CURRICULUM VITAE/BIBLIOGRAPHY Hirohito Kita, M · 2017-07-04 · 2008 Reviewer for Arthritis Research Campaign (UK) 2012-2015 NIH Study Section Ad Hoc Member (HAI, Hypersensitivity,

CURRICULUM VITAE/BIBLIOGRAPHY Hirohito Kita, M.D.

1. PERSONAL INFORMATION Date of Birth: February 21, 1958 Place of Birth: Mie, Japan Citizenship: Japanese, holds U.S. permanent residency

2. PRESENT ACADEMIC RANK AND POSITION

Professor of Medicine, Mayo Clinic College of Medicine, Rochester, MN Professor of Immunology, Mayo Clinic College of Medicine, Rochester, MN Walter and Leonore Annenberg Professor of Pulmonary Medicine, Mayo Clinic, Rochester, MN Consultant, Department of Internal Medicine (Division of Allergic Diseases), Department of Immunology, Department of Pediatric and Adolescent Medicine, and Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN

3. EDUCATION

1977-1983 Mie University School of Medicine, Mie, Japan (cum laude) M.D. (1983) 1983-1985 Residency in Pediatrics, Shizuoka Children's Hospital, Shizuoka, Japan 1985-1986 Residency in Pediatric Allergy, Department of Pediatrics and Allergy, Mie National Hospital, Mie, Japan 1986-1987 Postdoctoral Fellow, Department of Pediatrics and Allergy, Mie National Hospital, Mie, Japan 1987-1988 Fellow in Pediatrics, Mie University School of Medicine, Mie, Japan 1988-1991 Postdoctoral Research Fellow in the Departments of Immunology and Internal Medicine, Mayo Clinic, Rochester, MN

4. BOARD CERTIFICATION None

5. MEDICAL LICENSURE Japan

6. HONORS/AWARDS/PATENTS

1989 Travel Award, American Academy of Allergy, Asthma, and Immunology 2014 Dean’s Recognition Award, Mayo Graduate School. 2015 William T. Shearer and Lynn Des Prez Lectureship, American Academy of Allergy, Asthma, and Immunology

7. MILITARY SERVICE None

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8. PREVIOUS PROFESSIONAL POSITIONS AND APPOINTMENTS 1983-1985 Residency in Pediatrics, Shizuoka Children's Hospital, Shizuoka, Japan 1985-1986 Residency in Pediatric Allergy, Department of Pediatrics and Allergy, Mie National Hospital, Mie, Japan 1986-1987 Postdoctoral Fellow, Department of Pediatrics and Allergy, Mie National Hospital, Mie, Japan 1987-1988 Fellow in Pediatrics, Mie University School of Medicine, Mie, Japan 1988-1991 Postdoctoral Research Fellow in the Departments of Immunology and Internal Medicine, Mayo Clinic, Rochester, MN 1991-1992 Instructor, Department of Pediatrics, Mie University School of Medicine, Mie, Japan 1992-1994 Research Associate in the Department of Immunology, Mayo Clinic, Rochester, MN 1993-2000 Assistant Professor in Immunology, Mayo Clinic College of Medicine, Rochester, MN 1994-1998 Associate Consultant in the Department of Immunology, Mayo Clinic, Rochester, MN 1998-2002 Senior Associate Consultant in the Department of Internal Medicine (Division of Allergy and Outpatient Infectious Diseases), the Department of Pediatric and Adolescent Medicine, and the Department of Immunology, Mayo Clinic, Rochester, MN 1999-2003 Associate Professor in Medicine, Mayo Clinic College of Medicine, Rochester, MN 2000-2010 Associate Professor in Immunology, Mayo Clinic College of Medicine, Rochester, MN 2002-present Consultant in the Department of Medicine (Division of Allergic Diseases), the Department of Immunology, the Department of Pediatric and Adolescent Medicine, and the Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN 2003-present Professor in Medicine, Mayo Clinic College of Medicine, Rochester, MN 2011-present Professor in Immunology, Mayo Clinic College of Medicine, Rochester, MN 2011-present Walter and Leonore Annenberg Professor of Pulmonary Medicine, Mayo Clinic, Rochester, MN

9. PROFESSIONAL MEMBERSHIPS AND SOCIETIES (Extramural only) National Institutes of Health Study Section Members

1995 NIH Special Review Committee Member (NIAID, National Institute of Allergy and infectious Disease) 1998, 1999 NIH Study Section Ad Hoc Member (IMS, Immunological Sciences Study Section) 1999 NIH Special Emphasis Panel Member (NIAID, National Instituted of Allergy and Infectious Diseases) 1999-2003 NIH Study Section Regular Member (IMS, Immunological Sciences Study Section) 2001, 2004 NIH Special Emphasis Panel Member (NHLBI, National Heart Lung and Blood Institute) 2003 NIH Special Emphasis Panel Member (NIAID, National Instituted of Allergy and Infectious Diseases)

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2004 NIH Special Emphasis Panel Member (Immunology IRG) 2005 NIH Study Section Ad Hoc Member (CRFS, Clinical Research and Field Studies) 2005 NIH Special Emphasis Panel Member (Immunology IRG) 2005 NIH Special Emphasis Panel Member (LCMI Member Conflict, ZRG1 RES-C) 2005 NIH Special Emphasis Panel Member (NIDCR, ZDE1SS32) 2005-2006 NIH Study Section Regular Member (CRFS, Clinical Research and Field Studies) 2006 NIH Study Section Ad Hoc Member (HAI, Hypersensitivity, Autoimmune and Immune-mediated Diseases Study Section) 2007-2011 NIH Study Section Regular Member (HAI, Hypersensitivity, Autoimmune and Immune-mediated Diseases Study Section) 2012, 2013, 2014, 2014, 2015, 2016 NIH Study Section Ad Hoc Member (HAI, Hypersensitivity, Autoimmune and Immune-mediated Diseases Study Section) 2012 NIH Special Emphasis Panel Member (NIAID, National Instituted of Allergy and Infectious Diseases) 2013 NIH Special Emphasis Panel Member (NIDCD, National Instituted of Deafness and Other Communication Disorders, ZDC1 SRB-R(34)) 2013 NIH Special Emphasis Panel Member (NHLBI, National Heart, Lung, and Blood Institute, NHLBI Workgroup, HLBP I) 2014 National Institue on Minority Health and Health Disparities Special Empahsis Panel (National Institue on Minority Health and Health Disparities. ZMD1MLS(L2)). 2014 NIH Special Emphasis Panel Member (NIAID, National Instituted of Allergy and Infectious Diseases, NIAID Investigator Intitiated Program Project Applications, ZAI1 BDP-I (M1)) 2014 NIH Special Emphasis Panel Member (NIAID, National Instituted of Allergy and Infectious Diseases, ZAI1 ZL-1) 2015 National Institute on Minority Health and Health Disparities Special Empahsis Panel (National Institute on Minority Health and Health Disparities. ZMD1MLS(L2)). 2015 NIH Special Emphasis Panel Member (Member Conflicts: Asthma and Host Defense. ZRG1 CVRS-N(02)) 2015 NIH Special Emphasis Panel Member (Member Conflicts: immune response, asthma and inflammation. ZRG1 CVRS-N(03)) 2015 NIH Special Emphasis Panel Member (NHLBI, National Heart, Lung, and Blood Institute, ZHL PPG-S (Fi1)

Memberships in Professional Societies American Academy of Asthma Allergy and Immunology American Association of Immunologist American Thoracic Society American Association for the Advancement of Science American Medical Association Society for Leukocyte Biology Japanese Society of Allergology Japanese Society of Pediatrics Japanese Society for Child Health Committee Responsibilities in Society

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1999-2004 Research Advisory Council Member, American Academy of Allergy Asthma and Immunology 2003-2008 Seminars Subcommittee Member, American Academy of Allergy Asthma and Immunology 2009-2012 Plenary Subcommittee Member, American Academy of Allergy Asthma and Immunology 2009-2010 NHLBI/NIAID Asthma Outcomes Workshop committee member 2009-present Fungal Diseases of Lower Airway Task Force member, American Academy of Asthma and Immunology 2011-present Board member, International Eosinophil Society (IES) 2013-present Secretary/Treasurer, International Eosinophil Society (IES) Memberships in Editorial Board 1995-2001 Associate Editor, Journal of Immunology 1996-2001 Editorial Board Member, Journal of Allergy and Clinical Immunology 2012-present Editorial Board Member, Clinical Immunology 2012-present Editorial Board Member, Allergology International 2017-present Editorial Board Member, Journal of Allergy and Clinical Immunology 2017-present Review Editor, Frontiers in Immunology Scientific Reviewer for Grants

1995, 1999 NIH Special Emphasis Panel Member (NIAID, National Institute of Allergy and Infectious Disease) 1996-present Reviewer for the Merit Review grant (Department of Veterans Affairs)

1997 Reviewer for the National Asthma Campaign Project grant (London, U.K.) 1997 Reviewer for the British Columbia Lung Association grant (Canada) 1998-present Reviewer for the Wellcome Trust fund (London, U.K.) 1998, 1999 NIH Study Section Ad Hoc Member (IMS, Immunological Sciences Study Section) 1999-2003 NIH Study Section Regular Member (IMS, Immunological Sciences Study Section)

1999-present Reviewer for the Netherlands Organization for Scientific Research (Netherlands) 1999-2004 Grant Review Committee Member, American Academy of Allergy Asthma and Clinical Immunology 2001, 2004 NIH Special Emphasis Panel Member (NHLBI, National Heart Lung and Blood Institute) 2003 NIH Special Emphasis Panel Member (NIAID, National Instituted of Allergy and Infectious Diseases) 2004 NIH Special Emphasis Panel Member (Immunology IRG) 2005, 2008 Reviewer for the National Medical Research Council (Singapore) 2005 NIH Study Section Ad Hoc Member (CRFS, Clinical Research and Field Studies) 2005 NIH Special Emphasis Panel Member (Immunology IRG) 2005 NIH Special Emphasis Panel Member (LCMI Member Conflict, ZRG1 RES-C) 2005 Reviewer for the Ireland Health Research Board (Ireland) 2005 NIH Special Emphasis Panel Member (NIDCR, ZDE1SS32)

2005-2006 NIH Study Section Regular Member (CRFS, Clinical Research and Field Studies)

2006 NIH Study Section Ad Hoc Member (HAI, Hypersensitivity, Autoimmune and Immune-mediated Diseases Study Section)

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2007-2011 NIH Study Section Regular Member (HAI, Hypersensitivity, Autoimmune and Immune-mediated Diseases Study Section)

2008 Reviewer for Arthritis Research Campaign (UK) 2012-2015 NIH Study Section Ad Hoc Member (HAI, Hypersensitivity, Autoimmune and Immune-mediated Diseases Study Section) 2012, 2013. 2016 NIH Special Emphasis Panel Member (NIAID, National Institute of Allergy and Infectious Diseases) 2012, 2013 NIH Special Emphasis Panel Member (NIDCD, National Institue of Deafness and Other Communication Disorders) 2013 NIH Special Emphasis Panel Member (NHLBI, National Institute of Lung, Heart and Blood Institute) 2016, 2017 NIH Special Emphasis Panel Member (Center for Scientific Review, ZRG1 IMM-S90)

Scientific Reviewer for Medical Journals Allergy American Journal of Physiology American Journal of Respiratory and Critical Care Medicine American Journal of Respiratory Cell and Molecular Biology Annals of Allergy, Asthma and Immunology Allergology International Biochimica Et Biophysica Acta Blood Clinical and Experimental Allergy Clinical and Experimental Immunology Clinical Immunology Current Immunology Reviews Current Pharmaceutical Biotechnology European Respiratory Journal Experimental Cell Research Frontiers in Immunology Gastroenterology Immunology International Archives of Allergy and Immunology International Forum of Allergy and Rhinology International Immunopharmacology Journal of Laboratory and Clinical Medicine Journal of Leukocyte Biology Journal of Immunology Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology – In Practice Journal of Clinical Investigation Journal of Applied Physiology Journal of Immunological Methods Lancet Respiratory Medicine Lung Mucosal Immunology New England Journal of Medicine Neuroimmunomodulation Mayo Clinic Proceedings

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Pediatric Allergy and Immunology Proceedings of the National Academy of Science Science Immunology Thorax Vaccine

10. EDUCATIONAL ACTIVITIES

A. Curriculum/Course Development 1. Graduate Program Director for Immunology Track 2003-present Mayo Graduate School 2. Director, NIH Training Grant T32 AI07047 “Training Grant in Allergic Diseases” 2000-present Mayo Graduate School of Medicine

3. Course Director, “Current Topics in Clinical and Translational Immunology, IMM8867” 1993-present Two sessions a year Mayo Medical School, Mayo Graduate School, Mayo Graduate School of Medicine This is a journal club regarding the immunological mechanisms of diseases and hypersensitivity responses.

4. Course Coordinator, “Immunology Tutorial, Cell Activation Tutorial, IMM8879” 2002 winter quarter Mayo Graduate School I directed the 11-session tutorial on cell signaling mechanisms of immune cells for

immunology graduate students and post docs.

5. Course Coordinator, “Tutorial in Innate Immunity and Inflammation, IMM8882” 2007 winter quarter 2009 winter quarter 2011 winter quarter 2012 winter quarter 2013 winter quarter 2014 winter quarter Mayo Graduate School

I directed the 11-session tutorial on innate immunity and mechanisms of inflammation for immunology graduate students and post docs.

B. Teaching Activities

Courses/Lectures 1. Faculty, "Basic Graduate Immunology, Core6200" 1999-present, Dr. Dave McKean/Dr. Larry Pease/Dr. Karen Hedin course director Mayo Medical and Graduate Schools Have given lectures on cytokines and diseases and hypersensitivity responses.

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2. Faculty, "Immunology Tutorial, IMM 8880, IMM 8879 and IMM 8882" 1999-present, Dr. Larry Pease/Dr. Hirohito Kita/Dr. Paul Leibson course director Mayo Graduate School Have given lectures on host defense.

Grand Rounds 1. Medical Grand Rounds, Mayo Clinic Rochester, July 14, 1999

Lecture title; “Treatment of asthma patients with inhaled lidocaine” 2. Medical Grand Rounds, Mayo Clinic Scottsdale, April 20, 2000

Lecture title; “Chronic rhinosinusitis – the war of our immune system against the fungi” 3. Medical Grand Rounds, Mayo Clinic Rochester, July 11, 2002 Lecture title; “Asthma and chronic sinusitis: Is it a hypersensitivity response to common aeroallergens?” CME Lectures/Teaching Conferences 1. Current Topic in Hypersensitivity Reaction 2001-present Have summarized current scientific literatures, 3 lectures/year. 2. Allergy Case Conference 1999-present Have given lectures on translational research in the field of allergic diseases, 2 lectures/year.

C. Mentor

Mayo Graduate School of Medicine I have mentored research programs of the following research and clinical fellows in the Department of Medicine and the Department of Immunology. The current status of mentees is

described in the parenthesis.

Yoshio Okubo M.D. 1990-1991 Modulation of eosinophil degranulation by pharmacologic agents. (Currently an associate professor) Neil Wallen M.D. 1990 Inhibition of eosinophil survival by steroids. (Currently clinical practice) Tsukasa Ohnishi M.D. 1990-1992 Cytokines in late-phase asthmatic reactions. (Currently an assistant professor) Mikako Ide M.D. 1990-1992 Morphology of hypodense eosinophils.

Effects of NH4Cl on functions of eosinophils. (Currently an assistant professor)

Ko-Ron Chen M.D. 1992-1993 Cytotoxicity of eosinophils against endothelial

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cells. Mechanism of eosinophilic microvasculitis (Currently an assistant professor) John Hagan M.D. 1993-1995 Cytokines in Mazzoti reaction. Modulation of eosinophil survival. Mechanism of eosinophil cell death. (Currently a consultant in Mayo Clinic) Shiro Horie M.D. 1992-1994 Modulation of eosinophil degranulation by pharmacologic agents. Activation of eosinophils by cytokines. Role of adhesion molecules on function of eosinophils. (Currently clinical practice) Laura Martin Ph.D. 1993-1994 Production of IL-5 from IL-2-stimulated mononuclear cells. (Currently have a research position in industry) Masayuki Kaneko Ph.D. 1993-1995 IgE-dependent eosinophil degranulation.

Role of IgG antibody for the pathophysiology of bronchial asthma. (Currently a director of pharmacological research division in industry)

Masahiko Kato, M.D. 1993-1995 Intracellular mechanism of eosinophil activation. (Currently an associate professor) Hirokazu Nakajima M.D. 1993-1995 Specificity of EG2 antibody. Production of cytokines by eosinophils stimulated by Immunoglobulin. (Currently an associate professor) Shinji Okada, M.D. 1994-1996 Effect of lidocaine on eosinophil function. Mechanism of eosinophil transmigration. (Currently an assistant professor) Joel Klein M.D. 1994-1995 Anti-FcεRI antibody in serum of patient with autoimmune diseases. (Currently clinical practice) Aaron Levy, M.D. 1994-1996 Eosinophilic GI diseases. Analysis of eosinophil granule proteins in stool samples. Eosinophilia induced by Shiitake mushroom. (Currently clinical practice)) Jintack Kim, M.D. 1995-1997 Eosinophil activation by CD9 molecules. Mechanisms of eosinophil apoptosis. (Currently an associate professor) Yoichi Motegi, M.D. 1995-1998 Role of secretory component for eosinophil

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activation. Eosinophil signal transduction. (Currently an assistant professor)

Gerald Volcheck, M.D. 1996-1998 Effects of 2 a dre noce ptor a gonis ts on e os inophil effector function and cell death. (Currently a consultant and an assistant professor in Mayo Clinic) Hitoshi Kobayashi, M.D. 1997-1998 Production of neurotropic factors by eosinophils. (Currently an associate professor) Kiyoshi Yamazaki, M.D. 1997-2000 Mechanisms of eosinophilic liver diseases. (Currently clinical practice) Masaki Hiraguri, M.D. 1997-1999 Signal transduction mechanism of eosinophil activation. (Current status unknown) Toshio Shimizu, M.D. 1997-2000 Mechanisms of eosinophil epithelial cell interaction. (Currently clinical practice) Koji Iijima, Ph.D. 1998-2005 Effects of ICAM-1 on leukocyte activation. Mouse model of allergic airway inflammation. (Currently a research technologist in Mayo Clinic) Masato Muraki, M.D. 1998-2000 Pharmacologic modulation of eosinophil Differentiation. (Currently an associate professor)

Mickey Valyasevi, M.D. 1998-2000 Effects of eosinophil granule proteins on bronchial responses to methacholine in mice. (Currently clinical practice) Takayuki Matsuura M.D. 1999-2001 Effects of glucocorticoids on differentiation of eosinophils. (Currently an assistant professor) Seung-Heon Shin M.D. 1999-2001 Etiology and pathophysiologic mechanisms of chronic rhinosinusitis. (Currently an associate professor) Pramod Kelkar, M.D. 2000-2001 Roles 2 a dre ne rgic re ce ptor in IL-5-induced activation of eosinophils. (Currently clinical practice) Takao Kobayashi, Ph.D. 2000-2009 Role of eosinophils in allergic inflammation in mice. Satoshi Miike, M.D. 2000-2002 Role of proteases and protease-activated receptor

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in allergic inflammation. (Currently an assistant professor) Yoshinari Inoue, M.D. 2001-2003 Effects of fungal products on immune system and Inflammation. (Currently an assistant professor) Ellen Dutta, M.D. 2001-2002 Effects of local anesthetics on neutrophil function. (Currently clinical practice) Kerry Drain, M.D. 2001-2002 Cytokine production by human eosinophils. (Currently clinical practice) Kristi Monson, M.D. 2002 Effects of glucocorticoids and beta2 agonists on eosinophil survival. (Currently clinical practice) Manuel Moro, D.V.M. 2002 Immunomodulation of asthma during pregnancy. (Currently an assistant professor) Thanai Pongdee, M.D. 2001-2002 Effects of oriental medicine on eosinophil survival (Currently an assistant professor)

Chang-K Kim, M.D. 2002-2004 Detection of airway inflammation using sputum. (Currently an assistant professor) Akihiko Terada, M.D. 2002-2004 Regulation of eosinophil integrins and innate immunity. (Currently clinical practice) Thomas White, Ph.D. 2002-2005 Effects of eosinophil granules on smooth muscle (Currently a research fellow in Mayo Clinic) Kiyoshi Yamazaki, M.D. 2002-2005 Mechanisms of non-IgE mediated allergic Responses (Currently clinical practice) Arveen Thethi, M.D. 2003-2004 Role of airborne Alternaria on airway inflammation in patients with sinusitis (Currently clinical practice) Laura Davis, M.D. 2003-2004 Gene expression by CD4-positive T cells in chronic sinusitis (Currently clinical practice)

Arvind Madaan, M.D. 2003-2004 Pharmacological modulation of eosinophil functions (Currently clinical practice) Yoshinori Matsuwaki, M.D. 2004-2005 Molecular mechanisms of fungus-induced eosinophil activation

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(Currently associate professor) Damir Matesic, M.D. 2005-2006 Alternaria-specific IgG4 antibody in patients with chronic rhinosinusitis (Currently clinical practice) Theresa A. Bingemann, M.D. 2005-2006 Role of cockroach antigen in activation of

Eosinophils (Currently clinical practice)

Whitney E. Molis, M.D. 2005-2006 Role of natural killer cells in asthma (Currently clinical practice) Kota Wada, M.D. 2005-2007 Immunological mechanisms of chronic sinusitis (Currently clinical practice) Myeong Heon Shin, Ph.D. 2006 Role of environmental proteases in eosinophil activation (Currently assistant professor) Martha Karakelides, M.D. 2006 Expression of protease-activated receptor during airway inflammation (Currently private practice) Seung-Heon Shin, M.D. 2006-2007 Role of airway epithelial cells in T cell differentiation (Currently associate professor) Takehito Kobayashi, M.D. 2007-2009 Innate immune responses of human eosinophils (Currently private practice) Hideaki Kozaki, M.D. 2007-2009 Immunological mechanisms of chronic rhinosinusitis Shoban Dave, M.D. 2007 Dendritic cell response to mite allergens (Currently private practice) William B. Cherry, M.D. 2007 Eosinophil response to IL-33 (Currently private practice) Matthew A. Rank, M.D. 2007 Effects of IL-33 on dendritic cells and T cell differentiation (Currently Mayo Clinic faculty member) Brad J. McClimon, M.D. 2008 Allergy oral immunotherapy assisted by a novel dendritic cell activating agents (Currently private practice) Martha Karakelides, M.D. 2008-2010 Role of allergen proteases in development of allergic diseases

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(Currently private practice) Amitha Harish, M.D. 2009 Effect of IL-33 family cytokines on human peripheral blood lymphocytes (Currently clinical practice) Megan Mason 2010 Helper cell functions in innate Th2 cells in the lungs (Currently a postdoc at Mayo Clinic) Stephanie Fox, M.D. 2010-2011 Role of innate Th2 cells in asthma (Currently private practice) Maria Schwartz, Ph.D. 2009-2010 Chronic asthma model in mice (Currently assistant professor) Kunahl Shah, M.D. 2009-2010 IL-33 immune responses in patients with asthma (Currently private practice) Satoshi Seno, M.D. 2009-2011 Regulatory mechanisms of IL-33 release by airway epithelial cells (Currently private practice) Tomoyuki Soma, M.D. 2010-2011 Role of ATP signaling pathways in eosinophil response to microbes (Currently private practice) Kenichiro Hara, M.D. 2010-2012 Roles of staphylococcus aureus in Th2- and Th17-type immune responses in bronchial asthma (Currently private practice) Sujan Patel, M.D. 2011 Identification markers of novel innate lymphoid cells in Humans (Currently private practice) Li Drake, M.D., Ph.D. 2011-present Generation and analysis of inducible and lung- specific IL-33 transgenic mice. The effect of lung innate helper cells on the functions of B lymphocytes (Currently Clinical Allergy Fellow) Srividya Sridhara, M.D. 2011-2012 Immunological mechanisms of eosinophilic esophagitis (Currently private practice) Ichiro Tojimo, M.D. 2011-2012 Mechanisms of airway epithelial cell activation in

response to allergen proteases (Currently Assistant Professor) Jenna Podjasek, M.D. 2012-2013 Development and validation of a test for determining T-helper (Th1) vs. Th2 immune profile

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(Currently private practice) Yong-Han Sun, M.D. 2012-2013 Mechanisms of IL-1alpha production and release by airway epithelial cells (Currently private practice) Shefali Samant, M.D. 2012-2013 Local immunologic measurements in chronic

rhinosinusitis exacerbations: A prospective study with normal control comparisons

(Currently private practice) Nobuhito Sasaki, M.D. 2013-2014 Association of vascular endothelial cell and IL-33 (Currently assistant professor) Ravi Anapama, M.D. 2013-2014 Role of exogenous allergen exposure in eosinophilic

esophagitis (Currently private practice) Regan Pyle, M.D. 2013-2014 Assessment of longitudinal humoral response to

pneumococcal vaccine. Asthmatic children with SHS (Currently private practice) Masaru Uchida, M.D. 2013-2015 Investigate the role of IL-33 in chronic airway

inflammation and to elucidate the immunological mechanisms involved

(Currently assistant professor) Sara May, M.D. 2013-2015 Increased risk of morbidity of second-hand smoke

exposure on pediatric asthma. Retrospective review of sye and preservative food allergy

Andrew Nickels, M.D. 2013-2015 Megan Motosue, M.D. 2014-2016 Reducing the risk of fatal anaphylaxis: Understanding trends and identifying risk factors (Clinical position, Honolulu, HI) Bhavisha Patel, M.D. 2014-2016 Asthma and celiac disease (Currently private practice, Kish Health System) Noriyuki Ohkura, M.D.,Ph.D. 2015-2016 Roles of fungus-derived ribonucleases in asthma Erin Willits, M.D. 2015-2017 Bleeding and coagulation function in patients with AERD (aspirin exacerbated respiratory disease) Jay Jin, M.D., Ph.D. 2015-2018 The role of T-follicular helper cells in the development of hay fever Joshua Dorn, M.D. 2016-2018 Contribution of oxidative stress in AERD through measurement of urinary 8-isoprostane F2-alpha

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Caitlin McNulty, M.D. 2016-2018 Takayasu Nomura, M.D., Ph.D. 2017-2019

Mayo Graduate School

I have mentored research programs of the following graduate school students. The current status of mentees is described in the parenthesis.

Juhan Yoon 2003-2007 PhD thesis mentor Mechanisms of Eosinophil Innate Immunity

(Graduated with a PhD degree, currently a research scientist in industry in Korea)

Rosalyn A. Cabrera 2005 Lab rotation mentor Activation of eosinophil integrin by acidic proteins (Currently a postdoctoral fellow) Joseph J. Dolence 2007 Lab rotation mentor Molecular mechanisms involved in dendritic response to Th1- and Th2-activating innate stimuli (Currently an Assistant Professor) June Ham 2009 Lab rotation mentor Regulatory mechanisms of early Th2 cell development (Currently a postdoctoral fellow) Chien-Chang Chen 2010-2016 PhD thesis mentor Mechanism of Th2-type airway inflammation (Graduated with a PhD degree,Currently a postdoctoral fellow) Erik L. Anderson 2011-2016 PhD thesis mentor Roles of IL-33 in allergic immune responses and its regulatory mechanisms (Graduated with a PhD degree, Currently a medical school student) Kathleen Bartemes 2011-2015 PhD thesis mentor Regulatory of innate type 2 immune response (Graduated with a PhD degree. Currently a post doc in the Allergy Research Lab) Luz Cumba-Garcia 2016 Lab rotation mentor

Roles of full-lengths and processed IL-33 in airway Inflammation (Currently a Mayo Graduate School Student)

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James Krempsky 2016-current PhD thesis mentor Immunological mechanisms for development of peanut allergy

Mayo Graduate School Summer Undergraduate Research Fellowship I have mentored the following summer students. The current status of mentees is described in parenthesis.

Alexia Passe 1995, 1996 Eosinophil interaction with matrix proteins. (Currently a physician) Shannon McKinney 1997 Roles of PLA2 for eosinophil activation. Lee Wright 2000 Roles of complements in eosinophil activation. Darren McDonald 2000 Effects of steroids on eosinophil functions. (Currently a surgeon at Mayo Clinic) Kate Cooper 2001 Eosinophil response to secretory IgA Lama Nysse 2004 Role of mast cell products on eosinophil migration (Currently a dental school student) Robert M. Mocharla 2005 Basophil-specific monoclonal antibody (Currently a medical school student) Wade G. Swenson 2006 Role of mast cells in innate immunity (Currently a medical school student) Mitra Naseri 2007 Role of Apo-A1 in activation of dendritic cells (Currently a graduate school student) Stephen Nelson 2008 Mechanisms of allergy immunotherapy with anti B7-DC antibody (Currently a graduate school student) Wing Lam 2009 Regulatory mechanisms of IL-33-induced development of Th2 cells (Currently an undergraduate student at Carleton College) Winter Okoth 2010, 2011 Expression of cytokine receptors in innate Th2 cells in the lungs

(Currently an undergraduate student at Thomas More College)

Adam Schaenzer 2012 Development of a mast cell bioassay for quantifying

functional activity of human IL-33

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(Currently an undergraduate student at Milwaukee School of Engineering)

Ashli Moore 2015 Analysis of antigen presenting cells following airborne

peanut exposure

D. Educational Scholarship

1. Director of NIH Institutional Training Grant, T32 AI07047, “Training Grant in Allergic Diseases” since 2000

2. Recipient of Non-restrictional Research Fellowship Grant from Sunstar, Inc.

E. Honors and Awards for Education

2011 Walter and Leonore Annenberg Professor of Pulmonary Medicine, Mayo Clinic, Rochester, MN 2014 Mayo Graduate School Dean’s Recognition Award

F. Academic Career Development

None

11. INSTITUTIONAL/DEPARTMENTAL ADMINISTRATIVE RESPONSIBILITIES, COMMITTEE

MEMBERSHIPS, AND OTHER ACTIVITIES

1999-present Research Chair, Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester

1999-present Chair, Research Committee, Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester

1999-2010 Internal Medicine Research Advisory Group Member 2002 Member, Research Equipment Subcommittee 2003-2013 Member, Mayo Foundation Graduate School Education Committee 2003-2008 Member, Institutional Animal Use and Care Committee (IACUC) 2003-present Track Director, Immunology Track, Mayo Graduate School 2004-2012 Director, Clinical Immunology and Immunotherapeutics Program (CIIP) Department of Medicine 2004-present Director, Federation of Clinical Immunology Societies (FOCIS) Center of Excellence at the Mayo Clinic

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2004-2011 Program Leader, Mayo Heart, Lung and Blood Theme, Airway Diseases

and Smoking Program

2005-2008 Vice Chair, Institutional Animal Use and Care Committee (IACUC) 2014-present Member, Research Personnel Subcommittee of the Mayo Clinic Research

Committee 2014-present Chair, Institutional Animal Use and Care Committee (IACUC)

12. PRESENTATIONS AT REGIONAL, NATIONAL, AND INTERNATIONAL MEETINGS

Invited Lectures/Presentations at International Meetings

1. Discussant in "Eosinophil Congress 1992", June 1-3, 1992, at Limerick, Ireland. Scientists working on eosinophils were invited to this 3 day symposium from all over the

world, and we discussed recent progress in eosinophil research. 2. Invited speaker in "Basophil and Eosinophil Symposium", March 9-14, 1994, at Cabo San Lucas,

Mexico. This symposium was organized by the American Academy of Allergy Asthma and Clinical

Immunology. Scientists from all over the world working on basophils and eosinophils were invited to the meeting. I delivered a talk, entitled “Tyrosine phosphorylation and inositol phosphate production: Are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG?”.

3. Invited speaker in “Eosinophil Workshop”, May 27-28, 1994, at Tokyo, Japan. Scientists working on eosinophils gathered from all over Japan in this symposium. I was

invited to the symposium, and gave a 1 hour plenary lecture, entitled “Mechanism of Eosinophil Activation in Diseases”.

4. Moderator of a scientific session at an international meeting, “Asthma Theory and Treatment 95”,

July 15-17,1995. at Chicago, IL, USA. This international meeting was organized by a joint effort of the American Academy of

Allergy Asthma and Clinical Immunology, and the American Thoracic Society. Physicians and Scientists, working on asthma, attended the meeting from all over the world, and I was invited to moderate a scientific session.

5. Invited speaker of an international conference, “Lung Cell Biology Symposium”, November 5-

8,1995, at Cape Cod, MA, USA. This international conference was sponsored by Boston University School of Medicine, and

approximately 25 scientists, who are working on pulmonary research were invited to the meeting from all over the world, including U.S.A., France, Germany, Canada, and England. I gave a 30 minute talk entitled, “Fc-receptor Mediated Activation of Eosinophils in Allergic Diseases”.

6. Invited presenter at an international conference, “International Respiratory Forum: Acute and

Chronic Inflammation in the Respiratory Tract”, November 10, 1995, London, UK.

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This international meeting was organized by Glaxo Company. Approximately 30 scientists working on bronchial asthma were invited from U.S.A. and Europe to present their work to approximately 500 pulmonary physicians and scientists. I presented a poster and a talk, entitled “Fluticasone Propionate is the Most Potent Glucocorticoid in the Induction of Apoptosis of Eosinophils.

7. Moderator of a seminar at “53rd International Meeting of American Academy of Asthma, Allergy

and Immunology”, March 15-20, 1996, at New Orleans, LA. I moderated a 90 minute scientific session, and give a seminar entitled “Eosinophil Signal

Transduction”. 8. Symposist at “XIVth International Congress for Tropical Medicine and Malaria”, November 17-22,

1996, at Nagasaki, Japan. I presented a 20 minute talk entitled, “The Roles of Antigen-specific IgG and Adhesion

Molecules in Eosinophils Degranulation”, in a symposium session “Host Defense by Phagocytes”. 9. Moderator of a seminar at “The Joint Meeting of American Academy of Asthma, Allergy and

Immunology/American Association of Immunologists/Clinical Immunology Society”, February 21-27, 1997, at San Francisco, CA.

I moderated a 90 minute scientific session, entitled “Advanced Research Seminar: Signal Transduction”.

10. Symposist in MOA/CIS Symposium in “The Joint Meeting of American Academy of Asthma,

Allergy and Immunology/American Association of Immunologists/Clinical Immunology Society”, February 21-27, 1997, at San Francisco, CA.

I delivered a 30 minute talk, entitled “Eosinophils as a Source of Cytokine” and discussed the cellular interaction of inflammatory cells in allergic reaction.

11. Invited Speaker at “The Fatal Asthma Workshop”, March 15-16, 1997, at Boston, MA. I gave a 30 minute talk entitled “Eosinophil/PMN Contribution to Fatal Asthma” and

discussed the roles of eosinophils and neutrophils in fatal asthma. This meeting was organized by the American Academy of Asthma, Allergy and Immunology and Dr. Scheller, Brigham/Women’s Hospital, Boston, MA. Experts on asthma were invited internationally.

12. Invited Speaker at “The 2nd International Symposium: Frontiers in Allergy”, September 5-6, 1997,

at Mainz, Germany. I am invited to give a 45 minute lecture on “Regulatory Mechanisms of Eosinophil

Degranulation”. This is an international symposium in which 20 experts in the field of allergy were invited and gave lectures at the Johannes Gutenberg-Universitat Mainz. The audience was approximately 100 physicians and scientists.

13. Invited Speaker at “Symposium: New Topics in Allergy”, July 24, 1997, at Osaka, Japan. I gave a 60 minute lecture on “Regulatory Mechanisms of Eosinophils by Fc Receptors and

Adhesion Molecules”. This is a Japanese national symposium held annually, in which physicians and clinical investigators nationwide gather and discuss the recent progress in the fields of allergy and clinical immunology.

14. Invited Special Speaker at “2nd Tokyo Allergy Symposium”, September 12, 1997, at Tokyo, Japan.

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I gave a 60 minutes lecture, entitled “The Roles and Mechanisms of Eosinophilic Inflammation in Allergic Diseases”. This is a Japanese national symposium in the field of allergy and clinical immunology and held annually. The audience was 300 physicians and scientists.

15. Invited as a moderator of a seminar at “54th International Meeting of American Academy of

Asthma, Allergy and Immunology”, March 13-18, 1998, at Washington, DC. I moderated a 90 minute scientific session, and give a seminar entitled “Eosinophils:

Markers and Function in Allergic Inflammation.” 16. Invited as a co-chairman and a speaker of symposium at “54th International Meeting of American

Academy of Asthma, Allergy and Immunology”, March 13-18, 1998, at Washington, DC. I co-moderated a 2 hour symposium, entitled “Molecular Mechanisms of Eosinophil

Recruitment”, and give a talk entitled “Multiple Molecular Mechanisms Involved in Eosinophil Recruitment”.

17. Invited as a moderator of a seminar at “55th International Meeting of American Academy of

Asthma, Allergy and Immunology”, February 26-March 3, 1999, at Orlando, Florida. I moderated a 90 minute scientific session, and gave a seminar entitled “Eosinophils:

Markers and Function in Allergic Inflammation.” 18. Invited as a co-chairman and a speaker of symposium at “55th International Meeting of American

Academy of Asthma, Allergy and Immunology”, February 26-March 3, 1999, at Orlando, Florida. I co-moderated a 2 hour symposium, entitled “New Concepts in Eosinophil Biology”, and

give a talk entitled “Synergistic Interactions of Autocrine Mediators and Adhesion Molecules during Activation of Eosinophils”.

19. Invited as a speaker at “Symposium on the Inflammatory Mechanisms of Asthma”, July 24, 1999,

Tokyo, Japan. This meeting is organized by a section of the Ministry of Health, Japan. I gave a 60 minutes lecture, entitled "Roles and Activation of Eosinophils in Allergic

Diseases and Bronchial Asthma". 20. Invited as a speaker to ”Eosinophil 1999”, October 3-5, 1999, Lund, Sweden. This meeting is held annually at various places in the world to discuss the progress in the

field of eosinophil biology. I will give a talk entitled “Mechanisms of Eosinophil Granule Release”. 21. Invited as a speaker to "British Society of Immunology/British Society of Allergy and Clinical

Immunology Joint Meeting", November 30-December 3, 1999, at Harrogate, UK. This is an annual official meeting of the British Society of Immunology and the British

Society of Allergy and Clinical Immunology. I was invited to a symposium session, and gave a 30 minute talk, entitled "Cellular and Intracellular Mechanisms of Eosinophil Degranulation".

22. Invited as a symposium speaker to "56th International Meeting of the American Academy of

Allergy and Clinical Immunology", March 3-8, 2000, San Diego, CA. This is an annual official meeting of the American Academy of Allergy Asthma and

Immunology. I was invited to a symposium session, and gave a 30 minute talk, entitled "The eosinophil synthesizes and releases nerve growth factor".

23. Invited as a co-chairman and a speaker of symposium to “56th International Meeting of American

Academy of Asthma, Allergy and Immunology”, March 3-8, 2000, San Diego, CA.

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I co-moderated a 2 hour symposium, entitled “Leukocyte signal transduction in allergy”, and give a talk entitled “Intracellular mechanisms leading to mediator release from eosinophils”.

24. Invited as a plenary session speaker to "The 9th Congress of International Rhinology Society",

September 20-23, 2000, Washington, DC. I was invited to a plenary session, "What is the etiology of chronic rhinosinusitis", and gave

a 20 minutes talk, entitled "The role of eosinophilic inflammation in chronic rhinosinusitis", in front of approximately 2,000 audiences.

25. Invited as a speaker of special lecture to the annual meeting of "The Korean Society of Pediatric

Allergy and Respiratory Diseases", October 20, 2000, Seoul, Korea. I gave a 60-minute formal lecture, entitled "Mechanisms of eosinophilic inflammation in

asthma and allergic diseases, in from of approximately 300 audiences. 26. Invited as a speaker of special lecture to the annual meeting of "The Japanese Society of Pediatric

Allergy", November 2-3, 2000, Maebashi, Japan. I gave a 45-minute formal lecture, entitled "Roles and mechanisms of eosinophilic

inflammation in bronchial asthma". The audience was approximately 1,500.

27. Invited as a speaker of course to “The 57th International Meeting of American Academy of Asthma, Allergy and Immunology”, March 16-21, 2001, New Orleans, Louisiana

I gave a 20-minutes lecture, entitled "Eosinophil biology/mediators" as a part of the Immunology Review Course: Immunologic Mechanisms of Allergy. The audiences were approximately 200 clinicians, fellows, and students.

28. Invited as a speaker to “Eosinophil 2001 Symposium”, May 4-8, 2001, Banff, Alberta, Canada. I gave a 20-minutes lecture, entitled “Regulatory mechanisms of human eosinophil

degranulation”. The audiences were approximately 150 researchers, clinicians, and fellows. 29. Invited as a speaker to “The 7th International Congress on Platelet Activating Factor and Lipid

Mediators’, September 24-27, 2001, Tokyo, Japan. I gave a 25-minutes lecture, entitled “Eosinophil activation by platelet activating factor”. The

audiences were approximately 200 scientists and clinicians. 30. Invited as a co-chairman of symposium to “The 58th International Meeting of American Academy

of Asthma, Allergy and Immunology”, March 1-6, 2002, New York, NY. I co-moderated a 2 hour symposium, entitled “Eosinophils”. 31. Invited as a symposium speaker to “ The 58th International Meeting of American Academy of

Asthma, Allergy and Immunology”, March 1-6, 2002, New York, NY. This is an annual official meeting of the American Academy of Allergy Asthma and

Immunology. I was invited to a symposium session "Recent Advances in the Etiology of Sinusitis", and gave a 30 minute talk, entitled "Fungi as a Cause of Sinusitis".

32. Invited as a co-chairman of seminar to “The 59th International Meeting of American Academy of

Asthma, Allergy and Immunology”, March 7-12, 2003, Denver, CO. I co-moderated a 2 hour symposium, entitled “Role of eosinophils in chronic sinusitis”.

33. Invited as a speaker to “Eosinophil 2003 Symposium”, June 25-29, 2003, Aspen, CO.

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I gave a 20-minute lecture, entitled “Role of innate immunity in activation of human eosinophils”. The audiences were approximately 200 researchers, clinicians, and fellows

34. Invited as the chairman of symposium to “The 60th International Meeting of American Academy of

Asthma, Allergy and Immunology”, March 19-23, 2004, San Francisco, CA. I moderated a 2 hour symposium, entitled “Why do allergies persist?”. 35. Invited as a speaker at the “The 22nd Aspen Allergy Conference”, July 27-31, 2004, Aspen, CO. I gave a 45-minute talk, entitled “Fungi are among us. Is the role of fungi in CRS myth or

reality? 36. Invited as a co-chairman of seminar to “The 61st International Meeting of American Academy of

Asthma, Allergy and Immunology”, March 18-22, 2005, San Antonio, TX. I co-moderated a 1 hour symposium, entitled “Effector functions of eosinophils in allergic

inflammation”. 37. Invited as a symposium speaker to “The 12th International Congress of Immunology and 4th

Annual Conference of FOCIS”, July 18-23, 2004. In the symposium session titled; Mast cell, eosinophils, allergic inflammation. I gave a 30 minute talk entitled: Role of eosinophils in innate immunity and allergic inflammation.

38. Invited as a speaker at the “The 4th Congress of the International eosinophil Society”, May 25-29,

2005, Bern, Switzerland. I gave a 20-minute talk, entitled “Roles of eosinophils in innate immunity to fungi and

allergic inflammation”. 39. Invited as a plenary session speaker at the “The 55th Annual Meeting of the Japanese Society of

Allergology”, October 20-22, 2005, Morioka, Japan. I gave a 60-minute talk, entitled “New insights into the eosinophil functions”. 40. Invited as a symposium speaker at the “International Symposium on Eosinophils and Other

Inflammatory Cells in Allergy”, October 23, 2005, Akita, Japan. I gave a 30-minute talk, entitled “New insights into the eosinophil functions”. 41. Invited as a plenary session speaker at the “The Annual Meeting of the Canadian Society of

Allergy and Clinical Immunology”, September 22-25, 2005, Winnipeg, Canada. I gave a 60-minute talk, entitled “Clinical consideration of the rhinosinusitis”. 42. Invited as a workshop speaker at the “Ocular Allergy Workshop”, October 4-6, 2006, Ettal,

Germany I gave a 30-minute talk, entitled “Role of eosinophils in allergy and immunity”. 43. Invited as a workshop speaker at the “The 5th Congress of the International eosinophil Society”,

July 18-22, 2007, Snowbird, Utah. I gave a 20-minute talk, entitled “Innate and acquired immune responses to environmental

fungi and their potential roles in human chronic airway disease”. 44. Invited as a symposium speaker at the “World Allergy Congress 2007”, December 2-6, 2007,

Bangkok, Thailand. I gave a 20-minute talk, entitled “Role of eosinophils in health and disease”.

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45. Invited as a workshop speaker at the “Fungal Sinusitis”, February 9-11, 2008, Chandigarh, India. I gave two 20-minute talks, entitled “Use of animal model in understanding fungal sinusitis”

and “Novel biomarker and newer diagnostic techniques for fungal sinusitis”. 46. Invited as a workshop speaker at the “The 6th Congress of the International eosinophil Society”,

July 7-11, 2009, Bruges, Belgium I gave a 20-minute talk, entitled “Roles of epithelial alarmin IL-33 in eosinophilic

inflammation”. 47. Invited as a workshop speaker at the “Mucosal Immunity Workshop”, October 8-11, 2009,

Trudeau Institute, Saranac Lake, NY. 48. Invited as a plenary session speaker at the “The 59th Annual Meeting of the Japanese Society of

Allergology”, October 28-30, 2009, Akita, Japan. I gave a 60-minute talk, entitled “Roles of the epithelial alarmin IL-33 in eosinophilic

inflammation”. 49. Invited as a symposium speaker at the “International symposium; eosinophils, other inflammatory

cells, and molecules in allergy”, October 31, 2009, Akita, Japan. I gave a 30-minute talk, entitled “Eosinophils survey dangers in and out”. 50. Invited as a speaker at the “AAI Advanced Course in Immunology”, July 26-30, 2010, Minneapolis,

Minnesota. I gave a 90-minute lecture, entitled “Allergy and Asthma”. 51. Invited as a plenary session speaker at the “Annual Meeting of the Korean Society of Pediatric

Allergy,” October 23, 2010, Seoul, South Korea. I gave a 60-minute talk, entitled “Mechanisms involved in development of Th2-type immunity

to airborne allergens”. 52. Invited as a symposium speaker at the “International symposium on host defense and immunity”,

January 14-15, 2011, Mie, Japan. I gave a 40-minute talk, entitle “Role of mucosal danger signal in development of Th2-type

immune responses. 53. Invited as a workshop speaker at the “2011 Annual Meeting of American Academy of Asthma,

Allergy and Immunology”, March 18-22, 2011, San Francisco, CA. I gave a 20-minute talk, entitled “Eosinophils sensing exogenous and endogenous dangers”. 54. Invited as a workshop speaker at the “The 7th Congress of the International eosinophil Society”,

June 21-24, 2011, Quebec city, Canada I gave a 20-minute talk, entitled “A novel lymphoid cell subset mediates Th2-type immunity

and eosinophilic inflammation to inhaled allergens”. 55. Invited as a speaker at the “AAI Advanced Course in Immunology”, August 1-5, 2011, Minneapolis,

Minnesota. I gave a 90-minute lecture, entitled “Allergy and Asthma”.

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56. Invited as a plenary session speaker at the “International Rhinology Society and International Symposium on Infection and Allergy of the Nose”, September 19-23, 2011, Tokyo, Japan.

I gave a 60-minute lecture, entitled “Eosinophilic Rhinosinusitis”. 57. Invited as a plenary session speaker at the “30th Annual Meeting of the Japan Society of

Immunology and Allergology in Otolaryngology”, February 16-18, 2012, Shiga, Japan. I gave a 60-minute lecture, entitled “Role of airway epithelium in Th2-type immuninty”. 58. Invited as a symposium speaker at the “2012 Annual Meeting of American Academy of Asthma,

Allergy and Immunology”, March 1-5, 2012, Orlando, CA. I gave a 25-minute talk, entitled “Epithelia cell-dendritic cell interaction in the airway

mucosa”. 59. Invited as a plenary session speaker at the “24th Annual Spring Meeting of the Japanese Society

of Allergology”, May 10-14, 2012, Osaka, Japan. I gave a 60-minute lecture, entitled “Roles of eosinophils and Alarmins in airway

inflammation”. 60. Invited as a symposium speaker at the “2012 Congress of European Society of Allergy Asthma

and Clinical Immunology”, June 16-20, Geneva, Switzerland. I gave a 30-minute talk, entitled “Regulation of T cell subsets by airway epithelium and

epithelium-derived cytokines”. 61. Invited as a plenary session speaker at the “2012 Workshop on Eosinophils in Allergy and Related

Diseases”, June 23, 2012, Tokyo, Japan. I gave a 60-minute lecture, entitled “Roles of eosinophils in human diseases”. 62. Invited as a plenary session speaker at the “Rochester Conference”, June 27, 2012, Tokyo, Japan. I gave a 60-minute lecture, entitled “Role of innate type 2 immunity in asthma and allergic

diseases”. 63. Invited as a plenary session speaker at the “62th Annual Meeting of the Japanese Society of

Allergology”, November 29-Decemer 1, 2012, Osaka, Japan. I gave a 60-minute lecture, entitled “Mechanisms of airway immunity and its roles in asthma

and allergic diseases”. 64. Invited as a plenary session speaker at the “2012 Workshop on Severe and Aspirin-sensitive

asthma”, December 1, Osaka, Japan. I gave a 60-minute lecture, entitled “Innate and adaptive immunological mechanisms of

eosinophilic airway inflammation”. 65. Invited speaker at AAI Publications Committee Symposium, “Editor’s Choice: The JI 2012”, at

IMMUNOLOGY2013, AAI Annual Meeting, May 3-7, 2013, Honolulu, HI. I gave a 30-minute talk, entitled “Innate type 2 lymphoid cells in immunity and allergic airway

inflammation”. 66. Invited speaker, WAO Presidential Symposium, at European Academy of Allergy and Immunology

Congress 2013, June 22-26, 2013, Milan, Italy. I gave a 30-minute talk, entitled “Roles of eosinophils in mucosal immune responses”.

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67. Invited as a plenary session speaker at the “The 23rd Congress of Interasthma Japan/North Asia”, June 26-29, 2013, Tokyo Japan.

I gave a 60-minute lecture, entitled ”Implication of Innate Immune Response in Asthma”. 68. Invited as a workshop speaker at the “The 8th Congress of the International eosinophil Society”,

July 14-18, 2013, Oxoford, UK I gave a 30-minute talk, entitled “Type 2 innate lymphoid cells in pulmonary inflammation”. 69. Invited as a workshop speaker at the “2014 Annual Meeting of American Academy of Asthma,

Allergy and Immunology”, February 28-March 4, 2014, San Diego, CA. I gave a talk entitled “The importance of IL-25” at the Epithelium in Control Q & A Workshop. 70. Invited as a debate speaker at the “2014 Annual Meeting of American Academy of Asthma, Allergy

and Immunology”, February 28-March 4, 2014, San Diego, CA. I gave a “con” debate on the topic “Adaptive immune responses are essential”. 71. Invitited as a plenary session speaker at the “The 117th Annual Meeting for the Japan Pediatric

Society”, April 11-13, 2014, Nagoya, Japan. I gave a 60-minute talk, entitled “Roles of innate immune response in allergy”. 72. Invited as a presidential plenary session speaker at the “The 51st Annuma Meeting of the

Japanese Society of Pediatric Allergy and Clinical Immunology, November 8-9, 2014, Yokkaichi, Japan.

I gave a 30-minute talk, entitled “Immunological Mechanisms Involved in Development of Allergic Diseases: Critical Roles for Innate Immunity”.

73. Invited as a seminar speaker at the “The 51st Annuma Meeting of the Japanese Society of

Pediatric Allergy and Clinical Immunology, November 8-9, 2014, Yokkaichi, Japan. I gave a 25-minute talk, entitled “It is Exciting to Study Allergy!”. 74. Invited as a lecturer at the “2015 Annual Meeting of American Academy of Asthma, Allergy and

Immunology”, February 20-February 24, 2015, Houston, TX. I gave a talk entitled “Investing together in our future; Inaugural year”. 75. Invited as a lecturer at the “2015 Annual Meeting of American Academy of Asthma, Allergy and

Immunology”, February 20-February 24, 2015, Houston, TX. I gave a talk entitled “Development of follicular T cells and their roles in allergic responses”. 76. Invited as a lecturer at the “2015 Annual Meeting of American Academy of Asthma, Allergy and

Immunology”, February 20-February 24, 2015, Houston, TX. I gave a talk entitled “IL-33 and ILC2 and development of allergic sensitization”. 77. Invited as a lecturer at the “2015 Annual Meeting of American Academy of Asthma, Allergy and

Immunology”, February 20-February 24, 2015, Houston, TX. I moderated a talk entitled “Mechanisms of atopic diseases: Inflammation”. 78. Invited as a lecturer at the “Tackling Problematic Sinonasal Disease: Debates and Consensus

2015” meeting, March 11-March 14, 2015 in Phoenix, Arizona. I gave a talk entitled “Epithelial barrier dysregulation”.

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79. Invited as a lecturer at the “Tackling Problematic Sinonasal Disease: Debates and Consensus 2015” meeting, March 11-March 14, 2015 in Phoenix, Arizona.

I was a panelist for a talk entitled “Which tests I recommend after a diagnosis of CRS is confirmed”.

80. Invited as a symposium speaker at “12th World Congress on Inflammation”, August 8-12, 2015 in

Boston, MA. I gave a 30-minute talked entitled “Functions of IL-33 and ILC2s in controlling allergic airway

inflammation and asthma”. 81. Invited as a symposium speaker at Annual Janssen Immunology Symposium “Innate Lymphoid

Cells in Health and Disease”, Oct 6-7, 2015 in San Diego, CA. I gave a 45-minute talked entitled “Functions of IL-33 and ILC2s in controlling allergic airway

inflammation and asthma”. 82. Invited as a lecturer at the “Tackling Problematic Sinonasal Disease: Debates and Consensus

2015” meeting, March 31-April 2, 2016 in Phoenix, Arizona. I gave a talk entitled “The role of Staph Aureus, fungus and other microbes in CRS”. 83. Invited as a symposium speaker at the 31st Symposium of the Collegium Internationale

Allergologicum, April 3-8, 2016 in Chaleston, South Carolina. I gave a 17-minute talked entitled “Follicular helper T (Tfh) cells mediate IgE antibody

responses to airborne allergens”. 84. Invited as a plenary session speaker at the “The 65th Annual Meeting of the Japanese Society of

Allergology”, June 17-19, 2016 in Tokyo, Japan. I gave a 60-minute lecture, entitled “Pathogenesis of chronic rhinosinusitis”. 85. Invited as a special lecture speaker at the “The 26th Congress of Interasthma Japan/North

America”, September 17-18, 2016 in Fukuoka, Japan. I gave a 60-minute lecture, entitled “Airway epithelium in pathogenesis of asthma and

therapeutic potential”. 86. Invited as a symposium speaker at the “2017 Annual Meeting of American Academy of Asthma,

Allergy and Immunology”, March 3-6, Atlanta, GA. I gave a 30-minute talk entitled “Roles of follicular T cells in allergic diseases”. 87. Invited as a lecturer at the “Tackling Problematic Sinonasal Disease: Debates and Consensus

2017” meeting, March 29-April 1, 2017 in Phoenix, Arizona. I gave a talk entitled “Epithelial cytokines as the regulators of type 2 airway inflammation”. 88. Invited as a plenary session speaker at the “The 62nd Annual Meetingh of the Japanese Society for

Dialysis Therapy”, June 16-18, 2017 in Yokohama, Japan. I gave a 60-minutes lecture, enitled “The immunological mechanisms of peritoneal

sclerosis”.

Abstract/Poster Presentations at National and International Meetings

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1. Kita H, Abu-Ghazaleh RI, Gleich GJ: Effect of corticosteroid on immunoglobulin-induced eosinophil (EOS) degranulation. The American Academy of Allergy and Immunology. 46th Annual Meeting, 1989. San Antonio. USA.

2. Fujisawa T, Abu-Ghazaleh RI, Kita H, Mestecky J, Sanderson CJ, Gleich GJ: Regulatory effect of

cytokines on eosinophil degranulation. The American Academy of Allergy and Immunology. 46th Annual Meeting. 1989. San Antonio, TX, USA.

3. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT: Regulation of immunoglobulin-induced

eosinophil degranulation by cAMP. The American Academy of Allergy and Immunology. 47th Annual Meeting. 1990. Baltimore, MD, USA.

4. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT: Inhibition of human eosinophil degranulation

by pertussis toxin. Annual Meeting of The American Association of Immunologists. 1990. New Orleans, LA, USA.

5. Sedgwick JB, Calhoun WJ, Kita H, Gleich GJ, Busse WW: The effect of antigen (Ag) challenge on

the properties of airway eosinophils (EOS). Annual Meeting of The American Thoracic Society. 1990. Boston, MA, USA.

6. Goronzy, Weyand C, Lundy S, Mayeno A, Kita H, Gleich GJ: Analysis of implicated and

nonimplicated L-tryptophan (LT) lots in a patient with eosinophilia an myalgia syndrome (EMS). Annual Meeting of The American College Rheumatol. 1990. Seattle, WA, USA.

7. Gleich GJ, Leiferman KM, Kita H, Abu-Ghazaleh RI, Abraham RT, Hamman KJ, Baker RL:

Eosinophil degranulation and its consequences: The International Congress on Inflammation. 1990. Barcelona, Spain.

8. Kita H, Abu-Ghazaleh RI, Sanderson CJ, Gleich GJ: Human eosinophils cultured with human

interleukin 5 are hypodense, activated and have a distinctive morphology. The American Academy of Allergy and Immunology. 48th Annual Meeting. 1991. San Francisco, CA, USA.

9. Okubo Y, Kita H, Abrams J, Gleich GJ: Measurement of IL-5 by the eosinophil survival assay. The

American Academy of Allergy and Immunology. 48th Annual Meeting. 1991. San Francisco, CA, USA.

10. Wallen ND, Weiler DA, Gleich GJ, Kita H: Glucocorticoids (GC) inhibit rIL-5-enhanced in vitro

survival of eosinophils. The American Academy of Allergy and Immunology. 48th Annual Meeting. 1991. San Francisco, CA, USA.

11. Kita H, Weiler DA, Weyand CM, Goronzy JJ, Gleich GJ: Eosinophil-active cytokine from

mononuclear cells cultured with L-tryptophan products. Annual Meeting of The American Association of Immunologists. 1991. Atlanta, GA, USA.

12. Sur S, Kita H, Wagner J, Kephart G, George T, Leiferman KM, Gleich GJ: Localization of

eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophils. Annual Meeting of The American Association of Immunologists. 1991. Atlanta, GA, USA.

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13. Okubo Y, Kita H, Weiler D, Abrams J, Gleich GJ: Sensitivity of the eosinophil survival assay for IL-3, GM-CSF, and IL-5. Annual Meeting of The American Association of Immunologist. 1991. Atlanta, GA, USA.

14. Ohnishi T, Kita H, Sedgwick JB, Calhoun WJ, Busse WW, Abrams J, Gleich GJ. IL-5 is the

predominant eosinophil-active cytokine in the pulmonary antigen-induced late phase reaction. International Congress of Allergology and Clinical Immunology. 1991. Kyoto, Japan.

15. Ohnishi T, Kita H, Mayeno A, Sur S, Gleich GJ: Eosinophil-active cytokine and an inhibitor of

cytokine activity in the bronchoalveolar lavage fluids (BALF) of symptomatic patients with asthma. The American Academy of Allergy and Immunology. 49th Annual Meeting. 1992. Orlando, FL, USA.

16. Ide M, Okubo Y, Kita H, Weiler DA, Gleich GJ: Measurement of eosinophil viability: Comparison of

the MTT assay and fluorescent microscopy. The American Academy of Allergy and Immunology. 49th Annual Meeting. 1992. Orlando, FL, USA.

17. Kita H, Ohnishi T, Okubo Y, Weiler DA, Abrams JS, Gleich GJ: GM-CSF and IL-3 release from

human peripheral blood eosinophils. The American Academy of Allergy and Immunology. 49th Annual Meeting. 1992. Orlando, FL, USA.

18. Kita H, Horie S, Okubo Y, Weiler D, Gleich GJ: Pharmacologic modulation of eosinophil

degranulation. The American Academy of Allergy and Immunology. 50th Annual Meeting. 1993. Chicago, IL, USA.

19. Horie S, Gleich GJ, Weiler DA, Kita H: Regulation of eosinophil degranulation by cytokines and

lipid mediators. The American Academy of Allergy and Immunology. 50th Annual Meeting. 1993. Chicago, IL, USA.

20. Ide M, Weiler DA, Kita H, Gleich GJ: Eosinophil purification: Comparison of magnetic cell sorting

and percoll density gradient centrifugation. The American Academy of Allergy and Immunology. 50th Annual Meeting. 1993. Chicago, IL, USA.

21. Weiler D, Kita H, Okubo Y, Ide M, Gleich GJ: Hypereosinophilic syndrome, toxic oil syndrome

and eosinophilia-myalgia syndrome: Hypodense eosinophils and cytokines. The American Academy of Allergy and Immunology. 50th Annual Meeting. 1993 Chicago, IL, USA.

22. Ohnishi T, Weiler D, Mayeno A, Kita H, Gleich GJ: An inhibitory serum factor for eosinophil active

cytokines: Association with siliconized tubes from one company. The American Academy of Allergy and Immunology. 50th Annual Meeting. 1993. Chicago, IL, USA.

23. Sedgwick JB, Ohnishi T, Kita H, Gleich GJ, Calhoun WJ, Jarjour N, Busse WW: Comparison of

segmental bronchoprovocation (SBP) with allergen (AG) of asthma and allergic patients: 48 HR eosinophil (EOS) and cytokine response. The American Academy of Allergy and Immunology. 50th Annual Meeting. 1993. Chicago, IL, USA.

24. Chen K-R, Pittelkow MR, Kita H, Gleich GJ, Leiferman LM: Cytotoxicity of eosinophil granule

proteins to endothelial cells. Annual Meeting of The Society for Investigative Dermatology. 1993. Boston, MA, USA.

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25. Kita H, S Sur, Gleich GJ: Autocrine activation of eosinophils by eosinophil granule proteins. Annual Meeting of The American Association of Immunologists. 1993. Denver, CO, USA.

26. Horie S, Gleich GJ, Kita H: Mac-1 (CD11b/CD18) mediates degranulation of human eosinophils

induced by rhGM-CSF and platelet activating factor. The American Academy of Allergy and Immunology. 51st Annual Meeting. 1994. Anaheim, CA, USA.

27. Kita H, Horie S, Gleich GJ: Laminin and fibronectin inhibit adhesion and degranulation of

eosinophils. The American Academy of Allergy and Immunology. 51st Annual Meeting. 1994. Anaheim, CA, USA.

28. Kaneko M, Swanson M, Gleich GJ, Kita H: Ragweed-specific IgG1 induces degranulation of

eosinophils in bronchial asthma. The American Academy of Allergy and Immunology. 51st Annual Meeting. 1994. Anaheim, CA, USA.

29. Hagan J, Batemes K, Kita H, Ottesen E, Awadzi K, Nutman T, Gleich GJ: Eosinophil viability

enhancing activity preceding posttreatment eosinophilia in onchocerciasis. The American Academy of Allergy and Immunology. 51st Annual Meeting. 1994. Anaheim, CA, USA.

30. Martin LB, Gleich GJ, Swanson MC, Kita H: Normal human peripheral blood mononuclear cells

produce interleukin 5 following in vitro stimulation with interleukin 2. The American Academy of Allergy and Immunology. 51st Annual Meeting. 1994. Anaheim, CA, USA.

31. Nakajima H, Loegering DA, Kita H, Gleich GJ: Reactivity of monoclonal antibodies EG1 and EG2

with eosinophils and their granule proteins. Annual Meeting of The American Association of Immunologists. 1994. Anaheim, CA, USA.

32. Martin LB, Gleich GJ, Kita H: T-lymphocyte enriched peripheral blood mononuclear cells respond

to interleukin 2 stimulation by producing interleukin 5. Annual Meeting of The American Association of Immunologists. 1994. Anaheim, CA, USA.

33. Horie S, Gleich GJ, Kita H: Transforming growth factor beta induces the cell death of eosinophils.

Annual Meeting of The American Association of Immunologists. 1994. Anaheim, CA, USA. 34. Kato M, Abraham RT, Gleich GJ, Kita H: Role of tyrosine kinases in human eosinophil

degranulation. Annual Meeting of The American Association of Immunologists. 1994. Anaheim, CA, USA.

35. Kaneko M, Weiler D, Swanson M, Gleich GJ, Kita H: Antigen-dependent release of TNF-_ from

PBMC augments eosinophil degranulation in vitro. Annual Meeting of The American Association of Immunologists. 1994. Anaheim, CA, USA.

36. Sur S, Gleich GJ, Weiler DA, Sarkar G, Kita H, Hunt LW: Eosinophil recruitment after pulmonary

allergen challenge in patients with asthma is specifically associated with upregulation of IL-5 mRNA expression. International Conference, American Thoracic Society. 1994. Boston, MA, USA.

37. Kita H, Sur S, Hunt LW, Edel ES, Weiler DA, Swanson M, Ramsel R, Abrams JS, Gleich GJ:

Localized cytokine production and functional modulation of eosinophils in eosinophilic pneumonitis. International Conference, American Thoracic Society. 1994. Boston, MA, USA.

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38. Nakajima H, Gleich GJ, Kita H: Cytokine gene expression and protein synthesis from eosinophils stimulated by immunoglobulin (Ig). The American Academy of Allergy and Immunology. 52st Annual Meeting. 1995. New York, NY, USA.

39. Kato M, Abraham RT, Gleich GJ, Kita H: Enhanced phosphoinositide turnover and protein tyrosine

phosphorylation in adherent eosinophils. The American Academy of Allergy and Immunology. 52nd Annual Meeting. 1995. New York, NY, USA.

40. Kaneko M, Jarjour NN, Swanson M, Busse WW, Gleich GJ, Kita H: Allergen-specific IgG and IgA

in bronchoalveolar lavage (BAL) fluids from patients with allergy induce eosinophil degranulation. The American Academy of Allergy and Immunology. 52nd Annual Meeting. 1995. New York, NY, USA.

41. Kita H, Kaneko M, Frigas E, Bartemes KR, Weiler DA, Gleich GJ. Eosinophils from hay fever

patients degranulate in response to IgG, but not to IgE. The American Academy of Allergy and Immunology. 52nd Annual Meeting. 1995. New York, NY, USA.

42. Kaneko M, Horie S, Kato M, Gleich GJ, Kita H: IgG-induced eosinophil degranulation is dependent

on cellular adhesion through CD11b/18. International Conference, American Thoracic Society. 1995. Seattle, WA, USA.

43. Nagata M, Sedgwich JB, Kita H, Busse WW. Adhesion to VCAM-1 and exposure to GM-CSF

synergistically activate eosinophil (EOS) superoxide anion (O2-) generation and degranulation.

International Conference, American Thoracic Society. 1995. Seattle, WA, USA. 44. Kita H, Kaneko M, Jarjour NN, Swanson M, Busse WW, Gleich GJ: Allergen-specific IgG in sera

and bronchoalveolar lavage (BAL) fluids from patients with allergy induce eosinophil degranulation. Asthma Theory and Treatment 95. 1995. Chicago, IL, USA.

45. Kaneko M, Schimming AW, Bartemes KR, Gleich GJ, Kita H: Mast cells are not playing a role in

eosinophil accumulation induced by allergen in vivo. The American Academy of Allergy and Immunology. 53rd Annual Meeting. 1996. New Orleans, LA, USA.

46. Kita H, Weiler DA, Bartemes KR, Abrams JS, Gleich GJ: Spontaneous survival of eosinophils and

IL-5 levels in patients with idiopathic hypereosinophilic syndrome (HES). The American Academy of Allergy and Immunology. 53rd Annual Meeting. 1996. New Orleans, LA, USA.

47. Kim J-T, Gleich GJ, Kita H: Cross-linking of CD9 induces degranulation, GM-CSF production and

survival of human eosinophils. The American Academy of Allergy and Immunology. 53rd Annual Meeting. 1996. New Orleans, LA, USA.

48. Nakajima H, Gleich GJ, Kita H: Eosinophils express and produce IL-4, IL-8, and IL-10 - Evidence

for stored and newly synthesized cytokine. The American Academy of Allergy and Immunology. 53rd Annual Meeting. 1996. New Orleans, LA, USA.

49. Ohashi H, Ishikawa M, Kita H, Gleich GJ, Kawai H, Osawa T: Effects of protein kinase inhibitors

on eosinophil degranulation induced by secretory IgA (sIgA) conjugated Sepharose beads. The American Academy of Allergy and Immunology. 53rd Annual Meeting. 1996. New Orleans, LA, USA.

30

50. Nagata M, Sedgwick JB, Kita H, Busse WW: Eosinophil (Eos) interaction with ICAM-1 promotes release of superoxide anion (O2

-), Eos-derived neurotoxin (EDN) and LTC4. The American Academy of Allergy and Immunology. 53rd Annual Meeting. 1996. New Orleans, LA, USA.

51. Kato M, Abraham RT, Gleich GJ, Kita H: Cross-linking and clustering of Mac-1 (M2) molecules

induces activation and degranulation of human eosinophils. International Conference, American Thoracic Society. 1996. New Orleans, LA, USA.

52. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM: Mechanisms of eosinophil transmigration

through basement membrane component in vitro. International Conference, American Thoracic Society. 1996. New Orleans, LA, USA.

53. Levy AM, Kita H, Sandborn WJ, Phillips SF, Gleich GJ: Eosinophil granule protein concentration in

serum, urine and stool as indicators of disease activity in eosinophilic gastroenteritis. 96th Annual Meeting of the American Gastroenterological Association. 1996. San Francisco, CA.

54. Levy AM, Dubravec V, Kita H, Dyer D, Schkade PA, Phillips SF, Gleich GJ: Daily ingestion of

shiitake mushrooms is associated with eosinophilia, elevated serum IL-5 levels, increased stool eosinophil granule proteins and gastrointestinal symptoms. 96th Annual Meeting of the American Gastroenterological Association. 1996. San Francisco, CA.

55. Ohashi H, Takei M, Kita H, Gleich GJ, Fukamachi H: Signal transduction induced by PAF, IL-5 and

secretory IgA conjugated to Sepharose beads (sIgA). The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

56. Kato M, Kimura H, Tachibana A, Tokuyama K, Morikawa A, Kita H: Activation of dual signaling

pathways by platelet activating factor (PAF) in human eosinophils. The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

57. Dunnette SL, Kita H, Reed CE, and Gleich GJ: Topical glucocorticoid treatment of ragweed hay

fever. II. Relationship of eosinophil-derived neurotoxin (EDN) and IL-5 to disease severity. The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

58. Kim J-T, Gleich GJ, Kita H: Bidirectional regulation of eosinophil survival and apoptosis of FcR.

The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

59. Motegi Y, Gleich GJ, Kita H: Eosinophils, but not neutrophils, are preferentially activated by

secretory IgA (sIgA) compared to serum IgA: Potential roles of secretory components (SC). The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

60. Schimming A, Gleich GJ, Kita H: Inhibition of eosinophil infiltration into peritoneal cavities of

allergen-challenged mice by lipopolysaccharide (LPS). The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

61. Passe A, Schimming A, Gleich GJ, Hamann KJ, Kita H: Tissue matrix glycosaminoglycan,

heparan sulfate (HS), enhances survival of eosinophils. The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

31

62. Jorgensen RK, Gleich GJ, Kita H, Reed CE. Topical glucocorticoid treatment of ragweed hay fever.

I. effects on IgE and IgA antibody production. The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

63. Dubravec VA, Dyer PD, Schkade PA, Kita H, Gleich GJ, Levy AM. Shiitake mushroom induced

eosinophilia: case report and pilot study. The American Academy of Allergy and Immunology. 54th Annual Meeting. 1997. San Francisco, CA, USA.

64. Bartemes KR, Gleich GJ, Kita H: Autocrine production of platelet-activating factor plays critical

roles in adhesion and effector function of eosinophils stimulated by immunoglobulins and IL-5. International Conference, American Thoracic Society. 1997. San Francisco, CA, USA.

65. Motegi Y, Kita H: Platelet-activating factor activates dual signaling pathways in human eosinophils.

The American Academy of Allergy and Immunology. 55th Annual Meeting. 1998. Washington, D.C, USA.

66. Volcheck GW, Gleich GJ, Kita H: Pro- and anti-inflammatory effects of beta adrenergic agonists

on eosinophil response to IL-5. The American Academy of Allergy and Immunology. 55th Annual Meeting. 1998. Washington, D.C, USA.

67. Bankers-Fulbright JL, Kephart GM, Loegering DA, Bradford AL, Okada S, Kita H, Gleich GJ:

Sulfonylureas inhibit the survival and activation of human eosinophils in vitro. International Conference, American Thoracic Society. 1998. Chicago, IL, USA.

68. Yamazaki K, Lindor KD, Batts KP, Suzuki K, Sato S, Kita H, Gleich GJ. Ursodeoxycholic acid

inhibits eosinophil degranulation in situ in primary biliary cirrhosis. The annual meeting of American Association for the Study of Liver Diseases. 1998. Chicago, IL, USA.

69. Yamazaki K, Gleich GJ, Kita H. Bile acids activate eosinophils in vitro. The annual meeting of

American Association for the Study of Liver Diseases. 1998. Chicago, IL, USA. 70. Hiraguri M, Kita H. Common and distinct activation mechanisms in eosinophils stimulated with IL-

5 and platelet-activating factor (PAF). The American Academy of Allergy and Immunology. 56th Annual Meeting. 1999. Orlando, FL, USA.

71. Kobayashi H, Kita H. Production, storage and release of nerve growth factors by human

eosinophils. The American Academy of Allergy and Immunology. 56th Annual Meeting. 1999. Orlando, FL, USA.

72. Kato M, Morikawa A, Kita H. Ligation of the β2 integrin triggers phosphorylation and

degranulation of human eosinophils. The American Academy of Allergy and Immunology. 56th Annual Meeting. 1999. Orlando, FL, USA.

73. Bankers-Fulbright JL, Williams MA, Kita H, Gleich GJ, O’Grady SM. Regulation of eosinophil

attack: PKC pla ys a ce ntra l role in s upe roxide production. Inte rna tiona l Confe re nce , Ame rica n Thoracic Society. 1999. San Diego, CA, USA.

32

74. Valyasevi MA, Kita H, Loegering DA, Checkel JL, Gleich GJ. Airway constriction after intratracheal instillation of human eosinophil granule proteins in mice. International Conference, American Thoracic Society. 1999. San Diego, CA, USA.

75. Shimizu T, Kita H. Mucin inhibits eosinophil activation. International Conference, American

Thoracic Society. 1999. San Diego, CA, USA. 76. Hunt LW, Frigas EF, Butterfield JH, Li JT, Patel A, Kita H, Offord KP, Gleich GJ. Nebulized

lidocaine prevents deterioration of pulmonary function following withdrawal of inhaled glucocorticoids. International Conference, American Thoracic Society. 1999. San Diego, CA, USA.

77. Muraki M, Gleich GJ, Morrison SL, Kita H. Recombinant antigen-specific IgG and IgA, but not IgE,

induces degranulation and superoxide production by human eosinophils. The American Academy of Allergy and Immunology. 56th Annual Meeting. 2000 San Diego, CA, USA.

78. Shimizu T, Kita H. Activated airway epithelial cells induce migration of eosinophils through

epithelial cell monolayer. The American Academy of Allergy and Immunology. 56th Annual Meeting. 2000 San Diego, CA, USA.

79. Iijima K, Bartemes KR, Kita H. Differential functional responses of eosinophils and neutrophils

adherent to intercellular adhesion molecule (ICAM)-1. International Conference, American Thoracic Society. 2000. Toronto, Canada.

80. Bartemes KR, Iijima K, Kita H. Contrasting adhesion and functional response to ICAM-1 by

eosinophils and neutrophils in vitro. Annual Meeting of the American Association of Immunologists. 2000, Seattle, WA, USA.

81. Bankers-Fulbright JL, Kita H, Gleich GJ, O'Grady SM. PKC plays a central role in eosinophil

NADPH oxidase regulation. Annual Meeting of the American Association of Immunologists. 2000, Seattle, WA, USA.

82. Shin S-H, Gleich GJ, Kita H: Abnormal immunologic responses to fungal antigens in patients with

chronic rhinosinusitis. The American Academy of Allergy and Immunology. 57th Annual Meeting. 2001 New Orleans, LA, USA.

83. Shimizu T, Kita H: Anti-inflammatory effects of heparin on human eosinophils. The American

Academy of Allergy and Immunology. 57th Annual Meeting. 2001 New Orleans, LA, USA. 84. Yunginger JW, Kita H, Jones RT, Saito K, Hefle SL, Taylor SL: Systemic allergic reactions

following ingestion of erythritol-containing foods and beverages. The American Academy of Allergy and Immunology. 57th Annual Meeting. 2001 New Orleans, LA, USA.

85. Sedgwick JB, Liu LY, Kita H, Busse WW: 7-Transmembrane receptor (7-TMR) chemokines

activate eosinophil (Eos) degranulation upon IL-5 priming. The American Academy of Allergy and Immunology. 57th Annual Meeting. 2001 New Orleans, LA, USA.

86. Miike S, Kita H: Roles of protease and protease-activating receptor (PAR) in activation of human

eosinophils. International Conference, American Thoracic Society. 2001. Chicago, IL, U.S.A.

33

87. Matsuura T, Adolphson C, Squillace D, Kita H, Gleich GJ: The effect of dexamethasone on development of eosinophils from umbilical cord blood mononuclear cells. International Conference, American Thoracic Society. 2001. Chicago, IL, U.S.A.

88. Sedgwick JB, Jansen KJ, Kita H, Busse WW: IL-5-dependent activation of eosinophil

degranulation by 7-transmembrane receptor chemokine. International Conference, American Thoracic Society. 2001. Chicago, IL, U.S.A.

89. Bankers-Fulbright JL, Gleich GJ, Kita H, O’Grady SM: NADPH oxidase-associated proton

currents regulate granulocyte depolarization independently of superoxide production. Annual Meeting of the American Association of Immunologists. Washington, D.C., USA.

90. Inoue Y, Shin S-H, Ponikau J, Kita H: The fungus, Alternaria, induces activation and

degranulation of human eosinophils. The American Academy of Allergy and Immunology. 58th Annual Meeting. 2002 New York, NY, USA.

91. Bartemes KR, Cooper K, Kita H: Enhanced survival and multiple gene expression in human

eosinophils exposed to soluble secretory IgA. The American Academy of Allergy and Immunology. 58th Annual Meeting. 2002 New York, NY, USA.

92. Kobayashi T, Iijima K, Kita H: Potential anti-inflammatory role of mouse eosinophils. The

American Academy of Allergy and Immunology. 58th Annual Meeting. 2002 New York, NY, USA. 93. Sedgwick JB, Jansen KJ, Kita H, Bartemes KR, Busse WW: Increased total cellular eosinophil-

derived neurotoxin (EDN) in eosinophils (Eos) from patients with allergic asthma (AA). The American Academy of Allergy and Immunology. 58th Annual Meeting. 2002 New York, NY, USA.

94. Cook EB, Stahl JL, Sedgwick JB, Jansen KJ, Kita H, Graziano F, Barney NP: Anti-IgE activated

conjunctival mast cells mediate upregulation of eosinophil adhesion to conjunctival epithelial cells and eosinophil degranulation. The American Academy of Allergy and Immunology. 58th Annual Meeting. 2002 New York, NY, USA.

95. Moro MH, Checkel JL, Ovyanikova IG, Kita H, Gleich GJ: Cathepsin B is required for maturation

of eosinophil major basic protein. Annual Meeting of the American Association of Immunologists. 2002, New Orleans, LA, USA.

96. Matsuura T, Bartemes KR, Squillace DL, Gleich GJ, Kita H: Surface expression of eosinophil

major basic protein (MBP) and eosinophil peroxidase (EPO), without apparent extracellular release, by activated human eosinophils. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

97. Kim CK, Kim SW, Kim YK, Kita H, Koh YY: Eosinophil cationic protein (ECP) and interleukin (IL)-

8 levels in bronchoalveolar lavage (BAL) from pediatric patients with acute asthma and acute bronchiolitis. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

98. Terada A, Iijima K, Kita H: CD9 physically associate with CD11b/CD18 integrin and regulates

adhesion and activation of human eosinophils. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

34

99. Inoue Y, Shin SH, Ponikau JU, Kita H: Novel calcium-dependent pathways in eosinophil interaction with secretory product(s) of the fungus Alternaria. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

100. Iijima K, Kobayashi T, Kita H: NK cell-dependent, airway-specific, innate eosinophilic response to

Alternaria in mice. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

101. Ponikau JU, Kephart GM, Kita H: Extensive degranulation of eosinophils in mucin, but not in the

tissue, of chronic rhinosinusitis patients. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

102. Stahl JL, Cook EB, Sedgwick JB, Kita H, Barney NP, Graziano FM: Olopatadine inhibits

conjunctival mast cell-mediated and fMLP stimulated eosinophil degranulation but not mast cell-mediated adhesion of IL-5 primed eosinophils. The American Academy of Allergy and Immunology. 59th Annual Meeting. 2003 Denver, CO, USA.

103. Lim KG, Kita H, Sherris D, Moore E, Patel A: Mechanism of cough in post-nasal drip. International

Conference, American Thoracic Society. 2003. Seattle, WA, U.S.A.

104. Kim CK, Hagan JB, Kita H: Eosinophilic airway inflammation as an underlying mechanism in certain patients with chronic cough but without asthma. International Conference, American Thoracic Society. 2003. Seattle, WA, U.S.A.

105. Juhn YJ, Kita H, DeBolt MF, Poland GA, Pankratz SV, Jacobson RM: Assessment of the

association between measles vaccine response and asthma status. The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004. San Francisco, CA, USA.

106. Sedgwick JB, Bartemes K, Kita H, Busse WW: Relationship of in vitro survival and eosinophil

derived neurotoxin (EDN) degranulation in blood and airway eosinophils (EOS) following segmental bronchoprovocation with allergen (SBP-AG). The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004. San Francisco, CA, USA.

107. Terada A, Kita H: Regulatory role of the carcinoembryonic antigen (CEA)-family molecules in the

innate eosinophil response to Staphylococcus aureus. The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004. San Francisco, CA, USA.

108. Kobayashi T, Iijima K, Kita H: Beneficial effects of eosinophils in colitis induced by dextran sulfate

sodium. The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004. San Francisco, CA, USA.

109. Brooks AM, Sedgwick JB, Jansen KJ, Kita H, Squillace D, Kennedy D, Busse WW: VLA-4

antagonist WAY160103 (WAY) inhibits VCAM-1 activated eosinophil (EOS) respiratory burst but promote eosinophil derived neurotoxin (EDN) degranulation. The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004 San Francisco, CA, USA.

110. Sherris DA, Ponikau JU, Weaver A, Frigas E, Kita H: Treatment of chronic rhinosinusitis with

intranasal Amphotericin B: A prospective, randomized, placebo-controlled trial. The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004 San Francisco, CA, USA.

35

111. Davis LJB, Ponikau J, Sherris DA, Plager DA, Kita H: Gene microarray analysis of CD4-positive T cells in chronic rhinosinusitis (CRS). The American Academy of Allergy and Immunology. 60th Annual Meeting. 2004 San Francisco, CA, USA.

112. Hagan JB, Frigas E, Wendland BI, Hanson CA, Severson RJ, Harris PA, Kim CK, Hunt LW, Kita

H: Reference values for induced whole sputum performed in a routine clinical laboratory. International Conference, American Thoracic Society. 2004. Orland, FL, U.S.A.

113. Kim CK, Volcheck GW, Kita H: Increase in airway eosinophilia and a Th1 cytokine during the

chronic asymptomatic phase in patients with asthma. International Conference, American Thoracic Society. 2004. Orland, FL, U.S.A.

114. Yamazaki K, Murray JA, Arora AS, Alexander JA, Butterfield JH, Smyrk TC, Kita H:

Immunological characterization of eosinophilic esophagitis: Allergen-specific cytokine production by peripheral blood mononuclear cells. Digestive Disease Week. 2004. New Orleans, LA, U.S.A.

115. Shin SH, Ponikau JU, Sherris DA, Congdon D, Frigas E, Homburger HA, Swanson MC, Gleich GJ,

Kita H. Chronic rhinosinusitis: an exaggerated immune response to ubiquitous airborne fungi. 12th International Congress of Immunology and 4th Annual Conference of FOCIS, July 18-23, 2004. Montreal, Quebec, Canada.

116. Rajagopala G, Iijima K, Kita H, David CS. Exposure to bacterial superantigen induces eosinophilic

airway inflammation and airway hyperreactivity in HLA class II transgenic mice. 12th International Congress of Immunology and 4th Annual Conference of FOCIS, July 18-23, 2004. Montreal, Quebec, Canada.

117. Radhakrishnan S, Iijima K, T Kobayashi, H Kita. M Rodriguez, LR Pease. Blockade of allergic

airway disease following systemic treatment with a B7-DC (PD-L2) crosslinking human antibody. 12th International Congress of Immunology and 4th Annual Conference of FOCIS, July 18-23, 2004. Montreal, Quebec, Canada.

118. Kobayashi T, Iijima K, H Kita. Beneficial effects of eosinophils in colitis induced by dextran sulfate

sodium. 12th International Congress of Immunology and 4th Annual Conference of FOCIS, July 18-23, 2004. Montreal, Quebec, Canada.

119. Yamazaki K, Volcheck GW, Kita H: Allergen-induced immune responses in non-allergic asthma.

The American Academy of Allergy and Immunology. 61st Annual Meeting. 2005 San Antonio, TX, USA.

120. Matesic D, Frigas E, Kita H, Harris PA, Volcheck GW, Markus PA, Weiler CR, Maddox DE, Li LTC,

Van Dellen RG, Hagan JB, Butterfield JH: Comparison of an in-house preparation of the major allergenic determinant of benzyl penicillin G with the commercially produced Pre-Pen. The American Academy of Allergy and Immunology. 61st Annual Meeting. 2005 San Antonio, TX, USA.

121. Matsuwaki Y, Inoue Y, Kita H: Fungal antigens from Alternaria stimulate activation and

degranulation of human eosinophils through a Gi-coupled PAF receptor. The American Academy of Allergy and Immunology. 61st Annual Meeting. 2005 San Antonio, TX, USA.

122. Volcheck GW, Harris PA, Kita H, Richardson DM, Davis MDP, Scroeter AL, Frigas E. Pilot study

of delayed hypersensitivity testing with fungal allergens in patients with allergic rhinitis and chronic

36

rhinosinusitis. The American Academy of Allergy and Immunology. 61st Annual Meeting. 2005 San Antonio, TX, USA.

123. Mehta V, Kobayashi T, Kita H: Effects of fungal antigen exposure on airway allergen sensitization.

The American Academy of Allergy and Immunology. 61st Annual Meeting. 2005 San Antonio, TX, USA.

124. Hagan JB, Kita H, Mehta: Sinus CT findings associated with sputum eosinophilia. International

Conference, American Thoracic Society. 2005. San Diego, CA, U.S.A. 125. White TA, Matsuwaki Y, Kita H: A role for ectoenzyme, CD38, in human eosinophil function. The

American Academy of Allergy Asthma and Immunology. 62nd Annual Meeting. 2006 Miami Beech, FL USA.

126. Molis WE, Kita H, Lee LA, Maki RJ, Smith R, Chang T, Weaver A, Pankratz V, Jacobson RM,

Poland GA, Juhn YJ: Timelines of diagnosis of asthma in children with associated factors. The American Academy of Allergy Asthma and Immunology. 62nd Annual Meeting. 2006 Miami Beech, FL USA.

127. Kobayashi T, Iijima K, Radhakrishman S, Mehta V, Vassallo R, Pease LR, Kita H: Innate immune

response to an environmental fungus, Alternaria, facilitates Th2-type airway sensitization to a bystander antigen. The American Academy of Allergy Asthma and Immunology. 62nd Annual Meeting. 2006 Miami Beech, FL USA.

128. Matsuwaki Y, Thomas W, Hotta K, Kita H: Exogeneous chitinase activate and induce

degranulation of human eosinophils through a protease-activated receptor-2 (PAR-2). The American Academy of Allergy Asthma and Immunology. 62nd Annual Meeting. 2006 Miami Beech, FL USA.

129. Frigas E, Markus PJ, Narr BJ, Danielson DR, Park PA, Bachman KA, Harris PA, O’Byrne MM,

Koos KE, Volcheck GW, Kita H, Shroeder DR. Allergy consultation and skin testing benefits significantly the selection of the antibiotic for antibacterial prophylaxis preoperative (ABPPO) in patients who report allergy to penicillin (PRAP). The American Academy of Allergy Asthma and Immunology. 62nd Annual Meeting. 2006 Miami Beech, FL USA.

130. Terada A, Kita H: Eosinophils produce an innate immune response to staphylococcus aureus

through recognition of peptidoglycan. The American Academy of Allergy Asthma and Immunology. 62nd Annual Meeting. 2006 Miami Beech, FL USA.

131. Frigas E, Park MA, Matesic D, Bachman KA, Volcheck GW, Gustafson RO, Friedman O, Pallanch

JF, Lane JI, Welker KM, Severson RJ, Butterfield JH, Hagan JB, Li JT, Schroeder DR, Kita H. A pilot, prospective, double blind, placebo-controlled treatment trial with Itraconazole orally in patients with chronic rhinosinusitis and asthma. The American Academy of Allergy Asthma and Immunology. 63rd Annual Meeting. 2007 San Diego, CA, USA.

132. Kung AY, Kita H, Guarderas JC, Gustafson RO, Park M. Oral itraconazole in the treatment of

chronic rhinosinusitis. The American Academy of Allergy Asthma and Immunology. 63rd Annual Meeting. 2007 San Diego, CA, USA.

37

133. Kobayashi T, Radhakrishnan S, Pease LR, Kita H. An environmental fungus, Alternaria, stimulate OX40L and CDR7 expression by dendritic cells. The American Academy of Allergy Asthma and Immunology. 63rd Annual Meeting. 2007 San Diego, CA, USA.

134. Matsuwaki Y, White T, Hotta K, Inoue Y, Lawrence CB, Kita H. Aspartate protease from Alternaria

induces cytokine production, and calcium signaling in human airway epithelial cells through a protease-activated receptor-2 (PAR-2). The American Academy of Allergy Asthma and Immunology. 63rd Annual Meeting. 2007 San Diego, CA, USA.

135. Wada K, Matsuwaki Y, Bingemann TA, Kita H. Cockroach activates and induces degranulation of

human eosinophils through protease-activated receptor-2 (PAR2). The American Academy of Allergy Asthma and Immunology. 63rd Annual Meeting. 2007 San Diego, CA, USA.

136. Dhillon RK, Kita H, Yawn BP, McGree ME, Weaver AL, Yoo KH, Wollan P, Boyce TG Jacobson

RM, Juhn YJ. Impact of asthma on the severity of invasive pneumococcal disease. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

137. Jung JA, Kita H, Yawn BP, McGree ME, Weaver AL, Yoo KH, Wollan P, Boyce TG, Jacobson RM,

Juhn YJ. Increased risk of invasive pneumococcal disease in atopic patients. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

138. Weiler CR, Squillace D, Kephart G, Romero Y, Alexander J, Kita H. Eosinophil degranulation,

gastric eosinophil-derived neurotoxin (gEDN) levels and dysphagis score in patients with eosinophilic esophagitis (EE). The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

139. Kephart G, Alexander J, Arora A, Romero Y, Smyrk T, Talley N, Kita H. Localization of eosinophil-

derived neurotoxin in esophageal tissues: A potential biomarker for eosinophilic esophagitis. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

140. Kato M, Ishioka T, Kita H, Hoshino H, Kozawa K, Kimura H. Major basic protein enhances GM-

CSF and IL-17 production, and apoptosis in bronchial epithelial cells, A549 infected with respiratory syncytial virus. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

141. Bartemes KR, Kita H. IL-25 induces type 2 immune responses by lineage-negative

undifferentiated cells. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

142. Cherry WB, Yoon J, Kita H. A novel IL-1 family cytokine, IL-33, activates and enhances survival

of human eosinophils. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

143. Kung AY, Kita H, Yawn BP, McGree ME, Weaver AL, Yoo KH, Wollan PH, Boyce TG, Jacobson

RM, Juhn YJ. The ecological relationship between the trends of asthma and invasive pneumococcal disease in Rochester, Minnesota. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

38

144. Dave SA, Yoon J, Wada K, Kobayashi T, Naseri M, Kita H. A mite antigen, Der P1, activates dendritic cells (DCs) and stimulates Th2 polarization through a toll-like receptor (TLR)-4 pathway. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

145. Kobayashi T, Iijima K, Kita H. An environmental fungus, Alternaria, Facilitates Th2-type airway

sensitization independently of TLR2 and TLR4. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

146. Iijima K, Kobayashi T, Bartemes KR, Kita H. Airway NK cells are involved in innate TH2-like

inflammation in response to an environmental antigen, Alternaria. The American Academy of Allergy Asthma and Immunology. 64th Annual Meeting. 2008, Philadelphia, PA, USA.

147. Hagan JB, Sykes AG, Kita H, Bartholmai BJ. Peripheral airway thickening in asthma is

associated with age, male gender, blood leukocyte and sputum eosinophilia. ATS 2008 International Conference, Toronto, Canada.

148. Kobayashi T, Iijima K, Checkel JL, Kita H. Eosinophils are not involved in the sensitization phase

of allergic responses. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

149. Matsuwaki Y, Lawrence CB, Kita H. An exogenous glycosidase, xylanase, induces human

eosinophil degranulation through protease-activated receptor-2 (PAR-2). The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

150. Yun HD, Jung JA, Kita H, Mann R, Tsigrelis C, Baddour LM, Jacobson RM, Boyce TG, Juhn YJ.

Atopic conditions and pneumococcal polysaccharide serotype-specific antibody levels. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

151. Karakelides M, Iijima K, Checkel JL, Kobayashi T, Kita H. Airway exposure to papain, a cysteine

protease, induces allergic inflammation. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

152. Rank MA, Kobayashi T, Bartemes KR, Kita H. Activation of dendritic cells by IL-33 initiates a Th-

2 response. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

153. Kouzaki H, O’Grady SM, Kita H. Airway epithelial cells recognize protease activities in allergens

and produce thymic stromal lymphopoietin (TSLP). The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

154. Jung JA, Kita H, Mann R, Tsigrelis C, Baddour LM, Jacobson RM, Boyce TG, Juhn YJ.

Assessment of the influence of asthma status on serotype-specific antibody response to pneumococcal polysaccharide antigens. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

155. Rigelman-Hedberg NE, Hettinger AS, Fink LR, Kita H, Jacobson R, Yawn B, Li X, Bailey K, Juhn

YJ. Assessment of susceptibility to pertussis in individuals with atopic conditions other than

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asthma. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

156. Yoo KH, Kita H, Jacobson RM, Yawn BP, Mcgree M, Weaver AL, Juhn YJ. Asthma status and

pneumococcal pneumonia: A population-based case-control study. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

157. Kobayashi T, Kita H. An endogenous danger signal, uric acid, attracts and activates human

eosinophils. The American Academy of Allergy Asthma and Immunology. 65th Annual Meeting. 2009, Washington, DC, USA.

158. Kouzaki H, Iijima K, Kobayashi T, O’Grady S, Kita H. Stressed airway epithelial cells release a

nuclear alarmin IL-33 and Trigger Th2-type immune responses. The American Academy of Allergy Asthma and Immunology. 66th Annual Meeting. 2010, New Orleans, LA, USA.

159. Kobayashi T, Iijima K, Checkel JL, Kita H. Airway exposure to IL-33 induces IL-5 dominant Th2-

type immune responses to inhaled antigens and asthma-like pathology. The American Academy of Allergy Asthma and Immunology. 66th Annual Meeting. 2010, New Orleans, LA, USA.

160. Kobayashi T, Uematsu K, Nagata M, Kita H. Autocrine release of ATP plays a pivotal role when

eosinophils degranulate in response to microbial stimuli. The American Academy of Allergy Asthma and Immunology. 66th Annual Meeting. 2010, New Orleans, LA, USA.

161. Gupta S, Kita H, Collins M, Perschy T, Heath A, Jurgensen C. Utility of eosinophil-derived

neurotoxin as a biomarker in eosinophilic esophagitis: results from a randomized, double-blind, controlled trial of Mepolizumab in pediatric patients. The American Academy of Allergy Asthma and Immunology. 66th Annual Meeting. 2010, New Orleans, LA, USA.

162. Hara K, Iijima K, Kobayashi T, Kephart G, Kita H. IL-33 mediates both innate and adaptive Th2-

type responses induced by proteases in the airway. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

163. Iijima K, Kobayashi T, Hara K, Kephart G, Kita H. Roles for IL-33 and TSLP in chronic

eosinophilic airway inflammation induced by airborne allergen exposure. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

164. Kato M, Ishioka T, Kita H, Kozawa K, Hayashi Y, Kimura H. Eosinophil granular proteins

specifically major basic protein damage bronchial epithelial cells infected with respiratory syncytial virus. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

165. Soma T, Kobayashi T, Seno S, Kita H. Extracellular release of endogenous ATP mediates

eosinophila recognition of fungal products and degranulation. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

166. Kita H. Epithelial cell-dendritic cell interactions in the airway mucosa. The American Academy of

Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

167. Kobayashi T, Iijima K, Kita H. Exposure to IL-1-family cytokines regulates differential development of antigen-specific Th2 cells and T follicular helper (Tfh) cells in the airway. The

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American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

168. Kouzaki H, Iijima K, Kobayashi T, O’Grady S, Kita H. Exposure to airborne allergens induces

rapid extracellular release of stored IL-1b from airway epithelial cells. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

169. Seno S, Iijima K, O’Grady S, Kita H. Cysteine proteases induce production and extracellular

release of IL-33 in airway epithelial cells. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

170. Kephart G, Kita H, Rank M, Katzka D. Can novel histologic biomarkers predict correct diagnosis

and treatment response in patients with matched esophageal eosinophilia. The American Academy of Allergy Asthma and Immunology. 68th Annual Meeting. 2012, Orlando, FL, USA.

171. Samant S, Rank MA, Hagan JB, Kita H. A proposed model to study immunologic changes during

chronic rhinosinusitis exacerbations: Data from a pilot study. The American Academy of Allergy Asthma and Immunology. 69th Annual Meeting. 2013, San Antonio, TX, USA.

172. Podjasek J, Jung JA, Kita H, Park MA, Juhn YJ. The role of the FACT score in predicting

antibody responses to pneumococcal antigens in asthmatics and non-asthmatics. The American Academy of Allergy Asthma and Immunology. 69th Annual Meeting. 2013, San Antonio, TX, USA.

173. Kouzaki H, Tojima I, Kita H, Shimizu T. Transcription of Interleukin-25 and extracellular release

of the protein is regulated by allergen proteases in airway epithelial cells. The American Academy of Allergy Asthma and Immunology. 69th Annual Meeting. 2013, San Antonio, TX, USA.

174. Divekar R, Hagan JB, Kita H. Phenotypic classification of allergen polysensitization in geriatric

adults. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

175. Iijima K, Kobayashi T, Hara, K Kephart G, Kita H. IL-33 and TSLP mediate chronic eosinophilic

airway inflammation and IgE antibody production induced by multiple airborne allergens. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

176. Hara K, Iijima K, Kobayashi T, Seno S, Tojima I, Kephart G, Ueno M, Maeno T, Kurabayashi M,

Kita H. Mucosal uric acid induces interleukin 33 and initiates Type 2 immune responses to inhaled protease allergens. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

177. Samant S, Rank M, Hagan J, O’Brien E, Lal D. Kita H. Immunologic changes during chronic

rhinosinusitis exacerbations compared to controls. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

178. Sun Y, Kita H. Alternaria-induced releases of IL-1 Alpha and IL-1 Beta from airway epithelial cells

through Syk and PKC signaling pathways. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

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179. Jin J, Alexander J, Kita H, Squillace D, Murray J, Arora A, Romero Y, Smyrk T, Weiler C. Mast cells, eosinophils and eosinophilic esophagitis. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

180. Kobayashi T, Iijima K, Kita H. Follicular helper T cells mediate IgE antibody production and

allergic immune responses in mice. The American Academy of Allergy Asthma and Immunology. 70th Annual Meeting. 2014, San Diego, CA, USA.

181. Anderson E, Kobayashi T, Iijima K, Kephart G, Bartemes K, Chen C, Kita, H. Crosstalk between

lungs and bone marrow during allergic inflammation. The American Association of Immunologists, Immunology 2014. Pittsburgh, PA, USA.

182. Bartemes K, Kita H. Group 2 innate lymphoid cells are present in mouse uterine tissue and may

play roles in healthy pregnancy. The American Association of Immunologists, Immunology 2014. Pittsburgh, PA, USA.

183. Uno K, Matsuwaki Y, Omura K, Hayashi E, Kita H, Otori N, Kojima H. The roles of Type 2 innate

lymphoid cells (ILC2) in chronic rhinosinusitis (CRS). The American Academy of Allergy, Asthma, and Immunology. 71st Annual Meeting. 2015, Houston, TX, USA.

184. Divekar R, O’Brien E, Jin J, Patel N, Rank M, Hagan J, Kita H. Symptom based clustering in

chronic rhinosinusitis reveals phenotypic heterogeneity. The American Academy of Allergy, Asthma, and Immunology. 71st Annual Meeting. 2015, Houston, TX, USA.

185. Podjasek J, Wi C, Kita H, Theel E, Juhn Y. Development and initial testing of whole blood cell

stimulation assay to determine Th1 vs Th2 immune profiles. The American Academy of Allergy, Asthma, and Immunology. 71st Annual Meeting. 2015, Houston, TX, USA.

186. Iijima K, Kobayashi T, Uchida M, Anderson E, Squillace D, Kephart G, O’Grady S, Kita H.

Oxidative stress responses to the fungal allergen alternaria mediate IL-33 secretion by airway epithelial cells and type 2 immunity in the airways. The American Academy of Allergy, Asthma, and Immunology. 72nd Annual Meeting. 2016, Los Angeles, CA, USA.

Formal Lectures at Regional Meetings

1. Kita H: Role of Cytokines in Eosinophil-Associated Lung Diseases. North Central Allergy Society. Update in Allergy and Immunology. 1995. Minneapolis, MN, USA.

2. Kita H: Mechanisms of eosinophilia. University of Minnesota CME Course. 2007. Minneapolis,

MN, USA. 3. Kita H: Advances in Mechanisms Underlying Chronic Eosinophilic Rhinosinusitis: Where are we

as of October 2007? 65th Meeting. Mayo Clinic Alumni Association. 2007. Rochester, MN, USA.

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13. VISITING PROFESSORSHIP

1. Visiting faculty member. Mie University School of Medicine, June 2, 1994, Tsu, Mie, Japan. I was invited to the University as a visiting faculty and gave a 90 minute seminar, entitled

“Eosinophils. From bedside to laboratory.” Graduate students and faculty members in clinical and basic science in the University attended the seminar.

2. Visiting faculty member. Department of Immunology and Microbiology, Rush-Presbyterian-St.

Lukes Medical Center, Chicago, IL, January 27, 1997. I gave a 1 hour lecture entitled, “Integrins as Versatile Signaling Molecules for Eosinophil

Activation”, to the faculty members and students of the medical center. 3. Visiting faculty member. Department of Medicine, Saitama Medical School. September 16, 1997,

Saitama, Japan. I gave a 90 minute lecture entitled, "Biology and Roles of Eosinophils in Diseases" to the

faculty members of the department and medical school students. 4. Visiting faculty member. Department of Pediatrics, Gunma University School of Medicine.

September 18, 1997, Gunma, Japan. I gave a 90 minute lecture entitled, "Mechanisms and Significance of Eosinophil Activation"

to the faculty members of the department and medical school students. 5. Visiting faculty member. Department of Bioregulatory Function, Tokyo University, Tokyo, Japan,

in July, 1999. I gave a 60 minute lecture entitled, "Molecular Mechanisms of Eosinophil Activation and

Degranulation" to the faculty members of the department, graduate students, and postdoctoral fellows.

6. Visiting faculty member. Mie University School of Medicine, Tsu, Mie, Japan, June 3, 2000. I was invited to the University as a visiting faculty and gave a 60 minute seminar, entitled

“Mechanisms of eosinophil activation and degranulation”. Graduate students and faculty members in clinical and basic science in the University attended the seminar.

7. Visiting faculty member. University of Wisconsin-Madison, Department of Medicine, Madison, WI,

June 9, 2000. I was invited by Dr. William Busse, Head, Allergy/Clinical Immunology, Professor of

Medicine, University of Wisconsin as a visiting faculty and gave a 60 minute seminar, entitled “Mechanisms of eosinophil degranulation in human diseases”. Graduate students and faculty members in clinical and basic science in the Division of Allergy and Clinical Immunology attended the seminar.

8. Visiting faculty member. Johns Hopkins University, Department of Immunology, Baltimore, MD,

February 14-15, 2001. I was invited by the Council of Immunology, Johns Hopkins University, as a visiting faculty

and gave a 60 minute seminar, entitled "Eosinophil activation and cell death: Two sides of the same coin". Graduate students and faculty members in clinical and basic science in the Department of Immunology and the Department of Medicine, Division of Allergy and Clinical Immunology, attended the seminar. I also visited with faculty members and fellows for one and a half day.

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9. Visiting faculty member. University of Buffalo, Buffalo, NY, August 29, 2002. I was invited to give a Medical Grand Rounds lecture, and gave a 60 minute presentation,

entitled “Asthma and Sinusitis: Are they hypersensitivity to common environmental fungi”. The audiences were clinicians, researches, postdocs and students.

10. Visiting faculty member. Northwestern University, Chicago, IL, May 2004. I was invited to give a lecture to the Allergy and Pulmonary divisions, and gave a 60 minute

presentation, entitled “Role of innate immunity to fungal antigens in asthma and chronic airway diseases”. The audiences were clinicians, researches, postdocs and students.

11. Visiting faculty member. University of Iowa, Iowa City, IA, January 2005. I was invited to give a lecture to the Pulmonary Division, and gave a 60 minute presentation,

entitled “Role of innate and acquired immunity fungi in asthma and sinusitis”. The audiences were clinicians, researches, postdocs and students.

12. Visiting faculty member. Emory University, GA, November 2007. I was invited to give a seminar to Immunology and Microbial Pathogenesis (IMP) Program,

and gave a 60 minute presentation, entitled “Role of Innate Immunity in Development and Exacerbation of Allergic Diseases”. The audiences were faculty members, postdocs, and students.

13. Visiting faculty member. Emory University, GA, September 2009. I was invited to give a seminar to Immunology and Microbial Pathogenesis (IMP) Program,

and gave a 60 minutes presentation, entitled “Epithelium and Immune Cell interaction in Th2-type immunity”. The audiences were faculty members, postdocs, and students.

14. Visiting faculty member. Northwestern University Feinberg School of Medicine, Chicago, IL, June

2010. I was invited to give a lecture entitled “Epithelium IL-33 in innate and adaptive Th2-type

airway immune responses”. The audiences were faculty members, fellows, researchers, and staff. 15. Visiting faculty member. Shiga University School of Medicine, Shiga, Japan, April, 2011 I was invited to give a lecture entitled “Role of airway mucosa in allergic inflammation”. The

audiences were faculty members, fellows, researchers, and staff. 16. Visiting faculty member. Mie University School of Medicine, Mie, Japan, April, 2011 I was invited to give a lecture entitled “Role of airway mucosa in allergic inflammation”. The

audiences were faculty members, fellows, researchers, and staff. 17. Visiting faculty member. Mie National Hospital, Mie, Japan, May, 2012 I was invited to give a lecture entitled “Immunological mechanisms of asthma and allergic

diseases”. The audiences were faculty members, fellows, researchers, and staff. 18 Visiting faculty member. Gunma Children’s Hospital, Gunma, Japan, June, 2012 I was invited to give a lecture entitled “Immunological mechanisms of asthma and allergic

diseases”. The audiences were faculty members, fellows, researchers, and staff. 19. Visiting faculty member. Virginia Bioinformatics Institute (Virginia Tech), Blacksburg, VA, Oct,

2012 I was invited to give a lecture entitled “Microbe interactions in asthma and allergic diseases”.

The audiences were faculty members, fellows, researchers, and staff.

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20. Visiting faculty member. Tohoku Pharmaceutical University, Sendai, Miyagi, Japan, July, 2013 I was invited to give a lecture entitled “Evolution of the immunological mechanisms of

asthma”. The audiences were faculty members, fellows, researchers, and staff. 21. Visiting faculty member. Department of Chemistry and Biochemistry. North Dakota State

University, Fargo, ND. Nov 2013. I was invited to give a lecture entitled “Initiation of type 2 immunity and asthma by non-

traditionall immune cells.” The audiences were faculty members, fellows, and students. 22. Visiting faculty member. Department of Pediatrics, Indiana University School of Medicine,

Indianapolis, IN, Nov 2013. I was invited to give a lecture entitled “Reguation of type 2 immunity and asthma by non-

conventional immune cells. The audiences were faculty members, fellows, and students. 23. Visiting faculty member. Mie University Graduate School of Medicine, Mie, Japan, April 2014. I was invited to give a lecture entitled “Recent conceptual advances in immunological

mechanisms of allergic diseases”. The audiences were faculty members, fellows, researchers, and staff.

24. Visiting faculty member, Department of Medicine, Washington University School of Medicine, St.

Louis, MO, May 2014. I was invited to give a lecture entitled “Regulation of type 2 immunity and asthma by non-

conventional immune cells”. The audiences were faculty members, fellows, researchers, and staff. 25. Visiting faculty member, Department of Otorhinolaryngology, Northwestern University School of

Medicine, Chicago, IL, August 2014. I was invited to give a lecture entitled “Immunological mechanisms and experimental models

of chronic allergic airway inflammation in asthma and rhinosinusitis”. The audiences were faculty members, fellows, researchers, and staff.

26. Visiting faculty member, Division of Allergy/Immunology and Departmement of Medicine,

Northwestern University School of Medicine, Chicago, IL, August 2014. I was invited to give a lecture entitled “Three lymphocyte subsets in Th2-type immune

responses”. The audiences were faculty members, fellows, researchers, and staff. 27. Visiting faculty member, Timothy A. Johnson Medical Scholar Lecture Series, Virginia Tech

Carilion School of Medicine, Roanoke, VA, October 2014. I was invited to give a lecture entitled “Immunological Mechanisms of Allergic Diseases and

Asthma”. The audiences were medical students, graduate students, and faculty members. 28. Visiting faculty member, Department of Biomolecular Science, Saga Medical School, Saga, Japan,

June 2016. I was invited to give a lecture entitled “Excitiment and impotance of biomedical research”.

The audiences were faculty members, fellows, researchers, and staff. 29. Visiting faculty member, Department of Pediacrics, Tokai University School of Medicine,

Kanagawa, Japan, June 2016.

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I was invited to give a lecture entitled “Roles of innate immunity in development and persistence of allergic diseases”. The audiences were faculty members, fellows, researchers, and staff.

30. Visiting faculty member, Grant Rounds Speaker, Le Bonheur Children’s Hospital, University of

Tennessee Health Science Center, Memphis, TN, July 2016. I was invited to give a lecture entitled “Innate and adaptive Immune Response in Allergic

Diseases”. The audiences were faculty members, physicians, fellows, researchers, and staff.

14. CLINICAL PRACTICE, INTERESTS, AND ACCOMPLISHMENTS Participated in the development of the Sputum Inflammatory Parameter (SIP) test for diagnosis of patients with chronic cough and bronchial asthma.

15. RESEARCH INTERESTS A number of recent studies indicate that inflammatory processes play important roles in the

pathophysiology of allergic diseases, such bronchial asthma, hay fever, atopic dermatitis, and chronic rhinosinusitis. The overall goals of my laboratory are to better understand the pathophysiologic mechanisms of these diseases with specific focus on immune cells and eosinophilic leukocytes and to find ways to prevent, to treat and to cure these diseases. Five specific goals have been identified as follows:

1) To study the mechanisms involved in early development of Th2-type immune responses to allergens.

We have been studying how airway exposure to common allergens leads to development of Th2-type immunity. We have examined how products of airway epithelial cells affect functions of dendritic cells (DCs), CD4+ T cells, and other immune cells resident in the airways. Several animal models have also been created to dissect the immunological mechanisms involved in development of Th2-type airway immune response.

2) To study the mechanisms of chronic activation of immune cells in patients with allergic disorders, such as asthma and chronic sinusitis. We have been studying the responses of immune cells, such as lymphocytes, NK cells and dendritic cells (DCs), to common environmental antigens in patients with these disorders. Animal models have also been developed to mimic exacerbation of chronic airway inflammation and to manipulate the immune system as a potential therapeutic approach for patients.

3) To study the pathologic mechanisms of eosinophils in human diseases. We have been studying how eosinophils infiltrate into the tissues, how eosinophils are activated in local inflammatory sites, and what roles eosinophils play in immunity, tissue homeostasis, and pathology of human diseases.

4) To study the regulatory and molecular mechanisms of eosinophil activation. By using various in vitro models, we have been identifying and investigating the potent stimuli involved in eosinophil activation and how eosinophil function is regulated by various cell surface receptors and adhesion molecules, their ligands, and intracellular signaling pathways. Several animal models are used to evaluate the physiologic significance of these in vitro observations.

5) To study the novel treatment approaches for patients with allergic disorders. We have been studying whether manipulation of mucosal environment by anti-fungal agents and whether manipulation of DC functions by novel crosslinking antibody would prevent development of or inhibit progression of airway inflammation in mouse models of diseases and in patients with allergic disorders.

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16. RESEARCH GRANTS AWARDED

Active Grants 1. R01 AI71106-09 (P.I. Kita) 5/20/13 - 4/30/18 2.40 calendar months NIH/NIAID $266,800 (annual direct cost) Alternaria and protease in innate and adaptive Th2 immunity 2. R01 HL117823-4 (P.I. Kita) 1/15/14-12/31/17 2.40 calendar months NIH/NHLBI $225,000 (annual direct cost) Type 2 innate lymphoid cells and asthma 3. R01 AI128729-1 (Kita, O’Grady, MPI) 12/1/16-11/30/21 1.80 calendar months

NIH/NIAID $326,922 (annual direct cost) Mechanisms of IL-33 secretion in allergic diseases

4. MNP #16.48 (Kita, Jameson, MPI) 1/15/17-1/15/19 1.20 calendar months Minnesota Partnership for Biotechnology $996,803 (total) Testing susceptibility of “dirty” mice to induction of asthmatic disease and lung pathology 5. T32 AI07047-34 (Director; Kita) 8/01/12 - 7/31/17 0 calendar months NIH/NIAID $161,226 (annual direct cost) Training Grant in Allergic Diseases 6. R01 HL88029-06 (P.I. Prakash, Co-I. Kita) 9/1/13 - 8/31/18 0.6 calendar

months NIH/NHLBI $250,000 (annual direct cost) Neutrophins in the Lungs 7. R01 HL126667-1 (P.I. Juhn, Co-I. Kita) 4/1/15-3/31/18 0.36 calendar months NHLBI/NIH $250,000 (annual direct cost) Asthma ascertainment and characterization through electronic health records

Pending Grants None.

Completed NIH Grants During Past 3 Years 1. R56 AI49235-11 (P.I. Kita) 7/6/12-6/30/14 (NCE) 1.2 calendar months NIH/NIAID $181,277 (direct cost) The Pathogenesis of Chronic Rhinosinusitis

2. R56 AI 34486-17 (P.I. Kita) 9/1/12-8/31/14 (NCE) 2.4 calendar months

NIH/NIAID $250,000 (direct cost) Mechanisms of Eosinophilic Inflammation in Human Disease

3. Koltan Pharmaceuticals (Kita, Luccinettei, Co-PI) 1/1/14-12/31/14 0.30 calendar months Koltan Pharmaceuticals $63,281 Therapeutic targeting of mast cells in chronic inflammatory autoimmune diseases

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4. Guthy Jackson-2 (P.I. Lucchinetti, Co-I. Kita) 6/1/10-5/31/13 0.60 calendar months Guthy Jackson Charitable Foundation $253,846 (annual direct cost) Synergistic interactions between astrocytes, eosinophils and AGP4-IgG in NMO 5. Clinical Innovator-2 (P.I. Vassallo, Co-I. Kita) 7/1/10-6/30/13 0.24 calendar months Flight Attendant Medical Research Institute $99,904 Adjuvant effects of oxidative cigarette smoke constituents 6. R01 AI 34486-16 (P.I. Kita) 8/1/06 - 7/31/12 1.08 calendar months NIH/NIAID Mechanisms of Eosinophil Degranulation in Human Disease 7. R01 HL110539-4 (M.P.I. Kita) 8/1/11-10/31/15 1.56 calendar months

NIH/NHLBI $343,690 (annual direct cost) Allergen-induced IL-33 release by the airway epithelium

17. ISSUED PATENTS 1. US 6,416,955, July 9, 2002, Eosinophil Degranulating Conditions 2. US 7,501,119, March 10, 2009, Methods and molecules for modulating an immune response 3. US 7,659,080, February 9, 2010, Detecting a bacterial process in chronic rhinosinusitis 4. US 7,662,400, February 16, 2010, Fungus-induced inflammation and eosinophil degranulation 5. US 7,887,820, February 15, 2011, Fungus-induced inflammation and eosinophil degranulation 6. US 8,263,576, September 11, 2012, Non-natural sphingolipid analogs and uses thereof 7. Europe, 1,768, 999, June 19, 2013, B7-DC binding antibody 18. BIBLIOGRAPHY

(An asterisk indicates that the primary author is a trainee for whom Dr. Kita served as mentor)

Full Length, Peer-Reviewed, Original Articles

1. Yoshida K, Kitabatake M, Komada M, Kita H: Detection and recording by personal computer of late asthmatic response of guinea pigs. Arerugi-Jpn. J Allergol. 36:865-869, 1987.

2. Komada Y, Kita H, Ochiai H, Azuma E, Kamiya H, Sakurai M: Immunoregulatory abnormalities in

Kawasaki syndrome. Mie Medical J. 37:291-295, 1987. 3. Fujisawa T, Abu-Ghazaleh R, Kita H, Sanderson CJ, Gleich GJ: Regulatory effect of cytokines

on eosinophil degranulation. J Immunol. 144:642-646, 1990. 4. Kita H, Abu-Ghazaleh R, Sanderson CJ, Gleich GJ: Effect of steroids on immunoglobulin-

induced eosinophil degranulation. J Allergy Clin Immunol. 87:70-77, 1991. 5. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT: Regulation of Ig-induced eosinophil

degranulation by adenosine 3´,5´-cyclic monophosphate. J Immunol. 146:2712-18, 1991.

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6. Kita H, Ohnishi T, Okubo Y, Weiler D, Abrams JS, Gleich GJ: Granulocyte/macrophage colony-stimulating factor and interleukin-3 release from human peripheral blood eosinophils and neutrophils. J Exp Med. 174:745-748, 1991.

7. Sedgwick JB, Calhoun WJ, Gleich GJ, Kita H, Abrams JS, Schwartz LB, Volovitz B, Ben-Yaakov

M, Busse WW: Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. Am Rev Respir Dis. 144:1274-1281, 1991.

8. van Haelst Pisani C, Kovach JS, Kita H, Leiferman KM, Gleich GJ, Silver JE, Dennin R, Abrams

JS: Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer. Blood 78:1538-1544, 1991.

9. Ten RM, Butterfield JH, Kita H, Weiler DA, Fischkoff S, Ishizaka T, Sanderson CJ, Gleich GJ:

Eosinophil differentiation of human umbilical cord mononuclear cells and prolonged survival of mature eosinophils by murine EL-4 thymoma cell conditioned media. Cytokine 3:350-359, 1991.

10. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT: Role of pertussis toxin-sensitive G proteins in

stimulus-dependent human eosinophil degranulation. J Immunol. 147:3466-3473, 1991. *11. Wallen N, Kita H, Weiler D, Gleich GJ: Glucocorticoids inhibit cytokine-mediated eosinophil

survival. J Immunol. 147:3490-3495, 1991. 12. Kita H, Weiler DA, Abu-Ghazaleh R, Sanderson CJ, Gleich GJ: Release of granule proteins from

eosinophils cultured with IL-5. J Immunol. 149:629-635, 1992. 13. Huftel MA, Swenson CA, Borcherding WR, Dick EC, Hong R, Kita H, Gleich GJ, Busse WW: The

effect of T-cell depletion on enhanced basophil histamine release after in vitro incubation with live influenza A virus. Am J Respir Cell Mol Biol. 7:434-440, 1992.

14. Abu-Ghazaleh RI, Dunnette SL, Loegering DA, Checkel JL, Kita H, Thomas LL, Gleich GJ:

Eosinophil granule proteins in peripheral blood granulocytes. J Leukocyte Biol. 52:611-618, 1992. 15. Abu-Ghazaleh RI, Kita H, Gleich GJ. Eosinophil activation and function in health and disease.

Immunol. Ser. 57:137-167, 1992. *16. Ohnishi T, Kita H, Weiler D, Sur S, Sedgwick JB, Calhoun WJ, Busse WW, Abrams JS, Gleich

GJ: IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late phase reaction. Am Rev Respir Dis. 147:901-907, 1993.

*17. Ide M, Weiler D, Kita H, Gleich GJ: Ammonium chloride exposure inhibits cytokine-mediated

eosinophil survival. J Immunol Methods 168:187-96, 1994. *18. Horie S, Kita H: CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils

induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor. J Immunol. 152:5457-5467, 1994.

19. Kita H, Kato M, Gleich GJ, Abraham RT. Tyrosine phosphorylation and inositol phosphate

production: are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? J Allergy Clin Immunol. 94:1272-1281, 1994.

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20. Kita H, Abu-Ghazaleh RI, Sur S, Gleich GJ: Eosinophil major basic protein induces degranulation

and IL-8 production by human eosinophils. J Immunol. 154:4749-4758, 1995. 21. Kita H, Mayeno AN, Weyand CM, Goronzy JJ, Weiler DA, Lundy SK, Abrams JS, Gleich GJ:

Eosinophil-active cytokine from mononuclear cells cultured with L-tryptophan products: An unexpected consequence of endotoxin contamination. J Allergy Clin Immunol. 95:1261-1267, 1995.

*22. Kaneko M, Swanson MC, Gleich GJ, Kita H: Allergen-specific IgG1 and IgG3 through FcγRII

induce eosinophil degranulation. J Clin Invest. 95:2813-2821, 1995. *23. Kato M, Abraham RT, Kita H: Tyrosine phosphorylation is required for eosinophil degranulation

induced by immobilized immunoglobulins. J Immunol. 155:357-366, 1995. 24. Sosman JA, Bartemes K, Offord KP, Kita H, Fisher SG, Kefer C, Ellis TA, Fisher RI, Higgins TJ,

Gleich GJ: Evidence for eosinophil activation in cancer patients receiving recombinant interleukin-4: Effects of interleukin-4 alone and following interleukin-2 administration. Clin Cancer Res. 1:805-812, 1995.

*25. Kaneko M, Horie S, Kato M, Gleich GJ, Kita H: A crucial role for β2 integrin in the activation of

eosinophils stimulated by IgG. J Immunol. 155:2631-2641, 1995. 26. Nagata M, Sedgwick JB, Bates ME, Kita H, Busse WW: Eosinophil adhesion to vascular cell

adhesion molecule-1 activates superoxide anion generation. J Immunol. 155:2194-2202, 1995. 27. Kita H, Horie S, Gleich GJ: Extracellular matrix proteins attenuate activation and degranulation of

stimulated eosinophils. J Immunol. 156:1174-1181, 1996. 28. Kita H, Sur S, Hunt LW, Edell ES, Weiler DA, Swanson MC, Samsel RW, Abrams JS, Gleich GJ:

Cytokine production at the site of disease in chronic eosinophilic pneumonitis. Am J Respir Crit Care Med. 153:1437-1441, 1996.

29. Sur S, Kita H, Gleich GJ, Chenier TC, Hunt LW: Eosinophil recruitment is associated with IL-5,

but not with RANTES, 24-hours after allergen challenge. J Allergy Clin Immunol. 97:1272-1278, 1996.

*30. Hagan JB, Bartemes KR, Kita H, Ottesen EA, Awadzi K, Nutman TB, Gleich GJ: Elevations in

granulocyte-macrophage colony-stimulating factor and interleukin-5 levels precede posttreatment eosinophilia in onchocerciasis. J Infect Dis. 173:1277-1280, 1996.

*31. Ohnishi T, Kita H, Mayeno AN, Okada S, Sur S, Broide DH, Gleich GJ: Lidocaine in

bronchoalveolar lavage fluid (BALF) is an inhibitor of eosinophil-active cytokines. Clin Exp Immunol. 104:325-331, 1996.

*32. Nakajima H, Gleich GJ, Kita H: Constitutive production of IL-4 and IL-10 and stimulated

production of IL-8 by normal peripheral blood eosinophils. J Immunol. 156:4859-4866, 1996. *33. Horie S, Gleich GJ, Kita H: Cytokines directly induce degranulation and superoxide production

from human eosinophils. J Allergy Clin Immunol. 98:371-381, 1996.

50

34. Weiler CR, Kita H, Hukee M, Gleich GJ: Eosinophil viability during immunoglobulin-induced

degranulation. J Leukocyte Biol. 60:493-501, 1996. 35. Martin LB, Kita H, Leiferman KM, Gleich GJ. Eosinophils in allergy: role in disease, degranulation,

and cytokines. Int Arch Allergy Immunol. 109:207-215, 1996. *36. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM: Transmigration of eosinophils through

basement membrane components in vitro: Synergistic effects of platelet-activating factor and eosinophil-active cytokines. Am J Respir Cell Mol. Biol. 16:455-463, 1997.

*37. Kim J, Gleich GJ, Kita H: Roles of CD9 molecules in survival and activation of human eosinophils.

J Immunol. 159:926-933, 1997. *38. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM: Migration of eosinophils through

basement membrane components in vitro: Role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol. 17:519-528, 1997.

*39. Kato M, Kita H, Morikawa A: Role of tyrosine kinasesin human eosinophil degranulation. Int Arch

Allergy Immunol. 114(Suppl 1):14-17, 1997. *40. Nakajima H, Gleich GJ, Fukuda T, Makino S, Kita H: Production of IL-8 and release of

eosinophil-derived neurotoxin by normal peripheral blood eosinophils. Int Arch Allergy Immunol. 114(Suppl 1):36-39, 1997.

41. Ohashi H, Ishikawa M, Ito J, Ueno A, Gleich GJ, Kita H, Kawai H, Fukamachi H: Sulochrin

inhibits eosinophil degranulation. J Antibiotics. 50:972-974, 1997. *42. Okada S, Hagan JB, Kato M, Bankers-Fulbright JL, Hunt LW, Gleich GJ, Kita H: Lidocaine and

its analogues inhibit IL-5-mediated survival and activation of human eosinophils. J Immunol. 160:4010-4017, 1998.

*43. Kato M, Abraham RT, Okada S, Kita H: Ligation of the β2 integrin triggers activation and

degranulation of human eosinophils. Am J Respir Cell Mol Biol. 18:675-686, 1998. 44. Bankers-Fulbright JL, Kephart GM, Loegering DA, Bradford AL, Okada S, Kita H, Gleich GJ:

Sulfonylureas inhibit cytokine-induced eosinophil survival and activation. J Immunol. 160:5546-5553, 1998.

*45. Levy AM, Kita H, Philips SF, Schkade PA, Dyer PD, Gleich GJ, Dubravec VA: Eosinophilia and

gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol. 101:613-620, 1998.

46. Sur S, Glitz DG, Kita H, Kujawa SM, Peterson EA, Weiler DA, Kephart GM, Wagner JM, George

TJ, Gleich GJ, Leiferman KM: Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes. J Leukocyte Biol. 63:715-722, 1998.

47. Nagata M, Sedgwick JB, Kita H, Busse WW: Granulocyte macrophage colony-stimulating factor

augments ICAM-1 and VCAM-1 activation of eosinophil function. Am J Respir Cell Mol Biol. 19:158-166, 1998.

51

*48. Hagan JB, Kita H, Gleich GJ: Inhibition of interleukin-5 mediated eosinophil viability by

fluticasone 17-propionate: comparison with other glucocorticoids. Clin Exp Allergy 28:999-1006, 1998.

*49. Motegi Y, Kita H: Interaction with secretory component stimulates effector functions of human

eosinophils but not of neutrophils. J Immunol. 161:4340-4346, 1998. 50. Ohashi H, Motegi Y, Kita H, Gleich GJ, Miura T, Ishikawa M, Kawai H, Fukamachi H: Sulochrin

inhibits eosinophil degranulation and chemotaxis. Inflammation Res. 47:409-415, 1998. *51. Kato M, Kita H, Tokuyama K, Morikawa A: Signal transduction in activation of human

eosinophils: G protein-dependent and -independent pathways. Int Arch Allergy Immunol. 117(Suppl. 1):63-67, 1998.

*52. Kato M, Kita H, Tokuyama K, Morikawa A: Cross-linking of the β2 integrin, CD11b/CD18, on

human eosinophils induces protein tyrosine phosphorylation and cellular degranulation. Int Arch Allergy Immunol. 117(Suppl. 1):68-71, 1998.

53. Kita H, Gleich GJ. Roles of eosinophils and neutrophils in fatal asthma. Lung Biol Health Dis.

115:157-173, 1998. 54. Ohashi H, Takei M, Ide Y, Ishii Y, Kita H, Gleich GJ, Ishikawa M, Fukamachi H: Effect of

interleukin-3, interleukin-5, and hyaluronic acid on cultured eosinophils derived from human umbilical cord blood mononuclear cells. Int Arch Allergy Immunol. 118:44-50, 1999.

*55. Bartemes K, McKinney S, Gleich GJ, Kita H: Endogenous platelet-activating factor is critically

involved in effector functions of eosinophils stimulated with IL-5 or IgG. J Immunol. 162:2982-2989, 1999.

*56. Kim J-T, Kita H: Ligation of FcγRII (CD32) pivotally regulates survival of human eosinophils. J

Immunol. 162:4253-4259, 1999. 57. Kita H, Kaneko M, Bartemes K, Weiler D, Schimming A, Reed CE, Gleich GH: Does IgE bind to

and activate eosinophils from patients with allergy? J Immunol. 162:6901-6911, 1999. 58. Yamazaki K, Suzuki K, Nakamura A, Sato S, Lindor KD, Batts KP, Tarara JE, Kephart GM, Kita H,

Gleich GJ: Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrohsis. Hepatology 30:71-78, 1999.

*59. Nakajima H, Loegering DA, Kita H, Kephart GM, Gleich GJ: Reactivity of monoclonal antibodies

EG1 and EG2 with eosinophils and their granule proteins. J Leukocyte Biol. 66:447-454, 1999. *60. Kato M, Kimura H, Tachibana A, Motegi Y, Tokuyama K, Kita H, Morikawa A: Intracellular

signaling pathways in human eosinophil activation: Role of beta2 integrin, alphaMbeta2. Int Arch Allergy Immunol. 120 (Suppl 1):51-53, 1999.

61. Sanico AM, Kita H, Leiferman KM, Saini SS: Eosinophilia in a 23-year-old woman with asthma.

Ann Allergy Asthma Immunol. 83:193-199, 1999.

52

62. Kaneko M, Schimming A, Gleich GJ, Kita H: Ligation of IgE receptor(s) causes an anaphylactic response and neutrophil infiltration, but does not induce eosinophilic inflammation in mice. J Allergy Clin Immunol. 105:1202-1210, 2000.

63. Motegi Y, Kita H, Kato M, Morikawa A: Role of secretory IgA, secretory component, and

eosinophils in mucosal inflammation. Int Arch Allergy Immunol. 122(Suppl 1):25-27, 2000. *64. Kato M, Kita H, Kimura H, Tachibana A, Motegi Y, Tokuyama K, Morikawa A: Stimulation of the

β2 integrin, αMβ2, triggers tyrosine phosphorylation and cellular degranulation on human eosinophils. Int Arch Allergy Immunol. 122(Suppl 1):33-35, 2000.

65. Kita H, Jorgensen RK, Reed CE, Dunnette SL, Swanson MC, Bartemes KR, Squillace D,

Blomgren J, Bachman K, Gleich GJ: Mechanism of topical glucocorticoid treatment of hay fever: IL-5 and eosinophil activation during natural allergen exposure are suppressed, but IL-4, IL-6, and IgE antibody production are unaffected. J Allergy Clin Immunol. 106:521-529, 2000.

66. Ohashi H, Takei M, Kita H, Gleich GJ, Fukamachi H: β2 integrin-dependent tyrosine

phosphorylation of PYK-2 in PAF-activated eosinophils. Allergol Int. 49:245-252, 2000. 67. Liu LY, Swensen CA, Kelly EAB, Kita H, Busse WW: The relationship of sputum eosinophilia and

sputum cell generation of IL-5. J Allergy Clin Immunol. 106:1063-1069, 2000. 68. Shin MH, Kita H, Park HY, Seoh JY: Cysteine protease by Paragonismus wetermani attenuates

effector functions of human eosinophils stimulated with immunoglobulin G. Infect Immun. 69:1599-1604, 2001. PMCID:PMC98062.

*69. Yamazaki K, Gleich GJ, Kita H: Bile acids induce eosinophil degranulation via two different

mechanisms. Hepatology 33:582-590, 2001. 70. Moertel CL, Kazacos KR, Butterfield JH, Kita H, Watterson J, Gleich GJ: Eosinophil-associated

inflammation and elaboration of eosinophil-derived proteins in two children with raccoon roundworm (Bayliascaris procyonis) encephalitis. Pediatrics 108(5):NIL_98-NIL_104, 2001.

71. Bankers-Fulbright J, Kita H, Gleich GJ, O'Grady SM: Regulation of human eosinophil NADPH

oxidase activity: A central role for PKCdelta. J Cell Physiol. 189:306-315, 2001. *72. Miike S, McWilliam AS, Kita H: Trypsin induces activation and inflammatory mediator release

from human eosinophils through proteinase-activated receptor-2. J Immunol. 167:6615-6622, 2001.

*73. Kobayashi H, Gleich GJ, Butterfield JH, Kita H: Human eosinophils produce neutrophins and

secrete nerve growth factor on immunologic stimuli. Blood 99:2214-2220, 2002. 74. Matsumoto R, Hirashima M, Kita H, Gleich GJ: Biological activities of ecalectin: A novel

eosinophil-activating factor. J Immunol. 168:1961-1967, 2002. 75. Hunt LW, Gleich GJ, Kita H, Weiler DA, Schroeder DR, Vuk-Pavlovic Z, Sur S: Removal of

bronchoalveolar cells augments the late eosinophilic response to segmental allergen challenge. Cli Exp Allergy 32:210-216, 2002.

53

76. Liu LY, Coe CL, Swenson CA, Kelly EA, Kita H, Busse WW: School examinations enhance airway inflammation to antigen challenge. Am J Respir Crit Care Med. 165:1062-1067, 2002.

*77. Kato M, Kimura H, Motegi Y, Tachibana A, Minakami H, Morikawa A, Kita H: Platelet-activating

factor activated two distinct effector pathways in human eosinophils. J Immunol. 169:5252-5259, 2002.

78. Taylor MJ, Ponikau JU, Sherris DA, Gleich GJ, Kita H, Kern EB: Detection of fungal organisms in

eosinophilic mucin using a fluorescein labeled chitin-specific binding protein. J Otorhinolaryngol Head Neck Surg. 127:377-383, 2002.

79. Liu LY, Sedgwick JB, Bates ME, Vrtis RF, Gern JE, Kita H, Jarjour NN, Busse WW, Kelly EAB:

Decreased expression of membrane IL-5Rα on human eosinophils: I. Loss of membrane IL-5Rα on airway eosinophils and increased soluble IL-5Rα in the airway after allergen challenge. J Immunol. 169:6452-6458, 2002.

80. Liu LY, Sedgwick JB, Bates ME, Vrtis RF, Gern JE, Kita H, Jarjour NN, Busse WW, Kelly EAB:

Decreased expression of membrane IL-5Rα on human eosinophils: II. IL-5 down-modulates its receptor via a protease-mediated process. J Immunol. 169:6459-6466, 2002.

*81. Wei JL, Kita H, Sherris DA, Kern EB, Weaver A, Ponikau JU: The chemotactic behavior of

eosinophils in patients with chronic rhinosinusitis. Laryngoscope 113:303-306, 2003. 82. Ponikau JU, Sherris DA, Kita H, Kern EB: Intranasal antifungal treatment in 51 patients with

chronic rhinosinusitis (CRS). J Allergy Clin Immunol. 110:862-866, 2002. *83. Miike S, Kita H: Human eosinophils are activated by cysteine proteases and release

inflammatory mediators. J Allergy Clin Immunol. 111:704-713, 2003. 84. Liu LY, Swenson CA, Kelly EA, Kita H, Jarjour NN, Busse WW: Comparison of the effects of

repetitive low-dose and single-dose antigen challenge on airway inflammation. J Allergy Clin Immunol. 111:818-825, 2003.

85. Bankers-Fulbright JL, Gleich GJ, Kephart GM, Kita H, O’Grady SM: Regulation of eosinophil

membrane depolarization during NADPH oxidase activation. J Cell Sci. 116:3221-3226, 2003. *86. Kobayashi T, Iijima K, Kita H: Marked airway eosinophilia prevents development of airway

hyperresponsiveness during an allergic response in IL-5 transgenic mice. J Immunol. 170:5756-5763, 2003.

*87. Shin S-H, Lee S-H, Jeong H-S, Kita H: The effect of nasal polyp epithelial cells to the activation

of eosinophils. Laryngoscope. 113:1374-1377, 2003. 88. Murphy JG, Wright RS, Bruce GK, Baddour LM, Farrel MA, Edwards WD, Kita H, Cooper LT:

Eosinophilic-lymphocytic myocarditis following immunization for smallpox in a previously health 29-year-old man. Lancet. 362:1378-1380, 2003.

89. Sedgwick JB, Hwang YS, Gerbyshak-Szudy HA, Jansen KJ, Menon I, Kita H, Busse WW:

Oxidized low density lipoprotein activates migration and degranulation of human peripheral neutrophils and eosinophils. Am J Respir Cell Moll Biol. 29:702-709, 2003.

54

90. Ponikau JU, Sherris DA, Kephart GM, Kern EB, Gaffey TA, Tarara JE, Kita H: Features of airway

remodeling and eosinophilic inflammation in chronic rhinosinusitis: Is histopathology similar to asthma. J Allergy Clin Immunol. 112:877-882, 2003.

*91. Shin M-H, Seoh JY, Park HY, Kita H: Excretory-secretory products secreted by Paragonisms

westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF. Int Arch Allergy Immunol. 132:48-57, 2003.

92. Hunt LW, Frigas E, Butterfield JH, Kita H, Blomgren J, Dunnette SL, Offord KP, Gleich GJ:

Treatment of asthma with nebulized lidocaine: A randomized, placebo-controlled study. J Allergy Clin Immunol. 113:853-859, 2004.

93. Sivanandam AS. Mohan S. Kapur S. Kita H. Lau KHW. Bagi G. Baylink DJ. Qin XZ. Covalent

interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A. Arch Biochem Biophysics. 423:343-350, 2004.

94. Sivanandam AS. Mohan S. Kita H. Kapur S. Chen ST. Linkhart TA. Bagi G. Baylink DJ. Qin XZ.

Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester. Biochemical J. 379:57-64, 2004. PMCID:PMC1224057.

*95. Kato M, Kita H, Tachibana A, Hayashi Y, Tsuchida Y, Kimura H: Dual signaling and effector

pathways mediate human eosinophil activation by platelet-activating factor. Int Arch Allergy Immunol. 134 (Suppl 1): 37-43, 2004.

96. Radharkrishnan S, Iijima K, Kobayashi T, Rodriguez M, Kita H, Pease LR: Blockade of allergic

airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody. J Immunol. 173:1360-1365, 2004.

*97. Shin S-H, Ponikau JU, Sherris DA, Congdon D, Frigas E, Homburger HA, Swanson MC, Gleich

GJ, Kita H: Chronic rhinosinusitis: An enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 114:568-574, 2004.

98. Sedgwick JB, Vrtis RF, Jansen KJ, Kita H, Bartemes K, Busse WW: Peripheral blood eosinophils

from patients with allergic asthma contain increased intracellular eosinophil derived neurotoxin. J Allergy Clin Immunol. 114:568-574, 2004.

99. Davis LJ, Kita H. Pathogenesis of chronic rhinosinusitis: role of airborne fungi and bacteria.

Immunol Allergy Clin. North Am. 24:59-73, 2004. 100. Reed CE, Kita H. The role of protease activation of inflammation in allergic respiratory diseases.

J Allergy Clin Immunol. 114:997-1008, 2004. 101. Bankers-Fulbright JL, Kephart GM, Bartemes KR, Kita H, O’Grady SM. Platelet-activating factor

stimulates cytoplasmic alkalinization and granule acidification in human eosinophils. J Cell Science. 117:5749-5757, 2004.

55

102. Ponikau JU, Sherris DA, Weaver A, Frigas E, Kita H: Treatment of chronic rhinosinusitis with intranasal Amphotericin B: A randomized, placebo-controlled, double-blind trial. J Allergy Clin Immunol. 115:125-131, 2005.

*103. Shin S-H, Lee YA, Bae YS, Kita H, Kim Y, Ryu SH: The synthetic chemoattractant peptide

WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2. Int Arch Allergy Immunol. 137:21-26, 2005.

104. Ponikau JU, Sherris DA, Kephart GM, Kern EB, Congdon D, Adolphson CR, Gleich GJ, Springett

M, Kita H: Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis. J Allergy Clin Immunol. 116:362-369, 2005.

105. Rhadhakrishnan S, Iijima K, Kobayashi T, Kita H, Pease LR: Dendritic cell activated by cross-

linking B7-DC (PD-L2) block inflammatory airway diseases. J Allergy Clin Immunol. 116:668-674, 2005.

*106. Bartemes KR, Cooper KM, Drain KL, Kita H: Secretory IgA induces antigen-independent

eosinophil survival and cytokine production without inducing effector functions. J Allergy Clin Immunol. 116:827-835, 2005.

*107. Inoue Y, Matsuwaki Y, Sin SH, Ponikau JU, Kita H: Non-pathogenic, environmental fungi induce

activation and degranulation of human eosinophils. J Immunol. 175:5439-5447, 2005. 108. Sedgwick JB, Jansen KJ, Kennedy JD, Kita H, Busse WW: Effects of the very late adhesion

molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions. J Allergy Clin Immunol. 116:812-819, 2005.

*109. Shin M-H, Chung YB, Kita H: Degranulation of human eosinophils induced by paragonismus

westermani-secreted protease. Korean J Parasitol. 43:33-37, 2005. PMCID:PMC2712007. *110. Volcheck GW, Kelkar P, Bartemes KR, Gleich GH, Kita H: Effects of (r)- and (s)-isomers of beta

adrenergic agonists on eosinophil response to IL-5. Clin Exp Allergy. 35:1341-1346, 2005. 111. Van Keulen V, Ciric B, Radhakrishnan S, Heckman K, Matsunaga Y, Iijima K, Kita H, Rodriguez

M, Pease L: Immunomodulation using the recombinant monoclonal human B7-DC crosslinking antibody rHIgM12. Clin Exp Immunol. 143:314-321. 2006. PMCID:PMC1809594.

112. Rajagopalan G, Iijima K, Kita H, David CS: Intranasal exposure to bacterial superantigens

induces airway inflammation in HLA class II transgenic mice. Infect Immu. 74:1284-1296, 2006. PMCID:PMC1360368.

113. Rajagopalan G, Sen MM, Singh M, Murali NS, Nath KA, Iijima K, Kita H, Leontovich AA,

Gopinathan U, Patel R, David CS: Intranasal exposure to staphylococcal enterotoxin B elicits an acute systemic inflammatory response. Shock 25:647-656, 2006.

114. Logan MR, Lacy P, Odemuyiwa SO, Steward M, Davoine F, Kita H, Moqbel R: A critical

role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy 61:777-784, 2006.

115. Juhn YJ, Kita H, Lee LA, Swanson RJ, Smith R, Bagniewski SM, Weaver AL, Pankratz VS,

56

Jacobson RM, Poland GA: Childhood asthma and measles vaccine response. Ann Allergy Asthma Immunol. 97:469-476, 2006.

116. Guedes AGP, Paulin J, Rivero-Nava L, Kita H, Lund FE, Kannan MS: CD38-deficient mice have

reduced airway hyperresponsiveness following IL-13 challenge. Am J Physiol Lung Cell Mol Phys. 291:L1286-1293, 2006.

*117. Yamazaki K, Murray JA, Arora AS, Alexander JA, Butterfield JH, Smyrk TC, Kita H: Allergen-

specific, in vitro cytokine production in adult patients with eosinophilic esophagitis. Dig Dis Sci. 51:1934-1941, 2006.

118. Ponikau JU, Sherris DA, Kephart GM, Adolphson C, Kita H. The role of ubiquitous airborne fungi

in chronic rhinosinusitis. Clin Rev Allergy Immunol. 30:187-194, 2006. 119. Frigas E, park MA, Matesic D, Bachman KA, Volcheck GW, Gustafson RO, Friedman O,

Pallanch JF, Lane JI, Welker KM, Severson RJ, Butterfield JH, Hagan JB, Li JT, Schroeder DR, Kita H. A pilot, prospective, double blind, placebo-controlled treatment trial with Itraconazole orally in patients with chronic rhinosinusitis and asthma. J Allergy Clin Immunol. 119:1025, 2007.

120. Juhn YJ, Kita H, Lee LA, Smith RW, Bagniewski SM, Weaver AL, Pankratz VS, Jacobson RM,

Poland GA: Childhood asthma and human leukocyte antigen type. Tissue Antigens. 69:38-46, 2007.

121. Taneja V, Behrens M, Cooper LT, Yamada S, Kita H, Redfield MM, Terzic A, David C:

Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice. J Mol Cell Cardiol. 42:1054-1064, 2007. PMCID:PMC1993806.

122. Juhn YJ, Kita H, Bagniewski SM, Weaver AL, Pankratz VS, Jacobson RM, Poland GA: Severity

of childhood asthma and human leukocyte antigens type. J Asthma 44:163-168, 2007. 123. Sarkaria JN, Schwingler P, Schild SE, Grogan PT, Mladek AC, Mandrekar SJ, Tan AD,

Kobayashi T, Marks RS, Kita H, Miller RC, Limper AH, Leof EB: Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer. J Thorac Oncol. 2:751-757, 2007.

*124. Yoon J, Terada A, Kita H: CD66b regulates adhesion and activation of human eosinophils. J

Immunol. 179:8454-8462, 2007. *125. Yamazaki K, Murray JA, Kita H: Innate immunoregulatory effects of cereal grains through

induction of interleukin-10. J Allergy Clin Immunol. 121:172-178, 2008. PMID17919702 126. Guedes AGP, Paulin J, Rivero-Nava L, Kita H, Lund FE, Kannan MS: Role of CD38 in TNF-α-

induced airway hyperresponsiveness. Am J Physiol: Lung Cell Mol Physiol. 294:L290-299, 2008. 127. Frigas E, Park MA, Narr BJ, Volcheck GW, Danielson DR, Markus PJ, Kloos Olson KE,

Schroeder DR, Kita H: Preoperative Evaluation of Patients With History of Allergy to Penicillin: A Comparison of Two Models of Practice. Mayo Clin Proc. 83:651-662, 2008.

57

128. Mehta V, Campeau NG, Kita H, Hagan JB: Blood and sputum eosinophilia in asthma and its relationship to sinus CT findings. Mayo Clin Proc. 83:671-678, 2008. PMCID: PMC2824564

*129. Cherry W, Yoon J, Iijima K, Kita H: A novel IL-1 family cytokine, IL-33, activates and enhances

survival of human eosinophils. J Allergy Clin Immunol. 121:1484-1490, 2008. PMCID: PMC2821937

*130. Yoon J, Ponikau JU, Lawrence CB, Kita H: Innate anti-fungal immunity of human eosinophils

mediated by a β2-integrin CD11b. J Immunol. 181:2907-2915, 2008. PMCID: PMC2614918 131. Kroening PR, Barnes TW, Pease L, Limper A, Kita H, Vassallo R: Cigarette smoke-induced

oxidative stress suppresses generation of dendritic cell interleukins-12 and 23 through ERK-dependent pathways. J Immunol. 181:1536-1547, 2008. PMCID: PMC2819390

132. Vassallo R, Kroening PR, Parambil J, Kita H: Nicotine and oxidative cigarette smoke constituents

induce immune-modulatory and pro-inflammatory dendritic cell response. Mol Immunol. 45:3321-3329, 2008. PMCID: PMC2857673

133. Juhn YJ, Kita H, Yawn BP, Boyce TG, Yoo KH, McGree ME, Weaver AL, Wollan P, Jacobson

RM: Increased risk of serious pneumococcal disease in patients with asthma. J Allergy Clin Immunol. 122:719-723, 2008. PMCID: PMC2811957

134. Ulrich M, Petre A, Youhnovski N, Prömm F, Schirle M, Schumm M, Pero RS, Doyle A, Checkel J,

Kita J, Thiyagarajan N, Acharya KR, Schmid-Grendelmeier P, Simon H-U, Schwarz H, Tsutsui M, Shimokawa H, Bellon G, Lee JJ, Przybylski M, Döring G, Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil eroxidase. J Biol Chem. 283:28629-28640, 2008. PMCID: PMC2661412

135. Chung YB, Kita H, Shin MH. A 27 kDa cysteine protease secreted by newly excysted

Paragonimus westermani metacercariae induces superoxide anion production and degranulation of human eosinophils. Korean J Parasitol. 46:95-99, 2008. PMCID: PMC2532610

136. Plager DA, Henke SA, Matsuwaki Y, Madaan A, Squillace DL, Dierkhising RA, Parneix-Spake A,

Kita H. Pimecrolimus reduces calcium-dependent eosinophil activation. Int Arch Allergy Immunol. 149:119-126, 2009. PMCID: PMC2718564

*137. Kim HB, Kim CK, Iijima K, Kobayashi T, Kita H. Protein microarray analysis in patients with

asthma: elevation of chemokine PARC/CCL18 in sputum. Chest. 135:295-302, 2009. PMCID: PMC2835338.

138. Benson LM, Mason CJ, Friedman O, Kita H, Bergen HR III, Plager DA. Extensive fractionation

and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients. J Sep Sci. 32:44-56, 2009. PMCID: PMC2847787

*139. Kobayashi T, Iijima K, Radhakrishnan S, Mehta V, Vassallo R, Lawrence CB, Cyong JC, Pease

LR, Oguchi K, Kita H. Asthma-related environmental fungus, alternaria, activates dendritic cells and produces potent Th2 adjuvant activity. J Immunol. 182:2502-2510, 2009. PMCID: PMC2653279.

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140. Kang CI, Rouse M, Patel R, Kita H, Juhn Y. Allergic airway inflammation and susceptibility to pneumococcal pneumonia in a murine model with real-time in vivo evaluation. Clin Exp Immunol. 156:552-561, 2009. PMCID: PMC2691986

*141. Rank MA, Kobayashi T, Kozaki H, Bartemes KR, Squillace DL, Kita H. IL-33-activated dendritic

cells induce an atypical Th2-type response. J Allergy Clin Immunol. 123:1047-1054, 2009. PMCID: PMC2711963

142. Melkamu T, Squillace D, Kita H, O’Grady SM. Regulation of TLR2 expression and function in

human airway epithelial cells. J Memb Biol. 229:101-113, 2009. *143. Kouzaki H, O’Grady SM, Lawrence CB, Kita H. Protease induce production of thymic stromal

lymphopoietin by airway epithelial cells through protease-activated receptor-2. J Immunol. 183:1427-1434, 2009. PMCID: PMC2706924

144. Bankers-Fulbright JL, Bartemes KR, Kephart GM, Kita H, O’Grady SM. β2-integrin-mediated

adhesion and intracellular Ca2+ release in human eosinophils. J Memb Biol. 228:99-109, 2009. PMCID: PMC2718571

145. Chakrabarti A, Denning DW, Ferguson BJ, Ponikau J, Buzina W, Kita H, Marple B, Panda N,

Vlaminck S, Kauffmann-Lacroix C, Das A, Singh P, Taj-Aldeen SJ, Kantarcioglu AS, Handa KK, Gupta A, Thungabathra M, Shivaprakash MR, Bal A, Fothergill A, Radotra BD, Fungal rhinosinusitis – a categorization and definitional scheme, addressing current controversies. Larygoscope. 119:1809-1818, 2009. PMCID: PMC2741302

*146. Matsuwaki Y, Wada K, White TA, Benson LM, Charlesworth MC, Checkel JL, Inoue Y, Hotta K, Ponikau JU, Lawrence CB, Kita H. Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils. J Immunol. 183: 6708-6716, 2009. PMCID: PMC2843542.

147. Rank MA, Adolphson CR, Kita H. Antifungal therapy for chronic rhinosinusitis: the controversy

persists. Curr Opin Allergy Clin Immunol. 9:67-72, 2009. PMCID:PMC3914414. 148. Kephart GM, Alexander JA, Arora AS, Romero Y, Smyrk T, Talley NJ, Kita H. Marked deposition

of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis. Am J Gastro. 105:298-307, 2010. PMCID: PMC2824254.

149. Straumann A, Conus S, Grzonka P, Kita H, Kephart G, Bussmann C, Beglinger C, Smith DA,

Patel J, Byrne M, Simon H-U. Anti-Interleukin-5 antibody treatment (Mepolizumab) in active eosinophilic esophagitis: A randomized, placebo-controlled, double-blind trial. Gut. 59:21-30, 2010.

150. Hagan JB, Park MA, Kita H, Campeau NG. Reduced Immunoglobulin M Is Associated with Sinus

Mucosal Thickening, Osteitis and Sinus Surgery in Patients with Common Variable Immunodeficiency. Int Arch Allergy Immunol. 152:81-86, 2010. PMCID:PMC3202961.

151. Jung JA, Kita H, Yawn BP, Boyce TG, Yoo KH, McGee ME, Weaver AL, Wollan P, Jacobson RM,

Juhn YJ. Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma. J Allergy Clin Immunol. 125:217-221, 2010. PMCID: PMC2825162

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152. Bates ME, Sedgwick JB, Zhu Y, Liu LY, Heuser RG, Jarjar N, Kita H, Bertics PJ. Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin and activation of the RAS/ERK pathway when compared with blood eosinophils. J Immunol. 184:7125-7133, 2010. PMCID: PMC2901505.

153. Wada K, Matsuwaki Y, Yoon J, Benson LM, Checkel JL, Bingemann TA, Kita H. Inflammatory

responses of human eosinophils to cockroach are mediated through protease-dependent pathways. J Allergy Clin Immunol. 126:169-172, 2010. PMCID: PMC2902556

*154. Kobayashi T, Kouzaki H, Kita H. Human eosinophils recognize endogenous danger signal

crystalline uric acid and produce pro-inflammatory cytokines mediated by autocrine ATP. J Immunol. 184:6350-6358, 2010. PMCID: PMC2874987.

155. Rank MA, Wollan P, Kita H, Yawn BP. Acute exacerbations of chronic rhinosinusitis occur in a

distinct seasonal pattern. J Allergy Clin Immunol. 126:168-169, 2010. PMCID:PMC3919526. 156. Li JT, Rank MA, Squillace DL, Kita H. Ovalbumin content of influenza vaccines. J Allergy Clin

Immunol. 125:1412-1413, 2010. PMCID: PMC2927356 157. Kim CK, Choi J, Callaway Z, Volcheck G, Kita H. Increases in airway eosinophilia and Th1

cytokine during the chronic asymptomatic phase of asthma. Resp Med. 10:1436-1443, 2010. PMCID:PMC3899099.

158. Kim CK, Kita H, Callaway Z, Kim HB, Choi J, Fujisawa T, Shin BM, Koh YY. The roles of a Th2

cytokine and CC chemokine in children with stable asthma: Potential implication in eosinophil degranulation. Pediatr Allergy Immunol. 2010 21:e697-704. PMCID:PMC3899091.

159. Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JP, Friedman O, Kita H. Gene

transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE. 2010; 5(7):e11450. Epub 2010. PMCID:PMC2897889.

160. Jung JA, Kita H, Dhillon R, Jacobson R, Nahn M, Park M, Tsigrelis C, Juhn Y. Influence of

asthma status on serotype-specific pneumococcal antibody levels. Postgrad Med. Sept 122:116-124, 2010.

161. Grothe RM, Thompson DM, Perrault JF, Kita H, Lee JJ, Romero Y. Eosinophilic esophagitis in

the pediatric patient—an update. US Ped. 5:39-45, 2010. 162. Zhao H, Kang C, Rouse M, Patel R, Kita H, Juhn Y. The Role of IL-17 in the Association

between Pneumococcal Pneumonia and Allergic Sensitization. Int J Microbiol. E-Pub 709509, 2011. PMCID:PMC3227511.

*163. Muraki M, Gleich GJ, Kita H. Antigen-specific IgG and IgA, but not IgE, activate the effector

functions of eosinophils in the presence of antigen. Int Arch Allergy Immunol. 154:119-127, 2011. PMID:20733320.

*164. Kouzaki H, Iijima K, Kobayashi T, O’Grady SM, Kita H. The danger signal, extracellular ATP, is a

sensor for an airborne allergen and triggers IL-33 release and innate TH2-type responses. J Immunol. 186:4375-4387, 2011. PMCID:PMC3062674.

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165. Pasha SF, Crowell MD, Alexander JA, Harris LA, Achem SR, Farrugia G, Lee JJ, Thompson DM, Jung KW, Kita H, Ravi K, Namasivayam V, Kim HJ, Fleischer DE, Sharma VK, Romero Y. Eosinophilic esophagitis in adults-A rising epidemic. Euro Gastroenterol Hepatol Review. 7:14-720, 2011.

166. Ishioka T, Kimura1 H, Kita H, Obuchi M, Hoshino H, Noda M, Nishina A, Kozawa K, Kato M.

Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549). Cell Biol Int. 35:467-474, 2011.

167. Kita H. Is ROG, repressor of GATA, a specific regulator of Th2-type immune response? Clin

Immunol. 139:235-237, 2011. *168. Rajagopalan G, Tilahun AY, Iijima K, David CS, Kita H, Juhn YJ. HLA-DR polymorphism

modulates response to house dust mites in a transgenic mouse model of airway inflammation. Tissue Antigens. 77:589-592, 2011.

*169. Wada K, Matsuwaki Y, Moriyama H, Kita H. Cockroach induces inflammatory responses through

protease-dependent pathways. Int Arch Allergy Immunol. 155 Suppl 1:135-141, 2011. PMID:21646809.

*170. Matsuwaki Y, Wada K, Moriyama H, Kita H. Human eosinophil innate response to alternaria

fungus through protease-activated receptor-2. Int Arch Allergy Immunol. 155 Suppl 1:123-128, 2011. PMID:21646807.

171. Hosoki K, Nagao M, Iguchi K, Ihara T, Yamada Y, Higashigawa M, Kephart GM, Kita H, Fujisawa

T. An 8-year-old boy with hypereosinophilic syndrome. Int Arch Allergy Immunol. 155 Suppl 1:117-122, 2011. PMID:21646806.

172. Kita H. Eosinophils: multifaceted biological properties and roles in health and disease. Immunol

Rev. 242:161-177, 2011. PMCID:PMC3139217. 173. Hagan JB, Taylor RL, Kita H, Singh RJ. Analysis of fluticasone propionate in induced sputum by

mass spectrometry. Allergy Asthma Proc. 32:18-21, 2011. 174. Lim KG, Rank MA, Kita H, Patel A, Moore E. Neuropeptide levels in nasal secretions from

patients with and without chronic cough. Ann Allergy Asthma Immunol. 107:360-363, 2011. *175. Brickshawana A, Spairo VS, Kita H, Pease LR. Lineage-Sca1+c-Kita-CD25+ cells are IL-33-

responsive type 2 innate cells in the mouse bone marrow. J Immunol. 187:5795-5804, 2011. PMCID:PMC4449734.

*176. Kim CK, Callaway Z, Kim DW, Kita H. Eosinophil degranulation is more important than

eosinophilia in identifying asthma in chronic cough. J Asthma. 48:994-1000, 2011. 177. Lee J, Zhao H, Fenta Y, Kita H, Kumar R, Juhn YJ. Serum 25-hydroxyvitamin D is associated

with enhanced pneumococcal antibody levels in individuals with asthma. Allergy Asthma Proc. 32:445-52, 2011.

178. Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs, A, Greenberger PA, Kariuki B,

Kita H, Karup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ. Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol. 129:280-291, 2012.

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179. Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H. IL-33-Responsive

Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type-2 Immunity and Allergic Inflammation in the Lungs. J Immunol. 188:1503-1513, 2012. PMCID:PMC3262877.

180. Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH,

Panettieri RA, Schleimer RP, Minnicozzi M. Asthma outcomes: Biomarkers. J Allergy Clin Immunol. 129:S9-23, 2012. PMCID:PMC3390196.

181. Sridhara S, Ravi K, Smyrk TC, Kita H, Kephart GM, Weiler C, Katzka DA. Increased numbers of

eosinophils, rather than only etiology, predict histologic changes in patients with esophageal eosinophilia. Clin Gastroenterol Hepatol. 10:735-741, 2012.

*182. Matsuwaki Y, Wada K, White T, Moriyama, H., Kita H. Fungus, alternaria, induces GM-CSF, IL-6,

and IL-8 production and calcium signaling in human airway epithelium through protease-activated receptor-2 (PAR-2). Int Arch Allergy Immunol. 158:19-29, 2012. PMCID:PMC3395436.

183. Alexander JA, Jung KW, Arora AS, Enders F, Katzka DA, Kephart GM, Kita H, Kryzer LA,

Romero Y, Smyrk TC, Talley NJ. Swallowed Fluticasone Improves Histologic but not Symptomatic Responses of Adults with Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 10:742-749, 2012.

184. Kato M, Ishioka T, Kita H, Kozawa K, Hayashi Y, Kimura H. Eosinophil granular proteins damage

bronchial epithelial cells infected with respiratory syncytial virus. Int Arch Allergy Immunol. 158:11-18, 2012.

185. Hosoki K, Hirayama M, Kephart G, Kita H, Nagao M, Uchizono H, Toyoda H, Senba Y, Imai Y,

Komada Y, Ihara T, Fujisawa T. Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease. Int Arch Allergy Immunol. 158:70-74, 2012.

*186. Plager D, Torres SM, Koch SN, Kita H. Gene transcription abnormalities in canine atopic

dermatitis and related human eosinophilic allergic diseases. Vet Immunol Immunopath. 149:136-142, 2012. PMCID:PMC4459581.

*187. Neff BA, Voss SG, Schmitt WR, Driscoll CL, Link MJ, Beatty CW, Kita H. Inhibition of MEK

pathway in vestibular schwannoma cell culture. Laryngoscope. 122:2269-2278, 2012. 188. Guo C, Ghadersohi S, Kephart GM, Laine RA, Sherris DA, Kita H, Ponikau JU. Improving the

detection of fungi in eosinophilic mucin: Seeing what we could not see before. Otolaryngol Head Neck Surg. 147:943-949, 2012.

189. Rank MA, Hagan JB, Samant SA, Kita H. A proposed model to study immunologic changes

during chronic rhinosinusitis exacerbations: Data from a pilot study. Am J Rhinol Allergy 27:98-101, 2013. PMCID:PMC3610944

190. Melkamu T, Kita H, O’Grady SM. TLR3 activation evokes IL-6 section, autocrine regulation of

Stat3 signaling and TLR2 expression in human bronchial epithelial cells. J Cell Commun Signal. 7:109-118, 2013. PMCID:PMC3660690

62

191. Rank MA, Kita H, Li JT, Butterfield JH. Systemic reactions to allergen immunotherapy: A role for measuring a PGD2 metabolite. Ann Allergy Asthma Immunol. 110:57-58, 2013.

192. Wada K, Kobayashi T, Matsuwaki Y, Moriyama H, Kita H. Alternaria inhibits double-stranded RNA-induced cytokine production through TLR3. Int Arch Allergy Immunol. 161 Suppl 2:75-83,

2013. PMCID:PMC3904297 193. Zhao H, Jung JA, Briles DE, Kita H, Tsigrelis C, Juhn YJ. Asthma and antibodies to

pneumococcal virulence proteins. Infection. 41:927-934, 2013. PMCID:PMC3778049. 194. O’Grady SM, Patil N, Melkamu T, Maniak P, Lancto C, Kita H. ATP release and Ca2+ signaling

by human bronchial epithelial cells following Alternaria aeroallergen exposure. J Physiol. 2013 591:4595-4609, 2013. PMCID:PMC3784201.

*195. Kobayashi T, Iijima K, Checkel JJ, Kita H. Interleukin-1-family cytokines drive T helper 2 and 7

cells to innocuous airborne antigens. Am J Respir Cell Mol Biol. 49:989-998, 2013. PMCID:PMC3931108

*196. Kouzaki H, Tojima I, Kita H, Shimizu T. Transcription of interleukin-25 and extracellular release

of the protein is regulated by allergen proteases in airway epithelial cells. Am J Respir Cell Mol Biol. 49:741-750, 2013.

197. Babiceanu M, Howard B, Rumore A, Kita H, Lawrence C. Analysis of global gene expression

changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, alternaria alternate. Front Microbiol. 4:196, 2013. PMCID:PMC3715730

198. Ryoo E, Kumar R, Kita H, Juhn YJ. Serum 25-hydroxyvitamin D concentrations and waning

pneumococcal antibody titers among individuals with atopy. Allergy Asthma Proc. 34:370-377, 2013.

199. Wong TW, Kita K, Hanson CA, Walters DK, Arendt BK, Jelinek DF. Induction of malignant

plasma cell proliferation by eosinophils. PLoS One. 8(7):e70554, 2013. PMCID:PMC3718740 200. Pallanch J, Yu L, Delone D, Robb R, Holmes DR, Camp J, Edwards P, McCollough CH, Ponikau

J, Dearking A, Lane J, Primak A, Shinkle A, Hagan J, Frigas E, Ocel JJ, Tombers N, Siwani R, Orme N, Reed K, Jerath N, Dhillon R, Kita H. 3-D volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring. Int Forum Allergy Rhinol. 3:963-972, 2013. PMCID:PMC3971423

201. Likness MM, Pallanch JF, Sherris DA, Kita H, Mashtare TL Jr, Ponikau JU. Computed

tomography scans as an objective measure of disease severity in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 150:305-311, 2014. PMCID:PMC3986264

202. Kay A. Barry, Ying S, Ardelean E, Mlynek A, Kita H, Clark P, Maurer M. Elevations in vascular

markers and eosinophils in chronic spontaneous urticarial weals with low level persistence in uninvolved skin. Br J Dermatol. 171:505-511, 2014. PMCID:PMC4282040.

203. Hara K, Iijima K, Elias MK, Seno S, Tojima I, Kobayashi T, Kephart GM, Kurabayashi M, Kita H.

Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol. 192:4032-4042, 2014. PMCID:PMC4013745

63

204. Okuyama K, Dobashi K, Miyasaki T, Yamazaki N, Kikuchi T, Sora I, Takayanagi M, Kita H, Ohno

I. The involvement of glucocorticoids in psychological stress-induced exacerbations of experimental allergic asthma. Int Arch Allergy Immunol. 163:297-306, 2014.

205. Drake L, Iijima K, Kita H. Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate

type 2 immune response in mice. Allergy. 69:1300-1307, 2014. PMCID:PMC4160406 206. Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, Kuroda K,

Nunomura S, Hayama K, Terui T, Ra C, Okayama Y. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. J Allergy Clin Immunol. 134:622-633, 2014.

207. Kay A. Barry, Ying S, Ardelean E, Mlynek A, Kita H, Clark P, Maurer M. CGRP and VEGF are

expressed in lesional but not uninvolved skin in chronic spontaneous urticaria. Clin Exp Allergy. 44:1053-1060, 2014.

208. Iijima, K, Kobayashi T, Hara K, Kephart GM, Ziegler SF, McKenzie AN, Kita H. IL-33 and thymic

stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure. J Immunol. 193:1549-1559, 2014. PMCID:PMC4119518.

209. Bartemes K, Kephart G, Fox S, Kita H. Enhanced type 2 immune response in peripheral blood

from patients with asthma. J Allergy Clin Immunol. 134:671-678, 2014. PMCID:PMC4149890. 210. Podjasek JC, Jung JA, Kita H, Park MA, Juhn YJ. The FACT score in predicting pneumococcal

antibody levels in asthmatics. J Asthma. 52:370-375, 2015. 211. Katzka DA, Geno DM, Ravi A, Smyrk TC, Lao-Sirieix P, Miramedi A, Debiram I, O’Donovan M,

Kita H, Kephart GM, Kryzer LA, Camilleri M, Alexander JA, Fitzgerald RC. Accuracy, safety, and tolerability of tissue collection by cytosponge vs endoscopy for evaluation of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 13:77-83 e72, 2015.

212. Ponikau JU, Winter LA, Kephart GM, Squillace DL, Hershcovitch MD, Moon S, Sherris DA, Kern

EB, Gleich GJ, Kita H. An immunological test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein. Int Forum Allergy Rhinol. 5:28-35, 2015.

213. Divekar R, Samant S, Rank MA, Hagan J, Lal D, O’Brien EK, Kita H. Immunological profiling in

chronic rhinosinusitis with nasal polyps reveals distinct VEGF and GMCSF signatures during symptomatic exacerbations. Clin Exp Allergy. 45:767-778, 2015. PMCID:PMC4459602.

214. Guedes AG, Jude JA, Paulin J, Rivero-Nava L, Kita H, Lund FE, Kannan MS. Airway

responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimeras. Am J Physiol Lung Cell Mol Physiol. 308:L485-493, 2015. PMCID:PMC4346775.

215. Drake LY, Iijima K, Hara K, Kobayashi T, Kephart GM, Kita H. B cells play key roles in Th2-type

airway immune responses in mice exposed to natural airborne allergens. PLoS One. 109(3):e0121660, 2015. PMCID:PMC4372217

216. Yarova PL, Stewart AL, Sathish V, Britt RD, Jr., Thompson MA, P Lowe AP, Freeman M,

Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ,

64

Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Science Trans Med. 7:284ra260;2015. PMCID:PMC4725057.

217. Escalante P, Peikert T, Van Keulen VP, Erskine CL, Bornhorst CL, Andrist BR, McCoy K, Pease

LR, Abraham RS, Knutson KL, Kita H, Schrum AG, Limper AH. Combinatorial immunoprofiling in latent tuberculosis infection: Toward better risk stratification. Am J Respir Crit Care Med. 192:605-617, 2015. PMCID:PMC4595688.

218. Kobayashi T, Soma T, Noguchi T, Nakagome K, Nakamoto H, Kita H, Nagata M. ATP drives

eosinophil effector responses through P2 purinergic receptors. Allergol Int. 64 Suppl:S30-36, 2015. PMCID:PMC4595162.

219. Divekar R, Patel N, Jin J, Hagan J, Rank M, Lal D, Kita H, Brien E. Symptom-based clustering in

chronic rhinosinusitis relates to history of aspirin sensitivity and postsurgical outcomes. J Allergy Clin Immunol Pract. 3:934-940, 2015. PMCID:PMC4641837.

220. Wada K, Kobayashi T, Matsuwaki Y, Moriyama H, Kita H. Alternaria inhibits double-stranded

RNA-induced cytokines productions through TLR3. Practica Otologica, Suppl. 143:117-126, 2015. 221. Anderson EL, Kobayashi T, Iijima K, Bartemes KR, Chen CC, Kita H. IL-33 mediates reactive

eosinophilopoiesis in response to airborne allergen exposure. Allergy 71:977-988, 2016. PMCID:PMC5107318.

*222. Tojima I, Kouzaki H, Shimizu S, Ogawa K, Arikata M, Kita H, Shimizu T. Group 2 innate lymphoid

cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis. Clin Immunol. 170:1-8, 2016.

223. Drake LY, Iijima K, Bartemes KR, Kita H. Group 2 innate lymphoid cells promote an early

antibody response to a respiratory antigen in mice. J Immunol. 197:1335-1342, 2016. PMCID:PMC4976030.

224. Sheen YH, Rajagopalan G, Snapper CM, Kita H, Wi CI, Umaretiya PJ, Juhn YJ. Influence of

HLA-DR polymorphism and allergic sensitization on humoral immune response to intact Phemococcus in a transgenic mouse model. HLA. 88:25-34, 2016.

225. Divekar R, Hagan J, Rank M, Park M, Volcheck G, O’Brien E, Meeusen J, Kita H, Butterfield J.

Diagnositic utility of urinary LTE4 in asthma, allergic rhinitis, chronic rhinosinusitis, nasal polyps and aspirin sensitivity. J Allergy Clin Immunol Pract. 4:665-670, 2016. PMCID:PMC5103699.

226. Kobayashi T, Iijima K, Dent AL, Kita H. Follicular helper T cells mediate IgE antibody response to

airborne allergens. J Allergy Clin Immunol. 139:300-313, 2017. PMCID:PMC5115999. 227. Chen CC, Kobayashi T, Iijima K, Hsu FC, Kita H. IL-33 dysregulates regulatory T (Treg) cells and

impairs established immunological tolerance in the lungs. J Allergy Clin Immunol. 2017 Feb 11. pii: S0091-6749(17)30228-2. doi: 10.1016/j.jaci.2017.01.015. [Epub ahead of print]

228. Hagan JB, Laidlaw TM, Divekar R, O’Brien EK, Kita H, Volcheck GW, Hagan CR, Lal D, Teaford

HG, Erwin PJ, Zhang N, Rank MA. Urinary leukotriene E4 to determine aspirin intolerance in

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asthma: a systematic review and metaanlysis. J Allergy Clin Immunol Pract. 2017 Feb 12. pii: S2213-2198(16)30560-8. doi: 10.1016/j.jaip.2016.11.004. [Epub ahead of print]

229. Kouzaki H, Matsumoto K, Kikuoka H, Kato T, Tojima I, Shimizu S, Kita H, Shimizu T.

Endogenous Protease Inhibitors in Airway Epithelial Cells Contribute to Eosinophilic Chronic Rhinosinusitis. Am J Resp Crit Care Med. 195:737-747, 2017.

230. Uchida M, Anderson EL, Squillace DL, Patil N, Maniak PJ, Iijima K, Kita H, O'Grady SM.

Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium. Allergy. 2017 Mar 8. doi: 10.1111/all.13158. [Epub ahead of print]

231. Schafer, MJ. White, TA. Iijima, K. Haak, AJ. Ligresti, G. Atkinson, EJ. Oberg, AL. Birch, J.

Salmonowicz, H. Zhu, Y. Mazula, DL. Brooks, RW. Fuhrmann-Stroissnigg, H. Pirtskhalava, T. Prakash, YS. Tchkonia, T. Robbins, PD. Aubry, MC. Passos, JF. Kirkland, JL. Tschumperlin, DJ. Kita, H. LeBrasseur, NK. Cellular senescence mediates fibrotic pulmonary disease. Nat Comm. 8: 14532; 2017. doi: 10.1038/ncomms14532. PMCID:PMC5331226.

232. Divekar R, Rank M, Squillace D, Kita H, Lal D. Unsupervised network mapping of commercially

available immunoassay yields three distinct chronic rhinosinusitis endotypes. Int Forum Allergy Rhinol. 7:373-379, 2017.

233. Racette SD, Wijewickrama RC, Jayaprakash V, Sherris DA, Santos C, Kita H, O'Donnell FE, Jr.,

Ponikau JU. Correlation of Symptoms, Clinical Signs, and Biomarkers of Inflammation in Postsurgical Chronic Rhinosinusitis. Ann Otol Rhinol Laryngol. 126:455-462, 2017.

234. Wi CI, Sohn S, Rolfes MC, Seabright A, Ryu E, Voge G, Bachman KA, Park MA, Kita H, Croghan

IT, Liu H, Juhn YJ. Application of a Natural Language Processing Algorithm to Asthma Ascertainment: An Automated Chart Review. Am J Resp Crit Care Med, 2017. Epub ahead of print.

235. Zaidman NA, O'Grady KE, Patil N, Milavetz F, Maniak PJ, Kita H, O'Grady SM. Airway epithelial

anion secretion and barrier function following exposure to fungal aeroallergens: Role of oxidative stress. Am J Physiol Cell Physiol.ajpcell 00043 02017, 2017. Epub ahead of print.

Published Books and Book Chapters

1. Abu-Ghazaleh RI, Kita H, Gleich GJ: Eosinophil activation and function in health and diseases. In: Coffey RG: Granulocyte Responses to Cytokines: Basic and Clinical Research. New York. Marcel Decker, Inc., Immunology Series 57:137-167, 1992.

2. Kita H: Mechanism and regulation of eosinophil degranulation. Clin Immunol (Jpn) 24:532-541,

1992. 3. Gleich GJ, Butterfield JH, Leiferman KM, Kita H, Abrams J: Eosinophils, allergic diseases and

cytokines. In: Miyamoto T, Okuda M: Progress in Allergy Clinical Immunology. Seattle. Hogrefe and Huber Publishers. Volume 2, pp. 440-444, 1992.

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4. Belongia EA, Mayeno AN, Gleich GJ, Kita H: Eosinophilia-myalgia syndrome. In: Makino S and Fukuda T: Eosinophils. Biological and clinical aspects. Boca Raton. CRC Press, Inc. pp. 421-438, 1993.

5. Gleich GJ, Kita H, Adolphson CR: Eosinophils. In: Frank MM, Austen KF, Claman HN, Unanue

ER: Samter’s Immunological Diseases. Fifth edition. Boston. Little Brown and Company. pp. 205-245, 1995.

6. Kita H: Eosinophils. Receptors and signal transduction. In: Lad PM: Signal transduction in

leukocytes: Role of G protein-related and other pathways. Boca Raton. CRC Press. pp. 285-322, 1995.

7. Kita H: Eosinophil degranulation (Jpn). In: Makino S, Ishikawa T: Respiratory Allergy 95. Tokyo.

Medical Review. pp. 97-110, 1995. 8. Kita H, Gleich GJ: The eosinophil: structure and functions. In: Kaplan AP: Allergy. Second

Edition. Philadelphia. W. B. Saunders Company. pp. 148-178, 1997. 9. Kita H: Regulation of eosinophil mediator release by adhesion molecules. In: Bochner BS:

Adhesion molecules in allergic disease. New York. Marcel Dekker. pp. 227-255, 1997. *10. Kaneko M, Kita H, Gleich GJ: Eosinophil basic proteins. In: Barnes PJ et al: Asthma.

Philadelphia. Lippincott-Raven Publishers. pp. 593-607, 1997. 11. Kita H, Gleich GJ: Roles of eosinophils and neutrophils in fatal asthma. In Sheffer AL: Fatal

Asthma. New York. Marcel Dekker. pp. 157-173, 1998. *12. Motegi Y, Kita H: Eosinophil Fc receptors (Jpn). In: Tomioka T: Molecular Allergology. Tokyo.

Medical Review. pp. 169-174, 1998. 13. Kita H, Adolphson CR, Gleich GJ: Biology of eosinophils. In: Middleton E., Jr., Reed CE, Ellis EF,

Adkinson NF, Jr., Yunginger JW, Busse WW: Allergy: Principles and practice. 5th Ed. St. Louis. Mosby-Year Book, Inc. pp. 242-260, 1998.

14. Gleich GJ, Bankers-Fulbright JL, Okada S, Kita H, Hunt LW: Novel glucocortiomimetic agents

active on eosinophils: potential uses in the therapy of asthma. In: Marone G, Austen KF, Holgate ST, Kay AB, Lichtenstein LM: Asthma and Allergic Diseases: Physiology, Immunopharmacology and Treatment. San Diego. Academic Press Ltd., 1998, pp. 259-268.

15. Kita H: Eosinophil signal transduction. In: Denberg JA: Mechanisms of Allergic Diseases: Basic

and Clinical Aspects. Totowa. Humana Press. pp. 415-444, 1998. *16. Motegi Y, Kita H: Signal transduction mechanisms of eosinophil degranulation (Jpn). In: Allergy

Molecular Medicine: From Basics to Clinics. Tokyo. Gendai-Iryo-Sha. pp.793-799, 1998. 17. Gleich GJ, Adolphson C, Kita H: The eosinophil and asthma. In: Busse W and Holgate S:

Asthma and Rhinitis. Oxford. Second Ed. Blackwell Science. pp. 429-479, 2000.

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18. Yamazaki K, Suzuki K, Kita H, Gleich GJ: Eosinophil activation in primary biliary cirrhosis: a mechanism for cholangiocyte injury? In: Nishioka M, Watanabe S, Arima K: Autoimmune Liver Disease – Its Recent Advances. Amsterdam. Elsevier. pp. 157-170, 2000.

19. Kita H, Adolphson C. Eosinophil IgE receptors. Controversy and Consensus. In: Fick RB and

Jardieu PM: IgE and Anti-IgE in Asthma and Allergic Diseases. Marcel Dekker. pp. 87-101, 2001. 20. Kita H, Adolphson CR, Gleich GJ: Biology of eosinophils. In: Middleton E., Jr., Reed CE, Ellis EF,

Adkinson NF, Jr., Yunginger JW, Busse WW: Allergy: Principles and practice. 6th Ed. St. Louis. Mosby-Year Book, Inc. pp. 305-332, 2003.

21. Ponikau JU, Sherris DA, Kephart GM, Adolphson C, Kita H: The role of ubiquitous airborne fungi

in chronic rhinosinusitis. Clin Rev Allergy Immunol 30:187-94, 2006. 22. Ponikau JU, Sherris DA, Kita H: The Role of Ubiquitous Airborne Fungi in Chronic Rhinosinusitis

In: Hamilos DL, Baroody FM, editors. Chronic Rhinosinusitis: Pathogenesis and Medical Management. Clin Allergy Immunol. New York. Informa Healthcare USA, Inc. vol. 20. pp.177-84, 2007.

23. Kita H, Reed CE, Weiler CR: Protease activated pathway of inflammation In: Adkinson NF, Jr,

Bocher BS, Busse WW, Holgate St, Lemanske RF, Jr, Simons FER.: Middleton’s Allergy: Principles and practice. 7th Ed. Vol 1. Philadelphia: Elsevier; 2009. pp. 423-436.

24. Kita H: Eosinophils In: Zierhut M, Biedermann T, Ono S, editors: Immunology of Ocular Allergy.

Jaypee Brothers Medical Publishers. 5:48-76, 2010.

25. Kita H: Antifungal immunity by eosinophils: Mechanisms and implications in human diseases. In: James Lee and Helene Rosenberg, Editors: Eosinophils in Health and Disease. 1st Edition. London; Waltham:Elsevier; 2012, pp 291-299.

26. Ponikau J, Kita H, Sherris DA. The role of eosinophils in rhinologic diseases. In: Nasal physiology

and pathophysiology of nasal disorders; 95-108, 2013.

27. Kita H, Bochner BS: Biology of eosinophils. In: Adkinson NF, Jr, Bochner BS, Busse WW, Holgate St, Lemanske RF, Jr, Simons FER.: Middleton’s Allergy: Principles and practice. 8th Ed. Philadelphia. Elsevier/Saunders; Vol. 1:265-279, 2014.

Invited Papers

1. Fujisawa T, Kita H, Sur S, Kobayashi K: Eosinophil and neutrophil degranulation in allergic inflammation: Immunohistochemical localization of granule proteins in fatal asthma and stimulus-dependent degranulation in vitro. Nippon Kyobu Shikkan Gakkai Zasshi – Jpn. J Thoracic Dis. (Jpn) 31(Suppl 1):115-124, 1993 (review).

2. Kita H, Kato M, Gleich GJ, Abraham RT: Tyrosine phosphorylation and inositol phosphate

production: Are early events in human eosinophil activation stimulated by immobilized secretory IgA and IgG? J Allergy Clin Immunol. 94:1272-1281, 1994 (review).

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3. Kita H: The eosinophil: A cytokine-producing cell? J Allergy Clin Immunol. 97:889-892, 1996 (editorial).

*4. Martin LB, Kita H, Leiferman KM, Gleich GJ: Eosinophils in allergy: Role in disease,

degranulation, and cytokines. Int Arch Allergy Immunol. 109:207-215, 1996 (review). *5. Levy AM, Kita H: The eosinophil in gut inflammation: effector or director? Gastroenterology

110:952-954, 1996 (editorial). 6. Kita H, Gleich GJ: Chemokines active on eosinophils: Potential roles in allergic inflammation. J

Exp Med. 183:2421-2426, 1996 (editorial). 7. Gleich GJ, Kita H: Bronchial asthma: Lessons from murine models. Proc Natl Acad Sci USA

94:2101-2102, 1997 (editorial). 8. Kita H, Gleich GJ: Eosinophils and IgE receptors: A continuing controversy. Blood 89:3497-3501,

1997 (editorial). *9. Hiraguri M, Kita H: Mechanisms of eosinophil activation and strategy for inhibition (Jpn). Igaku-

no-Ayumi 190: 6633-6637, 1999 (review). *10. Iijima K, Kita H: Regulation of eosinophil activation by adhesion molecules (Jpn). Igaku-no-

Ayumi 192:7190-7195, 2000 (review). *11. Terada A, Kita H: Basic biology of eosinophils and clinical application (Jpn). J Japanese Soc

Ped Hematol 17:1-8, 2003 (review). 12. Ponikau JU, Sherris DA, Kita H, Kern EB: Antifungal nasal washes for chronic rhinosinusitis:

What’s therapeutic--the wash or the antifungal. J Allergy Clin Immunol. 111:1137-1140, 2003 (correspondence).

*13. Davis L, Kita H: Airborne allergens and other pathogens in chronic rhinosinusitis. Immunol

Allergy Clin N Am. 24:59-73, 2004 (review). 14. Reed CE, Kita H: The role of protease activation of inflammation in allergic respiratory diseases.

J Allergy Clin Immunol. 114:997-1008, 2004 (review). 15. Ponikau JU, Sherris DA, Kephart GM, Adolphson C, Kita H: The role of ubiquitous airborne fungi

in chronic rhinosinusitis. Clin Rev Allergy Immunol. 30:187-194, 2006 (review). 16. Rank MA, Adolphson, CR, Kita H. Antifungal therapy for chronic rhinosinusitis: the controversy

persists. Curr Opin Allergy Clin Immunol. 9:67-72, 2009. 17. Kita H. Is ROG, repressor of GATA, a specific regulator of Th2-type immune response? Clin

Immunol. 139:235-237, 2011 (editorial).

18. Bartemes BA, Kita H. Dynamic role of epithelial-derived cytokines in asthma. Clin Immunol. 143:222-235, 2012 (review). PMCID:PMC3358585.

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19. Kita H. Eosinophils: Multifunctional and distinctive properties. Int Arch Allergy Immunol. 161 Suppl 2:3-9, 2013.

20. Drake L, Kita H. Group 2 innate lymphoid cells in the lung. Adv Immunol. 124:1-16, 2014

(review). PMCID:PMC4449733

21. Divekar R, Kita H. Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation. Curr Opin Allergy Clin Immunol. 15:98-103, 2015 (review). PMCID:PMC4346181.

22. Kita H. ILC2s and fungal allergy. Allergology Intl. 64:219-226, 2015 (review).

PMCID:PMC4484772. 23. Drake LY, Kita H. IL-33: biological properties, functions and roles in airway disease. Immunol Rev.

278:173-84, 2017 (review).

CDROMS, Audiotapes, Videotapes None

Abstracts and Letters 1. Kita H, Abu-Ghazaleh RI, Gleich GJ: Effect of corticosteroid on immunoglobulin-induced

eosinophil (EOS) degranulation. J Allergy Clin Immunol. 83:192, 1989. 2. Fujisawa T, Abu-Ghazaleh RI, Kita H, Mestecky J, Sanderson CJ, Gleich GJ: Regulatory effect

of cytokines on eosinophil degranulation. J Allergy Clin Immunol. 83:300, 1989. 3. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT: Regulation of immunoglobulin-induced

eosinophil degranulation by cAMP. J Allergy Clin Immunol. 85:284, 1990. 4. Kita H, Abu-Ghazaleh RI, Gleich GJ, Abraham RT: Inhibition of human eosinophil degranulation

by pertussis toxin. FASEB J. 4:A1942, 1990. 5. Sedgwick JB, Calhoun WJ, Kita H, Gleich GJ, Busse WW: The effect of antigen (Ag) challenge

on the properties of airway eosinophils (EOS). Am Rev Respir Dis. 141:A934, 1990. 6. Goronzy JJ, Weyand CM, Lundy SK, Mayeno AN, Loegering DA, Kita H, Weiler DA, Gleich GJ:

Analysis of implicated and nonimplicated L-tryptophan (LT) lots in a patient with eosinophilia myalgia syndrome (EMS). Arthritis Rheum. 33:S17, 1990

7. Kita H, Abu-Ghazaleh RI, Sanderson CJ, Gleich GJ: Human eosinophils cultured with human

interleukin 5 are hypodense, activated and have a distinctive morphology. J Allergy Clin Immunol. 87:349, 1991.

8. Okubo Y, Kita H, Abrams J, Gleich GJ: Measurement of IL-5 by the eosinophil survival assay. J

Allergy Clin Immunol. 87:349, 1991.

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*9. Wallen ND, Weiler DA, Gleich GJ, Kita H: Glucocorticoids (GC) inhibit rIL-5 enhanced in vitro survival of eosinophils. J Allergy Clin Immunol. 87:173, 1991.

10. Kita H, Weiler DA, Weyand CM, Goronzy JJ, Gleich GJ: Eosinophil-active cytokine from

mononuclear cells cultured with L-tryptophan (LT) products. FASEB J. 5:A641, 1991. 11. Sur S, Kita H, Wagner J, Kephart G, George T, Leiferman KM, Gleich GJ: Localization of

eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophils. FASEB J. 5:A641, 1991.

*12. Okubo Y, Kita H, Weiler D, Abrams J, Gleich GJ: Sensitivity of the eosinophil survival assay for

IL-3, GM-CSF, and IL-5. FASEB J. 5:A641, 1991. *13. Ohnishi T, Kita H, Sedgwick JB, Calhoun WJ, Busse WW, Abrams J, Gleich GJ: IL-5 is the

predominant eosinophil-active cytokine in the pulmonary antigen-induced late phase reaction. Int Cong Allergol Clin Immunol. 1991.

14. Goronzy JJ, Kita H, Lundy SK, Gleich GJ, Weyand CM: Induction of GM-CSF by disease

implicated L-tryptophan (LT) lots in the eosinophilia myalgia syndrome (EMS). Clin Res 39:250A, 1991.

15. Kita H, Abu-Ghazaleh R, Sanderson CJ, Gleich GJ: Effect of steroids on immunoglobulin-

induced eosinophil degranulation. Allergy Digest 5:20, 1991. *16. Ohnishi T, Kita H, Mayeno A, Sur S, Gleich GJ: Eosinophil-active cytokines and an inhibitor of

cytokine activity in the bronchoalveolar lavage fluids (BALF) of symptomatic patients with asthma. J Allergy Clin Immunol. 89:214, 1992.

*17. Ide M, Okubo Y, Kita H, Weiler DA, Gleich GJ: Measurement of eosinophil viability: Comparison

of the MTT assay and fluorescent microscopy. J Allergy Clin Immunol. 89:311, 1992. 18. Kita H, Ohnishi T, Okubo Y, Weiler DA, Abrams JS, Gleich GJ: GM-CSF and IL-3 release from

human peripheral blood eosinophils. J Allergy Clin Immunol. 89:311, 1992. 19. Kita H, Horie S, Okubo Y, Weiler D, Gleich GJ: Pharmacologic modulation of eosinophil

degranulation. J Allergy Clin Immunol. 91:332, 1993. *20. Horie S, Gleich GJ, Weiler DA, Kita H: Regulation of eosinophil degranulation by cytokines and

lipid mediators. J Allergy Clin Immunol. 91:333, 1993. *21. Ide M, Weiler DA, Kita H, Gleich GJ: Eosinophil purification: Comparison of magnetic cell sorting

and Percoll density gradient centrifugation. J Allergy Clin Immunol. 91:334, 1993. 22. Weiler D, Kita H, Okubo Y, Ide M, Gleich GJ: Hypereosinophilic syndrome, toxic oil syndrome

and eosinophilia-myalgia syndrome: Hypodense eosinophils and cytokines. J Allergy Clin Immunol. 91:175, 1993.

*23. Ohnishi T, Weiler D, Mayeno A, Kita H, Gleich GJ: An inhibitory serum factor for eosinophil

active cytokines: Association with siliconized tubes from one company. J Allergy Clin Immunol. 91:158, 1993.

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24. Sedgwick JB, Ohnishi T, Kita H, Gleich GJ, Calhoun WJ, Jarjour N, Busse WW: Comparison of

segmental bronchoprovocation (SBP) with allergen (AG) of asthma and allergic patients: 48 HR eosinophil (EOS) and cytokine response. J Allergy Clin Immunol. 91:237, 1993.

*25. Chen K-R, Pittelkow MR, Kita H, Gleich GJ, Leiferman KM: Cytotoxicity of eosinophil granule

proteins to endothelial cells. J Invest Dermatol. 100:257, 1993. 26. Kita H, Sur S, Gleich GJ: Autocrine activation of eosinophils by eosinophil granule proteins. J

Immunol. 150:145A, 1993. 27. Chen K-R, Kita H, Pittelkow MR, Gleich GJ, Leiferman KM. Eosinophil-mediated vasculitis in

connective tissue disease. J Invest Dermatol. 101:421, 1993. *28. Horie S, Gleich GJ, Kita H: Mac-1 (CD11b/CD18) mediates degranulation of human eosinophils

induced by GM-CSF and PAF. J Allergy Clin Immunol. 93:268, 1994. 29. Kita H, Horie S, Gleich GJ: Laminin and fibronectin inhibit adhesion and degranulation of

eosinophils. J Allergy Clin Immunol. 93:212, 1994. *30. Kaneko M, Swanson M, Gleich GJ, Kita H: Antigen-specific IgG1 induces eosinophil-derived

(EDN) release from eosinophils in bronchial asthma. J Allergy Clin Immunol. 93:212, 1994. *31. Hagan J, Bartemes K, Kita H, Ottesen E, Awadzi K, Nutman T, Gleich GJ: Eosinophil viability

enhancing activity preceding the posttreatment eosinophilia in onchocerciasis. J Allergy Clin Immunol. 93:195, 1994.

*32. Martin LB, Gleich GJ, Swanson MC, Kita H: Normal human peripheral blood mononuclear cells

produce interleukin 5 following in vitro stimulation with interleukin 2. J Allergy Clin Immunol. 93:188, 1994.

33. Sur S, Gleich GJ, Weiler DA, Sarkar G, Kita H, Hunt LW: Eosinophil recruitment after pulmonary

allergen challenge in patients with asthma is specifically associated with upregulation of IL-5 mRNA expression. Am J Respir Crit Care Med. 149:A835, 1994.

34. Kita H, Sur S, Hunt LW, Edel ES, Weiler DA, Swanson M, Ramsel R, Abrams JS, Gleich GJ:

Localized cytokine production and functional modulation of eosinophils in eosinophilic pneumonitis. Am J Respir Crit Care Med. 149:A515, 1994.

*35. Martin LB, Gleich GJ, Kita H: T-lymphocyte enriched peripheral blood mononuclear cells respond

to interleukin 2 stimulation by producing interleukin 5. FASEB J. 8:A226, 1994. *36. Horie S, Gleich GJ, Kita H: Transforming growth factor beta induces the cell death of eosinophils.

FASEB J. 8:A980, 1994 *37. Kato M, Abraham RT, Gleich GJ, Kita H: Role of tyrosine kinases in human eosinophil

degranulation. FASEB J. 8:A469, 1994. *38. Kaneko M, Weiler D, Swanson M, Gleich GJ, Kita H: Antigen-dependent release of TNF- from

PBMC augments eosinophil degranulation in vitro. FASEB J. 8:A980, 1994.

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*39. Nakajima H, Loegering DA, Kita H, Gleich GJ: Reactivity of monoclonal antibodies EG1 and EG2

with eosinophils and their granule proteins. FASEB J. 8:A979, 1994. *40. Nakajima H, Gleich GJ, Kita H: Cytokine gene expression and protein synthesis from eosinophils

stimulated by immunoglobulin (Ig). J Allergy Clin Immunol. 95:342, 1995. *41. Kato M, Abraham RT, Gleich GJ, Kita H: Enhanced phosphoinositide turnover and protein

tyrosine phosphorylation in adherent eosinophils. J Allergy Clin Immunol. 95:340, 1995. *42. Kaneko M, Jarjour NN, Swanson M, Busse WW, Gleich GJ, Kita H: Allergen-specific IgG and

IgA in bronchoalveolar lavage (BAL) fluids from patients with allergy induce eosinophil degranulation. J Allergy Clin Immunol. 95:339, 1995.

43. Kita H, Kaneko M, Frigas E, Bartemes KR, Weiler DA, Gleich GJ: Eosinophils from hay fever

patients degranulate in response to IgG, but not to IgE. J Allergy Clin Immunol. 95:339, 1995. *44. Kaneko M, Horie S, Kato M, Gleich GJ, Kita H: IgG-induced eosinophil degranulation is

dependent on cellular adhesion through CD11b/18. Am J Respir Crit Care Med. 151:A218, 1995. 45. Nagata M, Sedgwick JB, Kita H, Busse WW: Adhesion to VCAM-1 and exposure to GM-CSF

synergistically activate eosinophil (EOS) superoxide anion (O2-) generation and degranulation.

Am J Respir Crit Care Med. 151:A240, 1995. 46. Kita H, Kaneko M, Jarjour NN, Swanson, M, Busse WW, Gleich GJ: Allergen-specific IgG in sera

and bronchoalveolar lavage (BAL) fluids from patients with allergy induce eosinophil degranulation. AAAI/ATS Conference, July 15-17, 1995, Chicago, IL.

*47. Kaneko M, Schimming AW, Bartemes KR, Gleich GJ, Kita H: Mast cells are not playing a role in

eosinophil accumulation induced by allergen in vivo. J Allergy Clin Immunol. 97:281, 1996. 48. Kita H, Weiler DA, Bartemes KR, Abrams JS, Gleich GJ: Spontaneous survival of eosinophils

and IL-5 levels in patients with idiopathic hypereosinophilic syndrome (HES). J Allergy Clin Immunol. 97:271, 1996.

*49. Kim J-T, Gleich GJ, Kita H: Cross-linking of CD9 induces degranulation, GM-CSF production and

survival of human eosinophils. J Allergy Clin Immunol. 97:272, 1996. *50. Nakajima H, Gleich GJ, Kita H: Eosinophils express and produce IL-4, IL-8, and IL-10 - Evidence

for stored and newly synthesized cytokine. J Allergy Clin Immunol. 97:357, 1996. 51. Ohashi H, Ishikawa M, Kita H, Gleich GJ, Kawai H, Osawa T: Effects of protein kinase inhibitors

on eosinophil degranulation induced by secretory IgA (sIgA) conjugated Sepharose beads. J Allergy Clin Immunol. 97:271, 1996.

52. Nagata M, Sedgwick JB, Kita H, Busse WW: Eosinophil (Eos) interaction with ICAM-1 promotes

release of superoxide anion (O2-), Eos-derived neurotoxin (EDN) and LTC4. J Allergy Clin

Immunol. 97:273, 1996.

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*53. Kato M, Abraham RT, Gleich GJ, Kita H: Cross-linking and clustering of Mac-1 (M2) molecules induces activation and degranulation of human eosinophils. Am J Respir Crit Care Med 153:A58, 1996.

*54. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM: Mechanisms of eosinophil transmigration

through basement membrane components in vitro. Am J Respir Crit Care Med. 153:A55, 1996. 55. Levy AM, Kita H, Sandborn WJ, Phillips SF, Gleich GJ: Eosinophil granule protein concentrations

in serum, urine and stool as indicators of disease activity in eosinophilic gastroenteritis. Gastroenterology 110:A950, 1996.

*56. Levy AM, Dubravec V, Kita H, Dyer D, Schkade PA, Phillips SF, Gleich GJ: Daily ingestion of

shiitake mushrooms is associated with eosinophilia, elevated serum IL-5 levels, increased stool eosinophil granule proteins and gastrointestinal symptoms. Gastroenterology 110:A949, 1996.

57. Ohashi H, Takei M, Kita H, Gleich GJ, Fukamachi H: Signal transduction induced by PAF, IL-5

and secretory IgA conjugated to Sepharose beads (sIgA) in cultured eosinophils. J Allergy Clin Immunol. 99:S356, 1997.

*58. Kato M, Kimura H, Tachibana A, Tokuyama K, Morikawa A, Kita H: Activation of dual signaling

pathways by platelet activating factor (PAF) in human eosinophils. J Allergy Clin Immunol. 99:S136, 1997.

59. Dunnette SL, Kita H, Reed CE, Gleich GJ: Topical glucocorticoid treatment of ragweed hay fever.

II. Relationship of eosinophil-derived neurotoxin (EDN) and IL-5 to disease severity. J Allergy Clin Immunol. 99:S124, 1997.

*60. Kim J-T, Gleich GJ, Kita H: Bidirectional regulation of eosinophil survival and apoptosis of FcR.

J Allergy Clin Immunol. 99:S355, 1997. *61. Motegi Y, Gleich GJ, Kita H: Eosinophils, but not neutrophils, are preferentially activated by

secretory IgA (sIgA) compared to serum IgA: Potential roles of secretory components (SC). J Allergy Clin Immunol. 99:S120, 1997.

*62. Schimming A, Gleich GJ, Kita H: Inhibition of eosinophil infiltration into peritoneal cavities of

allergen-challenged mice by lipopolysaccharide (LPS). J Allergy Clin Immunol. 99:S359, 1997. *63. Passe A, Schimming A, Gleich GJ, Hamann KJ, Kita H: Tissue matrix glycosaminoglycan,

heparan sulfate (HS), enhances survival of eosinophils. J Allergy Clin Immunol. 99:S120, 1997. *64. Jorgensen RK, Gleich GJ, Kita H, Reed CE: Topical glucocorticoid treatment of ragweed hay

fever. I. Effects on IgE and IgA antibody production. J Allergy Clin Immunol. 99:S360, 1997. 65. Dubravec VA, Dyer PD, Schkade PA, Kita H, Gleich GJ, Levy AM: Shiitake mushroom induced

eosinophilia: case report and pilot study. J Allergy Clin Immunol. 99:S194, 1997. *66. Bartemes KR, Gleich GJ, Kita H: Autocrine production of platelet-activating factor plays critical

roles in adhesion and effector functions of eosinophils stimulated by immunoglobulins and IL-5. Am J Respir Crit Care Med. 155:A59, 1997.

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*67. Motegi Y, Kita H: Platelet-activating factor activates dual signaling pathways in human eosinophils. J Allergy Clin Immunol. 101:S175, 1998.

*68. Volcheck GW, Gleich GJ, Kita H: Pro- and anti-inflammatory effects of beta adrenergic agonists

on eosinophil response to IL-5. J Allergy Clin Immunol. 101:S35, 1998. 69. Bankers-Fulbright JL, Kephart GM, Loegering DA, Bradford AL, Okada S, Kita H, Gleich GJ:

Sulfonylureas inhibit the survival and activation of human eosinophils in vitro. Am J Respir Crit Care Med. 157:A522, 1998.

*70. Yamazaki K, Lindor KD, Batts KP, Suzuki K, Sato S, Kita H, Gleich GJ: Ursodeoxycholic acid

inhibits eosinophil degranulation in situ in primary biliary cirrhosis. Hepatology 28:542A, 1998. *71. Yamazaki K, Gleich GJ, Kita H: Bile acids activate eosinophils in vitro. Hepatology 28:542A,

1998. *72. Hiraguri M, Kita H: Common and distinct activation mechanisms in eosinophils stimulated with IL-

5 and platelet-activating factor (PAF). J Allergy Clin Immunol. 103:S56, 1999. *73. Kobayashi H, Kita H: Production, storage and release of nerve growth factors by human

eosinophils. J Allergy Clin Immunol. 103:S182, 1999. *74. Kato M, Morikawa A, Kita H: Ligation of the β2 integrin triggers phosphorylation and

degranulation of human eosinophils. J Allergy Clin Immunol. 103:S190, 1999. 75. Bankers-Fulbright JL, Williams MA, Kita H, Gleich GJ, O’Grady SM: Regulation of eosinophil

attack: PKC pla ys a ce ntra l role in superoxide production. Am J Respir Crit Care Med. 159:A465, 1999.

*76. Valyasevi MA, Kita H, Loegering DA, Checkel JL, Gleich GJ: Airway constriction after

intratracheal instillation of human eosinophil granule proteins in mice. Am J Respir Crit Care Med. 159:A34, 1999.

*77. Shimizu T, Kita H: Mucin inhibits eosinophil activation. Am J Respir Crit Care Med. 159:A34,

1999. 78. Hunt LW, Frigas EF, Butterfield JH, Li JT, Patel A, Kita H, Offord KP, Gleich GJ: Nebulized

lidocaine prevents deterioration of pulmonary function following withdrawal of inhaled glucocorticoids. Am J Respir Crit Care Med. 159:A644, 1999.

*79. Muraki M, Gleich GJ, Morrison SL, Kita H: Recombinant antigen-specific IgG and IgA, but not

IgE, induces degranulation and superoxide production by human eosinophils. J Allergy Clin Immunol. 105:S171, 2000.

*80. Shimizu T, Kita H: Activated airway epithelial cells induce migration of eosinophils through

epithelial cell monolayer. J Allergy Clin Immunol. 105:S256, 2000. *81. Iijima K, Bartemes KR, Kita H: Differential functional responses of eosinophils and neutrophils

adherent to intercellular adhesion molecule (ICAM)-1. Am J Respir Crit Care Med. 161: A611, 2000.

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82. Liu LY, Coe CL, Swanson CA, Kita H, Busse WW: Effect of psychological stress on airway

inflammation following antigen (Ag) challenge. Am J Respir Crit Care Med. 161:A771, 2000. *83. Bartemes KR, Iijima K, Kita H: Contrasting adhesion and functional response to ICAM-1 by

eosinophils and neutrophils in vitro. FASEB J. 14:A1141, 2000. 84. Bankers-Fulbright JL, Kita H, Gleich GJ, O'Grady SM: PKC plays a central role in eosinophil

NADPH oxidase regulation. FASEB J. 14:A1240, 2000. *85. Shin S-H, Gleich GJ, Kita H: Abnormal immunologic responses to fungal antigens in patients

with chronic rhinosinusitis. J Allergy Clin Immunol. 107:S163, 2001. *86. Shimizu T, Kita H: Anti-inflammatory effects of heparin on human eosinophils. J Allergy Clin

Immunol. 107:S32, 2001. 87. Yunginger JW, Kita H, Jones RT, Saito K, Hefle SL, Taylor SL: Systemic allergic reactions

following ingestion of erythritol-containing foods and beverages. J Allergy Clin Immunol. 107:S269, 2001.

88. Sedgwick JB, Liu LY, Kita H, Busse WW: 7-Transmembrane receptor (7-TMR) chemokines

activate eosinophil (Eos) degranulation upon IL-5 priming. J Allergy Clin Immunol. 107:S34, 2001. *89. Miike S, Kita H: Roles of protease and protease-activating receptor (PAR) in activation of human

eosinophils. Am J Respir Crit Care Med. 163:A320, 2001. *90. Matsuura T, Adolphson C, Squillace D, Kita H, Gleich GJ: The effect of dexamethasone on

development of eosinophils from umbilical cord blood mononuclear cells. Am J Respir Crit Care Med. 163:A323, 2001.

91. Sedgwick JB, Jansen KJ, Kita H, Busse WW: IL-5-dependent activation of eosinophil

degranulation by 7-transmembrane receptor chemokine. Am J Respir Crit Care Med. 163:A989, 2001.

92. Bankers-Fulbright JL, Gleich GJ, Kita H, O’Grady SM: NADPH oxidase-associated proton

currents regulate granulocyte depolarization independently of superoxide production. FASEB J. 15:A844, 2001.

*93. Inoue Y, Shin S-H, Ponikau J, Kita H: The fungus, Alternaria, induces activation and

degranulation of human eosinophils. J Allergy Clin Immunol. 107:S165, 2002. *94. Bartemes KR, Cooper K, Kita H: Enhanced survival and multiple gene expression in human

eosinophils exposed to soluble secretory IgA. J Allergy Clin Immunol. 107:S230, 2002. *95. Kobayashi T, Iijima K, Kita H: Potential anti-inflammatory role of mouse eosinophils. J Allergy

Clin Immunol. 107:S165, 2002. 96. Sedgwick JB, Jansen KJ, Kita H, Bartemes KR, Busse WW: Increased total cellular eosinophil-

derived neurotoxin (EDN) in eosinophils (Eos) from patients with allergic asthma (AA). J Allergy Clin Immunol. 107:S227, 2002.

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97. Cook EB, Stahl JL, Sedgwick JB, Jansen KJ, Kita H, Graziano F, Barney NP: Anti-IgE activated

conjunctival mast cells mediate upregulation of eosinophil adhesion to conjunctival epithelial cells and eosinophil degranulation. J Allergy Clin Immunol. 107:S248, 2002.

98. Moro MH, Checkel JL, Ovyanikova IG, Kita H, Gleich GJ: Cathepsin B is required for maturation

of eosinophil major basic protein. FASEB J. 16:A1238, 2002. *99. Muraki M, Tohda Y, Fukuoka M, Nakajima S, Kita H, Gleich GJ: Effect of dexamethasone on

eosinophilopoiesis from human umbilical cord blood mononuclear cells stimulated by IL-5. Int Arc Allergy Immunol. 128 (Suppl. 1):25, 2002.

*100. Matsuura T, Bartemes KR, Squillace DL, Gleich GJ, Kita H: Surface expression of eosinophil

major basic protein (MBP) and eosinophil peroxidase (EPO), without apparent extracellular release, by activated human eosinophils. J Allergy Clin Immunol. 111:S259, 2003.

*101. Kim CK, Kim SW, Kim YK, Kita H, Koh YY: Eosinophil cationic protein (ECP) and interleukin (IL)-

8 levels in bronchoalveolar lavage (BAL) from pediatric patients with acute asthma and acute bronchiolitis. J Allergy Clin Immunol. 111:S298, 2003.

*102. Terada A, Iijima K, Kita H: CD9 physically associate with CD11b/CD18 integrin and regulates

adhesion and activation of human eosinophils. J Allergy Clin Immunol. 111:S222, 2003. *103. Inoue Y, Shin SH, Ponikau JU, Kita H: Novel calcium-dependent pathways in eosinophil

interaction with secretory product(s) of the fungus Alternaria. J Allergy Clin Immunol. 111:S258, 2003.

*104. Iijima K, Kobayashi T, Kita H: NK cell-dependent, airway-specific, innate eosinophilic response to

Alternaria in mice. J Allergy Clin Immunol. 111:S199, 2003. 105. Ponikau JU, Kephart GM, Kita H: Extensive degranulation of eosinophils in mucin, but not in the

tissue, of chronic rhinosinusitis patients. J Allergy Clin Immunol. 111:S125, 2003. 106. Stahl JL, Cook EB, Sedgwick JB, Kita H, Barney NP, Graziano FM: Olopatadine inhibits

conjunctival mast cell-mediated and fMLP stimulated eosinophil degranulation but not mast cell-mediated adhesion of IL-5 primed eosinophils. J Allergy Clin Immunol. 111:S117, 2003.

107. Lim KG, Kita H, Sherris D, Moore E, Patel A: Mechanism of cough in post-nasal drip. Am J

Respir Crit Care Med. 167:A219, 2003. *108. Kim CK, Hagan JB, Kita H: Eosinophilic airway inflammation as an underlying mechanism in

certain patients with chronic cough but without asthma. Am J Respir Crit Care Med. 167:A633, 2003.

109. Juhn YJ, Kita H, DeBolt MF, Poland GA, Pankratz SV, Jacobson RM. Assessment of the

association between measles vaccine response and asthma status. J Allergy Clin Immunol. 113:S49, 2004.

77

110. Sedgwick JB, Bartemes K, Kita H, Busse WW. Relationship of in vitro survival and eosinophil derived neurotoxin (EDN) degranulation in blood and airway eosinophils (EOS) following segmental bronchoprovocation with allergen (SBP-AG). J Allergy Clin Immunol. 113:S166, 2004.

*111. Terada A, Kita H. Regulatory role of the carcinoembryonic antigen (CEA)-family molecules in the

innate eosinophil response to Staphylococcus aureus. J Allergy Clin Immunol. 113:S167, 2004. *112. Kobayashi T, Iijima K, Kita H. Beneficial effects of eosinophils in colitis induced by dextran

sulfate sodium. J Allergy Clin Immunol. 113:S172, 2004. 113. Brooks AM, Sedgwick JB, Jansen KJ, Kita H, Squillace D, Kennedy D, Busse WW. VLA-4

antagonist WAY160103 (WAY) inhibits VCAM-1 activated eosinophil (EOS) respiratory burst but promote eosinophil derived neurotoxin (EDN) degranulation. J Allergy Clin Immunol. 113:S324, 2004.

114. Sherris DA, Ponikau JU, Weaver A, Frigas E, Kita H. Treatment of chronic rhinosinusitis with

intranasal Amphotericin B: A prospective, randomized, placebo-controlled trial. J Allergy Clin Immunol. 113:S331, 2004.

115. Davis LJB, Ponikau J, Sherris DA, Plager DA, Kita H. Gene microarray analysis of CD4-positive

T cells in chronic rhinosinusitis (CRS). J Allergy Clin Immunol. 113:S332, 2004. *116. Hagan JB, Frigas E, Wendland BI, Hanson CA, Severson RJ, Harris PA, Kim CK, Hunt LW, Kita

H. Reference values for induced whole sputum performed in a routine clinical laboratory. Am J Respir Crit Care Med. 169:A516, 2004.

*117. Kim CK, Volcheck GW, Kita H. Increase in airway eosinophilia and a Th1 cytokine during the

chronic asymptomatic phase in patients with asthma. Am J Respir Crit Care Med. 169:A804, 2004.

*118. Shin SH, Ponikau JU, Sherris DA, Congdon D, Frigas E, Homburger HA, Swanson MC, Gleich

GJ, Kita H. Chronic rhinosinusitis: an exaggerated immune response to ubiquitous airborne fungi. Clin Invest Med. 27:121A, 2004.

119. Rajagopala G, Iijima K, Kita H, David CS. Exposure to bacterial superantigen induces

eosinophilic airway inflammation and airway hyperreactivity in HLA class II transgenic mice. Clin Invest Med. 27:132A, 2004.

120. Radhakrishnan S, Iijima K, T Kobayashi, H Kita. M Rodriguez, LR Pease. Blockade of allergic

airway disease following systemic treatment with a B7-DC (PD-L2) crosslinking human antibody. Clin Invest Med. 27:39C, 2004.

*121. Kobayashi T, Iijima K, H Kita. Beneficial effects of eosinophils in colitis induced by dextran

sulfate sodium. Clin Invest Med. 27:100D, 2004. *122. Yamazaki K, Volcheck GW, Kita H: Allergen-induced immune responses in non-allergic asthma.

J Allergy Clin Immunol. 115:S70, 2005. *123. Matesic D, Frigas E, Kita H, Harris PA, Volcheck GW, Markus PA, Weiler CR, Maddox DE, Li

LTC, Van Dellen RG, Hagan JB, Butterfield JH: Comparison of an in-house preparation of the

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major allergenic determinant of benzyl penicillin G with the commercially produced Pre-Pen. J Allergy Clin Immunol. 115:S182, 2005.

*124. Matsuwaki Y, Inoue Y, Kita H: Fungal antigens from Alternaria stimulate activation and

degranulation of human eosinophils through a Gi-coupled PAF receptor. J Allergy Clin Immunol. 115:S191, 2005.

125. Volcheck GW, Harris PA, Kita H, Richardson DM, Davis MDP, Scroeter AL, Frigas E. Pilot study

of delayed hypersensitivity testing with fungal allergens in patients with allergic rhinitis and chronic rhinosinusitis. J Allergy Clin Immunol. 115:S196, 2005.

*126. Methta V, Kobayashi T, Kita H: Effects of fungal antigen exposure on airway allergen

sensitization. J Allergy Clin Immunol. 115:S221, 2005. 127. Hagan JB, Kita H, Mehta: Sinus CT findings associated with sputum eosinophilia. Proceedings of

the American Thoracic Society. 2:A341, 2005. 128. Barnes TW, Kroening PR, Kita H, Vassallo R: Cigarette smoke extract impairs CD40 ligand-

induced maturation of human dendritic cells. Clin Immunol. (Suppl 1):S72. 2005. *129. White TA, Matsuwaki Y, Kita H: A role for ectoenzyme, CD38, in human eosinophil function. J

Allergy Clin Immunol. 117:S61, 2006. *130. Molis WE, Kita H, Lee LA, Maki RJ, Smith R, Chang T, Weaver A, Pankratz V, Jacobson RM,

Poland GA, Juhn YJ: Timelines of diagnosis of asthma in children with associated factors. J Allergy Clin Immunol. 117:S99, 2006.

*131. Kobayashi T, Iijima K, Radhakrishman S, Mehta V, Vassallo R, Pease LR, Kita H: Innate immune

response to an environmental fungus, Alternaria, facilitates Th2-type airway sensitization to a bystander antigen. J Allergy Clin Immunol. 117:S188, 2006.

*132. Matsuwaki Y, Thomas W, Hotta K, Kita H: Exogeneous chitinase activate and induce

degranulation of human eosinophils through a protease-activated receptor-2 (PAR-2). J Allergy Clin Immunol. 117:S189, 2006.

133. Frigas E, Markus PJ, Narr BJ, Danielson DR, Park PA, Bachman KA, Harris PA, O’Byrne MM,

Koos KE, Volcheck GW, Kita H, Shroeder DR. Allergy consultation and skin testing benefits significantly the selection of the antibiotic for antibacterial prophylaxis preoperative (ABPPO) in patients who report allergy to penicillin (PRAP). J Allergy Clin Immunol. 117:S225, 2006.

*134. Terada A, Kita H: Eosinophils produce an innate immune response to staphylococcus aureus

through recognition of peptidoglycan. J Allergy Clin Immunol. 117:S269, 2006. 135. Plager DA, Henke SA, Matsuwaki Y, Madaan A, Squillace DL, Diekhising RA, Parneix Sparke A, Kita H: Pimecrolimus reduces calcium-dependent eosinophil activation. J Invest Dertmatol. 126(4 Suppl):44, 2006. *136. Yoon J, Kita H. Lipid rafts are essential for IL-5 activation of human eosinophils. J Immunol. 176(Suppl):S25, 2006.

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137. Hagan JB, Taylor RL, Kita H, Singh RJ. Analysis of Fluticasone Propionate in Induced Sputum by Mass Spectrometry. Am J Respir Crit Care Med. 175:A318, 2007.

138. O'Grady SM, Bankers-Fulbright J, Bartemes K, Kephart G, Kita H. Substrate-induced eosinophil

adhesion requires intracellular Ca2+ mobilization and PI-3 kinase activation. FASEB J. 21:A1153, 2007.

139. Frigas E, Park MA, Matesic D, Bachman KA, Volcheck GW, Gustafson RO, Friedman O,

Pallanch JF, Lane JI, Welker KM, Severson RJ, Butterfield JH, Hagan JB, Li JT, Schroeder DR, Kita H. A pilot, prospective, double blind, placebo-controlled treatment trial with Itraconazole orally in patients with chronic rhinosinusitis and asthma. J Allergy Clin Immunol. 119:S142, 2007.

140. Kung AY, Kita H, Guarderas JC, Gustafson RO, Park M. Oral itraconazole in the treatment of

chronic rhinosinusitis. J Allergy Clin Immunol. 119:S302, 2007. *141. Kobayashi T, Radhakrishnan S, Pease LR, Kita H. An environmental fungus, Alternaria,

stimulate OX40L and CDR7 expression by dendritic cells. J Allergy Clin Immunol. 119:S48, 2007. *142. Matsuwaki Y, White T, Hotta K, Inoue Y, Lawrence CB, Kita H. Aspartate protease from

Alternaria induces cytokine production, and calcium signaling in human airway epithelial cells through a protease-activated receptor-2 (PAR-2). J Allergy Clin Immunol. 119:S137, 2007.

*143. Wada K, Matsuwaki Y, Bingemann TA, Kita H. Cockroach activates and induces degranulation

of human eosinophils through protease-activated receptor-2 (PAR2). J Allergy Clin Immunol. 119:S215, 2007.

*144. Bartemes KR, Kita H. IL-25 induces type 2 immune responses by lineage-negative

undifferentiated cells. J Allergy Clin Immunol. 121:S118, 2008. *145. Cherry WB, Yoon J, Kita H. A novel IL-1 family cytokine, IL-33, activates and enhances survival

of human eosinophils. J Allergy Clin Immunol. 121:S150, 2008. *146. Dave SA, Yoon J, Wada K, Kobayashi T, Naseri M, Kita H. A mite antigen, Der p1, activates

dendritic cells (CDs) and Stimulates Th2 polarization through a toll-like receptor (TLR)-4 pathway. J Allergy Clin Immunol. 121:S198, 2008.

*147. Dhillon RK, Kita H, Yawn BP, Mc Gree ME, Weaver AL, Yoo KH, Wollan P, Boyce TG, Jacobson

RM, Juhn YJ. Impact of asthma on the severity of invasive pneumococcal disease. J Allergy Clin Immunol. 121:S23, 2008.

*148. Iijima K, Kobayashi T, Bartemes KR, Kita H. Airway NK cells are involved in innate Th2-like

inflammation. J Allergy Clin Immunol. 121:S255, 2008. 149. Jung JA, Kita H, Yawn BP, Mc Gree ME, Weaver AL, Yoo KH, Wollan P, Boyce TG, Jacobson

RM, Juhn YJ. Increased risk of invasive pneumococcal disease in atopic patients. J Allergy Clin Immunol. 121:S31, 2008.

*150. Kato M, Ishioka T, Kita H, Hoshino H, Kozawa K, Kimura H. Major basic protein enhances GM-

CSF and IL-17 production, and apoptosis in bronchial epithelial cells, A549 infected with respiratory syncytial virus. J Allergy Clin Immunol. 121:S46, 2008.

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*151. Kephart G, Alexander J, Aroral A, Romero Y, Smyrk T, Talley N, Kita H. Localization of

eosinophil-derived neurotoxin in Esophageal tissues: A potential biomarker for eosinophilic Esophagitis. J Allergy Clin Immunol. 121:S44-45, 2008.

*152. Kobayashi T, Iijima K, Kita H. An environmental fungus, alternaria, facilitates th2-type airway

sensitization idependently of TLR2 and TLR4. J Allergy Clin Immunol. 121:S199, 2008. 153. Kung AY, Kita H, Yawn BP, McGree ME, Weaver AL, Yoo KH, Wollan PH, Boyce TG, Jacobson

RM, Juhn YJ. The ecological relationship between the trends of asthma and invasive pneumococcal disease in Rochester, Minnesota. J Allergy Clin Immunol. 121:S160-161, 2008.

*154. Straumann A, Conus S, Kita H, Kephart G, Bussmann C, Beglinger C, Patel J, Byrne M, Simon

HU. Mepolizumab, a humanized monoclonal antibody to IL-5, for severe eosinophilic Esophagitis in adults: A randomized, placebo-controlled double-blind trial. J Allergy Clin Immunol. 121:S44, 2008.

*155. Weiler CR, Squillace D, Kephart G, Romero Y, Alexander J, Kita H. Eosinophil degranulation,

gastric eosinophil-derived neurotoxin (gEDN) levels and dysphagia score in patients with eosinophilic Esophagitis (EE). J Allergy Clin Immunol. 121:S44, 2008.

156. Hagan JB, Sykes AG, Kita H, Bartholmai BJ. Peripheral airway thickening in asthma is

associated with age, male gender, blood leukocyte and sputum eosinophilia. Am J Respir Crit Care Med. 177:A563, 2008.

157. Alexander J, Kephart G, Ravi K, Neumann D, Kita H, Talley N. Is immunofluoresence staining for

eosinophil derived neurotoxin useful in the diagnosis of eosinophilic esophagitis? Am J Gastroenterol. 103:S27, 2008.

158. Jung JA, Kita H, Mann R, Tsigrelis C, Baddour LM, Jacobson RM, Boyce TJ, Juhn YJ.

Assessment of the influence of asthma status on serotype-specific antibody response to pneumococcal polysaccharide antigens. J Allergy Clin Immunol. 123:S82, 2009.

*159. Karakelides M, Iijima K, Checkel JL, Kobayashi T, Kita H. Airway exposure to papain, a cysteine

protease, induces allergic inflammation. J Allergy Clin Immunol. 123:S49, 2009. *160. Kobayashi T, Iijima K, Checkel JL, Kita H. Eosinophils are not involved in the sensitization phase

of allergic responses. J Allergy Clin Immunol. 123:S269, 2009. *161. Kobayashi T, Kita H. An endogenous danger signal, uric acid, attracts and activates human

eosinophils. J Allergy Clin Immunol. 123:S252, 2009. *162. Kouzaki H, O’Grady SM, Kita H. Airway epithelial cells recognize protease activities in allergens

and produce thymic stromal lymphopoietin (TSLP). J Allergy Clin Immunol. 123:S74, 2009. *163. Matsuwaki Y, Lawrence CB, Kita H. An exogenous glycosidase, sylanase, induces human

eosinophil degranulation through protease-activated receptor-2 (PAR-2). J Allergy Clin Immunol. 123:S270, 2009.

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*164. Rank MA, Kobayashi T, Bartemes KR, Kita H. Activation of dendritic cells by IL-33 initiates a Th2 response. J Allergy Clin Immunol. 123:S53, 2009.

165. Rigelman-Hedberg NE, Hettinger AS, Fink LR, Kita H, Jacobson R, Yawn B, Li X, Bailey K, Juhn

YJ. Assessment of susceptibility to pertussis in individuals with atopic conditions other than asthma. J Allergy Clin Immunol. 123:S162, 2009.

166. Yoo KH, Kita H, Jacobson RM, Yawn BP, McGree M, Weaver AL, Juhn YJ. Asthma status and

pneumococcal pneumonia; a population-based case-control study. J Allergy Clin Immunol. 123:S170, 2009.

167. Yun HD, Jung JA, Kita H, Mann R, Tsigrelis C, Baddour LM, Jacobson RM, Boyce TG, Juhn YJ.

Atopic conditions and pneumococcal polysaccharide serotype-specific antibody levels. J Allergy Clin Immunol. 123:S40, 2009.

168. Kita H, Checkel JL, Iijima K, Radhakrishnan S, VanKeulen VP, McClimon J, Kobayashi T, Plager

DA, Pease LR. Allergen-specific IgE, IgG, and Th2-type cytokine responses are effectively downregulated by immunotherapy with the novel dendritic cell (DC)-stimulating antibody, B7-DCXab. J Allergy Clin Immunol. 123:724, 2009.

169. Alexander J, Jung KW, Arora A. Enders F, Francis D, Kita H, Romero Y, Katzka D, Smyrk T,

Talley N. A randomized placebo-controlled trial of swallowed fluticasone as treatment of eosinophilic esophagitis. American J Gastroenterol. 105:58, 2010.

170. Kouzaki H, Iijima K, Kobayashi T, O’Grady S, Kita H. Stressed airway epithelial cells release a

nuclear alarmin IL-33 and Trigger Th2-type immune responses. J Allergy Clin Immunol. 125:AB104, 2010.

171. Kobayashi T, Iijima K, Checkel JL, Kita H. Airway exposure to IL-33 induces IL-5 dominant Th2-

type immune responses to inhaled antigens and asthma-like pathology. J Allergy Clin Immunol. 125:AB108, 2010.

172. Kobayashi T, Uematsu K, Nagata M, Kita H. Autocrine release of ATP plays a pivotal role when

eosinophils degranulate in response to microbial stimuli. J Allergy Clin Immunol. 125:AB183, 2010.

173. Gupta S, Kita H, Collins M, Perschy T, Heath A, Jurgensen C. Utility of eosinophil-derived

neurotoxin as a biomarker in eosinophilic esophagitis: results from a randomized, double-blind, controlled trial of Mepolizumab in pediatric patients. J Allergy Clin Immunol. 125:AB234, 2010.

174. Wada K, Matsuwaki Y, Yoon J, Benson LM, CHeckel JL, Bingemann TA, Kita H. Inflammatory

responses of human eosinophils to cockroach are mediated through protease-dependent pathways. J Allergy Clin Immunol. 126:169-172.e2, 2010.

175. Lee J, Zhao H, Fenta Y, Kita H, Kumar R, Juhn Y. Serum 25-hydroxyvitamin D is positively

associated with enhanced pneumococcal antibody titers in individuals with atopic conditions. J Allergy Clin Immunol. 127:AB98, 2011.

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176. Elias MK, Squillace D, Kita H. Intranasal eosinophilic major basic protein may have a role as a biological marker for chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 127:AB122, 2011.

177. Kobayashi T, Iijima K, Checkel JL, Kita H. IL-4 plays a pivotal role in regulating the development

of Th2 and Th17 responses in the airways. J Allergy Clin Immunol. 127:AB141, 2011. 178. Kouzaki H, Iijima K, Kobayashi T, O’Grady SM, Kita H. The danger signal, extracellular ATP, is a

sensor for airborne allergens and triggers IL-33 release and innate Th2-type responses. J Allergy Clin Immunol. 127:AB124, 2011.

179. Hara K, Iijima K, Kobayashi T, Kephart G, Kita H. IL-33 mediates both innate and adaptive Th2-

type responses induced by proteases in the airway. J Allergy Clin Immunol. 129:AB70, 2012. 180. Iijima K, Kobayashi T, Hara K, Kephart G, Kita H. Roles for IL-33 and TSLP in chronic

eosinophilic airway inflammation induced by airborne allergen exposure. J Allergy Clin Immunol. 129:AB70, 2012.

181. Kato M, Ishioka T, Kita H, Kozawa K, Hayashi Y, Kimura H. Eosinophil granular proteins

specifically major basic protein damage bronchial epithelial cells infected with respiratory syncytial virus J Allergy Clin Immunol. 129:AB116, 2012.

182. Soma T, Kobayashi T, Seno S, Kita H. Extracellular release of endogenous ATP mediates

eosinophila recognition of fungal products and degranulation. J Allergy Clin Immunol. 129:AB117, 2012.

183. Kobayashi T, Iijima K, Kita H. Exposure to IL-1-family cytokines regulates differential

development of antigen-specific Th2 cells and T follicular helper (Tfh) cells in the airway. J Allergy Clin Immunol. 129:AB145, 2012.

184. Kouzaki H, Iijima K, Kobayashi T, O’Grady S, Kita H. Exposure to airborne allergens induces

rapid extracellular release of stored IL-1b from airway epithelial cells. J Allergy Clin Immunol. 129:AB198, 2012.

185. Seno S, Iijima K, O’Grady S, Kita H. Cysteine proteases induce production and extracellular

release of IL-33 in airway epithelial cells. J Allergy Clin Immunol. 129:AB199, 2012. 186. Kephart G, Kita H, Rank M, Katzka D. Can novel histologic biomarkers predict correct diagnosis

and treatment response in patients with matched esophageal eosinophilia. J Allergy Clin Immunol. 2012.

187. Kouzaki H, Tojima I, Kita H, Shimizu T. Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells. J Allergy Clin Immunol. 131:AB190, 2013. 188. Podjasek J, Jung JA, Kita H, Park MA, Juhn YJ. The role of the FACT score in predicting

antibody responses to pneumococcal antigens in asthmatics and nonasthmatics. J Allergy Clin Immunol. 131:AB62, 2013.

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189. Rajagopalan G, Tilahun A, Iijima K, Kita H. Chronic sub-cutaneous exposure to a staphylococcus aureus superantigen, staphylococcal enterotoxin b, elicits an eosinophilic airway inflammation in hla class ii transgenic mice – linking atopic dermatitis to asthma. J Allergy Clin Immunol. 131:AB331, 2013.

190. Samant S, Rank MA, Hagan JB, Kita H. A proposed model to study immunologic changes during

chronic rhinosinusitis exacerbations: data from a pilot study. J Allergy Clin Immunol. 131:AB59, 2013.

191. Rank MA, Kita H, Li JT, Butterfield JH. Systemic reactions to allergen immunotherapy: a role for

measuring a PGD2 metabolite? Ann Allergy Asthma Immunol. 110:57-58, 2013. 193. O’Grady SM, Maniak PJ, Lancto C, Shivappa N, Kita H. Alternaria alternate aeroallergens evoke

atp release and IL-33 secretion from normal and asthmatic bronchial epithelial cells. FASEB J. Apr;27, 2013.

194. Bartemes K, Fox S, Kita H. IL-33 and IL-25-responsive innate lymphoid cells are present in

human peripheral blood. J Immunol. 190:181, 2013.

195. Chen CC, Iijima K, Kobayashi T, Kita H. Differential regulation of type 2 innate lymphoid cells by IL-25 and IL-33. J Immunol. 190:115.23, 2013.

196. Drake L, Kita H. Type 2 innate lymphoid cells promote Th2 cytokine production by CD4+T cells

and antibody responses by B cells. J Immunol. 190:183.3, 2013.

197. Kato M, Ishioka T, Kita H, Kozawa K, Hayashi Y, Kimura H. Major basic protein enhances apoptosis and production of gm-csf and il-17 in bronchial epithelial cells infected with respiratory syncytial virus. Allergy. 68:83-84, 2013.

198. Kobayashi T, Noguchi T, Uchida Y, Soma T, Nakamoto H, Kita H, Nagata M. Uric acid, a danger

signal, activates human eosinophils. Respirology. 18:158, 2013.

199. Samant S, Rank MA, Hagan JB, O’Brien E, Lal D, Kita H. Immunologic changes during chronic rhinosinusitis exacerbations compared to controls. J Allergy Clin Immunol. 133:AB237, 2014.

200. Sun Y, Kita H. Alternaria-induced releases of IL-1 alpha and IL-1 beta from airway epithelial cells

through syk and pkc signaling pathways. J Allergy Clin Immunol. 133:AB245, 2014.

201. Jin J, Alexander J, Kita H, Squillace D, Murray JA, Arora A, Romewro Y, Smyrk T, Weiler CR. Mast cells, eosinophils and eosinophilic esophagitis. J Allergy Clin Immunol. 133:AB287, 2014.

202. Kobayashi T, Iijima K, Kita H. Follicular helper T cells mediate IgE antibody production and

allergic immune responses in mice. J Allergy Clin Immunol. 133:AB292, 2014.

203. Divekar R, Hagan JB, Kita H. Phenotypic classification of allergen polysensitization in geriatric adults. J Allergy Clin Immunol. 133:AB45, 2014.

204. Iijima K, Kobayashi T, Hara K, Kephart G, Kita H. IL-33 and TSLP mediate chronic eosinophilic

airway inflammation and IgE antibody production induced by multiple airborne allergens. J Allergy Clin Immunol. 133:AB49, 2014.

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205. Hara K, Iijima K, Kobayashi T, Seno S, Tojima I, Kephart G, Ueno M, Maeno T, Kurabayashi M,

Kita H. Mucosal uric acid induces interleukin 3 and initiates type 2 immune responses to inhaled protease allergens. J Allergy Clin Immunol. 133:AB50, 2014.

206. Patil N, Maniak P, Kita H, O’Grady S. Aeroallergens derived from alternaria alternate evoke atp

release and chronic increases in intracellular ca2+ in bronchial epithelial cells by a mechanism involving oxidative stress. FASEB J. 28(1), 2014.

207. O’Grady S, Maniak P, Kita H. Exposure of human bronchial epithelial cells to fungal aeroallerens

induces calcium mobilization and anion secretion by a mechanism involving oxidative stress. FASEB J. 28(1), 2014.

208. Hara K, Ueno M, Isobe Z, Maeno T, Kurabayashi M, Kita H. Airway exposure to staphylococcus

aureus particles promotes development of antigen-specific th2-type immunity to inhaled antigens through production of thymic stromal lymphopoietin (tslp). Respirology.19:63, 2014.

209. Divekar RD, O’Brien E, Jin J, Patel NS, Rank MA, Hagan JB, Kita H. Symptom-based clustering

in chronic rhinosinusitis reveals phenotypic heterogeneity. J Allergy Clin Immunol.135:AB55, 2015.

210. Patil N, Maniak P, Kita H, O’Grady S. Aeroallergens derived from alternaria alternate stimulate cox2-dependent expression of antioxidant defense enzymes in human bronchial epithelial cells. FASEB J. 29(1), 2015.

211. Podjasek J, Wi CI, Kita H, Theel E. Juhn YJ. Development and initial testing of whole blood cell

stimulation assay to determine th1 vs. th2 immune profiles. J Allergy Clin Immunol. 135:AB176, 2015.

212. Uno K, Matsuwaki Y, Omur K, Hayashi E, Kita H, Otori N, Kojima H. The roles of type 2 innate

lymphoid cells (ilc2) in chronic rhinosinusitis (crs). J Allergy Clin Immunol. 135:AB54, 2015.

213. Hagan JB, Laidlaw TM, Divekar RD, O’Brien E, Kita H, Volcheck GW, Hagan CR, Lal D, Teaford HG, Erwin PJ, Rank MA. The diagnostic testing accuracy of urinary leukotriene e4 in determining aspirin intolerance in asthma: a systematic review and meta-analysis. J Allergy Clin Immunol. 137:AB390, 2016.

214. Iijima K, Chen CC, Dent AL, Kita H. Follicular helper T (tfh) cells are indispensable for IgE

antibody responses to airborne allergens. J Allergy Clin Immunol. 137:AB1, 2016. 215. Iijima K, Kobayashi T, Uchida M, Anderson EL, Squillace D, Kephart GM, O’Grady SM, Kita H.

Oxidative stress responses to the fungal allergen alternaria mediate IL-33 secretion by airway epithelial cells and type 2 immunity in the airways. J Allergy Clin Immunol. 137:AB199, 2016.

216. Drake, LY. Squillace, D. Iijima, K. Kobayashi, T. Kepbart, G. O'Brien, D. Kita, H. Lung il-33 overexpression does not cause inflammation, but increases allergen sensitivity and

disrupts lung morphogenesis. J Immunol. May 1; 196, 2016. 217. Sasaki, N. Kita, H. Nakamura, Y. Yamauchi, K. Spleen tyrosine kinase and calcium play critical

roles in the release of il-33 from airway epithelial cells exposed to fungus alternaria alternata. Am J Resp Crit Care Med. 193: A1486, 2016.

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Documents

CURRICULUM VITAE/BIBLIOGRAPHY Hirohito Kita, M · 2017-07-04 · 2008 Reviewer for Arthritis Research Campaign (UK) 2012-2015 NIH Study Section Ad Hoc Member (HAI, Hypersensitivity,