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Diagnostic Criteria: Severe Community-Acquired
Pneumonia
Antonio Anzueto
The University of Texas Health Science Center at San Antonio, Texas
Our Secret weapon !!!
Diagnostic criteria SCAP
Are we aware of existing criteria and if so, do we use them ?
Validity of CriteriaWhere we need to go
Diagnostic criteria SCAP
Are we aware of existing criteria and if so, do we use them ?
Validity of CriteriaWhere we need to go
Aims
Hypothesis
To understand the perception of physician attitudes to define which patients with CAP should be admitted to the intensive care unit (ICU)
Significant variation among physicians occur regarding who
should be admitted to the ICU
DemographicsPractice variables No (%)
Profession
Physician 370 (98.7)
Other 5 (1.3)
Specialty
Pulmonary disease 290 (75.5)
Critical care 262 (68.2)
Type
Academic 161 (41.9)
Other
Location
Urban 220 (57.3)
Other 164 (42.7)
n=383
Aware and Use it!!
50
28 27
0
20
40
60
80
100
ATS 2001 APACHE PSI class V
Per
cen
tag
e
Aware and DO NOT Use it!!
7468 67
0
20
40
60
80
100
SAPS ATS 1993 APACHE
Per
cen
tag
e
NOT Aware and DO NOT Use it!!
77 74
45
0
20
40
60
80
100
CURB CURB-65 BTS
Per
cen
tag
e
Practice setting
63
51
69
56
87
71
0
10
20
30
40
50
60
70
80
90
BTS PSI class IV SAPS
Per
cen
tag
e
Academic (n=182) vs. Non-academic (n=203)
p=0.04 p=0.02 p<0.01
Conclusions
Criteria to define the need for ICU admission were infrequently reported by survey responders
Important differences were found in academic vs. non-academic practitioners regarding the criteria used to admit patients to the ICU with CAP
Implications
There is a need for more unified and appropriate criteria to define which patients with CAP require admission to the ICU
Diagnostic criteria SCAP
Are we aware of existing criteria and if so, do we use them ?
Validity of CriteriaWhere we need to go
Mortality and Care
0
5
10
15
20
25
30
Low Intermediate High
Risk of dying due to CAP
Home
Ward
ICU
Stratification CAP-PORT
Fine MJ, et al. N Engl J Med. 1997;336:243-250
Step-1Risk class I (lowest
severity level)Age < 50 yearsNo comorbid
conditions (neoplastic diseases, liver disease, congestive heart failure, cerebrovascular disease, or renal disease)
Normal or only mildly deranged vital signs and normal mental status
Step-2Not Risk class IClasses II-V
3 -Demographics5 -Comorbid
conditions5 -Physical exam
findings7 -Laboratory or
radiographic findings
Risk-class mortality rates
Risk Class
No. of points
Mortality%
Recommended site of care
I -- 0.1 Outpatient
II <70 0.6 Outpatient
III 71-90 2.8 Outpatient or brief inpatient
IV 91-130 8.2 Inpatient
V >130 29.2 Inpatient
Fine MJ, et al. N Engl J Med. 1997;336:243-250
Step-1 (Pre-morbid conditions) + Step-2 (PSI score) + Step-3 (Clinical judgment)
Mortality – CURB-65 score
0
5
10
15
20
25
0-1 2 > 3
Confusion; U rea (>19.1 mg/dL); Respirations (> 30 rpm); Blood pressure (DBP < 60); 65 years of age
CURB-65 ScoreLim et al. Thorax 2003 58:377
n=1,068
n=324
n=184
n=210
Severe Pneumonia Criteria
MAJORMechanical ventilationMultilobar or increase
infiltrates >50% in 48h
Septic Shock or need for vasopressors >4h
Acute renal failure
MINORSBP < 90 mm Hg• DBP < 60 mm Hg• RR >30/min
PaO2/FiO2 < 250
Bilateral or multilobar infiltrates
1 of 2 major criteria 2 of 3 minor criteria
ATS guidelines. AJRCCM. 2001;163:1730-1754
Methods
Study Design A retrospective observational cohort study
of patients hospitalized at a two teaching hospitals in San Antonio, Texas
VA medical center and county-run referral hospital
Admission between Jan 1, 1999 and Dec 31, 2001
Study was approved by the institutional board review
DemographicsVariables Alive
n= 714 (%)
Deadn=72 (%)
p value
Age in years, mean + SD 60 + 16 63 + 16 0.09
Sex, n (%) male 561 (79) 60 (83) NS
Nursing home resident 41 (6) 13 (18) < 0.001
Admission thru ED 598 (84) 58 (81) NS
ICU admission within 24 h 118 (17) 36 (50) < 0.001
n=787
NS=p>0.05
Predictors FrequencyPredictors 30-day
Mortality, n (%)
ICU admission
, n (%)
CURB-65 Group 1 (scores 0-1) 20/461 (4) 63/461 (14)
CURB-65 Group 2 (scores 2) 29/187 (15) 47/187 (25)
CURB-65 Group 3 (scores 3-5) 20/116 (17) 36/116 (31)
CURB-65 Group 3 (scores 4-5) 5/23 (22) 9/23 (39)
rATS – Severe CAP criteria 21/74 (28) 70/74 (95)
PSI low risk class (I-III) 16/409 (10) 44/409 (11)
PSI moderate risk class (IV) 26/266 (10) 62/266 (23)
PSI high risk class (V) 30/112 (27) 48/112 (43)
n=787
ICU admission*
ICU admission Sn
(%)
Sp
(%)
PPV
(%)
NPV
(%)
ROC
(95% CI) Criteria rev. ATS 53 94 67 89 0.73
(0.68-0.78) Criteria CURB-65 6 98 39 81 0.59
(0.54-0.64) PSI high class V 31 90 43 84 0.67
(0.63-0.72)
* Sn, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; ROC, receiver operating curves
30-day Mortality *
ICU admission Sn
(%)
Sp
(%)
PPV
(%)
NPV
(%)
ROC
(95% CI) Criteria rev. ATS 39 87 23 93 0.63
(0.55-0.70) Criteria CURB-65 7 97 22 91 0.66
(0.59-0.73) PSI high class V 42 88 27 94 0.71
(0.65-0.78)
* Sn, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; ROC, receiver operating curves
ICU admission
ICU admission Sn
(%)
Sp
(%)
PPV
(%)
NPV
(%)
ROC
(95% CI) Criteria rev. ATS 53 94 67 89 0.73 (0.68-0.78)
Criteria rev. ATS 71 72 26 95 0.68 (0.64-0.73)
CURB-65 (4-5 criteria) 6 98 39 81 0.59 (0.54-0.64)
CURB (3-4 criteria) 40 78 20 90 0.58 (0.53-0.63)
PSI high (class V) 73 53 18 93 0.60 (0.56-0.65)
PSI high (class V) 73 53 18 93 0.60 (0.56-0.65)
Restrepo CURENT vs. Angus et al. AJRCCM 2002
Best severity predictors
Events Best Criteria ROC (95% CI)
ICU admission
Criteria rev. ATS 0.73 (0.68-0.78)
ICU admission
Criteria rev. ATS 0.68 (0.64-0.73)
30-day Mortality
PSI high (IV or V) 0.71 (0.65-0.78)
Death PSI high (IV or V) 0.75 (0.71-0.78)
Restrepo CURRENT vs. Angus et al. AJRCCM 2002
Diagnostic criteria SCAP
Are we aware of existing criteria and if so, do we use them ?
Validity of CriteriaWhere we need to go
CURXO - 80
C – ConfusionU – Urea > 30 mg/dlR – Resp rate > 30/minX – X Ray – multilobar, bilateralO – PaO2/FiO2 < 25080 – Age > 80 Years
Espana et al. AJRCCM 2006;174:1249
Charles et al CID 2008; 47:375
Need for Intensive respiratory -Vasopressors support(IRVS)
Need for Intensive respiratory -Vasopressors support, IRVS
Charles et al CID 2008; 47:375
Predicting 30 day Mortality
Charles et al CID 2008; 47:375
AUC analysis severity assessment
Charles et al CID 2008; 47:375
Procalcitonin (PCT)
Stimulated by bacterial endotoxinViral and localized infection have lower PCT
levels than systemic infectionsAutoimmune and neoplastic disease do not
induceShort half life
PCT and Diagnosis
Nyamande Int J TB Lung Dz 2006; 10: 510
0
5
10
15
20
25
PCT (ng/ml)
PCP
TB
Bacterial Pneumonia
P=0.0004
PCT and Antibiotics
RCT to examine whether PCT guidance associated with less antibiotic use
PCT strata <0.1- Antibiotics strongly discouraged0.1-0.25- Antibiotics discouraged0.25-0.5- Antibiotics advised>0.5- Antibiotics strongly recommended
Christ-Crain AJRCCM 2006 174: 84
PCT and Antibiotic Discontinuation
PCT/CRP and Treatment Failure
Prospective cohort of 453 CAP patients18% treatment failures
CRP & PCT higher in failuresDay 1
» CRP: 13.6 vs. 23.2» PCT: 0.5 vs. 1.5
Day 3» CRP: 4.5 vs. 12.1» PCT 0.3 vs. 0.5
Menendez Thorax 2008; 63:447
Conclusions
Revisited ATS rule has the best power to predict the need for ICU admission
PSI score is the best predictor for mortality due to CAP
The CURB-65 rule may be used as an alternative tool to the PSI for the detection of low risk patients, but is not a good rule to define ICU admission
Conclusions
Described rules are imperfect and have significant limitations due to the the difficult of application to individual patients
Further studies are needed to develop clinical prediction tools for high-risk patients requiring ICU admission
Obrigado