CURRICULUM VITAE of RITA LOCH-CARUSO, Ph.D. · PDF fileCURRICULUM VITAE of RITA LOCH-CARUSO, Ph.D. CURRENT EMPLOYMENT Address: Department of Environmental Health Sciences, School of

CURRICULUM VITAE of

RITA LOCH-CARUSO, Ph.D.

CURRENT EMPLOYMENT

Address: Department of Environmental Health Sciences, School of Public Health, University of

Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029

Phone: (734) 936-1256

Email: [email protected]

PERSONAL

Home Address: 556 Glendale Circle, Ann Arbor, MI 48103

Home Phone: (734) 668-0497

Citizenship: U.S.A.

EDUCATION

1972-1976 University of Cincinnati, Cincinnati, OH. B.S. in Biology and B.A. in Psychology (1976).

1976-1982 Department of Environmental Health, University of Cincinnati, Cincinnati, OH. Ph.D. in

Toxicology (1982).

PROFESSIONAL APPOINTMENTS

1975-1976 Research Assistant, Department of Environmental Health, University of Cincinnati,

Cincinnati, OH.

1982-1984 Postdoctoral Fellow, Department of Pediatrics and Human Development, Michigan State

University, East Lansing, MI.

1984-1986 Assistant Professor, Department of Pediatrics and Human Development, Michigan State

University, East Lansing, MI.

1986-1993 Assistant Professor, Toxicology Program, Department of Environmental and Industrial

Health, School of Public Health, University of Michigan, Ann Arbor, MI.

1993-2001 Associate Professor, Toxicology Program, Department of Environmental Health

Sciences, School of Public Health, University of Michigan, Ann Arbor, MI.

1994-2006 Research Associate Scientist, Reproductive Sciences Program, University of Michigan,

Ann Arbor, MI.

1999-2003; Director, Environmental Toxicology Pre- and Post-Doctoral Research Training Program,

2008-2010 University of Michigan, Ann Arbor, MI.

2003-2008 Associate Director, Environmental Toxicology Pre- and Post-Doctoral Research Training

Program, University of Michigan, Ann Arbor, MI.

2004-05 Interim Chair, Department of Environmental Health Sciences, School of Public Health,

University of Michigan, Ann Arbor, MI.

2005 (Nov) Acting Chair, Department of Environmental Health Sciences, School of Public Health,

University of Michigan, Ann Arbor, MI.

Curriculum Vitae Rita Loch-Caruso

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1999-2002; Director, Toxicology Program, Department of Environmental Health Sciences, School of

2010-present Public Health, University of Michigan, Ann Arbor, MI.

2001-present Professor, Toxicology Program, Department of Environmental Health Sciences, School

of Public Health, University of Michigan, Ann Arbor, MI.

2003- present Faculty Associate, Program in the Environment, College of Literature, Science & the

Arts, University of Michigan, Ann Arbor, MI.

2010- present Director, Environmental Toxicology and Epidemiology Program, University of

Michigan, Ann Arbor, MI

CURRENT RESEARCH INTERESTS

Mechanisms of abnormal parturition, focusing on toxicant stimulation of uterine, placental and

extraembryonic membranes; mechanisms of infectious and noninfectious inflammation in extraembryonic

membranes; oxidative stress as a mechanism of reproductive and developmental toxicity; toxicant

modification of bacterial infection of the gestational compartment.

RESEARCH GRANTS

Active

1. NIH/NIEHS 1R01 ES014860 (Rita Loch-Caruso, Principal Investigator). Mechanisms of

Inflammation in Gestational Membranes. September 9, 2008-May 31, 2013.

2. NIH/NIEHS P42 ES017198. (Rita Loch-Caruso, Project #2 Principal Investigator). Pollutant

Activation of Cell Pathways in Gestational Tissues. (A. Alshawabkeh, Center Principal

Investigator; Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)). April 12,

2010 – March 31, 2014.

3. NIH/NIEHS P42ES 017818 (John Meeker, Project #3 Principal Investigator). Phthalate

Exposure and Mechanistic Pathway Markers in Preterm Birth among Women in Puerto Rico.

(A. Alshawabkeh, Center Principal Investigator; Puerto Rico Testsite for Exploring

Contamination Threats (PRoTECT)). April 12, 2010 – March 31, 2014.

4. NIH/NIEHS R01 ES 018872 (John Meeker, Principal Investigator). Bisphenol A and Phthalate

Exposure in Relation to Fetal Growth and Preterm Birth. October 1, 2010 – May 31, 2015.

5. NIH/NIEHS P30 ES017885 (Howard Hu, Principal Investigator). Lifestage Exposures and

Adult Disease. April 1, 2011 – February 28, 2015.

Pending

1. GAPPS/Gates Foundation (Grant # not assigned) (David Aronoff, Principal Investigator).

Mechanisms of Group B Streptococcal Interactions with Extraplacental Membranes. Under

review.

2. NIH/NIAID/NICHD (Grant # not assigned) (David Aronoff, Principal Investigator). Mechanisms

of Group B Streptococcal Interactions with Extraplacental Membranes.

Completed

1. NIOSH/CDC #0H00024 (R. Loch-Caruso, Principal Investigator). Project title: Role of Inhibited

Junctional Communication in Reproductive Dysfunction. September 1, 1984 to August 31,

1987.


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2. March of Dimes #15-79 (R. Loch-Caruso, Principal Investigator). Project title: Alteration of

Myometrial Cell-Cell Communication by Industrial Compounds. February 1, 1986 to May 31,

1988.

3. University of Michigan Rackham Faculty Research Award (R. Loch-Caruso, Principal

Investigator). Project title: Effects of Metals on Gap Junctional Communication. May 1, 1987

to April 30, 1988.

4. NIH #R29 ES04424 (R. Loch-Caruso, Principal Investigator). Project title: Cell-Cell

Communication in Myometrial Cultures. September 1, 1987 to August 31, 1993.

5. University of Michigan Research Partnership Award (R. Loch-Caruso, Principal Investigator).

Project title: Modification of Cell Growth by Inhibition of Gap Junctional Communication using

Antisense RNA. May 1, 1989 to April 30, 1990.

6. Office of the Vice President for Research of the University of Michigan #135347 (R. Loch-

Caruso, Principal Investigator). Project title: cDNA and Antibody Production for the Study of

Myometrial Gap Junctions. January 1, 1990 to December 31, 1991.

7. Office of the Vice President for Research of the University of Michigan (R. Loch-Caruso,

Principal Investigator). Project title: Microinjection System for Toxicant Studies. June 1, 1991

to September 30, 1991.

8. NIH #2P42 ES04911 (Lawrence Fischer, Program Project Principal Investigator). Program

project title: Health Hazards from Groundwater Contamination. April 1, 1992 to March 31,

1995. (R. Loch-Caruso, Subproject Investigator. Subproject title: Modulation of Myometrial

Gap Junctions and Uterine Contractility by Chlorinated Aliphatic and Aromatic Hydrocarbons.)

9. NIH #1R01 ES05235 (C. Harris, Principal Investigator). Project title: Glutathione Interactions

in Chemical Toxicity. (R. Loch-Caruso, Co-Principal Investigator). July 1, 1994 to June 30,

1998.



2000. (R. Loch-Caruso, Project Investigator. Project title: PCB Effects on Uterine Muscle.)

11. NIH #1R01 ES06915 (R. Loch-Caruso, Principal Investigator). Project title: Lindane

Modification of Uterine Muscle. July 1, 1994 to June 30, 1999 (no-cost extension July 1, 1999

to June 30, 2004). Total Direct Costs: $745,428.



2006. (R. Loch-Caruso, Project Investigator. Project title: PCB Effects on Uterine Muscle.)

13. University of Michigan Elizabeth C. Crosby Research Award (R. Loch-Caruso, Principal

Investigator). Mechanisms of Toxicant-Induced Alteration of Parturition. May 1, 2005-April

30, 2006.

14. University of Michigan NIH Reoadmap Disparities Center Pilot Grant (R. Loch-Caruso,

Principal Investigator). Phthalate Activation of the Inflammatory Pathway in Adverse Birth

Outcomes. May 1, 2006 – December 31, 2007.

15. Society of Toxicology Colgate-Palmolive Grant for Alternative Research (R. Loch-Caruso,

Principal Investigator). In Vitro Models to Assess Toxicant Actions in Human Gestational

Membranes. January 1, 2007-December 31, 2007 (no cost extension to August 31, 2008).


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16. University of Michigan Department of Environmental Sciences Pilot Grant Program (C. Xi,

Principal Investigator). Biofilms and Microbial Intrauterine Infection in Preterm Birth. June 1,

2007-May 31, 2008.

17. University of Michigan Pilot and Collaborative Grant Program for Translational and Clinical

Research (R. Loch-Caruso, Principal Investigator). Inflammation in Human Gestational

Membranes. September 1, 2007-August 31, 2008 (no cost extension to March 1, 2009).

18. University of Michigan Department of Environmental Sciences Pilot Grant Program (R. Loch-

Caruso, Principal Investigator). Phthalates, Inflammation and Preterm Birth. June 1, 2007-open.

19. University of Michigan Office of the Vice President for Research and the School of Public

Health (R. Loch-Caruso, Principal Investigator). Biofilm Formation in Extra-Placental

Gestational Membranes. September 1, 2008-June 30, 2009.

TRAINING / INSTRUCTIONAL GRANTS

Active

1. NIH #T32 ES07062 (Rita Loch-Caruso, Principal Investigator, 10% effort). Project title:

Environmental Toxicology an Epidemiology Research Training. July 1, 2010 to June 30, 2015.

Completed

1. University of Michigan Gilbert Whitaker Fund for the Improvement of Teaching (R. Loch

Caruso, Principal Investigator). Training Environmental Health Professionals. December 1,

1997 to November 30, 1998.

2. NIH #T32 ES07062 (Rita Loch Caruso, Principal Investigator, 10% effort). Project title:

Environmental Toxicology Pre/Post-doctoral Research Training. July 1, 1995 to June 30, 2000.

3. NIH #T32 ES07062 (Rita Loch Caruso, Principal Investigator, 10% effort). Project title:

Environmental Toxicology Pre/Post-doctoral Research Training. July 1, 2000 to January 30,

2003.

4. NIH #T32 ES07062 (Rita Loch-Caruso, Principal Investigator, 10% effort). Project title:

Environmental Toxicology Pre/Post-doctoral Research Training. July 1, 1995 to June 30, 2000.

OTHER GRANTS

1. University of Michigan Career Development Award (R. Loch Caruso). November 1, 1995 to

October 31, 1996. Total Direct Costs: $5,000.

OTHER AWARDS AND HONORS

1. McMicken Scholars Honors Society, University of Cincinnati, 1972-1976.

2. Cum Laude, University of Cincinnati, 1976.

3. Honors in Psychology, University of Cincinnati, 1976.

4. Grass Foundation Award in Neurobiology, 1976.

5. NATO Travel Award to attend NATO conference in Monte Carlo, Monaco, 1979.

6. Young Investigators Award, Teratology Society, 1982.

7. NSF Travel Award to attend NATO Advanced Study Institute in Banyuls-sur-Mer, France, 1984.

8. High Honors List of Instructors at the University of Michigan, 1991.


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TEACHING ACTIVITIES

1984-1985 Michigan State University. Lectured in Introduction to Chemical Toxicology on Basic

Science Course on reproductive and developmental toxicology.

1985-1996 University of Michigan. Lectured in Introduction to Toxicology, Occupational

carcinogenesis, teratogenesis, and reproductive toxicology.

1985-1990 Michigan State University. Lectured in Obstetrics and Gynecology Toxicology, and

Introductory Seminar in Toxicology on various topics, including reproductive,

developmental, genetic, and renal toxicology.

1986 University of Michigan. Lectured in Tissue Culture Methods in Public Health Practice

on mycoplasma contamination.

1986 University of Michigan. Lectured in Essentials of Toxicology on genetic toxicology.

1986-1993 University of Michigan. Developed and taught one section of Molecular Mechanisms of

Environmental Toxicology. Named to the "High Honors List" of instructors at the

University of Michigan for the Fall Term of 1991 by the Michigan Student Assembly.

1987 University of Michigan. Lectured in Methods in Toxicology on developmental toxicity

testing.

1990-1994,

1999, 2000 University of Michigan. Course organizer of Introductory Seminar in Toxicology.

1990-1994, University of Michigan. Course organizer of Intermediate Seminar in Toxicology,

1996 a first-year graduate student presentation seminar course.

1992-1996 University of Michigan. Developed and taught Tissue Culture Methods, a graduate level

course.

1996-2008 University of Michigan. Lecture in Pathologic Basis of Disease on physiology,

pathology and development of the male and female reproductive systems, and on the

physiology and pathophysiology of pregnancy. This is a first-year graduate level course.

1997 University of Michigan. Lectured in Introduction to Research in the Biological Sciences

on reproductive toxicology.

1997-2001 University of Michigan. Lectured in Toxic Exposures at Work and at Home on

reproductive toxicology and endocrine disruption. This was an introductory graduate

course on human diseases caused by environmental and occupational exposures.

2000-2003 University of Michigan. Co-taught Reproductive Epidemiology. This graduate course is

part of the core curriculum for the School of Public Health Interdepartmental

Concentration in Reproductive and Women's Health.

2001 University of Michigan. Lectured in Biochemical and Molecular Toxicology on

alteration of gap junctions as a mechanism of toxicity. This is an advanced graduate

course in the core predoctoral curriculum in toxicology.

2000-2003 University of Michigan. Organized the graduate seminar course Advanced Toxicology

Seminar.

2002 University of Michigan. Lectured in Occupational and Environmental Disease on

reproductive health hazards. This is a first-year graduate course in the core MPH

curriculum of the Department of Environmental Health Sciences.


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2003 University of Michigan. Developed and taught Principles of Environmental Health

Sciences, an introductory course for graduate students in public health who are not

majoring in Environmental Health Sciences.

1994-present University of Michigan. Organizer and main instructor for Mechanisms of Reproductive

Toxicology, an advanced graduate course based on the current scientific literature.

1996-present University of Michigan. Lecture in Principles of Toxicology on various topics,

includingreproductive, developmental and genetic toxicology, and carcinogenesis. This

is the introductory toxicology course in the core predoctoral curriculum in toxicology.

1997-present University of Michigan. Organizer and main instructor for Environmental Chemicals and

Disease, an introductory toxicology course for sophomore and junior undergraduate

students.

2003-present University of Michigan. Lecture in Pathology for Public Health on anatomy, physiology,

pathology and development of the male reproductive system, female reproductive system,

and pregnancy. This is a first-year graduate level course.

DOCTORAL TRAINING PROGRAM AFFILIATIONS

1. NIH #ES07062. Program Director and Training Faculty. "Environmental Toxicology

Pre/Postdoctoral Research Training" (R. Loch-Caruso, Principal Investigator). July 1, 2010 to

June 30, 2015.

2. NIH #GM07767. Training Faculty. "Inter-departmental Training in Pharmacological Science"

(Paul Hollenberg, Principal Investigator). July 1, 2006 to June 30, 2012.

DOCTORAL STUDENT RESEARCH ADVISING

Thesis Chair

1. Robert H. Zidell, Development and Characterization of a Dye-Coupling Assay to Study Gap

Junctional Communication in Smooth Muscle Cells, Ph.D. in Toxicology, 1989. Current position,

Research Scientist, Wyeth-Ayerst Research, Chazy, NY.

2. Daland R. Juberg, A Mechanistic Investigation into o,p'-DDT- and p,p'-DDD-Stimulated

Increases in Rat Uterine Contraction Frequency Ex Vivo, Ph.D. in Toxicology, 1992. Recipient

of the Society of Toxicology Reproductive and Developmental Specialty Section Awards in 1991

and 1992 for posters co-authored with Dr. Loch Caruso. Recipient of the Robert L. Dixon Award

from the Society of Toxicology in 1992 for doctoral thesis research presentation. Current

position, Principal, International Center for Toxicology and Medicine, Rochester, NY.

3. M. Sue (Pahl) Marty, Development of a Rat Myometrial Cell Culture System to Study Hormonal

and Toxicant Effects on Gap Junctional Communication, Ph.D. in Toxicology, 1993. Recipient of

the Honor B. Fell Award from the Tissue Culture Association in 1992 for a poster co-authored

with Dr. Loch Caruso. Current position, Senior Research Toxicologist, Dow Chemical Co.,

Midland, MI.

4. Kay A. Criswell, Assessment of the Elimination of Rat Myometrial Gap Junctional

Communication by the Pesticide Lindane, Ph.D. in Toxicology, 1994. Recipient of the Society of

Toxicology Reproductive and Developmental Specialty Section Award in 1994 for a poster co-

authored with Dr. Loch Caruso. First position following graduation: Associate Director of Drug

Safety Evaluation, Pfizer, Ann Arbor, MI. Current position: Senior Director, Safety Biomarker

Laboratories and Investigative Toxicology, Pfizer Inc., Groton CT.


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5. Jeehyeon Bae, Mechanistic Study of PCB Stimulation of Uterine Contraction, Ph.D. in

Toxicology, 1998. First position following graduation: Postdoctoral trainee, Department of

Gynecology and Obstetrics, Stanford University, CA (with Dr. Aaron Hsueh). Current position;

Professor, College of Medicine Pochon CHA University, Seoul, Korea.

6. Chwen-Ting Wang, Involvement of Phospholipid-Coupled Signaling Pathways in Lindane-

Induced Inhibition of Uterine Contraction, Ph.D. in Toxicology, 1999. Current position, Health,

Environmental & Science Specialist, Dow-Corning Taiwan Inc., Taiwan.

7. Teresa Krieger, D.V.M., Role of Oxidative Stress in Lindane-Induced Inhibition of Myometrial

Function, Ph.D. in Toxicology, 2001. Current position: Research Scientist, Pfizer Inc.

8. Thea Clipson, Mechanisms of Peroxynitrite-Induced Modulation of Contractility in Pregnant

Uterus, Ph.D. in Toxicology, 2002. Recipient of the Society of Toxicology Reproductive and

Developmental Specialty Section Award in 2002 for a poster co-authored with Dr. Loch Caruso.

First position after graduation: Postdoctoral Fellow, Department of Carcinogenesis, The

University of Texas M.D. Anderson Cancer Center, Smithville, TX (with Dr. Cheryl Walker).

Current position: Toxicologist, ToxServices LLC, Washington, D.C.

9. Kelly Brant, Role of Calcium-Independent Phospholipase A2 in PCB-Induced Stimulation of Late

Gestation Rat Uterus and Amnion, Ph.D. in Toxicology, 2005. First position following

graduation: Postdoctoral trainee, University of Pittsburgh. Current position: Research Assistant

Professor, University of Pittsburgh.

10. Daesuk Chung, Mechanisms for the Modification of Rat Uterine Contractions by 2,2'-

Dichlorobiphenyl, Ph.D. in Toxicology, 2005. First position following graduation: Postdoctoral

trainee, University of Colorado (Dr. Barbara Sanborn, mentor). Current position: Research

Fellow, University of Cincinnati.

11. Natalie Thiex, Development of a Gestational Membrane Transwell System for Measurement of

Prostaglandin and Cytokine Responses to Toxciants, Ph.D. in Toxicology, 2008. Current

position: Research Fellow, South Dakota State University (with Dr. Bonny Specker).

12. Mark Miller, The Human Gestational Membranes as a Site of Polybrominated Diphenyl Ether

Toxicity, Ph.D. in Toxicology, 2009. Current position: Senior Assistant Scientist Officer in the

U.S. Public Health Service and Toxicologist at the U.S. EPA, Washington, D.C.

13. Lauren Tetz, Stimulation of Proinflammatory Response by Phthalates in Human Maternal/Fetal

Membranes, Predocotral Candidate in Toxicology.

14. Cassandra Korte, In Vitro Human Gestational Tissue Models for Studying Toxicant Actions

Relevant to Preterm Birth, Predoctoral Candidate in Toxicology.

15. Iman Hassan, Trichloroethylene-Stimulated Inflammation and Oxidative Stress in Gestational

Membranes, Predoctoral Student in Toxicology.

16. Erica Boldenow, Group B Streptococcus Infection of Human Gestational Membranes In Vitro,

Predoctoral Student in Toxicology.

17. Hae-Ryung Park, Brominated Flame Retardant Activation of Parturition, Predoctoral Student in

Toxicology.


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Thesis Co-Chair (*indicates that dissertation research was directed primarily by Dr. Loch-Caruso)

1. John L. Nelson, Partial Purification, Characterization, and Binding Study of a Peroxidase from

Human Placenta, Ph.D. in Toxicology, 1988. Current position, Toxicologist, Ford Motor Co.,

Detroit, MI.

*2. Isabel A. Corcos, Inhibition of Gap Junctional Communication by Antisense DNA and Loss of

Cell Growth Control, Ph.D. in Biology, 1992. Current position, Graduate Student (MPH Program

in Epidemiology), University of California at San Diego (returned to graduate school after

working 13 years in the pharmaceutical industry).

3. Steve Adkins, Cloning and Characterization of the Human Paraoxonase Gene, Ph.D. in

Toxicology, 1993. Current position, Research Fellow, University of Michigan, Ann Arbor, MI.

*4. Mei-Ling Tsai, Modification of Oscillatory Contraction of Rat Uterus by the PCB Congener 4-

Hydroxy-2’4’6’-Trichlorobiphenyl. Ph.D. in Toxicology, 1994. Current position, Professor of

Physiology, National Cheng Kung University, Tainan, Taiwan.

*5. Taeko Tsuneta, Ortho-Substituted Polychlorinated Biphenyl Induced Modulation of Rat Uterine

Muscle Contractions. Ph.D. in Environmental Health, 2005. Current position: Clinical Research

Coordinator, JCD-S Co., Tokyo, Japan.

6. Shannon Yancy, Effects of Sodium Arsenite on Focal Adhesion Organization and Dynamics in

H9C2 Cells. Ph.D. in Toxicology, 2005. Current position: Technology Transfer Associate,

Emory University, Atlanta, GA.

7. Cheryl DeGuzman, HSP27 Phosphorylation and Its Relationship with Microfilaments in Sertoli

Cells. Ph.D. in Toxicology not completed.

8. Chi-Shan Li, Onco-Fetal Antigen P1A in Exocytosis and Tumorigenesis, 2010. Current position:

Postdoctoral Trainee, University of Michigan.

Committee Member (year graduated)

Sumol Pavittranon, Ph.D. in Toxicology (1989)

Ines del C. Figueroa, Ph.D. in Environmental Health (1990)

Jane Wiesen, Ph.D. in Cellular and Molecular Biology (1992)

K. Hew, Ph.D. in Anatomy and Cell Biology (1993)

Pin-Pin Lin, Ph.D. in Toxicology (1994)

Jeffrey Ambroso, Ph.D. in Toxicology (1994)

Joseph Randall, Ph.D. in Toxicology (1994)

R. Hiranruegchok, Ph.D. in Toxicology (1994)

E. Kim, Ph.D. in Toxicology (1996)

J. Vuletich, Ph.D. in Pharmacology (2000)

Scott Billecke, Ph.D. in Pharmacology (2004)

Alexis Handel, Ph.D. in Epidemiology (2005)

Sheela Hasanoge, Ph.D. in Toxicology (2007)

John Phipps, Ph.D. in Toxicology (2009)

Rosaicela Roman Gomez, Ph.D. Candidate in Toxicology (left the program)

David Cantonwine, Ph.D. in Environmental Health Sciences (2009)

Laurie Svoboda, Ph.D. in Toxicology (2010)

Myriam Afeiche, Ph.D. in Environmental Health Sciences (2010)

Paula Johnson, PhD Candidate in Environmental Health Sciences

Edmund O’Brien, PhD Candidate in Toxicology


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MASTERS STUDENT RESEARCH ADVISING

Thesis Advisor

1. Madeline Cimini, Standardization and Development of the Scrape-Loading Assay, an In Vitro

Method to Study Gap Junction Mediated Cell-to-Cell Communication, M.S. in Toxicology, 1987.

2. Sonia Schmerl, An Assay for the Inhibition of Intercellular Dye Transfer in Hydra Attenuata,

M.S. in Toxicology, 1988.

3. Cathy Cull, Effects of Nickel, Mercury, and Arsenic on Gap Junctional Communication in The

Uterine Cell Line, SK-UT-1, M.S. in Toxicology and Industrial Health, 1989.

4. Kay Criswell, Effects of Hexachlorocyclohexane on Rat Myometrial Smooth Muscle, M.S. in

Toxicology, 1992.

5. Paul Wilga, Connexin43 Phosphorylation and its Potential Role in the Inhibition of Gap

Junctional Communication in Rat Myometrial Cells, M.S. in Toxicology, 1993.

6. Vincent Peterkin, Tetrachloroethane Effects on Rat Uterine Smooth Muscle, M.S. in Toxicology,

1994.

7. Rebecca Kushner, Role of Arachidonic Acid Metabolism in Lindane-Inhibition of Myometrial

Gap Junctions, M.S. in Toxicology, 1996.

6. Thea Clipson, Sodium Channel Activation and DDT Stimulation of Uterine Contraction, M.S. in

Toxicology, 1996.

7. Jennifer Magun, Cadmium Cardiotoxicity. M.S. in Toxicology, 2001.

8. Yunseon Chung, Estimation of DNA Damage and Telomerase Activity Induced by Arsenic (III)

on Primary Cultured Human Skin Cells, M.S. in Toxicology, 2002.

9. Fuyuan Wang, Effects of PCB 153 on Rat Uterine Contractility and Responsiveness to Oxytocin

and Prostaglandin F2α using an In Vivo Exposure/Iin Vitro Analysis Model, M.S. in Toxicology,

2009.

10. Rebecca Adams, Mono-2-Ethylhexyl Phthalate Stimulates Cell Death in the Human Trophoblast

Cell Line, HTR-8/SVneo. M.S. in Toxicology, 2009.

Research Mentor

Virgil Caldwell, Kepone Inhibition of Gap Junctional Communication in a Human Embryonal

Cell Line, M.S. in Chemistry, Eastern Michigan University, 1991.

POSTDOCTORAL RESEARCH TRAINING

1. Saryu Goel, D.V.M., Ph.D. (1997-2000). Current position, Research Scientist, Amgen.

2. Kimberly Cesen Cummings, Ph.D. (1997-98). First position after completing training:

postdoctoral trainee, NIEHS, NIH (with Dr. Barbara Davis). Current position, Regulatory Scientist, Cato Research Ltd., Durham, NC.

3. Patricia Kimani, Ph.D. (2009 – present). Current trainee.

UNDERGRADUATE STUDENT RESEARCH ADVISING

1. Mona Hanna, Honors Thesis, School of Natural Resources & the Environment, 1998.

2. D. Reddy, Honors Thesis in Molecular, Cellular, and Developmental Biology, 2004-05.


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3. David Simon, Internship and Specialization Advisor, Program in the Environment, 2004.

4. Amy Burgin, Specialization Advisor, Program in the Environment, 2004-05.

5. Anne St. Louis, Specialization Advisor, Program in the Environment, 2004-05.

6. Adva Gadoth, Internship Advisor and Research Supervisor, 2008-2010.

7. Adrienne Cheng, Honors Thesis Mentor, Program in the Environment, 2010-1011.

PROFESSIONAL ACTIVITIES

Membership in Professional Associations

1. Michigan Regional Chapter of the Society of Toxicology: Full member since 1982.

2. Tissue Culture Association: Full member 1985-95.

3. Teratology Society: Full member 1985-95.

4. Society of Toxicology: Full member since 1990.

5. Society for the Study of Reproduction: Regular member since 1992.

6. American Society of Cell Biology: Regular member since 1992.

7. American Association for the Advancement of Science. Regular member.

8. Society for the Gynecologic Investigation: Regular member since 2007.

Community-Based Public Health Activities

1. Allen’s Creek Watershed Group (Ann Arbor, MI): Charter member (1997) and co-author of the

Allen’s Creek Watershed Management Plan.

Government Service

1. City of Ann Arbor, MI: Member, Environment Commission (2000- ); Chair, Environment

Commission (2003-06); Chair, Environment Commission Water Subcommittee (2000-04);

Member, Environment Commission Water Committee (2000- ); Assisted in grant application

preparation to the EPA Community Action for a Renewed Environment (CARE) program (2006);

Member, Stormwater Citizen Advisory Task Force member (2006-2007).

2. Washtenaw County, MI: Charter Member, Coalition for Action on the Remediation of Dioxane

(CARD) (2006- ).

Service to National and State Grant Agencies

1. NIH: Ad Hoc Reviewer, Toxicology II Study Section (June 1994, February 1995); Ad Hoc

Reviewer, Clinical Sciences Special Emphasis Panel (February 24, 1995); Member, Toxicology II

Study Section (1995); Member, Alcohol and Toxicology II Study Section (1995-97); Member,

NIEHS Environmental Health Sciences Review Committee (2001-03); Member, NIEHS

Superfund Basic Research Program Review Committee (2004); Member, NCRR Research

Centers in Minority Institutions (RCMI)/Centers of Biomedical Research Excellence (COBRE)

Review Panel (2009).

2. Michigan Great Lakes Protection Fund: Grant Reviewer (1998); Member, Technical Advisory

Board (1999-2002), Chair (2001-02).

3. March of Dimes Birth Defects Foundation: Ad-hoc Grant Reviewer (1988).


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Service to National and State Professional Organizations

1. Michigan Regional Chapter of the Society of Toxicology: Member, Nominating Committee

(1987-88); Member, Fall Meeting Planning Committee (1992); Member, Nominating Committee

(1991-92); President-Elect (1994-95); President (1995-96); Councilor (1996-97); Newsletter

Editor (1996-98); Councilor (2011-12).

2. Society of Toxicology (SOT) Reproductive and Developmental Toxicology Specialty Section: Member, Nominating Committee, Chair (1992-93); Councilor (1994-97); Vice-President Elect

(1998-99); Vice-President (1999-2000); President (2000-01).

3. Society of Toxicology (SOT): Member, Undergraduate Education Subcommittee of the SOT

Education Committee (2010-present).

4. Society for the Study of Reproduction: Member, Meeting Facilities Committee (1993-94);

Member, Education Committee (1995-96); Member, By-Laws Committee (2000-01); Member,

Reproduction and the Environment Committee (2006-present); Member, Program Committee

(2011-2012).

5. Tissue Culture Association: Member, Scientific Meetings Committee (1991-92); Member,

Program Committee (1992-93); Member, Laboratory Materials and Biosafety Committee (1992-

93); Member, Audio-Visual Committee, Chair (1992-94).

6. US EPA: Promotion evaluation of staff scientists (1996, 2000).

7. Institute of Medicine, National Academies of Science: Member, Committee on Understanding

Premature Births and Assuring Healthy Outcomes (2005-2006).

Service Organizing National and International Meetings

1. The 1991 World Congress on Cell and Tissue Culture: Organizer and co-convener of session-in-

depth on Intercellular Communication and Tissue Function (Anaheim, CA, June 16-20, 1991)

2. Annual Meeting of the Tissue Culture Association: Organizer and convener of session-in-depth

on "Role of Cell Membrane in Cell and Tissue Injury" (San Diego, CA, June 5-9, 1993).

3. NIEHS Symposium on Epigenetic Toxicant-Induced Signal Transduction and Altered Cell-Cell

Communication: Organizing Committee (Ann Arbor, MI, October 17-20, 1999).

4. NIEHS PCB Workshop: External Advisory Committee (Lexington, KY, April 9-12, 2000).

5. Institute of Medicine/March of Dimes Workshop on Environmental Causes of Prematurity:

Organizing Committee (Washington, D.C., October 2-3, 2001)

Service to Peer- Reviewed Journals

1. Ad Hoc Journal Reviewer: Teratology, Cell Biology and Toxicology, Fundamental and Applied

Toxicology, Toxicology and Applied Pharmacology, Biochemical Pharmacology, American

Journal of Physiology, Life Sciences, and In Vitro Toxicology, Environmental Health

Perspectives.

2. Editorial Board: Biology of Reproduction (2000-04).

Service Activities at the University of Michigan

University

1. Office of the Provost and Vice President for Academic Affairs: Ad Hoc Proposal

Reviewer (1992).


12

2. Office of the Vice President for Research: Ad Hoc Proposal Reviewer (1987); Member,

Women's Health Initiative Forum Planning Committee (1992); Member, Task Force on the

Reporting Relationship of the Reproductive Sciences Program (1998-99).

3. University of Michigan SACUA: Member, Faculty Senate Academic Affairs Committee

(1992-94).

4. Horace H. Rackham School of Graduate Studies: Member, Faculty Selection Committee

for the Rackham Dissertation/Thesis Grant (1986); Member, Biological Science Division

Review Board (1992-94); Member, Rackham Postdoctoral Issues Discussion Group (2007),

Member, Executive Board (elected) (2010-2013).

5. Biomedical Research Council: Ad Hoc Proposal Reviewer (1990).

6. Women in Science Program: Mentor, Undergraduate Research Internship (1989-91); Panel

Participant "Moms in Science and Engineering" (1994).

7. Undergraduate Research Opportunities Program: Mentor (1991-92, 2000-01).

Interdepartmental Graduate Training Programs

1. Reproductive Sciences Program: Trainee Selection Committee (1989-91; 2000-03; 2005-

2007); Program Committee (1992-93); Organizer and Co-chair of Workshop on Reproductive

and Developmental Toxicology (1994); Training Committee (1995-96); Internal Review

Training Subcommittee (1996-97); Executive Committee (1996-99; 2010- present).

2. Environmental Toxicology Research Training Program: Toxicology Training Grant

Committee (1986-95; 2003-2010); Program Director (1999-2003); Chair, Steering Committee

(1999-2003); Associate Director (2003-2008).

3. Pharmacological Sciences and Biorelated Chemistry Training Program: Member,

Biology Track Subcommittee (2001-present); Member, Parent Program Committee (2001-

present).

4. Environmental Toxicology and Epidemiology Program: Director (2010 – present).

School of Public Health

1. Task Force on Racial and Cultural Concerns, member (1990-91, 1992-94) and Co-Chair

(1991-92).

2. Affirmative Action Committee (1994; 2005-2011).

3. Human Subjects Review Committee (1993-94).

4. SPH Executive Committee (1995-99).

5. Interdepartmental Concentration in Reproductive and Women’s Health Executive Committee

(1998-2008).

6. Michigan Bridges to the Doctorate Program: Admissions and Advisory Committee (2003-

present)

Department of Environmental Health Sciences

1. Executive Committee (1987-94; 2002-2004; 2005-08).

2. Safety Committee (1987-91),

3. Toxicology Rackham Block Grant Committee, Chair (1987-88 and 1990-93).

4. Faculty Search Committee for Toxicology (1988-89).


13

5. Faculty Search Committee for Occupational Health (1988-89).

6. Admissions Committee (1990-94 and 1997-98).

7. Faculty Search Committee for Radiological Health (1993-94).

8. Faculty Search Committee for Toxicology (1996-97).

9. MPH Curriculum Subcommittee, Chair (1997-99).

10. Curriculum Committee (1998-2001).

11. Toxicology Program Director (1999-2003).

12. Faculty Search Committee (2000; 2007-2008).

13. Recruitment Committee (2002-2004).

14. Toxicology Symposium Program Committee (2002-04).

15. Faculty Retreat Planning Committee (2003).

16. Toxicology Qualifying Examination Committee, Chair (1987-90, 1996-97) and member

(1986, 1992-94; 2003-04; 2004-05).

17. Student Affairs Committee, Chair (2004-05).

18. Admissions & Recruitment Committee, Chair (2005-07).

19. Department Coordinator, National Research Council Graduate Program Review, 2006-07.

20. Department Coordinator, Rackham Graduate Program Review, 2006-07.

21. UM SPH EHS Alums Group, Faculty representative, 2007-2008.

22. Academic Degrees Program Committee (2010-2011).

23. Toxicology Program Leader (2010-present).

Program in the Environment

1. Graduate Student Instructor Selection Committee (2006-07).

2. Instructor Review Committee (2009-2010).

3. Faculty Advisory Committee (2007 – present).

College of Literature, Science, and the Arts

1. Tenure Review Panel member (2011-2012).

Service to Non-Profit Organizations

1. Southeast Michigan Coalition on Occupational Safety and Health: Scientific consultant (Pro

Bono, 1987-88).

2. Extension Toxicology Network: Scientific consultant (Pro Bono, 1995).

3. Michigan Environmental Council/Ecology Center: Member, Science Advisory Committee

(Pro Bono, 2001-03).

4. Neighborhoods Adversely Impacted by Dioxane (citizen group): Consultant (Pro Bono,

2003-04)


14

Consulting

1. National Sanitation Foundation, Ann Arbor, MI, 1989-90.

PUBLICATIONS * *Asterisks denote publications for which Dr. Loch-Caruso is the principal author who directed the study. On publications with her trainees, the trainee is usually listed as first author.

Peer-Reviewed Research Articles

1. Michaelson, I.A., Rafales, L.S., Bornschein, R.L. and Loch, R.K. Lead and hyperactivity in animals. Psychopharmacol. Bull. 14:48-50, 1978.

*2. Loch, R.K., Rafales, L.S., Michaelson, I.A. and Bornschein, R.L. The role of undernutrition in animal models of hyperactivity. Life Sci. 22:1963-1970, 1978.

3. Rafales, L.S., Bornschein, R.L., Michaelson, I.A., Loch, R.K. and Barker, G.F. Drug- induced activity in lead-exposed mice. Pharmacol. Biochem. Behav. 10:1-10, 1979.

*4. Loch-Caruso, R. and Baxter, C.S. DNA damage and repair in mouse embryonic hindlimbs exposed to teratogenic doses of methylnitrosourea. Mutat. Res. 131:147-155, 1984.

5. Depak, D.K., Loch-Caruso, R., Trosko, J.E., Chakravarty, I., Ghosh, A. and Loeb, L.A. Assessment of the carcinogenic potential of a proposed food coloring additive, laccaic acid, using short-term assays. Cell Biol. Toxicol. 1:111-125, 1984.

*6. Loch-Caruso, R., Trosko, J.E. and Corcos, I.A. Interruption of cell-cell communication in Chinese hamster V79 cells by various glycol ethers: Implications for teratogenicity. Environ. Health Perspect. 57:119-123, 1984.

*7. Loch-Caruso, R. and Baxter, C.S. DNA strand breaks in embryonic mouse limbs exposed to methylnitrosourea. Drug Chem. Toxicol. 11:275-287, 1988.

*8. Bevilacqua, A., Loch-Caruso, R. and Erickson, R.P. Abnormal dye coupling and devel-opment in preimplantation mouse embryos produced by antisense RNA to gap junction protein. Proc. Natl. Acad. Sci. USA, 86:5444-5448, 1989.

*9. Loch-Caruso, R., Caldwell, V., Cimini, M. and Juberg, D. Comparison of assays for gap junctional communication using human embryocarcinoma cells exposed to dieldrin. Fundam. Appl. Toxicol. 15:63-74, 1990.

*10. Zidell, R. and Loch-Caruso, R. A simple dye-coupling assay for evaluating gap junctional communication: The importance of transcription and translation on the establishment of dye-coupling. Cell Biol. Int. Rep. 14:613-628, 1990.

*11. Loch-Caruso, R., Juberg, D.R., Caldwell, V. and Corcos, I.A. Cultured myometrial cells establish communicating gap junctions. Cell Biol. Int. Rep. 14:905-916, 1990.

*12. Loch-Caruso, R., Corcos, I.A. and Trosko, J.E. Inhibition of metabolic coupling by metals. J. Toxicol. Env. Health 32:33-48, 1991.

*13. Juberg, D.R. and Loch-Caruso, R. Increased contraction frequency in rat uterine strips treated in vitro with o,p'-DDT. Bull. Environ. Contam. Toxicol. 46:751-755, 1991.

*14. Juberg, D.R., Webb, R.C. and Loch-Caruso, R. Characterization of o,p'-DDT-stimulated contraction frequency in rat uterus in vitro. Fundam. Appl. Toxicol. 17:543-549, 1991.

*15. Loch-Caruso, R., Pahl, M.S. and Juberg, D.R. Rat myometrial smooth muscle cells show high levels of gap junctional communication under a variety of culture conditions. In Vitro Cell. Dev. Biol. 28A:97-101, 1992.


15

*16. Corcos, I.A., Lafreniere, R.G., Begy, C.R., Loch-Caruso, R., Willard, H.F. and Glover, T.W. Refined localization of human connexin32 gene locus, GJB1, to Xq13.1. Genomics 13:479-480, 1992.

*17. Juberg, D.R. and Loch-Caruso, R. Investigation of the role of estrogenic action and prostaglandin E2 in DDT-stimulated rat uterine contractions ex vivo. Toxicology 74:161- 172, 1992.

*18. Caldwell, V. and Loch-Caruso, R. Chlordecone rapidly and reversibly inhibits gap junctional communication in human embryonic palatal mesenchyme cells. In Vitro Toxicol. 5:113-122, 1992.

*19. Corcos, I.A., Meese, E.U. and Loch-Caruso, R. Human connexin43 gene locus, GJA1, sublocalized to 6q21-23.2. Cytogenet. Cell Genet. 64:31-32, 1993.

*20. Marty, M.S. and Loch-Caruso, R. Improved gap junctional communication in cultured uterine cells treated with nickel (II) chloride. In Vitro Cell. Dev. Biol. 29A(Part I):215-220, 1993.

*21. Criswell, K.A., Stuenkel, E.L. and Loch-Caruso, R. Lindane increases intracellular calcium in rat myometrial smooth muscle cells through modulation of inositol 1,4,5-trisphosphate-sensitive stores. J. Pharmacol. Exper. Ther. 270:1015-1024, 1994.

*22. Watts, S.W., Tsai, M.-L., Loch-Caruso, R. and Webb, R.C. Gap junctional communication and vascular smooth muscle reactivity: use of tetraethylammonium chloride. J. Vasc. Res. 31:307-313, 1994.

23. Kamrin, M.A, Carney, E.W., Chou, K., Cummings, A., Dostal, L.A., Harris, C., Henck, J.W., Loch-Caruso, R. and Miller, R.K. Female reproductive and developmental toxicology: overview and current approaches. Toxicol. Lett. 74:99-119, 1994.

*24. Criswell, K.A., Loch-Caruso, R. and Stuenkel, E.L. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messengers. Toxicol. Appl. Pharmacol. 130:280-293, 1995.

*25. Criswell, K.A. and Loch-Caruso, R. Lindane-induced elimination of gap junctional communication in rat myometrial myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol. Appl. Pharmacol. 135:127-138, 1995.

*26. Juberg, D.R., Stuenkel, E.L. and Loch-Caruso, R. The chlorinated insecticide 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDD) increases intracellular calcium in rat myometrial smooth muscle cells. Toxicol. Appl. Pharmacol. 135:147-155, 1995.

*27. Tsai, M.-L., Watts, S.W., Loch-Caruso, R. and Webb, R.C. Role of gap junctional communication in contractile oscillations in arteries from normotensive and hypertensive rats. J. Hypertension 13:1123-1133, 1995.

*28. Tsai, M.-L., Webb, R.C. and Loch-Caruso, R. Congener-specific effects of PCBs on contractions of pregnant rat uteri. Reprod. Toxicol. 10:21-28, 1996.

*29. Tsai, M.-L., Webb, R.C. and Loch-Caruso, R. The increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2’,4’,6’-trichlorobiphenyl is estrogen receptor-mediated. Biol. Reprod. 56:341-347, 1997.

*30. Marty, M.S. and Loch-Caruso, R. 2-Methoxyethanol inhibits gap junctional communication in rat myometrial myocytes. J. Cell Biol. Toxicol. 14:199-210, 1998.

*31. Tsai, M.-L., Cesen-Cummings, K., Webb, R. C., and Loch-Caruso, R. Acute inhibition of spontaneous uterine contractions by an estrogenic polychlorinated biphenyl is associated with the disruption of gap junctional communication. Toxicol. Appl. Pharmacol. 152:18-29, 1998.


16

*32. Bae, J., Stuenkel, E., and Loch-Caruso, R. Stimulation of pregnant rat uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca

2+]i through voltage-operated

calcium channels. Toxicol. Appl. Pharmacol. 155:261-272, 1999.

*33. Bae, J., Peters-Golden, M., and Loch-Caruso, R. Stimulation of pregnant rat uterine contraction by the PCB mixture Aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. J. Pharmacol. Exper. Ther. 289:1112-1120, 1999.

*34. Criswell, K.A. and Loch-Caruso, R. Lindane-induced inhibition of spontaneous contractions of pregnant rat uterus. Reprod. Toxicol. 13:481-490, 1999.

35. Loch-Caruso, R. A mechanistic-based approach for assessing chemical hazards to parturition. J. Wom. Health, 8:235-247, 1999.

*36. Bae, J., Mousa, M.A., Quensen, J.F., III, Boyd, S.A., and Loch-Caruso, R. In vitro stimulation of contraction of pregnant rat uterus by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Environ. Health Perspec. 109:275-282, 2001.

*37. Krieger, T.R. and Loch-Caruso, R. Role of oxidative stress in lindane's inhibition of rat myometrial function. Biol. Reprod. 64:537-547, 2001.

*38. Wang, C.-T., Peters-Golden, M., and Loch-Caruso, R. A calcium-independent phospholipase

activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat

myometrial cells. Life Sci. 70:453-470, 2001.

*39. Wang, C.-T. and Loch-Caruso, R. Phospholipase-mediated inhibition of spontaneous

oscillatory uterine contractions by lindane in vitro. Toxicol. Appl. Pharmacol. 182:136-147,

2002.

40. Loch-Caruso, R. Uterine Muscle as a Potential Target of Polychlorinated Biphenyls during

Pregnancy. Int. J. Hyg. Environ. Health, 205:121-130, 2002.

41. Loch-Caruso, R.K., Criswell, K.A., Grindatti, C.M. and Brant, K.A. Sustained inhibition of

rat myometrial gap junctions and contractions by lindane. Reprod. Biol. Endocrinol., 1:62,

2003 (public access peer-reviewed electronic journal).

42. Loch-Caruso, R., Galvez, M.M., Brant, K. and Chung, D. Cell and toxicant specific

phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344

liver cell gap junctions. Cell Biol. Toxicol. 20:147-169, 2004.

43. Loch-Caruso, R., Upham, B.L., Harris, C. and Trosko, J.E. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol. Sci. 85: 694-702, 2005.

44. Loch-Caruso, R., Upham, B.L., Harris, C. and Trosko, J.E. Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells. Toxicol. Sci., 86: 417-426, 2005.

*45. Chung, D. and Caruso, R. Loch. 2,2-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions. Biol. Reprod. 73: 974-982, 2005.

*46. Brant, K. and Caruso, R. Loch. Late gestation rat myometrial cells express multiple isoforms of phospholipase A2 that mediate PCB 50-induced release of arachidonic acid with coincident prostaglandin production. Toxicol. Sci. 88: 222-230, 2005.


17

*47. Brant, K., Guan, W., Tithof, T. and Caruso, R. Loch. Gestation age-related increase in 50 kDa rat uterine calcium-independent phospholipase A2 expression influences uterine sensitivity to polychlorinated biphenyl stimulation. Biol. Reprod. 74: 874-880, 2006.

*48. Chung, D. and Caruso, R. Loch. 2,2-Dichlorobiphenyl-induced inhibition of myometrial gap junction communication is independent of oxidative stress. Toxicol. Sci. 93(1): 172-179, 2006.

*49. Brant, K. and Caruso, R. Loch. PCB 50 stimulates release of arachidonic acid and prostaglandins from late gestation rat amnion fibroblast cells. Reprod. Toxicol. 22(4): 591-8, 2006. Epub 2006 May 19.

*50. Li, C.-S. and Loch-Caruso, R. Sodium arsenite inhibits migration of extravillous trophoblast cells in vitro. Reprod. Toxicol. 24(3): 296-302, 2007. http://dx.doi.org/10.1016/j.reprotox.2007.06.002

*51. Tsuneta, T., Hanna-Attisha, M., Grindatti, C., Quensen, J.F. III, Boyd, S.A. and Caruso, R. Loch. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction. Environ. Res. 107(2):185-93, 2008. Epub 2008 Mar 21. PMCID: PMC2699757

*52. Miller, M.F., Chernyak, S.M., Batterman, S. and Loch-Caruso, R. Polybrominated diphenyl ethers in human gestational membranes from women in Southeast Michigan (USA). Environ. Sci. Technol., 43 (9):3042–3046, 2009. (online April 6, 2009). PMCID: PMC2700303

*53. Meeker, J.D., Hu,H., Cantonwine, D.E., Lamadrid-Figueroa, H., Calafat, A.M., Ettinger, A.S., Hernandez-Avila, M., Loch-Caruso, R., María Téllez-Rojo, M. Urinary phthalate metabolites in relation to preterm birth in Mexico City. Environ. Health Perspect. 117:1587–1592, 2009. PMCID: PMC2790514

*45. Thiex, N.W., Chames, M.C., Loch-Caruso, R. Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system. Reprod. Biol. Endocrinol. 7:117, 2009. PMCID: PMC2774314

*46. Miller, M.F. and Loch-Caruso, R. Comparison of LPS-stimulated release of cytokines in

punch versus transwell tissue culture systems of human gestational membranes. Reprod. Biol.

Endocrinol. 8:121, 2010. PMCID: PMC2965156

*47. Thiex, N.W., Chames, M.C. and Loch-Caruso, R. Tissue-specific induction of COX-2 and

prostaglandins in lipopolysaccharide-stimulated extraplacental human gestational membranes

in a 2-chamber transwell culture system. Reprod. Sci. 17(12):1120-1129, 2010.

doi:10.1177/1933719110378344. PMCID: PMC3096444

48. Ferguson, K.K., Loch-Caruso, R. and Meeker, J.D. Urinary phthalate metabolites in relation

to measures of inflammation and oxidative stress: NHANES 1999-2006. Environ. Res.

111(5):718-26, 2011. Epub 2011 Feb 23. PMCID: PMC3110976.

49. Ferguson, K.K., Loch-Caruso, R. and Meeker, J.D. Exploration of oxidative stress and

inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006.

Environ. Sci. Technol. 111: 718-26, 2012. Epub Nov 15, 2011. DOI: 10.1021/es202340b.

*50. Miller, M.F., Chernyak, S.M., Batterman, S. and Loch-Caruso, R. Concentrations and speciation of polybrominated diphenyl ethers (PBDEs) in human amniotic fluid. Sci. Total Environ., in press. DOI: 10.1016/j.scitotenv.2011.11.088. NIHMSID: 345116.

51. Mao, X., Ciblak, A., Baek, K., Amiri, M., Loch-Caruso, R., and Alshawabkeh, A.N. Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes. Water Res. 2012 Jan 8. [Epub ahead of print]

http://dx.doi.org/10.1016/j.reprotox.2007.06.002

http://www.pubmedcentral.gov/articlerender.fcgi?tool=nihms&artid=3096444


18

In Preparation

*52. Kamau, P.W., Tetz, L., Cheng, A., and Loch-Caruso, R. Artifacts using the 2′,7′-dichlorodihydrofluorescein diacetate assay to measure toxicant-stimulated cellular production of reactive oxidant species. In preparation.

*53. Boldenow, E., Jones, S., Xi, C., and Loch-Caruso, R. Amniotic HBD-2 expression and decreased Group B Streptococcus viability in tissue cultures of intact human extraplacental membranesAmniotic HBD-2 expression and decreased Group B Streptococcus viability in tissue cultures of intact human extraplacental membranes. In preparation.

Book Chapters

*52. Michaelson, I.A., Bornschein, R.L., Loch, R.K. and Rafales, L.S. Minimal brain dysfunction hyperkinesis: Significance of nutritional status in animal models of hyperactivity. In Animal Models in Psychiatry and Neurology, I. Hanin and E. Usdin, eds., New York, Pergamon Press, 1977, pp. 37-49.

*53. Bornschein, R.L., Michaelson, I.A., Fox, D.A. and Loch, R.K. Evaluation of animal models used to study effects of lead on neurochemistry and behavior. In Biochemical Effects of Environmental Pollutants, S.D. Lee, ed., Ann Arbor, MI, Ann Arbor Science Publishers, 1977, pp. 441-460.

*54. Loch-Caruso, R. Alteration of gap junctions as a potential mechanism of reproductive toxicity. In Biochemical Mechanisms and Regulation of Intercellular Communication, H.A. Milman and E. Elmore, eds., Princeton Scientific Publishing, Princeton, NJ, 1987, pp. 137-149.

*55. Loch-Caruso, R. Application of cell-cell communication assays to problems of develop-mental toxicology. In In Vitro Techniques in Developmental Toxicology: Use in Defining Mechanisms and Risk Parameters, G.L. Kimmel and D.M. Kochhar, eds., CRC Press, Boca Raton, FL, 1990, pp. 45-67.

*56. Loch-Caruso, R. and Krieger, T.R. Parturition. In Comprehensive Toxicology, Vol. 10, Reproductive and Endocrine Toxicology, K. Boekelheide, R. Chapin, P. Hoyer, and C. Harris, eds., Pergamon, New York, 1997, pp. 471-478.

Other Publications

*57. Loch-Caruso, R. Comparison of assays for gap junctional communication using human embryocarcinoma cells exposed to dieldrin (Response to Letter-to-the-Editor). Fundam. Appl. Toxicol. 16:842-844, 1991.

*58. Committee on Understanding Premature Births and Assuring Healthy Outcomes. Preterm Birth: Causes, Consequences, and Prevention, R.E. Behrman and A. Stith Butler, Eds. The National Academies Press, Washington, DC, 2006.

PUBLISHED ABSTRACTS

1. Loch, R.K., Bornschein, R.L. and Michaelson, I.A. Role of undernutrition in the paradoxical

response of lead (Pb) exposed "hyperactive" mice to amphetamine (AMP) and phenobarbital

(PB). Pharmacologist 18, 1976.

2. Loch, R.K. and Baxter, C.S. Teratogenesis and DNA damage in mouse embryonic hindlimbs

exposed in utero to methylnitrosourea. Teratology 25:59A, 1982.

3. Loch-Caruso, R., Corcos, I.A. and Trosko, J.E. Inhibition of metabolic cooperation by

metals. Toxicologist 6:267, 1986.


19

4. Loch-Caruso, R., Corcos, I.A. and Trosko, J.E. Acetic acid derivatives of 2-methoxyethanol

and 2-ethoxyethanol fail to inhibit metabolic cooperation. In Vitro Cell. Dev. Biol. 22(Part

II):45A, 1986.

5. Loch-Caruso, R., Cimini, M.G., Juberg, D., Corcos, I.A. and Caldwell, V. Comparison of

assays for inhibition of gap junctional communication in human teratocarcinoma (HT) cells.

Teratology 37:475, 1988.

6. Juberg, R.D., Caldwell, V.D., Pahl, M.S. and Loch-Caruso, R. Gap junction-mediated

intercellular communication in cultured rat myometrial cells. In Vitro Cell. Dev. Biol. 26(Part

II):63A, 1990.

7. Loch-Caruso, R. and Caldwell, V.D. Inhibition of gap junction-mediated intercellular

communication in human embryonic palatal mesenchyme cells. In Vitro Cell. Dev. Biol.

26(Part II):63A, 1990.

8. Juberg, D.R. and Loch-Caruso, R. o,p'-DDT increases contraction frequency of rat uterine

strips in vitro. Toxicologist 11:70, 1991.

9. Pahl, M.S. and Loch-Caruso, R. Increased gap junction-mediated intercellular commu-

nication in SK-UT-1 cells exposed to nickel (II) chloride in vitro. Toxicologist 11:274, 1991.

10. Loch-Caruso, R. and Pahl, M.S. Chemical modulation of gap junctional communication in

myometrial cultures. In Vitro Cell. Dev. Biol. 27(Part II):58A, 1991.

11. Corcos, I., Loch-Caruso, R. and Tsubota, S.I. Antisense-inhibited gap junctional

communication: Direct selection of non-communicating cells. In Vitro Cell. Dev. Biol. 27(Part

II):50A, 1991.

12. Loch-Caruso, R. Elevated temperature inhibits dye coupling in hydra transplants. In Vitro

Cell. Dev. Biol. 27(Part II):166A, 1991.

13. Tsai, M.-L., Corcos, I.A., Juberg, D., Loch Caruso, R. and Webb, R.C. Messenger RNA for

gap junction protein and oscillatory contractions in mesenteric arteries from genetically

hypertensive rats. Hypertension 18:392, 1991.

14. Pahl, M.S. and Loch-Caruso, R. 2-Methoxyethanol effects on rat uterine cell and tissue

function. Toxicologist 12:432, 1992.

15. Juberg, D.R., Stuenkel, E.L. and Loch-Caruso, R. The effect of p,p'-DDD on intracellular

calcium in rat myometrial cells. Toxicologist 12:127, 1992.

16. Tsai, M.-L., Loch-Caruso, R. and Webb, R.C. Characteristics of intercellular communication

in mesenteric vascular smooth muscle cells from rats. FASEB J 6:8970, 1992.

17. Marty, M.S. and Loch-Caruso, R. Steroid-responsive rat primary myometrial cell cultures for

the study of gap junctions. In Vitro Cell. Dev. Biol. 28(Part II):159A, 1992.

18. Criswell, K., Loch-Caruso, R. and Stuenkel, E. Lindane inhibits gap junctional

communication (GJC) in rat myometrial cells via a calcium-independent process. Toxicologist

13: 354, 1993.

19. Marty, M.S. and Loch-Caruso, R. Altered gap junctional communication and membrane

fluidity in rat myometrial cells treated with 2-methoxyethanol. In Vitro Cell. Dev. Biol.

29A(Part II):44A, 1993.

20. Criswell, K.A. and Loch-Caruso, R. Lindane increases cAMP and inhibits spontaneous rat

uterine contractions. Toxicologist 14:80, 1994.


20

21. Tsai, M.-L. and Loch-Caruso, R. The influence of PCB congeners on myometrial

contractions from midgestation rats. Toxicologist 14:80, 1994.

22. Tsai, M.-.L and Loch-Caruso, R. Effects of 4-hydroxy-2',4',6'-chlorobiphenyl (4OH246TCB)

and 17-estradiol on agonist-induced oscillatory contractions of pregnant uteri. Biol. Reprod.

50(Supp. 1):76, 1994.

23. Marty, M.S. and Loch-Caruso, R. The effects of arachidonic acid and some of its metabolites

on gap junctional communication in rat myometrial cell cultures. Biol. Reprod. 50(Supp.

1):60, 1994.

24. Peterkin, V. and Loch-Caruso, R. 1,1,2,2-Tetrachloroethane inhibits oscillatory contraction

in isolated mid-gestation rat uteri. Biol. Reprod. 50(Supp. 1):76, 1994.

25. Criswell, K.A. and Loch-Caruso, R. Lindane-induced elimination of gap junctional

communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-

independent mechanism. Biol. Reprod. 50(Supp. 1):100, 1994.

26. Watts, S.W., Tsai, M.-L., Loch-Caruso, R. and Webb, R.C. Gap junctions mediate agonist-

induced oscillatory contractions in vascular smooth muscle. J. Vasc. Res. 31:305, 1994.

27. Tsai, M.-L., Webb, R.C. and Loch-Caruso, R. Acute inhibition of uterine contraction by 4-

hydroxy-2’,4’,6’-trichlorobiphenyl (4OHTCB) may result from disruption of gap junctional

communication. Toxicologist 15:275, 1995.

28. Criswell, K.A. and Loch-Caruso, R. Lindane has a delayed inhibitory effect on spontaneous

rat uterine contractions and myometrial cell-cell communication. Toxicologist 15:275, 1995.

29. Tsai, M.-L., Webb, R.C. and Loch-Caruso, R. Inhibition of spontaneous oscillatory uterine

contractions by 17-estradiol is associated with disruption of gap junctional communication.

Biol. Reprod. 52(Supp. 1):115, 1995.

30. Bae, J.H. and Loch-Caruso, R. The polychlorinated biphenyl (PCB) mixtures Aroclor 1242

(A1242), Aroclor 1248 (A1248) and Aroclor 1254 (A1254) stimulate contractions of day 10

pregnant rat uteri. Fundam. Appl. Toxicol. 30(Supp):322, 1996.

31. Krieger, T., Loch-Caruso, R., Upham, B. and Trosko, T.E. Glutathione modulation affects

lindane-induced inhibition of gap junctional intercellular communication between rat

myometrial cells. Biol. Reprod. 54(Supp):179, 1996.

32. Loch-Caruso, R. and Tsai, M.-L. Possible involvement of gap junctions in the development

of spontaneous oscillatory contractions in uteri. Biol. Reprod. 54(Supp):118, 1996.

33. Bae, J. and Loch-Caruso, R. Stimulation of rat uterine oscillatory contraction by a

polychlorinated biphenyl mixture, Aroclor 1242, and its sustained effect after removal of the

compound. Biol. Reprod. 54(Supp):182, 1996.

34. Galvez, M.M. and Loch-Caruso, R. Lindane inhibits gap junctional communication in

myometrial cells without changing the abundance or phosphorylation of connexin43 (Cx43)

protein. Fundam. Appl. Toxicol. 36(Supp):57, 1997.

35. Bae, J. and Loch-Caruso, R. The PCB mixture Aroclor 1242 (A1242) inhibits gap junctional

intercellular communication in a transient manner in rat myometrial cells. Fundam. Appl.

Toxicol. 36(Supp):58-59, 1997.

36. Krieger, T. and Loch-Caruso, R. Lindane’s inhibitory effect on myometrial function involves

oxidative stress. Biol. Reprod. 56(Suppl 1):83, 1997.


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37. Wang, C.-T. and Loch-Caruso, R. Role of phospholipid-generated signals in lindane-

mediated inhibition of myometrial gap junctions. Molec. Biol. Cell 8(Supp):418a, 1997.

38. Bae, J. and Loch-Caruso, R. Stimulation of pregnant rat uterine oscillatory contractions by

the PCB mixture Aroclor 1242 involves PLA2-mediated release of arachidonic acid and

activation of voltage-operated calcium channels. Toxicological Sci. 42:102, 1998.

39. Wang, C.-T. and Loch-Caruso, R. A phosphatidylinositol-specific phospholipase C inhibitor

prolonged the time to cessation of spontaneous oscillatory uterine contraction induced by

lindane. Toxicological Sci. 42:102, 1998.

40. Clipson, T. and Loch-Caruso, R. Producers of reactive anion species modulate rat

myometrial function. Toxicological Sci. 42(Supp):102, 1998.

41. Goel, S., Stuenkel, E.L., and Loch-Caruso, R. Lindane inhibits carbachol induced calcium

flux and contractions in uterus. Biol. Reprod. 58(Supp): 200-201, 1998.

42. Clipson, T. and Loch-Caruso, R. A peroxynitrite generator modulates calcium-mediated rat

uterine contractility. Toxicological Sci. 48(Supp):383, 1999.

43. Wang, C.-T. and Loch-Caruso, R. Activation of protein kinase C mediates the inhibitory

effect of lindane on spontaneous uterine oscillatory contraction. Toxicological Sci.

48(Supp):384, 1999.

44. Goel, S. and Loch-Caruso, R. Delta-hexachlorocyclohexane disrupts the actions of

uterotonins in vitro. Toxicological Sci. 48(Supp):384, 1999.

45. Goel, N. and Loch-Caruso, R. Alpha-hexachlorocyclohexane inhibits spontaneous and

oxytocin-induced uterine contractions. Toxicological Sci. 48(Supp):384, 1999.

46. Goel, S., Goel, N. and Loch-Caruso, R. Pacemaker cells of the uterus. Biol. Reprod.

60(Supp 1): 97, 1999.

47. Wang, C.-T. and Loch-Caruso, R. -Tocopherol inhibits activation of the isoform of

protein kinase C and NADPH oxidase-mediated generation of superoxide anion radicals in

lindane-exposed myometrial tissue. Biol. Reprod. 60(Supp 1): 311, 1999.

48. Clipson, T. and Loch-Caruso, R. Guanylate cyclase inhibitor attenuates the relaxation

response of uterine smooth muscle to hydrogen peroxide. Toxicological Sci. 54 (1-S): 363,

2000.

49. Clipson, T. and Loch-Caruso, R. L-Cysteine increases uterine contractility by blocking ATP-

dependent potassium channels. Toxicological Sci., Abstract 1186, 2001

50. Clipson, T. and Loch-Caruso, R. Nitric oxide decreases uterine contractility by blocking the

closure of ATP-dependent potassium channels. Toxicological Sci. 66(1-S): 378 (Abstract

1847), 2002.

51. Chung, D. and Loch Caruso, R. Role of oxidative stress in the modification on rat uterine

contraction by 2, 2'-dichlorobiphenyl. Toxicologist, Abstract 376, 2003.

52. Nasser, F., Chung, D. and Loch Caruso, R. Roles of endocannabinoids in rat uterine

contractions. Biol. Reprod. 68(Supp 1): 272 (Abstract 390), 2003.

53. Brant, K. and Loch Caruso, R. iPLA2 contributes to the gestation day sensitivity to 2,2',4,6-

tetrachlorobiphenyl-induced stimulation of contraction frequency in rat uterus. Biol. Reprod.

68(Supp 1): 269 (Abstract 382), 2003.


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54. Loch-Caruso, R., Tsuneta, T. Hanna, M., Grindatti, C., Quensen, J.F., III and Boyd, S. A.

Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on

rat uterine contraction in vitro. Toxicologist 78(1-S), Abstract 363, 2004.

55. Brant, K.A. and Loch-Caruso, R. Gestational increases and activation of rat uterine

phospholipase A2 enzyme expression mediates PCB 50 – induced stimulation of uterine

function. Toxicologist 78(1-S), Abstract 362, 2004.

56. Chung, D. and Rita Loch-Caruso, R. Role of gap junctions in the modification on rat uterine

contraction by 2,2'-dichlorobiphenyl. Toxicologist 78(1-S), Abstract 1073, 2004.

57. Brant, K.A. and Loch-Caruso, R. In vivo exposure of pregnant rats to PCB 153 stimulates

uterine contractility in vitro. Biol. Reprod. (Special Issue), Abstract 316, 2004.

58. Chung, D. and Loch-Caruso, R. Mitogen-activated protein kinase is involved in 2,2'-

dichlorobiphenyl-induced inhibition of myometrial gap junctions. Biol. Reprod. (Special

Issue), Abstract 564, 2004.

59. Brant, K. Caruso. R. Loch and Flatley, E. PCB 50- and TNF-induced release of arachidonic

acid and prostaglandins from late gestation rat amnion fibroblast cells is associated with

increased expression of calcium independent phospholipase A2. Biol. Reprod. (Special Issue),

Abstract 230, 2005.

60. Chung, D. and Loch-Caruso, R. 2,2'-Dichlorobiphenyl decreases amplitude and

synchronization of uterine contractions through MAPK-mediated phosphorylation of

Connexin43. Biol. Reprod. (Special Issue), Abstract 229, 2005.

61. Thiex, N.W. and Loch Caruso, R. Decline in 15-hydroxy prostaglandin dehydrogenase

activity in human placental and chorionic cells exposed to polychlorinated biphenyls. Biol.

Reprod. (Special Issue), Abstract 60, 2005.

62. Brant, K.A. and Caruso, R.L. Stimulation of PGE2 from human amnion fibroblast cells

following exposure to PBDE 47. 1st International Summit - Preterm Birth, Abstract 39, 2005.

63. Brant, K.A., Thiex, N.W. and Caruso, R.L. Polybrominated diphenyl ethers stimulate the

release of pro-inflammatory cytokines from term human gestational membranes. Toxicologist

90, Abstract 1553, 2006.

64. Brant, K., Guan, W., Tithof, P. and Loch Caruso, R. Phospholipase A2 expression and

activity in late gestation rat amnion and placenta. Biol. Reprod. (Special Issue), Abstract 481,

2006.

65. Thiex, N.W., Thiel, S.R. and Loch-Caruso, R. Measurement of inflammation-stimulated

prostaglandins from human gestational membranes. Reproductive Sciences 14(1S):192A,

Abstract 479, 2007.

66. Miller, M., Chernyak, S.M., Chames, M.C. and Loch-Caruso, R. Variation, levels and congenr

profiles of polybrominated diphenyl ethers (PBDEs) in human gestational membranes. The

Toxicologist – Supplement to Toxicol. Sci. 102(S-1). Abstract 1520, 2008.

67. Tetz, L.M and Loch-Caruso, R. Mono-2-ethylhexyl phthalate stimulated release of the

proinflammatory cytokine interleukin-6 in human gestational membrane cultures. The

Toxicologist – Supplement to Toxicol. Sci. 102(S-1). Abstract 1521, 2008.

68. Miller, M.F. and Loch-Caruso, R. Comparative analysis of punch versus transwell systems

for assessing cytokine induction from human gestational membranes. Reprod. Sci. 16(3)

Suppl:163A, Abstract 327, 2009.


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69. Loch-Caruso, R.K., Thiex, N.W. and Chames, M.C. Amnion and choriodecidua exhibit

distinct patterns of response to LPS with evidence of inflammatory signaling across the

extraplacental membranes in two−compartment Transwell cultures. Reprod. Sci. 16(3)

Suppl:207A-208A, Abstract 484, 2009.

70. Tetz, L. M. and Loch-Caruso, R. Mono-2-ethylhexyl phthalate stimulated release of oxidant

species is inhibited by the flavin-dependent enzyme inhibitor, diphenyliodonium in a human

first trimester extravillous trophoblast cell line. The Toxicologist – Supplement to Toxicol.

Sci. 114(S-1), Abstract 2256, 2010.

71. Jones, S., Boldenow, E., Xi, C., Lieberman, R, and Loch-Caruso, R. Innate immune response

in ex vivo gestational membranes suppresses growth of Group B Streptococcus. J. Women's

Health, 2011, in press. [accepted for poster presentation at the The 19th Annual Congress on

Women's Health 2011]

72. Tetz, L.M. and Loch-Caruso, R. Mono-2-ethylhexyl phthalate increases oxidant species

production and modifies expression of redox-sensitive genes in human placental cells. The

Toxicologist – Supplement to Toxicol. Sci. 120(S-2), Abstract 1052, 2011.

73. Boldenow, E., Jones, S., Xi, C., Lieberman, R. and Loch-Caruso, R. An in vitro model for the

study of bacterial colonization of human extraplacental membranes: role of antimicrobial

peptides. The Toxicologist – Supplement to Toxicol. Sci. 120(S-2), Abstract 2563, 2011.

74. Kimani, P.W. and Loch-Caruso, R. Tetrabromobisphenol A stimulates secretion of

interleukin 6 from human first trimester trophoblasts. The Toxicologist – Supplement to

Toxicol. Sci. 120(S-2), Abstract 1056, 2011.

75. Korte, C.S. and Loch-Caruso, R. Oxidant-induced inflammatory response in human

placental cells is dependent on mitogen activated protein kinases (MAPKs). The Toxicologist

– Supplement to Toxicol. Sci. 120(S-2), Abstract 1057, 2011.

76. Park, H-R, Kimani, P.W., and Loch-Caruso, R. Brominated diphenyl ether-47 stimulated pro-

inflammatory responses in human first trimester trophoblasts. Biol. Reprod. (Special Issue),

Abstract 792, 2011.

77. Hassan, I. and Loch-Caruso, R. Trichloroacetate and dichloroacetate induction of reactive

oxygen species and activation of inflammatory response in extravillous trophoblast cells in

vitro. Biol. Reprod. (Special Issue), Abstract 294, 2011.

78. Park, H.-R., Kimani, P.W. and Loch-Caruso, R. Brominated diphenyl ether-47 enhanced

mRNA expression of pro-inflammatory cytokines and prostaglandin-endoperoxide synthase 2

in human placental cells. The Toxicologist – Supplement to Toxicol. Sci., Abstract #2386 (in

press).

79. Tetz, L.M., Loch-Caruso, R., Giese, R., Wang, P. Mono-2-ethylhexyl phthalate induced

oxidative stress in human placental cells. The Toxicologist – Supplement to Toxicol. Sci.,

Abstract #2383 (in press).

80. Korte, C.S. and Loch-Caruso, R. Oxidative insult activates parturition-associated pathways in

a human placental cell line. The Toxicologist – Supplement to Toxicol. Sci., Abstract #2383

(in press).


24

INVITED PRESENTATIONS

1. Loch-Caruso, R. and Trosko, J.E. Interruption of cell-cell communication in Chinese hamster V79 cells by various alkyl glycol ethers - implications for teratogenicity. Presented at "NIOSH Symposium on Toxic Effects of Glycol Ethers," Cincinnati, OH, September 19-21, 1983.

2. Loch-Caruso, R. Chemical alteration of gap junctional communication in uterine muscle cells. Presented at the EPA/NIEHS workshop on "Mechanisms of Gap Junction Function and Relevance to Disease," Washington, D.C., February 27-28, 1990.

3. Loch-Caruso, R. and Pahl, M.S. Chemical modulation of gap junctional communication in myometrial cultures. Presented at the 1991 World Congress on Cell and Tissue Culture, Anaheim, CA, June 16-20, 1991.

4. Loch-Caruso, R. Chemical modulation of uterine cell and tissue functions. Presented at the Fall Meeting of the Michigan Society of Toxicology, East Lansing, MI, October 23, 1992.

5. Marty, M.S. and Loch-Caruso, R. Altered gap junctional communication and membrane fluidity in rat myometrial cells treated with 2-methoxyethanol. Presented at the Annual Meeting of the Tissue Culture Association, San Diego, CA, June 5-9, 1993.

6. Loch-Caruso, R. In vitro systems for the study of chemical effects on uterine muscle. Presented at the Industrial In Vitro Toxicology Group meeting, New Brunswisk, NJ, June 7, 1994.

7. Loch-Caruso, R., Juberg, D.R. and M.-L. Tsai. Uterine muscle as a target of environmental estrogens. Presented at the Symposium on Environmental Estrogens, sponsored by the Michigan Regional Chapter of the Society of Toxicology and the Midwest Teratology Society, Ann Arbor, MI, October 21, 1994.

8. Loch-Caruso, R. Uterine muscle contraction is modified by cyclic organochlorine chemicals. Presented at the Fourth International Congress on Toxic Combustion Byproducts in Berkeley, CA, June 5-7, 1995.

9. Loch-Caruso, R. Fertility at risk. Presented at the Public Hearing and Conference on Environmental Connection: Rising Rates of Breast Cancer, Reproductive Disorders & Children’s Disease in Ann Arbor, MI, December 1-2, 1995.

10. Loch-Caruso, R. Uterine muscle as a target of environmental toxicants. Presented at the Department of Environmental Health, University of Cincinnati, Cincinnati, OH, January 3, 1996.

11. Loch-Caruso, R. Environmental chemicals and reproduction. Presented to the Student Chapters of the American Women’s Medical Association, University of Michigan, Ann Arbor, MI, April 10, 1997.

12. Loch-Caruso, R. A mechanistic-based approach for assessing chemical hazards to parturition. Presented at the workshop on Methods and Measures: Emerging Strategies for Women’s Health Research, University of Michigan, Ann Arbor, MI, July 14-18, 1997.

13. Loch-Caruso, R. Role of disrupted gap junction function in reproductive disorders. Presented at the Symposium on Epigenetic Toxicant-Induced Signal Transduction and Altered Cell-Cell Communication, University of Michigan, Ann Arbor, MI, October 17-20, 1999.

14. Loch-Caruso, R. Assessment and relevance of environmental chemical effects on uterine muscle. Presented at the Institute of Medicine Roundtable, National Academy of Sciences, Washington D.C., October 2-3, 2001.

15. Loch-Caruso, R. Uterine muscle as a potential target of endocrine disrupters. Presented at the Superfund Basic Research Program Symposium on Accessing Risks of Hormonally Active Agents, Gainesville, FL, December 10-12, 2001.


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16. Loch-Caruso, R. Solving the Puzzle: Does PCB = Preterm Child Birth? Presented at the University of Illinois, November 15, 2002.

17. Loch-Caruso, R. Uterine muscle as a target of polychlorinated biphenyls. Presented in the US EPA-sponsored web-based "Risk-e-Learning" seminar on PCBs – Health Effects, December 4, 2002 (accessible on-line at http://www.clu-in.org/conf/tio/pcb_120402/)

18. Loch-Caruso, R. Uterine muscle as a target of polychlorinated biphenyls. Presented in the US EPA-sponsored web-based "Risk-e-Learning" seminar on PCBs – Health Effects, “Encore seminar.” November 19, 2003.

19. Loch-Caruso, R. Does PCB = Preterm Child Birth? Presented at the Endocrinology-Reproductive Physiology Annual Research Symposium, University of Wisconsin, October 15, 2004.

20. Loch-Caruso, R. Public health impacts of the Great Lakes. Presented at the International Association for Great Lakes Research Conference on Great Lakes Ecosystem Forecasting: Improving Understanding and Prediction, Ann Arbor, MI, May 23-27, 2005.

21. Loch-Caruso, R. Laboratory-Based Assessment of Environmental Chemical Hazards to Parturition. Presented at the Symposium on Methodological Issues in Pregnancy Outcome and Disparities Research, Ann Arbor, MI, October 24-25, 2005.

22. Loch-Caruso, R. Pregnancies at Risk Growing Evidence that Chemicals in the Environment Increase Risk for Preterm Birth. Presented in the Program in the Environment Speaker Series, University of Michigan, Ann Arbor, Michigan, January 25, 2006.

23. Loch-Caruso, R. Pregnancies at Risk: The Environmental Pollution Connection with Preterm Birth. Presented at Harvard University, April 26, 2006.

24. Loch-Caruso, R. Pollutant Exposures and Birth Outcome Disparities. Presented at the workshop on Research to Policy: Improving African-American Birth Outcomes, National Press Club, Washington, DC, February 20, 2007.

25. Loch-Caruso, R. The Role of Oxidative Stress in Childbirth. University of Iowa, April 15, 2011.

ritacv 01/30/12

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Documents

CURRICULUM VITAE of RITA LOCH-CARUSO, Ph.D. · PDF fileCURRICULUM VITAE of RITA LOCH-CARUSO, Ph.D. CURRENT EMPLOYMENT Address: Department of Environmental Health Sciences, School of