Deanna L. Russell12611 Pacific Avenue #202. Los Angeles, CA 90066 (513) 600-1909 deanna.lyn.russell@gmail.com

R E S E A R C H S C I E N T I S THighlights

Established scientist with 20+ years of professional experience in industry and academia

Expertise in molecular and cell biology, genetics and genomics

Early target discovery and validation for metabolic diseases and cancer experience

Capable people manager

Education

MS in Genetics and Cell Biology, Washington State University – Pullman, Washington

BS in Zoology , Ohio University – Athens, Ohio

Professional Experience

Agensys, Applied Molecular Biology Department – Santa Monica, CASr. Principal Associate, January 2011 to Present

Characterized gene expression and structure of novel therapeutic antibody targets Collaborated to functionally validate targets using RNAi technology Established Cell Bank of 400+ cancer cell line models Mentored junior group members Generated WPIs

Rutgers, The State University of NJ, Department of Nutritional Sciences – New Brunswick, NJLaboratory Researcher III/Lab Manager, August 2006 to April 2010

Studied lipid droplet associated proteins, perilipin and CGI-58 On-site expert in RNA isolation, cDNA synthesis, and qPCR Ensured regulatory compliance of laboratory and documented safety SOPS Directly supervised and trained undergraduate and graduate students

University of Cincinnati, Genome Research Institute, Obesity Research Center – Cincinnati, OHResearch Associate/Molecular Biology Lab Manager, July 2004 to May 2006

Profiled gene expression of targets involved with feeding behavior in the CNS Incorporated new techniques and evaluated new technologies Collaborated to write grants and proposals for research funding Managed the daily operations and budget of the molecular lab Directly supervised and trained technicians, graduate students and post-docs

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Myriad Genetics – Salt Lake City, UTPredisposition Gene Discovery GroupScientist I, April 1997 to June 2004

Line head of the mutation screening team that identified HOB1 as an obesity predisposition gene Validated HOB1 as an obesity/diabetes therapeutic target Characterized lead compounds targeting HOB1 using cell based assays Identified diabetes predisposition genes through association studies Directly supervised teams of 2-5 Research Associates Presented data internally and to external collaborators

Technical Competencies

RNA extraction, cDNA synthesisPCR, qPCR, ddPCRSequence analysisNorthern/Southern and Western analysiscDNA library construction/screeningSite-directed mutagenesisProtein purificationImmunoprecipitationBiochemical assays

In-situ hybridizationImmunohistochemistry

Immunofluorescence microscopy Cell cultureFlow cytometryTransfections/transductionsGeneration of stable linesInducible expression systemsRNAi (shRNA and siRNA)Cell-based assays

Association studiesLinkage analysis (MCSIM)Genotyping (STRs and SNPs)Haplotype and recombination analysis

Technology Tools

Excel, Prism, Vector NTI, GCG package, GDE, Sequencher, NCBI and ExPASY tools, Genome Browser, FACSExpress, FLowJo, Spotfire, CFX manager, PowerPoint

Professional Affiliations and Activities

Association of Women in ScienceAmerican Association for the Advancement of ScienceNY Academy of SciencesNSF Graduate Research Fellowship Program Panelist, 2014 and 2015

Continuing Education

Applied Immunology, UC San Diego Extension, 2012 Summer Session

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Publications

Sahu-Osen A, Montero-Moran G, Schittmayer M, Fritz K, Dinh A, Chang YF, McMahon D, Boeszoermenyl A, Cornaciau I, RUSSELL D, Oberer M, Carman GM, Birner-Gruenberger R, Brasaemle DL. (2015) CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization. J Lipid Research 56(1): 109-21.

Wang H, Hu L, Dalen K, Dorward H, Marcinkiewicz A, RUSSELL D, Gong D, Londos C, Yamaguchi T, Holm C, Rizzo MA, Brasaemle D, Sztalryd C. (2009) Activation of hormone-sensitive lipase requires two steps: protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J Biol Chem, 284: 32116-32125.

Stone S, Abkevich V, RUSSELL DL, Riley R, Timms K, Tran T, Trem D, Frank D, Jammulapati S, Neff CD, Iliev D, Gress R, He G, Frech GC, Adams TD, Skolnick MH, Lanchbury J, Gutin A, Hunt SC, and Shattuck D. (2006) Tbc1d1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum Mol Genet, 15(18): 2709-20.

Abkevich V, Camp NJ, Hensel CH, Neff CD, RUSSELL DL, Hughes DC, Plenk AM, Lowry MR, Richards RL, Carter C, Frech GC, Stone S, Rowe K, Chau CA, Cortado K, Hunt A, Luce K, O'Neil G, Poarch J, Potter J, Poulsen GH, Saxton H, Bernat-Sestak M, Thompson V, Gutin A, Skolnick MH, Shattuck D, Cannon-Albright L. (2003) Predisposition locus for major depression at chromosome 12q22-12q23.2. Am J Hum Genet, 73(6):1271-1281.

Stone S, Abkevich V, Hunt SC, Gutin A, RUSSELL DL, Neff CD, Riley R, Frech GC, Hensel CH, Jammulapati S, Potter J, Sexton D, Tran T, Gibbs D, Iliev D, Gress R, Bloomquist B, Amatruda J, Rae PM, Adams TD, Skolnick MH, Shattuck D. (2002) A major predisposition locus for severe obesity, at 4p15-p14. Am J Hum Genet, 70(6):1459-68.

Hunt SC, Abkevich V, Hensel CH, Gutin A, Neff CD, RUSSELL DL, Tran T, Hong X, Jammulapati S, Riley R, Weaver-Feldhaus J, Macalma T, Richards MM, Gress R, Francis M, Thomas A, Frech GC, Adams TD, Shattuck D, Stone S. (2001) Linkage of body mass index to chromosome 20 in Utah pedigrees. Hum Genet, 109(3):279-85.

Berberich SJ, RUSSELL DL. (1997) Tumor suppressor genes, p53. Encyclopedia of Human Biology, Second Edition, Volume 8, Academic Press.

RUSSELL DL, Kim KH. (1996) Expression of triosephosphate isomerase transcripts in testis: Evidence for retinol regulation and a novel germ cell transcript. Biol Reprod, 55(1):11-18.

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Published Patents

Screening of the TBC1D1 gene for germline mutations; presence of cytidine to thymidine alteration identifies the subject as being at risk for developing obesityUS Patent 7,314,713Publication Date: January 1, 2008Inventors: Shattuck DM, Stone S, RUSSELL DL, Abkevich V, Hunt SAssignee: Myriad Genetics, Inc., University of Utah

Apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depressionUS Patent 7,052,853Publication Date: August 11, 2009Inventors: Shattuck D, RUSSELL DL, Abkevich V, Neff CAssignee: Myriad Genetics, Inc.

Mutant alleles of the angiotensinogen (AGT) gene which cause susceptibility to insulin-dependent diabetes mellitus (IDDM); drug screening, diagnosisUS Patent 6,902,888Publication Date: May 20, 2008Inventors: McGrail M, RUSSELL DL, Shattuck DMAssignee: Myriad Genetics, Inc.

Scientific Meeting Participation

Poster/Abstract PresentationASHG 52nd Annual Meeting, October 2002Title: Germline mutations in angiotensinogen associated with predisposition to type 1 diabetes.Authors: RUSSELL DL, Kronenberg F, Timms KM, McDermott MT, DeGrado J, O'Neill HA, Chen Y, Auinger M, Säly C, Sommer R, Weitgasser R, Hunt SC, Skolnick M, McGrail M, Shattuck DM.

For additional information please see my LinkedIn Profile at https://www.linkedin.com/in/deannarussell