1

CURRICULUM VITAE

ROBERT S. BISCUP, M.S., D.O., F.A.O.A.O.

5601 N Dixie Highway Suite 306

Fort Lauderdale, FL 33334 954-355-4088

954-355-4089 (fax)

biscup@biscupspine.com

FORMAL EDUCATION 1970-1974 Hiram College Hiram, Ohio Bachelor of Arts 1974-1976 Case Western Reserve University Cleveland, Ohio Master's of Science, Health Sciences Education 1976-1980 Ohio University College of Osteopathic Medicine Athens, Ohio Doctorate of Osteopathic Medicine HONORS 1974 Cum Laude Hiram College Hiram, Ohio 1974 Departmental Honors, Chemistry Hiram College Hiram, Ohio 1975 Graduate Assistantship, Medical Education Case Western Reserve University School of Medicine Cleveland, Ohio

2

LICENSURE, CREDENTIALS, AND CERTIFICATION Medical Licensure: Doctor of Osteopathic Medicine, Florida, USA Active – Current, OS 8812 October, 2002 Doctor of Osteopathic Medicine, Ohio, USA Active - Current, # 34-00-3139 July, 1981 Practice of Medicine, Colorado, USA Inactive - Current, #35888 March, 1997 Board Certification: American Osteopathic Board of Orthopedic Surgery Certificate #: 137 March, 1989 Fellowship: Fellow, American Osteopathic Academy of Orthopedics (FAOAO) September, 1995 Awards: Patient Advocacy Award, American Academy of Pain Management March, 2002 Outstanding Educator Award, Orthopaedic Residency Training Program, Cleveland Clinic Foundation, Cleveland, OH June, 2002 Medal of Merit Award, Ohio University College of Osteopathic Medicine October, 2005 Medal of Merit Award, Ohio University Alumni Association October, 2007 PROFESSIONAL EXPERIENCE

3

July, 1985 - June, 1987 Kolczun & Kolczun Orthopedic Associates 5800 Cooper Foster Park Lorain, OH 44152 July, 1985 - June, 1991 Active staff Orthopedic Surgery Lorain Community Hospital 3700 Kolbe Rd Lorain, Ohio 44152 July, 1991 - June, 1997 Courtesy Staff Orthopedic Surgery Lorain Community Hospital 3700 Kolbe Rd Lorain, Ohio 44152 July, 1987 - May, 1990 Temporary Active Staff St. Vincent Charity Hospital 2351 East 22nd Street Cleveland, Ohio 44115 May, 1990 - June, 1997 Courtesy Orthopedic Surgery St. Vincent Charity Hospital 2351 East 22nd Street Cleveland, Ohio 44115 July, 1987 - June, 1997 Horizon Orthopedic, Inc. 2709 Franklin Blvd Cleveland, OH 44113 March, 1988 - June, 1997 Active Staff Orthopedic Surgery Lutheran Medical Center 2609 Franklin Blvd Cleveland, Ohio 44113 July, 1996 - June, 1997 Active Staff Department of Surgery Southwest General Hospital 18697 Bagly Rd Middleburg Hts, Ohio 44130 July, 1997 – August, 1997 Western Orthopedics & Sports Medicine 2020 North 12th Street Grand Junction, CO 81501

4

July, 1997 – August, 1997 Active Staff (provisional) Community Hospital 2021 North 12th Street Grand Junction, CO 81501 September, 1997 – Present Active Staff Cleveland Clinic Foundation Department of Orthopaedic Surgery, A-41 9500 Euclid Avenue Cleveland, OH 44195 January, 2003 – June, 2007 Active Staff Cleveland Clinic Florida Weston & Naples, FL 2950 Cleveland Clinic Blvd. Weston, Florida 33331 July, 2007 – Present Actice Staff Holy Cross Hospital & Medical Center Fort Lauderdale, FL 33301 ACADEMIC EXPERIENCE 1989 - June, 1997 Director, Medical Education Horizon Orthopedic 2709 Franklin Blvd. Cleveland, Ohio 44113 1989 - June, 1997 Director, Fellowship Training Program in Spinal Surgery Horizon Orthopedic / Lutheran Medical Center 2709 Franklin Blvd. Cleveland, Ohio 44113 1991 - 1995 President, American Osteopathic Academy of Orthopedics Section on Spinal Surgery 1993 - present Senior Examiner, American Osteopathic Board of Orthopedic Surgery 1991 - June, 1997 Orthopedic Consultant Cleveland Indians Professional Baseball Club 1995 - 2002 Clinical Professor in Orthopedic Surgery Ohio University College of Osteopathic Medicine 1999 – 2002 Director, Regional Spine Care Program

5

Cleveland Clinic Foundation 1999 – 2002 Director, National Center for Revision Spine Surgery Cleveland Clinic Foundation 2003 – June, 2007 Program Director, Spine Clinical Fellowship Program Cleveland Clinic Florida 2003 – June, 2007 Chairman, Cleveland Clinic Florida Spine Institute Cleveland Clinic Florida July 1, 2007 – Present President and Executive Director Biscup Spine INTERNSHIP, RESIDENCY, AND SPECIALTY TRAINING 7/1/80 - 6/30/81 Internship - Rotating Service 4110 Warrensville Center Road Meridia South Pointe Hospital (Formerly Brentwood Hospital) Warrensville Heights, Ohio 44122 7/1/81 - 6/30/85 Orthopaedic Surgery Residency Edward L. Andrews, D.O., Director 4110 Warrensville Center Road Meridia South Pointe Hospital (Formerly Brentwood Hospital) Cleveland, Ohio 44122 7/1/83 - 10/30/83 Basic Science & Orthopaedic Oncology John Makely, M.D. University Hospitals of Cleveland Cleveland, Ohio 44195 1/1/84 - 4/30/84 Adult Reconstructive Spinal Surgery Arthur D. Steffee, M.D. St. Vincent Charity Hospital Cleveland, Ohio 44115 7/1/85 - 12/31/87 Preceptorship Spinal Surgery Arthur D. Steffee, M.D. St. Vincent Charity Hospital Cleveland, Ohio 44115 PUBLICATIONS

6

1. A.D. Steffee, M.D., R. S. Biscup, D.O., and D. J. Sitkowski, P.A.-C., "Segmental Spine Plates with

Pedicle Screw Fixation." Clinical Orthopaedics and Related Research 203: 45, 1986. 2. N. Ani, M.D., L. Keppler, M.D., R.S. Biscup, D.O., and A.D. Steffee, M.D., "Reduction of High-

Grade Slips (Grades III-V) with VSP Instrumentation. Report of a Series of 41 Cases." Spine:16 (6), S302, 1991.

3. J.W. Brantigan, M.D., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., and P. Enker, M.D.,

"Posterior Lumbar Interbody Fusion Technique Using the Variable Screw Placement Spinal Fixation System." Spine - State of the Art Reviews: 6 (1), 175, 1992.

4. P. Enker, M.D., A.D. Steffee, M.D., C. McMillin, Ph.D., L. Keppler, M.D., R. Biscup, D.O., S. Miller,

D.O. "Artificial Disc Replacement: Preliminary Report with a 3 year minimum follow-up” Spine: 18 (8), 1061, 1993.

5. S.M. Lehmer, M.D., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., P. Enker, M.D., S.D.

Miller, D.O., R.W. Gaines, Jr., M.D., "Treatment of L5-S1 Spondyloptosis by Staged L5 Resection with Reduction and Fusion of L4 onto S1 (Gaines Procedure)." Spine: 19 (17), 1916, 1994.

7. S.M. Lehmer, M.D., L. Keppler, M.D., R.S. Biscup, D.O., P. Enker, M.D., S.D. Miller, D.O., A.D.

Steffee, M.D., "Posterior Transvertebral Osteotomy for Adult Thoracolumbar Kyphosis." Spine:19 (18), 2060, 1994.

8. D.R. Sybert, D.O., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., P. Enker, M.D.,

“Seven-Year Follow-up of Vertebral Excision and Reconstruction for Malignant Hemangioendothelioma of Bone: Spine: 20 (7), 841, 1995.

9. A.D. Steffee, M.D. & R.S. Biscup, D.O., “Metastatic Tumor Resection and Vertebrectomy: A

Posterior Lateral Approach in the Thoracic and Lumbar Spine” Spine-State of the Art Review: 10 (1), 113, 1996.

10. L. Keppler, M.D., A.D. Steffee, M.D., & R.S. Biscup, D.O., “Posterior Lumbar Interbody Fusion with

Variable Screw Placement and Isola Instrumentation”. In Bridwell K, DeWald R (eds). The Textbook of Spinal Surgery, Philadeplphia, Lippincott-Raven, 1997.

11. Podichetty V, Biscup RS. e-health: A New Approach in Healthcare practices. The Internet Journal

of Allied Health Sciences and Practice. July 2003; Vol 1. (2)

12. Issacs RE, Podichetty V, Biscup RS. Microendoscopic discectomy for recurrent disc herniations. Neurosurgery Focus. Sept 2003;15 (3):11

13. Podichetty V, Mazanec DJ, Biscup RS. Chronic Non-Malignant Musculoskeletal Pain in Older Adult: Clinical Issues and Opioid Intervention. Postgrad Med J. Nov’ 2003; 79: 627-633

14. Isaacs R, Podichetty VK, Santiago P, Sandhu FA, Spears J, Biscup RS. Minimally Invasive microendoscopy-assisted transforaminal lumbar Interbody fusion with instrumentation. J Neurosurgery: Spine. August 2005;3:98-105

7

15. Podichetty VK, Booher J, Whitfield M, Biscup RS. Assessment of Internet use and effects among healthcare professionals: a cross sectional survey. Postgrad Med J. April 2006;82:274-279

16. Podichetty VK, Spears J, Isaacs R , Booher J, Biscup RS. Complications Associated with Minimally Invasive Decompression for Lumbar Spinal Stenosis. Jour of Spinal Disor & Tech. May 2006;19(3):161-166

17. Spears J, Podichetty V, Isaacs RE, Biscup RS. Pedicle subtraction osteotomy with the use of an interbody device for the correction of sagittal imbalance. The Spine Journal, Vol 4, Issue 5, Suppl 10 Sep’ 2004, pp S79

18. Podichetty VK, Secic M, Whitfield M, Booher J, Biscup RS. Prescription Medication Use and Health Outcomes in Patients with Back Pain. Journal of Healthcare Quality. 2007 (In press)

ABSTRACTS 1. Spears J, Podichetty V, Isaacs RE, Biscup RS. Complications Associated with Open Versus Minimally

Invasive Spinal Decompression. 2004 AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting. San Diego, March 17-20, 2004

2. Podichetty V, Spears J, Isaacs RE, Biscup RS. Age-Based Comparative Outcomes of Elderly Patients Receiving Lumbar Decompression Surgery. 2004 AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting in San Diego, March 17-20, 2004

3. Isaacs RE, Podichetty V, Spears J, Nair S, Biscup RS. Complications Associated with Open Versus Minimally Invasive Spinal Decompression. 2004 AANS Annual Meeting Orlando, Florida. May 1- 6, 2004

4. Spears J, Podichetty V, Isaacs RE, Biscup RS. Pedicle subtraction osteotomy with the use of an Interbody device for the correction of sagittal imbalance. 2004 NASS 19th Annual Meeting. Chicago, IL. Oct’ 26 - 30, 2004

5. Podichetty V, Nematbakhsh A, Toumbis C, Isaacs RE, Biscup RS. A Novel Technique for Pedicle Subtraction Osteotomy using an Interbody Device. 2005 AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting. Phoenix, Arizona. March 9-12, 2005

6. Podichetty V, Nematbakhsh A, Toumbis C, Biscup RS, Isaacs RE. ASA Class, Not Age, Predicts Complications after Minimally Invasive Spine Surgery. 2005 AANS Annual Meeting. New Orleans, Louisiana, April 16 - 21, 2005

7. Podichetty VK, Booher J, Whitfield M, Biscup RS. Assessment of Internet use and effects among healthcare professionals. 2006 11th World Congress on Internet in Medicine (MEDNET' 06). Toronto, Canada, Oct 16-18,2006

8. Biscup RS, Isaza J, Anagnost S, Podichetty VK. Disc Stabilization Arthroplasty with a Spherical Metal Implant: Indications, Technique, and Analysis of 100 patients. 2007 Global Symposium on Motion Preservation Technology. Spine Arthroplasty Society, (SAS) 7th Annual Meeting. Berlin, Germany, May

8

1-4, 2007

9. Isaza J, Biscup RS, Anagnost S, Podichetty VK. Intradiscal Spherical Stabilization Device to Restore Normal Spinal Kinematics: Indications, Technique, and Early Results. 14th International Meeting on Advanced Spine Techniques (IMAST), Paradise Island, Bahamas, July 11-14, 2007.

BOOK CHAPTERS 1. Biscup R, Podichetty V. Satellite:Spherical Disc Replacement. In Yue J, Bertagnoli R, McAfee P, & An

H, ed. Motion Preservation Surgery of the Spine. Saunders, Philadelphia, 2008. pp 445-461

2. Podichetty V, Biscup RS. History of Spinal Fusion Surgery. Chapter 3. In (eds). Vaccaro AR, Papadopoulos S, Traynelis VC, Haid RW, Sasso RC: Spinal Arthroplasty: The Preservation of Motion. Philadelphia, Saunders Elsevier. 2007;21-35

3. Biscup RS, Podichetty V. Outpatient Microsurgical Lumbar discectomy and Microdecompression Laminoplasty. Chapter 39 H.M Mayer: Minimally Invasive Spine Surgery. 2nd edition New York: Springer-Verlag. 2006;356-363

4. R.S. Biscup, D.O., “Etiology, Evaluation, and Treatment of Patients Who Underwent Failed Lumbar Spine Surgery”. In Gunzburg, R., Szpalski, M. (eds). Lumbar Spinal Stenosis, Philadelphia, Lippincott-Williams & Wilkins, 2000

5. I.P. Enker, M.D., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., "Treatment of Multilevel Anterior and Retrolisthesis of the Lumbosacral Spine (Cascading Spine)." Lumbar Fusion and Stabilization,Tokyo, Springer Verlag, 1993.

PROFESSIONAL PRESENTATIONS 1. October, 1985, Honolulu, Hawaii. Annual Clinical Assembly of Osteopathic Specialists,:

"Segmental Spine Plate & Pedicle Screw Fixation for Spinal Disorders - A New Approach to Spinal Stabilization"

2. November, 1986, St. Louis, MO. Annual Clinical Assembly of Osteopathic Specialists: "Interbody

Fusion with Internal Fixation for Disorders of the Lumbosacral Spine" 3. November, 1988, San Antonio, Texas. Challenge of the Lumbar Spine: "Posterior Lumbar

Interbody Fusion & Internal Stabilization" 4. February, 1989, . Lutheran Medical Center, Cleveland, Ohio. First Annual International Spine

Seminar and Workshop: "Basic Pedicle Screw Technique"; "Interbody Fusion & Internal Stabilization"

5. August, 1989, Lutheran Medical Center, Cleveland, Ohio. Automated Percutaneous Discectomy:

Program Chairman & Presenter

9

6. February, 1990, Lutheran Medical Center, Cleveland, Ohio. Second Annual International Spine

Seminar and Workshop: "Basic Pedicle Screw Technique"; "Interbody Fusion & Internal Stabilization."; Program Director

7. October, 1990, Los Angeles, California. Annual Clinical Assembly of Osteopathic Specialists:

Program and Workshop Chairman; “Basic Pedicle Screw Technique and Interbody Fusion and Internal Stabilization”

8. August, 1990, Fifth Annual Meeting of the North American Spine Society: Scientific Exhibit: "An

Artificial Disc" A.D. Steffee, L. Keppler, M.D., R.S. Biscup, D.O. 9. August, 1990, Fifth Annual Meeting of the North American Spine Society: Scientific Exhibit:

"Vertebral Body Replacement for Tumor Resection" A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O.

10. August, 1990, Fifth Annual Meeting of the North American Spine Society: Scientific Exhibit:

"Closing Wedge Osteotomy for the Reduction of Thoracolumbar Kyphosis" A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O.

11. February, 1991, Lutheran Medical Center, Cleveland, Ohio. Third Annual International Spine

Seminar and Workshop: Program Director; "Basic Pedicle Screw Technique and Interbody Fusion and Internal Stabilization"

12. April, 1991, Vienna, Austria. Annual Austrian Orthopedic Society Meeting: "Reconstructive Spinal

Surgery of the Lumbar Spine using VSP and ISOLA Instrumentation"; Workshop Director, Lumbar Reconstructive Spinal Surgery

13. May, 1991, SRS/NASS Pedicle Fixation Course: Scientific Exhibit: "Treatment of Multilevel

Anterior and Retrolisthesis of the Lumbosacral Spine (Cascading Spine)" I.P. Enker, M.D., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., J.W. Brantigan, M.D.

14. August, 1991, Keystone, Colorado. Sixth Annual Meeting of the North American Spine Society:

"Treatment of Multilevel Anterior and Retrolisthesis of the Lumbosacral Spine (Cascading Spine)" I.P. Enker, M.D., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., J.W. Brantigan, M.D.

15. August, 1991, Keystone, Colorado. Sixth Annual Meeting of the North American Spine Society:

"Total Posterior Vertebrectomy and Vertebral Body Replacement” J.M. Cochran, D.O., L. Keppler, M.D., R.S. Biscup, D.O., J.W. Brantigan, M.D., I.P. Enker, M.D.

16. August, 1991, Keystone, Colorado. Sixth Annual Meeting of the North American Spine Society:

"Hypersensitivity Reactions to Stainless Steel Spinal Implants” B.T. Vest, M.D., L. Keppler, M.D., R.S. Biscup, D.O., J.W. Brantigan, M.D., I.P. Enker, M.D.

17. September, 1991, Montreal, Canada. Sixth International Symposium on Limb Salvage: Scientific

Exhibit, "Reconstruction of Post-Traumatic Bone Defects of the Upper and Lower Extremities" I.P. Enker, M.D., A.D. Steffee, M.D., L. Keppler, M.D., R.S. Biscup, D.O., J.W. Brantigan, M.D.

10

18. November, 1991, Paris, France. Annual Nexus Spine Symposium: Workshop Director on Lumbar Spinal Reconstructive Surgery

19. February, 1992, Lutheran Medical Center, Cleveland, Ohio. Fourth Annual International Spine

Seminar and Workshop: Program Director & Presenter 20. April, 1992, Athens, Ohio. Annual Continuing Medical Education Conference, Ohio University

College of Osteopathic Medicine: "Current Concepts Review - Biomechanical and Biochemical Aspects of Lumbar Spine Disorders"

21. April, 1992, Saalfelden, Austria. Annual Austrian Comesa Orthopedic Meeting: "Reconstructive

Spinal Surgery using Carbon Cage Prosthesis"; Workshop Director, Reconstructive Spinal Surgery with Carbon Cage Prosthesis

22. April, 1992, Bern, Switzerland. Department of Orthopedic Surgery, Inselspital Hospital, University

of Bern: "Treatment of Lumbar Spinal Disorders with VSP Spinal Instrumentation and Carbon Implants"

23. April, 1992, Marseille, France: "Indications, Technique, and Complications Associated with Lumbar

Spinal Reconstructive Surgery" 24. June, 1992, Cincinnati, Ohio. Ohio Osteopathic Association Annual Meeting: "Current

Approaches to Lumbar Spine Disorders - Diagnostic Imaging, and Surgical Treatment" 25. June, 1992, Lutheran Medical Center, Cleveland, Ohio. The Sports and Industrial Athlete, Part I.

Upper Extremities: Program Director; "Cervical and Thoracic Spine Injuries" 26. July, 1992, , Boston, Massachusetts. Seventh Annual Meeting of the North American Spine

Society: "Posterior Transvertebral Osteotomy for Adult Thoracolumbar Kyphosis" S.M. Lehmer, M.D., L. Keppler, M.D., R.S. Biscup, D.O., P. Enker, M.D., S.D. Miller, D.O., A.D. Steffee, M.D.

27. July, 1992, Boston, Massachusetts. Seventh Annual Meeting of the North American Spine

Society: "Artificial Disc Replacement: Preliminary Report with a Two-Year Minimum Follow-up. P. Enker, M.D., L. Keppler, M.D., R.S. Biscup, D.O., S.D. Miller, D.O., A.D. Steffee, M.D., C. McMillin, Ph.D.

28. July, 1992, Boston, Massachusetts. Seventh Annual Meeting of the North American Spine

Society: "Fibrin Adhesive as an Adjunct to Dural Repair” J. Cochran, D.O., D. Sitkowski, PA-C, L. Keppler, M.D., R.S. Biscup, D.O., P. Enker, M.D., S.D. Miller, D.O., A.D. Steffee, M.D.

29. July, 1992, Boston, Massachusetts. Seventh Annual Meeting of the North American Spine Society:

"Treatment of Spondyloptosis by Staged Resection and Fusion (Gaines Procedure)” S. Lehmer, M.D., L. Keppler, M.D., R.S. Biscup, D.O., P. Enker, M.D., S.D. Miller, D.O., A.D. Steffee, M.D., R.W. Gaines, Jr., M.D.

30. August, 1992, Lutheran Medical Center, Cleveland, Ohio. , Sports and Industrial Injuries, Part II:

"Advances in Operative Treatment of Lumbar Spine Injuries - The Uses and Abuses of Technology"

11

31. February, 1993, Annual Meeting of the American Academy of Orthopaedic Surgeons. Paper presentation: "Vertebral Body Replacement", P. Enker, M.D., L. Keppler, M.D., R.S. Biscup, D.O., J. Cochran, D.O., S.D. Miller, D.O., A.D. Steffee, M.D.

32. February, 1993, Annual Meeting of the American Academy of Orthopaedic Surgeons. Paper

presentation: "Artificial Disc Replacement: Preliminary Report with a Minimum Two-Year Follow-up", P. Enker, M.D., L. Keppler, M.D., R.S. Biscup, D.O., S.D. Miller, D.O., A.D. Steffee, M.D.

33. February, 1993, Lutheran Medical Center, Cleveland, Ohio. Fifth Annual International Advanced

Spine Seminar and Workshop: Program Director & Presenter 34. April, 1993, Saalfelden, Austria. Annual Austrian Comesa Orthopedic Meeting: "Preoperative

Assessment and Planning, Techniques, and Complications of Lumbar Spinal Reconstructive Surgery: Update with Clinical Case Presentations"

35. May, 1993, Kansas City, Missouri. Surgical Management of Spinal Deformity and Mechanical

Insufficiency: "Surgical Management of Degenerative Spinal Disorders" 36. May, 1993, Kansas City, Missouri. Surgical Management of Spinal Deformity and Mechanical

Insufficiency: "Spondylolisthesis: Preoperative planning, surgical techniques, and postoperative management"

37. May, 1993, Kansas City, Missouri. Surgical Management of Spinal Deformity and Mechanical

Insufficiency: "Surgical Management of Fractures, Tumors, and Infections of the Thoracolumbar Spine."

38. October, 1993, Chicago, Il. Annual Clinical Assembly of Osteopathic Specialists: "Spinal

Fractures: Classification, Surgical Treatment, and Outcome" 39. February, 1994, Vienna, Austria. International SICOT Trainees Meeting: "Segmental Spine

Reconstruction of the Lumbar Spine The Importance of Segmental Spinal Balance" 40. February, 1994, Lutheran Medical Center, Cleveland, Ohio. Sixth Annual International Advanced

Spine Seminar and Workshop: Program Director & Presenter 41. May, 1994, Cleveland, Ohio. 13th District Osteopathic Academy of Medicine Seminar: "New

Developments in the Surgical Management of Spinal Disorders." September, 1994, San Francisco, California. Third Annual Current Isuues of Magnetic Resonance

Imaging in Orthopedics and Sports Medicine: “Surgical Treatment of Lumbar and Cervical Spine Injuries”

42. September, 1994, Washington, D.C. Annual Clinical Assembly of Osteopathic Specialists:

"Application and Use of Carbon Fiber Implants in Orthopedic Surgery." 43. October, 1994, Athens, Greece. 20th Annual Symposium on Spinal Surgery of the Greek

Orthopedic Society: "Spinal Reconstructive Surgery of the Anterior Column Posterior and Anterior Approaches and Applications."

12

44. February, 1995, Lutheran Medical Center, Cleveland, Ohio. Seventh Annual Advanced International Spine Seminar and Workshop: Program Director & Presenter 45. April, 1995, Saalfelden, Austria - “Carbon Ramp Fixation in Lumbar Spinal Deformities - A new

Implant for use in Anterior Column Reconstruction” 46. October, 1995, Lutheran Medical Center, Cleveland, Ohio. Eight International Advanced Spine

Seminar and Workshop: Program Director & Presenter . 47. November, 1995, Lutheran Medical Center, Cleveland, Ohio. The Nurse in Spinal Surgery:

“Diagnostic Imaging for Spinal Disorders” 48. February, 1996, Lutheran Medical Center, Cleveland, Ohio. Ninth International Advanced Spine

Seminar and Workshop: Program Director & Presentor 49. May, 1996, La Jolla, California. The Nurse & Spinal Surgery: “Imaging for Lumbar Spinal

Disorders” 50. June, 1996, Galveston, Texas. 2nd Annual Current Concepts on Surgery of the Spine:

“Experience with Brantigan Carbon Cages for Interbody Fusion” 51. June, 1996, Galveston, Texas. 2nd Annual Current Concepts on Surgery of the Spine:

“Experience with VSP Spinal Instrumentation - Current Techniques & Pitfalls” 52. June, 1996, Galveston, Texas. 2nd Annual Current Concepts on Surgery of the Spine:

“Experience with ISOLA Spinal Instrumentation - Current Techniques & Pitfalls” 53. June, 1996, Galveston, Texas. 2nd Annual Current Concepts on Surgery of the Spine:

“Degenerative Spondylolisthesis & Cascading Spine: Etiology and Surgical Treatment” 54. October 1996, Vancouver, British Columbia, Canada. Annual Meeting of the North American

Spine Society: Scientific Exhibit: “Problems with the the Topping-Off Spinal Stabilization Procedure for Transition Zone Surgery”

55. October 1996, Vancouver, British Columbia, Canada. Annual Meeting of the North American

Spine Society: Scientific Exhibit: “Deep Spinal Would Infections Treated with Sugar Packing” 56. February 1997, Lutheran Medical Center, Cleveland, Ohio. Tenth International Advanced Spine

Seminar and Workshop: Program Director & Presentor 57. April 1997, Saalfelden, Austria. 10th COMESA Orthopedic Seminar and Workshop: “Spinal

Surgery in the Future” 58. May 1997, Baltimore, MD. 37th Annual Scientific Seminar, American Osteopathic Academy of

Orthopedics: “Minimally Invasive Spinal Surgery-Microscopic Approaches Using the Holmium Laser”.

59. May 1997, Baltimore, MD. 37th Annual Scientific Seminar, American Osteopathic Academy of

Orthopedics: “Laparoscopic Anterior Spinal Surgery and Fusion Techniques”

13

60. February 1998, Cleveland, OH. Eleventh International Advanced Spine Seminar and Workshop:

“Surgical Management of Low Grade Spondylolisthesis”, “Spinal Instrumentation in Osteoporosis Patients”.

61. May 1998, Cleveland Clinic, Cleveland, OH. First Endoscopic Spine Symposium and Workshop:

“Anterior Endoscopic Discectomy and Interbody Fusion with Manual Instruments and Square Cages/Bone Graft”, Workshop Faculty Member.

62. September 1998, Chicago, IL. Annual Clinical Assembly of Osteopathic Specialists: “Evaluation

and Management of Recurrent Disc Herniations in the Lumbar Spine.”

63. November 1998, Barcelona, Spain. 2nd International Meeting on Carbon Composite Spine Implants: “Carbon Composite Spine Implants used in Posterior Interbody Fusion Surgery: Technique, Complications and their Management.”

64. November 1998, Brussels, Belgium. Symposium on Spinal Stenosis: “Evaluation and Treatment

of Patients with Spine Surgery that has Failed – a New Multidisciplinary Appoach.” 65. January 1999, Whistler, BC. Annual Meeting, Ski With the Spine Center: “Case For - Spine

Fusion Cages.”, Workshop coordinator – PLIF Technique with Carbon Fiber I/F Cage Implants.” 66. February 1999, Cleveland, OH. 12th International Advanced Symposium on Spine Surgery and

Workshop: Program Co-Chairman, “Surgical Treatment of Spondylolisthesis using PLIF Techniques and Fusion Cage Implants.”

67. April 1999, Vienna, Austria. Symposium on Spine Surgery in the Elderly Patient: “Minimally

Invasive Spine Surgery in the Elderly Patient.” 68. April 1999, Groningen, Netherlands. Symposium – The Lumbar Spine in the Next Millenium:

“Evaluation and Treatment of Patients who have Failed Spine Surgery – A New Multidisciplinary Program at the Cleveland Clinic.”

69. May 1999, San Antonio, TX. Spine Workshop for Carbon Composite Interbody Fusion Cages:

“Indications, Complications and their Management in PLIF Surgery.” 70. June 1999, White Sulfer Springs, WV. 2nd Cleveland Clinic Orthopaedic Symposium:

“Rehabilitation for Spine Surgery Patients” 71. June 1999, White Sulfer Springs, WV. 2nd Cleveland Clinic Orthopaedic Symposium: “Degenerative Spondylolisthesis and Minimally Invasive Spine Surgery” 72. November, 1999, Cleveland, OH. Workshop on Posterior Lumbar Interbody Fusion Surgery:

Program Chairman, “Indications and Complications for PLIF Surgery with Cage Implants and Posterior Instrumentation”

73. May, 2000, Cleveland, OH. Cleveland Clinic 1st International Symposium on Spine Surgery that has Failed: Program Chairman

14

74. August, 2000, Cleveland, OH. Spine Review 2000: “PLIF sugery: Techniques & Complications”, “Lumbosacral fixation techniques”

75. Oct, 2000, Columbus, OH. Visiting Professor, OSU: “Spine Surgery that has Failed: Evaluation

and Treatment Options”, Director, PLIF cadaver workshop 76. March, 2001, Hong Kong, PRC. 7th International Conference on Intradiscal Surgery: “Revision

strategies for failed PLIF cages”, Director workshop, Panel member artificial disc strategies 77. March, 2001, Seoul, South Korea. Visiting Professor, University Severance Hospital, Wooridul

Spine Hospital 78. May, 2001, Key Largo, FL. Management of Spinal Pathologies: “Interbody fusion techniques with

pitfalls, complications, and their management”, “Spine surgery that has failed: evaluation and treatment options”

79. May, 2001, Cleveland, OH. Spine Review 2001: “Lumbar Spondylosis”, “PLIF surgery: approaches

& techniques”, workshop instructor, leader case presentations 80. August, 2001, Cleveland, OH. Spine Review 2001: “Lumbar Spondylosis” 81. August, 2001, Cleveland, OH. Spine Review 2001: “PLIF surgery with pedicle anatomy and sacral

fixation” 82. October, 2001, Sioux Falls, SD. Challenges in Spinal Surgery: “Revision of Interbody Fusion

Cages”, “Spine Surgery that has Failed: a Multidisciplinary Approach” 83. January, 2002, Vienna, Austria. Annual Austrian Spine Society: “Microdiscectomy and

Microdecompression Surgery” 84. January, 2002, Brussels, Belgium: University of Ghent Visiting Professor, surgery demonstration

and workshop, “PLIF and Posterior Instrumentation”, “Spine Surgery that has Failed-Evaluation and Treatment”

85. February, 2002, Key West, FL. CCF Pain Management Symposium: “Surgical options for chronic

back pain”, “Failed Spine Surgery: Evaluation and Treatment” 86. October, 2003, Weston, FL. Program Chairman, 1st Cleveland Clinic Florida Spine Review for

Primary Care Physicians: “Minimally Invasive Spine Surgery for Lumbar Spinal Stenosis”; “Surgical Treatment of Spondylolisthesis”; “Revision Spine Surgery – A Team Approach”

87. March, 2004, Naples, FL. CCF Current Climates in Medicine: “Innovations in Spinal Medicine and

Surgery.” 88. April, 2004, Cleveland, OH. AOAO Annual Postgraduate Seminar: “Disc Stabilization Arthroplasty

– Early Experience with a New Partial Disc Replacement Implant.” 89. May, 2004, Washington, DC. AOAO Annual Postgraduate Seminar: “A New Classification of

Degenerative Spondylolisthesis.”

15

90. February, 2005. Vienna, Austria. Annual Austrian Spine Society: “Disc Stabilization Arthroplasty

with Carbon Fiber Implants – Technique and Clinical Results”. 91. October, 2005, Weston, FL. Program Chairman, 2nd Cleveland Clinic Florida Spine Review or

Primary Care Physicians: “The Degenerative Spine Cascade”; “Minimally Invasive Surgery Options in Spinal Surgery”; Failed Spine Surgery – A Team Approach”.

92. May, 2006, Montreal, Canada. Spine Arthroplasty Society: “Disc Stabilization Arthroplasty using

Metal Sphere Implant – Historical Review, Technique, and Early Results”. 93. May, 2008, Boca Raton, FL. AOAO Annual Postgraduate Seminar: “Minimally Invasive Surgery

Options in the Aging Spine”. MEMBERSHIP IN GOOD STANDING IN PROFESSIONAL ORGANIZATIONS (Past & Present) Member, American Osteopathic Association Member, American Medical Association Member, Ohio Osteopathic Association Member, Ohio State Medical Association Member, Cleveland Academy of Osteopathic Medicine Member, Cleveland Academy of Medicine Member & Past President, Lorain Academy Osteopathic Medicine Member, American Osteopathic Academy of Orthopaedic Surgeons Member & Past-President, Section on Spinal Surgery,

American Osteopathic Academy of Orthopedic Surgeons

Member and Fellow, North American Spine Society Broward County Medical Association PROFESSIONAL/RESEARCH INTERESTS Minimally Invasive and Microscopic Spine Surgery Minimally Invasive Spine Surgery for Spinal Stenosis Microdiscectomy & Outpatient Spine Surgery Laser Spine Surgery (Open & Percutaneous)

Motion Preservation Surgery of the Spine

16

“Transition Zone” Surgery Functional Reconstruction of the Spinal Motion Segment Partial Disc Replacement

Major Reconstructive & Deformity Spine Surgery

Spinal Instrumentation (Posterior & Anterior) Anterior Column Reconstruction (PLIF & ALIF) Spinal Osteotomy Spinal Trauma and Tumor Surgery Carbon, Titanium, and Composite Spinal Implants Adult & Adolescent Scoliosis Surgery Cervical Spine Revision Spine Surgery INDUSTRY CONSULTING & INTELLECTUAL PROPERTY RELATIONSHIPS

June 1987 - 1997 AcroMed Corporation Cleveland, OH 44124 Consulting, Member of the Medical Advisory Panel Stock Options - Exercised Oct 1998 - Present DePuy Spine, a Subsidiary of Johnson & Johnson Rahynam, MA Consulting, Licensing of IP Royalties Sept 2002 - Present Medtronic Sofomor Danek 1800 Pyramid Place Memphis, TN 38132 800-876-3133 Consulting, Advisory Panel, Licensing of IP Royalties

REFERENCES Arthur D. Steffee, M.D. Emeritus Director, Cleveland Spine and Arthritis Center Riverstone Farm 595 Foxview Road Foxburg, PA 16036

17

Gordon Bell, M.D. Head Section on Spinal Surgery Department of Orthopaedic Surgery, A-41 Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, Ohio 44195 Edward C. Benzel, M.D. Director Spinal Disorders, S-80 Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195 David H. Krahe, D.O. Director, Residency Training Program Department of Orthopedic Surgery Meridia South Pointe Hospital 4110 Warrensville Center Road Cleveland, Ohio 44122 Behrooz A. Akbarnia, M.D. San Diego Spine Institute 8010 Frost, Suite 401 San Diego, California 92123 Marc A. Asher, M.D. The University of Kansas Medical Center, School of Medicine Orthopaedic Section 39th & Rainbow Boulevard Kansas City, Kansas 66103 Updated: January, 2009

Dr. Robert S. Biscup Chronology and Biography

High School *St. Joseph High School, Cleveland, OH

18

1970 *Varsity football *Senior Class president College *BA, 1974 *Hiram College, Hiram Ohio *Graduated cum laude, Departmental Honors in Chemistry *Organized Hiram College Premed/Paramedical Society *Organized and taught first multidisciplinary undergraduate college course on Modern Medicine in American Society Graduate School *MS, 1976 *Case Western Reserve University, Cleveland, OH *Health Sciences Education *Master’s Thesis on Continuing Medical Education, Program Design and Development Medical School *DO, 1980 *Ohio University College of Osteopathic Medicine *Member of the first charter class *Member of the Curriculum Committee *Class President *First OUCOM graduate to complete an orthopedic residency training program *Clinical Professor of Orthopedic Surgery *Commencement Address Medical School Graduation Ceremonies (2004) *Recipient of the first OUCOM Medal of Merit (2005), outstanding alumni award *Recipient of the Ohio University Medal of Merit (2007), outstanding alumni award Internship and Orthopedic Surgery Residency Training *1985 *Meridia South Pointe Hospital, Cleveland, OH *Akron Children’s Hospital, Akron, OH *University Hospitals of Cleveland *St Vincent Charity Hospital, Cleveland, OH *St. Luke’s Hospital of Cleveland, OH *Won the national resident competition research paper award, 1984 Dr. Arthur Steffee and AcroMed Corporation *1984-1997 *Cleveland, OH *Dr. Arthur D. Steffee Mentor for Training in Advanced Spinal Surgery *Dr. Steffee considered by many as the “father of modern spine surgery”

19

*Dr. Biscup consultant for AcroMed Corporation a new medical device company specializing in spine implants founded by Dr.Steffee *Dr. Biscup member of the prestigious AcroMed Medical Advisory Panel *Dr. Biscup helped developed world first spine pedicle screw and plate fixation system in the world *Dr. Steffee and Dr. Biscup publish the first professional paper on the use of segmental spine plates and pedicle fixation in the world (1986) *Dr. Biscup helped developed and test the world’s first spine fusion cage *With Dr. Steffee, Dr. Biscup performs world first artificial disc implant (1989) *Principle investigator for FDA study on spine fusion cages (1991-97) *Education Director for AcroMed Corporation *Chairman and Program Director for multiple national and international seminars and workshops on spine surgery in Cleveland, OH *International speaker, visiting professor, and guest surgeon (1988-1997) in multiple countries and renowned universities throughout Europe and Asia Cleveland Spine and Arthritis Center (CSAC) *1987-1997 *With Dr. Arthur Steffee, Dr. Louis Keppler, and Dr. John Collis, Dr. Biscup starts the renowned Cleveland Spine and Arthritis Center, the first specialty based clinic and hospital in the Midwest for spine and orthopedic surgery in Cleveland, OH. (1987) *This center became a destination medical facility attracting patients locally, nationally, and internationally *CSAC became a major training center for surgeons worldwide to study and learn about the new and cutting edge surgeries being developed and used at the CSAC *Dr. Biscup and Dr. Steffee perform the world’s first artificial disc implant surgery for the treatment of degenerative disc disease (1989) *Dr. Biscup became the Director of Medical Education and Director of the Spine Surgery Fellowship Training Program at the CSAC (1989) *Dr. Biscup becomes one of the Team Physicians for the Cleveland Indians Professional Baseball Team (1991) *Dr. Biscup pioneers the use of the Holmium Yag Laser for applications in spinal surgery working with Coherent Laser Company and performs the world’s first laser assisted spine operation in the world (1989) *Dr. Biscup organizes and teaches workshops through Coherent Laser Company at national meetings on the use of the Holmium Laser (1989-1991) *Dr. Biscup performs the world’s first operation(s) using specially designed carbon fiber implants in spinal reconstruction surgery that he developed in conjunction with AcroMed Corporation. Many of these surgeries were performed using minimally invasive and laproscopic techniques not done before (1993, 1995, and 1997) *Dr.Biscup becomes a Fellow of the North American Spine Society (1988) *Dr. Biscup in association with several prominent and nationally recognized spine surgeons, begins developing minimally invasive spinal decompression surgery techniques for the symptomatic treatment of spinal stenosis (1989) *Dr. Steffee retires from the CSAC (1997) Cleveland Clinic Foundation (CCF) *1997-2002 *Dr. Biscup invited to join the medical staff of the Cleveland Clinic Foundation, Cleveland, OH (1997) *Dr. Biscup named the Director of the CCF Regional Spine Program (1998) *Dr. Biscup named the Director of the CCF National Center for Revision Spine Surgery (1999)

20

*Dr. Biscup and his Staff receive the Patient Advocate Award from the American Academy of Pain Management for his innovative and successful approach to the evaluation and treatment of patients suffering from spine surgery that has failed (2002) *Dr. Biscup receives the annual Outstanding Educator Award of the Department of Orthopaedic Surgery chosen by the residents as the best educator out of 43 faculty staff members (2002) *Dr. Biscup develops one of the largest spine surgery practices at the Cleveland Clinic and treats patients from all of the world including members of a royal family from the Middle East *At the request of the government of Abu Dubai, Dr. Biscup leads a team of Cleveland Clinic Spine Physicians to evaluate patients and successfully performs surgery in their country (2001) *Dr. Biscup invited by the CCF CEO and Board of Governors to come to SE Florida, develop and become the Chairman and Director of the Cleveland Clinic Florida Spine Institute in both Naples and Fort Lauderdale (2002) *CCF consistently recognized as one of the top three hospitals in the United States by US News and World Report *CCF Orthopaedic Department recognized as one of the top five departments in the United States by US News and World Report Cleveland Clinic Florida (CCFL) *2003-2007 *Dr. Biscup becomes the Chairman and Director of the Cleveland Clinic Florida Spine Institute at Cleveland Clinic Foundation facilities in both Naples and Fort Lauderdale/Weston facilities (2003) *Dr. Biscup designs the CCFL Spine Institute facility and raises $8M through philanthropy and grateful patients to build the state of the art integrative spinal medicine center (2004) *Dr. Biscup awarded the Growth Award at the CCFL (2003, 2004) *CCFL Spine Institute becomes a nationally and internally recognized spine center with 35% of patients coming from outside of the SE Florida area *Dr. Biscup becomes the Director of the CCFL Spine Fellowship Program and trains young surgeons in advanced spine surgery (2003) *Dr. Biscup brings a variety of new and innovative spine surgery procedures to the SE Florida area not previously being performed Biscup Spine *2007-Present *Dr. Biscup resigns from the Cleveland Clinic Florida and begins private practice at the Biscup Spine (2007) *Biscup Spine incorporates the concierge model for health care *Dr. Biscup incorporates health maintenance and functional wellness into his recommendations American Osteopathic Academy of Orthopedics (AOAO) *Dr. Biscup becomes an active member of the AOAO (1985) *Dr. Biscup becomes Board Certified in Orthopedic Surgery (1988) *Dr. Biscup founder and first president of the Section on Spinal Surgery of the AOAO (1991-93) *Dr. Biscup elected Fellow of the AOAO (1993) *Dr. Biscup becomes a senior examiner for the American Osteopathic Board of Orthopedic Surgery (1995-present)

21

*Dr. Biscup remains active in his Professional Academy giving lectures at national meetings, teaching young doctors and surgeons, and serving on various committees as requested including the American Osteopathic Board of Orthopedic Surgery Industry Consulting and Cutting Edge Technology *1987-present *Dr. Biscup becomes a consultant and member of the Medical Advisory Panel of AcroMed Corporation, Cleveland, OH (1987) *Dr. Biscup becomes a consultant and licenses patents to DePuy/Johnson and Johnson for special spine fusion cages (2003) *Dr. Biscup becomes a consultant and licenses patents to Medtronic Sofomor Danek for disc replacement device (2003) *Dr. Biscup designs and develops a new spine fixation system representing the next generation of spine stabilization implants. *Dr. Biscup continues to be an active and sought after consultant in the medical device industry for new and innovative approaches to implant design, miniamlly invasive surgical technique, research, and education and training (present)