Diagenode Epigentic Solutions

Diagenode Epigenetic Solutions

Business focusDeveloping and commercializing well-differentiated, high-value products for epigenetics research (and diagnostics in Europe)

Core competenciesStrong industry and application expertise; sonication experts; R&D and scientific leadership in epigenetics

Commercial successHigh-profile customer base, market leadership in epigenetics, trusted reputation in sonication; quality ChIP-grade antibodies & kits

Innovative productsSX-8G IP-Star™ and SX-8G IP-Star™ Compactautomated systems for ChIP and methylation assays and Bioruptor®NGS for the next generation sequencing market

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Diagenode Overview

• Privately held Belgian Biotech company

• Started in June 2003• Located at the building• Subsidiary in US: Diagenode Inc• 40 employees

Diagenode complete epigenetic solutions

Diagenode Belgium

Diagenode Inc.USA

Where we are

Sales offices

Distributors

© Diagenode. All rights reserved. Confidential not for replication or duplication.



Diagenode: R&D Innovation and CollaborationReinforce Industry Leadership

Recent EU Consortium Grants in Epigenetic Researchs Including Diagenode as Co-Investigator

EU Grants Awarded


DNA/RNA/cDNA Chromatin

Shearing with Bioruptor®

(controlled size fragments)

ChIP assay with Diagenode’s kits

Shearing with Bioruptor®

(controlled size fragments)

MeDIP, MethylCap assay with Diagenode’s kits

ChIP or Methylation Assay automation with IP-star

Next-gen sequencing library prep. Automation

with IP-Star

From sample to results


Diagenode Bioruptor Shearing systems and SX-8G IP-Star Automated Platforms

for Epigenetic Applications


A key company goal:

Making epigenetics accessible, automated and

consistent

Over 200 publications cite the Bioruptor in many biological applications

Bioruptor® Sonicator product range

11: 115 bp

10: 135 bp

9: 183 bp

8: 200 bp

7: 234 bp

6: 319 bp

5: 476 bp

3: 848 bp

2: 1038 bp

1: 1230 bp

4: 696 bp

Bioruptor®

NGS produces DNA fragments in a broad size range from 100 bp to 1200 bp

Bioruptor®NGS for Next Generation Sequencing market


Bioruptor®NGS and Bioruptor® Standard are compatible with

PGM™ system

Bioruptor® Sonicator product range

Broadest range ever for consistent DNA hydroxymethylation and DNA methylation studies

Kits & reagents

Low Cell ChIP kit One Day CIP kit

1000Cell nr

1x106 2x106 10x1065x106

High Cell ChIP kit

Recover more DNA from a single ChIP experiment in a Magnetic format

Kits for Chromatin Immunoprecipitation

Kits & reagents

Diagenode is recognized as the “best-in-class” epigenetic antibody company

ChIP-seq comparison of different batches

H3K9/14ac

H3K9/14ac

H3K9/14ac

Kits & reagents

SX-8G IP-Star® CompactSX-8G IP-Star®

Diagenode Automated Platforms for Epigenetic Applications

SX-8G IP-Star™ Automated Platforms forEpigenetic Applications

25 SX-8G IP-Star Units around the world



Intuitive touch screen panelSoftware training not required

Ideal systems for protocol optimization: researcher can define key experimental parameters

SX-8G IP-Star™ Compact

Mixing is achieved by continuous pipetting ofreagents throughout the incubation

Washing is achieved by capturing the beads with the magnet and dispensing reagents.

Magnetic separation technology


Bioruptor™

Sonicator

IP-Star™


Dispense only bead , antibody and chromatin in the reagents manually in a 12x 200-µl tubes strip

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12

(Front view)

Easy and fast reagents preparation!

Reagents preparation in tube strips


Fully validation of SX-8G IP-Star Automated by researchers



A key company goal:

Making epigenetics easy, accessible, automated and

consistent

Diagenode Bioruptor Shearing systems and SX-8G IP-Star Automated Platforms

for Epigenetic Applications

THANK YOU FOR YOUR ATTENTION

Documents

Diagenode Epigentic Solutions