...
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This annual international research prize recognizes
accomplishments in neurobiology research based on
methods of molecular and cell biology. The winner and
finalists are selected by a committee of independent
scientists, chaired by the Editor-in-Chief of Science.
Past winners include postdoctoral scholars and
assistant professors.
To be eligible, you must be 35 years of age or younger.
If you´re selected as this year´s winner, you will receive
$25,000, have your work published in the prestigious
journal Science and be invited to visit Eppendorf in
Hamburg, Germany.
Deadline for entries
June 15, 2008
2007 Winner
Rachel Wilson, Ph.D.
Assistant Professor
of Neurobiology
Harvard Medical School
Eppendorf & Science Prize for
Neurobiology
For more information
www.eppendorf.com/prize
Get recognized!
$25,000
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GE Healthcare Bio-Sciences AB, a General Electric Company.
Björkgatan 30, 751 84 Uppsala, Sweden
© 2008 General Electric Company – All rights reserved.
GE31-07
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© Copyright 2007 Thomson. EndNote is a registered trademark of Thomson. All trademarks are the property of their respective companies.
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Anyone who has ever written a paper knows all too wellthe steps required for it to become a success. That’s whereEndNote® comes to the rescue. EndNote is there as youstart your research and collect references.And, it continuesto support you as you cite references in your paper.By listening to writers and researchers like you, anddelivering ways to simplify your work, EndNote remainsthe favored, time-saving solution for organizing referencesand creating instant bibliographies. The newest release,EndNote X1, allows you to create custom groups of
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The GairdnerFoundationannounces the2008 GairdnerInternationalAwardees.
The Gairdner Foundation is pleased to
announce the winners of the 2008 Gairdner
International Awards. They will be presented at
a gala banquet in Toronto on October 23, 2008.
The Gairdners were founded 49 years ago by
the late Toronto businessman, James Gairdner,
and today rank among the most prestigious
awards in science. Some 70 of 288 Gairdner
awardees have gone on to win the Nobel Prize.
The closing date for nominations for the
2009 Canada Gairdner International Awards is
October 1, 2008. For more information on the
Gairdner Foundation and its national program
of events, log on to www.gairdner.org.
In association with:
Professor Harald zur Hausen, DSc., MDProfessor Emeritus and recent Chairman and
Scientific Director, German Cancer Research
Centre, Heidelberg, Germany
“for his discovery of the causative role of
papillomaviruses in cancer of the cervix
which led to the development of a successful
HPV vaccine.”
Dr. Victor Ambros, PhDProfessor, Department of Molecular Medicine,
University of Massachusetts Medical School,
MA, USA
“for their discovery of microRNA’s and
their mechanism of gene regulation.”
Dr. Gary Ruvkun, PhDProfessor of Genetics, Harvard Medical
School, Boston, MA, USA
Dr. Nahum Sonenberg, PhDProfessor, Department of Biochemistry and
McGill Cancer Centre, McGill University,
Montreal, QC, Canada
“for his discovery of mechanisms controlling
gene expression in human cells at the level
of protein synthesis.”
Dr. Samuel Weiss, PhDProfessor of Cell Biology and Anatomy and
Pharmacology and Therapeutics, University
of Calgary, Calgary, AB, Canada
“for his seminal discovery of adult neural
stem cells in the mammalian brain and
it’s importance in nerve cell regeneration.”
Dr. Allan Bernstein, OC, PhDExecutive Director, Global HIV Vaccine
Enterprise, New York, USA
“for his outstanding contribution to Canadian
health research as a scientist, research institute
director and as the inaugural President of the
Canadian Institutes of Health Research.”
2008 Gairdner Wightman Award
for outstanding leadership in
Canadian medicine
Finnzymes’ novel PCR enzyme outperforms every Taq-based hot start
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were run on a 1 % agarose gel. Total cycling times indicated at bottom.
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Established and presented by:
Established in 1995, the GE & Science Prize for Young Life Scientists
brings science to life by recognizing outstanding Ph.D.s from
around the world and rewarding their research in the field of
molecular biology.
This is your chance to gain international acclaim and recognition
for yourself and your faculty, and to turn your scientific ideas
into reality.
• If you were awarded your Ph.D. in molecular biology* during
2007, describe your work in a 1000-word essay.
• Submit your essay for the 2008 GE & Science Prize for Young
Life Scientists.
• A panel of distinguished scientists will select one Grand Prize
winner and four regional winners.
• Submission deadline August 1.
Few awards in science are more rewarding than the Science/AAAS
and GE Healthcare-sponsored prize – just ask the Grand Prize
winner for 2007. In addition to having his essay published in
Science, Matthew Stremlau received $25,000, was flown to the
awards ceremony in Stockholm, Sweden, and got to pick the
brains of Nobel laureates Mario R. Capecchi, Sir Martin J. Evans
and Oliver Smithies.**
GE & Science Prize for Young Life Scientists:
Ph.D. Research Re-imagined.
For more information, go to
www.gelifesciences.com/science
Get published in Science, meetthe Nobel laureates, win a tripto Stockholm and $25,000.
* For the purpose of this prize, molecular biology is defined as “that partof biology which attempts to interpret biological events in terms of thephysico-chemical properties of molecules in a cell” (McGraw-Hill Dictionaryof Scientific and Technical Terms, 4th Edition).
**Nobel Prize 2007 winners in Physiology or Medicine for their discoveriesof principles for introducing specific gene modifications in mice by theuse of embryonic stem cells.
Grand Prize winner Matthew Stremlau presents his
research to a captivated audience
Prize winners with Nobel laureates Mario R. Capecchi,
Sir Martin J. Evans and Oliver Smithies.
Submission deadline
August 1
Proteinmodification by ubiquitin or the ubiquitin-like proteinshas been implicated in a variety of cellular processes includingproteosomal degradation, cell signaling, gene transcription, DNArepair, and protein localization. The nature, location, and extentof these posttranslational modifications appear to influence theircellular fate. Recent evidence that small molecule inhibitors ofthe proteasome can be used in the treatment of human cancershas launched intensive efforts to discover new drugs that willselectively inhibit the activities of disease-specific components ofthe ubiquitin pathway. It has also stimulated the development ofnew tools to help to better understand the complexmechanismssurrounding ubiquitin.
Webinar sponsored by Invitrogen
Youwill meetwith a panel of experts to:
• Learnmore about the role of ubiquitin in cellular processes.
• Find out the latest about efforts to find new drugs that targetthe ubiquitin pathway.
• Hear about the successful application of proteinmicroarraytechnology for discovering new substrates for ubiquitin ligases.
• Have your questions answered by the experts live and inreal time.
www.sciencemag.org/webinar
For more informationand complimentaryregistration visit:
Register now!
TheUbiquitin-Proteasome Pathway:Targets for Disease Treatment andNewTools for Discovery
Brought to you by the ScienceBusiness Office
Join our panel of experts in a LIVEonline seminar onMay 1, 200812 noon EDT, 9 amPDT, 5 pmGMT
TheUbiquitin-Proteasome
PathwayWEBINAR
Participating Experts:
Alfred Goldberg, Ph.D.Department of Cell BiologyHarvardMedical SchoolBoston,MA
Paul Andrews, Ph.D.AmgenCambridge,MA
Barry Schweitzer, Ph.D.InvitrogenCarlsbad, CA
PNASProceedings of the National Academy of Sciences of the United States of America
www.pnas.org
Cozzarelli Prize
CLASS I: PHYSICAL ANDMATHEMATICAL SCIENCES
Understanding the nanoparticle–protein
corona using methods to quantify
exchange rates and a�nities of proteins
for nanoparticlesTommy Cedervall, Iseult Lynch, Stina Lindman,Tord Berggård, Eva�ulin, Hanna Nilsson,Kenneth A. Dawson, and Sara Linse
(2007) PNAS 104:2050–2055
CLASS II: BIOLOGICAL SCIENCES
Müller cells are living optical �bers in the
vertebrate retinaKristian Franze, Jens Grosche, Serguei N.Skatchkov, Stefan Schinkinger, Christian Foja,Detlev Schild, Ortrud Uckermann, Kort Travis,Andreas Reichenbach, and Jochen Guck
(2007) PNAS 104:8287–8292
CLASS III: ENGINEERING AND APPLIED SCIENCES
Faceting ionic shells into icosahedra via
electrostaticsGraziano Vernizzi and Monica Olvera de la Cruz
(2007) PNAS 104:18382–18386
CLASS IV: BIOMEDICAL SCIENCES
Targeted delivery of proteins across the
blood–brain barrierBrian J. Spencer and Inder M. Verma
(2007) PNAS 104:7594–7599
CLASS V: BEHAVIORAL AND SOCIAL SCIENCES
Savanna chimpanzees use tools to harvest
the underground storage organs of plantsR. Adriana Hernandez-Aguilar, Jim Moore,and Travis Rayne Pickering
(2007) PNAS 104:19210–19213
CLASS VI: APPLIED BIOLOGICAL, AGRICULTURAL,
AND ENVIRONMENTAL SCIENCES
Incorporating plant functional diversity
e�ects in ecosystem service assessmentsSandra Díaz, Sandra Lavorel, Francescode Bello, Fabien Quétier, Karl Grigulis,and T. Matthew Robson
(2007) PNAS 104:20684–20689
2007 COZZARELLI PRIZE RECIPIENTS
The Proceedings of the National Academy of Sciences (PNAS) has selected sixoutstanding articles for the 2007 Cozzarelli Prize, in recognition of their scienti�c
excellence and originality. Winners were selected from the 3,600 research articlespublished in PNAS in 2007 and represent exceptional contributions to the six broadlyde�ned classes under which the National Academy of Sciences is organized.
From the publishers of Science, Science Signaling, formerly known as
Science’s STKE, will add original research starting September 2008.
Each week the journal will publish leading-edge findings in addition
to the current features, including Perspectives, Reviews, Protocols,
Meeting Reports, Book Reviews, Teaching Resources, and the
Database of Cell Signaling.
Science Signaling showcases high-impact research in cellular
regulation in such fields as molecular biology, development,
immunology, neuroscience, microbiology, physiology and medicine,
pharmacology, biochemistry, cell biology, bioinformatics, and systems
biology. Submit your research that provides new concepts and new
understanding of biological signal transduction for consideration.
Subscribing to Science Signaling ensures that you and your lab have
the latest cell signaling resources. From basic science to design of
therapeutics, from molecules to networks and systems design, read
the best source – Science Signaling.
Submit your paper to:stke.sciencemag.org/about/help/research.dtl
ISSN: 1937-9145
www.sciencemag.org/products SCIENCE VOL 320 18 APRIL 2008 389
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New Products Focus: Cell/Tissue Culture
LIFE SCIENCE TECHNOLOGIES
Vibration-Isolation WorkstationsSturdy, versatile, and ergonomic, this line of vibration-isolation workstationsfeatures automatic leveling and low natural frequencies for excellent vertical andhorizontal isolation efficiencies. The workstations can be configured for a widevariety of applications in which external vibrations could adversely affect theoperation of sensitive equipment. The Standard High-Performance Workstation isthe choice for most applications. A Heavy/Moving-Load Workstation is availableto isolate loads of up to 2,800 pounds, including equipment with high centersof gravity. The Personal Workstation is an economical solution for small labs andother tight spaces. A Variable-Height Workstation allows the user to raise or lowerthe tabletop to accommodate the height of the user. The Cleanroom Workstationis designed for use in Class 1 and Class 10 cleanrooms. The MK26 Workstationmakes use of the Minus K stiff spring and negative-stiffness mechanism toachieve low net vertical stiffness, ultralow natural frequencies, and high internalstructural frequencies without affecting the static load supporting capability.
Supercontinuum Confocal MicroscopeThe Leica TCS SP5 X confocal microscope with supercontinuum laserprovides freedom and flexibility that were unattainable until nowin fluorescence microscopy. The supercontinuum laser allows theresearcher to choose any excitation line within the continuous rangeof 470 nm to 670 nm. The Leica TCS SP5 X can precisely adapt toany fluorescent dye. Adjustment of the excitation line to the samplein 1 nm increments reduces cross-excitation and minimizes sampledamage. The system allows multicolor excitation with up to eightexcitation lines simultaneously. The patented Spectral DetectionTechnology provides the flexibility to choose any detection areain up to five spectral confocal photomultiplier tube channels. Thesystem includes the acousto-optical beamsplitter, a Leica inventionthat provides high sensitivity and better transmission than any otherdichroic mirror.LeicaFor information 800-248-0123www.leica-microsystems.com
Piezo Stage SystemThe NZ500CE NanoScanZ Piezo 500 micron stage system is aninnovation in microscope automation designed for researchersusing deconvolution and three-dimensional imaging techniques.The NanoScanZ Piezo 500 offers five-nanometer repeatability andclosed-loop control with a subangstrom resolution piezo resistivesensor. The stage provides piezo speed with a sample holder arealarge enough for well plates in addition to standard slides and petridishes. The500-micronmovement enables theNZ500CE to focus overan entire well plate without having to adjust the microscope focusmechanism. The stage complements the speed of the newest digitalcameras and accomplishes in milliseconds what would take secondsfor conventional rotary focus drives. By moving the sample insteadof the objective, the NanoScanZ offers advantages over objective-based piezo systems, including faster movement and settling and theflexibility to create Z stacks with multiple objectives.Prior ScientificFor information 781-878-8442www.prior.com
PFilter Set Tailored to NanocrystalsInvitrogen’s Molecular Probes Qdot 625 nanocrystal fluorescentlabel is matched to work with the Brightline fluorescence filter setfrom Semrock. This new label-filter combination allows the ultimatein brilliant imaging or quantitation by combining Invitrogen’s stableand technically advanced Qdot nanocrystal fluorescence labelingtechnology with Semrock’s matched “no burn out” high performance
Newly offered instrumentation, apparatus, and laboratory materials ofinterest to researchers in all disciplines in academic, industrial, and gov-ernmental organizations are featured in this space. Emphasis is given topurpose, chief characteristics, and availabilty of products and materials.Endorsement by Science or AAAS of any products or materials mentionedis not implied. Additional information may be obtained from the manufac-turer or supplier.
Electronically submit your new product description or product literatureinformation! Go to www.sciencemag.org/products/newproducts.dtl formore information.
fluorescence filters. Qdot fluorescence labeling products’ imagingperformance comes from their robust nanocrystal structure combinedwith a customizable surface. As one example of their wide range ofapplications, the Qdot 625 streptavidin conjugate fills an importantspectral gap for dense multicolor imaging experiments and exhibitsgreater brightness than the longer-wavelength Qdot nanocrystals.Coupled with Semrock’s high-brightness matched fluorescence filterset, these products are suitable for demanding experiments suchas live-cell, single-molecule dynamic imaging. The Qdot labels arenot only bright, but usable in applications that require long-termphotostability.Semrock and InvitrogenFor information 585-594-7003www.semrock.com
Multispectral Imaging System FXThe Kodak In-Vivo Multispectral Imaging System FX is a new digitalsystem for fluorescent molecular imaging that enables life scienceresearchers to study molecular abnormalities that are the origin ofdisease at a very early stage. The system is designed to preciselylocate and monitor changes in the molecular activity of specificcells or organs long before morphological changes can be detected,expediting the development of effective therapeutics for diseasetreatment.Thesystem’suniquemultispectral tuningof excitation lightgreatly enhances image sensitivity, allowing for the identification andseparation of multiple optical biological marker signals in subjectssuchassmallanimals,while removingbackgroundnoise.Thesystem’ssophisticated software automatically generates and analyzes a seriesof images taken at different wavelengths with spatially coregisteredX-ray and white light images for improved localization of biomarkersin vivo.Thesystem’smultimodal capabilities includebioluminescenceand radioisotopic signal detection.Carestream HealthFor information 877-747-4357www.carestreamhealth.com
Kinetic SystemsFor information 617-522-8700www.kineticsystems.com
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