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Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Developmentofanelastographybenchforhistologyandengineered6ssuestudy–Preliminaryresults
MathildeBigot1,HugoDorez1,CélineMandon²,ChristopheMarque;e²,KevinTseVeKoon1,PaulineM.Lefebvre1,DenisGrenier1,HamzaRaki1-3,FabienChauveau4,OlivierBeuf1,SimonA.Lambert11Univ.Lyon,INSA-Lyon,UniversitéClaudeBernardLyon1,UJM-SaintEVenne,CNRS,Inserm,CREATISUMR5220,U1206,FF-69000,LYON,France.2UniversitéLyon1,CNRS,INSA,CPE-Lyon,ICBMS,UMR5246,43Boulevarddu11Novembre1918,69622VilleurbanneCedex,France3Buc,FR,GeneralElectricHealthcare.4LyonNeuroscienceResearchCenter,CNRSUMR5292,INSERMU1028,Univ.Lyon1,Lyon,France
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 2
Context Calfbrain Bovine
liver
Bovinemuscle
Humanliver
Porcinebrain
1-Schmidtetal.,ISMRMproc.,20172-Guertleretal.,ISMRMproc.,20173-Rieketal.,J.Biomech.vol44,2011
[1]
[2]
[3]
• Elastography:• MechanicalexcitaVon• MRIimagingViscoelasVcproperVes
• Phantomandexvivostudies:• HighspaValresoluVon• Higherfrequency
• Devices:• Easytohandle• Cheap
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 3
• ExcitaVon:• Piezoelectric• Needle
• 3D-printeddevice:• Helmholtzcoil• Sampleholder• Couplingloop
• Tuning• Matching
Elastography bench
COST<150€
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 4
FLASH 3D
Voxel:0.312x0.312x0.625mm3
SNR:83
TR/TE:15/6ms-Acq.Vme:2minutes-α=15°
Voxel:0.312x0.312x0.625mm3
SNR:64
Bioengineeredgel
Commercialgel
Ratbrain
Agarose1.5%
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 5
Bioengineeredgel
Commercialgel
Turbo Spin Echo Elastography
Totaldisplacementmagnitude<A>=3.8µm|G*|=1.4±0.5kPa
TR/TE:2000/18ms-f=600Hz-Acq.Vme:17minx3dir.
|G*|(Pa)
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 6
Turbo Spin Echo Elastography
<A>=5.6–1.6µm
TR/TE:2000/(18-24)ms-f=600-1000Hz-Acq.Vme:17minx3dir.
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 7
Millwardetal.,NMRBiomed.,vol282015
900Hz,Li;.1000Hz
Turbo Spin Echo Elastography Cerebrum vs cerebellum | 𝐺↓↑∗ |↓𝑐𝑒𝑟𝑒𝑏𝑟𝑢𝑚 > | 𝐺↓↑∗ |
↓𝑐𝑒𝑟𝑒𝑏𝑒𝑙𝑙𝑢𝑚 Similardispersion
Cerebrum
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 8
Turbo Spin Echo Elastography Hippocampus vs Cortex
900Hz,Lit.800Hz1000Hz
1-Bouletetal.,J.Neurosci.Methods,vol201,20112-Munderetal.,J.Magn.Reson.Imaging,2017
900Hz,Lit.1000Hz
Hippocampus
AgreementG’
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 9
Turbo Spin Echo Elastography
Commercialgel
Agarose1.5%
<A>=25.5µm-|G*|=7.3±3.9kPa
TR/TE:2000/18ms-f=600Hz-Acq.Vme:17minx3dir.
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 10
• Easiermatching• Cellsurvivalset-up• Cooling
Perspectives HeaVng
MonitoringCO2
Medical Imaging Research Laboratory Medical Imaging Research Laboratory www.creatis.insa-lyon.fr
Context Method Results Perspec6ves
08/11/2017 CNIV-MathildeBIGOT 11
Thank you for your attention
