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Dermawhite™ WFThe power of nature to illuminate your skin
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Conclusion
BASF Personal Care
BASF Personal Care3
Market for skin lightening products
0%
10%
20%
30%
40%
50%
60%
70%
80%
Use frequency by women
(United Nations Environment Program, Geneva, 2008)
80 % of all skin-whitening sales within Asia are generated in India.
77 % of all skin-whitening sales within Africa are generated in Nigeria.
“Global Beauty Industry Trends in the 21st Century”, report 2013
The global skin lighteners market is projected to reach US$19.8 billion by 2018, driven by the growing desire for light-colored skin among both men and women primarily from the Asian, African and Middle East regions.
“Companies and Markets”, report 2013
BASF Personal Care4
Need for safe and affordable cosmetic ingredients
Whiteness at a high price
Over-promising products containing
partly questionable ingredients such as-hydroquinone, steroids and mercury compounds.
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Conclusion
BASF Personal Care
BASF Personal Care6
Carica Papaya
Psidium Guajava
Saxifraga Sarmentosa
Dermawhite™ WFThree white flowers for white skin
BASF Personal Care7
Psidium GuajavaPsidium Guajava
• Names:Common guava, yellow guava, lemon guava
• Flower:May bloom and set fruit in as few as 2 years
• Main constituents:Vitamins, tannins, phenolic compounds, flavonoids, essential oils, sesquiterpene alcohols and triterpenoid acids
• Traditional uses: Traditional Chinese medicine Astringency, healing and skin repair Antimicrobial properties Mexico: Leaves are said to be a remedy for itches Amazon, Brazil: A decoction of the bark and/or leaves
or a flower infusion is used topically for wounds, ulcers and skin sores
• Cosmetic science:Excellent tyrosinase inhibitor
In Dermawhite™ WF: Fruit extract
Dermawhite™ WFThree white flowers for white skin
BASF Personal Care8
Carica Papaya Carica Papaya
• Name:Papaya
• Main constituents:Pro-vitamin A carotenoids, vitamin C, folate, lycopene and polyphenols
• Traditional uses: Traditional Chinese medicine Treatment of cuts, rashes, stings and burns Mashed papaya used by the Asian and Pacific
populations to lighten the skin complexion and age spots Cataplasm to cure cutaneous disorders In some parts of Asia, the young leaves of the papaya
are steamed and eaten like spinach• Cosmetic science:
Known tyrosinase inhibitor
In Dermawhite™ WF: Fruit extract
Dermawhite™ WFThree white flowers for white skin
BASF Personal Care9
In Dermawhite™ WF: Extract of entire plant
Saxifraga sarmentosaSaxifraga sarmentosa
• Names:Creeping Rockfoil, Aaron's beard, Mother of Thousands, Roving Sailor, Wandering Jew, Strawberry Begonia, Strawberry Geranium
• Plant:Growing at an altitude of 390–3600 m in China, Russia, Japan and Korea
• Traditional uses: Wound healing Traditional Chinese medicine; treatment of measles,
tympanitis, erysipelas, hemoptysis, piles, and hair fall• Cosmetic science:
Strong tyrosinase inhibitor
Dermawhite™ WFThree white flowers for white skin
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Conclusion
BASF Personal Care
BASF Personal Care11
B16 melanocytes; 72 hrs incubation; measurement of total melanin via optical density at 475 nm
-90%
-25%
Dermawhite™ WFMelanin synthesis (in vitro)
0.001 % DermawhiteTM WF inhibits 90 % melanin synthesis
DermawhiteTM WF is more than 3 times more effective than kojic acid
BASF Personal Care12
Mid to long term clinical studyProtocol
Instrumental evaluationChromameter measurement of L* & ITA° on the face & on the untreated neck control site
Volunteer panel:• 34 Indian women, Phototype IV-V
Test products:• O/W emulsion (Placebo)• O/W emulsion + 2% Dermawhite™ WF
Application:• Double-blind, randomized, split face, twice
daily during 84 days
Placebo creamDermawhite™ WF
at 2%
METHOD
Non-treated control site Reference area to normalize instrumental results independently of variations of skin color due to
external factors during the study period.
Evaluation at D0, D28, D56, D84
BASF Personal Care13
34 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, chromametry
Mid to long term clinical studyResults versus placebo / Chromametry
Whitening efficacy of DermawhiteTM WF is significantly better than placebo
+1,1% vs.D0
+0,2%vs. D0
+21,6% vs.D0
+2,6%vs. D0
BASF Personal Care14
Short to mid term clinical studyProtocol
Instrumental evaluationChromameter measurement of L* & ITA° on the face & on the untreated neck control site
Clinical evaluation:Color evaluation by an expert, scale from 1 to 10 (1=dark skin/10=fair skin)
Evaluation by volunteers: Volunteer self assessment
Volunteer panel:• 32 Indian women, Phototype IV-V
Test products:• O/W emulsion + 2% Kojic Acid (benchmark)• O/W emulsion + 2% Dermawhite™ WF
Application:• Double-blind, randomized, split face, twice
daily during 56 days
Kojic Acid at 2%
Dermawhite™ WF at 2%
METHOD
Non-treated control site Reference area to normalize instrumental results independently of variations of skin color due to
external factors during the study period.
Evaluation at D0, D14, D28, D56
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Chromametry results
32 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, chromametry
Short to mid term clinical studyResults versus kojic acid / Chromametry
After 14 days, the whitening efficacy of 2 % of DermawhiteTM WF is significantly better than 2 % kojic acid
+1,8% vs.D0
+0,8%vs. D0
+51,0% vs.D0
+20,9%vs. D0
BASF Personal Care16 16
32 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, dermatological evaluation
Short to mid term clinical studyResults versus kojic acid / Dermatologist
Light skin
Dark skin
34%
25%
12%
2 % of DermawhiteTM WF match the whitening effect of 2 % kojic acid
BASF Personal Care17 17
32 Indian females ages 30-60, phototype IV and V, split-face, twice daily applications, volunteers’ self-assessment at day 14
Short to mid term clinical studyVolunteers’ evaluation after 14 days
After 14 days, the effects of 2 % of DermawhiteTM WF are perceived by almost all volunteers and are rated better than 2 % kojic acid
BASF Personal Care18
Before After 56 days
Before After 56days
Improvement Delta
Measured L* 48.2 50.3 2.1
Measured ITA° -4.9 0.9 5.8
Dermatological rating 3 6 100%
Short to mid term clinical studyAverage panelist result
Visible whitening effect of 2 % of DermawhiteTM WF
Example of color change after 56 days
1 | The Challenge
2 | The Solution
3 | Efficacy Data
4 | Summary
BASF Personal Care
In vitro
In vivo
• DermawhiteTM WF inhibits 90 % melanin synthesis – 3x more effective than kojic acid
• Quantitative measurement - Whitening and luminescence efficacyof DermawhiteTM WF is significantly better than placebo
• Quantitative measurement - After 14 days, the whitening efficacy of 2 % of DermawhiteTM WF is significantly better than 2 % kojicacid
• Clinical evaluation by a dermatologist - 2 % of DermawhiteTM WF matches the whitening effect of 2 % kojic acid
• Self evaluation - After 14 days, the effects of 2 % of DermawhiteTM
WF are perceived by almost all volunteers and are rated better than 2 % kojic acid
Dermawhite™ WFSummary of Tests
Dermawhite™ WFThe power of nature to illuminate your skin
Benefits & Unique Selling Points
Prevents melanin production 3x more effectively than kojic acid Significant whitening and luminescence benefits Clinically proven by a dermatologist to be as effective as kojic acid Panelist satisfaction better than kojic acid
China / Japan Regulations
INCI: Water (and) Tartaric Acid (and) Disodium EDTA (and) Sodium Sulfite (and) Sodium Metabisulfite (and) Glycerin (and) Butylene Glycol (and) SaxifragaSarmentosa Extract (and) Carica Papaya (Papaya) Fruit Extract (and) Psidium Guajava Fruit Extract
Dose of use: 2%
Solubility: water-soluble
Preservatives: none
Product Properties
Body Care
Applications
Face Care
Wipes
Color Care
Formulation InstructionsIncorporate at the end of the formulation at room temperature under gentle stirring. Optimal pH is 6.5-8.5.
PCPC INCI 2007
INCI 2010 Not listed Jap.
Pharma.
IECIC2014
IECIC 2012
IECSC Japan QD additive
X X
BASF Personal Care22
DISCLAIMER
This document, or any answers or information provided herein by BASF, does not constitute a legally binding obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, they are provided for your guidance only. Because many factors may affect processing or application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose prior to use. It does not relieve our customers of the obligation to perform a full inspection of the products upon delivery or any other obligation. The claims and supporting data provided in this publication have not been evaluated for compliance with any jurisdiction’s regulatory requirements and the results reported may not be generally true under other conditions or in other matrices. Users must evaluate what claims and information are appropriate and comply with a jurisdiction’s regulatory requirements. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA, OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERM SAND CONDITIONS OF SALE.
BASF Personal Care
23 BASF Personal Care