Upload
winfred-kelly
View
217
Download
0
Embed Size (px)
Citation preview
Decisions
Transcribe gene
Splice RNA
Destroy protein
..Or for the whole cell?
Think small, talk big.
Sydney Brenner
Cooperative Binding
lacZ
Regulated Recruitment
Stepwise
Evolvability
1.3
1.3
1.3
Synergy is easy
Evolvability
‘New’ genes
Evolvability
Specificity depends onconcentration or sequestration
The Price
1.16
1.16
SH2 (P-Tyr)
PTB (P-Tyr)
SH3 (Pro)
FHA (P-Thr)
PH (PIP3)
HTH
HLH
Zn Finger
Winged Helix
Homeodomain
Recruiting Domains
A promoter
…looks like a receptor