Cystic FibrosisCystic Fibrosis

Ventura Simmons1/29/2010Period: 6/7

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Summary Cystic Fibrosis mainly affects 2 of our many

systems: -Respiratory, and -Digestive In these systems our airways, lungs

(respiratory), stomach, colon, and intestines (digestive)

These organs are affected by this disease because Cystic Fibrosis causes a change in the properties of the mucus that coats the inside of these organs, and this mucus aids the organs in surviving without it it’d be a lot like a teenager without electronics.

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Chromosome 7

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RecessiveRecessive This Disease is Autosomal Recessive meaning

you need to get the gene from both parents to obtain it fully just like blue eyes you need a blue eye gene from both parents to have blue eyes so if both parents have blue eyes you will just like if both parents have Cystic Fibrosis their child will.

The opposite of recessive, dominant is GOOD,but if you have one dominant than you have 1 contaminated allele a.k.a your in trouble.

In Autosomal Recessive the word Autosomal refers to the gene dealing with and autosome which is a cell that isn't a sex cell and autosome deals with sex cells but it is a somatic cell.

AlleleDefinition: An allele is an alternative form of a gene (one member of a pair) that is located at a specific

position on a specific chromosome.C- For my slide show this will be considered the

recessive allele which mean that if a child has this as one of its two alleles then they will most definitely carry

the disease weather it is fully or half way.F- I used a F for my dominant allele and if u have two

dominant that is good because then you are completely healthy but only one wont cut it. So the more F’s the

better.FF would be homozygous dominant meaning 2 of the same

dominantFC is heterozygous dominant meaning 1 dominant and 1

recessive Lastly CC which is homozygous recessive meaning it has 2

of the same recessive alleles.

•homozygous dominant•heterozygous dominant•homozygous recessive

Punnett Squares

F C

F FF FC

C FC CC

C C

F FC FC

C CC CC

C C

F FC FC

F FC FC

Punnett SquarePunnett Square

Ratios

Percentages 1 : 2 : 11FF : 2FC : 1CC

25% : 50% : 25%25%FF : 50%FC : 25%CC

homozygous dominant:heterozygous dominant:homozygous recessive

homozygous dominant:heterozygous dominant:homozygous recessive

F C

F FF FC

C FC CC

Pheno and Genotype

•The F is the dominant allele and C is the recessive allele

•Phenotype

CC= carrier and victimFC= just carrierFF= completely healthy

•GenotypeFF= Homozygous dominantFC= Heterozygous dominantCC= homozygous recessive

F C

F FF FC

C FC CC

Phenotype Genotype

Explain Genotype and Phenotype probability using:

•Phenotype -Ratios- 3 : 1- Percentages- 75% : 25%

Phenotype deals with which possibilities have the dominant alleles against the ones that don’t have any dominant alleles

•Genotype- Ratios- 1FF : 2 FC : 1 CC - Percentages- 25% FF: 50% FC : 25%CC

Genotype shows the probably for ALL the allele combo’s so FF, FC, and CC would all be classified separately.

F C

F FF FC

C FC CC

Student Practice

Genotype:Ratio: 3:1

Percentage: 75% yes 25% no

Phenotype:Ratio: 1:2:1

Percentage: 25% NO50% carrier 25% YES

FF

F

F

C

FC

CFC CC

Pedigree

Square: Male Circle: Female

Orange: Full on disease Half: Only Carrier

Blue: No disease at all

Student Practice

Square: Male Circle: Female

Orange: Full on disease

Half: Only CarrierBlue: No disease at all

1. What 2 other possibilities of children could the first couple have?

2. What kind of husband would the center circle have to marry to have a healthy son.

3. If the first mother had a child with her son in law what would be her chances of having a healthy child