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CURRICULUM VITAE
Name: François Proulx Date of birth: August 22nd, 1963 Citizenship: Canadian Spoken languages: French and English Written languages: French and English Hospital Address: CHU Sainte-Justine Department of Pediatric Critical Care, 3rd floor block 4 3175 Chemin Côte-Ste-Catherine Montreal (Québec) Canada H3T 1C5 Tel office: (514) 345-4931 *5562 or *5549 Fax office: (514) 345-7731 e-mail: [email protected]
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Education 1982-1987 Undergraduate medical studies 1987-1991 Residency in Pediatrics: Sainte-Justine Hospital University of Montreal 1990 Pediatric Advance Life Support 1990-1992 Fellowship in Pediatric Intensive Care, Sainte-Justine Hospital, Montreal Program certified by the Royal College of Canada 1992-1993 Fellowship in Pediatric Intensive Care Texas Children's Hospital; Baylor College of Medicine, Houston, Texas 1991 Statistics no. 6033 Independant student, University of Montreal, Department of Pharmacology 1992 Epidemiology no. 193 University of Montreal Department of Public Health 1992 Statistics and Epidemiology Baylor College of Medicine, Houston, Texas Diplomas 1985 Doctor of Medicine (MD) University of Montreal 1985 Licenciate, Medical Council of Canada (LMCC) 1991 Specialist Certificate in Pediatrics Corporation Professionnelle des Médecins du Québec 1991 Specialist Certificate in Pediatrics Royal College of Physicians and Surgeons of Canada (FRCPC) 1992 Certificate in Pediatric Critical Care University of Montreal
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1993 Clinical instructor Faculty of Medicine University of Montreal 1995 Clinical assistant professor Faculty of Medicine University of Montreal 1997 Affectation to the "Fédération des Études Supérieures" (M. Sc., diplomas or certificates 2nd cycle) 2002 Clinical associate professor
Faculty of Medicine University of Montreal
Medical fields Pediatric Intensive Care, Hemolytic uremic syndrome, E. coli O157:H7; Inflammation, Cytokines, Chemokines, Sepsis, Multiple organ dysfunction syndrome, transpulmonary thermodilution. Offices
• Active Member of the Ste-Justine Hospital Research Centre, 1994-2015. • Members of various hospital committee: between 1994-2015 (trauma, CPR, nosocomial
infections, vascular access) • Member of the University of Montreal pedagogic committee on pediatric intensive care,
1996-2015. • President of the sub-committee on the evaluation of the quality of medical act in the
pediatric intensive care unit, 1997-2015.
Experience
● Medical staff, Centre Hospitalier Honoré-Mercier, 1991-1993.
● Emergency staff, Ste-Justine Hospital, 1994-1999.
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Abstracts: 1. Proulx F, Turgeon JP, Delage G, Lafleur L and Chicoine L. Clinical trial of trimethoprim-
sulfamethoxazole in Escherichia coli O157:H7 hemorrhagic colitis. .Clin Invest Med 1991;14:A77.
2. Proulx F, Turgeon JP, Delage G, Lior H, Lafleur L. Antibodies to verotoxin (VT)-1 and
VT-2 in hemolytic uremic syndrome and hemorrhagic colitis. Pediatr Res 1992;31:A176. 3. Turgeon JP, Proulx F, Delage G, Lior H, Lafleur L, Chicoine L. Immune response to
verotoxin (VT)-1 and VT-2 in children with hemorrhagic colitis and hemolytic uremic syndrome. Clin Invest Med 1992;15:A111.
4. Proulx F, Gauthier M, Nadeau D, Lacroix J, Farrell CA. Timing and predictors of death in
pediatric multiple organ system failure. Clin Invest Med 1992;15:A127. 5. Proulx F, Lambert M, Lacroix J, Nadeau D, Gauthier M, Qureshi IA. Acquired carnitine
insufficiency in children admitted to the pediatric intensive care unit. Clin Invest Med 1992;15:A127.
6. de Jaeger A, Proulx F, Fayon M, Lacroix J, Farrell CA, Gauthier M. Pronostic markers in
children with multiple organ dysfunction syndrome. Clin Invest Med 1995;18:A36. (Suppl.)
7. Proulx F, Fayon M, Lacroix J, Farrell CA, Gauthier M. Childhood multiple organ
dysfunction syndrome. 24 congress Société de Réanimation de Langue Française. Paris 1996; Réanimation Urgences 1996;4:714.
8. Vobecky S, Ruest P, Proulx F, Chartrand C. Inhaled nitric oxide in postoperative
management of complete atroiventricular septal defect. Can J Cardiol 1996;12:145E. 9. de Jaeger A. Proulx F, Yandza T, Boeuf B, Manika A, Lacroix J, Lambert M. Marqueurs
de la dysoxie cellulaire dans un modèle de transplantation hépatique chez le cochon. Réanimation Urgences 1996;5:SEO 24.
10. Gauvin F, Lebel P, Moghrabi A, Farrell CA, Proulx F. Reproductibilité de l'analyse des
sécrétions respiratoires obtenues par un lavage bronchoalvéolaire protégé fait à l'aveugle. Réanimation Urgences 1996;5:079.
11. Farrell CA, Tucci M. Toledano B, Lacroix J, Proulx F. Facteurs favorisant le don
d'organes en réanimation pédiatique. Réanimation Urgences 1996;5:O30. 12. Proulx F, Litalien C, Turgeon JP, Mariscalco MM, Seidman E. Inflammatory mediators in
hemorrhagic colitis and hemolytic uremic syndrome. Crit Care Med 1997;25:A68. 13. Yandza T, Busque S, de Jaeger A, Manika A, Proulx F. Effect of cold-storage and
reperfusion on hepatic cellular glutathione. Abstract book of the 2nd European congress of Pediatric Surgery 1997:65.
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14. Rowe PC, Milner R, Orrbine E, Klassen T, Goodyer PG, Mackenzie AM, Wells GA,
Auclair F, Blanchard C, Lior H, Rafter DI, McLaine PN, Armstrong GD, and the CPKDRC Synsorb-Pk Study Group. A phase II randomized controlled trial of Synsorb Pk for the prevention of hemolytic uremic syndrome in children with verotoxin producing E. coli (VTEC) gastroenteritis. Pediatr Res 1997; 41:283A.
15. Rowe PC, Orrbine E, Wells GA, Lior H, McLaine PN and the CPKDRC co-invetigators.
Risk of hemolytic uremic syndrome following sporadic E. coli O157 infection: Result of a Canadian collaborative study. Third International VTEC Conference 1997, Baltimore.
16. Lebel P, Mackenzie AM, Orrbine E, Hyde L, Rowe PC, McLaine PN, and CPKDRC
Synsorb-Pk co-investigators. Sensitivity and specificity of Meridian Premier EHEC and rapid 0157 enzyme immunoassay tests for the diagnosis of enterohaemorrhagic Escherichia coli. 97th American Society for Microbiology 1997.
17. Mackenzie AM, Lebel P, Orrbine E, Hydel, Rowe PC, Chan F, McLaine PN and the
CPKDRC Co investigagors. Sensitivity and specificity of Meridian immunoassay tests for enterohaemorrhagic Escherichia coli Third International VTEC Conference 1997, Baltimore. V118/VI
18. de Jaeger A, Proulx F, Yandza T, Boeuf B, Manika A, Lacroix J, Lambert M. Markers of
cellular dysoxia during orthotopic liver transplantation and early reperfusion in pigs. 7th World congress of Intensive and Critical Care Medicine. 1997:189. 19. Chaibou M, Tucci M, Dugas MA, Lacroix J, Farrell CA, Proulx F. Clinically significant
upper gastrointestinal bleeding acquired in a pediatric intensive care unit: A prospective study. Intensive Care Medicine 1997;23:S140.
20. Yandza T, manika T, Huynh G, Lagacé, Dugas M, Proulx F. Limites de la transplantation
du foie a partir du donneur en arret cardiaque prolongé. 54e congrès de la Société Française de chirurgie pédiatrique. Paris, September 11, 1997.
21. Gauvin F, Chaibou M, Proulx F, Hume H, Lacroix J. Pratique de transfusion érythrocytaire
en réanimation pédiatrique. Réanimation Urg. 1997;6:749.SPO 40. 22. Proulx F, Dugas MA, Litalien C, Seidman E. La réponse lymphocytaire T helper-1 et T
helper-2 durant la colite hémorragique et le syndrome hémolytique urémique.. Réanimation Urgences. 1997;6:784.SPA 78.
23. Boeuf B, Proulx F, Morneau S, Marton D, Lacroix J. Innocuité de la Rh DNAse
(Pulmozyme®) dans le traitement des atélectasies pulmonaires chez l'enfant ventilé mécaniquement. Réanimation Urg. 1997;6:802. SPA153.
24. Dugas MA, Proulx F, de Jaeger A, Lambert M, Lacroix J. Marqueurs de dysoxie cellulaire
durant le choc septique chez l'enfant. Réanimation Urg. 1997;6:760. SPO 84
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25. Leteurtre S, Martinot A, Duhamel A, Gauvin F, Grandbastien B, Nam TV, Proulx F, Cloup M, Lacroix J, et Leclerc F. Développement d'un score de dysfonction d'organes chez l'enfant. Réanimation Urg. 1997;6:741:SPO8.
26. Litalien C, Proulx F, Mariscalco MM, Robitaille P, Turgeon JP, Orrbine E, Rowe PC,
McLaine PN and Seidman E. Circulating inflammatory cytokine levels predict severity of renal failure in hemolytic uremic syndrome. Crit Care Med 1999;S27:A132.
27. Proulx F, Tucci M, Toledano B, Mariscalco MM, Lee KB, Seidman E, Caroll SF.
Circulating levels of lipopolysaccharide binding protein in children with Escherichia coli O157:H7 hemorrhagic colitis and hemolytic uremic syndrome. Abstract book of the 6th International Congress of the European Society of Pediatric and Neonatal Intensive Care. 1999.
28. Sznajer Y, Tucci M, Proulx F, Farrell CA, Lacroix J, Gauvin F, Toledano BJ. Altered
spontaneous and platelet-activating factor mediated neutrophil apoptosis in neonates compared to adults. Am Respiratory J Crit Care Med 2000:A78
29. Masri C, Proulx F, Toledano B, Clermont MJ, Liet JM, Mariscalco MM, Seidman E,
Carcillo J. Concentrations circulantes de l'antigène Fas soluble et de son ligand durant les infections à Escherichia coli O157:H7. Réanimation Urg 2000;8: (suppl 3):211 SP272.
30. Masri C, Proulx F, Vobecky SJ, Tucci M, Toledano BJ. Neutrophil apoptosis is decreased
post cardiopulmonary bypass. Pediatr Crit Care Med 2000;1:67.(suppl) 31. Masri C, Proulx F, Toledano B, Mariscalco MM, Carcillo J. Solube Fas and soluble Fas-
Ligand in children with Escherichia coli O157:H7 infections. Pediatr Crit Care Med 2000;1:107. (suppl)
32. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, Gottesman R,
Joffe A, Pfenniger J, Hubert P, Lacroix J, Leclerc F. L'adaptation du score pediatric risk of mortality (PRISM) à la population étudiée est-elle nécessaire? Réanimation Urgences 2001;10 (suppl 1); SP288.
33. Desmet LE, Gendron R, Proulx F, Vobecky SJ and Toledano BJ. Pediatric patients who
develop complications post cardiopulmonary bypass have altered neutrophil apoptosis and necrosis. Toronto Critical Care Medicine Symposium 2002.
34. Ennaciri J, Menezes J, Proulx F, Toledano BJ. Induction of Apoptosis by herpes simplex
virus in neonatal, but not adult neutrophils Pediatr Crit Care Med 2002; 4;3:A149. 35. Proulx F, Wagner E, Toledano B, Decaluwe H, Rivard GE. Mannan-binding lectin in
children with E. coli O157:H7 hemorrhagic colitis and hemolytic uremic syndrome. Toronto Critical Care Medicine Symposium 2002.
36. Gauvin F, Dassa C, Chaïbou M, Proulx F, Farrell CA, Lacroix J. Ventilator-associated
pneumonia in intubated children: comparison of different diagnostic methods. Crit Care 2003; 7 (Suppl 2):P145
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37. Sockett P, Proulx F. National study of Paediatric Haemolytic Uraemic syndrome in
Canada. 5th nternational symposium and workshop on Shiga toxin (verocytotoxin) producing E. coli infections, Edinburgh, June 8-11 2003. www.VTEC2003.com
38. Verrijckt A, Proulx F, Morneau S, Vobecky S, Rivard GE. Activated recombinant factor
VII for refractory bleeding during extracorporeal membrane oxygenation. Toronto Critical Care Medicine Symposium October 31st, 2003.
39. Leteurtre S, Grandbastien B, Duhamel A, Gauvin F, Proulx F, Nam Vu T, Martinot A,
Lacroix J, Leclerc F. Étude de l’influence assoicée du syndrome de défaillance multiviscérale, du SRIS, sepsis, sepsis sévère et choc septique sur la mortalité en réanimation pédiatrique. Société de Réanimation de Langue Française. Paris, Jan 2003.
40. Elliott E, Lynn R, Schmid H, Proulx F, Wong W, Sockett P, Coelho M, Adek R, on behalf
of members of the Australian, British, Canadian, New Zealand, Swiss and Portuguese Paediatric Surveillance Units/HUS study groups. Surveillance of Haemolytic Uraemic Syndrome: An international collaboration. 3rd meeting of the INOPSU Pediatric Surveillance. Lisbon, Portugal, April 22, 2004.
41. Decaluwe H, Proulx F, Mariscalco MM, Gendrel D, Bohuon C. Procalcitonin in children
with Escherichia Coli O157:H7 hemorrhagic colitis and hemolytic uremic syndrome. 12th International Congress of Immunology and 4th Annual Conference of FOCIS. J Exp Med 2004; 27(4):175B.
42. Verrijckt A, Proulx F, Morneau S, Vobecky S, Rivard GE. Activated recombinant factor VII
for refractory bleeding during extracorporeal membrane oxygenation. Miami, USA March 10, 2004.
43. Ramos MV, Fernandez G, Betancor L, Camerano G, Gran G, Exeni R, Alduncin M, Isturiz
M, Proulx F, Palermo M. In vitro and In vivo effects of Shiga toxin on circulating human monocytes. Analysis of fractalkine receptor. Annual Meeting of Biomedical Societies, November 16-20, Mar del Plata, Argentine. Medicina 64 (supl II), 174, 2004.
44. Proulx F, Christen E, Patrick J, Combadière C, Tratchman H. Urinary fractalkine excretion
in pediatric patients with diarrhea associated hemolytic uremic syndrome. May 15, No 1070 Pediatr Res 2005.
45. Leteurtre S, Martinot A, Duhamel A, Proulx F , Grandbastien B, Cotting J, Gottesman R,
Joffe A, Pfenninger J, Hubert P, Lacroix J, Leclerc F. Cinétique des dysfonctions d’organe mesurées pas le score PELOD chez l’enfant : Étude prospective multicentrique internationale. Société de Réanimation de Langue Française. Paris, Jan 2005.
46. Ramos MV; Fernandez GC; Schierloh P; Elias-Costa C; Vallejo G; Exeni R; Alduncin M; Proulx F; Sasiain MC; Palermo M. Expression of fractalkine receptor (CX3CR1) in
monocytes and natural killer cells from hemolytic uremic syndrome patients. Latino american Congress of Immunology, Córdoba, Argentina, October 2005.
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47. Leteurtre S, Grandbastien B, Duhamel A, Gauvin F, Proulx F, Nam Vu T, Martinot A, Farges C, Hatzakis G, Lesage F, Dupic L, Hubert P, Brochard L, Jouvet P. Computer-driven mechanical ventilation: A Phase II clinical trial in children. ATS, San Diego 2005.
48. Proulx F, Palermo M, Fernandez G, Trachtman H, Combadière C. Circulating levels of
soluble fractalkine (CX3CL1) in children with diarrhea associated haemolytic uremic syndrome. 2005. Toronto Crit Care Medicine Symposium p.112.
49. St-Louis P, Simon L, Gauvin F, Proulx F, Amre D, Lacroix J. The comparative utility of procalcitonin and C-reactive protein as markers of sepsis in a pediatric ICU population with SIRS. 2005 AACC Annual Meeting, Orlando, Florida.
50. Ramos MV, Fernandez G, Schierloh P, Elias Costa C, Vallejo G, Exeni R, Alduncin M ; Proulx F, Sasiain M, Palermo M. Expression of fractalkine receptor (CX3CR1) in monocytes and natural killer cells from hemolytic uremic syndrome Ppatients. 2006 6th International Symposium on Shiga toxin (Verocytotoxin) producing E. coli infections (VTEC 2006). Melbourn, Australia, November 2006.
51. Leteurtre S, Duhamel A, Grandbastien B, Lacroix J, Proulx F, Cotting J, Gottesman R,
Joffe A, Pfenninger J, Hubert P, Martinot A, Leclerc F. Determination of the best days for the measurement of sequential PELOD score during the PICU stay. Pediatr Crit Care Med 2007; 8 (3):FP23.3.1010.
52. Villeneuve A, Lacroix J, Proulx F, Ducruet T. Multiple organ dysfunction syndrome
(MODS) in critically ill children : Value of two sets of diagnostic criteria. Crit Care Med 2011;39:12 (suppl), A114, no 416.
Scientific Publications (in peer reviewed Journal) 1. Proulx F, Turgeon JP, Delage G, Lafleur L, Chicoine L. Randomized controlled trial of
antibiotic therapy for Escherichia coli O157:H7 enteritis. J Pediatr 1992;121:299-303. 2. Proulx F, Weber ML, Collu R, Lelièvre M, Larbrisseau A, Delisle M. Hypothalamic
dysfunction in a child: A distinct syndrome? Report of a case and review of the literature. Eur J Pediatr 1993;152:526-9.
3. Proulx F, Lacroix J, Farrell CA, Gauthier M. Convulsions and hypertension in children:
Cause or effect? Crit Care Med 1993;21:1541-6. 4. Proulx F, Gauthier M, Nadeau D, Lacroix J, Farrell CA. Timing and predictors of death in
pediatric multiple organ system failure. Crit Care Med 1994;22:1025-31.
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5. Proulx F, Turgeon JP, Delage G, Lior H, Lafleur L, Chicoine L . Immune response to verotoxin (VT)-1 and VT-2 in children with hemorrhagic colitis and hemolytic uremic syndrome. Can J Infect Dis 1995;6:136-40.
6. Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and
multiple organ dysfunction syndrome. Chest 1996;109:1033-7. 7. Proulx F, Lacroix J, Farrell CA, Lambert M. Blood lactate and gastric intramucosal pH
during severe sepsis. Crit Care Med 1996;24:1092. 8. Proulx F, Lacroix J, Qureshi IA, Gauthier M, Nadeau D, Lambert M. Acquired carnitine
insufficiency in children admitted to the pediatric intensive care unit. Eur J Pediatr 1997;156:864-9.
9. Proulx F, Morneau S, Boeuf B, Vobecky S, Ruest P. Simultaneous administration of nitric
oxide in two children with pulmonary hypertension. Chest 1997;112:569. 10. Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and
multiple organ dysfunction syndrome. In: Parillo JE, Balk RA, Calvin JE, Franklin CM, Shapiro BA (Eds). Year Book of Critical Care Medicine St-Louis: Mosby 1997:3-29.
11. Yandza T, Manika A, Huynh T, Lavoie JC, Champagne J, Lepage G, Chessex Ph, Busque
S, Proulx F. Glutathion intra-hépatique et stress oxydatif en transplantation du foie chez le cochon. Ann Chir 1997;8:839-44.
12. de Jaeger A, Proulx F, Yandza T, Dugas MA, Boeuf B, Manika A, Lacroix J, Lambert M.
Markers of cellular dysoxia during orthotopic liver transplantation in pigs. Intensive Care Med 1998;24:268-75
13. Proulx F, Litalien C, Turgeon JP, Mariscalco MM, Seidman E. Inflammatory mediators in
hemorrhagic colitis and hemolytic uremic syndrome. Pediatr Inf Dis J 1998;17:899-904. 14. Boeuf B, Proulx F, Morneau S, Marton D, Lacroix J. Safety of Endotracheal Rh DNAse
(Pulmozyme®) for Treatment of Pulmonary Atelectasis in Mechanically Ventilated Children. Pediatr Pulmonol 1998;26:147.
15. Chaibou M, Tucci M, Dugas MA, Farrell CA, Proulx F, Lacroix J. Clinically significant
upper gastrointestnal bleeding acquired in a pediatric intensive care unit: A prospective study. Pediatrics 1998;102:933-938.
16. MacKenzie AMR, Lebel P, Orrbine E, Rowe PC, Hyde L, Chan FC, Johnson W, McLaine
PN and the members of the CPKDRC. Senitivities and specificities of Premier E. coli O157 and Premier EHEC enzyme immunoassays tests for diagnosis of infection with Shigella like toxin (verotoxin)-producing Escherichia coli. J Clin Microbiol 1998;36:1608-1611.
17. Guerguerian AM, Toledano B, Tucci M, Farrell CA, Proulx F, Lacroix J. Encéphalite
aigue grave pédiatique: 14 cas consécutifs. Réanim Urgences 1999;8:395-8.
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18. Litalien C, Proulx F, Mariscalco MM, Robitaille P, Turgeon JP, Orrbine E, Rowe PC,
McLaine PN and Seidman E. Circulating inflammatory cytokine levels predict severity of renal failure in hemolytic uremic syndrome. Pediatr Nephrol 1999;13:840-845.
19. Manika A, Trinh T, Lagacé G, Dugas MA, Proulx F, Lepage G, Champagne J, Lavoie JC,
Cousineau J, Russo P, Chartrand C, Yandza T. N-acetylcysteine in pig liver transplantation from non-heart-beating donnors. Transplantation 1999;68:327-30.
20. Proulx F, Seidman E. Is it time for a randomized trial of antibiotic therapy in Escherichia
coli O157:H7 enteritis? Eur J Clin Microbiol Infect Dis 1999:18: 533 (Editorial) 21. Proulx F, Mariscalco MM, Seidman E, Lee K; and Caroll SF. Increased circulating levels
of lipopolysaccharide binding protein in children with Escherichia coli O157:H7 hemorrhagic colitis and hemolytic uremic syndrome. Clinical and Diagnostic Laboratory Immunology. 1999; 6:773.
22. Dugas MA, Proulx F, de Jaeger A, Lacroix J and Lambert M. Markers of cellular dysoxia
in children with sepsis. Intensive Care Med 2000;26:75-83. 23. Proulx F, Litalien C, Turgeon JP, Mariscalco MM, Seidman E. Circulating levels of
transforming growth factor beta 1 and lymphokines in children with hemolytic uremic syndrome. Am J Kid Dis 2000;35:1-7.
24. Proulx F, Liet JM, David M, Seidman E, Tapiero B, Robitaille P, Lacroix J. Hemolytic
uremic syndrome associated with invasive Streptococcus pneumoniae infection. Pediatrics 2000;105:462-463.
25. Leteurtre S, Martinot A, Duhamel A, Gauvin F, Grandbastien B, Nam TV, Proulx F,
Lacroix J, Leclerc F. Development of a Pediatric multiple organ dysfunction score: Use of two strategies. Medical Decision Making 1999;19:399-410.
26. Buteau C, Proulx F, Chaibou M, Raymond D, Clermont MJ, Mariscalco M, Lebel MH,
and Seidman E. Leukocytosis in children with Escherichia coli O157:H7 enteritis developing the hemolytic uremic syndrome. Pediatr Infect Dis J 2000;19:642-647.
27. Masri C, Proulx F, Toledano B, Clermont MJ, Liet JM, Mariscalco MM, Seidman E,
Carcillo J. Soluble Fas and soluble Fas-Ligand in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Am J Kid Dis 2000;36:687-694.
28. Mitchell G, Cossette P, Lortie A, Decarie JC, Proulx F, Qureshi IA, Lambert M. Central
pontine and extrapontine myelinolysis, a reversible cause of coma in partial OTC deficiency. J Inherit Metab Dis 2000, 23 (suppl.1):54.
29. Gauvin F, Chaibou M, Leteurtre S, Toledano B, Hume H, Proulx F, Hebert PC, Martinot
A, Leclerc F, Lacroix J. Transfusion de concentre globulaire en reanimation pediatrique. Reanim Urgences 2000;9:339-344.
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30. Proulx F, Seidman E, Karpman D. The pathogenesis of Shiga toxin producing Escherichia coli associated hemolytic uremic syndrome. Pediatr Res 2001;50:1-9.
31. Gauvin F, Lacroix J, Guertin MC, Proulx F, Farrell CA, Moghrabi A, Lebel P, Dassa C.
Reproducibility of blind protected bronchoalveolar lavage in mechanically-ventilated children. Am J Respir Crit Care Med 2002;165:1618-23.
32. Proulx F, Toledano B, Phan V, Clermont MJ, Mariscalco MM and Seidman EG.
Circulating G-CSF, C-X-C and C-C chemokines in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatr Res 2002;52:1-7.
33. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, Gottesman R,
Joffe A, Pfenninger J, Hubert P, Lacroix J, Leclerc F. Validation of the paediatric logistic organ dysfunction (PELOD) score. Prospective, observational, multicenter study. Lancet 2003; 362:192-97.
34. Proulx F, Wagner E, Toledano B, Decaluwe H, Seidman E, Rivard GE. Mannan-binding
lectin in children with E. coli O157:H7 associated hemolytic uremic syndrome. Clin Exp Immunol 2003;133:360-3.
35. Gauvin F, Dassa C, Chaibou M, Proulx F, Farrell CA, Lacroix J. Ventilator-associated
pneumoniae in intubated children : Comparison of different diagnostic methods. Pediatr Crit Care Med 2003; 4:437-443.
36. Verrijckt A, Proulx F, Morneau S, Vobecky S, Rivard GE. Activated recombinant factor
VII for refractory bleeding during extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg 2004; 127:1812-13.
37. Proulx F, Sockett P. Prospective surveillance of Canadian children with hemolytic uremic
syndrome. Pediatr Nephrol 2005;20:786-790. 38. Leclerc F, Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Martinot A, Gauvin F, Nam
TV, Hubert P, Lacroix J. Cumulative influence of organ dysfunction and septic state on mortality of critically ill children. Am J Respir Crit Care Med 2005; 171:348-353.
39. Ennaciri J, Menezes J, Proulx F, Toledano BJ. Induction of apoptosis by herpes simplex
virus 1 in neonatal but not adult neutrophils. 2005 Pediatr Res 59:7-12. 40. Decaluwe H, Harrison L, Mariscalco MM, Gendrel D, Bohuon C, Tesh VL, Proulx F.
Procalcitonin in children with Escherichia Coli O157:H7 hemorrhagic colitis and hemolytic uremic syndrome. Pediatr Res 2006; 59 (4): 1-5.
41. Ramos MV, Fernández GC,, Scherlock P, Exeni R, Grimoldi I, Vallejo G, Elías-Costa C,
Sasiain MC, Proulx F, Palermo MS. Involvement of fractalkine pathway in the pathogenesis of haemolytic uraemic syndrome. Blood 2007; 109 (6): 2438-2445.
42. Proulx F, Joyal JS, Leteurtre S, Mariscalco MM, Leclerc F, Lacroix J. The pediatric multiple
organ dysfunction syndrome. Pediatr Crit Care Med 2009;10(1):1-11.
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43. Khan F, Proulx F, Lingwood C. Detergent resistant globotriaosyl ceramide may define verotoxin / glomeruli restricted hemolytic uremic syndrome pathology. Kidney International
2009;75:1209-1216. 44. Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Cotting J, Gottesman R, Joffi A,
Pfeinnenger J, Hubert P, Martinot A, Lacroix J, Leclerc F. Daily estimation of the multiple organ dysfunction syndrome in critically ill children. CMAJ 2010; 182(11): 1181-1187.
45. Bestati N, Leteurtre S, Duhamel A, Proulx F, Grandbastien B, Lacroix J, Leclerc F.
Differences in organ dysfunctions between neonates and other children: a prospective, observational, multicentre study, Crit Care 2010;R202:1-9.
46. Proulx F, Lemson J, Choker G, Tibby S. Hemodynamic monitoring by transpulmonary
thermodilution and pulse contour analysis in critically ill children. Pediatr Crit Care Med 2011; 12(4):459-66.
47. Proulx F, Lemson J, Choker G, Tibby S. Hemodynamic monitoring by pulse contour analysis
in critically ill children with congenital heart disease. Pediatr Crit Care Med 2011; 12(5):609-10.
48. Lapeyraque AL, Malina M, Fremeaux-Bacchi V, Boppel T, Kirschfink M, Qualha M, Proulx F, Clermont MJ, Le Deist F, Niaudet P, Schaefer F. Eculizumab in severe Shiga-
toxin-associated HUS. N Engl J Med 2011; 364(26):2561-3. 49. Proulx F, Guilemette J, Roumeliotis N, Emeriaud G. Organ weights at autopsy in critically ill
children. Pediatr Dev Pathol . In Press 2015 50. Villeneuve A, Joyal JS, Proulx F, Ducruet T, Poitras N, Lacroix J. Multiple organ
dysfunction syndrome in critically ill children: diagnostic value of two definitions. Pediatr Crit Care Med (en soumission).
51. Baudin F, Gagnon S, Crulli B, Proulx F, Jouvet P, Émeriaud G. Safety and modalities of
use of high flow nasal canula : Experience in a pediatric intensive care unit. (en soumission).
Scientific Publications (other than in peer reviewed Journal) 1. Proulx F. Convulsiones e hipertensiøn en ninos. Salud (i) Cienca 1994;5:10. 2. Chartrand L, Proulx F. Alerte à Escherichia coli O157:H7. Actualité Médicale, Juin 97,
18:56-57. 3. Chartrand L, Létourneau J, Proulx F. La maladie du Hamburger. Enfants Québec, Juin 97,
9:128-129.
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4. Proulx F, Boeuf B, Lacroix J. Pediatric multiple organ dysfunction syndrome. Intensive
Care World 1997;14:79-82. 5. Proulx F, Dugas MA, Boeuf B, Lacroix J. Le syndrome de défaillance multiviscérale chez
l'enfant. Médecine Thérapeutique. 1998;1:427-433 6. Lacroix J, Proulx F. Multiple organ dysfunction syndrome. VII Congresso Brasiliero,
Terapia Intensiva Pediatrica. 1998 7. Lacroix J, Proulx F. Multiple organ dysfunction syndrome. IV European postgraduate
course in neonatal and pediatric intensive care. Bern, March 11-13, 1999. 8. Proulx F, Mariscalco MM, Seidman E, Lee K; and Caroll SF. Increased circulating levels
of lipopolysaccharide binding protein in children with Escherichia coli O157:H7 hemorrhagic colitis and hemolytic uremic syndrome. Glycobiology Research publication. 1999. www.shef-ac-press.co.uk/subis
9. Despond O, Proulx F, Carcillo JA, Lacroix J. Pediatric sepsis and multiple organ
dysfunction syndrome. Curr Opin Pediatr 2001;13:247-253. 10. Proulx F, Sockett P. Prospective surveillance of Canadian children with hemolytic uremic
syndrome. Canadian Pediatric Surveillance Program, April, 2001. http://www.hc-sc.gc.ca/pphb-dgspsp/publicat/cpsp-pcsp01/index.html
11. Proulx F, Sockett P. Prospective surveillance of Canadian children with hemolytic uremic
syndrome. Canadian Pediatric Surveillance Program, Health Canada; June, 2002. 12. Armano R, Proulx F, Toledano B, Lacroix J. Le syndrome de défaillance multiviscérale
pédiatrique en salle d’urgence. Urgence Pratique 2002; 53 :11-14. 13. Armano R, Proulx F, Toledano B, Lacroix J. An update on pediatric multiple organ
dysfunction syndrome. Recent Res Devel Resp Critical Care Med 2002;2 :83-101. 14. Proulx F, Sockett P. Prospective surveillance of Canadian children with hemolytic uremic
syndrome. Canadian Pediatric Surveillance Program, Health Canada; June, 2003 http://www.cps.ca/francais/proadv/PCSP/2002%20Resultats.pdf
15. Le syndrome de défaillance multiviscérale chez l’enfant: étiopathogénie. Lacroix J, Proulx
F. Actualité en réanimation et urgences 2007; 580-591 16. Proulx F. Book review for Journal of Pediatric Intensive Care; 2013: Infections in the
Intensive Care Unit. Saene HK, Silvestri L, De la Cal, MA, Gullo, A. Springer Verlag. Third Edition. ISB9788847016002
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Chapters of book:
1. Proulx F, Hébert D, Lacroix J. Hypertensive crisis. In: Lacroix J, Gauthier M, Beaufils F. Ed. Urgences et soins intensifs pédiatriques. Une approche clinique multidisciplinaire. Paris: Presses de l'Université de Montréal, Doin 1994:651-69.
2. Simon L, Farrell CA, Lacroix J, Proulx F, Toledano B, Piva JP, Garcia PCR. Sepse e
Sindrome da resposta inflamatoria systemica (SRIS). In: Piva JP, Garcia PCR (eds). Terapia intensive pediatrica. Rio de Janiero. Editora Medsi, Septembre 2004 ; pp: 103-134.
3. Proulx F, Loirat C, Ramet J, Hébert MJ. Syndrome hémolytique urémique et purpura
thrombocytopénique. In: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier-Masson, 2007 : 745-759.
4. Proulx F, Leteurtre S, Leclerc F, Lacroix J, van Den Bergh G, Vanasse M. Le syndrome de
défaillance multiviscéral. In: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P. (eds). Montréal et Paris. Urgences et soins intensifs pédiatriques. Éditions du CHU Sainte-Justine et Elsevier-Masson, 2007 : 143-165.
5. De Cléty SC, Gordon JB, Proulx F, Beghtti M. Hypertension pulmonaire. In: Lacroix J,
Gauthier M, Leclerc F. Ed. In: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P. (eds). Montréal et Paris. Urgences et soins intensifs pédiatriques. Éditions du CHU Sainte-Justine et Elsevier-Masson, 2007 : 467-481.
6. Leclerc F, Lacroix J, Proulx F, Tapiero B, Hazelzet J. Sepsis et choc septique. In: Lacroix
J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Montréal et Paris. Urgences et soins intensifs pédiatriques. Éditions du CHU Sainte-Justine et Elsevier-Masson, 2007 : 211-240.
7. Proulx F, Tesh VL. Hemolytic uremic syndrome and related thrombotic
microangiopathies. In: Weeler DS, Wong HR, Shanley TP. Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. London: Springer-Verlag. 2007; 1189-1203.
8. F Proulx, MJ Clermont. Syndrome hémolytique et urémique; p. 1203-1205. In: Turgeon J,
Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M, éd. Dictionnaire de thérapeutique pédiatrique Weber. 2e éd. Montréal: Gaétan Morin éd, 2007:1490p.
9. F Proulx, J Miro. Choc cardiogénique; p.265-271. In: Turgeon J, Bernard-Bonnin AC,
Gervais P, Ovetchkine P, Gauthier M, éd. Dictionnaire de thérapeutique pédiatrique Weber. 2e éd. Montréal: Gaétan Morin éd, 2007:1490p.
10. F Proulx, P Ovetchkine, B Tapiero. Choc septique; p.277-284. In: Turgeon J, Bernard-
Bonnin AC, Gervais P, Ovetchkine P, Gauthier M, éd. Dictionnaire de thérapeutique pédiatrique Weber. 2e éd. Montréal: Gaétan Morin éd, 2007:1490p.
11. A Mérouani, F Proulx, AC Bernard-Bonnin. Hypertension artérielle; p.621-628.
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In: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M, éd. Dictionnaire de thérapeutique pédiatrique Weber. 2e éd. Montréal: Gaétan Morin éd, 2007:1490p.
12. F Proulx, J Turgeon, JB Girodias. Obstruction aiguë des voies respiratoires supérieures d’origine infectieuse; p. 934-938. In: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M, éd. Dictionnaire de thérapeutique pédiatrique Weber. 2e éd. Montréal: Gaétan Morin éd, 2007:1490p.
13. F Proulx, S Leteurtre, JS Joyal, P Jouvet. Multiple organ dysfunction syndrome;In: Weeler
DS, Wong HR, Shanley TP. Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 2nd Edition / Volume 1: Care of the critically ill or injured child London: Springer-Verlag. 2014; 457-473.
14. F Proulx, B Tapiero. Choc septique; p. 232-238 In: Turgeon J, Hervouet-Zeiber C,
Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015: 1366 p.
15. F Proulx, J Miro. Choc cardiogénique; p. 220-225. In: Turgeon J, Hervouet-Zeiber C,
Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015:1366 p.
16. F Proulx, M Sanchez, J Turgeon. Obstruction aiguë des voies respiratoires supérieures
d’origine infectieuse; p. 824-829. In: Turgeon J, Hervouet-Zeiber C, Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015:1366 p.
17. F Proulx, AL Lapeyraque, M Saint-Jean. Syndrome hémolytique urémique; p. 1097-1099.
In: Turgeon J, Hervouet-Zeiber C, Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015:1366 p.
18. A Mérouani, F Proulx, AC Bernard-Bonnin. Hypertension artérielle; p. 534-540.
In: Turgeon J, Hervouet-Zeiber C, Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015: 1366 p.
19. A Lévy, F Proulx. Choc hypovolémique non hémorragique; p. 230-231. In: Turgeon J,
Hervouet-Zeiber C, Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015:1366 p.
20. C Litalien, V Phan, I Chevalier, F Proulx. Déséquilibre hydriques et électrolytiques; p.
318-339. In: Turgeon J, Hervouet-Zeiber C, Ovetchkine P, Bernard-Bonin AC, Gauthier M, éds. Dictionnaire de pédiatrie Weber. 3e éd. Montréal: Gaétan Morin éd, 2015:1366 p.
Page 16 de 23
Fellowships and Grants 1. Proulx F. Fellowship from the Ross Company joined to the Sainte-Justine Hospital.
"fonds des PTG", 1992-1993, 40,000.$/year. 2. Proulx F, Lambert M, Lacroix J, Qureshi IA. Acquired carnitine deficiency in Pediatric
Intensive Care. Grant from le club de services Sainte-Justine Hospital, telethon of stars, 4,160.$/year.
3. Proulx F, Turgeon J, Seidman E. Inflammatory mediators in hemorrhagic colitis and
hemolytic uremic syndrome. Grant from le club de services Sainte-Justine Hospital, telethon of stars, 1993-1994, 16,169.$/ year.
4. Proulx F, Turgeon J, Seidman E. Soluble leucocyte adhesion molecules in hemorrhagic
colitis and hemolytic uremic syndrome. Grant from le club de services Sainte-Justine Hospital, telethon of stars, 1994-1995, 7,200.$/year.
5. Proulx F. The assessment of plasma carnitine as a marker of cellular dysoxia among
children with sepsis. Grant from le club de services Sainte-Justine Hospital, telethon of stars, 1995-1996, 10,000.$/year.
6. Proulx F. The role of plasma carnitine as a marker of cellular respiratory insufficiency in
children with sepsis. Prix SPECIA. Grant from la Société de Réanimation de Langue Française, 1994-1996, 50,000 francs/year for 2 years.
7. P. McLaine and collaborators from the CPKDRC (Proulx F, Turgeon JP). A phase II
study of Synsorb Pk as an oral agent for the prevention of HUS. Granted by the Alberta Research Council Biotechnology, 1994-1996, 800,000.$/year for 2 years.
8. Proulx F, Turgeon JP, Seidman E. Th-1 and Th-2 responses in hemorrhagic colitis and
hemolytic uremic syndrome. Granted by le Fonds d'opération pour la recherche clinique, épidémiologique et évaluative. 1997-1998. $22,804/year for 1 year.
9. Lacroix J, Déry C, Lebel P, Guertin MC, Moghrabi A, Farrell CA, Proulx F.
Reproductibilité de la culture quantitative des sécrétions respiratoires obtenues par un lavage bronchoalvéolaire fait sous bronchoscopie chez l'enfant intubé. Grant from le club de services Sainte-Justine Hospital, telethon of stars, 1995-1996, 9,600.$
10. Lacroix J, Bonnin P, Proulx F, Delvin E. Analyse du surfactant recueilli par lavage
bronchoalvéolaire: valeur pour le diagnostic du syndrome de détresse respiratoire aigue. Grant "Fondation de l'Hopital Sainte-Justine, 1996-1998, 7600/an $
11. Proulx F, Sockett P. Prospective surveillance of Canadian children with Hemolytic uremic
syndrome. Grant from the Laboratory Centre for Diseases Control-Canadian Pediatric Surveillance Program, 2000-2002 ($25,000 for 2 years).
Page 17 de 23
12. Proulx F, Palermo M, Toledano B, Fournet JC, Patey-Meriaud N, Gulati S. The fractalkine pathway in children with E. coli associated hemolytic uremic syndrome. Ste-Justine Hospital Research Centre. 2002-2003 ($15,000 for 1 year).
Tasks in Academic education: A-) Undergraduate medical students, pediatric residents, critical care fellows,
pediatricians: Several tasks in clinical teaching from 1994 to 2105, including: 1. Director of Marc-André Dugas thesis (MSc). Markers of cellular dysoxia in children with
sepsis and mulptiple organ dysfunction." 1997-1998. Thesis accepted, December 2002. 2. Board Examinator for the Royal College of Physicians and Surgeons of Canada,
examination board of Pediatrics, 1998-2000. 3. Board examinator for fellows in pediatric critical care medicine from Ste-Justine Hospital,
and the Montreal Children’s Hospital; 2001, 2002, 2005, 2006, 2007. 4. Pediatric advanced life support (PALS), Workshop. 1993-1995; 1998. 5. Update in pediatrics. Pediatric septic shock. 1994 6. Update on Multiple organ dysfunction syndrome in children. 1994. 7. Update in Pediatric Intensive Care. 1996. 8. Member of Jury, MSc (CHAC23576706). Incidence, facteurs et marqueurs de rique ds
thromboses liées aux cathéters veineux centraux en soins intensifs pédiatriques. 1998. 9. Member of Jury, MSc (CHAM01126400). Les hémorragies gastroduodénales de stress
cliniquement significatives acquises en soins intensifs pédiatriques.1998. 10. Course to critical care fellows and pediatric residents on pulmonary hypertension after
cardiac surgery. 2001. 11. Course to critical care fellows and pediatric residents on the systemic inflammatory
response syndrome and the multiple organ dyfsunction syndrome. 2001. 12. Course to critical care fellows on the pediatric multiple organ dysfunction syndrome and
septic shock. 2006. 13. Course to critical care fellows on pupura fulminans. 2007 and 2009. 15. President of Jury MSc SANM27537707. Étude multicentrique sur les stratégies de
ventilation mécanique employées chez les enfants avec un œdème pulmonaire lésionnel. 2009.
Page 18 de 23
16 Course to critical care fellows on multiple organ dysfunction syndrome. 2010. 17. Course to critical care fellows on septic shock SIN8102. 2011. 18. Course to pediatric residents on septic shock. 2012. 19. Course to critical care fellows on transpulmonary thermodilution and pulse contour cardiac
output SIN8102; 2013. 20. ECOS for pediatric residents 2013-2015. 21. Course to pediatric residents on septic shock. 2015. B-) Peer-reviewed Journals and subventionary organisms (FRSQ, HSCF, CIHR, CERG) 1. Reviewer of the article by Heyinh R et al. Mid-term follow-up after multiple organ
dysfunction syndrome following cardiac surgery. Acta paediatrica 1998. 2. Reviewer of the article by Takaaki Kurioka, Yoshihisa Yunou, Hiroko Harada and Eiji
Kita. Efficacy of antibiotic therapy for infection with Shiga-like toxin producing Escherichia coli O157:H7 in mice with protein-calorie malnutrition. European Journal of Clinical Microbiology and Infectious Diseases. 1999. MS#98/455.
3. Reviewer of the article by P Chetaille, O Paut, A Fraisse, B Kreitmann, P Camboulives, JF
Pellissier. Acute myopathy of intensive care in a child after heart transplantation. The Journal of Heart and Lung Transplantation. 1999. MS#001739.
4. Reviewer of an MRC grant proposal by D Payen (60434) Septembre 1999. Mise en
évidence de l'immuno-dépression post aggressive des patients présentant un syndrome de réponse inflammatoire systémique: aspects cinétiques et mécanistiques: impact sur la survenue d'infections nosocomiales.
5. Reviewer of the Article by McMaster C, et al. Outbreak of Escherichia coli O26:H11 in an
Irish Creche. Eur J Clin Microbiol Infect Dis 2000. Ms#00/360. 6. Reviewer of the Grant proposal entitled: Model of endothelial cell-to-cell communication
in cells, by Yves Ouellette XG 01-087; December, 2000. The Hospital for Sick Children Foundation.
Page 19 de 23
7. Reviewer of the article entitled: sFas and sFas-L and pediatric sepsis-induced multiple organ failure syndrome. By L Doughty, RSB Clark, SS Kaplan, H Sasser, SR Wismiewski And J Carcillo. Dec 2000 Pediatr Res MS#00-112328.
8. Reviewer of the article entitled: Basic fibroblast growth factor in children with diarrhea
associated hemolytic uremic syndrome. By P Ray, D Acheson. June 2001 JASN MS#2001/004061.
9. Reviewer of the manuscript entitled: Escherichia coli O157:H7 transmission from dairy
farms verified by pheno- and genotyping. By E. Lahti, Eklund M, Slitonen A, et al. August 2001. Eur J Clin Microbiol Infect Dis. MS#01/284.
10. Reviewer of the article entitled : Effect of nitric oxide on platelet function with respiratory
failure, by Saving KL, Mankin PE, Hocker JR, Russell T. March 2001, Intensive Care Med, MS no 21464.
11. Reviewer of the article entitled: Clostridium difficile colitis associated with the hemolytic
uremic syndrome, by C Chibundu Mbonu, et al, May 31, 2002, Am J Kid Dis, MS no 02-00348.
12. Reviewer of the article entitled: Blood transfusion among European pediatric intensive care
physicians, by Nahum E, Ben-Ari J, Schonfeld T. Intensive Care Medicine 2002. MS No 22010.
13. Reviewer of the article entitled: Verocytotoxin-producing Escherichia coli in patients with
diarrhea: A case study in Switzerland, by Schmid H, Burnes AB, Baumgartner A, Boerlin P, Bille J, Liassine N, Friderich P, Beer C. Eur J Clin Microbiol Infect Dis . 2002. MS No 02/246.
14. Reviewer of the article entitled: Benefits of subcutaneous administration of epinephrine in
treating sepsis, by Dur-Zong Hsu, et al. Crit Care Med 2002. CCM 00711-2002. 15. Reviewer of the article entitled: Verocytotoxin-producing Escherichia coli in patients with
diarrhea: A case study in Switzerland, by Schmid H, et al. Eur J Clin Microbiol Infect Dis 2002. MS 02/246.
16. Reviewer of the article entitled : Characterization of the immune response in children after
typical hemolytic uremic syndrome, by S Westerholt, et al. Clinical Diagnostic Laboratory Immunology 2002. CDLI/163-02.
17. Reviewer of the article entitled: Von Willebrand factor may help differentiate between the
inflammatory responses following surgery and sepsis, by A Hoskote et al, Intensive Care Medicine 2002, No 22146.
18. Reviewer of the article entitled: Attempted treatment of hemolytic uremic syndrome with
factor H deficiency by liver transplantation, by Cheong et al, American Journal Kidney Diseases, 2003, AJKD-D-03-00031.
Page 20 de 23
19. Reviewer of the article entitled: Shiga toxin-producing Escherichia coli and the hemolytic uremic syndrome, by Tarr P, Gordon CA, Chandler WL. Lancet, 2003.
20. Reviewer of the article entitled: Arginine-vasopressin is associated with a favorable
increase in blood pressure in children with septic shock by Thomas J. Starc, Erica Berman Rosenzweig, Donald W. Landry, et al. Crit Care Med 00424-2003.
21. Reviewer of the article: Invasive Streptococccus pneumoniae causing hemoylitic uremic
syndrome in children: two cases and a review of the literature, by Vanderkooi OG, et al. Can J Infect Dis 2003. Ms 03/011.
22. Reviewer of the article: Evaluation of procalcitonin as marker of infection in a non selected
sample of febrile hospitalized patients, by Munoz P, et al. Eur J Clin Microbiol Infect Dis, 2003. MS 03/269.
23. Reviewer of the article : The role of circulating immune complexes and biocompatibility of
Staphylococcal protein A immunoadsorption in mitomycin C-induced hemolytic uremic syndrome, by B Mistry et al. Am J Kidney Dis 2003 AJKD-D-03-00965.
24. Internal reviewer for the FRSQ. Subventions à la recherche clinique, radiologie,
traumatologie, et hémovigilance. SAM J08801; SWAB 09001; DIAMA 0302; Febuary16, 2004.
25. Reviewer of the article : Isolation of Toxigenic Hafnia alvei from a Case of Hemolytic
Uremic Syndrome, by Crandall C, et al. Emerging Infectious Diseases 2005 EID-05-0312. 26. Reviewer of the article: Evaluation of organ dysfunctions in children admitted to the
pediatric intensive care unit, by RG Branco, et al Pediatr Crit Care Med PCCM-00091-2005.
27. Reviewer of the article: Proteinomics used to identify the target of a platelet aggregating
antibody in a patient with HUS. 2005; Rock G, et al Am J Kid Dis-D-05-00584. 28. Reviewer of the article: Outocmes of critically ill children requiring continuous renal
replacement; Hayes LW, et al. Crit Care Med 2006 CCM-00138-2006. 29. Reviewer of the artcile: Mortality rate in onco-pediatric septic shock; Filho JOP, et al;
Pediatr Crit Care Med; PCCM-00205-2005. 30. Reviewer of the article: ARDS complicating a case of classic hemolytic uremic syndrome; J
of Postgraduate Medicine; 2006; JPGM-162-06. 31. Reviewer of the article: Bacterial enteric infections in children: etiology, clinical
manifestations, and antimicrobial therapy. 2006. Expert review of anti-infective therapy. 32. Reviewer of the article: Persitent gastrointestinal tract infection caused by a binary toxin
positive Clostridium difficile strain in a 2 year old female with hemolytic uremic syndrome of unknown etiology, by Wultanska D, et al; Pediatr Nephrol 2006; 06-05-0260.
Page 21 de 23
33. Reviewer of the article: Fas expression on peripheral T cells in children with Escherichia
coli O157:H7-associated hemolytic uremic syndrome, by Chen-Yin Chen et al; Renal Failure 2006; MS04117.
34. Reviewer of the article entitled: Changes on outcomes (1996-2004) for pediatric oncology
and HSCT patients requiring mechanical ventialtion, by R Tamburro, et al; Pediatr Crit Care Med 2007; MS PCCM-00025-2007.
35. Reviewer of grant proposal, entitled: Analysis of a fimbrial adhesin identified in Shiga
toxin-producing Escherichia coli , by Dr Leung, Polly Hang-Mei (PI) and Yam , WC (co-applicanty); Grant submitted to the Hong Kong Research Grant Council, 2007; RGC 561807.
36. Reviewer of the article entitled: Serum Neutrophilgelatinase-associated lipocalin (NGAL)
as a marker of acute kidney injury in critically ill children with septic shock, by Wheeler DS et al. CCM 01143-2007
37. Reviewer of the article entitled: Shiga toxin 1 induces apoptosis through the ER stress
response in human monocytic cells. Cellular Microbiology; CMI-07-0397. 38. Traduction of the article entitled: Reduction of catheter associated bloodstream infection in
pediatric patients: Experimentation and reality; PCCM-0319-2007. 39. Traduction of the article entitled: Neurological injury markers in children with septic shock.
Hsu AA, et al. PCCM-000460-2007 40. Reviewer of the article entitled: Children with chronic illness return to their baseline
functional status after organ dysfunction in the pediatric intensive care unit. Typo et al PCCM; MS# 20091035
41. Reviewer of the article entitled: Stress ulcer prophylaxis in five brazilian intensive care
unit; by Aruajo, TE et al PCCM-D-10-00060. 42. Reviewer of the article entitled: Kawasaki disease: An unexpected etiology of shock and
multiple organ dysfunction syndrome, by P Gatterre et al; PCCM-D-10-00484 43. Reviewer of the article entitled: Cytokines production is altered in monocytes from children
with hemolytic uremic syndrome. PedNeph 11-01-0058. 44. Reviewer of the article entitled: Toll-Like receptor 4 expression on circulating leucocytes in
haemolytic uremic syndrome. PedNeph-11-04-0222 45. Reviewer of the article entitled: Effects on cardiac output of lung recruitment guided by
tidal elimination of CO2 and dynamic compliance. PCCM-D-11-00170 46. Reviewer of the article entitled: Preservation of renal function in atypical Hemolytic
Uremic Syndrome by Eculizumab. A case report. Pediatrics 2011-1685, by Ahmet A, et al
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47. Reviewer of the article entitled: Acute adrenal insufficiency: An unusual course with lesson
about therapy. Paediatric & Child Health. 2012-CR-12-0012 48. Reviewer of the article: Peripheral gangrene in children with atypical hemolytic uremic
syndrome. Pediatrics 2012-0903 49. Reviewer of the article entitled: Extravascular lung water measured by single
transpulmonary thermodilution correlates poorly with gravity in a pediatric lung injury model. Pediatr Crit Care Med –D12-00327
50. Reviewer of the article entitled: Diagnosis of Streptococcus pneumonia associated HUS: a
plea for determination of T activation. Pediatric Infect Dis J – PIDJ 212-1106 51. Editor Book review for Journal of Pediatric Intensive Care. 2013. 52. Reviewer of the article entitled: The use of dornase alpha for postoperative pulmonary
atelectasis after congenital heart surgery. 2013 – PCCM-2-13-00049. 53. Reviewer of the article entitled: Therapeutic role for Anakinra, an IL-1 receptor antagonist
in decreasing the systemic inflammation associated with the spectrum of hemophagocytic lymphohistiocytosis, by Rajasekaran S, et al. 2013 - PCCM-D-13-00213.
54. Reviewer of the article entitled: Development and validation of a bedside prediction score
for nosocomial sepsis in a pediatric intensive care unit – a prospective observational cohort study, by Lalgudi Ganesan Saptharishi et al. 2014 PCCM-D-14-0071.
Presentation in national or international meetings: None Invited lecturer: None Participation to committees at the provincial national or international level: None. Honors: None. Membership to Scientific Society: 1. Society of Critical Care Medicine, 1993-2002. 2. Active member of Research Centre of Sainte-Justine Hospital 1993-2009.
Page 23 de 23
3. Member of the Royal College of Physicians and Surgeons of Canada, 1997-2002. 4. Member of the Canadian Intensive Care Fundation, 2000-2009. 5. Member of the Société de Réanimation de Langue Française, 2004-2005. 6. Member of the Society of Intensive Care of Quebec, 2004-2015.
