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The Most Advanced Digital Pathology Image Analysis Solution
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Slide - 1
The Most Advanced Digital Pathology Image Analysis Solution
Definiens Tissue Studio™
Slide - 2
Definiens Tissue Studio™ overview
Enables simple, fast, and accurate ROI detection via the new Definiens Composer Technology™
Provides multi-parametric quantitation on a cell-by-cell basis
Handles heterogeneous tissue samples
Works with whole slides and TMAs
Handles images acquired from any source
Operates as a dedicated workstation or as a client server application
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Definiens Composer Technology™
What is it?
Definiens Composer Technology™ was developed to enable the user to easily teach the system how to identify regions of interest (ROIs).
How does it work?
Simply load up to 4 representative images, and use the “paintbrush tool” on a few representative ROIs in your images. Then click the “Learn” button.
How does this differ from other approaches?
Training the system with 4 representative images ensures a robust image analysis solution without over fitting.
Combines machine learning, pattern recognition and auto adaptive analysis algorithms based on Definiens eCognition Network Language ™.
Definiens Tissue Studio™ is faster and more flexible.
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ROI Detection and Cell by Cell Analysis across and within selected ROIs
Definiens Tissue Studio™ Workflow
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Load training images
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Define image analysis solution
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Load up to four different images:Detect tissue / Background / Segment images
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Definiens Composer Technology™:“Paint” on a few representative ROIs
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Definiens Composer Technology™:After painting a few ROIs, click the “Learn” button
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Definiens Composer Technology™:Computer has now been “trained”
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Definiens Composer Technology™:Merge “Object Primitives”
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Second Definiens Composer step:Re-classify Islets into “tumor” and “normal”
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Select ROIs in tumor islets
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ROIs at 20xParameters can be adjusted and previewed here
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Detect nuclei
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Batch Process:Analyze selected images
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Export multi-parametric quantitative features
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List of supported instruments
Hamamatsu: Nanozoomer
Zeiss: Mirax
Aperio: Scanscope
Applied Imaging: Ariol
TissueGnostics
Bacus WebSlide
DMetrix
Generic (tif, jpg, etc.)
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Summary
Deeper insights
Quantifies nuclear, membrane and cytoplasmic biomarkers on a cell-by-cell basis
Supports all standard IHC tissue stains (blue, brown and red), H&E and IF
Analyzes all slides and TMA images from all major image acquisition devices
Faster results
Identifies regions of interest automatically
Operates through a simple, intuitive user interface
Offers unlimited throughput with parallel batch processing
Better decisions
Delivers accurate and reproducible results
Enables multiparametric investigations to identify underlying correlations
Supports translational research through rapid iterative investigation of biomarkers
Slide - 20
Daniel R. Nicolson
Director, Global Accounts
484-678-9090
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