Date Prepared: July 8, 2021

Curriculum Vitae Lance L. Munn, PhD

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Date Prepared: July8,2021

Name: LanceL.Munn

Education 1987 B.S.

summacumlaudeChemicalEngineering Universityof

Cincinnati1993 Ph.D. ChemicalEngineering&Bioengineering

(Advisor:K.Zygourakis)RiceUniversity

Industry Experience 1984-1986 Co-opEngineer Photolithography/Inkformulation Diconix,Inc. (Kodak)Dayton,OH

Postdoctoral Training 06/93-03/96 PostdoctoralFellow BloodRheology&LeukocyteTrafficking

(Advisors:R.Melder,R.K.Jain)MassachusettsGeneralHospital

Faculty Academic Appointments 1996-1998 Instructor RadiationOncology HarvardMedicalSchool1999-2004 AssistantProfessor RadiationOncology HarvardMedicalSchool2004-present AssociateProfessor RadiationOncology HarvardMedicalSchool

Appointments at Hospitals/Affiliated Institutions 1988-1993 Asst.Fellowof

ImmunologyImmunology M.D.AndersonCancerCenter

1993-1996 ResearchFellow RadiationOncology MassachusettsGeneralHospital2004-2016 AssociateBiologist RadiationOncology MassachusettsGeneralHospital2016-present Investigator MGHResearchInstitute MassachusettsGeneralHospital

Major Administrative Leadership Positions

Local

1995-present Director,Bioengineering,Imaging,andComputingCore,SteeleLaboratories

MassachusettsGeneralHospital

2010-present DeputyDirector SteeleLaboratories,MGH2017 Co-chairandorganizer 2017BostonAngiogenesisMeeting

StarrCenter,Boston

Regional

2006-present ProgramSteeringCommitteeMember CityCollegeNewYork/MemorialSloanKetteringCancerCenterPartnershipforCancerResearch,TrainingandCommunityOutreach


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National and International

2012-2014 ExpertPanelist AssessmentofPhysicalSciencesandEngineeringAdvancesinLifeSciencesandOncology(APHELION)inEuropeNCI,OfficeofPhysicalSciencesOncology

2012 Co-ChairandOrganizer USNationalCommitteeonBiomechanics4thSymposiumonFrontiersinBiomechanics:“MechanicsinOncology”

2014 Co-ChairandOrganizer MathematicalBiosciencesInstituteWorkshoponMetastasisandAngiogenesis,OhioStateUniversity

2018 Co-Chair 8thWorldCongressofBiomechanics,Dublin,Ireland

2019-present SABmember SimBioSys,Inc.2020-present ExternalScientificAdvisoryBoard

member CenterforCancerEngineering,TheOhioStateUniversity

2021 Chair,LymphaticModeling LymphaticForum2021

Committee Service

Local

1993-present CandidateSearchCommittee SteeleLaboratories,MGH 1993-96 Chair2016-present Co-Organizer,MGHsite HarvardMedicalSchoolVascularBiology

SeminarSeries

National and International

2013 Thesiscommitteemember Univ.Waterloo,MadjidSoltanidissertation2013 President,thesiscommittee InstitutCurie,KevinAlessandridissertation2016 Externalthesiscommitteemember McGillUniversity,S.Ghaffaridissertation

Professional Societies 1993-present AmericanInstituteofChemicalEngineers 1999–2008 sessionchair2001-present BiomedicalEngineeringSociety 2000-2005 sessionchair2002-present AmericanAssociationforCancerResearch 2002-present RadiationResearchSociety 2010-present MicrocirculatorySociety 2009-present NorthAmericanVascularBiologyAssociation 2017-present AmericanAssociationfortheAdvancement

ofScience


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Grant Review Activities

6/7/00 TransfusionMedicine NIH(NHLBI)AdhocMember

3/23/01 OncologicalSciencesRev.Committee NIH(NCI)AdhocMember

6/2/04-6/10/04 FastLanereviewsystem NationalScienceFoundationAdhocMember

3/9/05 MicroscopicImagingStudySection NIHAdhocMember

10/12–10/13/06 TumorMicroenvironment NIH(NCI)AdhocMember

6/4-6/6/07 Modeling&AnalysisofBiologicalSystems NIHAdhocMember

2010-present SystemsBiology,ZRG1VH-D(55) NIH(NHLBI)Member

1/11-3/12 VascularHematologySEP NIHAdhocMember

3/18/14 SEP/ScientificReviewGroupZEB1OSR-C(M3)Reviewpanel

NIH(NIBIB)AdhocMember

11/19/2015 SEP/ScientificReviewGroup2016/01ZCA1TCRB-T(J2)Reviewpanel

NIH(NCI)AdhocMember

4/14/2016 PhysicalSciencesOncologyCenters(U54)Reviewpanel

NIH(NCI)AdhocMember

2014-present ResearchCouncilKULeuven UniversityofLeuven,BelgiumReviewer

2016-present ResearchGrantsCouncil(RGC)ofHongKong

UniversityGrantsCommitteeReviewer

2/19-2/202019 DrugDiscoveryandMolecularPharmacologyStudySection

NIH(NCI)Ad hoc Member

2019-present ITMOCanceroftheFrenchNationalAllianceforLifeandHealthSciences

Inserm,Reviewer

2/19/2020 HypertensionandMicrovasculature NIH(NHLBI)AdhocMember

Editorial Activities (reviewer)

AmericanJournalofPhysiology LabonaChipAnalyticalChemistry LancetOncologyAnnalsofBiomedicalEngineering MicrocirculationBiorheology MicrovascularResearchBiotechniques NatureCellBiologyCancerCell NatureMethods


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CancerResearch PhysicalReviewLettersIntegrativeBiology PLoSComputationalBiologyJournalofTheoreticalBiology PNAS

Other Editorial Roles 2015-present GuestEditor PNAS2017-present Editor Microcirculation

Honors and Prizes 1987 EngineeringHonorSociety,

TauBetaPiUniversityofCincinnati

1989 CoxFellowship RiceUniversity 1991 PhillipsAwardforPre-

doctoralResearchRiceUniversity

1995 Postdoctoraltraininggrant NIH 2000 LJISTravelAward WhitakerFoundation 2006 Outstandingcoverdesign Taylor&FrancisGroup,

ComputationalandMathematicalMethodsinMedicine

Scientificillustrationforjournalcover

2013 GerritsenAward MicrocirculatorySociety Mostcitedjournalarticle2014 GerritsenAward MicrocirculatorySociety Mostcitedjournalarticle2015 DistinguishedAlumnus

AwardRiceUniversity

2016-present MemberoftheCollegeofFellows

AmericanInstituteforMedicalandBiologicalEngineering

2018 UniversityDelegate,InaugurationofHarvardPresident

RiceUniversity

2020 Top1%compositecitationindex

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000918

Formally Supervised Trainees

1996—1998 Hera Lichtenbeld, PhD/Currently:ProjectManagement,PharmaCell,Maastricht,NetherlandsPostdoctoral,Projecttitle:“VascularPermeabilityofIndividualMicrovessels”Published one paper.

1997—2000 Jin Yuan, PhD/Currently:SeniorResearchScientistatGenoceaBiosciencesPostdoctoral, Project title: “Fluid Dynamics and Leukocyte Adhesion” Published three papers.


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2001-2002 Cristina Sousa/ Doctoral, Project title: “TraffickingofLymphocytesandMetastaticCancerCells”

1998–1999 Gerald Koenig, MD, PhD/Currently:Cardiologist,HenryFordWestBloomfieldHospital,MIPostdoctoral,Projecttitle:“BiophysicsofLymphocyteAdhesioninTumors”Publishedonemanuscript,grantedF32Fellowship,co-authoredpatent.

1998—2000 Yong Chang, PhD/Currently:VicePresidentatIntelliaTherapeutics,Inc.Postdoctoral,Projecttitle:“HydraulicConductivityandPermeabilityofEndothelialMonolayers”Publishedthreepapers,oneinPNAS.

1998—2000 Randall Dull, MD, PhD/Currently:PresidentialEndowedChairinAnesthesiology,Director,LungVascularBiologyLaboratory,AssociateProfessor,Bioengineering,UniversityofUtahPostdoctoral,Projecttitle:“PlGF-VEGFSynergyinEndothelialResponses”Publishedtwopapers.

1998—2001 Emmanuelle di Tomaso, PhD/Currently:VicePresident,TranslationalMedicine,SyrosPharmaceuticals,CambridgeMAPostdoctoral,Projecttitle:“PermeabilityofBrainTumorVasculature”Publishedfourpapers,oneinCancerResearchandoneinPNAS;receivedClaflinDistinguishedScholarAward,andMartinPrize

2000—2001 Cristiano Migliorini, PhD/Currently:ExecutiveDirectoratBankVontobelAG,Geneva,SwitzerlandPostdoctoral,Projecttitle:“ModelingFluidDynamicsandLeukocyteAdhesion”Publishedthreepapers.

2000-2002 RobertCampbell,PhD/Currently:AssociateProfessor,MassachusettsCollegeofPharmacyandHealthSciencesPostdoctoral,Projecttitle:“DeliveryofLiposomestoTumorVessels”Publishedonepaper,CancerResearch.

2000-2003 Maximilian Bockhorn, MD, PhD/Currently:Surgeon,DepartmentofGeneral&TransplantSurgery;UniversityHospital,Essen,GermanyPostdoctoral,Projecttitle:“AnalysisofCancerCellsShedfromaSolidTumor”Publishedtwopapers,LancetOncologyandCancerResearch.

2000-2003 Neil Forbes, PhD/Currently:Professor,U.MassachusettsAmherstPostdoctoral,Projecttitle:“TreatingTumorswithPenetratingBacteria”Publishedonepaper,CancerResearch.

2002-2006 Chenghai Sun, PhD/Currently:Sr.ResearchScientist,ExaCorp.,Burlington,MAPostdoctoral,Projecttitle:“Lattice-BoltzmannModelingofHemodynamics”Publishedfivepapers,twoinBiophysicalJournal.

2003-2007 Aaron Mulivor, PhD/Currently:SeniorAssociate,Pharma&LifeSciencesAdvisoryatPwCPostdoctoral,Projecttitle:“BloodDynamicsandAtherosclerosis”

2004-2008 Michael Dupin, PhD/Currently:DirectorofPPNRAnalytics,SVPatCitizensBank,Boston,MAPostdoctoral,Projecttitle:“3DSimulationofBloodRheology”Publishedthreepapers.

2004-2010 Janet Tse/ Currently:PatentAgent,NixonPeabodyLLP,BostonDoctoral,Projecttitle:“TumorSolidStress”Published1paper,PNAS.


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2005-2009 Gang Cheng, PhD/Currently:HeadofScientificLiaisonatRocheChinaPostdoctoral,Projecttitle:“CellularmechanismsofAngiogenesis”Published2papers,oneinBlood.

2006-2009 James Alex Tyrrell, PhD/Currently:VicePresident,PlatformSearchCapabilityatThomsonReutersPostdoctoral,Projecttitle:“QuantitativeImageAnalysisofVascularNetworks”Publishedthreepapers.Co-authoredsuccessfulR01application(R01CA149285).

2006-2011 Delphine Lacorre, PhD / Currently: Research Engineer, Lille, France Postdoctoral,Projecttitle:“EffectsofVascularNormalizationonDrugDelivery”Publishedtwopapers;receivedKomenFellowship.

2006-2011 Walid Kamoun, PhD/Currently:AssociateDirector-ResearchTeamLeader,MerrimackPharmaceuticalsPostdoctoral,Projecttitle:“BloodFlowDistributioninTumors”Publishedfivepapers,oneinNatureMethods;receivedKomenFellowship.

2008-2011 Temitope Sodunke, PhD/ Currently:Strategy,Innovation,MedicalDeviceProfessionalatBDPostdoctoral,Projecttitle:“StromalDeterminantsofCancerCellInvasion”ReceivedMerckPostdoctoralFellowship.

2008-2011 Abhishek Jain, PhD/Currently:AssistantProfessor,TexasA&M;Doctoral,Projecttitle:“BloodMicrofluidics”Publishedthreepapers,oneinLabChip

2008-2014 Jonathan Song, PhD /Currently:AssociateProfessor,OhioStateUniversityPostdoctoral,Projecttitle:“Fluidforcescontrolendothelialmorphogenesis”Publishedthreepapers,PNAS,LabChip,IntegrativeBiology

2010-2015 Christian Kunert, PhD/ Currently:Amgen,Cambridge,MAPostdoctoral,Projecttitle:“Mechanobiologyoflymphatictransport”ReceivedDFGFellowship;publicationinPNAS

2011-2015 Gabriel Gruionu, PhD/ Currently:Instructor,MassachusettsGeneralHospitalPostdoctoral,Projecttitle:“Determinantsofvascularremodelingintumors”Published2patentsandonepaper

2011-2016 Despina Bazou, PhDPostdoctoral,Projecttitle:“Endothelialdynamicsandtumortissueengineering”Published5papers

2012-2019 Nir Maimon, PhDPostdoctoral,Projecttitle:“Communicationbetweenbloodvesselcellsintumors”

2014-2019 Hadi Tavakoli Nia, PhD Postdoctoral,Projecttitle:Quantifyingtumormechanopathologies

2017-present Huabing Li, PhDPostdoctoral,Projecttitle:“Lymphaticvalvemechanics”

2018-present Mohammad Reza NikmaneshiDoctoral,Projecttitle:“Tumorengineeringandangiogenesis”

2020-present Mohammad Razavi Postdoctoral,Projecttitle:“Systemsbiologyofanti-cancerimmunity”


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2020-present Tuoye Xu Postdoctoral,Projecttitle:“Stress-inducedtumorimmunesuppression”

2021-present Meghan O’Melia Postdoctoral,Projecttitle:“Lymphocytetraffickingandcancerimmunology”

Local Invited Presentations No presentations below were sponsored by outside entities

November3,2008 “Multiscaleanalysesofblooddynamics.”MartinosCenterforBiomedicalImaging,NeurovascularSeminarSeries,MGH,Charlestown,MA

October14,2009 “Blooddynamicsandtumormicro-anatomy.”HarvardCatalyst,CenterforNanoscaleSystemsSpecialSeminar:ApplyingNanoscaleTechnologiesinBiomedicalResearch,CambridgeMA.

November5,2010 “Connectionofvascularnetworksviawrapping-and-tappinganastomosis.”BostonAngiogenesisMeeting,MEEI,2010,BostonMA

March8,2011 "Microanatomyandmechanobiology:howthecellmicroenvironmentinfluencescoordinatedmigrationandvascularmorphogenesis."TopicsinBioengineeringSeminarSeries,HarvardSchoolofEngineeringandAppliedSciences(SEAS),Cambridge,MA.

April21,2013 “MechanobiologyofVascularDynamics.”MechanicalForcesinDevelopmentmeeting,TuftsMedicalSchool,Boston

November7,2013 “Biomechanicalcontrolofvesselmorphogenesis,adaptationandfunction.”BostonAngiogenesisMeeting,MEEI,2013,BostonMA

March8,2013 “VascularBiologyandMechanobiology.”MGHT32LectureSeriesNovember4,2015 “Untanglingtumorvasculature.”BostonAngiogenesisMeeting,MEEI,2015,BostonMANovember9,2020 “PhysicalTraitsofCancer.”LudwigCenter,HarvardMedicalSchoolJanuary26,2021 “SystemsBiologyModelingofCOVID-19.” NanomedicineAcademyatNortheastern

UniversityLectureSeries

Report of Regional, National and International Invited Teaching and Presentations Thosepresentationsbelowsponsoredbyoutsideentitiesaresonotedandthesponsorisidentified.

Invited Presentations and Courses

Regional

March31,2009 “Multi-scaleAnalysesoftumorphysiologyandbloodvesseldynamics.”2009SeminarSeries,CenterforFluidDynamics,BrownUniversity,Providence,RI.

National

July23-28,1995 “TheRoleofErythrocytesinLeukocyte-EndothelialInteractions.”AnnualConferenceonBiorheologyandClinicalHemorheology,BigSky,MT.

October4-6,1996 “QuantificationofMetastaticCellArrest,Extravasation,andColonization.”AnnualMeetingoftheBiomedicalEngineeringSociety,PennStateUniversity.

June4,1999 "MolecularDeterminantsofTumorPathophysiology."AmericanAssociationofClinicalChemistryMeeting,Boston,MA


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June25-26,1999 “TransvascularTransportinTumors.”8thAnnualWorkshoponAdvancedMethodsofPharmacokineticandPharmacodynamicSystemsAnalysis,LosAngeles,CA.

Jan11-15,2000 "VisualizationandQuantificationofGeneFunctioninVivo.”QuantitativeChallengesinthePost-genomicSequenceEra:AWorkshopandSymposium,SanDiego,CA

January19,2001 “TumorAngiogenesisattheCellularLevel.”(MayoClinic)MayoClinicGoldmanSymposiumonInnovativeResearchinMultipleMyeloma,AmeliaIsland,FL

April29,2001 “VascularDevelopmentandAnti-angiogenicStrategies.”PediatricAcademicSocieties’2001AnnualMeeting,Baltimore,MD

November8,2001 “Modelingleukocyteadhesioninsmallvessels:aLatticeBoltzmannapproach.”PlenaryTalk(selectedabstract),AmericanInstituteofChemicalEngineeringAnnualMeeting,Reno,NV

September6-8,2002

“TumorPhysicsandBiology:ImpactofAberrantVascularArchitectureonTherapy.”ThirdAnnualBioMEMs&BiomedicalNanotechnologyWorld2002Columbus,OH

October25,2002 “InfluenceofVesselGeometryonLeukocyteAdhesion:aLattice-BoltzmannModel.”AnnualMeetingoftheBiomedicalEngineeringSociety,Houston,TX.

February27,2003 “TumorVesselAbnormalitiesandLeukocyte-ErythrocyteDynamics.”PennStateUniversity,StateCollege,PA

November11,2004 “Microfluidicdeviceforauto-separationofwhitebloodcellsfromwholeblood.”PlenaryTalk(selectedabstract),AmericanInstituteofChemicalEngineeringAnnualMeeting,Austin,TX

December1,2004 “Reverseengineeringofbloodcelldynamics.”CityCollegeofNewYork,Fall2004SeminarSeries,DepartmentofBiomedicalEngineering

February17-21,2005

“TheTumorMicroenvironment:ModelingandExperimentalValidation.“MathematicalOncology:BridgingtheScientificDivide,AAASAnnualMeeting,WashingtonDC

May10,2005 “BiomimeticDesignofaMicrofluidicDeviceforAuto-separationofLeukocytesfromWholeBlood.”NSTINanotechnologyConference,AnaheimCA

December18-19,2006

“Microfluidicsandparticletransportintumors.”FineParticleSocietyNanotechnologyinLifeSciencesSymposium,SanDiego,CA

December18-21,2006

“BiomimeticDesignofaMicrofluidicDeviceforAuto-separationofLeukocytesfromWholeBlood.”SymposiumonNanotechnologyinLifeSciences20thInternationalConferenceonBioandPharmaceuticalScienceandTechnology,SanDiego,CA

October2-4,2008 “IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,StLouis,MA

October26-28,2008

“IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”NCIInnovativeMolecularAnalysisTechnologies(IMAT)program,Cambridge,MA

November30,2008 “IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”MaterialsResearchSociety:CancerNanotechnologyMedSchool–RealWorldChallengesandNano’sStrengthsinCancerPrevention,Diagnosis,andTreatment,Boston,MA

January26-30,2009

“Multi-scaletumorphysiologyandbloodvesseldynamics.”MathematicalBiosciencesInstituteWorkshoponCancerDevelopment,Angiogenesis,ProgressionandInvasion,Columbus,OH

October8,2009 “Tumorbloodvesseldynamics.”QuantitativePharmacologyTechnicalSummit(EliLilly),Indianapolis,IN

October7-10,2009 “Tumorbloodvesseldynamics.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,Pittsburgh,PA

November23,2009 “Tumorbloodvesseldynamics.”62ndAnnualMeetingoftheAPSDivisionofFluidDynamics,Minneapolis,Minnesota


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April24-28,2010 “Wrapping-and-tappinganastomosisbetweenengraftedendothelialnetworksandhostvasculature.”PlenaryTalk(selectedabstract),ExperimentalBiologyMeeting,Anaheim,CA

October6-8,2010 “Wrapping-and-tappinganastomosisbetweenengraftedendothelialnetworksandhostvasculature.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,Austin,MA

November1-2,2010 “Compression-inducedcancercellinvasion:don’tpushme‘causeI’mclosetotheedge.”UCSD/NSFPhysicsofCancerMetastasisMeetingArlington,VA

April3-6,2011 “Tumorvesseldynamicsduringanti-angiogenictherapy.”AmericanConferenceonPharmacometrics,SanDiego,CA

Aug30-Sept3,2011 “Cell-MatrixInteractionswithinTumorsandNormalTissue.”33rdAnnualInternationalConferenceoftheIEEEEngineeringinMedicineandBiologySocietyBoston,MA

March7,2011 “Tumorbloodvesseldynamics.”PhysicalSciences–OncologyCenterSteeringCommitteemeeting

October28,2011 "Imagingvasculardynamics"MultiscaleSystemsBiologyworkinggroupoftheMultiscaleModeling(MSM)Consortium

October24,2012 “SolidandFluidBiomechanicsintheTumorEnvironment”.USNationalCommitteeonBiomechanics4thSymposiumonFrontiersinBiomechanics:MechanicsinOncology

April2,2013 “MechanobiologyandVascularDynamics,”IMESeminarSeries,UniversityofPennsylvania

September27,2013 "Biomechanicaldeterminantsofcellinvasion,angiogenesisandlymphaticfunction."CusterWorkplaceLectureSeries,UniversityofWesternMichigan

October15,2014 “Biomechanicsofcancerinvasionandvesselfunction.”MathematicalBiosciencesInstituteWorkshoponMetastasisandAngiogenesis,Columbus,OH.

April3,2015 “Deconvolvingtumordynamics.”DepartmentofMechanicalandAerospaceEngineeringSeminarSeries,OhioStateUniversity

March29,2016 “Deconvolvingtumordynamics.”RiceUniversity'sBioengineeringColloquiumOctober27,2016 “SystemsBiologyofLymphTransport.” NHLBISystemsBiologymeeting,Bethesda,MD. April10,2018 “TumorEngineeringandMechanobiology.”DepartmentofChemicalandBiomolecular

EngineeringSeminarSeries,OhioStateUniversitySeptember7,2018 “Engineeredtumorsforpersonalizedmedicine.”DukeUniversityLectureSeries,Durham,

NCMarch5,2019 “Reverseengineeringtumorsandvasculature.”(Keynote)UniversityofNorthCarolina

IntegrativeVascularBiologyresearchsymposium.ChapelHill,NCSeptember12,2019 “Mechanobiologicalcontrolofvascularfunction.”AmericanPhysiologicalSociety

meeting,Interfaceofmathematicalmodelsandexperimentalbiology:Roleofmicrovasculature.Scottsdale,AZ

January20,2020 “ReengineeringthePhysicalMicroenvironmentofTumorstoImproveTreatmentResponse”CambridgeHealthtechInstitute;EngineeringNextGenerationCancerImmunotherapies;Partofthe19thAnnualPepTalk,SanDiego,CA

July20,2020 “OptimizingtreatmentforCOVID-19usingcomputationalmodelling:Implicationsforcancerpatients.”AACRVirtualMeeting:COVID-19andCancer.

International


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August25-30,1996 “InteractionofActivatedLeukocyteswithTumorVessels.”SixthWorldCongressforMicrocirculation,Munich,Germany

October3-7,1998 “TumorAngiogenesisandMicrocirculation.”10thAnnualConferenceoftheInternationalSocietyofDifferentiation,Houston,TX

Oct22-25,1999 “TumorAngiogenesis.”ConferenceonAngiogenesisandTumors,Paris,FranceOct12-15,2002 “TumorVesselAbnormalities.”SecondInterdisciplinaryEuroconferenceonAngiogenesis,

Cascals,PortugalApril23-24,2004 “Theinteractionofcirculatingcellswithtumors:pharmacokineticandfluiddynamic

models.”WorkshoponMathematicalOncology,TheFieldsInstitute,Toronto,ON August1,2006 “Tumorvesselabnormalitiesaffectbloodcelldynamicsandflowdistribution.” Cancerand

Bioengineering;WorldCongressofBiomechanics,MunichGermanyJuly2-4,2008 “Multi-scaleanalysesoftumorphysiologyandbloodvesseldynamics.”FieldsInstitute

WorkshoponGrowthandControlofTumors:TheoryandExperimentToronto,CAJuly9-13,2008 “Blooddynamicsinnormalandabnormalvesselnetworks.”InternationalCongressof

Biorheology,PennStateUniversity,StateCollege,PAJanuary4-7,2010 “ModelingTumorbloodvesseldynamics.”WorkshoponMathematicalMethodsin

SystemsBiology,TelAviv,IsraelMarch18-20,2010 “ModelingTumorbloodvesseldynamics.”FieldsInstituteWorkshoponMathematical

OncologyToronto,CAMay10-12,2010 “ModelingTumorbloodvesseldynamics.”CentreEuropeandeCalculAtomiqueet

Moleculaire(CECAM)WorkshoponTrendsinComputationalHemodynamics,Lausanne,Switzerland

Sept.17-20,2011 “Vasculardynamicsandanti-angiogenictherapy.”Tumor-VesselInterfacemeeting,KlosterSeeonGermany

March28-30,2011 “Targetingvasculardynamics.”VIIthAcademicianNicolaeCajalSymposium,Bucharest,Romania

December3,2013 “Biomechanicaldeterminantsofmorphogenesisandvascularfunction”InstitutCurie,ParisFrance

May29-30,2014 “Microsystemsforprobingblood,vesselandtumordynamics.”(Keynote)Ontario-on-a-ChipConference,UniversityofToronto,Toronto,CA

July6-11,2014 “BiomechanicalControlofVesselMorphogenesis,AdaptationandFunction.”SeventhWorldCongressofBiomechanics,Boston,MA

July6-11,2014 “Biomechanicalautoregulationoflymphatictransport.”SeventhWorldCongressofBiomechanics,Boston,MA

October2-8,2014 "Biomechanicalprocessesandtopologicaldynamicsintumors"AnnualSymposiumofPhysicsofCancer,UniversityofLeipzig

June25-28,2016 "Visualizingcellandmatrixdynamicsintumors"AACRSpecialConferenceonEngineeringandPhysicalSciencesinOncology,WestinBostonWaterfront,Boston,MA

February5-9,2017 “Tumorsolidstressandmechanobiology”PhysicalScienceofCancerGordonResearchConference,Galveston,TX

Dec.7-10,2017 “Acceleratingrevascularization.”InnovationsinWoundHealingConference,Bimini,Bahamas.

July10,2018 “Leaky Blood Vessels, GAGs and Metastasis” World Congress of Biomechanics 2018, Dublin, Ireland

June1,2020 Keynote talk, “Physical Hallmarks of Cancer,” Third Workshop on Hallmarks in cancer and the development of diagnostic tools, Porto, Portugal. [Cancelled due to COVID-19 pandemic]


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Report of Scholarship Publications

Peer reviewed publications in print or other media [more than 15,000 citations; h-index= 63 (Web of Science); 67 (Google Scholar)]

Research Investigations 1. MunnLL,GlackenMW,McintyreBW,ZygourakisK.Analysisoflymphocyteaggregationusingdigital

imageanalysis.JImmunolMethods.1993;166:11-25.2. TeagueTK,MunnL,ZygourakisK,McintyreBW.Analysisoflymphocyteactivationandproliferationby

videomicroscopyanddigitalimaging.Cytometry.1993;14:772-82.3. MunnLL,MelderRJ,JainRK.Analysisofcellfluxintheparallelplateflowchamber:implicationsforcell

capturestudies.BiophysJ.1994;67:889-95.4. MelderRJ,MunnLL,YamadaS,OhkuboC,JainRK.Selectin-andintegrin-mediatedT-lymphocyterolling

andarrestonTNF-alpha-activatedendothelium:augmentationbyerythrocytes.BiophysJ.1995;69:2131-8.

5. MunnLL,KoenigGC,JainRK,MelderRJ.Kineticsofadhesionmoleculeexpressionandspatialorganizationusingtargetedsamplingfluorometry.Biotechniques.1995;19:622-6,628-31.

6. MelderRJ,KoenigGC,MunnLL,JainRK.Adhesionofactivatednaturalkillercellstotumornecrosisfactor-alpha-treatedendotheliumunderphysiologicalflowconditions.NatImmun.1996a;15:154-63.

7. MelderRJ,KoenigGC,WitwerBP,SafabakhshN,MunnLL,JainRK.Duringangiogenesis,vascularendothelialgrowthfactorandbasicfibroblastgrowthfactorregulatenaturalkillercelladhesiontotumorendothelium.NatMed.1996b;2:992-7.

8. MunnLL,MelderRJ,JainRK.Roleoferythrocytesinleukocyte-endothelialinteractions:mathematicalmodelandexperimentalvalidation.BiophysJ.1996;71:466-78.

9. PatanS,MunnLL,JainRK.Intussusceptivemicrovasculargrowthinahumancolonadenocarcinomaxenograft:anovelmechanismoftumorangiogenesis.MicrovascRes.1996;51:260-72.

10. NeelameghamS,MunnLL,ZygourakisK.Amodelforthekineticsofhomotypiccellularaggregationunderstaticconditions.BiophysJ.1997;72:51-64.

11. ShiodaT,MunnLL,FennerMH,JainRK,IsselbacherKJ.Earlyeventsofmetastasisinthemicrocirculationinvolvechangesingeneexpressionofcancercells.TrackingmRNAlevelsofmetastasizingcancercellsinthechickembryochorioallantoicmembrane.AmJPathol.1997;150:2099-112.

12. LichtenbeldHC,FerarraN,JainRK,MunnLL.Effectoflocalanti-VEGFantibodytreatmentontumormicrovesselpermeability.MicrovascRes1999;57:357-62.

13. ChangYS,diTomasoE,McDonaldDM,JonesR,JainRK,MunnLL.Mosaicbloodvesselsintumors:frequencyofcancercellsincontactwithflowingblood.ProcNatlAcadSciUSA.2000a;97:14608-13.

14. ChangYS,MunnLL,HillsleyMV,DullRO,YuanJ,LakshminarayananS,GardnerTW,JainRK,TarbellJM.Effectofvascularendothelialgrowthfactoronculturedendothelialcellmonolayertransportproperties.MicrovascRes.2000b;59:265-77.

15. MelderRJ,YuanJ,MunnLL,JainRK.Erythrocytesenhancelymphocyterollingandarrestinvivo.MicrovascRes.2000;59:316-22.

16. DaviesCdeL,MelderRJ,MunnLL,Mouta-CarreiraC,JainRK,BoucherY.Decorininhibitsendothelialmigrationandtube-likestructureformation:roleofthrombospondin-1.MicrovascRes.2001;62:26-42.

17. DullRO,YuanJ,ChangYS,TarbellJ,JainRK,MunnLL.Kineticsofplacentagrowthfactor/vascularendothelialgrowthfactorsynergyinendothelialhydraulicconductivityandproliferation.MicrovascRes.2001;61:203-10.

18. MelderRJ,KristensenCA,MunnLL,JainRK.ModulationofA-NKcellrigidity:Invitrocharacterizationandinvivoimplicationsforcelldelivery.Biorheology.2001;38:151-9.

19. PatanS,MunnLL,TandaS,RobergeS,JainRK,JonesRC.Vascularmorphogenesisandremodelinginamodeloftissuerepair:bloodvesselformationandgrowthintheovarianpedicleafterovariectomy.CircRes.2001a;89:723-31.


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20. PatanS,TandaS,RobergeS,JonesRC,JainRK,MunnLL.Vascularmorphogenesisandremodelinginahumantumorxenograft:bloodvesselformationandgrowthafterovariectomyandtumorimplantation.CircRes.2001b;89:732-9.

21. YuanJ,MelderRJ,JainRK,MunnLL.Lateralviewflowsystemforstudiesofcelladhesionanddeformationunderflowconditions.Biotechniques.2001;30:388-94.

22. CampbellRB,FukumuraD,BrownEB,MazzolaLM,IzumiY,JainRK,TorchilinVP,MunnLL.Cationicchargedeterminesthedistributionofliposomesbetweenthevascularandextravascularcompartmentsoftumors.CancerRes.2002;62:6831-6.

23. FriedrichSW,LinSC,StollBR,BaxterLT,MunnLL,JainRK.Antibody-directedeffectorcelltherapyoftumors:analysisandoptimizationusingaphysiologicallybasedpharmacokineticmodel.Neoplasia.2002;4:449-63.

24. KoikeC,MckeeTD,PluenA,RamanujanS,BurtonK,MunnLL,BoucherY,JainRK.Solidstressfacilitatesspheroidformation:potentialinvolvementofhyaluronan.BrJCancer.2002;86:947-53.

25. MelderRJ,MunnLL,StollBR,MarecosEM,BaxterLT,WeisslederR,JainRK.Systemicdistributionandtumorlocalizationofadoptivelytransferredlymphocytesinmice:comparisonwithphysiologicallybasedpharmacokineticmodel.Neoplasia.2002;4:3-8.

26. MiglioriniC,QianY,ChenH,BrownEB,JainRK,MunnLL.Redbloodcellsaugmentleukocyterollinginavirtualbloodvessel.BiophysJ.2002;83:1834-41.

27. PaderaTP,KadambiA,diTomasoE,CarreiraCM,BrownEB,BoucherY,ChoiNC,MathisenD,WainJ,MarkEJ,MunnLL,JainRK.Lymphaticmetastasisintheabsenceoffunctionalintratumorlymphatics.Science.2002;296:1883-6.

28. ForbesNS,MunnLL,FukumuraD,JainRK.SparseinitialentrapmentofsystemicallyinjectedSalmonellatyphimuriumleadstoheterogeneousaccumulationwithintumors.CancerRes.2003;63:5188-93.

29. FriedrichEB,TagerAM,LiuE,PetterssonA,OwmanC,MunnL,LusterAD,GersztenRE.MechanismsofleukotrieneB4--triggeredmonocyteadhesion.ArteriosclerThrombVascBiol.2003;23:1761-7.

30. RooseT,NettiPA,MunnLL,BoucherY,JainRK.Solidstressgeneratedbyspheroidgrowthestimatedusingalinearporoelasticitymodel.MicrovascRes.2003;66:204-12.

31. StollBR,MiglioriniC,KadambiA,MunnLL,JainRK.Amathematicalmodelofthecontributionofendothelialprogenitorcellstoangiogenesisintumors:implicationsforantiangiogenictherapy.Blood.2003;102:2555-61.

32. SunC,MiglioriniC,MunnLL.Redbloodcellsinitiateleukocyterollinginpostcapillaryexpansions:alatticeBoltzmannanalysisBiophysJ.2003;85:208-22.

33. BockhornM,RobergeS,SousaC,JainRK,MunnLL.Differentialgeneexpressioninmetastasizingcellsshedfromkidneytumors.CancerRes.2004;64:2469-73.

34. DudaDG,FukumuraD,MunnLL,BoothMF,BrownEB,HuangP,SeedB,JainRK.Differentialtransplantabilityoftumor-associatedstromalcells.CancerRes.2004;64:5920-4.

35. WillettCG,BoucherY,diTomasoE,DudaDG,MunnLL,TongRT,ChungDC,SahaniDV,KalvaSP,KozinSV,MinoM,CohenKS,ScaddenDT,HartfordAC,FischmanAJ,ClarkJW,RyanDP,ZhuAX,BlaszkowskyLS,ChenHX,ShellitoPC,LauwersGY,JainRK.DirectevidencethattheVEGF-specificantibodybevacizumabhasantivasculareffectsinhumanrectalcancer.NatMed.2004;10:145-7.

36. WinklerF,KozinSV,TongRT,ChaeSS,BoothMF,GarkavtsevI,XuL,HicklinDJ,FukumuraD,diTomasoE,MunnLL,JainRK.KineticsofvascularnormalizationbyVEGFR2blockadegovernsbraintumorresponsetoradiation:roleofoxygenation,angiopoietin-1,andmatrixmetalloproteinases.CancerCell.2004;6:553-63.

37. DemouZN,AwadM,MckeeT,PerentesJY,WangX,MunnLL,JainRK,BoucherY.LackoftelopeptidesinfibrillarcollagenIpromotestheinvasionofametastaticbreasttumorcellline.CancerRes.2005;65:5674-82.

38. diTomasoE,CapenD,HaskellA,HartJ,LogieJJ,JainRK,McDonaldDM,JonesR,MunnLL.Mosaictumorvessels:cellularbasisandultrastructureoffocalregionslackingendothelialcellmarkers.CancerRes.2005;65:5740-9.

39. KashiwagiS,IzumiY,GohongiT,DemouZN,XuL,HuangPL,BuerkDG,MunnLL,JainRK,FukumuraD.NOmediatesmuralcellrecruitmentandvesselmorphogenesisinmurinemelanomasandtissue-engineeredbloodvessels.JClinInvest.2005;115:1816-27.


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40. ShevkoplyasSS,YoshidaT,MunnLL,BitenskyMW.Biomimeticautoseparationofleukocytesfromwholebloodinamicrofluidicdevice.AnalChem.2005;77:933-7.

41. SunC,MunnLL.Particulatenatureofblooddeterminesmacroscopicrheology:a2-DlatticeBoltzmannanalysis.BiophysJ.2005;88:1635-45.

42. WillettCG,BoucherY,DudaDG,diTomasoE,MunnLL,TongRT,KozinSV,PetitL,JainRK,ChungDC,SahaniDV,KalvaSP,CohenKS,ScaddenDT,FischmanAJ,ClarkJW,RyanDP,ZhuAX,BlaszkowskyLS,ShellitoPC,Mino-KenudsonM,LauwersGY.Surrogatemarkersforantiangiogenictherapyanddose-limitingtoxicitiesforbevacizumabwithradiationandchemotherapy:continuedexperienceofaphaseItrialinrectalcancerpatients.JClinOncol.2005;23:8136-9.

43. JonesR,CapenD,JacobsonM,MunnL.PDGFandmicrovesselwallremodelinginadultratlung:imagingPDGF-AAandPDGF-Ralphamoleculesinprogenitorsmoothmusclecellsdevelopinginexperimentalpulmonaryhypertension.CellTissueRes.2006;326:759-69.

44. DupinMM,HallidayI,CareCM,AlboulL,MunnLL.Modelingtheflowofdensesuspensionsofdeformableparticlesinthreedimensions.PhysRevEStatNonlinSoftMatterPhys.2007;75:066707.

45. JainRK,TongRT,MunnLL.Effectofvascularnormalizationbyantiangiogenictherapyoninterstitialhypertension,peritumoredema,andlymphaticmetastasis:insightsfromamathematicalmodel.CancerRes.2007;67:2729-35.

46. SunC,JainRK,MunnLL.Non-uniformplasmaleakageaffectslocalhematocritandbloodflow:implicationsforinflammationandtumorperfusion.AnnBiomedEng.2007;35:2121-9.

47. JonesRC,CapenDE,CohenKS,MunnLL,JainRK,DudaDG.Aprotocolforphenotypicdetectionandcharacterizationofvascularcellsofdifferentoriginsinalungneovascularizationmodelinrodents.NatProtoc.2008;3:388-97.

48. DupinMM,HallidayI,CareCM,MunnLLEfficiency-oriented,hybridapproachformodelingdeformableparticlesinthreedimensions.ProgressinComputationalFluidDynamics.2008;8109-120

49. MunnLL,DupinMM.Bloodcellinteractionsandsegregationinflow.AnnBiomedEng.2008;36:534-44.50. SunC,MunnLL.LatticeBoltzmannsimulationofbloodflowindigitizedvesselnetworks.ComputMath

Appl.2008;55:1594-1600.51. AuP,TamJ,DudaDG,LinPC,MunnLL,FukumuraD,JainRK.ParadoxicaleffectsofPDGF-BB

overexpressioninendothelialcellsonengineeredbloodvesselsinvivo.AmJPathol.2009;175:294-302.52. ChengG,TseJ,JainRK,MunnLL.Micro-environmentalmechanicalstresscontrolstumorspheroidsize

andmorphologybysuppressingproliferationandinducingapoptosisincancercells.PLoSOne.2009;4:e4632.

53. diTomasoE,LondonN,FujaD,LogieJ,TyrrellJA,KamounW,MunnLL,JainRK.PDGF-Cinducesmaturationofbloodvesselsinamodelofglioblastomaandattenuatestheresponsetoanti-VEGFtreatment.PLoSOne.2009;4:e5123.

54. JainA,MunnLL.Determinantsofleukocytemarginationinrectangularmicrochannels.PLoSOne.2009;4:e7104.

55. KamounWS,LeyCD,FarrarCT,DuyvermanAM,LahdenrantaJ,LacorreDA,BatchelorTT,diTomasoE,DudaDG,MunnLL,FukumuraD,SorensenAG,JainRK.Edemacontrolbycediranib,avascularendothelialgrowthfactorreceptor-targetedkinaseinhibitor,prolongssurvivaldespitepersistentbraintumorgrowthinmice.JClinOncol.2009;27:2542-52.

56. PerentesJY,MckeeTD,LeyCD,MathiewH,DawsonM,PaderaTP,MunnLL,JainRK,BoucherY.Invivoimagingofextracellularmatrixremodelingbytumor-associatedfibroblasts.NatMethods.2009;6:143-5.

57. VakocBJ,LanningRM,TyrrellJA,PaderaTP,BartlettLA,StylianopoulosT,MunnLL,TearneyGJ,FukumuraD,JainRK,BoumaBE.Three-dimensionalmicroscopyofthetumormicroenvironmentinvivousingopticalfrequencydomainimaging.NatMed.2009;15:1219-23.

58. ChaeSS,KamounWS,FarrarCT,KirkpatrickND,NiemeyerE,DeGraafAM,SorensenAG,MunnLL,JainRK,FukumuraD.Angiopoietin-2interfereswithanti-VEGFR2-inducedvesselnormalizationandsurvivalbenefitinmicebearinggliomas.ClinCancerRes.2010;16:3618-27.

59. KamounWS,ChaeSS,LacorreDA,TyrrellJA,MitreM,GillissenMA,FukumuraD,JainRK,MunnLL.SimultaneousmeasurementofRBCvelocity,flux,hematocritandshearrateinvascularnetworks.NatMethods.2010;7:655-60.


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60. StylianopoulosT,Diop-FrimpongB,MunnLL,JainRK.Diffusionanisotropyincollagengelsandtumors:theeffectoffibernetworkorientation.BiophysJ.2010a;99:3119-28.

61. StylianopoulosT,PohMZ,InsinN,BawendiMG,FukumuraD,MunnLL,JainRK.Diffusionofparticlesintheextracellularmatrix:theeffectofrepulsiveelectrostaticinteractions.BiophysJ.2010b;99:1342-9.

62. BaishJW,StylianopoulosT,LanningRM,KamounWS,FukumuraD,MunnLL,JainRK.Scalingrulesfordiffusivedrugdeliveryintumorandnormaltissues.ProcNatlAcadSciUSA.2011;108:1799-803.

63. ChengG,LiaoS,KitWongH,LacorreDA,diTomasoE,AuP,FukumuraD,JainRK,MunnLL.Engineeredbloodvesselnetworksconnecttohostvasculatureviawrapping-and-tappinganastomosis.Blood.2011;118:4740-9.

64. JainA,MunnLL.Biomimeticpostcapillaryexpansionsforenhancingrarebloodcellseparationonamicrofluidicchip.LabChip.2011;11:2941-7.

65. LiaoS,ChengG,ConnerDA,HuangY,KucherlapatiRS,MunnLL,RuddleNH,JainRK,FukumuraD,PaderaTP.Impairedlymphaticcontractionassociatedwithimmunosuppression.ProcNatlAcadSciUSA.2011;108:18784-9.

66. PerentesJY,KirkpatrickND,NaganoS,SmithEY,ShaverCM,SgroiD,GarkavtsevI,MunnLL,JainRK,BoucherY.Cancercell-associatedMT1-MMPpromotesbloodvesselinvasionanddistantmetastasisintriple-negativemammarytumors.CancerRes.2011;71:4527-38.

67. SongJW,MunnLL.Fluidforcescontrolendothelialsprouting.ProcNatlAcadSciUSA.2011;108:15342-7.

68. HuangY,YuanJ,RighiE,KamounWS,AncukiewiczM,NezivarJ,SantosuossoM,MartinJD,MartinMR,VianelloF,LeblancP,MunnLL,HuangP,DudaDG,FukumuraD,JainRK,PoznanskyMC.Vascularnormalizingdosesofantiangiogenictreatmentreprogramtheimmunosuppressivetumormicroenvironmentandenhanceimmunotherapy.ProcNatlAcadSciUSA.2012;109:17561-6.

69. PlotkinSR,BredellaMA,CaiW,KassarjianA,HarrisGJ,EsparzaS,MerkerVL,MunnLL,MuzikanskyA,AskenaziM,NguyenR,WenzelR,MautnerVF.Quantitativeassessmentofwhole-bodytumorburdeninadultpatientswithneurofibromatosis.PLoSOne.2012;7:e35711.

70. SongJW,BazouD,MunnLL.Anastomosisofendothelialsproutsformsnewvesselsinatissueanalogueofangiogenesis.IntegrBiol(Camb).2012a;4:857-62.

71. SongJW,DaubriacJ,TseJM,BazouD,MunnLL.RhoAmediatesflow-inducedendothelialsproutingina3-Dtissueanalogueofangiogenesis.LabChip.2012b;12:5000-6.

72. StylianopoulosT,MartinJD,ChauhanVP,JainSR,Diop-FrimpongB,BardeesyN,SmithBL,FerroneCR,HornicekFJ,BoucherY,MunnLL,JainRK.Causes,consequences,andremediesforgrowth-inducedsolidstressinmurineandhumantumors.ProcNatlAcadSciUSA.2012;109:15101-8.

73. TseJM,ChengG,TyrrellJA,Wilcox-AdelmanSA,BoucherY,JainRK,MunnLL.Mechanicalcompressiondrivescancercellstowardinvasivephenotype.ProcNatlAcadSciUSA.2012;109:911-6.

74. KirkpatrickND,ChungE,CookDC,HanX,GruionuG,LiaoS,MunnLL,PaderaTP,FukumuraD,JainRK,Video-rateresonantscanningmultiphotonmicroscopy:Anemergingtechniqueforintravitalimagingofthetumormicroenvironment.IntraVital.2012;1:60-68.

75. NiemeyerE,KamounWS,HanH-S,HuangY,BhaumikJ,ChenY,GillisenM,MartinJD,RobergeS,LanningRM,CuiJ,MunnLL,NoceraDC,PaderaT,FukumuraD,JainRK,BawendiMG,DunstJ,DudaDG.Multiphotonmicroscopyandin-situlabelingtechniquesallowdetectionofendogenoushematopoeticstemcellsandmeasurementoffunctionalparametersinthestemcellniche.ONKOLOGIE.2013;36:229-230.

76. Qazi,H,PalominoR,ShiZ-D,MunnLL,TarbellJM.CancerCellGlycocalyxMediatesMechanostransductionandFlow-RegulatedInvasion.Integr.Biol.2013;5:1334-43.

77. MunnLL.Dynamicsoftissuetopologyduringcancerinvasionandmetastasis.PhysicalBiology.2013;10(6):065003(13pp).

78. KunertC,BaishJW,LiaoS,PaderaTP,MunnLL.Mechanobiologicaloscillatorscontrollymphflow.ProcNatlAcadSciUSA.2015; 112:10938-43.

79. KunertC,BaishJW,LiaoS,PaderaTP,MunnLL.Nitricoxideregulateslymphaticcontractions.ProcNatlAcadSciUSA.2016.113:E106.

80. KloepperJ,RiedemannL,AmoozgarZ,SeanoG,SusekK,YuV,DalvieN,AmelungRL,DattaM,SongJW,AskoxylakisV,TaylorJW,Lu-EmersonC,BatistaA,KirkpatrickKD,JungK,SnuderlM,MuzikanskyA,


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StubenrauchKG,KrieterO,WakimotoH,XuL,MunnLL,DudaDG,FukumuraD,BatchelorTT,JainRK.Ang-2/VEGFbispecificantibodyreprogramsmacrophagesandresidentmicrogliatoanti-tumorphenotypeandprolongsglioblastomasurvival.ProcNatlAcadSciUSA.2016;113:4476-4481

81. GruionuGG,BazouD,MaimonN,Onita-LencoM,GruionuLG,HuangP,MunnLL.ImplantableTissueIsolationChambersforAnalyzingTumorDynamicsInVivo.LabChip.2016;16:1840-51.

82. QaziH,ShiZD,SongJW,CancelLM,HuangP,ZengY,RobergeS,MunnLL*,TarbellJM.*HeparanSulfateProteoglycansMediateRenalCarcinomaMetastasis.InternationalJournalofCancer.2016;139:2791-2801.*Equalcontributions.

83. BazouD,NgMR,SongJW,ChinSM,MaimonN,MunnLL.Flow-inducedHDAC1phosphorylationandnuclearexportinangiogenicsprouting.ScientificReports.2016a;6:34046.

84. BazouD,MaimonN,GruionuG,MunnLL.Self-assemblyofvascularizedtissuetosupporttumorexplantsinvitro.IntegrativeBiology.2016b;8:1301-11.

85. BaishJW,KunertC,PaderaTP,MunnLL.Synchronizationandrandomtriggeringoflymphaticvesselcontractions.PLOSComputationalBiology.2016;12:e1005231.doi:10.1371/journal.pcbi.1005231.

86. NiaHT,LiuH,SeanoG,DattaM,JonesD,RahbariN,IncioJ,ChauhanVP,JungK,MartinJD,AskoxylakisV,PaderaTP,FukumuraD,BoucherY,HornicekFJ,GrodzinskyAJ,BaishJW,MunnLL,JainRK.Solidstressandelasticenergy:newmeasuresoftumormechanopathology.NatureBiomedicalEngineering.2017;1:0004.

87. GuptaN,BadeauxM,LiuY,NaxerovaK,SgroiD,MunnLL,JainRK,GarkavtsevI.Stressgranule-associatedproteinG3BP2regulatesbreasttumorinitiation.ProcNatlAcadSciUSA. 2016;114:1033-1038.doi:10.1073/pnas.1525387114.

88. KozinSV,MaimonN,WangR,GuptaN,MunnLL,JainRK,GarkavtsevI.Secretoryleukocyteproteaseinhibitor(SLPI)asapotentialtargetforinhibitingmetastasisoftriple-negativebreastcancers.Oncotarget.2017;8(65):108292–108302.

89. BazouD,MaimonN,MunnLL,GonzalezI.EffectsofLowIntensityContinuousUltrasound(LICU)onMousePancreaticTumorExplants.Appl.Sci.2017;7(12)1275;doi:10.3390/app7121275.

90. BoutaEM,BlatterC,RuggieriTA,MeijerEFJ,MunnLL,VakocBJ,PaderaTP.Lymphaticfunctionmeasurementsinfluencedbycontrastagentvolumeandbodyposition.2018;JCIInsight.3(2):e96591.

91. JonesD,MeijerEFJ,BlatterC,LiaoS,PereiraER,BoutaEM,JungK,ChinSM,HuangP,MunnLL,VakocBJ,OttoM,PaderaTP.Methicillin-resistantStaphylococcusaureuscausessustainedcollectinglymphaticvesseldysfunction.2018;ScienceTranslationalMedicine.10(424),eaam7964.OI:10.1126/scitranslmed.aam7964.

92. NiaHT,DattaM,SeanoG,Huang,P,MunnLL,JainRK.Quantifyingsolidstressandelasticenergyfromexcisedorinsitutumors.NatureProtocols.2018;13(5)1091-1105.

93. BazouD,MaimonN,GruionuG,GrahovacJ,SeanoG,LiuH,EvansCL,MunnLL.Vascularbedsmaintainpancreatictumorexplantsforexvivodrugscreening.JournalofTissueEngineeringandRegenerativeMedicine.2018;12(1):e318-e322.

94. SeanoG,Nia,HT,EmblemKE,DattaM,RenJ,KrishnanS,KloepperJ,PinhoMC,HoWW,GhoshM,AskoxylakisV,FerraroGB,RiedemannL,GerstnerER,BatchelorTT,WenPY,LinNU,GrodzinskyAJ,FukumuraD,HuangP,BaishJW,PaderaTP,MunnLL,JainRK.Solidstressinbraintumourscausesneuronallossandneurologicaldysfunctionandcanbereversedbylithium.NatureBiomedicalEngineering2019;3:230-245.

95. LiH,MeiY,MaimonN,PaderaTP,BaishJW,MunnLL.Theeffectsofvalveleafletmechanicsonlymphaticpumpingassessedusingnumericalsimulations.ScientificReports2019;9(1):10649.

96. MoranH,CancelLM,MayerMA,QaziH,MunnLL,TarbellJM.Thecancercellglycocalyxproteoglycanglypican-1mediatesinterstitialflowmechanotransductiontoenhancecellmigrationandmetastasis.Biorheology1-11,2019.

97. VoutouriC,KirkpatrickND,ChungE,MpekrisF,BaishJW,MunnLL,FukumuraD,StylianopoulosT,JainRK.Experimentalandcomputationalanalysesrevealdynamicsoftumorvesselcooptionandoptimaltreatmentstrategies.ProceedingsoftheNationalAcademyofSciences,116:2662-2671,2019.

98. MpekrisF,VoutouriC,BaishJW,DudaDG,MunnLL,StylianopoulosT,JainRK.Combiningmicroenvironmentnormalizationstrategiestoimprovecancerimmunotherapy.ProceedingsoftheNationalAcademyofSciences,117:3728-3737,2020.


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99. NikmaneshiMR,FiroozabadiB,MozafariA,MunnLL.Amulti-scalemodelfordeterminingtheeffectsofpathophysiologyandmetabolicdisordersontumorgrowth.ScientificReports,10(1):3025,2020;doi:10.1038/s41598-020-59658-0.

100. DattaM,NiaH,SeanoG,RobergeS,HuangP,MunnL,JainRK.Invivocompressionandimagingforcausalstudiesofmechanicalforcesinthebrain.Neuro-Oncology2020,22:ii235–ii236.

101. NikmaneshiMR,BFiroozabadiB,MunnLL.Amechanobiologicalmathematicalmodeloflivermetabolism.BiotechnologyandBioengineering2020.117:2861-2874.

102. NiaHT,DattaM,SeanoG,ZhangS,HoWW,RobergeS,HuangP,MunnLL,JainRK.Invivocompressionandimaginginmousebraintomeasuretheeffectsofsolidstress.NatureProtocols2020.15:2321–2340.https://doi.org/10.1038/s41596-020-0328-2.

103. ShigetaK,MatsuiA,KikuchiH,KleinS,MamessierE,ChenIX,AokiS,KitaharaS,InoueK,ShigetaA,HatoT,RamjiawanRR,StaiculescuD,ZopfD,FiebigL,HobbsGS,QuaasA,DimaS,PopescuI,HuangP,MunnLL,CobboldM,GoyalL,ZhuAX,JainRK,DudaDG.RegorafenibcombinedwithPD1blockadeincreasesCD8T-cellinfiltrationbyinducingCXCL10expressioninhepatocellularcarcinoma.JImmunotherCancer2020.8(2):e001435.doi:10.1136/jitc-2020-001435.PMID:33234602;PMCID:PMC7689089.

104. AokiS,InoueK,KleinS,HalvorsenS,ChenJ,MatsuiA,NikmaneshiMR,KitaharaS,HatoT,ChenX,KawakuboK,NiaHT,ChenI,SchanneDH,MamessierE,ShigetaK,KikuchiH,RamjiawanRR,SchmidtTC,IwasakiM,YauT,HongTS,QuaasA,PlumPS,DimaS,PopescuI,BardeesyN,MunnLL,BoradMJ,SassiS,JainRK,ZhuAX,DudaDG.Placentalgrowthfactorpromotestumourdesmoplasiaandtreatmentresistanceinintrahepaticcholangiocarcinoma.Gut2021.gutjnl-2020-322493.

105. VoutouriC,NikmaneshiMR,HardinCC,PatelAB,VermaA,KhandekarMJ,DuttaS,StylianopoulosT,MunnLL,JainRK.InsilicodynamicsofCOVID-19phenotypesforoptimizingclinicalmanagement.ProceedingsoftheNationalAcademyofSciences2021.118:e2021642118.

106. SubudhiS,VermaA,PatelAB,HardinCC,KhandekarMJ,LeeH,McEvoyD,StylianopoulosT,MunnLL,DuttaS,JainRK.ComparingMachineLearningAlgorithmsforPredictingICUAdmissionandMortalityinCOVID-19.NPJDigitalMedicine20214:87.https://doi.org/10.1038/s41746-021-00456-x.

Non-peer reviewed scientific or medical publications/materials in print or other media

Reviews, Chapters and Editorials 1. JainRK,KoenigGC,DellianM,FukumuraD,MunnLL,MelderRJ.Leukocyte-endothelialadhesionand

angiogenesisintumors.CancerandMetastasisReviews1996;15:195-204.2. MelderRJ,KoenigG,MunnLL,JainRK.Adhesionofactivatednaturalkillercellstotumornecrosisfactor-

alpha-treatedendotheliumunderphysiologicalflowconditions.NaturalImmunity1996;15:154-163.3. JainRK,LLMunnLL,FukumuraD,MelderRJ.Invitroandinvivoquantificationofadhesionbetween

leukocytesandvascularendothelium.In:MorganJR,YarmushML,editorsMethodsinMolecularMedicineTotowa,NJ,HumanaPress,Inc1998;18:553-575.

4. JainRK,MunnLL.Leakyvessels?CallAng1!NatureMedicine2000;6:131-2.5. McDonaldD,MunnL,JainR.Vasculogenicmimicry:howconvincing,hownovel,andhowsignificant?

AmericanJournalofPathology2000;156:383-388.6. JainRK,MunnLL,FukumuraD.Transparentwindowmodelsandintravitalmicroscopy:imaginggene

expression,physiologicalfunctionanddrugdeliveryintumors.In:Teicher,B,editorTumorModelsinCancerResearchTotowa,NJ,HumanaPress,Inc2001;pp647-672.

7. JainRK,MunnLL,FukumuraD.Dissectingtumoursusingintravitalmicroscopy.NatureReviewsCancer2002;2:266-276.

8. MunnLL.Aberrantvasculararchitectureintumorsanditsimportanceindrug-basedtherapies.DrugDiscoveryToday2003;8:396-403.

9. JainRK,BrownEB,MunnLL,FukumuraD.Intravitalmicroscopyofnormalanddiseasedtissuesinmice.In:LiveCellImaging-ALaboratoryManual,GoldmanRDandSpectorDL,editors,CSHLPress,ColdSpringHarbor,NY2004;Chapter24,pp435-466.


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10. BrownEB,MunnLL,FukumuraD,JainRK.Apracticalguidetoinvivoimagingoftumors.In:MPLSMLaboratoryManual,ColdSpringHarborLaboratoryPress,ColdSpringHarbor,NY2005;Chapter92,pp695-700.

11. MunnLL.Analyticalapproachestoleukocyte-endotheliuminteractions.In:MicrovascularResearch:BiologyandPathology,SheproD,editorElsevierPress,Amsterdam2005;Chapter117,pp791-794.

12. BockhornM,JainRK,MunnLL.Activeversuspassivemechanismsinmetastasis:docancercellscrawlintovessels,oraretheypushed?LancetOncol2007;8:444–48.

13. JainRK,MunnLL.Vascularnormalizationasarationaleforcombiningchemotherapywithantiangiogenesisagents.Principles&PracticeofOncology2007;21:1-7.

14. MunnLLandJainA.Designandfabricationofmicrofluidicdevicesforflow-basedseparationofbloodcells.Lab-on-a-ChipTechnology(Vol2):BiomolecularSeparationandAnalysis2009Herold,KEandRasooly,A(Eds)CaisterAcademicPress,Norfolk,UKISBN978-1-904455-47-9.

15. JainRK,MunnLL,FukumuraD.TransparentWindowModelsandIntravitalMicroscopy:ImagingGeneExpression,PhysiologicalFunctionandTherapeuticEffectsinTumors.In:TumorModelsInCancerResearch,BeverlyATeicher,edCancerDrugDiscoveryandDevelopment,2011,Part9,641-679,DOI:101007/978-1-60761-968-0_26.

16. BrownE,MunnLL,FukumuraD,JainRK.Invivoimagingoftumors.ColdSpringHarbProtoc,2010:pdbprot5452.

17. FukumuraD,DudaDG,MunnLL,JainRK.Tumormicrovasculatureandmicroenvironment:novelinsightsthroughintravitalimaginginpre-clinicalmodels.Microcirculation2010;17:206-225.

18. MunnLL,Kamoun,W,Dupin,M,TyrrellJA.Modelingstructuralandfunctionaladaptationoftumorvesselnetworksduringanti-angiogenictherapy.ModelingTumorVasculature,TrachetteJackson,ed.,SpringerScience,2011.

19. GoelS,DudaDG,XuL,MunnLL,BoucherY,FukumuraD,JainRK.Normalizationofthevasculaturefortreatmentofcancerandotherdiseases.PhysiolRev2011;91:1071-1121.

20. KozinSV,DudaDG,MunnLL,JainRK.Isvasculogenesiscrucialfortheregrowthofirradiatedtumours?NatRevCancer2011;11:532.

21. MunnLL,KamounWS.LaserScanningMethodologiesforMeasuringRBCVelocity,Flux,HematocritandShearRateinVascularNetworks.TheTextbookofAngiogenesisandLymphangiogenesis:MethodsandApplications.ZudaireEnrique,Cuttitta,F(Eds.)Springer2012,pp417-431.

22. JainRK,MunnLL,FukumuraD.Rabbitearchambers.ColdSpringHarbProtoc.2012Jul1;2012(7):813-14.doi:10.1101/pdb.prot070045.PubMedPMID:22753607.

23. JainRK,MunnLL,FukumuraD.Cornealpocketassayinrabbits.ColdSpringHarbProtoc.2012Sep1;2012(9):1017-8.doi:10.1101/pdb.prot070052.PubMedPMID:22949714.

24. JainRK,MunnLL,FukumuraD.Mammaryfatpadchamberpreparationinmice.ColdSpringHarbProtoc.2012Oct1;2012(10):1113-4.doi:10.1101/pdb.prot071506.PubMedPMID:23028075.

25. JainRK,MunnLL,FukumuraD.Mammaryfatpadtumorpreparationinmice.ColdSpringHarbProtoc.2012Oct1;2012(10):1115-6.doi:10.1101/pdb.prot071514.PubMedPMID:23028076.

26. JainRK,MunnLL,FukumuraD.Lymphangiographyofthemousetail.ColdSpringHarbProtoc.2012Nov1;2012(11):1177-8.doi:10.1101/pdb.prot072108.PubMedPMID:23118364.

27. JainRK,MunnLL,FukumuraD.Lymphangiographyofthemouseear.ColdSpringHarbProtoc.2012Nov1;2012(11):1179-80.doi:10.1101/pdb.prot072116.PubMedPMID:23118365.

28. JainRK,MunnLL,FukumuraD.Pancreatictumorpreparationinmice.ColdSpringHarbProtoc.2012Dec1;2012(12).doi:pii:pdb.prot072363.10.1101/pdb.prot072363.PubMedPMID:23209145.

29. JainRK,MunnLL,FukumuraD.Livertumorpreparationinmice.ColdSpringHarbProtoc.2012Dec1;2012(12).doi:pii:pdb.prot072371.10.1101/pdb.prot072371.PubMedPMID:23209146.

30. JainRK,MunnLL,FukumuraD.Lungwindowpreparationinmice.ColdSpringHarbProtoc.2013Jan1;2013(1).doi:pii:pdb.prot072678.10.1101/pdb.prot072678.PubMedPMID:23282642.

31. JainRK,MunnLL,FukumuraD.MeasuringInterstitialDiffusion,Convection,andBindingParametersinMouseTumors.ColdSpringHarbProtoc.2013,2013(7).

32. JainRK,MunnLL,FukumuraD.MeasuringInterstitialpHandpO2inMouseTumors.ColdSpringHarbProtoc.2013,2013(7).


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33. JainRK,MunnLL,FukumuraD.MeasuringLeukocyte-EndothelialInteractionsinMice.ColdSpringHarbProtoc.2013,2013(6).

34. JainRK,MunnLL,FukumuraD.MeasuringVascularPermeabilityinMice.ColdSpringHarbProtoc.2013,2013(5).

35. JainRK,MunnLL,FukumuraD.Measuringangiogenesisandhemodynamicsinmice.ColdSpringHarbProtoc.2013,2013(4).

36. DudaDG,MunnLL,JainRK.CanWeIdentifyPredictiveBiomarkersforAntiangiogenicTherapyofCancerUsingMathematicalModeling?JNCI2013105:762-765.

37. MunnLL,KunertC,TyrrellJA.ModelingTumorBloodVesselDynamics.inMathematicalMethodsandModelsinBiomedicine--LectureNotesonMathematicalModellingintheLifeSciences,UrszulaLedzewicz,HeinzSchättler,AvnerFriedman,EugeneKashdaned.2013,pp117-147.

38. KeslerCT,LiaoS,MunnLL,PaderaTP.Lymphaticvesselsinhealthanddisease.WileyInterdisciplinaryReviews:SystemsBiologyandMedicine,2013.

39. ChauhanVP,BoucherY,FerroneCR,RobergeS,MartinJD,StylianopoulosT,BardeesyN,DePinhoRA,PaderaTP,MunnLL,JainRK.Compressionofpancreatictumorbloodvesselsbyhyaluronaniscausedbysolidstressandnotinterstitialfluidpressure.CancerCell2014,26(1):14-15.

40. MunnLL,PaderaTP.Imagingthelymphaticsystem.MicrovascularResearch2014:55-63.41. SongJW,BazouD,MunnLL.MicrofluidicModelofAngiogenicSprouting.InVascularMorphogenesis,

Springer,NY.(2015)pp243-254.42. King-,ReinhartMunnLJanmeyP,FletcherD,GerechtS,LevineR,MallickP,McCartyO, C.PhysicalSciences

andEngineeringAdvancesinLifeSciencesandOncology:AWTECGlobalAssessment.Springer,Nov19,2015403pages- .

43. MunnLL.Mechanobiologyoflymphaticcontractions.SeminarsinCell&DevelopmentalBiology.2015Elsevier,38:67-74.

44. MunnLL.FluidMechanicsandTransportinTumors.PhysicalSciencesandEngineeringAdvancesinLifeSciencesandOncology.PartoftheseriesSciencePolicyReports,2016;pp73-88.

45. PaderaTP,MeijerEFJ,MunnLL.TheLymphaticSysteminDiseaseProcessesandCancerProgression.Annu.Rev.Biomed.Eng.(2016)18:125–58.

46. MunnLL,JainRK.TheForcesofCancer.TheScientist.2016;30:52-57.47. MunnLL.CancerandInflammation.WIREsSystemsBiologyandMedicine.2017;9:e1370

doi:10.1002/wsbm.1370.48. StylianopoulosT,MunnLL,JainRK.ReengineeringthePhysicalMicroenvironmentofTumorstoImprove

DrugDeliveryandEfficacy:FromMathematicalModelingtoBenchtoBedside.TrendsinCancer.2018;4(4):292-319.

49. StylianopoulosT,MunnLL,JainRK.ReengineeringtheTumorVasculature:ImprovingDrugDeliveryandEfficacy.TrendsinCancer.2018;4(4):258-59.

50. MunnLL,GarkavtsevI.SLPI:anewtargetforstoppingmetastasis.Aging.2018;10(1):13–14.51. Nowak-SliwinskaP,AlitaloK,AllenE,AnisimovA,AplinAC,AuerbachR,AugustinHG,BatesDO,Van

BeijnumJR,BenderRHF,BergersG,BikfalviA,BischoffJ,BöckBC,BrooksPC,BussolinoF,CakirB,CarmelietP,CastranovaD,CimpeanAM,CleaverO,CoukosG,DavisGE,DePalmaM,DimbergA,DingsRPM,DjonovV,DudleyAC,DuftonNP,FendtS-M,FerraraN,FruttigerM,FukumuraD,GhesquièreB,GongY,GriffinRJ,HarrisAL,HughesCCW,HultgrenNW,Iruela-ArispeML,IrvingM,JainRK,KalluriR,KaluckaJ,KerbelRS,KitajewskiJ,KlaassenI,KleinmannHK,KoolwijkP,KuczynskiE,KwakBR,MarienK,Melero-MartinJM,MunnLL,NicosiaRF,NoelA,NurroJ,OlssonA-K,PetrovaTV,PietrasK,PiliR,PollardJW,PostMJ,QuaxPHA,RabinovichGA,RaicaM,RandiAM,RibattiD,RueggC,SchlingemannRO,Schulte-MerkerS,SmithLEH,SongJW,StackerSA,StalinJ,StratmanAN,VanDeVeldeM,VanHinsberghVWM,VermeulenPB,WaltenbergerJ,WeinsteinBM,XinH,Yetkin-ArikB,Yla-HerttualaS,YoderMC,GriffioenAW.Consensusguidelinesfortheuseandinterpretationofangiogenesisassays.Angiogenesis.2018;21(3):425–532.DOI:10.1007/s10456-018-9613-x.

52. NiaHT,MunnLL,JainRK,Mappingphysicaltumormicroenvironmentanddrugdelivery.ClinicalCancerResearch.2019,clincanres.3724.2018.

53. MunnLL,JainRK.Vascularregulationofanti-tumorimmunity.Science365:544-545,2019.DOI:10.1126/science.aaw7875.


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54. MunnLLandNiaHT.Mechanosensingtensilesolidstresses.ProceedingsoftheNationalAcademyofSciences,116:21960-21962,2019.

55. NiaHT,MunnLL,JainRK.Physicaltraitsofcancer.Science,370,2020.56. MunnLL,StylianopoulosT,JainNK,HardinCC,KhandekarMJ,JainRK.VascularNormalizationtoImprove

TreatmentofCOVID-19:LessonsfromTreatmentofCancer.ClinCancerRes2021.DOI:10.1158/1078-0432.CCR-20-4750.

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Date Prepared: July 8, 2021