COREY R. DEEKEN, PH.D., E.I.T. COVALENT BIO, LLC

69 HIGH TRAILS DRIVE EUREKA, MO 63025

(417) 844-3002 DEEKENC@COVALENTBIOLLC.COM

WWW.COVALENTBIOLLC.COM

EMPLOYMENT HISTORY: Current Employer:

Covalent Bio, LLC (Eureka, MO)

2015-present Principal

Past Academic Appointments:

Section of Minimally Invasive Surgery, Department of Surgery Washington University School of Medicine (St. Louis, Missouri)

2009-2015 Director of the Biomedical Engineering and Biomaterials Laboratory 2009-2014 Instructor of Surgery 2014-2015 Assistant Professor of Surgery (primary appointment)

Department of Mechanical Engineering & Materials Science Washington University (St. Louis, Missouri)

2014-2015 Assistant Professor (joint appointment)

CAREER STATEMENT: Principal consultant with 10 years of experience developing novel biomaterials, large animal models for soft tissue repair, and techniques for assessing explanted materials. Extensive background in materials characterization techniques including comprehensive evaluation of over 40 types of hernia repair materials. Experienced technical writer of 45 publications and book chapters and over 70 grant proposals.

ACADEMIC QUALIFICATIONS: Doctor of Philosophy - Biological Engineering University of Missouri (Columbia, Missouri) 2008

Dissertation: “Design and development of bionanocomposite materials comprised of acellular porcine diaphragm tendon and functionalized nanomaterials” Bachelor of Science - Biological Engineering University of Missouri (Columbia, Missouri) 2005

AREAS OF EXPERTISE:

Biomaterials

Hernia repair

Large animal surgical models o Ventral hernia repair o Adhesion characteristics

Histology o Explanted materials o Host tissue response

Mechanical testing o Uniaxial tensile testing o Biaxial testing o Ball burst testing o Suture retention testing

Tear resistance testing

Scanning electron microscopy

Design of novel biomaterials o Nanomaterials o Electrospinning

PROFESSIONAL SKILLS:

Medical & technical writing

Statistical analysis

Literature review

Study design

Protocol development

Interpretation of data

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Fellowship Training: Department of Biological Engineering University of Missouri (Columbia, Missouri)

2005-2006 National Science Foundation Grades K-12 Teaching Fellow Department of Biological Engineering University of Missouri (Columbia, Missouri)

2006-2008 National Science Foundation Graduate Research Fellow

AFFILIATIONS:

Professional Societies: American Hernia Society

2005-present Member Biomedical Engineering Society

2005-present Member Institute of Biological Engineering

2005-present Member Society of American Gastrointestinal and Endoscopic Surgeons

2009-present Member Society for Biomaterials

2009-present Member Americas Hernia Society Quality Collaborative

2014-present Publications Committee Chair Washington University Affiliations:

2009-2015 Digestive Diseases Research Core Centers, Associate Member 2009-2015 Institute of Clinical and Translational Sciences, Member 2014-2015 Center for Regenerative Medicine, Member

Washington University Committees:

Department of Biomedical Engineering Washington University (St. Louis, Missouri) 2011 Qualifying Examination Committee (PhD student: Thomas Wilems)

Washington University School of Medicine 2014-2015 Clinical Representative to the Executive Committee of the Faculty

Council

PROFESSIONAL REGISTRATION: 2005 Fundamentals of Engineering Examination, passed

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PATENTS: 1. SA Grant, CR Costello, BJ Ramshaw, SL Bachman, A. Ramaswamy, NM Fearing.

Bionanocomposite for Tissue Regeneration and Soft Tissue Repair. Provisional patent application submitted on 09-21-07 to the U.S. Patent & Trademark Office. UMC Docket No. 07UMC092

PUBLICATIONS:

Peer-reviewed Journal Articles:

1. Saettele TM, Bachman SL, Costello CR, Grant SA, Cleveland DS, Loy TS, Kolder DG,

Ramshaw BJ Use of porcine dermal collagen as a prosthetic mesh in a contaminated field for ventral hernia repair: A case report. Hernia (2007) June;11(3):279-285 PubMed PMID: 17279319

2. Costello CR, Bachman SL, Grant SA, Cleveland DS, Loy TS, Ramshaw BJ

Characterization of heavyweight and lightweight polypropylene prosthetic mesh explants from a single patient. Surg Innov (2007) Sept;14(3):168-176 PubMed PMID: 17928615

3. Costello CR, Bachman SL, Ramshaw BJ, Grant SA Materials characterization of explanted

polypropylene hernia meshes. J of Biomed Mater Res Part B (2007) Oct;83B(1):44-49 PubMed PMID: 17285608

4. Jenkins ED, Melman L, Frisella MM, Deeken CR, Matthews BD Evaluation of acute fixation

strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant. Hernia (2010)Oct;14(5):505-509 PubMed PMID: 20454989

5. Jenkins ED, Melman L, Deeken CR, Greco SC, Frisella MM, Matthews BD Evaluation of

fenestrated and non-fenestrated biologic grafts in a porcine model of mature ventral incisional hernia repair. Hernia (2010) Dec;14(6):599-610 PubMed PMID: 20549274

6. Melman L, Jenkins ED, Deeken CR, Brodt MD, Brown SR, Brunt LM, Eagon JC, Frisella

MM, Matthews BD Evaluation of acute fixation strength for mechanical tacking devices and fibrin sealant versus polypropylene suture for laparoscopic ventral hernia repair. Surg Innov (2010) Dec;17(4):285-290 PubMed PMID: 20817641

7. Jenkins ED, Melman L, Desai S, Brown SR, Frisella MM, Deeken CR, Matthews BD Evaluation of intraperitoneal placement of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant in a New Zealand White rabbit model. Surg Endosc (2011) Feb; 25(2):604-612 PubMed PMID: 20652323

8. Deeken CR, Esebua M, Bachman SL, Ramshaw BJ, Grant SA Assessment of the

biocompatibility of two novel, bionanocomposite scaffolds in a rodent model. J Biomed Mater Research: Part B (2011) Feb; 96B(2):351-359 PubMed PMID: 21210419

9. Deeken CR, White AK, Bachman SL, Ramshaw BJ, Cleveland DS, Loy TS, Grant SA

Method of preparing a decellularized porcine tendon using tributyl phosphate. J Biomed Mater Research: Part B (2011) Feb;96B(2):199-206 PubMed PMID: 21210498

10. Deeken CR, Abdo MS, Frisella MM, Matthews BD Physicomechanical evaluation of

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absorbable and nonabsorbable barrier composite meshes for laparoscopic ventral hernia repair. Surg Endosc (2011) 25:1541-1552 PubMed PMID: 20976479

11. Deeken CR, Abdo MS, Frisella MM, Matthews BD Physicomechanical evaluation of

polypropylene, polyester, and polytetrafluoroethylene meshes for inguinal hernia repair. J Am Coll Surg (2011) Jan; 212(1):68-79 PubMed PMID: 21115372

12. Brown SR, Melman L, Jenkins ED, Deeken CR, Frisella MM, Brunt LM, Eagon JC,

Matthews BD Collagen type I:III ratio of the gastroesophageal junction in patients with paraesophageal hernias. Surg Endosc (2011) 25:1390-1394 (PMCID: PMC3785291)

13. Deeken CR, Cozad MJ, Bachman SL, Ramshaw BJ, Grant SA Characterization of

bionanocomposite scaffolds comprised of amine-functionalized single-walled carbon nanotubes crosslinked to an acellular porcine tendon. J Biomed Mater Research: Part A (2011) Mar; 96(3)584-594 PubMed PMID: 21254390

14. Deeken CR, Fox DB, Bachman SL, Ramshaw BJ, Grant SA Characterization of

bionanocomposite scaffolds comprised of amine-functionalized gold nanoparticles and silicon carbide nanowires crosslinked to an acellular porcine tendon. J Biomed Mater Research: Part B (2011) May; 97B: 334-344 PubMed PMID: 21394904

15. Jenkins ED, Melman L, Deeken CR, Greco SC, Frisella MM, Matthews BD Biomechanical and histological evaluation of fenestrated and non-fenestrated biologic mesh in a porcine model of ventral hernia repair. J Am Coll Surg (2011) Mar; 212(3)327-399 (PMCID: PMC3783002)

16. Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt MD, Deeken CR, Greco SC,

Frisella MM, Matthews BD Early biocompatibility of crosslinked and non-crosslinked biologic meshes in a porcine model of ventral hernia repair. Hernia (2011) 15(2):157-164 (PMCID: PMC3783088)

17. Deeken CR, Melman L, Jenkins ED, Greco SC, Frisella MM, Matthews BD Histologic and

biomechanical evaluation of crosslinked and non-crosslinked biologic meshes in a porcine model of ventral hernia repair. J Am Coll Surg (2011) 212(5): 880-888 (PMCID: PMC3782991)

18. Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt MD, Deeken CR, Greco SC,

Frisella MM, Matthews BD Histologic and biomechanical evaluation of a novel macroporous PTFE knit mesh compared to lightweight and heavyweight polypropylene mesh in a porcine model of ventral hernia repair. Hernia (2011)15(4):423-431 PubMed PMID: 21279663

19. Jenkins ED, Lerdsirisopon S, Costello KP, Melman L, Greco SC, Frisella MM, Matthews BD, Deeken CR Laparoscopic fixation of biologic mesh at the hiatus with fibrin or polyethylene glycol (PEG) sealant in a porcine model. Surg Endosc (2011)25;10: 3405-3413 PubMed PMID: 21594740

20. Eliason BJ, Frisella MM, Matthews BD, Deeken CR Effect of repetitive loading on the

mechanical properties of synthetic hernia repair materials. J Am Coll Surg 2011 Sept;213(3)430-435 PubMed PMID: 21705242

21. Jenkins ED, Melman L, Desai S, Deeken CR, Greco SC, Frisella MM, Matthews BD

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Histologic evaluation of absorbable and nonabsorbable barrier coated mesh secured to the peritoneum with fibrin sealant in a New Zealand White rabbit model. Hernia (2011) Dec;15(6):677-684 PubMed PMID: 21607571

22. Lerdsirisopon S, Frisella MM, Matthews BD, Deeken CR Biomechanical evaluation of

potential damage to hernia repair materials due to fixation with helical titanium tacks. Surg Endosc (2011) 25(12):3890-3897 PubMed PMID: 21751059

23. Deeken CR, Melman L, Jenkins ED, Greco SC, Frisella MM, Matthews BD Reply to comments regarding: Histologic and biomechanical evaluation of crosslinked and non-crosslinked biologic meshes in a porcine model of ventral hernia repair. J Am Coll Surg (2011) 213: 692

24. Deeken CR, Matthews BD Comparison of contracture, adhesion, tissue ingrowth, and

histologic response characteristics of permanent and absorbable barrier meshes in a porcine model of laparoscopic ventral hernia repair. Hernia (2012)16(1):69-76 PubMed PMID: 21748478

25. Deeken CR, Faucher KM, Matthews BD A review of the composition, characteristics, and effectiveness of barrier mesh prostheses utilized for laparoscopic ventral hernia repair. Surg Endosc (2012) 26:566-575 PubMed PMID: 21898010

26. Deeken CR, Bachman SL, Ramshaw BJ, Grant SA Characterization of bionanocomposite

scaffolds comprised of mercaptoethylamne-functionalized gold nanoparticles crosslinked to acellular porcine tissue. J Mater Sci: Mater Med (2012) 23:537-546 PubMed PMID: 22071985

27. Deeken CR, Eliason BJ, Pichert MD, Grant SA, Frisella MM, Matthews BD Differentiation

of biologic scaffold materials through physicomechanical, thermal, and enzymatic degradation techniques. Annals of Surgery (2012)255(3):595-604 PubMed PMID: 22314328

28. Pui CL, Tang ME, Annor AH, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect

of repetitive loading on the mechanical properties of biological scaffold materials. J Am Coll Surg (2012) 215:216-228 PubMed PMID: 22521670

29. Ebersole GC, Buettmann EG, MacEwan MR, Tang ME, Frisella MM, Matthews BD, Deeken CR Development of novel electrospun absorbable polycaprolactone (PCL)

scaffolds for hernia repair applications. Surg Endosc (2012) 26:2717-2728 PubMed PMID: 22538673.

30. Annor AH, Tang ME, Pui CL, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect of enzymatic degradation on the mechanical properties of biological scaffold materials. Surg Endosc (2012) 26:2767-2778 (PMCID: PMC3702043)

31. Grant SA, Deeken CR, Hamilton SR, Grant DA, Bachman SL, Ramshaw BJ. A

comparative study of the remodeling and integration of a novel AuNP-tissue scaffold and commercial tissue scaffolds in a porcine model. J Biomed Mater Res A. 2013 Oct; 101(10):2778-2787 PubMed PMID: 23436761

32. Cavallo JA, Greco SC, Liu J, Frisella MM, Deeken CR, Matthews BD Remodeling

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characteristics and biomechanical properties of a crosslinked versus a non-crosslinked porcine dermis scaffolds in a porcine model of ventral hernia repair. Hernia (e-pub 01 March 2013) doi 10.1007/s10029-013-1070-2 PubMed PMID: 23483265

33. Deeken CR, Matthews BD Characterization of the mechanical strength, resorption

properties, and histologic characteristics of a fully absorbable material (Poly-4-hydroxybutyrate-PHASIX Mesh) in a porcine model of hernia repair. ISRN Surg,Vol 2013, pages 1-12, article ID 238067. PMCID: PMC3679684

34. Deeken CR, Matthews BD Ventralight ST & SorbaFix vs. Physiomesh & Securestrap in a

porcine model. JSLS (2013)17:549-559. PubMed PMID: 24398196

35. Cavallo JA, Roma AA, Jasielec MS, Ousley J, Creamer J, Pichert MD, Baalman S, Frisella MM, Matthews BD, Deeken CR Remodeling characteristics and collagen distribution in

biological scaffold materials explanted from human subjects after abdominal soft tissue reconstruction. Annals of Surgery; e-pub 26 Dec 2013

36. Cavallo JA, Roma AA, Jasielec MS, Ousley J, Creamer J, Pichert MD, Baalman S, Frisella

MM, Matthews BD, Deeken CR Remodeling characteristics and collagen distribution in synthetic mesh materials explanted from human subjects after abdominal soft tissue reconstruction: An analysis of remodeling characteristics by patient risk factors and surgical site classifications. Surgical Endoscopy; 2014 28(6):1852-1865

37. Deeken CR, Thompson Jr. DM, Castile RM, Lake SP Biaxial analysis of synthetic scaffolds

for hernia repair demonstrates variability in mechanical anisotropy, non-linearity and hysteresis. JMBBM; 2014 38:6-16

38. Myckatyn TM, Cavallo JA, Sharma K, Gangopadhyay N, Dudas J, Roma AA, Baalman S, Tenenbaum MM, Matthews BD, Deeken CR The impact of chemotherapy and radiation on

the remodeling of acellular dermal matrices in staged, prosthetic breast reconstruction. Plast Reconstr Surg (2015) Jan;135(1):43e-57e.

39. Zihni AM, Cavallo JA, Thompson Jr DM, Chowdhury NH, Frisella MM, Matthews BD, Deeken CR Evaluation of absorbable mesh fixation devices at various deployment angles.

Hernia e-pub 08 Oct 2014

40. Ward KC, Costello KP, Baalman S, Pierce RA, Deeken CR, Frisella MM, Brunt LM,

Matthews BD Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair. Surg Endosc e-pub 18 Oct 2014

41. Lake SP, Ray S, Zihni AM, Thompson Jr DM, Gluckstein J, Deeken CR Pore size and pore shape – but not mesh density – alter the mechanical strength of tissue ingrowth and host tissue response to synthetic mesh materials in a porcine model of ventral hernia repair. JMBBM 42 (2014) 186-197.

Submitted Articles:

1. Gretsch KF, Lather HD, Peddada KV, Wall L, Deeken CR, Goldfarb CA Development of novel 3D-printed robotic prosthetic for transradial amputees Accepted for publication in Prosthetic & Orthotics International.

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2. Cavallo JA, Gangopadhyay N, Dudas J, Roma AA, Jasielec MS, Baty J, Baalman S, Frisella MM, Tenenbaum MM, Myckatyn TM, Matthews BD, Deeken CR. Remodeling characteristics and collagen distributions of biologic scaffold materials biopsied from postmastectomy breast reconstruction sites. Accepted for publication in Annals of Plastic Surgery.

3. Poppler L, Cohen J, Dolen UC, Schriefer AE, Tenenbaum MM, Deeken CR, Chole RA,

Myckatyn TM. Microscopic, molecular and clinical evaluation of capsules and acellular dermal matrices for bacteria. Accepted for publication in Aesthetic Surgery Journal.

Book Chapters: 1. Cavallo, JA, Deeken, CR, Matthews, BD. In B. Jacob & B. Ramshaw (Eds.), Biologic Mesh:

When and Why: A Critical Appraisal The SAGES Manual of Hernia Repair. Springer

Publishing Company; 2013

2. Deeken CR. In B. Heniford & Y. Novitsky (Eds.), Biologic mesh: classification and evidence-based critical appraisal in Current Principles of Surgery of the Abdominal Wall. Springer

Publishing Company; 2015

PRESENTATIONS: Invited Faculty 1. Deeken CR Mesh update – Where’s the values? Biologics. Americas Hernia Society

annual meeting in Orlando, Florida, March 13-16, 2013 2. Deeken CR Characterization of hernia repair materials and predictability of clinical

performance. Department of Mechanical Engineering & Materials Science colloquium series at Washington University in St. Louis (St. Louis, MO) January 23, 2014

3. Deeken CR Preclinical evaluation of biomaterials: Material characterization and

predictability of clinical performance. 16th Annual Hernia Repair of the Americas Hernia Society meeting in Las Vegas, NV, March 13, 2014

International Conferences:

1. Bachman, SL, Costello CR, Cleveland DS, Davis JW, Christiansen DL, Loy TS, Grant SA

Ramshaw BJ The relationship of patient characteristics to materials analysis in explanted polypropylene hernia meshes from 23 human subjects. Hernia Repair 2007, 10th Anniversary Hernia Congress, Hollywood, FL, Mar. 2007 and the 29th International Congress of the European Hernia Society, Athens, Greece, May 2007

2. Bachman SL, Cleveland DS, Costello CR, Loy TS, Grant SA, Ramshaw BJ Bridging the

gap: Use of porcine small intestine submucosa mesh for laparoscopic ventral hernia repair in a porcine model with varying defect sizes. 29th International Congress of the European Hernia Society, Athens, Greece, May 2007

3. Jenkins ED, Melman L, Deeken CR, Brodt MD, Frisella MM, Matthews BD Evaluation of

fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant. European Hernia Society, Berlin, Germany, September 10, 2009

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4. Jenkins ED, Melman L, Deeken CR, Brodt MD, Frisella MM, Matthews BD Evaluation of fenestrated and nonfenestrated biologic mesh materials in a porcine model of mature ventral incisional hernia repair. European Hernia Society, Berlin, Germany, September 10, 2009

5. Melman L, Jenkins ED, Brodt MD, Deeken CR, Frisella MM, Matthews BD Evaluation of

acute fixation strength for mechanical tacking and fibrin sealant versus polypropylene suture for laparoscopic ventral hernia repair. European Hernia Society, Berlin, Germany, September 10, 2009

6. Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt M, Deeken CR, Frisella MM, Matthews BD Evaluation of crosslinked and non-crosslinked biologic mesh in a porcine model of ventral hernia repair. European Hernia Society, Berlin, Germany, September 10, 2009

National Conferences: 1. Costello CR, Bachman SL, Ramshaw BJ, Grant SA Polypropylene hernia mesh materials:

An in-depth materials analysis of explanted specimens. Institute of Biological Engineering Annual Meeting, St. Louis, MO, Mar. 2007

2. Costello CR, Bachman SL, Ramshaw BJ, Grant SA Heavyweight polypropylene mesh—

inert? Maybe not: An in-Depth materials analysis of explanted specimens. Hernia Repair 2007, 10th Anniversary Hernia Congress, Hollywood, FL, Mar. 2007

3. Costello CR, Fox DB, Bachman SL, Ramshaw BJ, Grant SA Acellular porcine tissue

crosslinked with functionalized nanomaterials: Novel bionanocomposite scaffolds for soft tissue repair applications. Institute of Biological Engineering Annual Meeting, Chapel Hill, NC, March 6-9, 2008

4. White AK, Emerick E, Costello CR, Grant SA Investigative study of long-term packaging

effects on acellular dermis scaffolds. Institute of Biological Engineering Annual Meeting, Chapel Hill, NC, March 6-9, 2008

5. Jenkins ED, Melman L, Brown SR, Frisella MM, Deeken CR, Matthews BD Evaluation of

fenestrated and nonfenestrated biologic mesh materials in a porcine model of mature ventral incisional hernia repair. Hernia Repair 2010, American Hernia Society, Orlando, Florida, March 18, 2010

6. Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt M, Deeken CR, Frisella MM,

Matthews BD Histologic evaluation of a novel macroporous PTFE knit mesh compared to lightweight and heavyweight polypropylene meshes in a porcine model of ventral incisional hernia repair. Hernia Repair 2010, American Hernia Society, Orlando, Florida, March 18, 2010

7. Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt M, Deeken CR, Frisella MM,

Matthews BD Histologic evaluation of crosslinked and non-crosslinked biologic mesh materials in a porcine model of mature ventral incisional hernia repair. Hernia Repair 2010, American Hernia Society, Orlando, Florida, March 19, 2010

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8. Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt M, Deeken CR, Frisella MM,

Matthews BD Biomechanical evaluation of a novel macroporous PTFE knit mesh compared to lightweight and heavyweight polypropylene meshes in a porcine model of mature ventral incisional hernia repair. Hernia Repair 2010, American Hernia Society, Orlando, Florida, March 19, 2010

9. Deeken CR, Abdo MS, Frisella MM, Matthews, BD Physicomechanical evaluation of

“lightweight” polypropylene, polyester, and polytetrafluoroethylene meshes for inguinal hernia repair. Hernia Repair 2010, American Hernia Society, Orlando, Florida, March 19, 2010

10. Jenkins ED, Melman L, Desai S, Brown SR, Frisella MM, Deeken CR, Matthews BD

Evaluation of intraperitoneal placement of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant (New Zealand White rabbit model). Society of American Gastrointestinal and Endoscopic Surgeons meeting, National Harbor, MD, April 14-17, 2010

11. Brown SR, Melman L, Jenkins ED, Deeken CR, Frisella MM, Brunt LM, Eagon JC,

Matthews BD Collagen type I/III ratio in the supporting ligaments of the gastroesophageal junction in patients with paraesophageal hernias. Society of American Gastrointestinal and Endoscopic Surgeons meeting, National Harbor, MD, April 14-17, 2010

12. Grant SA, Deeken CR, Grant DA, Bachman SL, Ramshaw BJCharacterization and in vivo

studies of a novel bionanocomposite as a tissue scaffold. Society for Biomaterials Annual Meeting, Seattle, WA, April 21-24, 2010

13. Deeken CR, Matthews BD Comparison of adhesion and contracture characteristics of

permanent and absorbable barrier mesh products following implantation/fixation with mechanical absorbable fixation in a porcine model of simulated laparoscopic ventral hernia repair. 19th Society for Laparoendoscopic Surgeons Annual Meeting, New York, New York, Sept. 2010

14. Deeken CR, Eliason BJ, Pichert MD, Grant SA, Frisella MM, Matthews BD

Characterization of the physicomechanical, thermal, and degradation properties of biologic scaffold materials utilized for hernia repair applications. Hernia Repair 2011, American Hernia Society, San Francisco, California, March 16, 2011

15. Cavallo JA, Deeken CR, Melman L, Jenkins ED, Frisella MM, Matthews BD Biomechanical

properties of the porcine abdominal wall repaired with crosslinked versus non-crosslinked porcine dermis in a porcine model of ventral hernia repair. Hernia Repair 2011, American Hernia Society, San Francisco, California, March 18, 2011

16. Jenkins ED, Lerdsirisopon S, Costello KP, Melman L, Greco SC, Frisella MM, Matthews

BD, Deeken CR Laparoscopic fixation of biologic mesh at the hiatus with fibrin or

polyethylene glycol (PEG) sealant in a porcine model. Society of American Gastrointestinal and Endoscopic Surgeons meeting, San Antonio, Texas, April 1, 2011

17. Cavallo JA, Roma AA, Schwander K, Pichert MD, Gray EK, Baalman S, Frisella MM,

Deeken CR, Matthews BD Remodeling characteristics and collagen distribution in biologic scaffold materials explanted from human subjects after abdominal wall reconstruction: An analysis of scaffold remodeling by host characteristics and surgical site classification. 2012

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Academic Surgical Congress, Las Vegas, Nevada, February 2012 18. Annor AH, Tang ME, Pui CL, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect

of enzymatic degradation on the mechanical properties of biologic scaffold materials. Society of American Gastrointestinal and Endoscopic Surgeons meeting, San Diego, California, March 8, 2012

19. Ebersole GC, Buettmann EG, MacEwan MR, Tang ME, Frisella MM, Matthews BD,

Deeken CR Development of novel electrospun absorbable polycaprolactone (PCL) scaffolds for hernia repair applications. Society of American Gastrointestinal and Endoscopic Surgeons meeting, San Diego, California, March 9, 2012

20. Deeken CR, Matthews BD Characterization of the mechanical strength and resorption

properties of a novel fully absorbable material (PhasixTM) in a porcine model of hernia repair. Presented at the American Hernia Society annual meeting in New York, New York, March 28-31, 2012

21. Ward KC, Costello KP, Baalman S, Pierce RA, Deeken CR, Frisella MM, Brunt LM,

Matthews BD Effect of acellular human dermis buttress on laparoscopic hiatal hernia repair. Presented at the American Hernia Society annual meeting in New York, New York, March 28-31, 2012

22. Cavallo JA, Roma AA, Jasielec M, Ousley J, Creamer J, Baalman S, Frisella MM, Matthews BD, Deeken CR A Risk Prediction Model for Biologic Mesh Remodeling and

Collagen Distribution after Abdominal Wall Reconstruction: An Analysis of Explants by Host Characteristics and Surgical Site Classifications. Presented at the Americas Hernia Society annual meeting in Orlando, Florida, March 13-16, 2013

23. Ray S, Ward KC, Barrett CD, Pichert MD, Eliason BJ, MacEwan MR, Frisella MM, Deeken

CR, Matthews BD. Histological and biomechanical evaluation of novel electrospun scaffold

in a porcine model of ventral hernia repair. Oral presentation at 9th Annual Academic Surgical Congress, San Diego, California, Feb. 4th, 2014

24. Ray S, Ward KC, Barrett CD, Costello KP, Deeken CR, Baalman S, Frisella MM, Matthews

BD. MAUDE database audit shows inaccurate representation of mesh-related adverse events

and trends. Society of American Gastrointestinal and Endoscopic Surgeons meeting, Salt Lake City,

UT, April 4, 2014

25. Sharma K, Cavallo JA, Gangopadhyay N, Dudas J, Roma AA, Baalman S, Tenenbaum M, Matthews BD, Deeken CR, Myckatyn T. The histologic impact of chemotherapy and radiation on the remodeling of acellular dermal matrices in staged, prosthetic breast reconstruction. American Society of Plastic Surgeons annual meeting, Chicago, IL, October 12, 2014.

26. Deeken CR, Thompson, Jr. DM, Castile RM, Lake SP. Biaxial Analysis of Synthetic

Scaffolds for Hernia Repair Demonstrates Variability in Mechanical Anistropy, Non-linearity, and Hysteresis. Biomedical Engineering Society Annual Meeting, San Antonio, TX, October 24, 2014.

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Regional Conferences: 1. Lerdsirisopon S, Deeken CR, Frisella MM, Matthews BD Effect of application of helical

titanium tacks on the biomechanical properties of hernia repair materials. Missouri Chapter American College of Surgeons Annual Meeting, Kansas City, Missouri, June 12-13, 2010

POSTERS: National Conferences: 1. Costello CR, Bachman SL, Ramshaw BJ, Grant SA Surface and bulk characterization of

explanted hernia meshes. Biomedical Engineering Society Fall Meeting, Chicago, IL, Oct. 2006

2. Bachman SL, Cleveland DS, Costello, CR, Loy TS, Grant SA, Ramshaw BJ Bridging the gap: Use of porcine small intestine submucosa mesh for laparoscopic ventral hernia repair in a porcine model with varying defect sizes. Hernia Repair 2007, 10th Anniversary Hernia Congress, Hollywood, FL, Mar. 2007

3. White AK, Costello CR, Grant SA Agarose entrapped gold nanoparticles for the

crosslinking of collagen. Institute of Biological Engineering Annual Meeting, St. Louis, MO, Mar. 2007

4. Costello KP, McFarland KL, Grant DA, Costello CR, Grant SA Investigation of the

mechanical strength of explanted polypropylene hernia meshes. Institute of Biological Engineering Annual Meeting, St. Louis, MO, Mar. 2007

5. Costello CR, White AK, Jouret JE, Bachman SL, Ramshaw BJ, Grant SA Development of an acellular porcine tissue scaffold for soft tissue repair applications. Biomedical Engineering Society Fall Meeting, Los Angeles, CA, Sept. 2007

6. Costello, C.R., Bachman, S.L., Ramshaw, B.J., Grant, S.A. A novel, crosslinked bionanocomposite material for soft tissue repair applications. Biomedical Engineering Society Fall Meeting, Los Angeles, CA, Sept. 2007

7. Deeken CR, Abdo MS, Frisella MM, Matthews BD Physicomechanical Evaluation of

absorbable and nonabsorbable barrier composite meshes for laparoscopic ventral hernia repair. Society of American Gastrointestinal and Endoscopic Surgeons meeting, National Harbor, MD, April 14-17, 2010

8. Pichert MD, Cavallo JA, Frisella MM, Matthews BD, Deeken CR Collagen type I and III

distribution found in biological scaffold materials explanted from human subjects. Institute of Biological Engineering, Atlanta, GA, March 2011

9. Gray EK, Roma AA, Cavallo JA, Frisella MM, Matthews BD, Deeken CR Semi-quantitative evaluation of the remodeling characteristics of biological scaffold materials explanted from human subjects. Institute of Biological Engineering, Atlanta, GA, March 2011

10. Eliason BJ, Matthews BD, Frisella MM, Deeken CR Effect of repetitive loading on the mechanical properties of hernia repair materials. Institute of Biological Engineering, Atlanta, GA, March 2011

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11. Deeken CR, Matthews BD Comparison of contracture, adhesion, tissue ingrowth, and

histologic response characteristics of permanent and absorbable barrier meshes in a porcine model of laparoscopic ventral hernia repair. Hernia Repair 2011, American Hernia Society, San Francisco, California, March 16, 2011

12. Deeken CR, Melman L, Frisella MM, Matthews BD Matrix metalloproteinases in biologic mesh specimens explanted from human subjects. Hernia Repair 2011, American Hernia Society, San Francisco, California, March 16, 2011

13. Lerdsirisopon S, Matthews BD, Frisella MM, Deeken CR Biomechanical evaluation of

potential damage to hernia repair materials due to fixation with helical titanium tacks. Society of American Gastrointestinal and Endoscopic Surgeons meeting, San Antonio, Texas, April 1, 2011

14. Grant SA, Deeken CR, Grant DA, Bachman SL, Ramshaw BJ In vivo study of a novel

AuNP-tissue scaffold. Society for Biomaterials, Orlando, Florida, April 2011.

15. Pui CL, Tang ME, Annor AH, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect

of repetitive loading on the mechanical properties of biological scaffold materials. American Hernia Society annual meeting in New York, New York, March 28-31, 2012

16. Ward KC, Eagon JC, Baalman S, Deeken CR, Frisella MM, Varela JE, Brunt LM, Halpin V, Matthews BD The financial impact of postoperative complications from bariatric surgery performed abroad. 29th Annual Meeting of the American Society for Metabolic and Bariatric Surgery, San Diego, CA, June 2012

17. Xu AA, Eliason BJ, Buettmann EG, MacEwan MR, Frisella MM, Matthews BD, Deeken CR.

In vitro degradation characteristics of novel electrospun polycaprolactone (PCL) scaffolds for hernia repair applications. Biomedical Engineering Society Annual Meeting. Atlanta, Georgia, October 2012

18. Pichert MD, Xu AA, Eliason BJ, Buettmann EG, Frisella MM, Matthews BD, Deeken CR.

Characterization of the physiomechanical properties of patterned electrospun polycaprolactone scaffolds for hernia repair applications. Biomedical Engineering Society Annual Meeting. Atlanta, Georgia, October 2012

19. Cavallo JA, Roma AA, Jasielec M, Ousley J, Creamer J, Baalman S, Frisella MM, Matthews BD, Deeken CR A Risk Prediction Model for Synthetic Mesh Remodeling and

Collagen Distribution after Abdominal Wall Reconstruction: An Analysis of Explants by Host Characteristics and Surgical Site Classifications. Society of Gastrointestinal and Endoscopic Surgeons annual meeting, Baltimore, Maryland, April 17-20, 2013

20. Zihni AM, Cavallo JA, Thompson Jr. DM, Chowdhury NH, Frisella MM, Matthews BD,

Deeken CR. Evaluation of absorbable mesh fixation devices at various deployment angles.

16th Annual Hernia Repair of the Americas Hernia Society meeting in Las Vegas, NV, March 12-15, 2014

21. Ray S, Zihni AM, Baalman S, Frisella MM, Deeken CR, Matthews BD. Laparoscopic repair

of suprapubic ventral hernias: A retrospective comparison with other laparoscopic ventral hernia repairs. Society of American Gastrointestinal and Endoscopic Surgeons meeting, Salt Lake City, UT, April 4, 2014

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Regional Conferences: 1. Kelchen P, Costello CR, Grant SA Designing a test to determine physical changes in

explanted hernia meshes. Undergraduate Research and Creative Achievements Forum University of Missouri-Columbia, Columbia, MO, Aug. 2006

2. Jouret JE, Costello CR, Grant SA Assessing biocompatibility of porcine tissue for hernia

repair using flow cytometry. Undergraduate Research and Creative Achievements Forum University of Missouri-Columbia, Columbia, MO, Apr. 2007

3. Tait MA, Fox DB, Warnock JJ, Stoker AM, Costello CR, Whitener D, Cockrell M, Grant SA,

Cook JL. Effect of RGD-modification of synthetic scaffolds on synoviocyte seeding and matrix production for mensical tissue engineering. Summer Research Fellowship Symposium. University of Missouri-Columbia, School of Medicine, Columbia, MO, Oct. 2007

4. Barker S, Costello CR, Grant DA, Grant SA Effects of oxidative environments and

mechanical stress on in vitro stability of polypropylene hernia meshes. Life Sciences Week, University of Missouri, Columbia, MO, April 2008

5. Patel A, Costello CR, Grant SA Materials characterization of explanted PTFE hernia mesh.

Life Sciences Week, University of Missouri, Columbia, MO, April 2008

6. Liang AM, Gray EK, Deeken CR, Frisella MM, Matthews BD RNA Concentrations

measured in biological scaffold materials explanted from human subjects. Washington University 5th Annual Research Training Symposium, St. Louis, MO, October 2010

7. Pichert MD, Deeken CR, Frisella MM, Matthews BD Distribution of collagen I and III in

extracellular matrix-derived scaffold materials. Washington University Undergraduate Research Symposium, St. Louis, MO, October 2010

8. Gray EK, Deeken CR, Roma AA, Frisella MM, Matthews BD Feasibility of histologic

evaluation of biological scaffold materials explanted from human subjects. Washington University Undergraduate Research Symposium, St. Louis, MO, October 2010

9. Eliason BJ, Deeken CR, Frisella MM, Matthews BD Effects of crosslinking on the resistance of scaffold materials to enzymatic degradation. Washington University Undergraduate Research Symposium, St. Louis, MO, October 2010

10. Pichert MD, Cavallo JA, Frisella MM, Matthews BD, Deeken CR Collagen type I and III

distribution found in biological scaffold materials explanted from human subjects. Washington University Undergraduate Research Symposium, St. Louis, MO, April 2011

11. Gray EK, Roma AA, Cavallo JA, Frisella MM, Matthews BD, Deeken CR Semi-quantitative

evaluation of the remodeling characteristics of biological scaffold materials explanted from human subjects. Washington University Undergraduate Research Symposium, St. Louis, MO, April 2011

12. Eliason BJ, Matthews BD, Frisella MM, Deeken CR Effect of repetitive loading on the mechanical properties of hernia repair materials. Washington University Undergraduate Research Symposium, St. Louis, MO, April 2011

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13. Pui CL, Tang ME, Annor AH, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect

of repetitive loading on the mechanical properties of biological scaffold materials. Washington University 6th Annual Research Training Symposium, St. Louis, MO, October 2011

14. Ebersole GC, Buettmann EG, MacEwan MR, Tang ME, Frisella MM, Matthews BD, Deeken CR Development of novel electrospun absorbable polycaprolactone (PCL)

scaffolds for hernia repair applications. Washington University 6 th Annual Research Training Symposium, St. Louis, MO, October 2011

15. Annor AH, Tang ME, Pui CL, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect

of enzymatic degradation on the mechanical properties of biologic scaffold materials. Washington University 6th Annual Research Training Symposium, St. Louis, MO, October 2011

16. Xu AA, Eliason BJ, Buettmann EG, MacEwan MR, Frisella MM, Matthews BD, Deeken CR. In vitro degradation characteristics of novel electrospun polycaprolactone (PCL) scaffolds for hernia repair applications. Washington University Undergraduate Research Symposium, St. Louis, MO, April 2013

17. Pichert MD, Xu AA, Eliason BJ, Buettmann EG, Frisella MM, Matthews BD, Deeken CR.

Characterization of the physiomechanical properties of patterned electrospun polycaprolactone scaffolds for hernia repair applications. Washington University Undergraduate Research Symposium, St. Louis, MO, April 2013

18. Gluckstein J, Thompson, Jr. DM, Zihni A, Ray S, Frisella MM, Matthews BD, Deeken CR. Biaxial fatigue testing of hernia repair materials. Washington University 8th Annual Research Training Symposium, St. Louis, MO, October 2013

19. Ochieng P, Thompson, Jr. DM, Est S, Castile RM, Lake SP, Deeken CR. Novel scaffold

development via electrospinning and 3D printing. Washington University 9th Annual Research Training Symposium, St. Louis, MO, October 21, 2014

20. Chi T, Thompson, Jr. DM, Castile RM, Lake SP, Deeken CR. Biaxial analysis of synthetic

scaffolds for hernia repair in 90° and 45° orientation. Washington University 9th Annual Research Training Symposium, St. Louis, MO, October 21, 2014

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MENTORED RESEARCH:

Research Staff: Dominic M. Thompson, Jr., MA Visiting Scholars:

Sopon Lerdsirisopon, MD Surgery Residents:

Shaun Brown, DO Jaime Cavallo, MD Eric Jenkins, MD Lora Melman, MD Shuddhadeb Ray, MD Kyle Ward, DO Ahmed Zihni, MD

Medical and Doctoral Students: Principal Investigator: Chung, Koong-Nah, PhD Project Title: Short-Term Training in Health Professional Schools Grant Number: 2T35HL007815 National Heart, Lung, and Blood Institute National Institutes of Health Afua Annor Guillermo Ares Chris D. Barrett Tingying Chi Gregory Ebersole Jeffrey Gluckstein Amy Margaret

Liang Matthew MacEwan Peter Ochieng Chi Lun Pui Adrian Simien Michael Tang Wenjing Zeng

Undergraduate Students:

Michael Abdo Sarah Barker Edmond Benedetti Evan Buettmann Nabeel Chowdhury Kevin Costello Braden Eliason Erin Emerick Savannah Est

Emily Gray James Harrang Jill Jouret Phillip Kelchen Kacy McFarland Amy Patel Matthew Pichert George Rizk Amanda White Alexander Xu

FUNDING HISTORY:

Past Funding: ($1,469,737)

1. Title: Anti-Adhesion Study on Kensey Nash Corporation Surgical Meshes Role: Principal Investigator Amount: $63,423 total; $42,282 direct costs Dates: 08/25/2009 – 02/24/2011 Sponsor: Kensey Nash Corporation Goals: The major goals of this project are to evaluate the anti-adhesion properties of

surgical mesh materials using a rabbit model with abrasion of the cecum to stimulate adhesion formation.

2. Title: Histological Analysis of Explanted Hernia Mesh Materials

Role: Principal Investigator Amount: $6,723 total; $4,482 direct costs Dates: 04/19/2010-10/27/2012 Sponsor: Atrium Medical Corporation Goals: The major goals of this project are to evaluate the histological characteristics of

synthetic mesh materials explanted from human subjects. 3. Title: Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol (PEG)

Sealant in a Porcine Model Role: Principal Investigator Amount: $29,999 total; $29,999 direct costs Dates: 05/01/2010 – 04/30/2011 Sponsor: Society of American Gastrointestinal and Endoscopic Surgeons Goals: The major goals of this project are to evaluate the fixation strength of porcine

small intestine submucosa biological mesh at the hiatus using two types of biological sealants.

4. Title: Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol (PEG)

Sealant in a Porcine Model Role: Principal Investigator Amount: $13,458 (product donation value) Dates: 05/01/2010 – 04/30/2011

Sponsor: Baxter Healthcare Goals: The major goals of this project are to evaluate the fixation strength of porcine

small intestine submucosa biological mesh at the hiatus using two types of biological sealants.

5. Title: Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol (PEG)

Sealant in a Porcine Model Role: Principal Investigator Amount: $25,000 (product donation value) Dates: 05/01/2010 – 04/30/2011

Sponsor: Cook Biotech

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Goals: The major goals of this project are to evaluate the fixation strength of porcine small intestine submucosa biological mesh at the hiatus using two types of biological sealants.

6. Title: Enzymatic Degradation of Biological Tissue-Based Scaffold Materials and the

Effect on Tensile Strength Over Time Role: Principal Investigator Amount: $99,995 total; $83,329 direct costs Dates: 01/01/2011 – 12/31/2011 Sponsor: Musculoskeletal Transplant Foundation Dermal Tissue Research Grant Goals: The major goals of this project are to elucidate how variables such as tissue type

and processing conditions affect the scaffold’s ability to resist enzymatic degradation and retain its original tensile strength over a variety of exposure times.

7. Title: A Prospective Multicenter Trial to Evaluate Adhesion Characteristics and

Adhesiolysis-related Complications of Barrier-coated and Non-barrier-coated Intraperitoneal Mesh During Abdominal Re-exploration After Prior Ventral Hernia Repair

Role: Co-Investigator (PI: Cavallo) Amount: $200,000 total; $133,000 direct costs Dates: 01/01/2011-01/02/2013 Sponsor: NIH KM1 Goals: The major goals of this project are to compare the benefits, harms, and

comparative effectiveness of intraperitoneal barrier-coated and non-barrier coated VHR mesh in reducing adhesions, adhesion related complications, and adhesiolysis sequelae in actual patient subpopulations and clinical circumstances.

8. Title: Nanofiber Materials for Hernia Repair

Role: Co-Investigator (PI: Moran) Amount: $62,038 Dates: 03/2011-03/2012 Sponsor: Washington University Fund for Translation Research Goals: The major goal of this project was to develop novel, nanofabricated meshes and

materialsfor use in the surgical repair of hernia defects and other soft-tissue repair procedures.

9. Title: A Prospective Multicenter Trial to Evaluate Adhesion Characteristics and

Adhesiolysis-related Complications of Barrier-coated and Non-barrier-coated Intraperitoneal Mesh During Abdominal Re-exploration After Prior Ventral Hernia Repair

Role: Co-Investigator (PI: Matthews) Amount: $300,000 total; $200,000 direct costs Dates: 06/01/2011-05/31/2014 Sponsor: Atrium Medical Corporation Goals: The major goals of this project are to compare the benefits, harms, and

comparative effectiveness of intraperitoneal barrier-coated and non-barrier coated VHR mesh in reducing adhesions, adhesion related complications, and adhesiolysis sequelae in actual patient subpopulations and clinical circumstances.

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10. Title: Effects of Enzymatic Degradation and Repetitive Loading on the Tensile Strength of Crosslinked and Non-Crosslinked Porcine Dermis

Role: Principal Investigator Amount: $86,310 total; $57,542 direct costs Dates: 06/07/2011 – 06/06/2012 Sponsor: Covidien Investigator Sponsored Research Grant Goals: The major goals of this project are to determine the effects of enzymatic

degradation and repetitive loading on the tensile strength of three porcine dermis scaffold materials to improve surgeons’ understanding of which materials are at risk for rapid loss of strength in contaminated or high stress environments.

11. Title: Physicomechanical Evaluation of a Collagen-Based Hernia Repair Material

Role: Principal Investigator Amount: $5,298 total; $3,532 direct costs Dates: 10/15/2011-10/14/2012 Sponsor: OBI Biologics, Inc. Goals: The major goals of this project are to evaluate the physicomechanical properties

of a collagen-based hernia repair material via laser micrometry, suture retention, tear resistance, and ball burst testing.

12. Title: Effect of Implantation Angle on the Fixation Strength of Absorbable Fixation

Devices in Porcine Abdominal Wall Tissue Role: Principal Investigator Amount: $66,920 total; $44,613 direct costs Dates: 04/30/2012-03/31/2013 Sponsor: Ethicon, Inc. Goals: The major goals of this project are to evaluate the fixation strength achieved

when absorbable fixation devices are utilized to attach permanent mesh materials to the porcine abdominal wall at a variety of implantation angles.

13. Title: Characterization of Hernia Repair Materials

Role: Principal Investigator Amount: $39,339 total; $26,226 direct costs Dates: 01/25/2013-01/24/2014 Sponsor: Atrium Medical Corporation Goals: The major goals of this project are to evaluate the physiomechanical properties

of a novel hernia repair material via physical, thermal, and enzymatic characterization techniques.

14. Title: Protocol Development for Evaluation of Fortiva in a Porcine Model of Ventral

Hernia Repair Role: Principal Investigator Amount: $2,312 total; $1,541 direct costs Dates: 09/01/2013-09/30/2013 Sponsor: RTI Surgical Goals: The major goals of this project are to develop a protocol for a porcine study to

evaluate Fortiva in a functional hernia repair model.

15. Title: Impact of ADMs on Biofilms Around Breast Implants Role: Co-Investigator (PI: Myckatyn)

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Amount: $52,900 total Dates: 02/01/2013-01/31/2014 Sponsor: ASERF Goals: The major goals of this project are to evaluate biofilm formation approximately 3

to 24 months after placement of a textured tissue expander in the presence of an acellular dermal matrix

16. Title: Cyclic Loading of Hernia Mesh Prototypes

Role: Principal Investigator Amount: $223,021 total; $148,680 direct costs Dates: 12/09/2012 – 12/08/2014 Sponsor: Covidien Goals: The major goals of this project are to evaluate the mechanical and histological

properties of 5 prototypes of 2-dimensional, monofilament PET mesh via benchtop and in vivo techniques in order to determine the effect of porosity and

mesh density on tissue ingrowth, foreign body response, and mechanical properties

17. Title: Effect of Deployment Angle on the Lap Shear Strength of Absorbable Fixation

Devices in Porcine Abdominal Wall Tissue Role: Principal Investigator Amount: $77,478 total; $51,652 direct costs Dates: 11/12/2014 – 11/11/2015 Sponsor: Covidien Goals: The major goals of this project are to evaluate the fixation strength achieved

when various types of absorbable fixation devices are utilized to attach synthetic mesh to the porcine abdominal wall at implantation angles of 30, 45, 60, and 90 degrees.

18. Title: 3D Printing as a Means to Optimize Patient Outcomes

Role: Co-Investigator (PI: Woo) Amount: $85,523

Sponsor: Barnes Jewish Hospital Foundation 19. Title: Promoting Mechanical Integration at the Tissue-Biomaterial Interface in Ventral

Hernia Repair Role: Principal Investigator Amount: $30,000

Sponsor: Society of American Gastrointestinal and Endoscopic Surgeons

Submitted Proposals (Pending Review): ($1,906,250)

1. Title: Promoting Mechanical Integration at the Tissue-Biomaterial Interface in Ventral Hernia Repair

Role: Principal Investigator Amount: $1,906,250

Sponsor: NIH R01

Submitted Proposals (Not Funded): ($11,521,255) 1. Title: Randomized Controlled Trial of Mesh Reinforcement for Distal Pancreatectomy

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Role: Co-Investigator (PI: Hawkins) Amount: $2.8 million Sponsor: National Institutes of Health (NIH RO1 #CA143414-01)

2. Title: Establishment of an Explant Mesh Repository for Biomaterial and Patient Data Analysis

Role: Co-Investigator (PI: Grant) Amount: $2.9 million Sponsor: National Institutes of Health (RC2 “Grand Opportunities”)

3. Title: Comparison of the Physicomechanical Properties of Two Crosslinked Porcine Dermis Hernia

Repair Materials Role: Principal Investigator Amount: $20,000 Sponsor: Covidien Clinical Educational/Research Grant

4. Title: Characterization of the Remodeling and Integration of Biologic Hernia Repair

Materials Role: Co-Investigator Amount: $14,871 Sponsor: American Hernia Society and LifeCell 2009 Hernia Resident/Fellow Grant

5. Title: Effects of Radiation on the Remodeling of Biological Tissue-Based Scaffold

Materials Used for Breast Reconstruction: A Human Explant Study Role: Principal Investigator, 15% effort Amount: $86,852 Sponsor: Musculoskeletal Transplant Foundation

6. Title: Equipment to Support Biomaterial and Patient Data Analysis of Mesh Materials Explanted from Human Subjects

Role: Principal Investigator, 10% effort Amount: $305,618 Sponsor: Missouri Life Sciences Research Board

7. Title: Equipment to Support Characterization of Explanted Surgical Mesh Materials

Role: Principal Investigator, 2.0% effort Amount: $24,997 Sponsor: Barnes-Jewish Hospital Foundation & WU Institute for Clinical and Translational Sciences

8. Title: Characterization of the Physicomechanical Properties of Biologic Tissue-Based Hernia Repair Materials

Role: Principal Investigator, 6.0% effort Amount: $217,718 Sponsor: Synovis Life Technologies

9. Title: Characterization of Explanted Surgical Mesh Materials: A Histological Assessment

Role: Principal Investigator, 25% effort Amount: $180,000 ($60,000 per year, 3 years)

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Sponsor: Edward Mallinckrodt, Jr. Foundation Grant Program

10. Title: Comprehensive Histological Analysis of Explanted Hernia Repair Materials Role: Co-Investigator Amount: $24,956 Sponsor: Hernia Resident/Fellow Research Grant

11. Title: Utilizing GFP Producing Swine to Investigate Bio-nanocomposite Biologic Prosthetics

Role: Co-Investigator, 8.0% effort each year Amount: $75,948 (subcontract budget only) Sponsor: NSF

12. Title: Capital Equipment Donation Request

Role: Principal Investigator Amount: Incubator, biosafety cabinet, microscope with camera, plate reader Sponsor: Pfizer

13. Title: Fixation Strength of Fibrin Sealant Utilized to Secure Biological Mesh Products at the Hiatus in a Porcine Model

Role: Principal Investigator, 8.0% effort Amount: $124,605 Sponsor: Baxter Healthcare

14. Title: Evaluation of a Non-Crosslinked Porcine Dermis Product in a Porcine Model of Ventral Hernia Repair

Role: Principal Investigator, 10.0% effort in Year #1 and 6.0% effort in Year #2 Amount: $306,615 Sponsor: Davol, Inc.

15. Title: Anti-Adhesion Characteristics of Two Novel Biologic-Synthetic Composite

Meshes Compared to Existing Absorbable Barrier and Bare Polypropylene Meshes in a Rabbit Model

Role: Principal Investigator, 15.0% effort Amount: $127,987 Sponsor: Kensey Nash Corporation

16. Title: Investigation on the Effect of Biologic Scaffold Properties on Cellular Migration Role: Co-Investigator, 8.0% effort (PI:Grant) Amount: $53,259 (subcontract budget only) Sponsor: NIH R21

17. Title: Effect of Enzymatic Degradation on the Tensile Strength of Human and Porcine Dermis Materials

Role: Principal Investigator, 8.0% effort Amount: $59,909 Sponsor: Musculoskeletal Transplant Foundation (R&D)

18. Title: Effect of Repetitive Loading on the Tensile Strength of Human and Porcine Dermis Materials

Role: Principal Investigator, 8.0% effort

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Amount: $69,149 Sponsor: Musculoskeletal Transplant Foundation (R&D)

19. Title: Novel Nanofiber Scaffolds for Ventral Hernia Repair: Pre-Clinical Comparison of Gore® Bio-A®, TIGR® Matrix, and Nanofiber Scaffolds in a Porcine Model

Role: Principal Investigator,10.0% effort Amount: $29,991 Sponsor: SAGES

20. Title: Tissue Organization Capabilities and Biomechanical Properties of Novel

Electrospun Nanofiber Scaffolds for Hernia Repair Applications: A Multi-Scale Investigation Spanning In

Vitro, Small Animal, and Large Animal Models Role: Principal Investigator, 10.0% effort Amount: $55,250 (Year #1), $59,955 (Year #2), $58,650 (Year #3) Sponsor: Mallinckrodt Foundation (internal competition)

21. Title: Tissue Organization Capabilities and Biomechanical Properties of Novel Electrospun Nanofiber

Scaffolds for Hernia Repair Applications Role: Principal Investigator, 5.0% effort Amount: $39,162 Sponsor: Washington University Center for Musculoskeletal Research Pilot & Feasibility

Studies

22. Title: Tissue Organization Capabilities and Biomechanical Properties of Novel Electrospun Nanofiber Scaffolds for Hernia Repair Applications: A Multi-Scale Investigation Spanning In Vitro, Small Animal, and Large Animal Models

Role: Principal Investigator, 15.0% effort Amount: $57,777 (Year #1), $59,986 (Year #2), $59,761 (Year #3) Sponsor: Mallinckrodt Foundation (internal competition)

23. Title: Investigation on the Effect of Biologic Scaffold Properties on Cellular Migration Role: Co-Investigator, 8.0% effort (PI: Grant) Amount: $53,418 (subcontract budget only) Sponsor: NIH R21

24. Title: Physicomechanical Evaluation of Cousin Biotech Meshes Role: Principal Investigator, 5.0% effort Amount: $8,872 Sponsor: Cousin Biotech

25. Title: Remodeling Characteristics and Collagen Distribution in Biological Scaffold Materials Explanted from Human Subjects after Abdominal Soft Tissue Reconstruction

Role: Principal Investigator, 10% effort Amount: $118,082 Sponsor: Musculoskeletal Transplant Foundation

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26. Title: Comparison of the Remodeling Characteristics and Biomechanical Properties of Two Biologic Hernia Repair Materials in a Porcine Model of Ventral Hernia

Repair Role: Principal Investigator, 5% effort Amount: $354,875 total Sponsor: Musculoskeletal Transplant Foundation

27. Title: Evaluation of a Mesh Deployment Device in a Porcine Model of Ventral Hernia

Repair Role: Principal Investigator, 10% effort Amount: $166,031 Sponsor: Atrium Medical Corporation

28. Title: Comparison of the Remodeling Characteristics and Biomechanical Properties of Two Synthetic

Absorbable Hernia Repair Materials in a Porcine Model of Ventral Hernia Repair Role: Principal Investigator, 5% effort Amount: $284,928 Sponsor: W.L. Gore & Associates, Inc.

29. Title: Comparison of the Remodeling Characteristics and Biomechanical Properties of a Novel Synthetic Absorbable Hernia Repair Materials in a Porcine Model of Ventral Hernia Repair

Role: Principal Investigator, 5% effort Amount: $234,786 Sponsor: Novus Scientific

30. Title: Development of Novel Electrospun Polycaprolactone Scaffolds for Hernia Repair

Role: Principal Investigator, 5% effort Amount: $50,000 Sponsor: BJHF-ICTS

31. Title: Comparison of Gore® Bio-A® to Novel Absorbable Electrospun Scaffolds in a Porcine Model of Ventral Hernia Repair Role: Principal Investigator, 5% effort Amount: $29,843 Sponsor: SAGES

32. Title: Remodeling Characteristics and Biomechanical Properties of a Novel Biologic Hernia Repair

Material in a Porcine Model of Ventral Hernia Repair Role: Principal Investigator, 10% effort Amount: $461,632 Sponsor: LifeNet Health

33. Title: Novel Electrospun Scaffolds for Soft Tissue Repair Applications Role: Principal Investigator Amount: $164,254 Sponsor: The Foundation for Barnes-Jewish Hospital

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34. Title: The Mechanics and Physics of Surgical Adhesions Role: Principal Investigator Amount: $49,855 Sponsor: Barnes Jewish Hospital Foundation and the Institute for Clinical and Translational Sciences

35. Title: Remodeling Characteristics and Biomechanics of a Novel Hernia Repair Material in a Porcine Model of Ventral Hernia Repair Role: Principal Investigator Amount: $69,815 Sponsor: Atrium Medical Corporation

36. Title: Characterization of the Mechanical Properties of Synthetic Mesh via Biaxial Testing

Role: Principal Investigator Amount: $42,150 Sponsor: Covidien

37. Title: Biaxial Testing to Assess the Biomechanics of Fresh Human Abdominal Wall Tissue Role: Principal Investigator Amount: $86,550 Sponsor: Covidien

38. Title: Characterization of Mesh Explanted from Human Subjects Role: Principal Investigator Amount: $268,845 Sponsor: Covidien

39. Title: Development of Nanofabricated Patch for Treatment of Rectovaginal Fistulae Role: Co-Investigator (PI: Guttierez) Amount: $49,300 Sponsor: Barnes Jewish Hospital Foundation and the Institute for Clinical and Translational Sciences

40. Title: Comparison of Two Non-Crosslinked Porcine Dermis Products and an Absorbable Synthetic

Hernia Repair Material in a Porcine Model of Ventral Hernia Repair Role: Principal Investigator Amount: $650,903 Sponsor: RTI

41. Title: Development of Nanofabricated Patch for Treatment of Rectovaginal Fistulae Role: Co-PI with Guttierez Amount: $24,150 Sponsor: University Research Strategic Alliance

42. Title: Understanding the Mechanism of Adhesion Formation Role: Co-PI with Genin

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Amount: $24,819 Sponsor: University Research Strategic Alliance

43. Title: Comparison of Two Non-Crosslinked Porcine Dermis Products in a Porcine Model of Ventral

Hernia Repair Role: Principal Investigator Amount: $157,986 Sponsor: Davol

44. Title: Evaluation of the Durability of Zenapro Mesh Compared to Other Barrier Meshes

in a Rabbit Model Role: Principal Investigator Amount: $240,462

Sponsor: Cook Biotech 45. Title: Targeted Biomimicry to Promote Muscle Integration at the Biomaterial-Tissue

Interface in Ventral Hernia Repair Role: Co-Investigator (PI: Meyer) Amount: $40,000

Sponsor: Center for Regenerative Medicine 46. Title: Inexpensive, Custom, 3D-Printed Prosthetics for Transradial Amputees

Role: Principal Investigator Amount: $76,683

Sponsor: Barnes Jewish Hospital Foundation

HONORS & AWARDS:

2005 Tau Beta Pi Honor Society 2005-2006 National Science Foundation Grades K-12 Teaching Fellowship 2006-2008 National Science Foundation Graduate Research Fellowship 2007 Outstanding Graduate Student Award, Department of Biological Engineering

GRANT REVIEW EXPERIENCE: 2011-2012 Musculoskeletal Transplant Foundation

EDITORIAL EXPERIENCE: 2009-present Journal of the American College of Surgeons, reviewer 2010-present Hernia, reviewer 2011-present Journal of Materials Science: Materials in Medicine, reviewer 2011-present Journal of Biomedical Materials Research – Part A, reviewer 2011-present Surgery, reviewer 2014-present Journal of Biomedical Materials Research – Part B, reviewer 2014-present Biomaterials, reviewer 2014-present Journal of the Mechanical Behavior of Biomedical Materials, reviewer

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COMMUNITY SERVICE:

2001-2002 Tutored college students in Trigonometry, College Algebra, and AutoCAD 2005-2006 Taught 9th Grade Science and 8th Grade Industrial Technology 2005-2006 Directed an after school LEGO Robotics Club for 8th and 9th Grade

students 2005-2006 Volunteer, Science of Life Summer Camp 2005-2006 Volunteer, College of Engineering Summer Camp 2006 Volunteer, Saturday Science Program 2007-2008 Vice President, Biomedical Engineering Society

2011 Volunteer, Surgical mission trip to the Dominican Republic