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Department of Life Sciences Biological Sciences
– Botany, Zoology, Marine Biology, Microbiology, Biochemistry, Molecular and Cell Biology, etc.
Agricultural Sciences– Agronomy, Horticulture, Forestry, Fishery, Animal Husbandry, Veterinary Science, Agricultural Chemistry, Food Science, etc.
Medical Sciences– Basic Medical Sciences: Anatomy, Physiology, Pharmacology,
Biochemistry, Microbiology and Immunology, Molecular Medicine, Epidemiology, Public Health and Occupational Medicine, Legal Medicine and Forensic Science, etc.
– Clinical Sciences: Internal Medicine, Surgery, Radiology, Nuclear Medicine, Gynecology and Obstetrics, Pediatrics, Dentistry, etc.
National Science and Technology Programs– Agricultural Biotechnology, – Genomics Medicine, – Pharmaceutical Biotechnology.
1996-2005 Annual Budget, Dept. of Life Sciences
49,58857,028
66,43777,431 77,960
87,918 90,533
108,101108,477115,264
0
50,000
100,000
150,000
1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
(Thousand USD)
2,820
4,7984,7194,5904,348
3,1622,9442,786
4,157 4,900
3,684
2,246 2,8532,9362,790
2,2012,0692,016
2,601
3,1232,842
1,467
65%
72%70%
68% 64%64%
70% 71%
58%65%
60%
0
1000
2000
3000
4000
5000
6000
`96 `97 `98 `99 `00(1)̀ 00(2) `01 `02 `03 `04 `05Year
(Grant Number)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Application Numbers
Funding Numbers
Funding Rate ( % )
Life Sciences Grant Applications and Funding
Department of Life SciencesFunding Policy Individual Grant Program Project Frontier Science Program Team of Excellence Program Inter-ministerial Health Food R & D Program Inter-disciplinary Integration Program International(Bilateral) Collaboration ProgramIndustrial-University Collaboration R & D ProgramBiotechnology Successful Investment Program National Science and Technology Research Program Genomic Medicine S & T Research Program Biotechnology Pharmaceuticals S & T Research Program Agriculture Biotechnology S & T Research Program
Bioengineering Program Project
To focus on research fields with integrated efforts of inter-departments, inter-institutes, and inter-universities.
To promote international collaboration
Major research areas:1. Functional tissue/molecular imaging2. Mobile monitoring and distributing wireless
integrated sensors system3. Biomedical optics and biophotonic monitoring
systems4. New biomechanics of tissues, cells, and genes5. Tissue and cell engineering and new
biomaterials
6
Bioinformatics Multidisciplinary Research Programs
Genome annotation and development of its tools
Microarray and proteomic data analysis and value-added data bank
Macromolecular sequencing and structural data analysis
Phylogenetic data analysis
Industry-University Cooperative Research Program
To promote advanced and applied technology research by the academic community, and also to encourage enterprises to actively participate in applied academic research, and thereby to enhance the R&D capabilities and skilled manpower of private sectors.
8
The Budget for the National Science and Technology Program
million USD
NSTPAB : National Science and Technology Program for Agricultural BiotechnologyNSTPBP : National Science and Technology Program for Biotechnology and Pharmaceuticals
NRPGM : Nation Research Program for Genomic MedicineSARS : SARS Research Project
Year 2000 2001 2002 2003 2004 2005 2006NSTPAB 5.31 3.85 4.57 9.47 10.97 6.67 6.81 NSTPBP 4.29 3.10 6.58 4.48 6.25 8.14 7.50 NRPGM - - 56.49 53.40 36.00 36.80 31.25 SARS 2.35
Agricultural Biotechnology National Program
Fifteen Research Teams
Development and integration of floral (Chrysanthemum and orchids) production and marketing systems.
Integration and industrial application of conventional and genetic-engineered post-harvest technology for vegetables and fruits.
Integration of key techniques for organic farming (e.g. stress tolerant varieties, bioprotectants and biofertilizers).
Promotion and establishment of production systems for high quality Chinese herbs and health foods.
Development of fry production systems with quality assurance (shrimp and grouper) and related transportation and marketing technology.
Biotechnology applications in the production of Taiwan tilapia for international market.
Application of biotechnology in the improvement of cage-culture and processing technology for Cobia.
Agricultural Biotechnology National Program
Fifteen Research Teams Agricultural waste treatments in generating value-added by-
products. Inventing and improving production systems for high quality
swine and chicken. Developing biological agents (vaccines and adjuvants) for
plant- and animal-related applications. Application of transgenic technology for ornamental plants
and fishes, and for medical and feed industries. Development of molecular techniques for diagnostic systems
and marker-assisted breeding. Development of bioreactor technologies for producing
industrial and medical materials. Establishment of GMO assessment and accrediting systems. Research and development of novel functional genomics
based technologies for biotechnological industries.
D.C.N. Chang
SWEET RICEtransgenic rice seeds expressing
an amylopullulanase (APU) gene
S.M. Yu and J.F. Shaw
National Program in Biotechnology and Pharmaceuticals(1999-2006)
• Natural Products • Synthetic Chemicals • Protein Drugs• Protein Chips• Drug Screening and Evalulation• Clinical Trials • Industrial Applications and Technology
Transfer
R&D on YC-1 and its Derivatives Project
Academics : China Medical University ( Sheng-Chu Kuo ), National Taiwan University College of Medicine ( Che-Ming Teng )
Enterprise : Health BioX Biotech. Co. ( Fang-Yu Lee )
Niche : PCT patents with multi-indications, over 170 international SCI papers acknowledgements
Challenge : Compete with other pharmaceutical companies such as Aventis and Bayer etc.
Targets: 1. YC-1 clinical trial (US and Taiwan)
2. R&D on follow-up YC-1 derivatives
3. Establishment of a R&D Center
Project for Development of Microfluidic Biochip Systems
Academy : National Cheng Kung University ( Gwo-Bin Lee, Shu-Hui Chen, Jiunn-Jong Wu, Ching-Hsing Luo, Mei-Ling Tsai, Jyh-Ming Ting, Chih-Ching Chang )Enterprise : President Biosystem Inc.Niche: 7 patents (10 in patent application process) Challenge : Competition with overseas companiesTargets: 1. Develop a series of advanced biochip systems 2. Development of biochips for early detection of virus/bacteria –
related diseases.The developed microfluidic biochip systems have successfully demonstrated their capability for fast diagnosis of virus/bacteria-related diseases. This project will collaborate several local companies to start up a competitive bio-MEMS company.
Sensor Heaters可攜式細胞前處理及 PCR模組
PCR 溫度控制元件照片Portable apparatus for cell pretreatment and PCR chips.
National Science and Technology Program
on Genomic Medicine (2002 - 2009)
CANCER
LIVERLUNG
ELSI
INFECTIOUS DISEASES
HIGHLY HERITABLE DISEASES
INNOVATIVE RESEARCH
IndustrialCooperation
InteranationalCooperation
Core facilitiesThe National Program attempts to coordinate national resources and to fund projects that are in line with Taiwan’s strategic development. Comprehensive cores have been established to support various scientific programs.
Six major core facilities:
Mutant Mouse Facility and Disease Models Clinical Tissues Bank High Throughput Genomics Facilities Proteomics and Structural Biology Facilities Bioinformatics Innovation and Key Technology Development
Result in Lung Cancer1. Many tumor suppressor genes (TSGs) had 5’CpG hypermethylation
in their promoter and/or exon1 regions in lung cancer. 2. These TSGs are: hMLH1 and hMSH2, p16INK4a), p14ARF, FHIT,
BLU, RASSF1A, RARβ, HIF, SLIT2, BRCA1/2.3. Overexpression of DNA methyltransfer enzymes (DNMTs)
contributes to NSCLC tumorigenesis and associate with 5’CpG hypermethylation in their target TSGs.
The mRNA and protein of DNMTs were highly expressed in tumor tissue.
ENU mutagenesis established mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. (J. Clin. Invest. 2004)
ENU mutagenesis mouse models of human metabolic disease