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CURRICULUM VITAE

MADELEINE VALDES PAHL, MD

Division of Nephrology and Hypertension University of California, Irvine

UCI Medical Center 101 the City Drive South City Towers, Suite 400

Orange, CA 92868 EDUCATION UNDERGRADUATE EDUCATION: California State University, Long Beach Did not obtain degree; transferred after three years to UCI Medical School in 1974 MEDICAL SCHOOL: University of California, Irvine College of Medicine -Received M.D.

degree in 1978 POST-GRADUATE EDUCATION: Internship in Internal Medicine, University of California, Los

Angeles, San Fernando Valley Program, Sepulveda, California, 1978-1979

Resident in Internal Medicine, University of California, Irvine, UCI

Medical Center, Orange, California, 1979-1980 Fellow, Division of Nephrology, UCI Medical Center, Orange,

California, 1980-1982 Chief Medical Resident, 1982-1983 LANGUAGES Spanish MEDICAL LICENSURE California G 040573 1979 PROFESSIONAL CERTIFICATION BOARDS American Board Internal Medicine, 1983

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American Board Internal Medicine Subspecialty, Nephrology, 1984

ACADEMIC POSITIONS: Assistant Professor of Medicine University of California, Irvine 1983-1990 Associate Professor of Medicine University of California, Irvine 1990-2012 Professor of Medicine University of California, Irvine 2012-Present Director, Outpatient Renal Clinic, 1983-2013 Director, Research Operations Office of Translational Science,

ICTS 2005- present

UCI Institute of Clinical Translational Science Director Regulatory Knowledge and Support Unit, 2005- 2014

Associate Director Acute Dialysis Program 2013- 2014 Nephrology Fellowship Training Program Director University of California, Irvine 2009-2016 Chief of Division of Nephrology and Hypertension University of California, Irvine 2011-2012 Member, Division of Nephrology and Hypertension Harbor-UCLA Medical Center 2017-present PROFESSIONAL ACTIVITY

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AWARDS and HONORS: Intern of the Year, 1979 Voted Outstanding House Officer, 1982 Golden Apple Award, 1984 Kaiser Permanente Award, 1987 Faculty Career Development Award, 1988 Clinical Teaching "Attending of the Year," 1990- 1991

Castle Connolly Top Doctors®, 2014, 2015, 2016 The Best Doctors in America®: Pacific Region, 1996-97, 1997-98, 2009-10, 2011-2012, 2012-2013 Southern California Super Doctors, 2013,2015-16

Golden Apple Award, 1999 Dean’s Award for Compassion, University of California, Irvine, College of Medicine, 2002 Academic Senate Award for Distinguished Service,

Promotions & Honors Committee, 2000-2003 Guide to America’s Top Physicians, Consumers’ Research Council of America, 2008

Physicians of Excellence Award, Orange County Medical Association, 2010, 2015

SERVICE TO PROFESSIONAL National Kidney Foundation, 1985-Present, SOCIETIES

Co-Chair, Clinical Symposium Planning Committee National Kidney Foundation, 1996 Chair, Clinical Symposium Planning Committee, National Kidney Foundation, 1997 & 1998 Research Committee, National Kidney Foundation, 1999 American College of Physicians, Member, 1978-1989 Fellow, 1989-Present Member of Governor’s Council, 2003-2005

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Abstract Review Committee, American Society of Nephrology National Meeting 2006, 2011, 2014 Phi Delta Epsilon Medical Fraternity, 1975 International Society of Nephrology, 1983-Present, member American Society of Nephrology, 1991-Present, member American Federation of Clinical Research, 1989 Western Association of Physicians, 2007-Present Life Member of the National Registry of Who’s Who, #161998, 2001 University Kidney Research Organization, Scientific Advisory Board, Grant Review Committee, UKRO Pilot Research Grants, 2010, 2014

AD HOC SERVICE AS REVIEWER OF MANUSCRIPTS & REFEREE OF PROPOSALS Manuscripts

American Journal of Kidney Disease 1998-current Journal National Medical Association-2005-current Journal of the American Medical Association Journal American Society of Nephrology – 2000-current Kidney International – 2000-current Nephron 1998-current Human Molecular Genetics – 2007 – current Metabolism, 2009 – current Journal of Endourology PLoS One 2014-current BMC Nephrology 2015-current BMC Urology 2015-current Nephrology Dialysis and Transplantation 2015- current Referee of proposals Institute of Clinical Translational Science 2000-current

MEMBERSHIPS IN PROFESSIONAL ORGANIZATIONS: American College of Physicians, Member, 1978-1989

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Fellow, 1989-Present Member of Governor’s Council, 2003-2004 Phi Delta Epsilon Medical Fraternity, 1975 International Society of Nephrology, 1983-Present National Kidney Foundation, 1985-present Chair-Elect, Clinical Symposium Planning Committee, 1996 Chair, Clinical Symposium Planning Committee, 1997 American Federation of Clinical Research, 1989-1990 American Society of Nephrology, Member, 1991-present Fellow, 2012- present Life Member of the National Registry of Who’s Who, #161998,

2001

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BIBLIOGRAPHY PUBLICATIONS 1. Vaziri, N.D., Thomas, R., Sterling, M. Seiff, K., Pahl, M.V., Davila, J., and Wilson, A.: Toxicity with

intravenous injection of crude marijuana extract. Clinical Toxicology 16:353-366, 1981. 2. Elias, A.N., Pahl, M.V., Stone, S., Vaziri, N.D., and Valenta, L.: Modulatory role of GABA in the

regulation of gonadotropin secretion in patients with chronic renal disease. Int. J.Artif. Organs 5(1):13-16, 1982.

3. Vaziri, N.D., Mirahmadi, M.K., Barton, C.H., Eltorai, I., Gordon, S., Byrne, C., Pahl, M.V.:

Clinicopathological characteristics of dialysis patients with spinal cord injury. J. Amer. Paraplegia Soc. 6(1):3-6, 1983.

4. Pahl, M.V., and Vaziri, N.D.: In vivo and in vitro hemodialysis studies of thiocyanate. J. of Clinical

Toxicology 19(9):965-974, 1983. 5. Pahl, M.V., Vaziri, N.D., Gordon, S., and Tuero, S.: Cardiovascular pathology in dialysis patients

with spinal cord injury. Artificial Organs 7(4):416-419, 1983. 6. Pahl, M.V., Vaziri, N.D.: Maintenance hemodialysis in end-stage lupus nephritis. Int. J. Artif.

Organs 7(5):243-244, 1984. 7. Pahl, M.V., Vaziri, N.D., Saiki, J., Byrne, C., Ness, R., Upham, T.: Chronic hemodialysis in end-stage

lupus nephritis: Changes in clinical and serological activities. Int. J. Artif. Organs 8(4):423-428, 1984.

8. Vaziri, N.D., Paule, P., Toohey, J., Hung, E., Alikhani, S., Darwish, R., Pahl, M.V.: Acquired deficiency

and urinary excretion of antithrombin III in nephrotic syndrome. Arch. Intern. Med. 144:1802-1803, 1984.

9. Darwish, R., Elias, A., Vaziri, N.D., Pahl, M.V., Powers, D., Stokes, J.: Plasma and urinary

catecholamines and their metabolites in chronic renal failure. Arch. Intern. Med. 144:69-71, 1984.

10. Pahl, M.V., Vaziri, N.D., Ness, R., Barton, C.H.: Central retinal vein thrombosis in hemodialysis

patients. Int. J. Artif. Organs 7(5)275-276, 1984. 11. Barton, C.H., Pahl, M.V., Cesario, T., Vaziri, N.D.: Renal magnesium wasting associated with

amphotericin-B therapy. Amer. J. Med. 77:471-474, 1984.

12. Pahl, M.V., Vaziri, N.D., Ness, R., Nathan, R., Maksy, M.: Association of beta hydroxybutyric acidosis with isoniazide intoxication. Clinical Toxicology 22(2):167-176, 1984.

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13. Chandy, K.G., Pahl, M.V., Vaziri, N.D., Gupta, S.: Acute effects of dialysis on T lymphocytes in patients with end-stage renal disease. J. Clin. Lab. Immunol. 17:119-124, 1985.

14. Pahl, M.V., Vaziri, N.D., Martin, D.C.: Pathology of digestive organs in renal transplant recipients.

JNMA 78(8):721-726, 1986. 15. Pahl, M.V., Vaziri, N.D., Dure-Smith, B., Miller, R., Mirahmadi, M.: Hepatobiliary pathology in

hemodialysis patients: An autopsy study of 78 cases. Amer. J. Gastroenterology 81(9):783-787, 1986.

16. Li, J., Yousefi, S., Sterling, M., Carandang, G., Vaziri, N.D., Pahl, M.V., Cesario, T.: The effect of

corticosteroids and other anti-neoplastic agents on the generation of leukocyte migration inhibitor factor. J. Clin. Lab.Immunol. 22:13-17, 1987.

17. Pahl, M.V., Barton, C.H., Ulich, T., Villalobos, R., Kaupke, C.J.: Renal dysfunction and

microangiopathic changes in a renal transplant patient. Amer. J. Nephrol. 8:72-79, 1988. 18. Pahl, M.V., Vaziri, N.D., Akbarpour, F., Afrasiabi, A., Friis, R.: Effect of rapid weight loss with

supplemented fasting on serum electrolytes, lipids and blood pressure. JNMA 80(7):803-809, 1988.

19. Pahl, M.V., Vaziri, N.D., Leitman, P.S., Nguyen, T.: Effect of renal mass reduction on kidney tissue

concentration of gentamycin following a single dose. Res. Comm. in Chem. Pathol. and Pharmacol. 60(3):405-408, 1988.

20. Vaziri, N.D., Barbari, A., Hollander, D., Vincent, T., Tran, L., Oveisi, F., Pahl, M.V., Bissar, L.: Effect

of experimental azotemia on intestinal transport of butyric acid. Proc. Soc. Exp. Biol. and Med. 190:150-154, 1989.

21. Pahl, M.V., Vaziri, N.D., Barbari, A., Saadai, B., Oveisi, F., Seo, M.: Intestinal absorption of L-

ascorbic acid in rats with renal failure. Proc. Soc. Exp. Biol. and Med. 191(4):332-336, 1989. 22. Barbari, A., Vaziri, N.D., Benavides, I., Chen, Y.T., Pahl, M.V.: Intestinal transport of pyridoxine in

experimental renal failure. Life Sciences 45(7):633-669, 1989. 23. Pahl, M.V., Vaziri, N.D., Benavides, I., Khamiseh, G., Oveisi, F.: Intestinal absorption of vitamin E in

experimental renal failure. Proc. Soc. Exp. Biol. and Med. 193:125-128, 1990. 24. Pahl, M.V., Erickson, R.A., Vaziri, N.D., Khamiseh, G., Oveisi, F., Jam, K., Seo, J., Kutchemeshgi, M.:

Intestinal morphometry and bile acid-induced mucosal injury in chronic experimental renal failure. J. Lab. Clin. Med. 115:572-578, 1990.

25. Pahl, M.V., Barbari, A., Vaziri, N.D., Hollander, D., Sanchez, M., Oveisi, F., Patel, N.: Intestinal

absorption of arachidonic acid in experimental azotemia. Life Sciences 46(23):1649-1656, 1990.

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26. Pahl, M.V., Vaziri, N.D., Seo, M.: Intestinal absorption of carnitine in experimental azotemia. Res.

Comm. in Chemical Path. and Pharmacology 70(3), 1990. 27. Pahl, M.V., Vaziri, N.D.: Gastroduodenal abnormalities in uremia. Int. J. Artif. Organs 14(1):10-12,

1991. 28. Pahl, M.V., Barbari, A., Vaziri, N.D., Hollander, D., Yazdani, Y., Tran, J., Kan, R.: Intestinal

absorption of linoleic acid in experimental renal failure. The Br. J. Nutr. 66(3):467-477, 1991. 29. Hou, S., Orlowski, J., Pahl, M.V., Ambrose, S., Hussey, M., Wong, D.: Pregnancy in women with end

stage renal disease: Treatment of anemia and premature labor. Amer. J. Kidney Disease 21(1):16-22, 1993.

30. Pahl, M.V., Vaziri, N.D., Kaufman, D., Martin D.C.: Childbirth after renal transplantation.

Transplantation Proc. 25(4):2727-2731, Aug. 1993. 31. Tominaga, G.T., Ingegno, M.D., Scannell, G., Pahl, M.V., Waxman, K.: Continuous

arteriovenous hemodiafiltration in post-operative and traumatic renal failure. Amer. J. Surgery 166(6):612-616, Dec. 1993.

32. Novey, H., Pahl, M.V., Haydik, I.B., Vaziri, N.D.: Immunologic studies of anaphylaxis to iron dextran

in patients on renal dialysis. Ann. Allergy 72(3):224-228, March 1994. 33. Pahl, M.V., Vaziri, N.D., Gonzales, E.: Coagulation profile in persons with long-standing

spinal cord injury. J. Am. Paraplegia Soc. 17(3) 133-135, 1994. 34. Felsenfeld, A.J., Jara, A., Pahl, M., Boever, J., Rodriguez, M.: Differences in the dynamics of

parathyroid hormone secretion in hemodialysis patients with marked secondary hyperparathyroidism. J. Am. Soc. Nephrol. 6(5):1371-1378, 1995.

35. Pahl M., Jara A., Bover J., Felsenfeld A.J.: Studies in a hemodialysis patient indicating that

calcitriol may have a direct suppressive effect on bone. Nephron 71(2):218-23, 1995.

36. Pahl M.V., Jara A., Bover J., Rodriquez M., Felsenfeld A. J.: The set point of calcium and the reduction of para thyroid hormone in hemodialysis patients. Kidney International 49:226-231, 1996.

37. Pahl M.V., Vaziri N.D., Oveisi F., Wang J., Ding Y.: Antithrombin III inhibits mesangial cell

proliferation. J. Am. Soc. Nephrol. 7:2249-2256, 1996. 38. Pahl M.V., Wang J., Zhou X.J., Wang X.Q., Tehranzadeh A., Vaziri N.D.: Effects of LDL on cytosolic

[Ca++] in cultured rat mesangial cells. J. Investigative Med. 44:556-560, 1997.

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39. Pahl M.V., Oveisi F., Khamiseh G., Vaziri N.D.: Intestinal absorption and biliary secretion of cholesterol in rats with nephrotic syndrome. Nephrol, Dialysis, Transplantation 13(6):1446-14451, 1998

40. Wang Z.Q., Liang K.H., Pahl M.V., Vaziri N.D.: Effect of heparin on growth and gene expression of

matrix proteins. Nephrol, Dialysis, Transplantation 13(12):3052-3057, 1998 41. Cyrlak D., Pahl M., Carpenter S.E.: Breast imaging case of the day: multiple giant fibroadenomas

associated with cyclosporin A therapy in a renal transplant patient. Radiographics 19(2):549-51, 1998.

42. Holgado R., Haire H., Ross D., Sprague S., Pahl M., Jara A., Martin-Malo A., Rodriguez M., Almaden

Y., Felsenfeld A.J.: Effect of a low calcium dialysate on PTH secretion in diabetic patients on maintenance hemodialysis. J. Bone Mineral Research 15(5):927-35, 2000.

43. Rajpoot D., Pahl M., Clark J.:Nephrotic syndrome associated with Kimura Disease. Pediatr Nephrol

14(6):486-88, 2000. 44. Adler S.G., Pahl M., Seldin M.F.: Deciphering diabetic nephropathy: progress using genetic

strategies. Current Opinions in Nephrology and Hypertension, 9(2):99-106, 2000. 45. Mehta R.L., McDonald B., Gabbai F.B., Pahl M., Pascual M.T., Farkas, A., Kaplan R.M.: A randomized

clinical trial of continuous vs. intermittent dialysis for acute renal failure. Kidney International 60(3) 1154-63, 2001.

46. Pahl M.V., Culver B.D., Strong P.L., Murray J., Vaziri N.D.: The effect of pregnancy on renal clearance

of boron in humans: A study based on normal dietary intake of boron. Toxicological Sciences 60:252-256, 2001.

47. Vaziri N.D., Oveisi F., Culver B.D., Pahl M.V. Andersen M.E., Strong P.L., Murray J.: The effect of

pregnancy on boron renal clearance in Sprague-Dawley rats given boric acid orally. Toxicological Sciences 60:257-263, 2001.

48. Pahl M.V., Nast C.C., Adler S.G: Proteinuria in patients with arterial/arteriolar nephrolsclerosis.

Clinical Nephrology Am J Med 113(6):456-61, 2002. 49. Mehta R.L., McDonald B., Gabbai F, Pahl M.V., Farkas A, Pascual M.T.A., Zhuang S., Kaplan R.,

Chertow G.M.: Nephrology consultation in acute renal failure: Does timing matter? Am J Med 113(6):456-61, 2002

50. Barth J.D., Pahl M., Zhang L., Zonjee M. Vaziri N.: Sonographic reproducibility of a novel approach

in the assessment of centralized access in end-stage renal disease. Int J Clin Pract 57(5):360-362, 2003

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51. Willams Jr. J.H., Pahl M.V., Kwong D., Zhang J., Hatakeyama D., Ahmad K., Naderi M., Kim M., Vaziri N.: Modulation of neutrophil complement receptor-3 expression by pneumococci and pneumococcal vaccine. Clin Science 104:615-625, 2003.

52. The Family Investigation of Nephropathy and Diabetes Research Group: Genetic Determinants of

Diabetic Nephropathy: The Family Investigation of Nephropathy and Diabetes (FIND). JASN 14(7Suppl 2):S202-204, 2003 Jul.

53. Knowler W.C., Plaetke R., Iyengar S., Sedor J., Coresh J., Kimmel P.L., Olson J., Seldin M.F., Elston

R.C., Freedman B.I. on behalf of the Family Investigation of Nephropathy and Diabetes Research Group: The Family Investigation of Nephropathy and Diabetes (FIND): Design and Methods. J Diabetes Complications 19(1):1-9, 2005.

54. Pahl M.V., Vaziri N.D., Connall T., Morrison D., Kim C., Kaupke C.J., Wilson S.E.: Systemic

Upregulation of leukocyte integrins in response to lower body ischemia-reperfusion during abdominal aortic aneurysm repair. J National Medical Association 97 (2):1-8, 2005.

55. Yoon J.W., Gollapudi S., Pahl MV, Vaziri N.D.: Naïve and central memory T-cell Lymphopenia in

end-stage renal disease. Kidney Int 70: 371-376, 2006. 56. Yoon J., Pahl M., Vaziri N.D.: Spontaneous leukocyte activation and oxygen-free radical generation

in end stage renal disease. Kidney Int 2007 Jan;71(2):167-72. Epub 2006 Nov 15.

57. Chao T., Hinds D.A., Shigeta R., Adler S.G., Lee A., Pahl M.V., et al: A Genome-Wide SNP panel for Mexican American Admixture Mapping. Accepted The American Journal of Human Genetics, 2007.

58. Iyengar S.K., Abboud H.E., Goddard K.A.B., Saad M.F., Adler S.G., Arar N.H., Bowden D.W.,

Duggirala R., Elston R.C., Hanson R.L., Ipp E., Kao, W.H.L., Kimmel P.L., Klag M.J., Knowler W.C., Meoni, L.A., Nelson R.G., Nicholas S.B., Pahl M.V., Parekh R. S., Rasooly R.S., Rich S.S., Scavini M., Schelling J.R., Sedor J.R., Sehgal A.R., Shah V.O., Smith, M. W., Winkler C.A., Zager P.G., and Freedman B.I. on behalf of the Family Investigation of Nephropathy and Diabetes Research Group: Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes. Diabetes, 2007 Jun;56(6):1577-85. Epub 2007 Mar 15.

59. Tian C., Hinds D.A., Shigeta R., Adler S.G., Lee A., Pahl M.V., Silva G., Belmont J.W., Hanson R.L.,

Knowler W.C., Gregersen P.K., Ballinger D.G., Seldin M.F.: A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping. Am J Hum Genet. 2007 Jun;80(6):1014-23. PubMed PMID: 17557415; PubMed Central PMCID:

60. Parekh R.S., Kao W.H., Meoni L.A., Ipp E., Kimmel P.L., La Page J., Fondran C., Knowler W.C.,

Klag M.J.; Family Investigation of Nephropathy and Diabetes Research Group: Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the family

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investigation of nephropathy and diabetes. Clin J Am Soc Neph, 2007 Nov;2(6):1156-62. Epub 2007 Oct 10.

61. Schelling J.R., Abboud H.E., Nicholas S.B., Pahl, M.V., et al: Genome-Wide scans for estimated

glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes. Diabetes, 2008 Jan;57(1):235-43. Epub 2007 Nov 14.

62. Arar N.H., Freedman B.I., Adler S.G., Iyengar S.K., Chew E.Y., Davis M.D., Satko S.G., Bowden

D.W., Duggirala R., Elston R.C., Guo X., Hanson R.L., Igo Jr. R.P., Ipp E., Kimmel P.L., Knowler W.C., Monlineros J., Nelson R., Pahl M.V., et al on behalf of the Family Investigation of Nephropathy and Diabetes Research Group: Heritability of the Severity of Diabetic Retinopathy: The FIND-Eye Study. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3839-45. PMID: 18765632 [PubMed – in process]

63. Kao W.H.L., Klag M.J., Meoni L.A., Reich D., Berthier-Schaad Y., Li M., Coresh J., Patterson N.,

Tandon A. , Powe N.R., Fink N.E., Sadler J., Weir M.R., Adler S., Divers J., Iyengar S.K., Freedman B.I., Kimmel P.L., Kamp K., Kohn O.F., Leehey D.J., Nicholas S., Pahl M., Schelling J.R., Sedor J.R., Thornley-Brown D., Winkler C.A., Smith M.W., and Parekh, R.S., on behalf of the Family Investigation of Nephropathy and Diabetes (FIND) Research Group: MYH9 is associated with non-diabetic end stage renal disease in African Americans. Nature-Genetics, 2008 Oct;40(10):1185-1192. Epub 2008 Sept 14.

64. Moradi H., Pahl M.V., Elahimehr R., Vaziri N.D.: Impaired antioxidant activity of HDL in chronic

kidney disease. Transl Res. 153(2):77-85, 2009 Feb. Epub 2008 Dec 10. PubMed PMID: 19138652.

65. Kamgar M., Zaldivar F., Vaziri N.D., Pahl M.V.: Antioxidant therapy does not ameliorate

oxidative stress and inflammation in patients with end-stage renal disease. J Natl Med Assoc. Apr 101(4):336-344, 2009. PubMed PMID: 19397224.

66. Pahl M.V., Ni Z., Sepassi L., Moradi H., Vaziri N.D.: Plasma phospholipid transfer protein,

cholesteryl ester transfer protein and lecithin: cholesterol acyltransferase in end-stage renal disease (ESRD). Nephrol Dial Transplant 24(8):2541-6, 2009 Aug. Epub 2009 Mar 18. PubMed PMID: 19297356; PubMed Central PMCID: PMC2727299.

67. Vaziri N.D., Moradi H., Pahl M.V., Fogelman A.M., Navab M.: In vitro stimulation of HDL anti-

inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide. Kidney Int. 76(4):437-44, 2009 Aug. Epub 2009 May 27. PubMed PMID: 19471321.

68. Agrawal S., Gollapudi P., Elahimehr R., Pahl M.V., Vaziri N.D.: Effects of end-stage renal disease

and haemodialysis on dendritic cell subsets and basal and LPS-stimulated cytokine production. Nephrol Dial Transplant 2009 Nov 9. {Epub ahead of print] PMID: 19903659

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69. Aminzadeh, A., Pahl, M.V., Barton, C.H., Dotor, N.S., Vaziri, N.D.: Human uremic plasma

stimulates release of leptin and uptake of tumor necrosis factor- in visceral adipocytes. Nephrol Dial Transplant. 2009 Dec;24(12):3626-31. Epub 2009 Aug 7. PMID: 19666662.

70. Gollapudi P., Yoon, J.W., Gollapudi, S., Pahl, M.V., Vaziri, N.D.: Leukocyte Toll-Like Receptor

Expression in End-Stage Kidney Disease Am J Nephrol. 2010 Jan 15;31(3):247-254. [Epub ahead of print]PMID: 20090311

71. Pahl M.V. , Gollapudi S., Sepassi L., Gollapudi P., Elahimehr R., Vaziri N.D.: Effect of End-Stage

Renal Disease on B Lymphocytes Subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol Dial Transplant 2010 Jan; 25(1):205-12 Epub 2009 Aug 14 PubMed PMID: 19684120.

72. Pahl M.V., Vaziri N.D., Yuen J., Adler S.G.: Upregulation of monocyte/macrophage HGFIN

(Gpnmb/Osteoactivin) expression in end-stage renal disease. Clin J Am Soc Nephrol 2010 Jan;5(1):56-61. Epub 2009 Oct 15. PMID 19833906 [PubMed – in process].

73. Adler S., Pahl M., Abboud H., Nicholas S., Ipp E., Seldin M.: Mexican-American admixture

mapping analyses for diabetic nephropathy in type 2 diabetes mellitus. Semin Nephrol. 2010 Mar;30(2):141-9. PubMed PMID: 20347643.

74. Kim, S., Abboud, H., Pahl, M., Tayek, J., Snyder, S., Tamkin, J., Alcorn, H. Ipp, E. Nast, C., Elston,

R., Iyengar, S. Adler, S.: Examination of association with candidate genes for diabetic nephropathy in a Mexican-American population. Clin J Am Soc Nephrol. 5: 1072-1078, 2010. [Epub ahead of print]PMID: 20299368 [PubMed]

75. Moradi H., Ganji S., Kamanna V., Pahl M.V., Vaziri N.D.: Increased monocyte adhesion-

promoting capacity of plasma in end-stage renal disease-response to antioxidant therapy. Clin Neph. 2010

76. Vaziri N.D., Navab K., Gollapudi P., Moradi H., Pahl M.V., Barton C.H., Fogelman A.M., Navab

M.: Salutary effects of Hemodialysis on LDL Pro-Inflammatory and HDL Anti-Inflammatory properties in Patients with ESRD. J Natl Med Assoc. 2011 Jun;103(6):524-33.

77. Igo RP Jr, Iyengar SK, Nicholas SB, Goddard KA, Langefeld CD, Hanson RL,Duggirala R, Divers J,

Abboud H, Adler SG, Arar NH, Horvath A, Elston RC, Bowden DW, Guo X, Ipp E, Kao WH, Kimmel PL, Knowler WC, Meoni LA, Molineros J, Nelson RG, Pahl MV, Parekh RS, Rasooly RS, Schelling JR, Shah VO, Smith MW, Winkler CA, Zager PG, Sedor JR, Freedman BI; Family Investigation of Nephropathy and Diabetes Research Group. Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol.;33(5):381-9, 2011 Epub 2011 Mar 31. PubMed PMID: 21454968.

78. Lee HJ, Pahl MV, Vaziri ND, Blake DR. Effect of hemodialysis and diet on the exhaled breath

methanol concentration in patients with ESRD. J Ren Nutr May;22(3):357-64.2012.Epub 2011 Nov 18. PubMed PMID:22100775.

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79. Lee HJ, Meinardi S, Pahl MV, Vaziri ND, Blake DR. Exposure to potentially toxic hydrocarbons

and halocarbons released from the dialyzer and tubing set during hemodialysis. Am J Kidney Dis.Oct;60(4):609-16, 2012.Epub 2012 Apr 14. PubMed PMID: 22507911.

80. Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, Desantis TZ, Ni Z, Nguyen TH, Andersen GL.

Chronic kidney disease alters intestinal microbial flora. Kidney Int.Feb;83(2):308-15, 2013.Epub 2012 Sep 19. PubMed PMID: 22992469.

81. Thameem F, Igo RP Jr, Freedman BI, Langefeld C, Hanson RL, Schelling JR,Elston RC, Duggirala

R, Nicholas SB, Goddard KA, Divers J, Guo X, Ipp E,Kimmel PL, Meoni LA, Shah VO, Smith MW, Winkler CA, Zager PG, Knowler WC,Nelson RG,Pahl MV, Parekh RS, Kao WH, Rasooly RS, Adler SG, Abboud HE,Iyengar SK, SedorJR; Family Investigation of Nephropathy and Diabetes Research Group. A Genome-Wide Search for Linkage of Estimated Glomerular Filtration Rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND). PLoS One. 2013 Dec17;8(12):e81888. doi: 10.1371/ journal.pone.0081888. eCollection 2013. PubMed PMID: 24358131; PubMed Central PMCID: PMC3866106.

82. Hatamizadeh P, Ravel V, Lukowsky LR, Molnar MZ, Moradi H, Harley K, Pahl M,Kovesdy CP,

Kalantar-Zadeh K. Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease. Nephrol Dial Transplant. 2013 Nov;28(11):2889-98. doi: 10.1093/ndt/gft411. PubMed PMID:24169614; PubMed Central PMCID: PMC3811063.

83. Molnar MZ, Ichii H, Lineen J, Foster CE 3rd, Mathe Z, Schiff J, Kim SJ, Pahl MV, Amin AN, Kalantar-Zadeh K, Kovesdy CP. Timing of return to dialysis in patients with failing kidney transplants. Semin Dial. 2013 Nov-Dec;26(6):667-74. doi: 10.1111/sdi.12129. Epub 2013 Sep 9. PubMed PMID: 24016076.

84. Wong J, Piceno YM, Desantis TZ, Pahl M, Andersen GL, Vaziri ND. Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD. Am J Nephrol.2014 Mar 8;39(3):230-237. [Epub ahead of print] PubMed PMID: 24643131.

85. Moradi H, Abhari P, Streja E, Kashyap ML, Shah G, Gillen D, Pahl MV, Vaziri ND, Kalantar-Zadeh

K. Association of Serum Lipids with Outcomes in Hispanic Hemodialysis Patients of the West versus East Coasts of the United States. Am J Nephrol. 2015 May 30;41(4-5):284-295. [Epub ahead of print] PubMed PMID:26044456.

86. Iyengar SK; Sedor JR;Freedman BI;Kao L WH; Kretzler M; Keller BJ; Abboud HE; Adler SG; Best

LG; Bowden DW; Burlock A; Chen YI; Cole SA; Comeau ME; Curtis JM; Divers J; Drechsler C; Duggirala R; Elston RC; Guo X; Huang H; Hoffman MM; Howard BV; Ipp E; Kimmel PL; Klag MJ; Knowler WC; Kohn OF; Leak TS; Leehey DJ; Li M; Malhotra A; März W; Nair V; Nelson RG; Nicholas SB; O’Brien SJ; Pahl MV; Parekh RS; Pezzolesi MG; Rasooly RS; Rotimi CN; Rotter JI; Schelling JR; Seldin MF; Shah VO; Smiles AM; Smith MW; Taylor KD; Thameem F; Thornley-

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Brown DP; Truitt BJ; Wanner C; Weil EJ; Winkler CE; Zager PG; Igo, Jr RP; Hanson RL; Langefeld CD on behalf of the Family Investigation of Nephropathy and Diabetes (FIND). Genome-wide association and trans-ethnic meta-analysis for advanced diabetic kidney disease: Family Investigation of Nephropathy and Diabetes (FIND). PLoS Genet. 2015, Aug 25;11(8) e1005352. doi: 10.1371/journal.pgen.1005352. eCollection 2015

87. Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler SG, Bowden DW, Divers J,

Freedman BI, Igo Jr. RP, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR, Sedor JR, Shah VO, Smith MW, Taylor KD, Thameem F, Thornley-Brown D, Winkler CA, Guo X, Zager P, Hanson RL and the FIND Research Group. Selecting SNPs Informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics. 2016 May 4;17:325. doi: 10.1186/s12864-016-2654-x

88. Kumar J, Tran Ngoc-Tram Gia, Schomberg J, Streja E, Kalantar-Zadeh K, Pahl MV. Successful

Conversion from Parenteral Paricalcitol to Pulse Oral Calcitriol for the Management of Secondary Hyperparathyroidism in Hemodialysis Patients. J Ren Nutr. 2016 Jul;26(4):265-9. doi: 10.1053/j.jrn.2016.02.006. Epub 2016 Mar 30

89. Vaziri ND, Khazaeli M, Nunes AC, Harley KT, Said H, Alipour O, Lau WL, Pahl MV: Effects of

end-stage renal disease and dialysis modalities on blood ammonia level. Hemodial Int. 2016

Nov 1. doi: 10.1111/hdi.12510. PMID: 27804262 90. Ghahremani-Ghajar M, Rojas-Bautista V, Lau WL, Pahl M, Hernandez M, Jin A, Reddy U,

Chou J, Obi Y, Kalantar-Zadeh K, Rhee CM: Incremental Hemodialysis: The University of California Irvine Experience. Semin Dial. 2017 Mar 14. doi: 10.1111/sdi.12591. [Epub ahead of print] PMID: 28295607

BOOK CHAPTERS, REVIEWS AND EDITORIALS

1. Pahl, M.V., Vaziri, N.D.: Cancer in end-stage renal disease. In: Handbook of Dialysis.

Boston: Little, Brown and Company, 1988. 2. Pahl, M.V., Vaziri, N.D.: Cancer in end-stage renal disease. In: Handbook of Dialysis.

Boston: Little, Brown and Company, (revised edition), 1991. 3. Adler, S.G., Pahl, M., Seldin, M.F.: Deciphering diabetic nephropathy: progress using

genetic strategies. Current Opinions in Nephrology and Hypertension, 9(2):99-106, 2000. 4. Vaziri, N.D., Pahl, M.V.: Hypertension and Epoetin use in dialysis patients. In: Dialysis Therapy (3rd

Edition), (edited by Nissenson, A. and Fine, R.) Philadelphia: Hanley & Belfus, Inc., 2002.

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5. Pahl, M.V., Culver, B.D., Vaziri, N.D.: Boron and the kidney. J Renal Nutrition Oct 15(4):362-70, 2005.

6. Vaziri, N.D., Pahl, M.V.: Hypertension and Epoetin use in dialysis patients. In: Dialysis Therapy (4th

Edition), (edited by Nissenson, A. and Fine, R.). Philadelphia: Hanley & Belfus, Inc., 2006. (in publication)

7. Vaziri ND, Pahl MV, Crum A, Norris K. Effect of uremia on structure and function of immune

system. J Ren Nutr. 2012 Jan;22(1):149-56 PubMed PMID: 22200433; PubMed Central PMCID: PMC3246616.

8. Pahl MV, Vaziri ND. Immune Function in CKD. In: Chronic Renal Disease. Elsevier, 2014 9. Vaziri ND, Zhao YY, Pahl MV. Altered intestinal microbial flora and impaired epithelial barrier

structure and function in CKD: the nature, mechanisms,consequences and potential treatment. Nephrol Dial Transplant. 2015 Apr 16. pii:gfv095. [Epub ahead of print] Review. PubMed PMID: 25883197

10. Pahl MV, Vaziri ND. The Chronic Kidney Disease-Colonic Axis. Semin Dial. 2015 Apr 9. doi:

10.1111/sdi.12381. [Epub ahead of print] PubMed PMID: 25855516. (6/15)