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Curriculum vitae for:

Søren Holm, born 18. Feb. 1953 in Copenhagen Degrees: Danish Baccalaureate (science), Ballerup Gymnasium 1971

Master of science (physics and mathematics), Copenhagen University 1980.Thesis on experimental microdosimetry. Lic.scient (ph.d.) in medical physics 1987, Copenhagen University. Thesis on dynamic SPECT of the brain Supplementary education, courses etc: Health Physics, DTH 1978. Isotope course, Finsen Institute 1979. Summerschool on Advances in Radiation Protection and Dosimetry in Medicine, Erice, Italien 1979. Professional postgraduate teacher training (math and physics) 1981 NMR, NOVO, November 1984. VMS, Digital A/S, 1988. PET techniques, GEMS PET, Uppsala, 1992 MR for physicists, MR-department, University of Lund, 1996 ESI International week on radiation detectors and imaging in life sciences, Archamps, France 1998 Internal Dosimetry, Radiophysics department, University of Lund, 1999 Audit course, Frederiksberg, 2003 Safety and risk analysis in medical physics. Limassol, 2004 MATLAB-course, DIKU, 2005 MicroPET and microCT, Siemens Preclinical, Knoxville, 2006 Dosimetry – Internal radiation course 2006. DSMF, SIS Herlev, 2006. NACP-course: CT dosimetry and image optimization for medical physicists, Århus, 2010 MR-course, RH, 2011 1st PET/MR Workshop, Tübingen, March 2012 Additional courses for medical doctors specializing in Neurology or Nuclear Medicine, contributing by teaching in SPECT/PET, kinetics, and radiation protection. Participation in international meetings, workshops, symposia, congresses as listed below.

Positions:

Instructor/teaching assistant in physics for students at Copenhagen University in medicine, biology, and chemistry 1976-1980, and for master students in physics (course in health physics) 1982-1983. Professional postgraduate teacher training in math and physics, Metropolitanskolen, Copenhagen 1981 Research grant from the Danish Technical Research Council at department of Neurology, Rigshospitalet, 1982-85.

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Consultant (scientific advisor) for Novo Diagnostic Systems and Scan Detectronics 1985-1987, stationed at Dept. of Clinical Physiology, Finsen Institute 1986 Scientific assistant to professor Niels A Lassen at Dept. of Clinical Physiology, Bispebjerg Hospital (grants from the Lundbeck Foundation and the Medical Research Council) 1987-90 Scientific assistant to professor Olaf Paulson, Dept. of Neurology, Rigshospitalet. 1990-91 Medical Physicist at the PET centre, Rigshospitalet, (grants from The John and Birthe Meyer

Foundation) 1991-1997 Medical Physicist at dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet 1998-2000. Chief Physicist at Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet 2001- Associate Professor (“ekstern lektor”) at Copenhagen University 2007-

Other scientific tasks Reviewer for Phys Med Biol, NeuroImage, J Nucl Med, J Cereb Blood Flow Metab, Eur J Nucl Med Mol Imaging, Acta Oncologica, Ugeskrift for Læger Participant in EU-project (performed 1993-1996). Evaluation of a new type of positron emission tomograph scanner for high resolution images. Organizer (scientific secretary) Human Brain Mapping 1997, Copenhagen Editorial Board Member, Clinical Physiology, 1998- Member of the ”Sundhedsfaglige råd for klinisk fysiologi og nuklearmedicin i HS” 2002-2006 Delegate to EFOMP (Eur Fed Org Med Physics) from the Danish Society for Medical Physics (DSMF) 2003- Member of EFOMP’s scientific committee 2005-2009 Board member of DSKFNM, the Danish Society for Clinical Physiology and Nuclear Medicine 2003-2007 Member of the ”Sundhedsfaglige råd for klinisk fysiologi og nuklearmedicin i Region Hovedstaden” (the Capitol region) 2006- Member of the education council of the Danish Society for Medical Physics, DSMF 2006-2010 President of the Danish Society for Medical Physics, DSMF 2007-2013 Head of national user group for PET/CT, preparing a nationwide tender for PET/CT 2008-9 Member of a working group under IAEA addressing artifacts in PET/CT 2008-12 Participant in a NKS-sponsored project (Nordisk kernesikkerhedsforskning, Nordic nuclear safety research) about calibration of whole-body counters 2010-11. Board member of NSFS (Nordisk Selskab for Strålebeskyttelse, Nordic Society of Radiation Protection) 2011- Organizer of symposium celebrating the 100-anniversary of Niels Bohr’s atomic model: Bohrs atommodel og nuklearmedicinen. Rigshospitalet, November 2013 Award: Prize of honour from DSKFNM 2008.

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Participation in meetings, workshops, symposia, congresses etc. (normally with poster or oral

presentation): Repeated (e.g., yearly) events are listed with *, place and year under first appearance

International Symposium on CBF and Metabolism in Man, Heidelberg 1983 Eur Soc of Clin Inv, Toulouse 1985 *International Symposium on CBF and Metabolism (“Brain”) Lund/Ronneby 1985, Montreal 1987, Bologna 1989, Miami 1991, Sendai 1993, Köln 1995 *European Nuclear Medicine Congress Goslar 1986, Budapest 1987, Strasbourg 1989, Lissabon 1992, Copenhagen 1996, Barcelona

1999, Paris 2000, Wien 2002, Amsterdam 2003, Helsinki 2004, Istanbul 2005, Athen 2006, Copenhagen 2007, München 2008, Barcelona 2009, Wien 2010, Birmingham 2011, Milano 2012, Lyon 2013

*Society of Nuclear Medicine annual meeting Washington 1986, St. Louis 1989, Washington 1990, Minneapolis 1995, Toronto 2001, Los

Angeles 2002, Philadelphia 2004, New Orleans 2008, Miami Beach 2012, Vancouver 2013 *Nordisk CBF-møde Fåborg 1989, Lund 1990, Sørup 1991, Malmø 1992, Hillerød 1993, Höör 1994, Helsingør

1995, 1997 NordPET, Copenhagen, December 1989 International meeting on iodinated receptor ligands, Bruxelles, October 1989. Invited talk: "Acquisition requirements for SPECT with I-123". Brain Work Imaging (Alfred Benzon symp. no 31) Vid. Selskab, Copenhagen, Aug. 1990 Symposium on Migraine and other headaches, Copenhagen, November 1990 Symposium om Retained brain tracers, Firenze, November 1991 Invited talk: "Quantitation of brain perfusion with SPECT using brain retained tracers". Benzodiazepin-receptormeeting, Vid. Selskab, Copenhagen, May 1992. Invited talk: "Is quantitation possible with SPECT and PET?" ECD symposium, Copenhagen, July 1992 Brain and Mind symposium, Vid. Selskab, Copenhagen, August 1992 *GE PET users meeting: Jülich, Oct. 1992, Duke NC, USA March 1993, Tübingen Oct. 1994, New York April 1996,

Bethesda Md USA Sept 1998 1st European workshop on epilepsy surgery, Copenhagen, April 1993.

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Invited talk: "Methodological considerations. SPECT and PET-machines." *Brain PET Akita 1993, Oxford 1995, Bethesda 1997, Copenhagen 1999 X Scandinavian Congress in Clinical Physiology. Copenhagen, August 1993 *Human Brain Project Workshop, Minneapolis August 1993, Boston November 1994, Copenhagen April 1995. *Small animal scanner network meeting, Hammersmith February 1994, Bruxelles February 1996 EC-meeting on 3D PET, Louvain la Neuve April 1994 *IEEE NS and MIC Norfolk 1994, San Francisco 1995, Seattle 1999, Dresden 2008, Orlando 2009 Workshop on Dopamin transporter quantitation, RH, 5.May 1995 Workshop on PET instrumentation for animal imaging, San Francisco 1995 *Human Brain Mapping Boston 1996, Copenhagen 1997, Montreal 1998 Hypoxia in malignant tumors, RH, November 1997. International workshop on non-invasive imaging of tumor hypoxia, Århus, November 1998. The VIII symposium on the medical application of cyclotrons. Turku, May 1999. HiRes '99, High resolution in small animals with PET, MR, and other modalities. Amsterdam, September 1999. ESPR (Eur Soc Pediatr Res) congress. Copenhagen, June 1999. Invited talk: ”The principle of SPECT and PET for measurement of rCBF” Symposium on ”Mechanisms to secure tissue oxygenation in humans; adaptive and evolutionary aspects.” Vid. Selskab, Copenhagen, November 2000 XII Scandinavian Congress of Clinical Physiology and Nuclear Medicine, Århus, April 2001 Molecular Imaging Symposium, Zürich, May 2001 Barcelona PET Conference, Barcelona, October 2001 *DSKFNM årsmøder (yearly meetings of the Danish Society of Clinical Physiology and Nucl Med)

Karrebæksminde 2001, Rebild 2002, Helsingør 2003, Rebild 2004, Helsingør 2005 (mødeleder: Billedbehandling), Rebild 2008, Helsingør 2009, Vingsted 2010, Vingsted 2012, Korsør 2013

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The IX symposium on the medical application of cyclotrons. Turku, May 2002. 1. DSMF symposium. Dalum, March 2003 Scandinavian PET Winter symposium. Lillehammer, March 2003 Invited talk: The PET scanner – Reconstruction of images. VIII European Congress on Medical Physics and Engineering, Eindhoven Holland, May 2003 2. Malmö-mötet om Kvalitet i Strålskyddsarbetet. Malmø, February 2004 2. DSMF symposium. Dalum, April 2004. Invited talk: New experimental techniques, PET-CT. II EFOMP Mediterranean Conference on Medical Physics, Limassol Cypern, April 2004 Segerfalk Symposium. Lund, May 2004 The X Turku PET symposium. Turku, May 2005. *DSKFMN ½-års møde. Odense, June 2005, June 2006. Risø, June 2007, Odense, May 2008 Nordic Society for Radiation Protection (XIV). Radiological Protection in Transition. Rättvik, September 2005. 1st AAPM/EFOMP scientific symposium. Advances in imaging and radiation therapy. Nürnberg, September 2005. 14. International Conference of Medical Physics. Nürnberg, September 2005. Röntgenveckan. Malmø, September 2005. Invited talk: PET-CT, technique and physics First Danish Workshop on particle therapy (Danlite). Siemens Danmark, November 2005. GE Medical Advisory Board. Milano, November 2005. Brain Storm Symposium 2006. Birthday symposium for Albert Gjedde. Århus, January 2006. 4. DSMF symposium. Odense, March 2006. Workshop on Medical Applications of the X-ray Compact Light Source. Panum, June 2006. 6th International symposium on Functional Neuroreceptor Mapping. Rigshopitalet, July 2006 EFOMP/SEFM European Day on Medical Physics Training. Màlaga, October 2006 *RSNA. Chicago, November 2006, November 2012 5. DSMF symposium. Odense, March 2007

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EFOMP X Congress, Pisa, September 2007 Nordic Society for Radiation Protection (XV). Ålesund, May 2008 NACP/IGRT symposium, Århus, June 2008 European Conference on Medical Physics and Engineering, Krakow, September 2008 Siemens Biograph User Club, Göteborg March 2009 7. DSMF symposium. Odense, May 2009 3rd Malmö Conference on Medical Imaging: Optimization in x-ray and molecular imaging. Malmö, June 2009. Advanced Intra-operative Imaging of Radioisotopes. (8th international thematic workshop). Presymposium on TOF-PET. Baia delle Zagare, Italien, September 2009 8. DSMF symposium. Odense, April 2010 Third European IRPA Congress, Helsinki, Finland, June 2010. Invited talk: "Optimization of Protection in Paediatric PET-CT. DSR/DSKFNM Scientific meeting, Odense, January 2011 DSMMR Årsmøde, Middelfart, 12. April 2011 Acta/NACP (9. DSMF) Symposium), Uppsala, Sverige, April 2011 EU/EFOMP workshop: European Commission guidelines on Medical Physics Expert, Sevilla, Spanien, May 2011 XII Turku PET symposium, Turku, Finland, May 2011 Nordic Society for Radiation Protection (XVI). Reykjavik, August 2011 European Workshop to introduce RP162 (Acceptability criteria for medical equipment...), Malahide, Dublin, Irland, September 2011 PIANOLIB workshop, Göteborg, September 2011 10. DSMF Symposium, Nyborg Strand, April 2012 IRPA 13, Glasgow, May 2012 DSR/DSKFNM scientific meeting, Århus, January 2013 11. DSMF Symposium, Odense, May 2013

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PSMR2013, Aachen, May 2013 Siemens Biograph user meeting, Århus, January 2014 DSR/DSKFNM Scientific meeting, Odense, January 2014

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Other presentations (scientific societies, colloquia etc.)

Colloquium at Service Frederic Joliot, Orsay, March 1984. SPECT with Tomomatic 64-3. Invited talk at Amersham International, Amersham, May 1985. Dynamic SPECT. Symposium, High resolution scintitomography of cerebral blood flow, Gasthuisberg, Leuven, November 1986. Invited talk: "Performance analysis of the NOVO multidetector brain SPECT scanner." Scientific meeting, RH afd. B, January 1990. Invited talk: Nuclear cardiology methods. PET. Invited talk in Dansk Selskab for Neurovidenskab, April 1991. PET og SPECT. Invited talks in DSKFNM (Dansk Selskab for Klinisk Fysiologi og Nuklear Medicin): 28. Nov. 1991 about SPECT 5. March 1992, PET with FDG 30. Oct. 1992, about PET at Rigshospitalet Invited talk at Århus Kommunehospital 21. June 1993. "Metodologiske problemer ved PET-skanning." Neurolite launch symposium, Herlev, December 1993. Invited talk: "Split-dose/activation." Invited talk at Sokoloff´s laboratory at NIH, April 1994. "The lumped constant of the PET-FDG method: A reevaluation by different techniques" (with Steen Hasselbalch) Invited talk at UTHSC Dallas, June 1995. "Radioisotope based methods for determination of CBF in man." Invited talk at Turku PET center, January 1997. "Physical aspects of brain PET activation studies with H2

15O bolus injection." Invited talk (paid by Nycomed Amersham) at Hedmark Sentralsjukehus, Elverum, Norge November 1999. "Måling af CBF på gammakamera, fysiske aspekter". Invited talk at Symposium for prof. Olaf B. Paulson, RH August 2000. “Kritisk evaluering af Kety-Schmidt teknikken.” Invited talk at the 40 years anniversary of the Dept. of Clinical Physiology at Bispebjerg Hospital: ”Metoder og apparatur; nuværende og fremtidige krav/ønsker.” October 2003. Invited talk at DSKFNM ½-års meeting, Odense, June 2004 (with Lars Thorbjørn Jensen). Akutte stråleuheld på skadestuer og nuklearmedicinske afdelinger.

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Teaching:

Repeated events are listed with *, ( place and) year at first appearance.

(Most courses are given in Danish language, and the Danish titles are kept here)

Kursus om hjernens gennemblødning og blod-hjerne barriere. RH, December 1984. Flow kinetik. Kursus i cerebral hæmodynamik, RH 1986 *Kursus i Matematik for Kliniske Fysiologer (A-kursus), April-May 1990, Oct.-Nov. 1993, 1996, 1999, March-April 2003, Oct.-Nov. 2006, March-April 2009, Sept.-Nov. 2012 Brain Imaging Kursus i hjernens patofysiologi for neurologer og kliniske fysiologer, Neurologisk afd. RH September 1990. Tomografisk billeddannelse af hjernen. Basale principper, relevante isotoper. Videregående Isotopkursus for Klin. Fysiologer (A-kursus), KAS Glostrup, November 1990 Nordisk kursus i hjernens patofysiologi. Gilleleje, May 1991. SPECT og PET. Cyklotron og isotoper. "Nyere diagnostiske metoder i Neurologi" (A-kursus) October 1991 Kursus i 3-D billedbehandling. Efterudd.kursus i Dansk selskab for Med. Fysik, October 1991 Brain Imaging Kursus (receptorer), Neurologisk afd. RH November 1991 Kurser i "Radioaktivitet og Strålehygiejne" for laboranter March/April 1992 Kursus i "Radioaktivitet og Strålehygiejne" for laboranter March 1993 Brain Imaging Kursus, Neurologisk afd. RH, March 1993. Isotoper og principper for SPECT og PET. Billeddiagnostiske metoder i neurologi (A-kursus), RH, September 1993. PET, principper og anvendelse i neurologisk forskning. Videregående isotopkursus (A-kursus), March 1994. SPECT. Brain Imaging Kursus, Neurologisk afd. RH October 1994. PET kursus, RH December 1994. PET og SPECT, principper og teknik. Kursus i ”Arbejde med radioaktive isotoper” for personale i Finsencentret, November 1995. *Medical Imaging Course (Humanbiologer) Panum og RH. Jan. 96, Aug/Sept. 1996-2007, Jan/Feb. 2008-11: Nuklearmedicinske undersøgelser. Fysiske principper. Tracere og kinetik. Brain Imaging Kursus, Neurologisk afd. RH, March 1996 Ph.D. kursus i isotopteknik, RH, March 1997. Radioaktivitet og stråling, vekselvirkning og detektion. *Videregående isotopkursus (A-kursus), Hvidovre, April 1997, April 2000. SPECT og PET. Isotopkursus for laboranter, RH, May 1998 (*2). Basal strålefysik. *Kursus i nuklearkardiologi (A-kursus), Frederiksberg October 1998, September 2001. Partial volume, betydning for myokardie-SPECT. Brain Imaging Kursus, neurologisk afd. RH, October 1998 Ph.D. kursus, BBH October 1998. Undersøgelsesmetoder i kredsløbsforskning. Hjernegennemblødning. CME-kursus i nuklearkardiologi (efteruddannelse for speciallæger, RH January 1999). Partial volume. PET pharmacokinetic course, Copenhagen 1999 (ved Brain '99) *PET og FDG. Kursus (DSKFNM) for laboranter, sygeplejersker mv. May og August 1999 A-kursus: Hjernen, Bispebjerg, March 2000. SPECT datahåndtering. DSMF efteruddannelseskursus, Herlev, March 2000. PET instrumentering mm. * Isotopkursus ("øvelse" på RH for A-kursus, August Krogh Inst. v/ Jørgen Gomme).March 2000-2013 *Ph.D. Kursus, Functional Imaging, Rigshospitalet November 2000, March 2003, February 2007 SPECT-kursus (DSKFNM), Frederiksberg, September 2002 (arrangør og underviser) *A-kursus i onkologi for nuklearmedicinere, Kamerakrav til PET-undersøgelser, September 2002, 2005, 2008, 2011 *Kursus i PET og PET/CT. Scannere. Strålehygiejne. Rigshospitalet, January 2003, January 2006, March 2007. Videregående isotopkursus (A-kursus). PET. Frederiksberg October 2003. Metodekursus (A-kursus). Attenuationskorrektion. PET og PET/CT, Bispebjerg November 2003.

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*DTU November 2003-2013 Kursus i medicinsk billedbehandling, PET og PET/CT. *Grundlæggende isotopkursus (1 dag). RH, January 2004, June 2006, August 2007, November 2009, September 2010 Kursus i GMP for bioanlytikere, arr. DSKFNM. Strålehygiejniske overvejelser. RH, May 2004 *A-kursus i Hjertepatofysiologi. Kvalitetskontrol og korrektionsmuligheder. FH, September 2004, RH October 2007. Rekonstruktioner/korrektioner i SPECT/PET, RH October 2010, Panum October 2013 Temadag i PET. Dosis til personalet ved PET-undersøgelser. RH, September 2004. Iskæmisk hjertesygdom og myocardiescintigrafi (for bioanalytikere). Attenuationskorrektion, Princip og Praksis. KAS Gentofte, September 2006 (*2) *CT-kursus. Grundlæggende strålefysik og røntgenteknik, kvalitetssikring, February 2005, September/November 2005, December 2006/January 2007, February/April 2008, December 2008/February 2009, January/March 2010, December 2010/March 2011 *ENMS Technologist course (Wien) . PET and PET/CT. March 2006, June 2007, March 2008, June 2009, March 2010, March 2011, April 2012, April 2013 Beredskabsøvelser i traumecentret (Nukleart beredskab). Rigshospitalet, May 2006. Internal radiation dosimetry course. DSMF, SIS Herlev, June 2006.MIRD, Mirdos3, OLINDA. *MAIS, Medicinsk anvendelse af ioniserende stråling. Kursus for Civilingeniører i Medicin og Teknik. Efterår 2007, 2008, 2009, 2010, 2011, 2012, 2013 EANM, CTE course. Quality control and radiation protection issues in PET and PET/CT facilities. Barcelona, October 2009 Introduktion til medikoteknik 1, Kursus for Civilingeniører i Medicin og Teknik, DTU, September 2010, 2011 Ph.D. kursus: Physics of ionizing radiation. Appl. in Nuclear Medicine Imaging, Panum, October 2010 Videregående isotopkursus (for bioanalytikere m.fl.), Gentofte, January 2011, May 2012, May 2013 PET og PET/CT, 2-dages kursus for diplomingeniører, RH February 2011 Medical Imaging: PET. I patofysiologikursus for Humanbiologi, March 2012 *Videregående isotopkursus (A-kursus). PET og Hybridteknologi. Gentofte, September 2012 CT-kursus. Grundlæggende strålefysik og røntgenteknik. Prof.Højskolen Metropol, Nov. 2012 PET kursus for bioanalytikere og radiografer, RH March 2013 Ph.d. kursus: PET technique and application for molecular imaging. Dosimetry. Panum, March 2013 Kursus for bioanalytikere (DBio): kend dit gammakamera. Glostrup, September 2013 Strålehygiejne ved DEXA-skanning. (Blandet målgruppe). Panum, October 2013

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Supervision:

Supervisor for bachelor- og master students in Medicine and Technology 2008- Anders Nymark Christensen Pernille Thomsen Louise Scheibel Susanne Bekke Martin Lyngby Lassen Joakim Bay Simonsen Cecilie Louise Klyver Katrine B Albrektsen Stina Møller

Supervisor for Medical Physicists according to Danish legislation, ”Sundhedsstyrelsens vejledning nr. 122 af 20/07/1995”, recently replaced by ”Bekendtgørelse 1252 af 11. November 2010” Markus Nowak (2001-2004) Stefan Fuglsang (2001-2005) Thomas Levin Klausen (2001-2005) Troels Jørgensen (2007- 2011) Lasse Rye Aarup (2010 – 2013) Bryan Haddock (2012-

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Informal supervisor, providing method development and experimental support as reflected in publication list, for Masters (theses in human biology og physics) Minna W Pedersen (2002) Troels Jørgensen (2005) ph.d: Klaus Børch (1996) Ian Law (1996) Morten Blinkenberg (1997) Klaus Fuglsang Kofoed (1998) Ulrik Lassen (1998) Christian Meyer (1999) Francisco Alves (2000) Markus Nowak (2001) Annika Eigtved (2001) Kirsten Møller (2001) Michael J Schueller (2001) Jens Hove (2002) Yan Cai (2002) Karen Husted Adams (2004) Malene Fischer (2006) Steven Haugbøl (2007) - and doctoral theses (dr. med.) Sissel Vorstrup (1988) Allan Andersen (1990) Peter Lund Madsen (1993) Gunhild Waldemar (1996) Pia Rubin (1997) Charlotte Videbæk (2002) Steen Hasselbalch (2003) Klaus Fuglsang Kofoed (2005) Egill Rostrup (2006) Kirsten Møller (2007) Ian Law (2007) Lars H Pinborg (2009)

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Ph.d. thesis (”licentiatafhandling”) Holm S. Dynamic SPECT of the Human Brain for measurement of rCBF. A critical appraisal. PhD thesis, Physics Laboratory, University of Copenhagen 1987 (ISBN 87-87438-17-8) Delivered to Faculty of Science at Copenhagen University 1. May 1987. Public defense at the H.C.Ørsted Institute 30. October 1987. List of Publications, papers with peer review. H-index (2014-02-01): 36 1. Lassen NA, Henriksen L, Holm S, Barry DI, Paulson OB, Vorstrup S, Rapin J, Poncin-Lafitte M,

Moretti JL, Askienazy S, Raynaud C: Cerebral blood-flow tomography: xenon-133 compared with isopropylampetamine-Iodine-123: Concise communication. J Nucl Med 1983;24:17-21

2. Lassen NA, Henriksen L, Holm S, Barry DI, Paulson OB, Vorstrup S, Rapin J, Poncin-Lafitte M,

Moretti JL, Askienazy S, Raynaud C: Cerebral blood-flow tomography by SPECT: xenon-133 compared to isopropylampetamine-Iodine-123: Ann Radiol Paris 1983;26:53-58

3. Holm S, Andersen AR, Vorstrup S, Lassen NA, Paulson OB, Holmes RA. Dynamic SPECT of the

brain using a lipophilic Technetium-99m complex, PnAO. J Nucl Med 1985;26:1129-34 4. Holm S, Vorstrup S, Lassen NA. Tomographic cerebral blood flow calculation. J Cereb Blood Flow

Metabol 1985;5:615-618 5. Shirahata N, Henriksen L, Vorstrup S, Holm S, Lauritzen M, Paulson OB, Lassen NA. Regional

cerebral blood flow by xenon-133 inhalation and emission tomography. Normal values and illustrative clinical cases. J Comp Assist Tomogr 1985;9:861-866

6. Paulson OB, Jarden JO, Vorstrup S, Holm S, Godtfredsen J: Effect of Captopril on the cerebral

circulation in chronic heart failure. Eur J Clin Invest 1986;16;124-132 7. Hemmingsen R, Vorstrup S, Clemmesen L, Holm S, Tfelt-Hansen P, Sørensen AS, Hansen C,

Sommer W, Bolwig TG: Cerebral Blood Flow during Delirium Tremens and related clinical states studied with xenon-133 inhalation tomography. Am J Psychiatry 1988;145:1384-1390

8. Gram L, Diemer H, Kjaer L, Fuglsang-Frederiksen A, Holm S, Herning GM, Dam M. Sammen-

lignende undersøgelser imellem forskellige neurologiske billed-(neuroimaging)-teknikker og EEG til lokalisation af focus ved partiel epilepsi. Ugeskrift for Læger 1988;150(40):2381-3

9. Rubin P, Holm S, Friberg L, Videbech P, Andersen HS, Bendsen BB, Strømsø N, Larsen JK, Lassen

NA, Hemmingsen R: Altered modulation of prefrontal and subcortical brain activity in novel diagnosed schizophrenia and schizophreniform disorder: A regional cerebral blood flow study. Arch Gen Psych 1991;48:987-995

10. Madsen PL, Holm S, Vorstrup S, Friberg L, Lassen NA, Wildschiødtz G: Human regional cerebral

blood flow during rapid eye-movement sleep. J Cereb Blood Flow Metabol 1991;11:502-507

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11. Madsen PL, Schmidt JF, Wildschiødtz G, Friberg L, Holm S, Vorstrup S, Lassen NA: Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep. J Appl Physiol 1991;70:2597-2601

12. Madsen PL, Schmidt JF, Holm S, Vorstrup S, Lassen NA, Wildschiødtz G: Cerebral oxygen

metabolism and cerebral blood flow in man during light sleep (stage II). Brain Res. 1991;557:217-220

13. Madsen PL, Schmidt JF, Holm S, Jørgensen H, Wildschiødtz, Christensen NJ, Friberg L, Vorstrup

S, Lassen NA: Mental stress and cognitive performance do not increase overall level of cerebral O2 uptake in humans. J Appl Physiol 1992;73:420-426

14. Madsen PL, Sperling BK, Warming T, Schmidt JF, Secher NH, Wildschiødtz G, Holm S, Lassen

NA: Middle cerebral artery blood velocity, and cerebral blood flow and O2-uptake during dynamic exercise. J Appl Physiol 1993:74:245-250

15. Madsen PL, Holm S, Herning M, Lassen NA: Average blood flow and oxygen uptake in brain

during resting wakefulness. A critical appraisal of the Kety-Schmidt technique. J Cereb Blood Flow Metab 1993:13:646-655

16. Hasselbalch SG, Knudsen GM, Jakobsen J, Holm S, Paulson OB. Estimation of unidirectional

clearance of FDG and glucose across the blood-brain barrier in man. Adv Exp Med Biol 1993:331:25-27

17. Videbæk C, Friberg L, Holm S, Wammen S, Foged C, Andersen JV, Dalgaard L, Lassen NA.

Benzodiazepine receptor equilibrium constants for flumazenil and midazolam determined in humans with the single photon emission computer tomography tracer [123I]iomazenil. European Journal of Pharmacology 1993:249:43-51

18. Friberg L, Andersen AR, Lassen NA, Holm S, Dam M. Retension of Tc-99m-bicisate in the human

brain after intracarotid injection. J Cereb Blood Flow Metab 1994 (Suppl. 1): S19-S27 19. Holm S, Madsen PL, Sperling B, Lassen NA. Use of Tc-99m-bicisate in activation studies by split-

dose technique. J Cereb Blood Flow Metab 1994 (Suppl. 1):S115-S120 20. Hasselbalch SG, Knudsen GM, Jakobsen J, Pinborg Hagemann L, Holm S, Paulson OB. Brain

metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 1994:14:125-131 21. Holm S. Methodological considerations. An overview of SPECT and PET. Acta Neurol Scand 1994:

Suppl 152:159-164 (1. European Workshop on Epilepsy Surgery) 22. Rubin P, Hemmingsen R, Holm S, Møller-Madsen S, Hertel C, Povlsen UJ, Karle A. Relationship

between brain structure and function in disorders of the schizophrenic spectrum: SPECT, CT and psychopathology of first episodes. Acta Psychiatr Scand 1994:90:281-289

23. Rubin P, Holm S, Madsen PL, Friberg L, Videbech P, Andersen HS, Bentsen BB, Strømsø N,

Larsen JK, Lassen NA, Hemmingsen R: rCBF distribution in newly diagnosed schizophrenia and schizophreniform disorder. Psychiatr Res 1994:53:57-75

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24. Fogh T, Nielsen LH, Hansen LK, Holm S, Law I, Svarer C, Paulson OB. Neural estimation of kinetic rate constants from dynamic PET-scans. In: Vlontzos J et al., eds. Neural Networks for Signal Processing IV. IEEE, Piscataway, New Jersey, USA, 1994:616-23

25. Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB. Blood-brain barrier

permeability of glucose and ketone bodies during short-term starvation in humans. Am J Physiol 1995:268: E1161-E1166

26. Madsen PL, Hasselbalch SG, Hagemann-LP, Olsen KS, Bülow J, Holm S, Wildschiøtz G, Paulson

OB, Lassen NA. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 1995:15:485-491

27. Tedeschi E, Hasselbalch SG, Waldemar G, Juhler M, Høgh P, Holm S, Garde L, Knudsen LL,

Klinken L, Gjerris F, Paulson OB. Heterogenous cerebral glucose metabolism in normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 1995;59:608-15.

28. Svarer C, Law I, Holm S, Mørch N, Paulson OB, Hansen LK, Fog T. Estimation of the glucose

metabolism from dynamic PET-scans using neural networks. In: Girosi F et al., eds. IEEE Workshop on Neural Networks for Signal Processing (NNSP '95) 1995:439-48

29. Holm S, Toft PA and Jensen M. Estimation of the noise contributions from blank, transmission and

emission scans in PET. IEEE Trans Nucl Sci 1996:43:2285-2291 30. Hasselbalch SG, Knudsen GM, Holm S, Hageman LP, Capaldo B, Paulson OB. Transport of D-

glucose and 2-fluordeoxyglucose across the blood-brain barrier in humans. J Cereb Blood Flow Metab 1996:16:659-666

31. Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB. Changes in

brain metabolism and cerebral blood flow during acute hyperketonemia. Am J Physiol 1996:33:E746-E751

32. Hasselbalch S, Knudsen GM, Toft PB, Høgh P, Tedeschi E, Holm S, Videbæk C, Henriksen O, Lou

HC, Paulson OB. Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria. Pediatr Res 1996:40:21-24

33. Blinkenberg M, Bonde C, Holm S, Svarer C, Andersen J, Paulson OB, Law I. Rate dependence of

regional cerebral activation during performance of a repetitive motor task: a PET study. J Cereb Blood Flow Metab 1996:16:794-803

34. Blinkenberg M, Rune K, Jønsson A, Holm S, Jensen CV, Paulson OB, Sørensen PS. Cerebral

metabolism in a case of multiple sclerosis with acute mental disorder. Acta Neurol Scand 1996:94:310-313

35. Law I, Svarer C, Holm S, Paulson OB. The activation pattern during suppression, imagination and

performance of saccadic eye movements. Acta Physiol Scand 1997:161:419-434 36. Hasselbalch SG, Madsen PL, Knudsen GM, Holm S, Paulson OB. Calculation of the FDG lumped

constant by simultaneous measurements of global glucose and FDG metabolism in humans. J Cereb Blood Flow Metabol 1998:18:154-160

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37. Børch K, Pryds O, Holm S, Lou H, Greisen G. Regional cerebral blood flow during seizures in

neonates. J Pediatrics 1998:132:431-435 38. Kofoed KF, Carstensen S, Hesse B, Hove JD, Holm S, Jensen M, Haunsø S, Kelbæk H.

Fluorodeoxyglucose uptake in dysfunctional myocardium subtended by an occluded coronary artery. Relation to dobutamine contractile reserve and Sestamibi uptake. Int J of Cardiac Imaging 1998:14:97-104

39. Lassen U, Andersen P, Daugaard G, Holm S, Jensen M, Svarer C, Poulsen HS, Paulson OB.

Metabolic and hemodynamic evaluation of brain metastases from small cell lung cancer with positron emission tomography. Clinical Cancer Research 1998:4:2591-2597

40. Lou HC, Kjær TW, Friberg L, Wildschiødtz G, Holm S, Nowak M. A 15O-H2O PET study of

meditation and the resting state of normal consciousness. Human Brain Mapping 1999:7:98-105 41. Nowak M, Olsen KS, Law I, Holm S, Paulson OB, Secher NH. Command related distribution of

regional cerebral blood flow during attempted handgrip. J Appl Physiol 1999:3:819-824 42. Blinkenberg M, Jensen CV, Holm S, Paulson OB, Sørensen PS. A longitudinal study of cerebral

glucose metabolism, MRI, and disability in patients with multiple sclerosis. Neurology 1999;53;149-153

43. Hasselbalch SG, Knudsen GM, Videbæk C, Hageman LP, Schmidt JF, Holm S, Paulson OB. No

effect of insulin on blood-brain barrier transport and brain metabolism of glucose in humans. Diabetes 1999;48:1915-21

44. Eigtved A, Andersson AP, Dahlstrøm K, Rabøl A, Jensen M, Holm S, Sørensen SS, Drzewiecki

KT, Højgaard L, Friberg L. Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of silent metastates from malignant melanoma. Eur J Nucl 2000;27:70-75

45. Rostrup E, Law I, Blinkenberg M, Larsson HBW, Born AP, Holm S, Paulson OB. Regional

differences in the CBF and BOLD response to hypercapnia. A combined PET and MR study. NeuroImage 2000;11:87-97

46. Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbæk S, Holm S, Paulson OB, Sørensen

PS. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology 2000;54:558-564

47. Alves F, Jensen M, Jensen HJ, Nickles RJ, Holm S. Determination of the excitation function for the

10B(p,n)10C reaction with implications for the production of [10C]carbon dioxide for use as a PET tracer. Appl Rad Isotop 2000;52:899-903

48. Nickles RJ, Jensen M, Paans AMJ, Holm S, Schuller MJ, Vaalburg W. Doppler broadening as a

probe of the chemical environment following oxygen-14 decay. Radiochim Acta 2000; 49. Lapela M, Eigtved A, Jyrkkiö S, Grénman R, Kurki T, Lindholm P, Nuutinen J, Sutinen E, Solin O,

Bjornskov I, Bretlav P, Friberg L, Holm S, Jensen M, Hansen HH, Minn H. Experience in

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qualitative and quantitative FDG PET in follow up of patients with suspected recurrence from head and neck cancer. Eur J Cancer 2000;36:858-867

50. Kofoed KF, Hansen PR, Holm S, Hove JD, Chen K, Jin W, Jensen M, Iida H, Hesse B, Svendsen

JH, Haunsø S, Kelbæk H. Regional myocardial oxygen consumption estimated by carbon-11 acetate and positron emission tomography before and after repetitive ischemia. J Nucl Cardiol 2000:7:228-234

51. Iida H, Law I, Pakkenberg B, Krarup-Hansen A, Eberl S, Holm S, Hansen AK, Gundersen HJ,

Thomsen C, Svarer C, Ring P, Friberg L, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET. I. Theory, error analysis and histostereological comparison. J Cereb Blood Flow Metab 2000:20:1237-51

52. Law I, Iida H, Holm S, Nour S, Rostrup E, Svarer C, Paulson OB. Quantitation of regional cerebral

blood flow corrected for partial volume effect using O-15 water and PET. II. Normal values and gray matter blood flow response to visual activation. J Cereb Blood Flow Metab 2000:20:1252-63

53. Cai Y, Holm S, Jenstrup M, Strømstad M, Eigtved A, Warberg J, Højgaard L, Friberg L, Secher NH.

Electrical admittance for filling of the heart during lower body negative pressure in humans. J Appl Physiol 2000:89:1569-1576

54. Videbæk C, Toska K, Friberg L, Holm S, Angelo HR, Knudsen GM. In vivo measurement of

haloperidol affinity to dopamine D2/D3 receptors by [123I]IBZM and SPECT. J Cereb Blood Flow Metab 2001:21:92-97

55. Pedersen MW, Holm S, Lund EL, Hojgaard L, Kristjansen PE. Coregulation of glucose uptake

and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro. Neoplasia. 2001 Jan-Feb;3(1):80-7.

56. Strauss GI, Møller K, Holm S, Sperling B, Knudsen GM, Larsen FS. Transcranial Doppler

sonography and internal jugular bulb saturation during hyperventilation in patients with fulminant hepatic failure. Liver Transpl 2001:7:352-358

57. Hasselbalch SG, Holm S, Pedersen H, Svarer C, Knudsen GM, Madsen PL, Paulson OB. The 18 F-

fluorodeoxyglucose lumped constant determined in human brain from extraction fractions of 18 F-fluorodeoxyglucose and glucose. J Cereb Blood Flow Metab 2001:8:995-1002

58. Law I, Jensen M, Holm S, Nickles RJ, Paulson OB. Using 10CO2 for single subject characterization

of the stimulus frequency dependence in visual cortex. A novel positron emission tomography tracer for human brain mapping. J Cereb Blood Flow Metab 2001:21:1003-1012

59. Blinkenberg M, Rune K, Jensen CV, Ravnborg MH, Kyllingsbaek S, Holm S, Paulson OB,

Sorensen PS. [Reduced metabolism in cerebral cortex correlates with MRI changes and cognitive dysfunction in patients with disseminated sclerosis]. Ugeskr Laeger 2001:163:3788-92 (Danish)

60. Møller K, Paulson OB, Hornbein T, Colier WJNM, Paulson AS, Roach RC, Holm S, Knudsen GM.

Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metab 2002:22:118-126

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61. Møller K, Strauss GI, Thomsen G, Larsen FS, Holm S, Sperling BK, Skinhøj P, Knudsen GM.

Cerebral blood flow, oxidative metabolism, cerebrovascular carbon dioxide reactivity in patients with acute bacterial meningitis. Acta Anaesthesiol Scand 2002:46:567-578

62. Paulson OB, Born P, Bundesen C, Gade A, Gerlach A, Hansen LK, Holm S, Jensen M,

Kyllingsbaek S, Larsen A, Law I, Rostrup E, Svarer C. [The working brain – how does it look like?]. Ugeskr Laeger 2002:164:2267-75 (Danish)

63. Kofoed KF, Carstensen S, Hove JD, Freiberg J, Bangsgaard R, Holm S, Rabøl A, Hesse B,

Arendrup H, Kelbæk H. Low whole-body insulin sensitivity in patients with ischaemic heart disease is associated with impaired myocardial glucose uptake predictive of poor outcome after revascularisation. Eur J Nucl Med 2002:29:991-998

64. Kofoed KF, Hove JD, Freiberg J, Høst U, Holm S, Kelbæk H. Variability of insulin-stimulated

myocardial glucose uptake in healthy elderly subjects. Eur J Nucl Med Mol Imaging 2002:29:1600-1607

65. Law I, Roach RC, Olsen NV, Holm S, Nowak M, Hornbein TF, Paulson OB. Oxygen delivery to

the brain during behavioral activation at acute normobaric hypoxemia. In: Tomita M, Kanno I, and Hamel E, eds. Brain activation and CBF control. Excerpta Medica. International Congress Series 1235, Elsevier Science. 2002, 87-98

66. Hove JD, Kofoed KF, Wu HM, Holm S, Friberg L, Meyer C, Aldershvile J, Hesse B, Kelbæk H.

Simultaneous cardiac output and regional myocardial perfusion determination with PET and nitrogen 13 ammonia. J Nucl Cardiol 2003:10:28-33

67. Andersen PB, Krabbe K, Leffers AM, Schmiegelow M, Holm S, Laursen H, Müller JR, Paulson OB.

Cerebral glucose metabolism in long-term survivors of childhood primary brain tumors treated with surgery and radiotherapy. J Neurooncol 2003:62:305-313

68. Pinborg LH, Adams KH, Svarer C, Holm S, Hasselbalch SG Haugbøl S, Madsen J, Knudsen GM.

Quantification of 5HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach. J Cereb Blood Flow Metab 2003:23:985-96

69. Hove JD, Iida H, Kofoed K, Freiberg J, Holm S, Kelbæk H. Left atrial versus left ventricular input

function for quantification of the myocardial blood flow with N-13 ammonia and positron emission tomography. Eur J Nucl Med Mol Imaging 2004;31:71-76

70. Freiberg J, Hove JD, Kofoed KF, Fritz-Hansen T, Holm S, Larsson HB, Kelbæk H. Absolute

quantitation of left ventricular wall and cavity parameters using ECG-gated positron emission tomography. J Nucl Cardiol 2004;11:38-46

71. Liptrot M, Adams KA, Martiny L, Pinborg LH, Lonsdale MN, Olsen NV, Holm S, Svarer C,

Knudsen GM. Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling. NeuroImage 2004;21:483-493

72. Hesse B, Meyer C, Nielsen FS, Sato A, Hove JD, Holm S, Bang LI, Kofoed KF, Svendsen TL,

Parving H-H, Opie LH. Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy:

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Normalization by acute angiotensin converting enzyme-inhibition. Eur J Nucl Med Mol Imaging 2004;31:362-8. Epub 2003 Dec 05

73. Adams KH, Pinborg LH, Svarer C, Hasselbalch SG, Holm S, Haugbøl S, Madsen K, Frøkjær V,

Martiny L, Paulson OB, Knudsen GM. A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables. NeuroImage 2004;21:1105-1113

74. Pinborg LH, Adams KH, Yndgaard S, Hasselbalch SG, Holm S, Kristiansen H, Paulson OB,

Knudsen GM. [18F]-altanserin binding to human 5-HT2A receptors is unaltered following citalopram and pindolol challenge. J Cereb Blood Flow Metab 2004;24:1037-1045

75. Rostrup E, Knudsen GM, Law I, Holm S, Larsson HB, Paulson OB. The relationship between

cerebral blood flow and volume in humans. Neuroimage 2005;24:1-11 76. Svarer C, Madsen K, Hasselbalch SG, Pinborg LH, Haugbøl S, Frøkjær VG, Holm S, Paulson OB,

Knudsen GM. MR-based automatic delineation of volumes of interest in human brain PET images using probability maps. NeuroImage 2005;24:969-979

77. Adams KH, Hansen ES, Pinborg LH, Hasselbalch SG, Svarer C, Holm S, Bolwig TG, Knudsen

GM. Patients with obsessive-compulsive disorder have increased 5-HT2a receptor binding in the caudate nuclei. Int J Neuropsychopharmacology 2005;8:391-401. Epub 2005 Apr 1.

78. Nowak M, Holm S, Biering-Sørensen F, Secher NH, Friberg L. “Central command” and insular

activation during attempted foot lifting in paraplegic humans. Hum Brain Mapp 2005;25:259-265 79. Nygård E, Kofoed KF, Freiberg J, Holm S, Aldershvile J, Eliasen K, Kelbæk H. Effects of high

thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease. Circulation 2005;111:2165-70. Epub 2005 Apr 25.

80. Berthelsen AK, Holm S, Loft A, Klausen TL, Andersen F, Højgaard L. PET/CT with IV contrast

can be used for PET attenuation correction in cancer patients. Eur J Nucl Med Mol Imaging 2005;32:1167-1175. Epub 2005 May 21.

81. Klausen TL, Chakera AH, Friis E, Rank F, Hesse B, Holm S. Radiation doses to staff groups

involved in sentinel node operations for breast cancer. Clin Physiol Funct Imaging. 2005;25:196-202.

82. Kjær A, Meyer C, Wachtell K, Olsen MH, Ibsen H, Opie L, Holm S, Hesse B. Positron emission

tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy. Am J Cardiol 2005;96:1692-1698

83. Hasselbalch SG, Madsen K, Svarer C, Pinborg L, Holm S, Paulson OB, Waldemar G, Knudsen GM.

Reduced 5-HT2A receptor binding in patients with Mild Cognitive Impairment. Neurobiol aging; 2008 Dec;29:1830-8. Epub 2007 Jun 4.

84. Frokjaer VG, Mortensen EL, Nielsen FAa, Haugbol S, Pinborg LH, Adams KH, Svarer C,

Hasselbalch S, Holm S, Paulson OB, Knudsen GM. Frontolimbic serotonin 2A receptor binding

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in healthy subjects is associated with personality risk factors for affective disorder. Biol Psychiatry 2008;63:569-76. Epub 2007 Sep 19.

85. Pinborg LH, Arfan H, Haugbol S, Kyvik KO, Hjelmborg JvB, Svarer C, Frokjaer VG. Paulson

OB, Holm S, Knudsen GM. The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined. Neuroimage. 2008;40:1175-80. Epub 2007 Sep 21.

86. Iversen HK, Holm S, Friberg L, Tfelt-Hansen P. Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate. J Headache Pain. 2008;9:177-80. Epub 2008 Apr 10.

87. Hove JD, Rasmussen R, Freiberg J, Holm S, Kelbæk H, Kofoed K. Clinical evaluation of iterative

reconstruction (ordered-subsets expectation maximization) in dynamic Positron Emission Tomography (PET): Quantitative effects on kinetic modeling with N-13 ammonia in healthy subjects. J Nucl Cardiol. 2008;15:530-4. Epub 2008 Apr 16.

88. Marner L, Knudsen GM, Haugbøl S, Holm S, Baaré W, Hasselbalch SG. Longitudinal assessment

of cerebral 5-Ht2A receptors in helathy elderly volunteers: An [18F]-altanserin PET study. Eur J Nucl Med Mol Imaging 2009:36;287-93. Epub 2008 Oct 1.

89. de Nijs R, Holm S, Thomsen G, Ziebell M, Svarer C. Experimental determination of the

weighting factor for the energy window subtraction-based downscatter correction for I-123 in brain SPECT studies. J Med Phys 2010:35;215-22. Epub 2009

90. Olesen OV, Svarer C, Sibomana M, Keller S, Holm S, Jensen J, Andersen F, Højgaard L. A

movable phantom design for quantitative evaluation of motion correction studies on high resolution PET-scanners. IEEE Trans Nucl Sci 2010:57;1116-24

91. Marner L, Knudsen GM, Madsen K, Holm S, Baaré W, Hasselbalch SG. The reduction of

baseline serotonin 2A receptors in mild cognitive impairment is stable at two-year follow-up. J Alzheimers Dis. 2011:23;453-9

92. Blinkenberg M, Mathiesen HK, Tscherning T, Jønsson A, Svarer C, Holm S, Paulson OB,

Hanson LG, Sørensen PS. Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis. Neurological Research 2012:34;52-8

93. Keller SH, Sibomana M, Olesen OV, Svarer C, Holm S, Andersen FL, Højgaard L. Methods for

motion correction evaluation using FDG human brain scans on a high resolution PET scanner. J Nucl Med 2012:53;495-504

94. Lagerburg V, de Nijs R, Holm S, Svarer C. A comparison of different energy window subtraction

methods to correct for scatter and downscatter in I-123 SPECT imaging. Nucl Med Commun 2012:33(7):708-18

95. Pfeifer A, Knigge U, Mortensen J, Oturai P, Berthelsen AK, Loft A, Binderup T, Rasmussen P, Elema D, Klausen TL, Holm S, von Benzon E, Højgaard L, Kjaer A. Clinical PET of neuroendocrine tumors using 64Cu-DOTATATE: first-in-humans study. J. Nucl Med 2012;53:1207-15 [Epub 2012 Jul 10]

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96. Keller SH, Holm S, Hansen AE, Sattler B, Andersen F, Klausen TL, Højgaard L, Kjær A, Beyer T. Image artifacts from MR-based attenuation correction in clinical, whole-body PET/MRI. Magn Reson Mater Phy 2013;26:173-81. [Epub 2012 Sep 21]

97. Andersen FL, Klausen TL, Loft A, Beyer T, Holm S. Clinical evaluation of PET image reconstruction using a spatial resolution model. Eur J Radiol 2013;82:862-9. [Epub 2012 Dec 17]

98. Kjær A, Loft A, Law I, Berthelsen AK, Borgwardt L, Löfgren J, Johnbeck CB, Hansen AE, Keller S, Holm S, Højgaard L. PET/MRI in cancer patients: first experiences and vision from Copenhagen. Magn Reson Mater Phy 2013;26:37-47. [Epub 2012 Dec 25]

99. PET/MR imaging of the pelvis in the presence of endoprostheses: reducing image artifacts and increasing accuracy through inpainting. Ladefoged CN, Andersen FL, Keller SH, Löfgren J, Hansen AE, Holm S, Højgaard L, Beyer T. Eur J Nucl Med Mol Imaging. 2013;40:594-601. [Epub 2013 Jan 8]

100. Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36. Ettrup A, Holm S, Hansen M, Wasim M, Santini MA, Palner M, Madsen J, Svarer C, Kristensen JL, Knudsen GM. Mol Imaging Biol. 2013;15:376-383 [Epub ahead of print Jan 10]

101. Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging. Reichkendler MH, Auerbach P, Rosenkilde M, Christensen AN, Holm S, Petersen MB, Lagerberg A, Larsson HBW, Rostrup E, Mosbech TH, Sjödin A, Kjaer A, Ploug T, Hoejgaard L, Stallknecht B. Am J Physiol Endocrinol Metab 2013;305:E496-E506.[Epub ahead of print Jun 25]

102. Combined PET/MR imaging in neurology: MR-based attenuation correction implies a strong spatial bias when ignoring bone. Andersen FL, Ladefoged CN, Beyer T, Keller SH, Hansen AE, Højgaard L, Kjær A, Law I, Holm S. Neuroimage 2014;84:206-216. [Epub ahead of print Aug 29 2013]

103. Calibrated Image derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET. Christensen AN, Reichkendler MH, Larsen R, Auerbach P, Højgaard L, Nielsen HB, Ploug T, Stallknecht B, Holm S. Nucl Med Comm 2014. [Epub ahead of print Jan 7]

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Book chapters, Proceedings, Editorials

Holm S, Andersen AR, Vorstrup S, Lassen NA, Paulson OB, Kristensen K, Tyrrel DA, Nowotnik DT, Neirinckx RD. CBF measured within 10 seconds using dynamic SPECT and lipophilic technetium compounds PnAO and HMPAO. J Cereb Blood Flow Metabol 1985;/Suppl 1 S565-566 Holm S, Vorstrup S, Lassen NA, Paulson OB. Physical Factors affecting calculated cerebral blood flow values in hypoperfused areas in single photon emission computerized tomography. In: Hartman A, Hoyer S, eds. Cerebral Blood Flow and Metabolism Measurement. Berlin-Heidelberg: Springer Verlag 1985:234-237 Holm S: Snitmåling af hjernens struktur og funktion. Naturens Verden 1986; 213-222 Holm S: Performance analysis of a new brain SPECT scanner. European Nuclear Medicine Congress, 1986, Goslar. Nuklearmedizine, Supplementum 23. Schmidt HAE, Emrich D(eds), Schattauer, Stuttgart 1987 Holm S: Acquisition requirements for SPECT with I-123. International meeting on Iodinated receptor ligands, Bruxelles 1989 (Proceedings) Holm S, Friberg L, Iversen HK, Lassen NA: Dual energy Brain SPECT - methods and applications. European Nuclear Medicine Congress. In: Nuclear Medicine. Quantitative Analysis in Imaging and Function pp.11-13. Schmidt HAE, Chambron J (eds), Schattauer, Stuttgart-New York 1990 Iversen H, Holm S, Friberg L: Intracranial hemodynamics during iv Nitroglycerine infusion. Proceedings from 4. Int. Headache Congress, Sydney. Cephalalgia 1989:9 (suppl. 10) 84-85 Holm S: Radiation doses with xenon-133, xenon-127 and Tc-99m HMPAO. in: Migraine and Other Headaches: The Vascular Mechanisms pp. 43-46. Olesen J (ed), Raven Press, New York 1991

Lassen NA and Holm S: Single Photon Emission Computed Tomography. In: Clinical Brain Imaging: Principles and Applications. Maziotta JC, Gilman SD (eds), Davis Company, Philadelphia 1992 (108-134) Madsen PL, Friberg L, Holm S, Vorstrup S, Lassen NA, Wildschiødtz G: Changes in the regional activation pattern in the normal human brain during dreaming and REM sleep as measured with SPECT. In: Imaging of the Brain in Psychiatry and Related Fields, Maurer K (ed) Berlin: Springer, 1993 Madsen PL, Holm S, Lassen NA: A critical appraisal of the gold standard; global levels of CBF, CMRO2 and CMRglu determined with the Kety-Schmidt technique. In: Uemura K, Lassen NA, Jones T, Kanno I (eds): Quantification of Brain Function. Elsevier, 1993:209-216 Hasselbalch SG, Knudsen GM, Jakobsen J, Holm S, Paulson OB. Unidirectional clearance of D-glucose and FDG across the human blood-brain barrier: A reevaluation of the lumped constant. In: Uemura K, Lassen NA, Jones T, Kanno I (eds): Quantification of Brain Function. Elsevier, 1993:201-208

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Hjortrup A, Højgård L, Kirkegaard P, Hage E, Holm S, Jensen M. Dynamic 18FDG PET for evaluation of liver transplantation.Transplantation 1995;9:18-19 Holm S, Law I, Paulson OB. 3D PET activation studies with an H2

15O bolus injection. Count rate performance and dose optimization. In: Jones T et al (eds), Quantification of brain function using PET. Academic Press, San Diego 1996, 93-97 Svarer C, Law I, Holm S, Mørch N, Hasselbalch S, Hansen LK, Paulson OB. An artificial neural network approach to estimation of the regional glucose metabolism using PET. In: Jones T et al (eds), Quantification of brain function using PET. Academic Press, San Diego 1996, 271-276 Schueller MJ, Mulnix TL, Christian BT, Jensen M, Holm S, Oakes TR, Roberts AD, Nickles RJ. Addressing the third gamma problem in PET. Abstract and proceedings IEEE MIC 2001 Eskild-Jensen A, Holm S, Kragh L, Martiny L, Mortensen J, Oturai P, Rasmussen S, Møller S; Bestyrelsen for Dansk Selskab for Klinisk Fysiologi og Nuklearmedicin . [25th anniversary of the Danish Society of Physiology and Nuclear Medicine](danish). Ugeskr. Laeg. 2007;169:1114 Holm S, Borgwardt L, Loft A, Graff J, Law I, Højgaard L. Paediatric doses - a critical appraisal of the EANM paediatric dosage Card. Editorial, Eur J Nucl Med Mol Imaging 2007:34;1713-8 Holm S. PET/SPECT – CT – Hybridteknikker. Kapitel i ”25 år for Dansk selskab for Klinisk Fysiologi og Nuclear Medicin. Status og Udvikling”. Jubilæumsskrift for DSKFNM, 2007

Sibomana M, Keller SH, Svarer C, Olesen OV, Andersen F, Holm S, Hojgaard L. New attenuation correction for the HRRT using transmission scatter correction and total variation regularization. IEEE conference record, Nuclear Science Symposium & Medical Imaging Conference 2009;3284-3286

Olesen OV, Sibomana M, Keller SH, Andersen F, Jensen J, Holm S, Svarer C, Hojgaard L. Spatial resolution of the HRRT PET scanner using 3D-OSEM PSF reconstruction. IEEE conference record, Nuclear Science Symposium & Medical Imaging Conference 2009;3789-3790

Sibomana M, Keller SH, Holm S, Bloomfield PM, Blinder S, Hansen SB, Michel C. Component-based normalization for the HRRT for sinogram-mode reconstruction. IEEE conference record, Nuclear Science Symposium & Medical Imaging Conference 2009; 2694-2697 Basu S, Zaidi H, Holm S, Alavi A. Quantitative techniques in PET-CT imaging. Current Medical Imaging Reviews, 2011:7;216-33 Holm S, Jødal L. Apparatur. In: Christensen CB, Loft A, Hesse B (eds). Lærebog i Nuklearmedicin (in Danish), Copenhagen 2011, 318-42 Hansen AE, Keller SH, Löfgren J, Holm S. Kombineret PET/MR skanner på Rigshospitalet. Første erfaringer. Medicinsk Teknologi og Informatik 2012;3:9-10

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Selected abstracts, topics not fully covered in the above categories Rossing N, Diemer H, Pedersen F, Holm S, Wong DF, Gjedde A. Blood-brain transfer of [tc-99m]HMPAO in human parietal cortex in vivo. J Nucl Med 1986;27:P888 (A) Wong DF, Lever SZ, Burns HD, Gjedde A, Rossing N, Ravert H, Clausen M, Ely TK, Glodfarb HW, Dannals RF, Diemer N, Holm S, Pedersen F, Lever JR, Scheffel U, Bice AN, Links JM, Woo DV, Wagner HN. Tc-99m NEP-DADT for measurement of regional cerebral blood flow in human beings. Abstract IV world congress (WFNMB), Buenos Aires, Argentina , 1986 (A) Holm S, Andersen A, Lassen NA, Paulson OB, Vorstrup S: Limits of resolution for SPECT with Xe-133, Xe-127 and Tc-99m. J Cereb Blood Flow Metabol 1987/Suppl 1 S565 (A) Holm S, Lapp T, Bärenholdt O. Dual photon absorptiometry (DPA): Preliminary evaluation of a new high precision BMC scanner (abstract ENMC 1987). Nucl Med 1987:26:P75 (A) Friberg L, Olesen J, Holm S, Skyhøj TS, Iversen HK. rCBF measured with SPECT and Xe-133 inhalation is the laboratory examination of migraine patients. J Cereb Blood Flow Metabol 1989/Suppl 1 S366 (A) Lassen NA, Holm S, Petersen RK, Hansen HE, Rommer P: Whole Body multidetector SPECT with variable aperture. J Nucl Med 1989;30:796 (A) Holm S, Friberg L, Iversen HK, Lassen NA: Dual energy Brain SPECT - methods and applications. J Nucl Med 1989;30:1750 (A) Holm S: An error analysis of the Kety-Schmidt method for determination of CBF. 5. Nordiske CBF-møde, Lund 1990 (A) Holm S, Madsen PL, Rubin P, Sperling B, Friberg L, Lassen NA: Tc-99m HMPAO for activation studies: Validation of the split-dose, image subtraction approach: J Cereb Blood Flow Metabol 1991/Suppl 2 S766 (A) Højgård L, Hjortrup A, Kirkegaard P, Hage E, Holm S, Jensen M. Evaluation of livertransplantations with dynamic 18FDG PET imaging. Eur J Nucl Med 1994 (Suppl) S68 (A) Holm S, Law I, Paulson OB. 3D PET rCBF activation studies with H2

15O bolus injection. Count rate performance and dose optimization. J Cereb Blood Flow Metab 1995 (Suppl. 1): S627 (A) Holm S, Law I, Paulson OB. 3D PET activation studies with H2

15O bolus injection. Count rate performance and dose optimization. NeuroImage 1995:2:S17 (A) Schambye RB, Meyer C, Rabøl A, Holm S, Jensen M, Hesse B. The influence of training on myocardial bloodflow and flowreserve measured by PET. Abstr 5th international conference on non-invasive cardiology 1995 (A) Holm S, Law I, and Paulson OB. Count rate performance and dose optimization for rCBF with O-15 water bolus injection in a new 3D PET. J Nucl Med 1995;36:105P (A) Holm S, Ennow K: Effective dose from transmision scan procedures in PET. Eur J Nucl Med 1996:1121 (A) Jensen M, Nickles RJ, Holm S. Carbon-10 dioxide: a new tracer for human brain mapping with PET (abstract HBM98) NeuroImage 1998:7:S630 (A) Nickles RJ, Jensen M, Holm S. Carbon-10 dioxide: reviving steady state PET imaging of rCBF (abstract SNM98) J Nucl Med 1998:39:131P (A) Hove JD, Kofoed KF, Holm S, Wu C, Friberg L, Aldershvile J, Meyer C, Hesse B, Kelbæk H. Comparison of factor analysis for the determination of cardiac output using PET. (abstract 4th Int Conf of Nucl Card 1999) (A) Holm S, Jensen M, Nickles RJ. Effective dose of Carbon-10 dioxide: a new tracer for PET. (Abstract Brain PET 99) J Cereb Blood Flow Metabol 1999 suppl 1:S833 (A) Jensen M, Holm S, Nickles RJ, Alves F. Optimal use of 10CO2 as a PET flow tracer in activation studies. (Abstract Brain PET 99) J Cereb Blood Flow Metabol 1999 suppl 1:S813 (A) Nickles RJ, Jensen M, Schueller MJ, Holm S. PET imaging of regional cerebral blood flow with H2

14O. (abstract VIII conference on Medical Applications of Cyclotrons, Turku 1999) Ann Univ Turku 1999:346:R10 (A) Eigtved A, Jensen M, Holm S, Foder B, Larsen P, Højgaard L, Iversen P, Friberg L. [F-18] fluoro-5-dihydrotestosterone as a PET ligand for androgen receptors in prostate cancer (abstract SNM 1999). J Nucl Med 1999:40:256P (A) Nowak M, Holm S, Secher NH, Friberg L. PET and fMRI during light handgrip exercise: cardiovascular responses and insular activation (abstract HBM99). (A) Jensen M, Nickles RJ, Holm S, Schueller MJ. Direct comparison of 10CO2, H2

14O and H215O in two subjects: Choosing the right

stuff. Abstract SNM 2001. (A) Martin Lyngby Lassen, Flemming Littrup Andersen, Knut Conradsen, Rasmus Larsen, Thomas Beyer and Søren Holm

Optimizing the injection and acquisition scheme for whole-body FDG-PET imaging helps reduce variations in image noise across patients. Abstract SNM 2013 (A)