8/18/2019 Diabetes Research Study Final

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AIM: - Whether modest weight loss through dietary changes and increased

physical activity or treatment with the oral diabetes drug metformin

(Glucophage) could prevent or delay the onset of type 2 diabetes mellitus in

study participants.

STUDY DESIGN: - 323! study participants from 2" clinical centres around the

united states were randomly divided into di#erent treatment groups

Group A- called the lifestyle intervention group received intensive training in

diet physical activity and behavioural modi$cationGroup B- too% &' mg of metformin twice a day

Group C- received placebo pills instead of metformin

RESULTS: -

Group A- is% of developing diabetes was reduced by 58% . *bout 5% of this

group developed diabetes each year during the study period as compared with

++, of those in the placebo group

Group B- is% of developing diabetes was reduced by 31%. *bout 7.8% of this

group developed diabetes each year during the study period as compared with

++, of those in the placebo group

Group C- 11% of this group developed diabetes every year.

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INTERPRETATI)N:-

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8/18/2019 Diabetes Research Study Final

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