1

Curriculum VitaeCheryl Anne Frye

US citizen, Alaska Native (Ketchikan) Sutton Loop, Fairbanks, AK spouse: James Kevin Lembo, RPI class of 1988 kids: Jeffrey, Vincenzo, Luciana Lembo

EDUCATIONWheaton College 1984-1988Biopsychology Department B.A., cum laude, BiopsychologyTufts University 1988-1992Psychology Department M.S., Ph.D., Behavioral NeuroscienceBoston University 1993-1995Biology Department NRSA Post-doc, Neuroendocrinology

PERSONAL STATEMENTMy research program focuses on how novel sources (such as the brain) and targets (GABA, NMDA, dopamine,membrane progestin receptors, stress axis) of steroids influence neuroplasticity, affiliation and cognition.R e w a rd: Biosynthesis of steroids in the ventral tegmental area, hippocampus, nucleus accumbens and frontal cortex is increased with social and cognitive experiences and are attenuated with stressors, such as social isolation. Steroids effects relevant for neuroplasticity and neurocognitive development are investigated.Etiop a thop h y sio l o g y : The role of neurosteroids, sex/gender differences, and/or hormone effects in neuropsychiatric (anxiety, depression, post-traumatic stress disorder) and neurodegenerative (epilepsy, Alzheimer’s Disease, traumatic brain injury, cancer) disorders or aging are investigated through clinical collaborations.T rea t m e n t : How existing drugs, those in development, or non-pharmacological therapies have their indicated and/or side effects in animals or people in part through hormonal, neurosteroid signaling, are investigated.

POSITIONS & EMPLOYMENTThe University of Alaska, Fairbanks, Full Professor of Neuroscience, Director INBRE 2013-presentThe University at Albany, SUNY, Full Professor of Psychology (current leave of absence) 2006-2012The University at Albany, SUNY, Member, Inst for Health & the Environment 2003-presentResearch Experience for Undergraduates Program at UAlbany, Co-Director 2001-2004The University at Albany, SUNY, Associate Professor of Psychology 2000-2006The University at Albany, SUNY, Member, Neuroscience Research Center 1998 -present The University at Albany, SUNY, Adjunct Professor of Biological Sciences 1998-present The University at Albany, SUNY, Assistant Professor of Psychology 1998-2000The University of Hartford, Department of Biology, Adjunct Professor 1998-2000Connecticut College, Assistant Professor of Psychology & Zoology, Director of Neuroscience 1995-1998Wheaton College, Department of Psychology, Visiting Assistant Professor 1994-1995Boston University, Department of Biology, NRSA Post-doctoral Fellow 1993-1995Bates College, Departments of Psychology & Biology, Visiting Assistant Professor 1992-1993Wheelock College, Department of Human Development, Instructor 1990-1992Tufts University, Department of Psychology, TA, RA, Instructor 1988-1992Boston University, Department of Biology, NSF REU Recipient 1987-1988Wheaton College, Department of Psychobiology, Research Assistant 1986-1987Harvard Medical School, Department of Urological Research, Laboratory Technician 1985-1986Harvard Health, Emergency Services, Adult and Pediatric Med, Ortho, Surg Tech. 1982-1995

2

HONORSBoston Latin School Distinguished Graduate Award (former recipients Bernstein, Kennedy, Fiedler) 2009Neurobiology of Learning and Memory, Top Cited Article 2008-2010 2010The University at Albany, SUNY, CAS Dean Student Mentoring Award 2009Albany City Council of PTAs, Founders' Day Award 2008The University at Albany, SUNY, Research Excellence Award 2007Delaware Community School, Volunteer Award 2007Behavioral Brain Research, Top Reviewer 2007The Research Foundation of State University of New York, Promising Inventor Award 2005The Society for Neuroscience, Faculty for Undergraduate Neuroscience, Educator of the Year 2003Wheaton College, Young Alumna Achievement Award 1997

PROFESSIONAL EXPERIENCEGrant R ev iews for United States ( not l is t e d: those for C anada, UK, Fran ce , Sw i tzerland, N e w Z e al a nd, Isra e l ) NIH Special Emphasis Review Panel: Nat. Cooperative Drug Discovery/Development Groups 2013NIH Special Emphasis Program: Estrogen and Sexual Behavior 2013NIH Program Project Review Panel: Development of the Parental Brain 2010-2011NIH Special Emphasis Review Panel: Drug Abuse 2011NIH Review Panel: Biobehavioral Regulation, Learning, and Ethology (ad hoc) 2011Veterans' Affairs: Research Enhancement Program 2010Veterans' Affairs: Traumatic Brain Injury Panel 2010National Institute for Psychobiology in Israel Review Panel 2010NIH Fogarty International Research Collaboration Award Review Panel 2009NIH Review Panel: International and Cooperative Projects - 1 Study Section 2009-2010NIH Review Panel: Research Education Program 2008-2010NIH Review Panel: Fellowships: Brain Disorders and Related Neuroscience 2008-presentNIH Career Opportunities in Research Honors Undergraduate Research Training Panel 2008-2010NIH Special Emphasis Review Panel: Fellowships: Behavioral Neuroscience 2008-2009Alzheimer’s Association Reviews 2006-2010NIH Special Emphasis Review Panel: Minority Undergraduate Biomedical Education Program 2006-2007NIH Special Emphasis Review Panel: The CNS as a Target of Steroid Hormones 2005-2006NIH Special Emphasis Review Panel: Androgens and Aging 2004-2005NIH Special Emphasis Review Panel: Women’s Health Initiative 2004-2005NIH Special Emphasis Review Panel: COBRE 2004-2005NIH Special Emphasis Review Panel: Mechanisms of Stress 2003-2004National Institute of Mental Health, IFCN-4 Study Section (ad hoc) 2003-2004International Steroids & Nervous System Conference, Advisory Board 2002-presentNational Institute of Health, Heart, Lung and Blood Study Section (ad hoc) 2001-2003NIH Special Emphasis Review Panel - Improving Minority Research Opportunities 2000-2001Publi c at i ons R ev iews Editorial Board, Frontiers in Experimental Endocrinology 2011-present Editorial Board, Behavioral Pharmacology 2010-present Editorial Board, Journal of Steroid & Hormonal Science 2010-present Editorial Board, Pharmacology, Biochemistry & Behavior 2008-present Guest Editor, Special Issue, Physiology and Behavior, 50th Year of Estrogen Receptor 2008-2010Guest Editor, Special Issue, Physiology and Behavior, Autism & Androgens 2008-2010Editorial Board, Brain Research 2002-presentEditorial Board, Physiology & Behavior 2001-present

3

S c ienti f ic and E du c at i onal D eve lop m e nt International Congress on Steroids and The Nervous System, Educational Committee 2003-presentInternational Pharmacology, Biochemistry, & Behavior Conference, Fellowships 2003-2008North East Under/graduate Research Organization for Neuroscience, Founder & Director 1996-presentResearch Experience for Undergraduate SUNY Summer Program, Co-Founder & Director 2000-2004Biocontinuum Group (Provides Continuing Medical Education to Neurologists) 2004-2009American Academy of Neurology, Neuroendocrine Section 2000-present

GRANT SUPPORT-ACTIVE

“Alaska INBRE-2: Environmental Agents and Disease” PI: Cheryl A. Frye, Ph.D Total Costs: $3,174,066Dates of Project: 03/01/2013 – 02/28/2014 Annual Dir.: $2,233,006Agency: NIGMS, Type: INBRETo support the development of infrastructure, faculty and trainees to promote biomedical research focused on environmental agents and disease.

“BIOPREP, TIPS, & RAWHIDE”PI: Cheryl A. Frye, Ph.D., co-PI Andre Lopes Total Costs: $3,000,000Dates of Project: 4/1/09-3/31/14 Annual Dir.: $600,000Agency: NIGMS, Type: variousTo support the development of educational pipeline programs to promote STEM among K-12 students.

“Progestins’ non-classical effects and mechanisms for social & mood processes”PI: Cheryl A. Frye, Ph.D. Total Costs: $1,287,752Dates of Project: 08/15/10-5/31/14 Annual Dir.: $212,500Agency: NIMH, Type: R01To elucidate the role and mechanisms of progestogens via signaling of the pregnane xenobiotic receptor to mediate responses to stressors.

"Is estrogen receptor β a target for beneficial effects of androgens in an animal model of andropause?"P.I. Cheryl A. Frye, Ph.D. Total Costs: $103,330Dates of Proposed Project: 9/1/10-8/31/13 Annual Direct: $34,102Agency: Karo Bio Type: Drug ContractTo investigate ERβ’s actions for trophic effects in brain and prostate.

“Exploratory center on minority health and health disparities in smaller cities- Environmental contaminants and reproductive health of Akwesasne Mohawk women”PI: Lawrence Schell, Ph.D.; Consultant/Collaborator: Frye Annual: $96,248 Dates of Project: 4/1/09-3/31/14Agency: NIH, Type: P20To measure daily levels of salivary estrogen and progesterone over the menstrual cycle as a measure of reproductive endocrine function among Native people exposed to endocrine disruptors.

4

PRIOR EXTRAMURAL SUPPORT

“The role of membrane progestin receptors in progestin-facilitated lordosis”PI: Cheryl A. Frye, Ph.D.; Total Costs: $106,000Dates of Project: 12/01/09-12/31/12; Annual Direct: $66,007Agency: NSF, Type: EAGERTo investigate the role of membrane progestin receptors versus nuclear progestin receptors in progesterone signaling.

“Neuroactive steroids and seizure control during pregnancy in women with epilepsy”PI: Page Pennell, MD; Co-PI: Cheryl A. Frye, Ph.D.; Total Costs: $51,740Dates of Project: 7/1/09-8/31/12; Annual Direct: $14,776Agency: Brigham and Women’s Hospital/NIH, Type: R03To measure levels of progestogens in samples collected from pregnant women on neuromodulatory medications.

“A drug contract to investigate depression-like behavior of a proprietary estrogen-like compound”PI: Cheryl A. Frye, Ph.D.; Total Costs: $39,900Dates of Project: 09/01/10-12/12/12; Annual Direct: $25,000Agency: Karo Bio Type: Drug ContractTo examine the effects of a proprietary estrogen -like compounds to improve hormone replacement therapies.

“Progestins non-classical effects and mechanisms for social & mood processes”PI: Cheryl A. Frye, Ph.D.; Total Costs: $378,750Dates of Project: 09/14/09-09/13/10; Annual Direct: $250,000Agency: NIMH, Type: R56To investigate progestin's functional effects and mechanisms through pregnane xenobiotic receptor in cycling and hormone-primed rats

"Is estrogen receptor β a target for beneficial effects of androgens in an animal model of andropause?"P.I. Cheryl A. Frye, Ph.D.; Total Costs: $59,968Dates of Proposed Project: 9/1/08-8/31/10; Annual Direct: $39,583Agency: Karo Bio Type: Drug ContractThe main goal of this project is to investigate ERβ’s actions in andropause and the trophic effects of treatment on prostate tissues.

“A drug contract to investigate behavior and trophic effects of some of their proprietary estrogens that have actions at estrogen receptor β”P.I. Cheryl A. Frye, Ph.D.; Total Costs: $69,985Dates of Proposed Project: 3/1/08-12/31/10; Annual Direct: $43,850Agency: Karo Bio Type: Drug ContractThis project is for drug development to establish more effective hormone replacement strategies.

“Northeast Under/graduate Research Organization for Neuroscience 2010-2011”PI: Cheryl A. Frye, Ph.D.; Total Costs: $10,000Dates of Project: 4/1/11-3/31/12; Annual Direct: $10,000Agency: NSF, Type: ConferenceTo support the 2010-2011 program for this conference oriented to enhanced training of neuroscientists.

5

“Northeast Under/graduate Research Organization for Neuroscience 2009-2010”PI: Cheryl A. Frye, Ph.D.; Total Costs: $9,000Dates of Project: 11/1/09-10/31/10; Annual Direct: $9,000Agency: NSF, Type: ConferenceTo support the 2009-2010 program for this student/faculty conference for enhanced training of neuroscientists.

“A conference grant to support the International Conference on Steroids & The Nervous System”P.I.: Cheryl A. Frye, Ph.D.; Total Direct: $14,000Period: 2/1/09-1/31/10; Annual Direct: $14,000Agency: NSF, Type: Conference GrantThis is to support an international conference and to enhance training of neuroendocrinologists at the venue.

“Progestins’ non-genomic actions for sex behavior”P.I.: Cheryl A. Frye, Ph.D.; Total Costs: $1,146,075Period: 6/1/04-09/14/09; Annual Direct: ~$150,000Agency: NIMH, Type: R01To delineate mechanisms, sources, and effects of progestins underlying appetitive aspects of mating behavior in rats.

“Conversation in the Capital District”P.I.: Cheryl A. Frye, Ph.D.; Total Costs: $80,000Period: 6/1/08-5/31/10Annual Direct: $80,000Agency: VariousThis is to support the Conversation in the Capital District Conference October 23-24, Albany, NY and publication of a special issue in Physiology & Behavior about this meeting.

“The role of progestins for socio-sexual behavior of mice”PI/Mentor Cheryl A. Frye, Ph.D.; Total Costs: $59,069Period: 5/31/08-9/14/09; Annual Direct: $59,069Trainee: Carolyn J. Koonce, B.A.Agency: NIMH, Type: Post-baccalaureate supplementThis purpose of this project was to investigate progestins role in socio-sexual behavior of mice.

“Mechanisms of estrogen and selective estrogen receptor modulators to reduce anxiety and depression behavior, without proliferative effects, in a menopausal model”PI/Mentor: Cheryl A. Frye, Ph.D.; Total Costs: $90,000Dates of Project: 6/1/06-5/31/10; Annual Direct: $27,000Agency: DOD, BCRP, Type: Pre-doctoral Grant; Trainee: Alicia WalfGoals were to investigate estrogen’s mechanisms to mediate affect concomitant with effects on cell proliferation in breast and uterine tissues in female rodents.

“Northeast Under/Grad Research Organization for Neuroscience”P.I. Cheryl A. Frye, Ph.D.; Total Cost: $102,309Period: 4/1/06-3/31/10; Annual Direct: $34,103Agency: NIH, Type: Conference GrantThis project is to support a student/faculty conference oriented to enhancing training of neuroscientists.

6

“Increasing U.S. Participation in 5th Pharmacology, Biochemistry, & Behavior Conference”PI: Cheryl A. Frye, Ph.D.; Total Costs: $10,000Period: 4/1/04-3/31/05; Annual Direct: $10,000Agency: NSF, Type: Conference GrantThe goal of this funding was to provide pedagogical resources and tangible support for senior investigators and trainees from the U.S.

“Non-genomic actions of progestins in the VTA for lordosis”PI: Cheryl A. Frye, Ph.D.; Total Cost: $370,000Period: 9/1/03-8/31/08; Annual Direct: $80,000Agency: NSFInvestigates progestins’ actions, via signal transduction pathways, to mediate consummatory aspects of mating, lordosis, of female rodents

“Effects and mechanisms of progestins' modulation of seizure activity”PI/Mentor: Cheryl A. Frye, Ph.D.; Total Cost: $16,000Period: 7/01/03-6/30/04; Annual Direct: $16,000Trainee: Madeline E. RhodesAgency: Epilepsy Foundation of America, Type: Ph.D. FellowshipThe major goal of this project was to investigate progestins’ mechanisms in the hippocampus to mediate ictal activity in a rodent model.

“Actions of estrogen in the nucleus accumbens for conditioning”PI: Cheryl A. Frye, Ph.D.; Total Cost: $30,000Period: 6/1/03-5/31/04; Annual Direct: $30,000Agency: Lilly Centre for Women’s Health, Type: Grant in support of women’s researchThe major goals of this project are to investigate estrogens' effects on conditioning and mechanisms in the nucleus accumbens.

“Increasing U.S. Participation- International Conference on Steroids and Brain”PI: Cheryl A. Frye, Ph.D.; Total Costs: $15,000Period: 3/1/03-2/29/04; Annual Direct: $15,000Agency: NSF, Type: Conference GrantThe goal of this funding was to provide pedagogical resources and tangible support for senior investigators and trainees from the U.S.

“A summer program in neuroscience at SUNY-Albany”PI: Gregory Lnenicka, Ph.D., co-PI: Cheryl A. Frye, Ph.D.Total Costs: $304,200Period: 4/1/01-3/31/04Annual Direct: $90,000Agency: NSF, Type: REUThe major goal of this project was to provide undergraduates neuroscience research experience with a SUNY- Albany faculty member.

“Effects of PDE Inhibitors in an animal model of female sexual dysfunction”PI: Cheryl A. Frye, Ph.D.; Total Costs: $50,000Period: 1/1/00-1/1/01; Annual Direct: $50,000Agency: Eli Lilly, Inc., Type: Contract

7

Screened potential therapeutics to determine effects on female sexual responsiveness in hamsters. This contact was an essential part of the development and/or approval of the drug Cialis.

"NEURON: North East Under/graduate Research Organization for Neuroscience”PI: Cheryl A. Frye, Ph.D.; Total Costs: $86,274Period: 9/1/99-8/31/04; Annual Direct: $17,250Agency: NIMH, Type: R13The major goals of this project were to support a student/faculty conference oriented to enhanced training of neuroscientists.

“Neurosteroids effects on sexual receptivity”PI: Cheryl A. Frye, Ph.D.; Total Cost: $539,003Period: 2/1/96-8/31/03; Annual Direct: $539,003Agency: NSF, Type: CAREER GrantInvestigated actions of progestins via GABAA receptors to mediate lordosis of female rodents.

“Neurosteroids’ role in cognitive, affective, & neurodegenerative disorders"PI: Cheryl A. Frye, Ph.D.; Total Cost: $90,000Period: 6/1/96-5/31/00; Annual Direct: $90,000Agency: Whitehall Foundation, Type: Grant-in-AidInvestigated neurosteroids role in cognitive and affective behavior and neurodegenerative disorders.

“Neurosteroids’ role in epilepsy”PI: Cheryl A. Frye, Ph.D.; Total Cost: $180,000Period: 6/1/96-8/31/00; Annual Direct: $180,000Agency: Donaghue Fdn , Type: Young Investigator AwardExamined progestins' effects on ictal activity in animal models of catamenial epilepsy.

“Progestins’ actions in the VTA for lordosis”PI: Cheryl A. Frye, Ph.D.; Total Cost: $25,000Period: 2/1/96-1/31/97; Annual Direct: $25,000Agency: NIMH, Type: B-STARTAlthough funded, declined award to pursue CAREER grant, which had overlapping research aims.

“Androgens’ actions for inhibiting sexual receptivity”PI/Mentor: Mary S. Erskine, Ph.D.; Total Cost: $83,000Period: 1/1/93-8/31/95; Annual Direct: $83,000Agency: NIMH, Type: F32, Trainee: Cheryl A. Frye, Ph.D.Examined effects and mechanisms of androgenic neurosteroids to inhibit sexual receptivity in rodents.

“Neurosteroids’ role in affect and cognition”PI: Cheryl A. Frye, Ph.D; Total Cost: $25,000Period: 5/1/93-4/30/94; Annual Direct: $25,000Agency: NSF, Type: Research Planning GrantA grant to investigate how neurosteroids alter cognition, affective and feeding and pain processes.

INTRAMURAL SUPPORTSOURCE TYPE TIME FUNDSUAlaska Start up Spring 2013 $1,200,000

8

SUNY-Albany Contraceptives Awareness Support Spring 2010 $650SUNY-Albany Brain Awareness Week Support Spring 2010 $650Research Foundation Conference Support Award- CID Spring 2009 $1500Research Foundation Conference Support Award- CID Spring 2009 $1500SUNY-Albany Faculty Research Award Program- B Spring 2009 $3000SUNY-Albany Brain Awareness Week Support Spring 2009 $750Research Foundation Conversation in the Discipline Fall 2008 $1000SUNY-Albany Conversation in the Discipline Fall 2008 $5000SUNY-UAS Conversation in the Discipline Fall 2008 $1000SUNY-Albany Conversation in the Discipline Fall 2008 $5000SUNY-Albany Symposium Support Spring 2008 $500SUNY-Albany Brain Awareness Week Support Spring 2008 $1,500SUNY-Albany Conference Support Grant Spring 2008 $1,500SUNY-Albany McNair Minority Student Support Summer 2004 $3,000SUNY-Albany Research Incentive Award Summer 2004 $5,000SUNY-Albany Conference Support Grant Spring 2004 $700

SUNY-Albany Affirmative Action Grant Summer 2003 $250SUNY-Albany Research Incentive Award Summer 2003 $5,000SUNY-Albany Affirmative Action Grant Summer 2002 $700SUNY-Albany McNair Minority Student Support Summer 2002 $1,000SUNY-Albany McNair Minority Student Support Summer 2001 $1,000SUNY-Albany STAR Undergrad Research Grant October 2001 $1,000SUNY-Albany Faculty Research Award Program February 2001 $10,000SUNY-Albany Professional development Award January 2001 $800SUNY-Albany Professional development Award May 1999 $1,000SUNY-Albany Faculty Research Award Program December 1998 $10,000SUNY-Albany Start-up Funds September 1998 $77,000

Connecticut College Pfizer Foundation 1995-1998 $200,000Connecticut College Johnson Fund 1995-1998 $4,300Connecticut College Start-up Funds September 1995 $100,000

Bates College Howard Hughes Research Program Summer 1993 $3,500Bates College Schmutz Grant for Faculty Research December 1992 $5,000Bates College Start-Up Funds for 1 year

AppointmentSeptember 1992 $5,000

Tufts University Dissertation Research Grant February 1991 $1,500

SMALL GRANTSSOURCE TYPE TIME FUNDSAmerisciences Research Trainee Support Fall 2008 $4,500Elsevier Support for Conversation in the

DisciplineSummer 2008 $61,000

Amerisciences Summer Research Fellowship for JonFreidman

Summer 2008 $2,000

NIH Microarray Consortium Spring 2008-2009

$6,000

9

NIH Microarray Consortium Spring 2008-2009

$6,000

NIH Microarray Consortium Spring 2008-2009

$6,000

NIH Microarray Consortium Summer 2007-2008

$6,000

NIH Microarray Consortium January 2008 $11,150Harvard PilgrimHealth Care

NEURON mentoring project Fall 2007-2008 $500

NIH Microarray Consortium January 2007 $3150Epilepsy F’dation Summer Fellowship April 2000 $2,000Endocrine Society Summer Fellowship April 1999 $2,500Parkinsons F’dation Summer Fellowship February 2001 $900Sigma Xi Grant-in-Aid March 1991 $750Sigma Xi Grant-in-Aid August 1990 $800Sigma Xi Grant-in-Aid March 1989 $600

TRAVEL GRANTSSOURCE TYPE TIME FUNDSSUNY-Albany Travel Grant Spring 2009 $500SUNY-Albany Travel Grant Spring 2008 $1,500NIAAA Travel Grant September 2006 $1,500SUNY-Albany Faculty Travel Award January 2006 $900SUNY-Albany Faculty Travel Award February 2003 $900ACNP Young Investigator Fellowship January 2002 $2,000Neurobio Epilepsy Young Investigator Fellowship May 2001 $1,500SUNY-Albany Faculty Travel Award February 2001 $900SUNY-Albany Faculty Travel Award May 2000 $850WCBR Post-Doc Travel Award January 1994 $1,500Workshop Steroids Post-Doc Travel Award March 1993 $1,200

10

REFEREED-PUBLICATIONS (Google H-Factor: 57, citation index: 10364)251. Frye, C.A., Koonce, C.J., Walf, A.A., and Rusconi, J.C. (2013). Motivated behaviors and levels of 3,5-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats. Journal of Sexual Medicine (in press).250. Walf A.A., Frye, C.A. (2012) Gestational or acute restraint in adulthood reduces levels of 5-reduced testosterone metabolites in the hippocampus and produces behavioral inhibition of adult male rats. Front Cell Neurosci. 2012;6:40: 1-11.249. Kohtz A.S., Frye, C.A. (2012) Dissociating behavioral, autonomic, and neuroendocrine effects of androgen steroids in animal models. Methods Mol Biol. 2012;829:397-431.248. Panzica, G.C. Balthazart, J., Frye, C.A. Garcia-Segurra, L.M., Herbison, A.E., Mensah-Nyguyen, G., McCarthy, M.M., Melcangi, R.C. (2012). Milestones on steroids and the nervous system: Ten years of basic and translational research. Journal of Neuroendocrinology. 24, 1-15.247. Frye, C.A. Bo, E., Calamandrei, G., Calza, L., Dessı-Fulgheri, Fernandez–, F., Fusani, L., Kah, O., Kajta, M., Le Page, Y., Patisaul, H.B., , Venerosi, A., Wojtowicz, A.K., Panzica, G.C. (2012) Endocrine disrupters: A review of some sources, effects, and mechanisms of actions on behavior and neuroendocrine systems. Journal of Neuroendocrinology. 24, 144-159.246. Koonce, C.J., Walf, A.A., Frye, C.A. (2012). Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice. Behavioural Brain Research, 5.244.245. Frye, C.A., Paris, J.J., Walf, A.A., Rusconi, JC. (2011). Effects and Mechanisms of 3,5-THP on emotion, motivation, and reward functions involving pregnane xenobiotic Receptor. Front Neurosci. 2011;5:136.244. Frye, C.A. (2011) Novel substrates for, and sources of, progestogens for reproduction. Journal ofNeuroendocrinology. 11: 961-73.243. Frye, C.A., Paris, J.J., Osbome, D.M, Joannalee, C.C., Kippin, T.E. (2011). Prenatal stress alters progestogens to mediate susceptibility to sex-typical, stress-sensitive disorders, such as drug abuse: a review. Frontiers in Psychiatry. 2: 1-15.242. Frye, C.A. (2011). Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice. Pharmacology, Biochemistry and Behavior. 99: 525-531.241. Paris, J.J., Brunton, P.J., Walf, A.A., Frye, C.A., (2011). Inhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. Journal of Neuroendocrinology, 1365-2826.240. Paris, J.J., Brunton, P.J., Russell, J.A., Frye, C.A. (2011). Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behavior of surviving pre-adolescent offspring. Stress, 14(6): 652-664. 239. Frye, C.A., Paris, J.J. (2011). Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats. J Endocrin Invest., 34, 188-199.238. Paris, J.J., Frye, C.A. (2011). Gestational exposure to variable stressors produces decrements in cognitive and neural development of juvenile male and female rats. Curr Top Med Chem, 11, 1706-1713.237. Walf, A.A., Paris, J.J., Rhodes, M.E., Simpkins, J.W., Frye, C.A. (2011). Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues. Brain Research, 1379: 119-36.236. Frye, C.A., Hirst, J.J., Brunton, P.J., Russell, J.A. (2011). Neurosteroids for a successful pregnancy. Stress,14: 1-5.235. Walf A.A., Paris, J.J., Llaneza, D.C., Frye, C.A. (2011). I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female rats. Brain Research1379:137-48.

11

234. Paris J.J., Walf, A.A., & Frye, C.A. (2011). II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus. Brain Research; 1379:149-63.233. McFadden, L. M., Paris, J.J., Mitzelfelt, M.S., McDonough, S., Frye, C.A., Matuszewich, L. (2011) Sex- dependent persistent effects of chronic unpredictable stress in the water maze. Physiol Behav. 102; 266-75.232. Frye, C.A. (2011). Progesterone reduces depressive behavior of young ovariectomized, aged progestin receptor knockout, and aged wild type mice in the tail suspension test. J Psychopharmacol, 25: 421-8.231. Frye, C.A., Paris J.J. (2011). Effects of neurosteroid actions at N-methyl-D-aspartate and GABAA receptors in the midbrain ventral tegmental area influence engagement in natural reward and motivation to explore among ovariectomized/adrenalectomized female rats. Psychopharmacology, 213: 93-103.230. Frye, C.A. and Walf, A.A. (2011). Progesterone, administered before kainic acid, reduces decrements in cognitive performance in the Morris Water Maze. Developmental Neurobiologyy, 71:142-52.229. Paris, J.J., Frye, C.A. (2011). Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation. Stress 14, 23-32.228. Frye, C.A., Rhodes, M.E. (2010) Fluoxetine-induced decrements in sexual responses of female rats and hamsters are reversed by 3,5-THP. Journal of Sexual Medicine, 7, 2670-2680.227. Lynn, C.D., Paris, J.J., Frye, C.A., Schell, L.M. (2011). Glossolalia is associated with differences in biomarkers of stress and arousal among Apostolic Pentecostals. Relig Brain Beh. 1-19.226. Frye, C.A., Walf, A.A., & Paris, J.J. (2010). Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5-reduced progestogens and anti-anxiety behavior of middle-aged rats. Behavioral Pharmacology 21, 530-9.225. Franco, C., Paris, J.J., Wulfert, E., & Frye, C.A. (2010) Male gamblers have significantly greater salivary cortisol before and after betting on a horse race, than do female gamblers. Physiology and Behavior 99, 225-9.224. Frye, C.A. (2010). Effects and mechanisms of progestogens and androgens in ictal activity. Epilepsia 51 suppl 3, 135-40.223. Frye, C.A., Bloom M.S., Wersinger S. (2010). The 50th anniversary of the discovery of the estrogen receptor—conversations about hormones then and now. Physiology and Behavior 99, 147-8.222. Frye, C.A., Bloom M.S. & Wersinger S. (2010). Androgens, autism and more. Physiology and Behavior100, 197-8.221. Frye, C.A., Edinger, K.L., Lephart, E.D., Walf, A.A. (2010). 3α-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats. Frontiers in Aging Neuroscience 2, 1-21.220. Frye, CA., Koonce, C, & Walf, AA. (2010). Mnemonic effects of progesterone to mice require formation of.3,5-THP. NeuroReport 21, 590-5.219. Frye, C.A. & Llaneza, D.C. (2010). Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice. Physiology and Behavior 100; 264-7.218. Frye, C.A., Petralia, S.M., Rhodes, M.E., DeBold, J.F. (2010). 6-hydroxydopamine lesions enhance progesterone –facilitated lordosis of rats and hamsters, independent of effects on motor behavior. Physiology and Behavior 99, 218-24.217. Frye, C.A. & Sora, I. (2010). Progesterone reduces hyperactivity of female and male dopamine transporter knockout mice. Behavioural Brain Research 209, 59-65.216. Frye, C.A. & Walf, A.A. (2010). Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral

12

tegmental area reduce effects of progesterone- and a dopamine type 1-like receptor agonist to facilitate lordosis. Behavioural Brain Research 206, 286-92.215. Frye, C.A. & Walf, A.A. (2010) Oxytocin and/or steroid hormone binding globulin infused into the ventral tegmental area modulates progestogen-mediated lordosis. Neuropharmacology 58, 44-9.214. Frye, C.A. & Walf, A.A. (2010). Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice. Neuroscience Letters 472, 38-42.213. Jensen E.V., Jacobson H.I., Walf A.A., Frye C.A. (2010). Estrogen action: A historic perspective on the implications of considering alternative approaches. Physiology and Behavior 99, 151-62.212. Kohtz, A.S., Paris, J.J., Frye, C.A. (2010). Low doses of cocaine decrease, and high doses increase, anxiety- like behavior and brain progestogen levels among intact rats. Hormones and Behavior 57, 474-80.211. Llaneza, D.C., DeLuke, S.V., Batista, M., Crawley, J.N., Christodulu, K.V. & Frye, C.A. (2010). Communication, interventions, and scientific advances in autism: A commentary. Physiology and Behavior 100, 268-76.210. Lynn, C.D., Paris J., Frye C.A,. Schell L.M.. (2010) Salivary alpha–amylase and cortisol among pentecostals on a worship day and nonworship day. American Journal of Human Biology 22, 819-22209. Paris J.J., Franco, C., Sodano, R., Frye, C.A., & Wulfert, E. (2010). Gambling pathology is associated with dampened cortisol response among men and women. Physiology and Behavior 99, 230-3.208. Paris, J.J., Franco, C., Sodano, R., Freidenberg, B., Gordis, E., Anderson, D.A., Forsyth, J.P., Wulfert, E., & Frye, C.A. (2009). Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with postraumatic stress disorder. Hormones and Behavior 57, 35-45207. Walf, A.A. & Frye, C.A. (2010). Raloxifene and/or estradiol reduce depressive-like behavior and increase anti-anxiety-like behavior, whereas only estradiol promotes uterine proliferation and carcinogen-induced tumorigenesis among ovariectomized rats. Behavioral Pharmacology 21, 231-40.206. Walf, A.A. & Frye, C.A. (2010). Estradiol reduces anxiety- and depression-like behavior of aged female mice. Physiology and Behavior 99, 169-74.205. Frye, C.A. & Koonce, C.J. (2009). Post-training administration of estrogen and/or androgens with actions at ERα and/or ERβ to male rats can improve performance in the object recognition task. Open Neuropsychopharmacology Journal 2, 16-21.204. Frye C.A. (2009). Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions. Psychoneuroendocrinology 34 Suppl 1, S143-61.203. Frye, C.A. (2009). Steroids, reproductive endocrine function, and affect: A review. Minerva Ginecological61, 541-562.202. Frye, C.A. (2009). Steroids, reproductive endocrine function, and cognition: A review. MinervaGinecological 61, 563-585.201. Frye, C.A., Llaneza, D.C. & Walf, A.A. (2009) Progesterone can enhance consolidation and/or performance in spatial, object, social, and implicit memory tasks. Animal Behaviour 78, 279-286.200. Frye, C.A. & Paris, J.J. (2009). Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats. Pharmacology, Biochemistry, and Behavior 93, 474-81.199. Frye, C.A., Paris, J.J., & Rhodes, M.E. (2009). Increasing 3α,5α-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats. Reproduction 137, 119-28.198. Frye, C.A. (2009):c 1, 1215-1231. Progestogens influence cognitive process in aging. Future Medicinal

13

Chemistry, October 2009, Vol. 1, No. 7, Pages 1215-1231.197. Frye, C.A. & Walf, A.A. (2009) Progesterone reduces depression-like behavior in a murine model ofAlzheimer’s Disease. Age 31, 143-53.196. Frye, C.A. & Walf A.A. (2009).Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites. Physiology and Behavior 97, 266-269.195. Frye, C.A., Ryan, A., & Rhodes, M. (2009). Anti-seizure effects of 17β-estradiol and 3α-androstanediol mayInolve actions at estrogen receptor β. Epilepsy and Behavior 16, 418-22.194. Gracia, C.R., Freeman, E.W., Sammel, M.D., Lin, H., Sheng, L., & Frye, C.A. (2009). Allopregnanolone levels before and after SSRI treatment for Premenstrual Symptoms. Journal of Clinical Psychopharmacology 29,403-5.193. Koonce, C.J., Walf, A.A., & Frye, C.A. (2009). Trilostane exerts anti-depressive effects among wildtype, butnot estrogen receptor β knockout mice. Neuroreport 20, 1047-50.192. Llaneza D.C. & Frye C.A. (2009). Progestogens and estrogen influence impulsive burying and avoidant freezing behavior of naturally cycling and ovariectomized rats. Pharmacol Biochem Behav 93, 337-42.191. Osborne, D.M., Edinger, K., & Frye, C.A. (2009). Chronic administration of androgens with actions atestrogen receptor β have anti-anxiety and cognitive-enhancing effects in male rats. Age 31, 191-8.190. Osborne, D.M. & Frye C.A. (2009) Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout mice. Epilepsy and Behavior16, 411-4.189. Walf A.A. & Frye C.A. (2009). Estradiol enhances sociosexual behavior and can have proliferative effects in ovariectomized rats. Age (Dordr) 31, 221-9.188. Walf, A.A. & Frye, C.A. (2009). Effects of two estradiol regimens on anxiety and depressive behaviors and trophic effects in peripheral tissues in a rodent model. Gender Medicine 6, 300-11.187. Walf, A.A., Paris, J.J., & Frye, C.A. (2009). Chronic estradiol replacement to aged female rats reduces anxiety-like and depression-like behavior and enhances cognitive performance. Psychoneuroendocrinology 34,909-16.186. Walf, A.A., Paris, J.J., & Frye, C.A. (2009). Nociceptive and anxiety-like behavior in reproductively competent and reproductively senescent middle-aged rats. Gender Medicine 6, 235-246.185. Walf A.A., Koonce C.J., Frye C.A. (2009). Adult female wildtype, but not oestrogen receptor beta knockout, mice have decreased depression-like behaviour during pro-oestrus and following administration of oestradiol or diarylpropionitrile. J Psychopharmacol 23, 442-50.184. Frye, C.A., Koonce, C.J., Edinger, K.L., Osborne D.M., & Walf, A.A. (2008). Androgens with activity at estrogen receptor β have anxiolytic and cognitive-enhancing effects in male rats and mice. Hormones and Behavior 54, 726-734.183. Walf, A.A. & Frye, C.A. (2008). Rapid and estrogen receptor β mediated actions in the hippocampus mediate some functional effects of estrogen. Steroids 73, 997-1007.182. Frye, C.A. & Walf, A.A. (2008). Membrane actions of progestins at dopamine type 1-like and GABAAreceptors involve downstream signal transduction pathways. Steroids, 73, 906-13.181. Frye, C.A., Marrone, J., & Walf, A.A. (2008). Effects of manipulating progesterone and NMDA receptors in the ventral tegmental area and lordosis of hamsters and rats. Psychopharmacology 200, 71-80.180. Frye, C.A., Paris, J.J., & Rhodes, M.E. (2008). Estrogen is necessary for 5α-pregnan-3α-ol-20-one

14

(3α,5α- THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats. Pharmacology, Biochemistry and Behavior 91, 261-270.179. Frye C.A., Paris, J.J., & Rhodes, M.E. (2008). Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3α,5α-THP formation in the midbrain ventral tegmental area. Behavioural Brain Research 193, 269-276.178. Frye, C.A. & Rhodes, M.E. (2008). Infusions of 3α,5α-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3α,5α-THP in midbrain, hippocampus, diencephalon, and cortex of female rats. Behavioural Brain Research, 187, 88-99.177. Frye, C.A., Sumida, K., & Edinger, K.L. (2008). Androgen administration to aged male mice increases anti- anxiety behavior and enhances cognitive performance. Neuropsychopharmacology 33, 1049-1061.176. Frye, C.A. & Walf A.A. (2008). In the ventral tegmental area, progestogens membrane-mediated actions for lordosis of rats involve the second messenger phospholipase C. Brain Research 1230, 218-223.175. Frye, C.A. & Walf, A.A. (2008). Activity of protein kinase C is important for 3α,5α-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats. Brain Research Bulletin 77 91-97.174. Frye, C.A. & Walf, A.A. (2008). Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze. Neurobiology of Learning and Memory 90, 171-177.173. Frye, C.A. & Walf, A.A. (2008). Progesterone enhances performance of aged mice in cortical or hippocampal tasks. Neuroscience Letters 437, 116-120.172. Frye, C.A. & Walf, A.A. (2008). Effects of progesterone administration and APPswe+PSEN1e9 mutation for cognitive performance of mid-aged mice. Neurobiology of Learning and Memory 89, 17-26.171. Paris J.J. & Frye, C.A. (2008). Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks. Reproduction 136, 105-115.170. Ryan, A. & Frye, C.A. (2008). Antiseizure effects of 5α-androstane-3α,7β-diol may be independent ofactions at estrogen receptor β. Epilepsy and Behavior 13, 32-35.169. Walf, A.A, Ciriza, I., Garcia-Segura, L.M.., & Frye, C.A. (2008). Antisense oligodeoxynucleotides for estrogen receptor and attenuate estradiol's modulation of affective and sexual behavior, respectively. Neuropsychopharmacology 33, 431-440.168. Walf, A.A. & Frye, C.A. (2008). Conjugated equine estrogen enhances rats’ cognitive, anxiety, and socialbehavior. Neuroreport 19, 789-792.167. Walf, A.A. & Frye, C.A. (2008). Parity and estrogen-administration alters anxiety and depression behavior of ovariectomized rats. Physiology and Behavior 93, 351-356.166. Walf, A.A., Koonce, C., & Frye, C.A. (2008). Adult female wildtype, but not estrogen receptor knockout, mice have decreased depression-like behavior during proestrus and following administration of estradiol or diarylpropionitrile. Journal of Psychopharmacology 23, 442-50.165. Walf, A.A., Koonce, C., & Frye, C.A. (2008). Estradiol or diarylpropionitrile administration to wildtype,but not estrogen receptor β knockout, mice enhance performance in the object recognition and object placement tasks. Neurobiology of Learning and Memory 89, 513-521.164. Walf, A.A., Koonce, C.J., & Frye, C.A. (2008). Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor β knockout, mice. Behavioral Neuroscience 122, 974-81.163. Walf, A.A., Koonce, C.J., Manley, K., & Frye, C.A. (2008). Proestrous compared to diestrous wildtype, but not estrogen receptor β knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze. Behavioural Brain Research 96, 254-60.162. Walf, A.A., Frye, C.A. (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature Protocols 2:322-328.

15

161. Edinger, K.L & Frye, C.A. (2007). Sexual experience of male rats influences anxiety-like behavior and androgen levels. Physiology and Behavior 92, 443-53.160. Edinger, K.L. & Frye, C.A. (2007). Androgens' effects to enhance learning and memory may be mediated in part through actions at estrogen receptor- in the hippocampus. Neurobiology of Learning and Memory 87, 201-8.159. Frye, C.A. (2006). Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse. Pharmacology, Biochemistry, and Behavior 86, 209-219.158. Frye, C.A. (2006). Some rewarding effects of androgens may be mediated by actions of its 5-reduced metabolite 3–Androstanediol. Pharmacology, Biochemistry, and Behavior 86, 354-367.157. Frye, C.A., Babson, A., & Walf, A.A., (2007). Self-Administration of 3-Androstanediol increases locomotion and analgesia and decreases aggressive behavior of male hamsters. Pharm Biochem Behav 86, 415-21.156. Frye, C.A., Paris, J.J. & Rhodes, M.E. (2007). Engaging in paced mating, but neither exploratory, anti- anxiety, nor social behavior, increases 5-reduced progestin concentrations in midbrain, hippocampus, striatum and cortex. Reproduction 1133, 663-674.155. Frye, C.A, & Rhodes, M.E. (2007). Infusions of 5-pregnan-3-ol-20-one (3,5-THP) to the ventral tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours and concomitantly increase 3,5-THP concentrations in the hippocampus, diencephalon and cortex of ovariectomised oestrogen-primed rats. Journal of Neuroeondocrinology 18, 960-75.154. Frye, C.A. & Walf, A.A. (2007). In the ventral tegmental area, the membrane-mediated actions of progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. Journal of Neuroendocrinology 19, 717-724.153. Kellogg, C.K., Kenjarsk,i T.P., Pleger, G.L., & Frye, C.A. (2006). Region-, age-, and sex-specific effects of fetal diazepam exposure on the postnatal development of neurosteroids. Brain Research 1067, 115-25.152. Petralia, S.M., Debold, J.F., & Frye, C.A. (2007). MK-801 Infusions to the VTA and VMH produce opposite effects on lordosis of hormone-primed rats. Pharmacology, Biochemistry, and Behavior 86, 377-385.151. Walf, A.A., Duffy, C.K., & Frye, C.A. (2007).Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiology of Learning and Memory 88, 208-216150. Walf, A.A. & Frye, C.A. (2007). Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects. Stress 10, 251-260.149. Walf, A.A. & Frye, C.A. (2007). Administration of estrogen receptor selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats. Pharmacology, Biochemistry, and Behavior 86, 407-414.148. Frye, C.A., Rhodes, M.E., Petralia, S.M., Walf, A.A., Sumida, K., & Edinger, K.L. (2006). 3α,5α-THP in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience 138, 1007-14147. Frye, C.A. (2006). An overview of oral contraceptives: Mechanism of action and clinical use. Neurology 66,S29-6146. Frye, C.A. (2006). The role of androgens in epilepsy. Expert Review of Neurotherapeutics 6, 7:1061-1076.145. Walf, A.A., Frye, C.A. (2006). A review and update: Estrogen’s effects, brain targets, and mechanisms for anxiety and depression behavior Neuropsychopharmacology, 31(6):1097-11.144. Ciriza, I., Carrero, P., Walf, A.A., Frye, C.A., & Garcia-Segura, L.M. (2006). Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin

16

mderoxyprogesterone acetate is not neuroprotective. Journal of Neurobiology 66, 916-28.143. Edinger, K.L & Frye, C.A. (2007). Androgens’ performance-enhancing effects in the inhibitory avoidance and water maze tasks may involve actions at intracellular androgen receptors in the dorsal hippocampus. Neurobiology of Learning and Memory 87, 201-208.142. Edinger, K.L. & Frye C.A. (2006). Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats. Hormones and Behavior 50, 216-220.141. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area.. Hormones and Behavior 50, 237-44.140. Frye, C.A, & Rhodes, M.E. (2006) Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats. Neuroendocrinology 83, 336-47.139. Frye, C.A, & Rhodes, M.E. (2006). Administration of estrogen to ovariectomized rats promotes conditioned place preference and produces moderate levels of estrogen in the nucleus accumbens. Brain Res 1067, 209-215.138. Frye CA, Rhodes ME, Raol Y, & Brooks-Kayal AR. (2006). Early postnatal stimulation alters pregnane neurosteroids in the hippocampus. Psychopharmacology 186, 343-50.137. Frye. C.A., Sumida, K., Dudek, B.C., Harney, J.P., Lydon, J.P., O'Malley, B.W., Pfaff, D.W., & Rhodes, M.E. (2006). Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors. Psychopharmacology 186, 312-22.136. Frye, C.A., Sumida, K., Lydon, J.P., O’Malley, B.W., & Pfaff, D. (2006). Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3,5-THP-facilitated lordosis. Psychopharmacology 186, 423-32.135. Frye CA, Sumida K, Zimmerberg B, & Brunelli SA. (2006). Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP levels as adults. Behavioral Neuroscience 120, 281-9.134. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). Progestins’ effects on sexual behavior of female rats and hamsters involving D1 and GABAA receptors in the ventral tegmental area may be G-protein-dependent. Behavioral Brain Research 172, 286-293.133. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABAA receptors. Hormones and Behavior 50, 332-7.132. Frye, C.A., Walf, A.A, & Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area. Hormones and Behavior 50, 332-337.131. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L., & Frye, C.A. (2006). Differential effects of antiepileptic drugs on neuroactive steroids in men with epilepsy. Epilepsia 47, 1945-8.130. Petralia, S.M. & Frye, C.A. (2006). In the ventral tegmental area, G-proteins mediate progesterone’s actions at dopamine type 1 receptors for lordosis of rats and hamsters Psychopharmacology 186, 133-42.129. Petralia SM, & Frye CA. (2006). In the ventral tegmental area, cAMP mediates progesterone’s actions atdopamine type 1 receptors for lordosis of rats and hamsters. Journal of Neuroendocrinology 18, 902-14.128. Petralia, S.M., Walf, A.A., & Frye, C.A. (2006). In the ventral tegmental area, progestins’ membrane- mediated actions for lordosis of hamsters and rats involve protein kinase A. Neuroendocrinology 84, 405-414.127. Rhodes, M.E. & Frye, C.A. (2006). ER-selective SERM produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks. Neurobiology of Learning Memory 85, 183-91.

17

126. Smith, C.D., Wekstein, D.R., Markesbury, W.R., & Frye, C.A. (2006). 3, 5-THP: a potential plasma neurosteroid biomarker in Alzheimers Disease. Psychopharmacology 186, 481-485.125. Walf, A.A., Rhodes, M.E., Meade, J., Harney, J.P., & Frye, C.A. (2006). Estradiol-induced conditioned place preference may require actions at estrogen receptors in the nucleus accumbens. Neuropsychopharmacology 32, 522-530.124. Walf, A.A., Rhodes, M.E., & Frye, C.A. (2006). Ovarian steroids enhance object recognition in naturally- cycling and ovariectomized, hormone-primed rats. Neurobiology of Learning and Memory 86, 35-46.123 Walf, A.A., Sumida, K., & Frye, C.A. (2006). Inhibiting 5-reductase in the amygdala attenuates anti- anxiety and anti-depressive behavior of naturally-receptive and hormone-primed ovariectomized rats. Psychopharmacology 186, 302-311.122. Frye, C.A. & Rhodes, M.E. (2005) Estrogen-priming can enhance progesterone’s anti-seizure effects in part by increasing hippocampal levels of allopregnanalone. Pharmacology, Biochemistry, and Behavior 81, 907-16.121. Rhodes, M.E., Talluri, J., Harney, J.P., & Frye, C.A. (2005). Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. Epilepsy and Behavior 7, 231-9.120. Frye, C.A., & Rhodes, M.E. (2005). Progesterone’s 5-reduced metabolite, 3, 5-THP, mediates lateral displacement of hamsters. Brain Research 1038, 59-68.119. Frye, C.A., Rhodes, M.E., & Dudek, B.C. (2005). Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks. Brain Research 1036, 101-8.118. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L.,& Frye, C.A. (2005). Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. Neurology 65, 1016-20.117. Petralia, S.M. & Frye, C.A. (2005). In the ventral tegmental area, picrotoxin blocks FGIN-1-27-induced increases in sexual behavior of rats and hamsters. Psychopharmacology,178, 174-82.116. Petralia SM, Jahagirdar V, & Frye CA. (2005). Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus. Journal of Neuroendocrinoogy 17, 545-52.115. Rhodes, M.E. & Frye, C.A. (2005). Attenuating 5-pregnane-3-0l-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures. Epilepsy and Behavior 6; 140-6.114. Rhodes M.E. & Frye C.A. (2005). Actions at GABAA receptors in the hippocampus may mediate some ofprogestins’ anti-seizure effects. Epilepsy and Behavior 6, 320-7.113. Smith, S.S., Ruderman, Y., Frye, C., Homanics, G., & Yuan, M.(2005). Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5α-THP: a possible model of premenstrual dysphoric disorder. Psychopharmacology 29, 1-11.112. Sumida, K., Walf, A.A., & Frye, C.A. (2005). Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area. Behavioural Brain Research 3, 161, 1-7.111. Walf, A.A. & Frye, C.A. (2005). Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity. Neuropsychopharmacology,30, 1288-301.110. Walf, A.A. & Frye, C.A. (2005). ER -selective estrogen receptor modulators produce anti-anxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology 30, 1598-609.109. Zimmerberg, B., Brunelli, S. A., Fluty, A. J., & Frye, C. A. (2005). Differences in affective behaviors and hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations.

18

Behavioral Brain Research, 159: 301-11.108. Rhodes, M.E. & Frye, C.A. (2004). Androgens in the hippocampus can alter, and be altered by, ictal activity.Pharmacology, Biochemistry, and Behavior 78, 483-493.107. Edinger, K.L. & Frye, C.A. (2004). Testosterone’s analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5-reduced metabolites in the hippocampus. Behavioral Neuroscience 118, 1352-64.106. Edinger, K.L., Lee, B., & Frye, C.A. (2004). Mnemonic effects of testosterone and its 5-reduced metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacology, Biochemistry, & Behavior 78, 559-568.105. Frye, C.A & Edinger, K.L. (2004). Testosterone’s metabolism in the hippocampus mediates its anti-anxiety effects in male rats. Pharmacology, Biochemistry, & Behavior 78, 473-481.104. Frye, C.A., Edinger, K.L.,Seliga, A.M., & Wawrzycki, J.M. (2004). 5-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 29, 1019-1027.103. Frye, C.A. & Walf, A.A. (2004). Hippocampal 3,5-THP may alter depressive behavior of pregnant and lactating rats. Pharmacology, Biochemistry, & Behavior 78, 531-540102. Frye, C.A. & Walf, A.A. (2004). Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats. Behavioral Neuroscience 118, 306-13.101. Frye, C.A., Walf, A.A., & Sumida, K. (2004). Progestins’ actions in the VTA to facilitate lordosis involvedopamine-like Type 1 and 2 Receptors. Pharmacology, Biochemistry, and Behavior 78, 405-418.100. Frye, C.A., Walf, A.A., Rhodes, M.E., & Harney, J.P. (2004). Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5-reductase. Brain Research 1004, 116-124.99. Petralia, S.M. & Frye, C.A. (2004). In the ventral tegmental area, G-proteins and cAMP mediate 3α,5α-THP’sactions at dopamine type 1 receptors for lordosis of rats. Neuroendocrinology 80, 233-43.98. Rhodes, M.E. & Frye, C.A. (2004). Progestins in the hippocampus of female rats have anti-seizure effects in a pentylenetetrazole seizure model. Epilepsia 45, 1531-8.97. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Kelly, K.M., Farina, E.L., & Frye, C.A. (2004). Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia 45, 764-8.96. Rhodes, M.E. & Frye, C.A. (2004). Estrogen has mnemonic enhancing effects in the inhibitory avoidance task. Pharmacology, Biochemistry, & Behavior 78, 551-558.95. Rhodes, M.E., Harney, J.P., & Frye, C.A. (2004). Gonadal, adrenal, and neuroactive steroids’ role in ictalactivity. Brain Research 1000, 8-18.94. Rhodes, M.E., McCormick, C.M., & Frye, C.A. (2004). 3,5-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacology, Biochemistry, & Behavior 78, 505-512.93. Walf, A.A., Rhodes, M.E., & Frye, C.A. and (2004). Anti-depressant effects of ER selective estrogen receptor modulators in the forced swim test. Pharmacology, Biochemistry, & Behavior 78, 483-493.92. Frye, C.A. & Wawrzycki, J. (2003). Effect of prenatal stress and gonadal hormone condition on depressive behavior of female and male rats. Hormones and Behavior 44, 319-326.91. Frye, C.A. & Seliga, A.M. (2003).Effects of olanzapine infusions to the VTA on lordosis and midbrain

19

3,5-THP concentrations in rats. Psychopharmacology 170, 132-139.90. Frye, C.A., Petralia, S.M., Rhodes, M.E., & Stein, B. (2003). Fluoxetine may influence lordosis of ratsthrough effects on midbrain 3,5-THP concentrations. Annals of the New York Academy of Science 1007, 37-41.89. Walf, A.A. & Frye, C.A. (2003). Anti-nociception following exposure to trimethylthiazoline, peripheral or intra-amygdala estrogen and/or progesterone. Behavioural Brain Research 144, 77-85.88. Frye, C.A. & Seliga, A.M. (2003). Olanzapine's effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats. Psychoneuroendocrinology28, 657-673.87. Frye, C.A. & Petralia, S.M. (2003). Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters. Jounral of Neuroendocrinology 15, 677-686.86. Frye, C.A. & Petralia, S.M. (2003). Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmenal area. Neuroendocrinology 77,71-82.85. Herzog, A.G. & Frye, C.A. (2003). Seizure exacerbation associated with inhibition of progesterone metabolism. Annals of Neurology 53, 390-391.84. Frye, C.A. & Rhodes, M.E. (2003). Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters. Neuropsychopharmacology 28, 310-316.83. Frye, C.A. & Rhodes, M.E. (2002). Enhancing effects of estrogen on inhibitory avoidance performance may be in part independent of intracellular estrogen receptors in the hippocampus. Brain Research 956, 285-293.82. Frye, C.A., Rhodes, M.E., Walf, A., & Harney, J.P. (2002). Testosterone enhances aggression in wild type mice but not mice deficient in Type I 5-reductase. Brain Research 948, 165-170.81. Frye, C.A. & Orecki, Z.A. (2002). Prenatal stress alters reproductive responses of rats in behavioral estrus and paced mating of hormone-primed rats. Hormones and Behavior 42, 472-483.80. Frye, C.A., Rhodes, M.E., Rosellini, R. & Svare, B. (2002). The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5-reduced metabolites. Pharmacology, Biochemistry, & Behavior 74, 119-127.79. Freeman, E.W., Frye, C.A., Rickels, K., Martin, P.A.G. & Smith S.S. (2002). Allopregnanolone levels and symptom improvement in severe premenstrual syndrome. Journal of Clinical Psychopharmacology 22, 516-20.78. Seliga, A. & Frye, C.A. (2002). Olanzapine and progesterone dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats. Physiology and Behavior 76, 151-158.77. Schmitz, C., Rhodes, M.E., Bludau, M., Kaplan, S., Ong, S., Ueffing, I., Vehoff, J., Korr, H. & Frye, C.A. (2002). Depression: reduced number of granule cells in the hippocampus of female, but not male, rats due to prenatal restraint stress. Molecular Psychiatry 7, 810-813.76. McCormick, C.M., Kehoe, P., Mallinson, K., Cecchi, L., & Frye, C.A. (2002). Neonatal isolation alters stress hormone and mesolimbic dopamine release in juvenile rats. Pharmacol Biochem Behav 73, 77-85.75. Frye, C.A. & Orecki, Z. (2002). Prenatal stress producing deficits in socio-sexual behavior of cycling, but not hormone-primed, Long-Evans rats. Pharmacology, Biochemistry, and Behavior 73, 53-60.74. Frye, C.A., Rhodes, M.E., Walf, A.A., and Harney, J. (2002). Progesterone reduces pentylenetetrazol- induced ictal activity of wild type mice but not those deficient in Type I 5-reductase. Epilepsia 43, 14-17.73. Frye, C.A. & Walf, A.A. (2002). Changes in progesterone metabolites in the hippocampus can

20

modulate open field and forced swim test behavior of proestrous rats. Hormones and Behavior 41(3), 306-315.72. Anderson, D. A., Shapiro, J. R., Lundgren, J. D., Spataro, L. E., & Frye, C. A. (2002). Self-reported dietary restraint is associated with elevated levels of salivary cortisol. Appetite 38, 13-17.71. Frisone, D.F., Frye, C.A. & Zimmerberg B. (2002). Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats. Behavioral Brain Research 128, 153-160.70. Rosellini, R.A., Rhodes, M.E., Svare, B.B. & Frye, C.A. (2001). The testosterone metabolite and neurosteroid 3-Androstanediol may mediate the effects of testosterone on conditioned place preference. Brain Research Reviews, 37, 162-171.69. Frye, C.A. (2001). The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents. Brain Research Reviews, 37, 201-222.68. Frye, C.A. (2001). The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents. Hormones and Behavior, 40, 226-233.67. Frye, C.A. & Seliga, A.M. (2001). Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats. Cognitive and Affective Behavioral Neuroscience 1, 371-381.66. Frye, C.A. & Vongher, J.M. (2001). Ventral tegmental area infusions of inhibitors of the biosynthesis and metabolism of 3,5-THP attenuate lordosis of hormone-primed and behavioral oestrous rats and hamsters. Jounral of Neuroendocrinology 13, 1076-1086.65. Frye, C.A., Rhodes, M.E., Walf, A.A., & Harney, J.P. (2001). Testosterone reduces pentylenetetrazole- induced ictal activity in wild type mice but not those deficient in Type I 5-reductase. Brain Res 918, 182-186.64. Rhodes, M.E. & Frye, C.A. (2001). Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrous decreases anxiolytic, and enhances exploratory and anti-nociceptive behaviors. Cognitive and Affective Behavioral Neuroscience 1, 287-296.63. Frye, C.A. & Vongher, J.M. (2001). Progesterone and 3,5-THP enhance sexual receptivity in mice.Behavioral Neuroscience 115, 1118-1128.62. Altemus,M., Redwine, L.S., Leong, Y.M., Frye, C.A., Porges, S.W., & Carter, C.S. (2001). Responses to laboratory psychosocial stress in post-partum women. Psychosomatic Medicine 63, 814-821.61. Frye, C.A. & Muscatiello, N.A. (2001). 3,5-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures. Brain Research 911, 146-151.60. Frye, C.A., Park, D., Tanaka, M., Rosellini, R., & Svare, B. (2001). The testosterone metabolite and neurosteroid 3-androstanediol may mediate the effects of testosterone on conditioned place preference. Psychoneuroendocrinology 26, 731-750.59. Frye, C.A. & Lacey, E.H. (2001). Posttraining androgens’ enhancement of cognitive performance is temporally distinct from androgen’ increases in affective behavior. Cognitive and Affective Behavioral Neuroscience 1, 172-182.58. Frye, C.A. (2001). Inhibition of 5-reductase enzyme or GABA(A) receptors in the VMH and the VTAattenuates progesterone-induced sexual behavior in rats and hamsters. Journal of Endocrinological Investigation,24, 399-407.57. Frye, C.A. (2001). Estradiol tends to improve inhibitory avoidance performance in adrenalectomized male rats and reduces pyknotic cells in the dentate gyrus of adrenalectomized male and female rats. Brain Research 889, 358-363.56. Kehoe, P., Mallinson, K., McCormick, C.M. & Frye, C.A. (2000). Central allopregnanolone is increased in rat pups in response to repeated, short episodes of neonatal isolation. Developmental Brain Research 124, 133-136.55. Frye, C.A. & Lacey, E.H. (2000). Progestins influence performance on cognitive tasks independent of

21

changes in affective behavior. Psychobiology 28, 550-563.54. Frye, C.A., Manjarrez, J., & Camacho-Arroyo, I. (2000). Infusion of 3,5-THP to the pontine reticular formation attenuates PTZ-induced seizures. Brain Research 881, 98-102.53. Frye, C.A., Petralia, S.M., & Rhodes, M.E. (2000). Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 35-THP. Pharmacology, Biochemistry, and Behavior 67, 587-596.52. Frye, C.A., Murphy, R.E., & Platek, S.M. (2000). Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats. Behavioral Brain Research 115, 55-64.51. Bitran, D., Foley, M., Audette, D., Leslie, N. & Frye, C.A. (2000). Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat. Psychopharmacology 151, 64-71.50. Frye, C.A. & McCormick, C.M. (2000). Androgens are neuroprotective in the dentate gyrus of adrenalectomized female rats. Stress 3, 185-194.49. Frye, C.A., Bayon, L.E. & Vongher, J.M. (2000). Intravenous progesterone elicits a more rapid induction of lordosis in rats than does SKF38393. Psychobiology 28, 99-109.48. Frye, C.A. & Scalise, T.J. (2000). Anti-seizure effects of progesterone and 3,5 -THP in kainic acid and perforant pathway models of epilepsy. Psychoneuroendocrinology 25, 407-420.47. Frye, C.A. & McCormick, C.M. (2000). The neurosteroid, 3-Androstanediol, prevents inhibitory avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats. Brain Research 855, 166-170.46. Kelsey, J.E., Sanderson, K.L., & Frye, C.A. (2000). Perforant path stimulation in rats produces seizures, loss of hippocampal neurons, and a deficit in spatial mapping which is reduced by prior MK-801. Behavioral Brain Research 107, 59-69.45. Vongher, J.M. & Frye, C.A. (1999). Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration. Pharmacology, Biochemistry and Behavior 64, 777-785.44. Frye, C.A. & Bayon, L.E. (1999). Mating stimuli influence endogenous variations in the neurosteroids3,5-THP and 3-Diol. Journal of Neuroendocrinology 11, 839-847.43. Frye, C.A. & Vongher, J.M. (1999). Progestins’ rapid facilitation of lordosis when applied to the ventraltegmentum corresponds to efficacy at enhancing GABAA receptor activity. Journal of Neuroendocrinology 11,829-837.42. Frye, C.A. & Vongher, J.M. (1999). GABAA, D1, and D5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis. Behavioral Brain Research, 103, 23-34.41. Frye, C.A. & Vongher, J.M. (1999). 3,5-THP in the midbrain ventral tegmental area of rats and hamsters is increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity. Journal of Endocrinological Investigation 22, 455-464.40. Kellogg, C.K. & Frye, C.A. (1999). Endogenous levels of 5-reduced progestins and androgens in fetal vs. adult rat brains. Developmental Brain Research 115, 17-24.39. Frye, C.A. & Lacey, E.H. (1999). The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state. Physiology & Behavior 66, 85-92.38. Wilson, M.A. & Frye, C.A. (1999). Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels. Brain Research 824, 136-139.37. Frye, C.A. & Bayon, L.E. (1999). Prenatal stress reduces the effectiveness of the neurosteroid 3,5-THP toblock kainic-acid-induced seizures. Developmental Psychobiology 34, 227-234.

22

36. Morgan, K.N., Thayer, J.E. & Frye, C.A. (1999). Prenatal stress suppresses rat pup ultrasonic vocalization and myocolonic twitching in response to separation. Developmental Psychobiology 34, 205-215.35. Frye, C.A. & Vongher, J.M. (1999). Progesterone has rapid and membrane effects in the facilitation of female mouse sexual behavior. Brain Research 815, 259-269.34. Frye, C.A. & Bayon, L.E. (1999). Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures. Pharmacology, Biochemistry and Behavior 62, 315-321.33. Frye, C.A., Bayon, L.E., Pursnani, N. & Purdy, R.H. (1998). The neurosteroids, progesterone and 3,5- THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Research 808, 72-83.32. Dunn, R.W., Reed, T.A.W., Copeland, P.D. & Frye, C.A. (1998). The nitric oxide synthase inhibitor 7- nitroindazole displays enhanced anxiolytic efficacy without tolerance in rats following subchronic administration. Neuropharmacology 37, 899-904.31. Frye, C.A. & Bayon, L.E. (1998). Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3,5-THP. Neuroendocrinology 68, 272-280.30. Smith, S.S., Gong, Q.H., Li, X., Moran, M.H., Bitran, D., Frye, C.A. & Hsu, F.C. (1998). Withdrawal from3-OH-5-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor 4 subunit in association with increased anxiety. Journal of Neuroscience 18, 5275-5284.29. Frye, C.A. & Reed, T.A. (1998). Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy. Psychoneuroendocrinology 23, 385-399.28. Frye, C.A., Scalise, T.J. & Bayon, L.E. (1998). Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. Journal of Neuroendocrinology 10, 291-296.27. Bitran, D., Hilvers, R.J., Frye, C.A. & Erskine, M.S. (1996). Chronic anabolic-androgenic steroid treatment affects brain GABAA receptor-gated chloride ion transport. Life Sciences 58, 573-583.26. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Progesterone and 3-Androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA. Behavioral Neuroscience 110, 603-612.25. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Analgesic effects of the neurosteroid 3- Androstanediol. Brain Research 709, 1-9.24. Frye, C.A., McCormick, C.M., Coopersmith, C. & Erskine, M.S. (1996). Effects of paced and non-paced mating stimulation on plasma progesterone, 3-Diol and corticosterone. Psychoneuroendocrinology 21, 431-439.23. Frye, C.A., Duncan, J.E., Basham, M. & Erskine, M.E. (1996). Behavioral effects of 3-Androstanediol II: Hypothalamic and preoptic area actions via GABAergic mechanism. Behavioral Brain Research 79, 119-130.22. Frye, C.A., Van Keuran, K.R. & Erskine, M.S. (1996). Behavioral effects of 3-Androstanediol I:modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behavioral Brain Research79, 109-118.21. Frye, C.A. & Gardiner, S.G. (1996). Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity. Hormones and Behavior 30, 682-691.20. Frye, C.A. & Duncan, J.D. (1996). Estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity. Pharmacology, Biochemistry and Behavior 53, 27-32.19. Frye, C.A. (1995). The neurosteroid 3,5-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy. Brain Research 696, 113-120.

23

18. Crystal, S., Frye, C.A. & Kanarek, R.B. (1995). Taste preferences and sensory perceptions in female varsityswimmers. Appetite 24, 25-36.17. Frye, C.A. & Sturgis, J.D. (1995). Neurosteroids affect spatial/reference, working, and long-term memory of female rats. Neurobiology of Learning and Memory, 64, 83-96.16. Frye, C.A. (1995). Estrus-associated decrements in a water maze task are limited to acquisition. Physiology& Behavior, 57, 5-14.15. DeBold, J.F. & Frye, C.A. (1994). Genomic and non-genomic actions of progesterone in the control of female hamster sexual behavior. Hormones and Behavior 28, 445-453.14. DeBold, J.F. & Frye, C.A. (1994). Progesterone and the neural mechanisms of hamster sexual behavior.Psychoneuroendocrinology 19, 563-579.13. Frye, C.A., Crystal, S., Ward, K.D. & Kanarek, R.B. (1994). Menstrual cycle and dietary restraint influence taste preferences in young women. Physiology & Behavior 55, 561-567.12. Frye, C.A. & Weisberg, R.B. (1994). Increasing the incidence of routine pelvic examinations: BehavioralMedicine's contribution. Women and Health 21, 33-55.11. Frye, C.A. & Leadbetter, E.A. (1994). 5-reduced progesterone metabolites are essential in hamster VTA for sexual receptivity. Life Sciences 54, 653-659.10. Frye, C.A. & Duncan, J.E. (1994). Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats. Brain Research 643, 194-203.9. Frye, C.A. & DeMolar, G. (1994). Menstrual cycle and sex differences influence salt preference. Physiology& Behavior 55, 193-197.8. Frye, C.A., Mermelstein, P.G. & DeBold, J.F. (1993). Bicuculline infused into the hamster ventral tegmentum inhibits, while sodium valproate facilitates, sexual receptivity. Pharmacology, Biochemistry and Behavior 46, 1-87. Frye, C.A., Cuevas, C.A. & Kanarek, R.B. (1993). Diet and estrous cycle influence pain sensitivity in rats.Pharmacology, Biochemistry and Behavior 45, 255-260.6. Frye, C.A. & DeBold, J.F. (1993). 3-OH-DHP and 5-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus. Brain Research 612, 130-137.5. Frye, C.A. & DeBold, J.F. (1993). P-3-BSA, but not P-11-BSA, implants in the VTA rapidly facilitate receptivity in hamsters after progesterone priming to the VMH. Behavioral Brain Research 53, 167-175.4. Frye, C.A., Mermelstein, P.G., & DeBold, J.F. (1992). Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus. Brain Research 578, 87-93. [3. Frye, C.A., Bock, B.C. & Kanarek, R.B. (1992). Hormonal milieu affects tailflick latency in female rats and may be attenuated by access to sucrose. Physiology & Behavior 52, 699-706.2. Frye, C.A. & DeBold, J.F. (1992). Muscimol facilitates sexual receptivity in hamsters when infused into the ventral tegmentum. Pharmacology, Biochemistry & Behavior 42, 879-887.1. Frye, C.A. & Erskine, M.S. (1990). Influence of time of mating and paced copulation on induction of pseudopregnancy in cyclic female rats. Journals of Reproduction and Fertility 90, 375-385.

BOOK CHAPTERS22. Kohtz, A.S., Frye, C.A. (2012). Dissociating behavioral, autonomic, and neuroendocrine effects of androgen steroids in animal models. In: Psychiatric Disorders: Methods and Protocols, Editor: Firas Kobeissy, Ph.D., (in press). Springer.21. Walf , A.A., Frye, C.A. (2011). Object Recognition - The Role of Hormones Throughout the Lifespan,

24

Object Recognition, Tam Phuong Cao (Ed.). InTech. Chapter 2: 15-26.20. Frye, C.A., Llaneza, D.C. (2011). The role of 3α-hydroxy-5α-pregnan-20-one in mediating the development and/or expression of schizophrenia spectrum disorders: Findings in rodent models and clinical populations. In: Brain Protection in Schizophrenia, Mood and Cognitive Disorders, Editor: Michael Ritsner, M.D., Ph.D., Vol 1, 367-404. Springer.19. Walf, A.A., Frye, C.A. (2010). Using the elevated plus maze as a bioassay to assess the effects of naturally- occuring, and exogenously-administered compounds, to influence anxiety-related behaviors of mice. In: Mood & Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Editor: Todd Gould, M.D., 225-246. Springer Protocols.18. Frye, C.A. (2009). Neurosteroids-From Basic Research to Clinical Perspectives. In: Hormones/Behavior Relations of Clinical Importance. Editors: Robert T. Rubin and Donald W. Pfaff, 395-416. San Diego: Academic Press.17. Frye, C.A. & Rhodes, M.E. (2009). Female sex steroids and neuronal excitability. In: Encyclopedia of BasicEpilepsy Research.Volume 1. Editor: Phil Schwartzkroin, 477-484. Oxford: Academic Press.16. Frye, C.A. & Rhodes, M.E. (2009). Male sex steroids and neuronal excitability. In: Encyclopedia of BasicEpilepsy Research. Volume 1. Editor: Phil Schwartzkroin, 507-513. Oxford: Academic Press.15. Frye, C.A. (2008). Hormonal influences on seizures: Basic neurobiology. In: Epilepsy in women-scientific management. Editors: Barry Gidal and Cynthia Harding. International Review of Neurobiology, 83, 27-77.14. Frye, C.A., Rhodes, M.E. (2008). The role of midbrain 3α,5α-THP in mediating exploration, anxiety, social and reproductive behavior In: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Editors: Michael S. Ritsner and Abraham Weizman, 449-482, New York, NY, US: Springer Science.13. Frye, C.A., Rhodes, M.E. (2007). The role and mechanisms of steroid hormones to enhance approach/avoidance behavior. In: Handbook of approach and avoidance motivation. Editor: A. Elliot, 109-126, Mahwah, NJ: LEA.12. Frye, C.A., Rhodes, M.E. (2007). Reciprocal effects of exploration, anxiety, social, and sexual behaviors and progestins in midbrain, hippocampus, diencephalon, and cortex In: Evolutionary Molecular Strategies and Plasticity: Editors: Marcello Canonaco and Rosa Maria Facciolo, 237-260, Research Signpost.11. Harden, C.L. & Frye, C.A. (2007). Hormone Changes in Epilepsy. In: Epilepsy: A Comprehensive Textbook, Second Edition. Editors: Jerome Engel, M.D., Ph.D., Timothy A. Pedley, M.D., 2037-2042, Lippincott Williams & Wilkins.10. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., & Zupanc, M.L., eds. (2005). Epilepsy through the menstrual cycle: the truth about catamenial epilepsy. Neurology Supplement.9. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., Zupanc, M.L., eds. (2005). Correlations between hormone levels and seizure activity. Neurology Supplement.8. Frye, C.A., Harden, C.L., Baker, G. A., Montouris, G.D., Pennell, P.B., Zupanc, M.L., eds. (2005). Effects of estrogen and progesterone on cortical excitations and epileptogenesis Neurology Supplement.7. Frye, C. A., Petralia, S. M. (2003). 3,5-THP’s actions in the ventral tegmental area for lordosis: A model system for defining function and mechanisms of progestins. In: Neurosteroids and the GABAA Receptor. Editor: S. Smith, CRC Press, Boca Raton, FL.6. Frye, C.A., Petralia, S.M. (2003). Progestins have actions through GABAA receptors, In: The Identities of Membrane Steroid Receptors: And Other Proteins Mediating Nongenomic Steroid Action, Editor: C.S. Watson, Kluwer Academic Publishers, Boston, MA.5. Rhodes, M.E., Frye, C.A. (2002). Hormones influence cognitive performance, In: Forget it? -

25

Sources, Theories, and Mechanisms of Alterations in Mnemonic Function, Editor: R. Flint, Erudition Books, North Chelmsford, MA, 175-196.4. Frye, C.A., Weisberg, R.B., Hinkson, A.B. (2000). Anxiety and women's health. In: The management of stress and anxiety in medical disorders, Editors: D.I. Mostofsky and D.H. Barlow, Allyn & Bacon, Needham, MA. 378-396.3. Frye, C.A. (2000). Integration of affiliation: Well done! Trends in Endocrinology and Metabolism, 11, 155-157.2. Frye, C.A. (2000). Neurosteroids: A new regulatory function in the Nervous System. The Quarterly Review ofBiology, 75, 349-350.1. Smith, S.S., Hsu, F.C., Li, X., Frye, C.A., Faber, D.S., Markowitz, R.S. (2000). Oestrogen effects in olivo- cerebellar and hippocampal circuits. Neural and cognitive effects of oestrogens. Wiley, Chichester, 230, 155-172.

EDUCATIONAL REPORTS

9. McLaughlin, J.P., Gomes, S., Seliga, A., Ramos-Goyette, S., Morrison, A., Reich, C.G., Frye, C.A. (2009). Northeast Under/graduate Research Organization for Neuroscience (NEURON): our 13th conference for neuroscience trainees and educators. CBE-Life Sciences Education. The American Society for Cell Biology, 8, 111-3.8. Goyette, S.R., Edinger, K.L., Luine, V., Young, J., Frye, C.A. (2009). Northeast Under/graduate Research Organization for Neuroscience (NEURON): Our third New York City meeting. The Journal for Undergraduate Neuroscience Education, 6: A14-A20.7. Rhodes, M.E., Ramos, S.G., Young, J., Luine, V., Frye, C.A. (2008). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our twelfth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research, 6.6. Rhodes, M.R., Edinger, K.L., Smith, J., Luine, V., Frye, C.A. (2007). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research, 5: 1-8.5. Rhodes, M.E., Edinger, K.L., Young, J., Luine, V., Frye, C.A. (2006). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research. 4:1-7.4. Edinger, K.L., Smith, J., Luine, V., Frye, C.A. (2005). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our ninth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research, 2, 1-7.3. Frye, C.A., Edinger, K.L. (2004). Northeast Under/graduate Research Organization for Neuroscience (NEURON): A regional neuroscience meeting for undergraduates, graduate students, and faculty. Journal for Undergraduate Neuroscience Education, 2, 36-40.2. Edinger, K.L., Morgan, K., Blasberg, M., Frye, C.A. (2004). Northeast Under/graduate Research Organization for Neuroscience (NEURON): An update on our eighth annual conference for neuroscience trainees and educators. Journal of Behavioral and Neuroscience Research, 1, 1-8.1. Blasberg, M.E., Morgan, K., Frye, C.A. (2003). The 7th annual conference on the Northeast Under/graduateResearch Organization for Neuroscience (NEURON). Journal of Behavioral and Neuroscience Research, 1:1-2.

INVITED TALKSFrye, C.A. (2013). Pregane xeniobiotic receptor and membrane progestin receptors: sources and targets for

neurosteroid-mediated motivated behaviors. 7th Steroids and the Nervous System meeting, Torino, Italy.

26

Walf, A.A. & Frye, C.A. (2013). Finasteride increases depression behavior, whereas administration of 3-androstanediol can reduce depression behavior and increase brain-derived neurotrophic factor, without increasing prostate growth, of male mice. 7th Steroids and the Nervous System meeting, Torino, Italy.

Frye, C.A. (2012) Neurosteroids and neuroplasticity-an overview of research from our lab. University of Alaska, Fairbanks, AK.

Frye, C.A., Walf, A.A. (2012). Targeting hormone actions for therapeutic promise. Conference for Association forPharmacy and Therapeutics, University of Buffalo, NY.

Frye, C.A. (2012). Perinatal steroid action, preterm birth and health outcomes. Hotchkiss Brain Institute, University of Calgary, Canada.

Frye, C.A. (2012). Neurosteroids and social, affective, cognitive and neuroprotective processes. University ofAlaska, Fairbank.

Frye, C.A. (2012). Estrogen receptor beta. Brock University, Saint Catherines, Ontario, Canada.Frye, C.A. (2012). Neurosteroids and endogenous signaling in brain. Indiana University, Bloomington, IN.Frye, C.A. (2012). Hormones as therapeutic targets. Albany College of Pharmacy and Allied Health Sciences,

Albany, NY.Frye, C.A. (2012). Progesterone and aging. Tufts Center for Human Nutrition and Aging, Boston, MA.Frye, C.A. (2011). Hormone replacement therapy-promise and progress. American Heart Association Annual

Meeting, Orlando, FL.Frye, C.A. (2011). Progestogens...not just for pregnancy! University of North Carolina Medical School,

Department of Psychiatry, Chapel Hill, NC.Frye, C.A. (2011). Your brain and steroids: of, for, and by the nervous system. University of California, Santa

Barbara, California.Frye, C.A. (2011). Neurosteroids: Of, for, and by, the nervous system. Texas A&M University, College Station,

Texas.Frye, C.A. (2011). The role of neurosteroids in motivated behaviors. Universite de Strasbourg, Strasbourg,

France.Frye, C.A. (2011). The role of neuroactive steroids and depression. Neurex Workshop, Basel, Switzerland.Frye, C.A. (2011). Pregnane xenobiotic receptors in the ventral tegmental area may mediate progestogen-

facilitated reproductive behavior of female rats. Symposium presentation at the 6th International Meeting Steroids and Nervous System. Torino, Italy.

Frye, C.A. (2011). Effects and mechanisms of progestogens for object memory. Conference on Learning andMemory, Park City, Utah.

Frye, C.A. (2010). Progestogens’ and estrogens’ social, affective, and cognitive function. Nova SoutheasternUniversity & Ponce School of Medicine, Ponce, Puerto Rico.

Frye, C.A. (2010). Neurosteroids: Of, for, and by, the nervous system. Universidad del Este-SUAGM, Escuela deCiencias y Tecnologia, Carolina, Puerto Rico.

Frye, C.A. (2010). (Neuro)steroids of, for, and by the nervous system. Hudson-Berkshire Neuroscience Group,Albany, NY.

Frye, C.A., Paris, J.J., Walf, A.A. (2010). The role if pregnane neurosteroid formation in reproductive endocrine function and pregnancy. 4th International Parental Brain Meeting, Edinburgh, Scotland.

Frye, C.A. (2010) Protective effects of progesterone. 19th Annual Meeting, International BehavioralNeuroscience Society, Sardinia, Italy.

Frye, C.A. (2010) Sex, Drugs & Rock ‘n’ Roll. Neurofest, SUNY Upstate Medical Universtiy, Syracuse NY. Frye, C.A. (2010). Beneficial trophic effects in the brain relative to negative proliferative effects on peripheral

reproductive tissues. Window of Opportunity - Estrogen Workshop, Stanford, CA.Frye, C.A. (2009). Sex, Drugs, Rock & Roll, The Role of Neurosteroids 17th New England Conference

North/East Under/graduate Research Organization for Neuroscience (N.E.U.R.O.N.), Boston Latin School, Boston, MA.

Giordano M., Caljouw, M., McCarthy, M., Scapicchio, P., Spillane, T., Frye, C.A. (2009). Doctors, Lawyers, &

27

Chiefs. Boston Latin School, Boston, MA.Frye, C.A. (2009). Distinguished Graduate Award Talk. Boston Latin School Alumni Dinner, Boston, MA. Frye, C.A. (2009). Neurodegenerative Disorders. Boston Latin School, Boston, MA. Frye, C.A. (2009). Progesterone: novel effects and mechanisms across the lifespan. Indiana State University, Bloomfield, IN.Frye, C.A. (2009). Sex differences in HPA-responding and the role of progestogens in adult expression and

development of stress responses. State University of New York, School of Public Health, Albany, NY.Frye, C.A. (2009). Neurosteroids’ effects and mechanisms for social, cognitive, emotional, and physical functions.

Arizona State University.Frye, C.A. (2009). Progesterone and its metabolites in the pathophysiology and treatment of neuro-

developmental, psychiatric and/or developmental disorders. 11th Argentinean Congress of Neuropsychiatry Conference. Argentina.

Frye, C.A. (2009). Estrogens, progestogens and androgens… oh my: effects and mechanisms for depression.International Society for Psychoneuroendocrinology Conference 2009. San Francisco, California.

Walf, A.A. & Frye, C.A. (2009). Estradiol’s actions through estrogen receptor β for functional effects in hippocampus-mediated behaviors, but not uterine proliferation or carcinogen-induced tumorigenesis. International Behavioral Neuroscience Society, 18th Annual Meeting, Nassau, Bahamas.

Frye, C.A., Paris, J.J., Franco, C., Sodano, R., Freidenberg, B., Forsyth, J.P., Anderson, D.A., Wulfert E. (2009).Sex differences in stress hormone response are not always male-biased in panic disorder symptomology, posttraumatic stress disorder, & pathological gambling. Satellite symposium presentation at the 5th International Meeting Steroids and Nervous System. Torino, Italy.

Frye, C.A., Llaneza, D.C., Paris, J.J. (2009). Activational and organizational effects of progesterone for affective and cognitive behavior due to 5-pregnan-3-ol-20-one. Symposium presentation at the 5th

International Meeting Steroids and Nervous System. Torino, Italy.Frye, C.A. (2009). ERβ is a target for beneficial trophic effects of estrogens in females, and androgens in males, in

brain but not reproductive tissue. New York Medical College. New York, NY.Frye, C.A. (2009). Sex, drugs, and rock n’ roll: the role of neurosteroids. Northeastern University.Frye, C.A., Llaneza, D.C., Paris, J.J. (2009) Activational and organizational effects of progesterone for

affective and cognitive behavior due to 5α-pregnan-3α-ol-20-one. Conference on Steroids and the Nervous System. Torino, Italy.

Paris J.J., Frye C.A. (2009) Formation of 3α-androstanediol may underlie alcoholpromoted aggression among rodents. Conference on Steroids and the Nervous System. Torino, Italy.

Frye, C.A. (2008). The role of actions at the β isofrom of the estrogen receptor in mediating affective behavior.International Congress of Neuropsychiatry, Cancun, Mexico.

Walf, A.A., Frye, C.A. (2008). ER may be a novel target for the beneficial effects of naturally-occurring steroids, therapeutics, and selective estrogen receptor modulators. International Drug Discovery Science and Technology, Beijing, China.

Frye, C.A., Walf, A.A. (2008). ER may be a novel target for the beneficial effects of estrogens in females, and androgens in males, for anxiety, depression, and cognitive function. Ehrlich II- 2nd World Conference on Magic Bullets, Nurnberg, Germany.

Frye, C.A. (2008). Progesterone… it’s not just for pregnancy. Louisiana State University, Shreveport, LA.Frye, C.A. (2008). Enhancing children’s neural and cognitive development through reading. Delaware Community

School, Albany, NY.Frye, C.A. (2008). The role of actions at ERβ in beneficial effects of estrogens and progestins. Organization

for the study of sex differences conference, New Orleans, LA.Frye, C.A. (2008). The role of neurosteroids and actions at ERβ for physical and psychology effects of hormone

therapies. Wyeth Pharmaceuticals, Collegeville, PA.Frye, C.A. (2008). Progestogens...of, for, and by the nervous system are not just for pregnancy. Drexel University

28

Medical School, Pharmacology Department, Philadelphia, PA.Frye, C.A. (2008). Steroid hormones in mental health and disease. International Congress of

Neuropsychiatry, Cancun MexicoFrye, C.A., Walf, A.A. (2008). Estrogen receptor β as a target for the anti-anxiety and anti-depressant effects

of steroids Conference of The Society for The Study of Sex Diffferences, New Orleans, LA.Frye, C.A., (2008). Functional effects of neurosteroids-hormones that are of the nervous

system, by the nervous system, and for the nervous system. Albert Einstein School of Medicine, Bronx, NYFrye, C.A., (2007). Estrogen receptor β as a target for steroids’ effects on affective and cognitive behavior. Annual

Graylyn Conference on Women's Cognitive Health, Wake Forest, NC.Frye, C.A., (2007). Progestins actions in the midbrain to enhance lordosis involve GABA, dopamine

and glutamate receptors and their downstream signal transduction factors. Conference on Rapid Response Signaling of Steroid Hormones, Dublin, Ireland.

Frye, C.A., (2007). Neurosteroids- Of the nervous system, by the nervous system, for the nervous system.Skidmore College, Saratoga Springs, NY.

Frye, C.A., Walf, A.A. (2007). Actions at estrogen receptor may underlie some of the anti-anxiety, anti- depressant, and memory enhancing effects of steroids. Conference on Steroids and the Nervous System. Torino, Italy.

Frye, C.A.(2007). The global impact of behavioral endocrinology-hormones across the world.. Conference onSteroids and the Nervous System. Torino, Italy.

Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Inhibition of 3,5-THP formation decreases exploratory/anti- anxiety and socio-sexual behavior in sexually receptive female rats. Conference on Steroids and the Nervous System. Torino, Italy.

Frye, C.A., Paris, J.J. (2006). 3-androstanediol may underlie some of testosterone’s positive hedonic and/or drug-related effects. International Society for Biomedical Research on Alcoholism -World Congress on Alcohol Research, Sydney, Australia.

Frye, C.A., Walf, A.A. (2006). Anti-anxiety and anti-depressant effects of steroids with actions at estrogen receptor . 37th Annual International Society for Psychoneuroendocrinology (ISPNE) meeting. Leiden, Netherlands.

Frye, C. A. (2006). Effects of pre-natal manipulations on response to stress during development and in adulthood.Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders,Morzine, France.

Frye, C.A. (2006). Rewarding effects of progestins: Importance for drug abuse. Pharmacology, Biochemistry andBehavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France.

Rhodes, M.E., Frye, C.A. (2006). Rewarding effects of androgen: Importance for drug abuse. Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France.

Walf, A.A., Frye, C.A. (2006). Antidepressant-like effects of estrogen receptor modulators after short-termtreatment. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France.

Walf, A.A., Rhodes M.E., Frye, C.A. (2006). Rewarding effects of estrogen: Importance for drug abuse. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France.Frye, C.A. (2005). Ovarian hormones in animal models of catamenial epilepsy. Special Interest Group – Animal

Models of Catamenial Epilepsy at the American Epilepsy Society Meeting, Washington, DC.Frye, C.A. (2005). Differential behavioral effects of estradiol through ER and ER. National Academy of

Sciences of the Czech Republic, Prague, Czech Republic.Frye, C.A. (2005). Role of progesterone in animal models of schizophrenia. Prague Center for Psychiatry,

Prague, Czech Republic.Petralia, S. M., Sumida, K., & Walf, A. A., Frye, C. A. (2005). Progestin-facilitated sexual behavior of female

rats may involve activity of adenylyl cyclase in the ventral tegmental area (VTA). International Conference

29

on Steroids and the Nervous System, Torino, Italy.Rhodes, M. E., Petralia, S.M., Jahagirdar, V., & Frye, C. A. (2005). Actions of the neurosteroids, 3, 5-THP,

in the ventral tegmental area, mediate socio-sexual behaviors. International Conference on Steroids and the Nervous System, Torino, Italy.

Frye, C.A. & Rhodes, M.E. (2004). Ovarian hormones and their effects on cortical excitation and influences on epileptogenesis. Women and Epilepsy Advisory Board, Atlanta, GA.

Frye, C.A. (2004). Sex differences in rats: anxiety responses to androgens, Pharmacology, Biochemistry andBehavior Conference, Morzine, France.

Frye, C.A. & Rhodes, M.E. (2003). Androgens and seizures. American Epilepsy Society Conference, Boston, MA. Frye, C.A. (2003). Novel actions of steroid hormones- basic and clinical research. Marywood University,

Scranton, PA.Frye, C.A. (2003). Membrane actions of hormones and the relationship to function. Marywood University,

Scranton, PA.Frye, C.A. (2003). Approaches to enhance training of neuroscience. International Brain Research

Organization, Prague, CZ.Frye, C.A. (2003). Sex and hormonal differences in response to gestational stress. TENNET Conference,

Montreal, CANADA.Frye, C.A. (2003). The functional role of neurosteroids. CUNY-Park Avenue Colloquium, New York City, NY.Frye, C.A., Petralia, S., & Rhodes, M.E. (2003). Fluoxetine’s effects on sexual function may involve

allopregnanolone in the ventral tegmental area. International Conference on Steroids and the Nervous System, Torino, Italy.

Frye, C.A. (2003). Non-ER mediated effects of estrogen on learning and memory. Experimental Biology Meeting, San Diego, CA.

Frye, C.A. & Rhodes, M.E. (2003). Estrogen may have genomic and non-genomic actions in the dorsal hippocampus to improve inhibitory avoidance performance. Twenty-seventh Annual Winter Conference on the Neurobiology of Learning & Memory at Park City, Park City, UT.

Frye, C.A. (2002). The role of non-genomic actions of steroids in mediating reproductive, affective and cognitive behaviors. CUNY-Brooklyn, Psychology Department Colloquia.

Frye, C.A. (2002). Mating-induced neurosteroidogenesis in the hippocampus induces anxiolysis of female rats.Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.

Frye, C.A. & Epperson, N. (2002). Neurosteroid modulation of -Aminobutyric Acid neuronal function: Clinical implications. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.

Herzog, A.G., Frye, C.A., Drislane, F.W., Friedman, M.N., & Schomer, D.L. (2001). Neuroactive reproductive steroid changes in men with epilepsy: associations with sexual function and potential implications for neuronal excitability. American Epilepsy Society Conference, Philadelphia, PA.

Frye, C.A. (2001). Non-genomic actions of steroid hormones mediate social, affective, and cognitive behaviorAmerican College of Neuropsychopharmacology. Waikoloa, Hawaii.

Frye, C.A. (2001). Developing Programs in Neuroscience at the Small College and University, NSF Sponsored Project Kaleidoscope Workshop on “Neuroscience Education: From the Enchanted Loom to the World Wide Web”, Hartford, Connecticut.

Frye, C.A. (2001). North East Undergraduate Research Organization for Neuroscience (N.E.U.R.O.N.), A regional program to promote training in Neuroscience Undergraduate. NSF Sponsored Project KaleidoscopeWorkshop on “Neuroscience Education: From the Enchanted Loom to the World Wide Web”, Hartford, CT.

Frye, C.A. (2001). Distinguishing allopregnanolone’s effects on anxiety from other behaviors. AmericanNeuroendocrine Society Conference, Breckenridge, Co.

Frye, C.A. (2001). Neurosteroids and anxiety. Symposium Organizer and Chair, American NeuroendocrineSociety Conference, Breckenridge, Co.

Frye, C.A. (2001). Neurosteroids actions in modulating reproductive and non-reproductive behavior.Neuroscience Symposium Series, Brigham Young University, Provo, Utah.

30

Frye, C.A. & Muscatiello, N. (2001). The mechanism of action of progestins’ anti-seizure effects in the hindbrain.Workshop on the Neurobiology of Epilepsy, Iguazu, Brazil.

Frye, C.A. (2001). 3,5-THP in the raphe nucleus and pontine reticular formation attenuate myoclonic and tonic clonic seizures. Spring Epilepsy Research Conference, Grand Cayman, BWI.

Frye, C.A. (2001). Assessing factors which influence anti-seizure effects of neurosteroids: Integration of basic andclinical research. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.

Frye, C.A. (2001). The role of NMDA receptors in the VTA in mediating progestin-facilitated sexual receptivity.Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.

Frye, C.A. (2001). How do steroids mitigate sex, anxiety, learning and memory, and brain damage? LaDonneHeaton Schulman Endowed Lecture, Wheaton College, Norton, MA.

Frye, C.A. (2001). The role of androstane neurosteroids in mediating reproductive and non-reproductive behavior.Neuroendocrinology Colloquium Series, The University of Milan, Italy.

Frye, C.A. (2001). Factors which influence sexual differentiation by environmental endocrine disruptors-using reproductive and non-reproductive behavior as indicators. The Department of Animal Sciences, The University of Florence, Italy.

Frye, C.A. (2001). Neurosteroids in the Ventral Tegmental Area mediate sexual receptivity in rodents.International Conference on Steroids and the Nervous System, Torino, Italy.

Frye, C.A. (2000). Two interactive exercises which engage students to learn about the brain. Eastern SectionSiena State Teachers’ Conference, Albany, NY.

Frye, C.A. (2000). What can progesterone’s actions for sex behavior in rodents tell us about neural substrates for learning and memory, anxiety and neuroprotection in people? The College of Saint Rose, Albany, NY.

Frye, C.A. (2000). Neurosteroids mediate the onset and duration of sexual receptivity in rodents. Society forBehavioral Neuroendocrinology, Madrid, Spain.

Frye, C.A. (2000). Neurosteroids …Of the Nervous system, by the Nervous System and for the Nervous System.Society for Behavioral Neuroendocrinology, Madrid, Spain

Frye, C.A. , Rhodes, M.E., Spataro, L.E. (2000). The role of neurosteroids in the Ventral Tegmental Area in mediating sexual receptivity in rodents. Society for Behavioral Neuroendocrinology, Madrid, Spain.

Frye, C.A., Petralia, S., & Rhodes, M.R. (2000). Sex and estrous cycle differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3,5-THP. Biological Basis of Sexual Orientation, Sex Identity, and Gender-Typical Behavior. Minot, North Dakota.

Frye, C.A. (1999). Non-genomic actions of progestins on cognitive and affective behavior in rodents. The keynote address for National Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico.

Frye, C.A. (1999). Non-genomic actions of progesterone in the VTA-effects on sexual receptivity. NationalCongress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico.

Frye, C.A. & J.M. Vongher. (1999). The role of 3,5-THP in progesterone’s facilitation of sexual receptivity inmice. International Behavioral Neuroscience Conference, Nancy, France.

Frye, C.A. (1999). Neurosteroids role in progestins' anti-seizure effects. Spring Epilepsy Research Conference, Grand Cayman, BWI.

Frye, C.A. (1999). Neurosteroids & behavior. European Winter Conference on Brain Research, Aime, France. Frye, C.A. (1999). The role of neurosteroids in social behavior. European Winter Conference on Brain Research, Aime, France.Frye, C.A. (1999). Non-genomic actions of steroid hormones...functional consequences. Hudson-Berkshire

Neuroscience Group, Albany, New York.Frye, C.A. (1998). Progestins mediate reproductive and non-reproductive behavior. The University at

Albany- SUNY, Albany, NY.Frye, C.A. (1998). Neurosteroids mediate sexual, cognitive, and affective behavior. Emory University,

Atlanta, GA.Frye, C.A. (1998). The role of steroid hormones in neurodegenerative disorders. Centenary College/Louisiana

State University, Shreveport, LA.

Introductory Psychology (U) Psychology as a Natural Science (U)Experimental Psychology (U) Research Methods in Human Development (U)Motivation and Emotion (U) Brain, Mind and Behavior (G)Physiological Psychology (U & G) Behavioral Neuroscience (U & G)Advanced Behavioral Neuroscience (G) Neurobiology (G)Seminar in Behavioral Neuroscience (U & G) Behavioral Endocrinology (U & G)Hormones and Behavior (U & G) Psychopharmacology (U & G)Stress (U,G) Honors College Proposal Practicum in Neuroscience (U & G)Individual Study (U) Dissertation (G)

31

Frye, C.A. (1998). Progesterone’s mechanism of action. Georgia State University, Atlanta, GA. Frye, C.A. (1998). Neurosteroids and motivated behavior. Florida State University, Gainesville, FL.

Frye, C.A. (1997). Progestins role in epilepsy. Epilepsy Foundation of America Regional Meeting. Darien, CT. Frye, C.A. (1997). Non-genomic effects of progesterone - Implications for PMS, Epilepsy and Alzheimer’s

Disease. Rutgers University, Camden, NJ.Frye, C.A. (1996). Neurosteroids role in reproductive and non-reproductive behavior. University of Southern

Florida, Tampa, FL.Frye, C.A. (1996). Alzheimer’s disease: a focus on effects of hormones. Alleghany College, Alleghany, PA. Frye, C.A. (1996). Progestin mechanism of action; effects on reproductive and non-reproductive behavior.

LeHigh University, Bethlehem, PA.Frye, C.A. (1995). Hormonally mediated taste preference - caveats and qualifications. Eastern Psychological

Association, Boston, MA.Frye, C.A. (1995). The functional role of neurosteroids: Animal and human studies. Symposium chair and

speaker, Winter Brain Conference, Steamboat Springs, CO.Frye, C.A. (1994). Androgens actions to inhibit sexual receptivity are non-genomic. Workshop on Steroid

Hormones and Brain Function, Breckenridge, Co.Frye, C.A. (1994). Non-genomic steroid effects relevant for reproduction. Symposium chair and speaker,

Conference on Reproductive Behavior, LeHigh Valley, PA.Frye, C.A. (1993). Mk-801 and nimodipine: Neuroprotective effects may not extend to behavior. Cambridge

Neuroscience, Cambridge, MA.

COURSES TAUGHT(U=undergraduate course, G=graduate course)

SOCIETIES, MEMBERSHIPS & AFFILIATIONS

American Association for the Advancement of Science 1990-1996American Neuroendocrine Society 1998-presentAmerican Psychological Society 1991-1997Developmental Psychobiology 1997-2001Endocrine Society 1995-presentInternational Behavioral Neuroscience Society 1995-2005North East Under/graduate Research Organization for Neuroscience(N.E.U.R.O.N., Co-Founder & Executive Steering Committee Member)

1996-present

Sigma Xi, Research Honor Society 1991-1998Society for Behavioral Neuroendocrinology 1995-presentSociety for Ingestive Behavior 1992-2002Society for Menstrual Cycle Research 1992-1996

32

Society for Neuroscience 1989-present

33

GRADUATE STUDENT/POST DOC ADVISEES

Student Institution Advised At Current Affiliation/PositionLaura Bayon, MD Connecticut College Saint Luke's Family Care Clinic

PediatricsElizabeth Lacey, MS Connecticut College Georgetown UniversityRebecca Murphy, MS Connecticut College PfizerJill Vongher, PhD Connecticut College UChicagoIrene Chin, MS SUNY Albany U Puget SoundJames Driscoll, MS SUNY Albany PfizerKassandra Edinger, MS SUNY Albany Tutor in Albany-areaFabiola Estrada, MS SUNY Albany SUNY AlbanyLauren Farnbach SUNY Albany Arizona State UniversityJeff Grizzaffi, MS SUNY Albany Troy Regional High SchoolVaishali Jahagirdar, PhD SUNY Albany SUNY AlbanyAmy Kohtz, MS SUNY Albany SUNY AlbanyDanielle Llaneza, MS SUNY Albany SUNY Albany /Scripps, FLNeil Muscatiello, MS SUNY Albany NY State Dept of HealthDanielle Osborne, MS SUNY Albany SUNY AlbanyJason Paris, Ph.D. SUNY Albany Torrey PinesSandra Petralia, PhD SUNY Albany TaconicSteven Platek, Ph.D. SUNY Albany Georgia Gwinnett CollegeMadeline Rhodes, PhD SUNY Albany McDaniel CollegeKyungok Sim, Ph.D. SUNY Albany U TexasKanako Sumida, MS SUNY Albany UAlbany, Of. Research ComplianceAlicia Walf, PhD SUNY Albany Rensselaer Polytechnic Institute

UNDERGRADUATE STUDENTS SUPERVISED (* indicates students that co-authored publications)

Chris AcerJason Ackerman Arlene Adams Dana Alvarez Allison Arneill Lyndsey Avalone Alicia Babson* Laura Bayon* Sheena Ballard Alysha Binon Matt BlackmanTheresa Blakesley Dana Braseth Jennaye Brown Damali Carrington Brian Carroll

Christina Castro Madison Chester Annie Cheung Lesley ColePeter Copeland* Candice Crain Caitlin Crowley Susan Crystal* Carlos Cuevas* Patricia Currier Daniel Cusher Daniel DaCostaSangha Dalimbkar Abigail Davidson Errene Delnevo Allyson Delprino

Trisha Diamond Johanna Diaz Eleni Dimitriadis Luigi DiRienzo Lauren Doherty James Driscoll Jennifer Duncan* Jeffrey Duqette Caryn Duffy*Kassandra Edinger* Dana EriccoKate Fagan-Solis Kristin Fields Digna Figeuroa Alyssa Fluty* Nicole Frederick

Jonathan Friedman Jennifer Gallagher Dario GarciaSara Gardiner* Amy Gazzara Rita German Melissa Gnech Jeremy Gold Taylor Goldberg Barbara Graham Jeff Grizzaffi Gloria GuptillRebecca Habernig Fareed Haddad James Hanks Emily Hey

2

Bushra Helmandi Nicole Hercules Tom Herman Janet Heuring Megan HickeyMichael Horlacher Pascale Houanche Shannon Jeddi Michelle Jolicoeur Christina Joseph Oreisha Jordan Julia KeeneRyan KellerKendall van Keuran* Seehee KimAmy Kohtz* Carolyn Koonce* Kyana Kylek Elizabeth Lacey* Scott Lamm Nicolas LapisElizabeth Leadbetter* Bomi Lee*Bryan LicataJuan LinDanielle Llaneza* Mayulie Luciano

John Lusins Niclas Luongo Tara Mahar Soobin MaengJennifer Marrone* Jacob Martinez Jim McDonaldStephanie McKnight Frances Melendez Elana Mendelson Paul Mermelstein* John MerrimanAshley Morelli Amy Morrison Laura Murray Eric Olson Ryan O’Mara Zoe Orecki* Romae Palmer David Park* Aarat Patel Anne PlautKathy Prevost Neena Pursnani* Marie Rafalski Tinisha Ransome Trent Reed*

Eric RistEmily Roberge John Roberts Allicia Ryan* Kristin Sanderson* Nith Sanikone Anthony Santarelli Vanessa Sarfoh Trudy Scalise* Samantha Schmidt Nicole Schmitt Angela Seliga* Aaron Sheppard Jennifer Shorten Zachary Simpsom Andrew Slater Kylie SmallAlex Smith April Smith Emer Smith David Spangler Laurie Spofford Darcy Spitzer Leanna Stager Tara StankoBrittany StebbinsMathew St. Pierre

Ben Stein* Robert Steger Jodi Sturgis* Kanako Sumida* Masako Tanaka* David Tedeschi Sally Tetrault Sheri Thayil Hericka Torres Khristina Ulmer Mary UngerJana Vanderslice- BarrChris Voets Taryn Walcott Alicia Walf* Chris WalshJoanna Wawrzycki* Risa Weisberg* Samuel WilkenJari Willing Chris Wilming Boris YagudaStephanie YoumansSephehr ZandiEric Zho

32

COMMITTEES SERVEDI nst i tu t ion L e v e l of Co m m i t t e e Role Y ea rs Tufts University Department Colloquium Committee 1989/1990

Department Animal Use & Care 1990/1991Campus Sigma Xi, Research Honor Society 1991/1992Local Boston Area Neuroscience Gathering 1990-1992National Conference Committee for Soc. Ingestive Behavior 1991/1992

Bates College Department Search Committee for Social Psychologist 1992/1993Campus Sigma Xi, Research Honor Society 1992/1993Campus Howard Hughes Grant Committee 1992/1993Local Boston Area Neuroscience Gathering 1992/1993

Boston Univ. Departmental Colloquium Committee 1993/1994Campus Sigma Xi, Research Honor Society, Secretary 1993-1995Local Boston Area Neuroscience Gathering 1993-1995Regional New England Consortium for Undergraduate 1993-1995

Science EducationInternational Local Organizing Committee Society for Behavioral 1994/1995

NeuroendocrinologyConnecticut Department Laboratory and Animal Facility Coordinator 1995/1996College Department Colloquium Committee Coordinator 1996/1997

Campus Director of Neuroscience 1995-1997Campus Animal Care & Use Committee 1995-1997Campus Research Committee, Chair 1996-1997Campus Howard Hughes Grant Committee 1995/1996Campus Psi Chi, Psychology Honor Society 1995/1996Campus Study Abroad/Teach Abroad 1995-1997Local Boston Area Neuroscience Gathering 1995-1998Local Brain Awareness Week 1995-1998Regional North East Under/graduate Research Organization 1995/1998

for NeuroscienceNational Connecticut College’s Alumnae Outreach 1995/1996

SUNY Albany Department Search Committee for Behavioral Neuroscience 1998-2000Faculty (co-chair 99/00)

Department Search Committee for Social Psychology Faculty 2001-2001Department Honors Committee 1999-2009Department Colloquium Committee 2000-2007, 2009Department Social Committee 2000-2007, 2009

Campus Search Committee for Radiation Safety Officer 1999, 2001Campus Radiation Safety Committee 1999-presentCampus Research Facilities Implementation Comm 2000-2001Campus College Council 1999-2001Campus Animal Facility User Committee 2000-2001Campus Life Science Building Advisory Committee 2003-2009Campus Research Council 2004-2006Campus Researchers’ Liason Committee (co-chair) 2006-2009Local Brain Awareness Week 1998-presentRegional N.E.U.R.O.N., President 1998-present

32

International International Behavioral NeuroscienceSociety 2000-2002Membership Committee

International Program Committee- Steroids & Nervous System 2002-presentConference

International Program Committee- Pharmacology Biochemistry 2003-present& Behavior Conference