drug prescribing HOW WELL DO ELDERLY PATIENTS TAKE OXPENTIFYLLlNE? Oxpentifylline (pentoxify ll ine, 'Trental', 'Torental'; Hoechst) is an approved treatment for geriatric cerebral problems in many countries. Compliance to treatment was considered good (fewer than 30 tablets retu rned) in 62 % of 1662 elderly French patients with ce rebral symptomalOlogy. They were asked to 'take 4 tabletS daily f or 4 weeks and given the drug in small plas ti c boxes containing 40 tablets or 12 tinfoil str ips of 10, with or without memory aid stickers. AUunconsumed tablets were to be returned. • 83. 1 % of patients brought back leftover drug. This proportion was not influenced by packaging type or memory aid stickers. • Compliance was not inO uenced by packag ing type or memory aid sticke rs. • Compliance was not related to age Of sex or number of co-therapi es, but was related to pretreatment memory sco re (p < 0.05). • Qinical improvement (very sa ti s factory in 18.6 % of eases, satisfactory in 52.6 % , null or neglig ible in 27.2 %, worse in 1.6 96 ) was not related to drug packaging. • There was a correlation between co mpliance and cli ni cal improvement, a nd a significant inverse correlati on betwee n com pliance and freque ncy of side effects. The latter indicates that patients stop taking a drug if they think it causes adverse effectS. Spriel, A. Clinical PltarmaoolQt:yand Therapeutics 27: I Oan 1980) 4 INPHARMA 9 Feb 1980 0156-2703/ 80/0209-0004 $00.50/0 C ADIS Press

DESPITE RECOMMENDATIONS YOUNG CHILDREN ARE STILL GIVEN TETRACYCLINE

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Page 1: DESPITE RECOMMENDATIONS YOUNG CHILDREN ARE STILL GIVEN TETRACYCLINE

drug prescribing

HOW WELL DO ELDERLY PATIENTS TAKE OXPENTIFYLLlNE?

Oxpentifylline (pentoxifyll ine, 'Trental', 'Torental' ; Hoechst) is an approved treatment for geriatric cerebral problems in many countries. Compliance to treatment was considered good (fewer than 30 tablets retu rned) in 62 % of 1662 elderly French patients with cerebral symptomalOlogy. They were asked to 'take 4 tabletS daily for 4 weeks and given the drug in small plastic boxes containing 40 tablets or 12 tinfoil strips of 10, with or without memory aid stickers. AU unconsumed tablets were to be returned.

• 83. 1 % of patients brought back leftover drug. This proportion was not influenced by packaging type or memory aid

stickers. • Compliance was not inOuenced by packaging type or memory aid stickers. • Compliance was not related to age Of sex or number of co-therapies, but was related to pretreatment memory score

(p < 0.05). • Qinical improvement (very satisfactory in 18.6 % of eases, satisfactory in 52.6% , null or negligible in 27.2 %, worse in

1.6 96 ) was not related to drug packaging. • There was a correlation between compliance and clinical improvement, and a significant inverse correlation between

compliance and frequency of side effects. The latter indicates that patients stop taking a drug if they think it causes adverse effectS.

Spriel, A. el~l .: Clinical PltarmaoolQt:yand Therapeutics 27: I Oan 1980)

4 INPHARMA 9 Feb 1980 0156-2703/ 80/0209-0004 $00.50/0 C ADIS Press