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U N I V E R S I T Auml T S M E D I Z I N B E R L I N
Apothekerkammer Berlin
Botanisches Museum 19022020
Prof Dr Oliver PetersChariteacute ndash Universitaumltsmedizin BerlinKlinik fuumlr Psychiatrie und Psychotherapie
Demenzerkrankungen und
therapeutische Moumlglichkeiten
Aumlnderung der Altersverteilung
Aumlnderung der Altersverteilung
Hallauer 2001
2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050
Age (years)
90+ 85-90 80-85 75-80 70-75 65-70
Patie
nts
in 1
000
2500
2000
1500
1000
500
0
Prognose der Demenzpraumlvalenz
Prognose Demenzerkrankungen 2025
Praumlvalenz(per 100000)
Anstieg in (bis 2025)
Quelle Demenz Report Berlin-Institut 2011
Potential for dementia prevention
Norton et al Lancet 2014
13
1914
8
5 3
2
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Aumlnderung der Altersverteilung
Aumlnderung der Altersverteilung
Hallauer 2001
2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050
Age (years)
90+ 85-90 80-85 75-80 70-75 65-70
Patie
nts
in 1
000
2500
2000
1500
1000
500
0
Prognose der Demenzpraumlvalenz
Prognose Demenzerkrankungen 2025
Praumlvalenz(per 100000)
Anstieg in (bis 2025)
Quelle Demenz Report Berlin-Institut 2011
Potential for dementia prevention
Norton et al Lancet 2014
13
1914
8
5 3
2
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Aumlnderung der Altersverteilung
Hallauer 2001
2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050
Age (years)
90+ 85-90 80-85 75-80 70-75 65-70
Patie
nts
in 1
000
2500
2000
1500
1000
500
0
Prognose der Demenzpraumlvalenz
Prognose Demenzerkrankungen 2025
Praumlvalenz(per 100000)
Anstieg in (bis 2025)
Quelle Demenz Report Berlin-Institut 2011
Potential for dementia prevention
Norton et al Lancet 2014
13
1914
8
5 3
2
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Hallauer 2001
2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050
Age (years)
90+ 85-90 80-85 75-80 70-75 65-70
Patie
nts
in 1
000
2500
2000
1500
1000
500
0
Prognose der Demenzpraumlvalenz
Prognose Demenzerkrankungen 2025
Praumlvalenz(per 100000)
Anstieg in (bis 2025)
Quelle Demenz Report Berlin-Institut 2011
Potential for dementia prevention
Norton et al Lancet 2014
13
1914
8
5 3
2
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Prognose Demenzerkrankungen 2025
Praumlvalenz(per 100000)
Anstieg in (bis 2025)
Quelle Demenz Report Berlin-Institut 2011
Potential for dementia prevention
Norton et al Lancet 2014
13
1914
8
5 3
2
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Potential for dementia prevention
Norton et al Lancet 2014
13
1914
8
5 3
2
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Primary prevention by improving life-style
Sample N=5205 gt 60 years
Satizabal et al NEJM 2016
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Success of primary prevention
Satizabal et al NEJM 2016
blood pressure
education
strokeheart attack
Satizabal et al NEJM 2016
overweightdiabetes typ2
smokingnicotin
non-degenerative dementia
degenerative dementia
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
(Neurodegenerative) diseases leading to dementia
556
156
200
33
4411
Alzheimer dementiaParkinson
dementia
Fronto-temporaldementia
otherdementia
Vasculardementia
Mixed Dementia
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
AD | |
Mixed | |
VD | |
PD | |
other | |
undetermined |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Akyildiz Nursel | 06-Apr-52 | 11-Aug-08 | 56 | 4592 | 16608 | ||||||||||||||
Baumlthge Annemarie | 16-Sep-29 | 29-Jul-08 | 78 | 4588 | 1602008 | ||||||||||||||
Brandies Harry | 20-Jan-24 | 18-Nov-08 | 84 | 4520 | 23308 | ||||||||||||||
Groehn Ernst | 21-Oct-36 | 18-Aug-08 | 71 | 4578 | 17608 | ||||||||||||||
Hagel Charlotte | 09-Jan-21 | 19-Aug-08 | 87 | 4576 | 17808 | ||||||||||||||
Hanke Dietmar | 29-Mar-28 | 14-Oct-08 | 80 | 4523 | 2062008 | ||||||||||||||
Husen Herrmann | 09-Mar-56 | 30-Oct-08 | 52 | 4534 | 2182008 | ||||||||||||||
Joachim Rosemarie | 14-Jul-40 | 12-Aug-08 | 68 | 4597 | 17208 | ||||||||||||||
Kalkan Binali | 01-Jan-51 | 12-Nov-08 | 57 | 4517 | 22708 | ||||||||||||||
Kreutz Eva | 21-Jul-37 | 16-Sep-08 | 71 | 4562 | 1902008 | ||||||||||||||
Kriehn Klaus-Peter | 24-Aug-38 | 08-Sep-08 | 70 | 4573 | 18608 | ||||||||||||||
Kwiecinski Erich | 30-Oct-32 | 21-Oct-08 | 78 | 4531 | 21508 | ||||||||||||||
Lenz Egon | 21-Jan-28 | 11-Jun-08 | 80 | 4632 | 11508 | ||||||||||||||
Plaumlhn Gisela | 05-Jan-34 | 17-Dec-08 | 74 | 4551 | 24408 | ||||||||||||||
Ranft Lore | 22-Mar-24 | 25-Jun-08 | 84 | 4617 | 13208 | ||||||||||||||
Roumlmhildt Renate | 20-Jun-39 | 27-May-08 | 68 | 4647 | 9908 | ||||||||||||||
Swiatek Barbara | 15-Nov-49 | 19-May-08 | 58 | 4651 | 9408 | ||||||||||||||
Thiele Kurt | 07-Aug-29 | 22-Dec-08 | 79 | 4548 | 24708 | ||||||||||||||
Vahedi Minoush | 13-Nov-70 | 09-Jun-08 | 37 | 4635 | 11208 | ||||||||||||||
Vangermain Hildegard | 17-Jan-36 | 11-Jun-08 | 72 | 4633 | 11408 | ||||||||||||||
Westphal Heidrun | 23-May-40 | 11-Aug-08 | 68 | 4595 | 17008 | ||||||||||||||
Wlosniewski Jutta | 03-Aug-55 | 19-May-08 | 51 | 4652 | 9308 | ||||||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | 23808 | |||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | 6808 | |||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | 1308 | |||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | 5308 | |||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | 608 | |||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | 8008 | |||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | 8608 | |||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | 7508 | |||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | 23108 | |||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | 24008 | |||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | 12908 | |||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | 10208 | |||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | 18808 | |||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | 7308 | |||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | 4908 | |||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | 8808 | |||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | 14908 | |||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | 18708 | |||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | 1008 | |||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | 6008 | |||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | 4008 | |||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | 14208 | |||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | 19508 | |||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | 14808 | |||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | 12608 | |||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | 19808 | |||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | 1622008 | |||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | 6508 | |||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | 25008 | |||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | 17408 | |||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | 13408 | ||||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | 4808 | |||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | 5008 | |||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | 4508 | |||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | 22908 | |||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | 17308 | |||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | 22808 | |||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | 9108 | |||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | 712008 | |||||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hannemann Horst | leichte Demenz | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | |||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 | ||||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 | |||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
MD wo cogDys | |
MD w cogDys | |
subMemDef | |
MCI | |
Dementia | |
other |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
210 | 90 | ||||||||||||||||||||||
40 | 190476190476 | MD wo cogDys | 190476190476 | 50 | AD | 555555555556 | |||||||||||||||||
11 | 52380952381 | MD w cogDys | 52380952381 | 18 | Mixed | 20 | |||||||||||||||||
43 | 204761904762 | subMemDef | 204761904762 | 3 | VD | 33333333333 | |||||||||||||||||
22 | 104761904762 | MCI | 104761904762 | 1 | PD | 11111111111 | |||||||||||||||||
90 | 428571428571 | Dementia | 428571428571 | 4 | other | 44444444444 | |||||||||||||||||
4 | 19047619048 | other | 19047619048 | 14 | undetermined | 155555555556 | |||||||||||||||||
Patienten | 232 | ||||||||||||||||||||||
(noch) ohne Diagnose | 22 | 95 | |||||||||||||||||||||
Depression | 40 | 172 | |||||||||||||||||||||
kognitive Stoumlrung bei Depression | 11 | 47 | |||||||||||||||||||||
subjektive Gedaumlchtnisstoumlrung | 43 | 185 | |||||||||||||||||||||
MCI | 22 | 95 | |||||||||||||||||||||
Demenz | 90 | 388 | Demenz | 90 | Demenz | 90 | |||||||||||||||||
unklar | 4 | 17 | leicht | 65 | 722 | Alzheimer | 50 | 556 | |||||||||||||||
mittelschwer | 15 | 167 | Mischdemenz | 18 | 200 | ||||||||||||||||||
schwer | 1 | 11 | Vaskulaumlr | 3 | 33 | ||||||||||||||||||
ohne Angabe | 9 | 100 | Parkinson | 1 | 11 | ||||||||||||||||||
100 | Epilepsie | 1 | 11 | ||||||||||||||||||||
unklar | 15 | 167 | |||||||||||||||||||||
ohne Angabe | 2 | 22 | |||||||||||||||||||||
100 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||
El-Khatib Mohamed | Depression | 01-Jan-37 | 25-Nov-08 | 71 | 4599 | ||||||||||||
Krickel Andreas | Depression | 27-Mar-54 | 17-Mar-08 | 53 | 4675 | ||||||||||||
Liebl Tatjana | Depression | 12-Sep-66 | 22-Jan-08 | 41 | 4720 | ||||||||||||
Boumlhme Evelin-Maria | Depression rez | 20-Jul-48 | 20-Feb-08 | 59 | 4690 | ||||||||||||
Ruhfaszlig Wilma | Depression rez | 30-Jun-60 | 15-Jan-08 | 47 | 4725 | ||||||||||||
Alkan Cevahir | Depression leicht | 01-Jan-40 | 15-Apr-08 | 68 | 4665 | ||||||||||||
Hauschild Christa | Depression leicht | 06-Jan-31 | 28-Apr-08 | 77 | 4659 | ||||||||||||
Janicki Dana | Depression leicht | 10-Mar-58 | 02-Apr-08 | 49 | 4669 | ||||||||||||
Kirchner Hanns | Depression leicht | 16-Nov-34 | 17-Nov-08 | 74 | 4537 | ||||||||||||
Kostka Heidi | Depression leicht | 27-Nov-62 | 08-Dec-08 | 46 | 4601 | ||||||||||||
Marquardt Horst | Depression leicht | 22-Aug-35 | 24-Jun-08 | 72 | 4620 | ||||||||||||
Matthes Sylvia | Depression leicht | 27-Jan-53 | 28-May-08 | 55 | 4644 | ||||||||||||
Matys Marianne | Depression leicht | 19-May-34 | 07-Mar-95 | 60 | 4575 | ||||||||||||
Muumlller Birgit | Depression leicht | 08-Jul-67 | 01-Apr-08 | 40 | 4671 | ||||||||||||
Nahme Eckart | Depression leicht | 05-Jul-39 | 19-Feb-08 | 68 | 4694 | ||||||||||||
Neumann Christa | Depression leicht | 29-May-37 | 06-May-08 | 70 | 4657 | ||||||||||||
Raumlthel Heike | Depression leicht | 01-Jul-63 | 10-Jul-08 | 45 | 4353 | ||||||||||||
Rau Edeltraut | Depression leicht | 17-May-39 | 10-Sep-08 | 69 | 4566 | ||||||||||||
Reddies Guumlnter | Depression leicht | 18-Jul-44 | 22-Jan-08 | 63 | 4730 | ||||||||||||
Schaepe Hans | Depression leicht | 10-May-28 | 03-Mar-08 | 79 | 4683 | ||||||||||||
Thrun Maria | Depression leicht | 06-Feb-44 | 12-Feb-08 | 64 | 4701 | ||||||||||||
Trampedach Marianne | Depression leicht | 23-Nov-41 | 02-Jul-08 | 66 | 4610 | ||||||||||||
Wilhelm Helmut | Depression leicht | 07-Jan-56 | 22-Sep-08 | 52 | 4561 | ||||||||||||
Bemben Christa | Depression leicht - mittelschwer | 21-Dec-49 | 09-Jul-08 | 58 | 4227 | ||||||||||||
Haake Baumlrbe | Depression leicht - mittelschwer | 12-Sep-39 | 19-Jun-08 | 68 | 4621 | ||||||||||||
Lindenberg Konrad | Depression leicht - mittelschwer rez | 01-Jan-50 | 26-Jul-07 | 57 | 4558 | ||||||||||||
Malcher Regina | Depression leicht | 02-Mar-53 | 05-Aug-08 | 56 | 4590 | ||||||||||||
Bolduan Ingrid | Depression mittelschwer | 26-Nov-43 | 10-Mar-08 | 64 | 4678 | ||||||||||||
Hundt Margit | Depression mittelschwer | 25-Jul-29 | 22-Dec-08 | 79 | 4545 | ||||||||||||
Kurtar Nadide | Depression mittelschwer | 21-May-42 | 14-Aug-08 | 66 | 4580 | ||||||||||||
Pankratz-Schuhmann Christel | Depression mittelschwer | Va chronisch neurodegenerative Erkrankung | 21-Oct-34 | 26-Jun-08 | 73 | 4614 | |||||||||||
Stukowske Marlene | Depression mittelschwer | 14-Feb-45 | 18-Feb-08 | 63 | 4695 | ||||||||||||
Ulbrich Wolfgang | Depression mittelschwer | 06-Sep-54 | 20-Feb-08 | 53 | 4693 | ||||||||||||
Winkelmann Doris | Depression mittelschwer | 20-Nov-55 | 18-Feb-08 | 52 | 4698 | ||||||||||||
Zurborn Bernd-Dietrich | Depression mittelschwer | 18-Nov-48 | 13-Nov-08 | 59 | 4518 | ||||||||||||
Stolte Waltraud | Depression mittelschwer rez | 02-May-25 | 13-Aug-08 | 83 | 4598 | ||||||||||||
Tas- Kockazi Zoehre | Depression mittelschwer rez | 05-Aug-60 | 12-Nov-08 | 48 | 4516 | ||||||||||||
Wanjelik Ursula | Depression mittelschwer rez | 25-Jan-57 | 13-May-08 | 51 | 4654 | ||||||||||||
Yildiz Zadegul | Depression mittelschwer rez | 11-Feb-49 | 26-Mar-08 | 59 | 4538 | ||||||||||||
Muumlller Konstantin | Va Depression leicht | 14-Jul-71 | 11-Aug-08 | 37 | 4593 | 1672008 | |||||||||||
40 | |||||||||||||||||
Kira Ethem | kognitive Stoumlrung bei chron Depression | 8 | 01-Dec-48 | 25-Feb-08 | 59 | 4688 | 5508 | ||||||||||
Grund Ursula | kognitive Stoumlrung bei Depression | 8 | 17-Dec-35 | 20-Oct-08 | 72 | 4554 | 21208 | ||||||||||
Hornemann Ingrid | kognitive Stoumlrung bei Depression | 8 | 16-Jul-52 | 29-May-08 | 55 | 4642 | 10408 | ||||||||||
Leska Erich | kognitive Stoumlrung bei Depression | 8 | 06-May-31 | 20-Feb-08 | 76 | 4691 | 5208 | ||||||||||
Lobig Jens | kognitive Stoumlrung bei Depression | 8 | 14-Aug-63 | 29-May-08 | 44 | 4643 | 10308 | ||||||||||
Seemann Evelyn | kognitive Stoumlrung bei Depression | 8 | 12-Nov-48 | 29-Jan-08 | 59 | 4714 | 2208 | ||||||||||
Zemlin Hanna | kognitive Stoumlrung bei Depression | 8 | 11-Feb-34 | 23-Jan-08 | 73 | 4539 | 152008 | ||||||||||
Lambrecht Rosemarie | kognitive Stoumlrung bei Depression und unterdurchschnittlicher Intelligenz | 8 | 11-Sep-60 | 26-May-08 | 47 | 4648 | 9808 | ||||||||||
Dierking Stefan | kognitive Stoumlrung bei Depression mittelschwer | 8 | 03-Feb-62 | 17-Jul-08 | 46 | 4246 | 15308 | ||||||||||
Scheuer Eva | kognitive Stoumlrung bei Depression | 8 | 02-Sep-35 | 05-Aug-08 | 72 | 4589 | 1632008 | ||||||||||
Rast Monika | kognitive Stoumlrung bei schwerer Depression | 8 | 18-Jun-51 | 05-Jun-08 | 57 | 4637 | 11008 | ||||||||||
11 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Wacker Birgit | subj Gedaumlchtnisbeschwerden | 1 | 08-Aug-53 | 08-Jan-08 | 57 | 4732 | 308 | ||||||||||||
Ahne Herbert | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Mar-36 | 12-Mar-08 | 72 | 4668 | 7708 | ||||||||||||
Berg Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jun-37 | 23-Apr-08 | 70 | 4661 | 8408 | ||||||||||||
Criee Barbara | subjektive Gedaumlchtnisbeschwerden | 1 | 20-May-56 | 30-Jun-08 | 52 | 4607 | 13908 | ||||||||||||
Domroumlse Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jul-47 | 12-Mar-08 | 60 | 4676 | 6708 | ||||||||||||
Dr Arnold Hanfried | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-35 | 27-Feb-08 | 73 | 4684 | 5908 | ||||||||||||
Engelien Gabriele | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Sep-40 | 11-Feb-08 | 67 | 4703 | 3708 | ||||||||||||
Fichte Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Apr-44 | 02-Jul-08 | 64 | 4611 | 14308 | ||||||||||||
Fisch Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-36 | 16-Jun-08 | 72 | 4626 | 12108 | ||||||||||||
Fuchs Wilfried | subjektive Gedaumlchtnisbeschwerden | 1 | 18-Mar-53 | 10-Mar-08 | 54 | 4680 | 6308 | ||||||||||||
Glawe Bernhard | subjektive Gedaumlchtnisbeschwerden | 1 | 21-May-27 | 14-May-08 | 80 | 4653 | 9208 | ||||||||||||
Guss Siegfried | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Jun-32 | 02-Jul-08 | 76 | 4522 | 1522008 | ||||||||||||
Hirtzel Bernd | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-50 | 22-Sep-08 | 58 | 4559 | 1972008 | ||||||||||||
Hutsch Veronika | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Dec-36 | 28-May-08 | 71 | 4645 | 10108 | ||||||||||||
Imbault Ilse | Subjektive Gedaumlchtnisbeschwerden | 1 | 11-Mar-42 | 12-Aug-08 | 66 | 4596 | 17108 | ||||||||||||
Kargarotos Nicolas | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Apr-41 | 21-Apr-08 | 67 | 4662 | 8308 | ||||||||||||
Kliche Matthias | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Dec-54 | 29-Sep-08 | 53 | 4557 | 20008 | ||||||||||||
Krause Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Feb-36 | 15-Jul-08 | 72 | 4536 | 15008 | ||||||||||||
Kruumlger Edith | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Mar-22 | 23-Apr-08 | 86 | 4660 | 8508 | ||||||||||||
Kutscher Ingrid | subjektive Gedaumlchtnisbeschwerden | 1 | 23-Apr-47 | 11-Dec-08 | 61 | 4544 | 24208 | ||||||||||||
Lange Detlev | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Jan-58 | 23-Oct-08 | 50 | 4533 | 21708 | ||||||||||||
Petrich Edda | subjektive Gedaumlchtnisbeschwerden | 1 | 06-Jul-41 | 12-Feb-08 | 66 | 4702 | 3908 | ||||||||||||
Rinkleff Klaus | subjektive Gedaumlchtnisbeschwerden | 1 | 02-Dec-38 | 17-Sep-08 | 69 | 4563 | 19308 | ||||||||||||
Rudolph Dieter | subjektive Gedaumlchtnisbeschwerden | 1 | 01-May-39 | 19-Mar-08 | 68 | 4673 | 7008 | ||||||||||||
Ruiz Pena Hildegard | subjektive Gedaumlchtnisbeschwerden | 1 | 26-Nov-40 | 18-Jun-08 | 68 | 4622 | 1252008 | ||||||||||||
Schefter Lothar | subjektive Gedaumlchtnisbeschwerden | 1 | 24-May-39 | 27-Feb-08 | 68 | 4685 | 5808 | ||||||||||||
Schmidt-Reichel Kriemhild | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Oct-38 | 30-Jun-08 | 69 | 4608 | 14008 | ||||||||||||
Schorratz Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 15-Jul-38 | 12-Feb-08 | 69 | 4700 | 4108 | ||||||||||||
Schreck Karola | subjektive Gedaumlchtnisbeschwerden | 1 | 10-Jul-59 | 04-Jun-08 | 48 | 4639 | 10808 | ||||||||||||
Schroumlter Inge | subjektive Gedaumlchtnisbeschwerden | 1 | 21-Mar-37 | 12-Jun-08 | 71 | 4630 | 11708 | ||||||||||||
Schwade Wolfgang | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Nov-41 | 13-Nov-08 | 67 | 4519 | 23008 | ||||||||||||
Schwarz Reent | subjektive Gedaumlchtnisbeschwerden | 1 | 27-Jun-43 | 19-Aug-04 | 61 | 4570 | 1962008 | ||||||||||||
Steigerwald Angela | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Feb-54 | 07-May-08 | 54 | 4656 | 8908 | ||||||||||||
Stoldt Joachim | subjektive Gedaumlchtnisbeschwerden | 1 | 07-Feb-53 | 11-Mar-08 | 55 | 4677 | 6608 | ||||||||||||
Thiele Heinz-Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 09-Jan-50 | 18-Feb-08 | 58 | 4696 | 4708 | ||||||||||||
Voigt Sylvelin | subjektive Gedaumlchtnisbeschwerden | 1 | 22-Aug-37 | 05-Feb-08 | 70 | 4707 | 3108 | ||||||||||||
Wambutt Rolf | subjektive Gedaumlchtnisbeschwerden | 1 | 17-Aug-55 | 10-Nov-08 | 53 | 4513 | 22308 | ||||||||||||
Waschow Juumlrgen | subjektive Gedaumlchtnisbeschwerden | 1 | 20-Oct-41 | 06-Oct-08 | 66 | 4556 | 20508 | ||||||||||||
Wichmann Renate | subjektive Gedaumlchtnisbeschwerden | 1 | 29-Oct-46 | 27-May-08 | 61 | 4646 | 10008 | ||||||||||||
Kruumlger Fritz | subjektive Gedaumlchtnisbeschwerden DD MCI | 1 | 13-Mar-31 | 21-Apr-08 | 77 | 4663 | 8208 | ||||||||||||
Bugge Harry | subjektive Gedaumlchtnisbeschwerden | 1 | 19-Aug-24 | 06-Feb-08 | 83 | 4743 | 3508 1309 | ||||||||||||
Hannusch Reinhard | subjektive Gedaumlchtnisstoumlrung | 1 | 11-Jan-48 | 07-Jan-08 | 59 | 4728 | 108 | ||||||||||||
Franke Wolfgang | subjektive Gedaumlchtnisstoumlrung | 1 | 17-Jun-47 | 05-Feb-08 | 60 | 4706 | 3208 | ||||||||||||
43 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | |||||||||||
Uhlig Gretel | amnestic MCI | 2 | 05-May-39 | 05-Feb-08 | 69 | 4784 | 3008 | ||||||||||||
Barnetz Rosemarie | MCI | 30-Oct-35 | 01-Sep-08 | 72 | 4571 | 18108 | |||||||||||||
Berg Monika | MCI | 27-Jul-48 | 05-Mar-08 | 59 | 4682 | 6108 | |||||||||||||
Berndorff Karl | MCI | vaskulaumlr | 3 | 28-Apr-31 | 04-Feb-08 | 76 | 4708 | 2908 | |||||||||||
Dr Schiementz Wolfgang | MCI | frontoparietal | 8 | 18-Nov-51 | 15-Sep-08 | 56 | 4574 | 18908 | |||||||||||
Guss Ingeborg | MCI | 23-Sep-35 | 05-Nov-08 | 73 | 4512 | 22208 | |||||||||||||
Handke Horst | MCI | unklar | 9 | 12-Nov-34 | 04-Aug-08 | 73 | 4587 | 1612008 | |||||||||||
Hartmann Manfred | MCI | 24-Jun-48 | 20-Oct-08 | 60 | 4553 | 21408 | |||||||||||||
Hartrampf Guumlnter | MCI | vaskulaumlr | 3 | 20-Mar-49 | 11-Feb-08 | 58 | 4704 | 3808 | |||||||||||
Hoffmann Frank | MCI | unklar | 9 | 18-Jul-39 | 13-May-08 | 69 | 4655 | 9008 | |||||||||||
Merkel Juumlrgen | MCI | 24-Mar-61 | 16-Jan-08 | 46 | 4731 | 808 | |||||||||||||
Nuumlrnberg Fred | MCI | vaskulaumlr | 3 | 27-Jul-32 | 19-Jun-08 | 75 | 4627 | 12708 | |||||||||||
Paumltzold Juumlrgen | MCI | 25-Jul-39 | 25-Nov-08 | 69 | 4600 | 23908 | |||||||||||||
Prof Bruumlckner Helga | MCI | 15-Mar-35 | 04-Nov-08 | 73 | 4535 | 21908 | |||||||||||||
Radde Jutta | MCI | 28-Jul-44 | 04-Nov-08 | 64 | 4511 | 22008 | |||||||||||||
Schust Gerhard | MCI | vaskulaumlr | 3 | 18-May-22 | 21-Jul-08 | 86 | 4269 | 15408 | |||||||||||
Schiffer Wolfgang | MCI (DDsiehe Notiz) | 09-Aug-38 | 22-Jan-08 | 69 | 4721 | 122008 | |||||||||||||
Ruumlbesame Klaus | MCI bei Va beginnende chron neurogenerative Erkrankung | 10-May-37 | 04-Jul-08 | 70 | 4748 | 14508 9209 | |||||||||||||
Spiegelberg Werner | MCI Va Schizoaffektive Stoumlrung mit ggw leichtem depressiven Syndrom | unklar | 9 | 24-Jun-40 | 28-Jul-08 | 68 | 4584 | 15908 | |||||||||||
Braumann Bernhard | multidomain MCI | 4 | 27-Dec-47 | 22-Oct-08 | 61 | 4532 | 21608 | ||||||||||||
Firzlaff Carla | multidomain MCI | 4 | vaskulaumlre Enzephalopathie | 3 | 19-Feb-24 | 03-Jul-08 | 84 | 4606 | 14408 | ||||||||||
Knoch Karin | multidomain MCI | 4 | 17-Sep-40 | 23-Jul-08 | 67 | 4586 | 15708 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Anemuumlller Gertrud | Demenz | Alzheimer | 1 | 31-Oct-22 | 01-Jul-08 | 85 | 4609 | 14108 | |||||||||||
Foerder Hans-Karl | Demenz | Alzheimer | 1 | 28-Aug-21 | 15-Apr-08 | 86 | 4666 | 7908 | |||||||||||
Haneberg Birgit | Demenz | Alzheimer | 1 | 29-Oct-45 | 02-Apr-08 | 62 | 4670 | 7408 | |||||||||||
Streichan Edeltraud | leichte - mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Feb-30 | 18-Jun-08 | 78 | 4623 | 1242008 | ||||||||||
Blanke Heidemarie | leichte Demenz | 5 | Alzheimer | 1 | 25-Oct-41 | 24-Sep-08 | 66 | 4603 | 19908 | ||||||||||
Breyer Ingeborg | leichte Demenz | 5 | Alzheimer | 1 | 06-Jun-31 | 25-Jun-08 | 77 | 4618 | 13108 | ||||||||||
Collatz Klaus | leichte Demenz | 5 | Alzheimer | 1 | 24-Apr-51 | 18-Dec-08 | 57 | 4552 | 24508 | ||||||||||
Digulla Peter | leichte Demenz | 5 | Alzheimer | 1 | 30-May-38 | 20-Oct-08 | 70 | 4555 | 21108 | ||||||||||
Fell Heinz | leichte Demenz | 5 | Alzheimer | 1 | 20-Apr-26 | 11-Aug-08 | 82 | 4594 | 16808 | ||||||||||
Fiorentini Reginaldo | leichte Demenz | 5 | Alzheimer | 1 | 15-Apr-38 | 10-Nov-08 | 69 | 4515 | 22508 | ||||||||||
Fleischer Maria | leichte Demenz | 5 | Alzheimer | 1 | 11-Jul-31 | 04-Feb-08 | 76 | 4709 | 2708 | ||||||||||
Gast Herta | leichte Demenz | 5 | Alzheimer | 1 | 18-Nov-20 | 21-May-08 | 87 | 4649 | 9608 | ||||||||||
Jaumlhniche Gisela | leichte Demenz | 5 | Alzheimer | 1 | 16-Nov-35 | 03-Sep-08 | 72 | 4565 | 18208 | ||||||||||
Koumlhler Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 04-Jan-24 | 20-Feb-08 | 84 | 4692 | 5108 | ||||||||||
Kramer Erna | leichte Demenz | 5 | Alzheimer | 1 | 07-Nov-31 | 03-Jun-08 | 77 | 4641 | 10608 | ||||||||||
Kremser Manfred | leichte Demenz | 5 | Alzheimer | 1 | 02-May-36 | 26-Mar-08 | 71 | 4672 | 7208 | ||||||||||
Krickstadt Helga | leichte Demenz | 5 | Alzheimer | 1 | 16-Apr-35 | 25-Nov-08 | 73 | 4543 | 23708 | ||||||||||
Krumnow Rosemarie | leichte Demenz | 5 | Alzheimer | 1 | 12-Jul-37 | 18-Aug-08 | 71 | 4579 | 17508 | ||||||||||
Ladebusch Gerda | leichte Demenz | 5 | Alzheimer | 1 | 15-Aug-25 | 26-Jun-08 | 82 | 4510 | 13608 | ||||||||||
Laue Ulrich | leichte Demenz | 5 | Alzheimer | 1 | 07-Apr-40 | 15-Jul-08 | 68 | 4243 | 15108 | ||||||||||
Meyer Margarete | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-31 | 30-Sep-08 | 77 | 4528 | 2022008 | ||||||||||
Muumlller Horst | leichte Demenz | 5 | Alzheimer | 1 | 27-Nov-39 | 18-Nov-08 | 68 | 4615 | 23208 | ||||||||||
Muranski Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 09-Mar-32 | 29-Sep-08 | 76 | 4527 | 2012008 | ||||||||||
Papke Hildegard | leichte Demenz | 5 | Alzheimer | 1 | 17-Aug-22 | 16-Dec-08 | 86 | 4550 | 24308 | ||||||||||
Pausch Irmgard | leichte Demenz | 5 | Alzheimer | 1 | 12-Mar-26 | 12-Feb-08 | 81 | 4699 | 4208 | ||||||||||
Proumlh Leonie | leichte Demenz | 5 | Alzheimer | 1 | 21-Sep-21 | 23-Jan-08 | 86 | 4719 | 1408 | ||||||||||
Reinsch Yong-Hui | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-48 | 05-May-08 | 59 | 4658 | 8708 | ||||||||||
Rothfuss Dina-Luise | leichte Demenz | 5 | Alzheimer | 1 | 12-Dec-32 | 25-Jun-08 | 75 | 4619 | 13008 | ||||||||||
Schmidt-Burbach Renate | leichte Demenz | 5 | Alzheimer | 1 | 10-Jan-43 | 21-Jul-08 | 65 | 4211 | 15508 | ||||||||||
Schmidtchen Ursula | leichte Demenz | 5 | Alzheimer | 1 | 09-May-36 | 12-Jun-08 | 72 | 4631 | 11608 | ||||||||||
Schmidt-Faber Inge | leichte Demenz | 5 | Alzheimer | 1 | 08-Feb-27 | 29-Jan-08 | 80 | 4715 | 2008 | ||||||||||
Schulz Edith | leichte Demenz | 5 | Alzheimer | 1 | 02-Dec-41 | 20-May-08 | 66 | 4650 | 9508 | ||||||||||
Sonnenberg Alfred | leichte Demenz | 5 | Alzheimer | 1 | 09-Jan-33 | 18-Dec-08 | 75 | 4549 | 24608 | ||||||||||
Stephan Gerhard | leichte Demenz | 5 | Alzheimer | 1 | 29-Jan-22 | 01-Oct-08 | 86 | 4521 | 20308 | ||||||||||
Suumlnder Kurt | leichte Demenz | 5 | Alzheimer | 1 | 28-Jun-36 | 16-Sep-08 | 72 | 4604 | 19108 | ||||||||||
Timmermann Ernst | leichte Demenz | 5 | Alzheimer | 1 | 26-Nov-39 | 07-Aug-08 | 68 | 4297 | 1642008 | ||||||||||
von Lersner Heinrich | leichte Demenz | 5 | Alzheimer | 1 | 17-Jul-30 | 13-Jun-08 | 77 | 4629 | 11908 | ||||||||||
Zothner Joachim | leichte Demenz | 5 | Alzheimer | 1 | 26-Mar-25 | 14-Oct-08 | 83 | 4524 | 2072008 | ||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Mantke Ruth | leichte Demenz | 5 | Alzheimer | 1 | 28-Feb-31 | 17-Jun-08 | 77 | 4624 | 12308 | ||||||||||
Hannemann Horst | leichte Demenz | 5 | Alzheimer | 1 | 08-Jan-50 | 04-Feb-08 | 58 | 4747 | 2808 15809 | ||||||||||
Knoepffler Baumlrbel | Demenz | Mischtyp | 2 | 01-Jun-50 | 30-Jan-08 | 57 | 4710 | 2608 | |||||||||||
Weimann Ernst | leichte - mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Jan-24 | 24-Jul-08 | 84 | 4585 | 1582008 | ||||||||||
Auge Horst | leichte Demenz | 5 | Mischtyp | 2 | 17-Mar-38 | 03-Sep-08 | 70 | 4567 | 18308 | ||||||||||
Bruckert Heinz | leichte Demenz | 5 | Mischtyp | 2 | 07-Nov-20 | 09-Jan-08 | 87 | 4726 | 408 | ||||||||||
Daleszynski Kurt | leichte Demenz | 5 | Mischtyp | 2 | 31-Jan-27 | 05-Jun-08 | 81 | 4638 | 10908 | ||||||||||
Doumlring Edith | leichte Demenz | 5 | Mischtyp | 2 | 20-Jan-35 | 28-Jan-08 | 73 | 4717 | 1808 | ||||||||||
Drewnicki Richard | leichte Demenz | 5 | Mischtyp | 2 | 08-Oct-25 | 16-Oct-08 | 83 | 4526 | 21008 | ||||||||||
Froeschle Peter | leichte Demenz | 5 | Mischtyp | 2 | 15-Feb-25 | 05-Mar-08 | 83 | 4681 | 6208 | ||||||||||
Lehne Hannelore | leichte Demenz | 5 | Mischtyp | 2 | 16-Apr-34 | 17-Jun-08 | 74 | 4625 | 12208 | ||||||||||
Petersen Dr Frerk | leichte Demenz | 5 | Mischtyp | 2 | 29-Dec-33 | 10-Nov-08 | 74 | 4514 | 22408 | ||||||||||
Schoumlnwaumllder Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 30-Oct-33 | 07-Jan-08 | 74 | 4727 | 208 | ||||||||||
Schwarz Eva | leichte Demenz | 5 | Mischtyp | 2 | 24-Jan-34 | 20-Oct-08 | 74 | 4530 | 21308 | ||||||||||
Vollenscheer Guumlnter | leichte Demenz | 5 | Mischtyp | 2 | 23-Jan-29 | 24-Nov-08 | 79 | 4541 | 23508 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Duumlnkel Willy | leichte Demenz | 5 | Mischtyp | 2 | 24-May-28 | 26-Jun-08 | 80 | 4616 | 13308 | ||||||||||
Gutschow Klaus-Peter | leichte Demenz | 5 | vaskulaumlr | 3 | 13-May-50 | 30-Jan-08 | 57 | 4713 | 2308 | ||||||||||
Gaumlrtner Marianne | leichte Demenz | 5 | vaskulaumlr DD Mischdemenz | 3 | 10-Mar-39 | 10-Jun-08 | 69 | 4634 | 11308 | ||||||||||
Raddatz Hildegard | Demenz | vaskulaumlr | 3 | 17-Nov-21 | 26-Jun-08 | 86 | 4612 | 13708 | |||||||||||
Hesse Kristin | leichte Demenz | 5 | Morbus Parkinson | 6 | 24-May-34 | 10-Jul-08 | 74 | 4583 | 14708 | ||||||||||
Miersch Guumlnter | leichte Demenz | 5 | bei kryptogener fokaler Epilepsie | 8 | 28-Jul-36 | 14-Oct-08 | 72 | 4525 | 20808 | ||||||||||
Karlik Lelia | Demenz | unklar | 9 | 24-Feb-47 | 20-Feb-08 | 60 | 4689 | 5408 | |||||||||||
Muumlller Renate | Demenz | unklar | 9 | 25-Jan-44 | 25-Feb-08 | 64 | 4687 | 5608 | |||||||||||
Abraham Karl-Heinz | leichte Demenz | 5 | unklar | 9 | 19-Aug-35 | 14-Oct-08 | 73 | 4529 | 20908 | ||||||||||
Alkan Dursun | leichte Demenz | 5 | unklar | 9 | 15-Feb-39 | 15-Apr-08 | 69 | 4664 | 8108 | ||||||||||
Blietz Ursula | leichte Demenz | 5 | unklar | 9 | 18-Jul-36 | 30-Jan-08 | 71 | 4711 | 2508 | ||||||||||
Derz Vera | leichte Demenz | 5 | unklar | 9 | 26-Sep-33 | 07-Jul-08 | 74 | 4605 | 14608 | ||||||||||
Hackenberg Heinz | leichte Demenz | 5 | unklar | 9 | 20-Feb-34 | 06-Feb-08 | 73 | 4705 | 3408 | ||||||||||
Ritterling Monika | leichte Demenz | 5 | unklar | 9 | 09-Nov-40 | 18-Feb-08 | 67 | 4697 | 4608 | ||||||||||
Schwarz-Lemcke Renate | leichte Demenz | 5 | unklar | 9 | 03-May-37 | 10-Mar-08 | 70 | 4679 | 6408 | ||||||||||
Vosgerau Kurt | leichte Demenz | 5 | unklar | 9 | 03-Oct-20 | 16-Jun-08 | 87 | 4628 | 12008 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Tarnow Christel | leichte Demenz | 5 | unklar Va FTD DD Lewy-Body | 9 | 25-Jun-36 | 23-Jun-08 | 71 | 4723 | 12808 | ||||||||||
Reinhardt Rudolf | leichte Demenz | 5 | unklar Va neurodegenerative Genese | 9 | 17-Jul-39 | 26-Aug-08 | 69 | 4569 | 17908 | ||||||||||
Vogel Norbert | leichte - mittelschwere Demenz | 5 | unklar Vaalkoholtoxische Enzephalopathie | 9 | 30-Jul-44 | 05-Aug-08 | 64 | 4724 | 16908 | ||||||||||
Muumlller Margit | Demenz | 29-Nov-50 | 19-Aug-08 | 57 | 4577 | 17708 | |||||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Namen | Syndromdiagnose | code Syndrom | Aumltiologie | code Aumltiologie | geb | Datum der Erstvorstellung | Alter bei Erstvorstellung | id | Pat_code | ||||||||||
Harpe William | diskrete kognitive Minderleistung | vaskulaumlre Encephalopathie | 3 | 09-Jul-37 | 18-Mar-08 | 70 | 4674 | 6908 | |||||||||||
Steinert Gerda | kognitive Defizite im Kurzzeitgedaumlchtnis | Va chron neurodegenerative Erkrankung | 14-May-37 | 08-Sep-08 | 71 | 4568 | 18508 | ||||||||||||
Schumann Guido | Kognitive Stoumlrung | 19-Feb-69 | 26-Jun-08 | 47 | 4613 | 13508 | |||||||||||||
Nitsche Edith | unklar | 08-Apr-30 | 09-Jun-08 | 78 | 4636 | 11108 | |||||||||||||
Hinz Hildegard | mittelschwere - schwere Demenz | 6 | Alzheimer | 1 | 19-Nov-31 | 22-Dec-08 | 77 | 4546 | 24908 | ||||||||||
Berndt Inge | mittelschwere Demenz | 6 | Mischtyp | 2 | 06-Mar-25 | 30-Jan-08 | 82 | 4712 | 2408 | ||||||||||
Beyer Dorothea | mittelschwere Demenz | 6 | unklar | 9 | 21-Dec-36 | 28-Jan-08 | 71 | 4716 | 1908 | ||||||||||
Cebesoy Guelzen | mittelschwere Demenz | 6 | Alzheimer | 1 | 10-Feb-41 | 07-Aug-08 | 67 | 4591 | 16508 | ||||||||||
Daeumichen Heidi | mittelschwere Demenz | 6 | Alzheimer | 1 | 08-Mar-45 | 02-Oct-08 | 63 | 4602 | 20408 | ||||||||||
Dr Foerder Elisabeth | mittelschwere Demenz | 6 | Mischtyp | 2 | 08-Jul-25 | 15-Apr-08 | 82 | 4667 | 7808 | ||||||||||
Ekert Marlene | mittelschwere Demenz | 6 | Alzheimer | 1 | 07-Jan-36 | 21-Jan-08 | 72 | 4722 | 908 | ||||||||||
Fiedler Hartmut | mittelschwere Demenz | 6 | Alzheimer | 1 | 30-Dec-55 | 09-Dec-08 | 52 | 4540 | 24108 | ||||||||||
Kybart Angela | mittelschwere Demenz | 6 | Alzheimer | 1 | 23-Aug-37 | 23-Jan-08 | 70 | 4718 | 1708 | ||||||||||
Muumlller Adelheit | mittelschwere Demenz | 6 | unklar | 9 | 09-Apr-36 | 22-Dec-08 | 72 | 4547 | 24808 | ||||||||||
Muumlller Elfriede | mittelschwere Demenz | 6 | Alzheimer | 1 | 27-Dec-20 | 25-Feb-08 | 87 | 4686 | 5708 | ||||||||||
Reiff Hans-Joachim | mittelschwere Demenz | 6 | Alzheimer | 1 | 18-Jan-30 | 17-Sep-08 | 78 | 4560 | 1942008 | ||||||||||
Santasa Unjo | mittelschwere Demenz | 6 | Mischtyp | 2 | 15-Dec-34 | 21-Jul-08 | 73 | 4187 | 15608 | ||||||||||
Strehmel Talitha | mittelschwere Demenz | 6 | Alzheimer | 1 | 05-Jun-20 | 03-Jun-08 | 87 | 4640 | 10708 | ||||||||||
Wilk Erwin | mittelschwere Demenz | 6 | Mischtyp | 2 | 07-Feb-27 | 17-Sep-08 | 81 | 4564 | 1922008 | ||||||||||
Lucyga Gertrud | schwere Demenz | 7 | Alzheimer | 1 | 13-Oct-24 | 22-Jan-08 | 83 | 4729 | 1108 | ||||||||||
Speyer Annemarie | Va beginnendes dementielles Syndrom | 04-Jul-30 | 24-Nov-08 | 78 | 4542 | 23608 16409 |
Uumlber eine eigenartigen schweren Krankheitsprozess der Hirnrinde
Neurologisches Zentralblatt Leipzig 1906 25 1134
Alois Alzheimeranno 1911
Alois Alzheimer
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Neuropathologie der Alzheimer Erkrankung
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
BaptistsBeta-Amyloid-protein
Hardy and Selkoe Science 2002
TaoistsTa(o)u-protein
Science 2005
Stoumlrung des Amyloidstoffwechselsrarr Amyloidablagerungenrarr Inflammation rarrNeurofibrillaumlre Tangles
Stoumlrung des axonalen Transportes rarr Stoumlrung des Proteinmetabolismusrarr Amyloidablagerungen
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Topographische Organisation der neurofibrillaumlrenDegeneration bei AD (Braak amp Braak 1995)
Geordnetes und vorhersagbares Muster das anders ist als bei der AmyloidpathologieDieses Muster reflektiert den Grad der Myelinisierung von Neuronen
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Amyloidhypothesis of AD
AmyloidspeciesAβ-Peptide
1-40 amp 1-42
Amyloid-fibrilles
β Secretaseγ Secretase
APP
extracellular
intracellular
soluble oligomeres
MCIDementia
Neuroinflammation
Neuro-fibrillarbundl
Aβ1-40 hArrAβ1-42 dArr
Tau amp pTau uArr
Neuro-degeneration
β-Amyloid-Plaques
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
CSF Biomarker to predict AD
Buchhave et al Arch Gen Psychiatry 2012
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Aβ1-42 at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
p-TAU at baseline and progression to dementia
Buchhave et al Arch Gen Psychiatry 2012
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Amyloid is needed for enhanced tau pathology
He et al Nature Medicine 2017
AD-WT (15mo) AD-APP KI (15mo) AD-5x FAD (8mo)
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Biomarker-Modell der Alzheimererkrankung
Modified according to Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
PraumlklinischeAlzheimer Erkrankung
Klinische Alzheimer Erkrankung
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
(A Amyloid T Tau-Pathology N Neurodegeneration)
AT(N) System fuumlr die praumlklinische Diagnose
Jack et al Alzheimers Dement 2018
A+T-(N)-
A+T+(N)+
A+T-(N)+
A+T+(N)-
van Maurik et al Lancet Neurology 2019
Demographics model (N=2611)
Harrellacutes C (95 CI) = 062 (059 ndash 065)
Hippocampal model (N=2042)
Harrellacutes C (95 CI) = 067 (062 ndash 072)
CSF biomarkers model (N=1617)
Harrellacutes C (95 CI) = 072 (068 ndash 074)
ATN model (N=1264)
Harrellacutes C (95 CI) = 074 (071 ndash 076)
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
U N I V E R S I T Auml T S M E D I Z I N B E R L I N 21
Uumlbersicht Verfahren der Demenzdiagnostik
Bereich Tests
(praumlmorbide) Intelligenz Wortschatztest LPS Untertest 3
Screeningverfahren MMSE DemTect 7mS Uhrentest
Testbatterien CERAD-NP ADAS-cog SIB
Spezifische Gedaumlchtnistest FCSRT VLMT WMS logisches Gedaumlchtnis figurales Gedaumlchtnis im WMS-R und CERAD
Funktionsbeeintraumlchtigung ADCS-ADL Bayer-ADL DAD
Schweregradmessung CDR
Verhaltensauffaumllligkeiten und affektive Symptomatik
NPI GDS HAM-D MADRS Cornell-Skala
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Etablierte Biomarker in der Demenzdiagnostik
MRT-Volumetrie Glukose-PET Amyloid-PET
Aβ-Proteine(Aβ 1-401-42)
Tau-ProteinLiquor cerebrospinalis
(total- phospho-Tau)
Bild
gebe
nde
Verfa
hren
Fluumls
sige
Biom
arke
r
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Limitations (part 1) Serious adverse events
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Roche Elecsysreg
Cobas E Immunoassay Analyzer
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Saumlulen der Diagnostik
Psycho-metrie
Bild-gebung
Bio-marker
Praumldemenz-Diagnostik
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Peters Heuser 2005
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Methods to detect Alzheimeracutes continuum
CSF Biomarker
Amyloid PET Tau PET
Aβ-Protein(Aβ 1-401-42)
(total- phospho-Tau)
about 500euro per patient
4000-5000europer patient
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Drug development in Alzheimeracutes Disease
Alzheimer DiseaseDrug registrations since 2002
Sucess rates in drug development 2002 - 2013
Memantine
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Antidementia drugs incl OTC
71
8
GALANTAMINE3
RIVASTIGMINE
6DONEPEZIL
MEMANTINE11
14
+19
2013
117
2012
112
2011
111
2010
110
2006
90
2005
85
2004
75
2003
65
2002
41
2001
202000
398 341 306 282
-108
2013201220112010
Antidementia Drugs in Germany ()
32 | Antidementiva Ad-Board | Novartis Pharma | 11 Feb 2014 | Business Use Only
14
111
2011
1
2000
13
44
55
GALANTAMINE
RIVASTIGMINE
DONEPEZIL
100
2013
117
27
21
MEMANTINE38
2012
1213
29
21
38
112
25
38
2004
64
23
14
26
37
2003
58
19
13
26
42
2002
39
17
19
31
33
2001
20
11
39
50
21
26
39
2010
110
15
20
25
39
2009
100
15
19
24
42
2006
77
15
17
27
40
2005
73
21
15
Quelle IMS PharmaScope (Mio Zaumlhleinheiten)
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Overview Clinical trials in AD
Cummings et al 2017
Phase 1 17Phase 2 53Phase 23 6Phase 3 15Phase 4 7
Anti-Amyloid 28Anti-Tau 10Inflammation 13Neurotransmitter 14Other 37
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
AMPA
NMDA
Glutamat Ach
Ach-Receptor
Acetylcholinesterase
CholinesteraseInhibitor
Na+
Ca2+
Glia
Glia
Cholinergic NeuronGlutamatergicNeuron
Neuron 3
GlutamatUptake
AChE
AChE
AChE
Choline+ acetat
Choline+ acetat
Symptomatic treatment AChE-Inh + Memantine
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Randomized Controlled Trials Combi-trials
A Combination of two symptomatic Antidementia drugs AChE-Inh + Memantine Add-on treatment rarr Tariot et al 2004
rarr Porsteinsson et al 2008rarr Howard et al 2012
De novo treatment rarr Peters et al 2012 (MCI)rarr Peters et al 2015 (AD)
B Combination of symtomatic and(potentially) disease modifying compounds
rarr gt 30 ongoing Phase II-III
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
DCN COMBI trial Demographic data
Galantamine + Placebo (MONO)
Galantamine + Memantine (COMBI)
Mean plusmn SD Mean plusmn SD P-value
Age 726 plusmn 78 721 plusmn 85 0612
Gender (female) 684 589 0138
MMSE 226 plusmn 31 217 plusmn 32 0029
ADAS-cog 189 plusmn 66 202 plusmn 70 0165
ADCS-ADL 621 plusmn 129 621 plusmn 105 098
NPI 79 plusmn 97 57 plusmn 67 0067
CDR (sum) 48 plusmn 14 5 plusmn 15 0297
MADRS 68 plusmn 47 72 plusmn 54 0549
Peters et al AlzampDemTRCI 2015
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Study Week
-4
-3
-2
-1
0
1
2
3
4
AD
AS-
cog
11 M
ean
Cha
nge
From
Bas
elin
e
End Point(LOCF)
DCN COMBI trial ADAS-cog
baseline 16 weeks
26 weeks
52 weeks
-1
0
1
2
3
-2 Galantamin + Placebo (MONO)
Galantamin + Memantine (COMBI)
AD
AS-
cog
(Mea
n ch
ange
from
bas
elin
e)
End point (LOCF)
p=083
wor
seni
ngim
prov
emen
t
Peters et al AlzampDemTRCI 2015
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Prevention trials in Alzheimeracutes disease
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Depression und Demenzen M Alzheimer
Alzheimererkrankung bedingt Depression in Braak-Stadien 3-4
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Antidepressiva bei Altersdepression
Wahl richtet sich daher nach Neben- und Wechselwirkungspotential ndash dh sorgsam Komorbiditaumlten und Begleitmedikation pruumlfenHerz-Kreislauf-Erkrankungen Krankheiten des
Bewegungsapparats obstruktive Lungenerkrankungen und Diabetes
SSRIs aufgrund geringerer Nebenwirkungen erste WahlBesondere Vorsicht mit SSRI bei kardiologisch vorbelasteten
aumllteren Menschen (QT-Zeit beachten) Anticholinerge Substanzen vermeiden (z B Amitriptylin
Clomipramin Doxepin Imipramin Maprotilin)
PRISCUS-Liste und STARTSTOPP-Kriterien beachten
Vgl Heilmann KE et al Fortschr Neurol Psychiatr 2015
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Tri- und tetrazyklische Antidepressiva (Priscus-Liste)
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
SSRI und MAO-Inhibitoren (Priscus-Liste)
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
SNRI Mirtazapin Bupropion Agomelatin
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Antidepressiva bei Altersdepression Remission
Mallery et al BMC Geriatrics 2019
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Biomarker-Model of Alzheimeracutes Disease
Modifiziert nach Jack et al Lancet Neurol 2013
Aβ1-42 Protein darrAmyloid-Plaque uarrTau Protein uarrAtrophieKlinischeSymptome
Prim
ary
prev
entio
n
Seco
ndar
y pr
even
tion
Sym
ptom
atic
trea
tmen
t
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Passive ImmunizationbullAducanumab (Biogen) bdquoEngagedldquo Phase III bullSolanezumab (Eli Lilly) bdquoExpeditionldquo Ph III bullGantenerumab bdquoSCarlet Road and bdquoMarguerite RoADldquo Ph IIIIIbullCrenezumab (Roche) bdquoGN28525ldquo Ph IIbullBAN 2401 (EISAI) Ph II
Inhibition of βminusSecretasebullAZD3293 (Eli Lilly) bdquoAmaranthldquobullJNJ-54861911 (Janssen) PreventionbullCNP520 (Novartis) Prevention
Active ImmunizationbullCAD106 (Novartis) Prevention
Image courtesy of the National Institute on AgingNational Institutes of Health
Clinical trials ndash amyloid targeted strategies
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Salloway S et al Neurology 2009732061-2070
Bapineuzumab in Phase II
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Bapineuzumab in Phase III (APOE non-carrier)
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
ARIA-Hmicrohaemorraghes
ARIA-Evasogenic oedema
Safety ARIA-E und -H
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Angriffspunkte von Immuntherapien
Aβ Monomere
Aβ Oligomereund Fibrillen
AmyloidPlaques
AmyloidPrecursor Protein
TauPathologie
RO71057051ndash3
bullAnti-Tau mAb bullBindung an Tau im extrazellulaumlren Raum des Gehirn einschlieszliglich toxischem loumlslichem TaubullPhase II laumluft (TAURIEL Programm)
Crenezumab4ndash6
bull Humanisierter anti-β-Amyloid IgG4 mAb
bull Bindung an multiple Formen des β-Amyloid mit Praumlferenz fuumlr Oligomere
bull Phase III laumluft(CREAD Programm)
Gantenerumab7ndash9
bull Humaner anti-β-Amyloid IgG1 mAb
bull Bindung an aggregierte Formen des β-Amyloid (Oligomere und Plaques)
bull Phase III laumluft (GRADUATE Programm)
Ig = Immunglobulin mAb = monoklonaler AntikoumlrperGantenerumab wird in Zusammenarbeit mit MorphoSys AG entwickelt Crenezumab und RO7105705 werden in Zusammenarbeit mit AC Immune entwickelt1 Ayalon G et al Neurodegener Dis 2017 17 (Suppl 1) ADPD7-1394 2 Kopeikina K et al Transl Neurosci 2012 3223ndash233 3 Clinicaltrialsgov NCT03289143 4 Ultsch M et al Scientific Reports 2016 739374 5 Clinicaltrialsgov NCT02670083 6 Clinicaltrialsgov NCT03114657 7 Clinicaltrialsgov NCT03443973 8 Clinicaltrialsgov NCT03444870 9 Bohrmann B et al J Alzheimers Dis 2012 2849ndash69
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
J Sevigny et al Nature 537 50ndash56 (2016)
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Weitere Informationen zu Studien mit AducanumabPRIME Phase Ib-Study (NCT01677572)EMERGE Phase III-Study (NCT02484547)ENGAGE Phase III-Study(NCT02477800)
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Results (Part 1)Amyloid reduction Baseline and week 54
J Sevigny et al Nature 537 50ndash56 (2016)
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Primary endpoint of EMERGE (larger dataset)
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Secondary endpoints of EMERGE (larger dataset)
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Primary and secondary endpoints from ENGAGE
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Amyloid PET SUVR Longitudinal change
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
CSF phospho Tau
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
EMERGEENGAGE CDR-SB exposure to 10 mgkg
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker
Arda-Can CetindagPhilip Dahmen
Enise Irem EncisoyFriederike Fenski
Silka Dawn FreieslebenMarie Charlotte Heilmann
Dietmar HauserLinda Koppenhagen
Arne KlostermannKatja Lindner
Herlind MeggesLukas Preis
Christina RoumlschAnke Strauss
Collaborating Partners(National)Wolfgang Maier (Bonn)Johannes Kornhuber (Erlangen)Jens Wiltfang (Goumlttingen)Frank Jessen (Koumlln)Lutz Froumllich (Mannheim)Stefan Teipel (Rostock)Alfredo Ramirez (Bonn)Piotr Lewczuk (Erlangen)Alexander Drzega (Koumlln)(International)Eugeen van Mechelen Gerd Multhaup (Montreal)Pieter Jelle Visser (Maastricht)
Memory Clinic amp Dementia Prevention CenterDepartment of Psychiatry - CBF und Experimental Research Center - CBB
Funded by
Colaborating PartnersChariteacute amp MDC (BIH)Ralph BuchertFrank HeppnerHelmut KettenmannThoralf NiendorfJosef PrillerNikolaus RajewskyErich Wanker