CURRICULUM VITAE CLAY BRADEN MARSH, M.D. - … Harrold Rotation 5/02 Microarray analysis in murine lungs Internal Medicine Resident Pamela Habib Undergrad Student 7/01/02

Clay B. Marsh, Curriculum Vitae

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CURRICULUM VITAE Updated 9/9/02 CLAY BRADEN MARSH, M.D. Current Address and Phone Number: (Office)

The Ohio State University Medical Center N-325 Means Hall 1654 Upham Drive Columbus, Ohio 43210 Telephone: (614) 293-4925 FAX: (614) 293-4799 E-mail: [email protected]

Personal:

Date of Birth: November 15, 1958 Charleston, West Virginia United States

Education:

West Virginia University, Morgantown, W.V. (Biology), 1977-1981 West Virginia University, Morgantown, W.V. (Medicine), 1981-1985 Ohio State University, Residency, Internal Medicine, 1985-1988 Ohio State University, Research Fellow, Pulmonary and Critical Care Medicine, 1988-1989 Ohio State University, Chief Resident, Internal Medicine, 1989-1990 Ohio State University, Fellow, Pulmonary and Critical Care Medicine, 1990-1992 Ohio State University, Instructor/Extension of Research Fellowship, Pulmonary and Critical Care Medicine, 1992-1995

Board Certification:

National Board of Medical Examiners, 1985 American Board of Internal Medicine, 1988 Pulmonary Medicine, 1993 Critical Care Medicine, 1994

Academic Positions

Clinical Instructor of Medicine/Extended Research Fellowship, Pulmonary and Critical Care Medicine, The Ohio State University, 1993-1995 Assistant Professor of Medicine, Pulmonary and Critical Care Medicine, The Ohio State University, 1995-1998 Associate Professor of Medicine, Pulmonary and Critical Care Medicine, The Ohio State University, 1998- Investigator, The Heart and Lung Research Institute, The Ohio State University, 1998- Associate Director for Education and Research Initiatives, The Heart and Lung Research Institute, The Ohio State University, 2000- Vice Chairman, Research, Department of Internal Medicine, The Ohio State University, 2000-. Joint Appointment, Integrated Biomedical Science Graduate Program, 2000-


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Joint Appointment, Department of Pathology, 2000- Joint Appointment, Department of Molecular Virology, Immunology and Medical Genetics, 2000- Joint Appointment, Department of Veterinary Sciences, 2001- Joint Appointment, Ohio State Biochemistry Program, 2001- Interim Director, Pulmonary and Critical Care Medicine, 2002- Leadership Training, Fisher School of Business, OSU College of Medicine, 2001-

Licensure:

The State of Ohio, 1989- Professional Organizations:

American Thoracic Society, 1989- Ohio Thoracic Society, 1989- American College of Physicians, 1990- American Federation for Medical Research, 1993- American Association for the Advancement of Science, 1993- International Cytokine Society, 1994- American Association of Immunologists, 1995- Federation of American Society for Experimental Biology, 1997- Central Society for Clinical Research, 2000-

Honors and Awards:

Veterans Administration Service Award, 1987 Medical Student Teaching Award, The Ohio State University, 1988 Outstanding Medical Resident Award, The Ohio State University, Department of Internal Medicine, 1988 Alpha Omega Alpha American Federation of Clinical Research Trainee Investigator Award, 1992 James V. Warren Research Award, The Ohio State University Department of Internal Medicine, 1993 Teacher of the year, Department of Internal Medicine, 1997-1998 Faculty member of the year, Landacre Society (student research), 1998-1999 Central Society for Clinical Research, 2000- Faculty Mentor Award, HLRI, 2001 Faculty teaching award, Family Medicine, 2001 Scientific Board, Stanley Sarnoff Foundation, 2001 Lung Biology and Pathology A Study Section, NIH, 2002 America’s Best Physicians Award, 2002

Trainee Awards (Marsh sponsor)

Outstanding oral presentation, 1997, Ohio State University Medical Student Research Landacre Day, Ernest L. Mazzaferri, Jr., B.S. (as first year medical student) National Research Service Award, NIH/NHLBI, Richard W. Pomerantz, M.D. Travel award, National AFMR, 1998, Richard W. Pomerantz, M.D. Travel award, Midwest section, AFMR, 1998, Richard W. Pomerantz, M.D. James V. Warren Award (Outstanding Research Award for Fellows, Department of Internal Medicine), 1999, Richard W. Pomerantz, M.D. AHA Grant-in aid, Anuj Goyal, M.D., 2000-2002


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AMA Leadership Award, Gregory Lam, B.S., 2001 Outstanding Presentation, Christopher Baran, Bennett Student Research Day, 2002

Trainees

David Ralston, M.D. Co-sponsor Wewers, sponsor

Fellow 1992-1995 Role of proteinase-3 in FC-receptor-alpha-1 antitrypsin interaction

Private Practice

Richard W. Pomerantz, M.D.

Fellow 1997-1999 Regulation of monocyte survival.

Private Practice

Todd Kelly M.S. Medical Student and grad student

1997-2000 Cell signaling pathways involved in control of apoptosis in monocytes.

Medical School

Ernie Mazzaferri, Jr.

Summer Roessler MD student

1997-1998 Role of MCSF in monocyte survival

Internal Medicine Residency

Saadia Ahktar, M.D.

M.D. Resident 1998-1999 Role of Fcγ receptors in monocyte responses to growth factors.

Fellowship, University of Washington, Seattle

Sey Lau, M.S.

Medical Student Trainee

Summer fellowship, 1998

Control of apoptosis Medical Council of Canada Med Student Research Trainee

Residency, Internal Medicine, Cleveland Clinic Foundation

Anuj Goyal, M.D. Fellow 1999-2001 Regulation of monocyte survival in response to known survival factors

Private Practice

Nitin Bhatt, M.D. Fellow 1999- Control of monocyte survival by phosphatases

Faculty, Pulmonary and Critical Care Medicine

Keith Niggemyer, M.D. M.D. Resident 1999, 2000

Role of adherence in monocyte survival and differentiation

Resident, Internal Medicine, Ohio State

Gregory Staker, M.D. M.D. Resident 2000 Role of monocytes in TGF-� activation


Peter Mustillo, M.D. M.D. Resident 2000 Role of nitric oxide production in monocyte survival


Frank Lichtenberger, B.S. M.D./Ph.D. Student

3/2000- Monocyte regulation of TGF-� activation

M.D./Ph.D. student and doctoral work

Christine Roos, Ph.D. Ph.D. 7/2000- The role of M-CSF in regulating survival and signal transduction in breast cancer

Post-doctoral researcher

Judy Opalek Ph.D. Student 4/01- Genetic and protein regulation of macrophage differentiation

Ph.D. work

Michele Welage Ph.D. Student 4/01 The role of M-CSF in monocytes angiogenesis

Ph.D. work

Kelly McQuown Ph.D. Student 4/01- The role of PTEN in monocyte survival and differentiation

Ph.D. work

Gregory Lam, B.S. Stanley Sarnoff Foundation Fellow

7/00-7/01 Role of reactive oxygen species in monocyte survival and differentiation

Medical Student, Rochester University, Sarnoff Fellow

Clay B. Marsh, Curriculum Vitae Chris Baran Ph.D. Student 7/01- The molecular targets and

regulation of SHIP and other phosphatases by ITIMs

Ph.D. work

Aaron Kirkpatrick Stanley Sarnoff Fellow

07/01-06/02

Monocyte protection: the role of HSP90

Medical Student, Dartmouth Medical Center

Dan Malleske Medicine-Pediatrics Resident

7/01 The role of cytoskeletal proteins and Abl in regulating monocyte activation

Medicine/Pediatrics Residency

Richard Wardrop, Ph.D. Rotating medical student

10/01-12/01

Signal transduction regulation of SHIP2 in monocytes

MSTP student

Tim Eubank PhD Student 7/01/02- The role of growth factors in regulating angiogenesis

Ohio State Biochemistry student

Brad Harrold Rotation 5/02 Microarray analysis in murine lungs

Internal Medicine Resident

Pamela Habib Undergrad Student

7/01/02- Lung fibrosis in transgenic mice

Ohio State undergrad student

Nithin Johnson Undergrad student

7/01/02- PTEN in monocyte signaling Ohio State undergrad student

Academic Service-National

Counselor, Midwest Section, American Federation for Medical Research, 1997-1998. Moderator and speaker, Midwest Section meeting, AFMR, Chicago, IL, 1998. Member, National Council, American Federation for Medical Research, 1998-. Featured Speaker, Topic: Basic Mechanisms of Inflammation, American College of Clinical Pharmacology National Meeting, Cincinnati, OH 1998. Co-chair, Oxidant injury and signal transduction in the lung, FASEB International Meeting, Washington, DC, 1999. Organizer and speaker, Topic: Apoptosis symposium, American Thoracic Society International Meeting, San Diego, CA, 1999. Chair, American Thoracic Society, AAI Assembly, Membership Committee, 1999-. Associate Editor, Journal of Investigative Medicine, 1999-. Reviewer, Ad-hoc, Journal of Immunology, American Journal of Physiology, American Journal of Respiratory Cell and Molecular Biology President elect, Midwest Section, American Federation for Medical Research, 1998-99 President, Midwest Section, American Federation for Medical Research, 1999-2000 Member, Long Range Planning Committee, AAI Assembly, American Thoracic Society, 2000- Speaker, Post-M.D. fellowship training and academic medicine, National Medical Scientist student forum, Ohio State University, Columbus, OH, 5/2000. Organizing committee, AFMR/CSCR Midwest Meeting, 1999-2000. Organizer and speaker, Macrophage Biology Seminar, International American Thoracic Society Meeting, San Francisco, CA, 5/2001. Chair, AII Planning Committee, 2002- Member, Sarnoff Scientific Board, 2001- NHLBI LBPA Study Section, 2002 Member, Planning committee, Sarnoff Scientific Board, 2002-

Academic Service-Local

Quality Assurance Committee, Ohio State University Medical Center, Department of Internal Medicine, 1989-1996.

4Member, Housestaff Evaluation Committee, Ohio State University Medical Center,


Department of Internal Medicine, 1992-. Member, Intern Recruitment Committee, Ohio State University Medical Center, Department of Internal Medicine, 1994-. Chair, Ethics Committee, Ohio State University Medical Center, Department of Internal Medicine, 1996-2001. Member and Chair, Distinguished Physician Committee, Ohio State University Medical Center, Department of Internal Medicine, Selection Committee, 1997-. Member, Credentials Committee, Ohio State University Medical Center, 1995-. Member, Ethics Taskforce, Ohio State University Medical Center, 1995 Member, Steering Committee and small group discussion leader, Decisions at the End of Life, Ohio State University Medical Center, 1996-1997. Member, Clinical Computing Committee Ohio State University Medical Center, 1995-1997. Chair and Author for Asthma Practice Guideline, Ohio State University Medical Center, 1998. Member, Executive Committee for Quality Management, Ohio State University Medical Center, 1998- Judge, Oral Presentations, Landacre Society for Medical Research, Ohio State University, 1998- Coordinator, Speaker Bureau, Heart and Lung Institute, 1997-. Organizer, HLI Journal Club, Heart and Lung Institute, 1997-. Member, Research Committee, Department of Internal Medicine, 1999-. Co-organizer, Department of Internal Medicine/Heart and Lung Institute, Fellows Research Day, 1999. Member, Intern Selection Committee, Department of Internal Medicine, Ohio State University Medical Center, 1999-. Member, Medical Scientist Training Program Committee, 2000- Organizing committee, Ohio Thoracic Society Annual Conference, 1999- Executive Committee, Ohio Thoracic Society, 2000-. Director, Development Committee, Ohio Thoracic Society, 2000- Member, search committee, Director, Heart and Lung Research Institute, 2000- Chair, search committee, Director, Infectious Diseases, 2000-2001. Co-Chair, search committee, Director, Cardiology, 2001-2002. Organizer, Internal Medicine Fellows Research Day, 2001- Chair, Space Committee, DOIM, 2001- Member, Mentorship Committee, Department of Internal Medicine, 2001 Member, Outcomes Node, Biomedical Research Plan, OSUCMPH, 2001 Deans Research Council, College of Medicine, 2002- BRT Planning Committee Member, College of Medicine, 2002 Salary Recovery Task Force, College of Medicine, 2002 Chair, DMF task force on malpractice, 2002. Featured speaker, White Coat ceremony for incoming medical students, 2002. Steering committee, MSP program, College of Medicine ESIP committee, OSUP, College of Medicine

Grant Support Active Primary Investigator Intracellular Pathways Regulating Monocyte Survival RO-1 HL63800 07/01/00-06/30/05 40% NIH/NHLBI, $1,000,000 total direct A new paradigm for IPF: Monocytes regulate fibrosis through TGF-β RO-1HL 66108 12/27/00-11/30/04 20% NIH/NHLBI, $800,000 total direct

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Clay B. Marsh, Curriculum Vitae NF-κB as an Akt target and regulator of monocyte survival RO-1HL67176 4/1/01-3/31/05 20% NIH/NHLBI, $900,000 total direct Macrophage production and activation of TGF-β by IgG (Marsh, PI Project 2) PO1 HL70294-01 (Orosz PI, PPG) 09/30/2001 - 08/31/2006 20% NIH/NIAID, $5.04 million direct Pathogenesis of IPF Johnie Walker Murphy Career Investigator Award National American Lung Association 07/01/99-06/30/02 $105,000 total direct Pathogenesis of IPF Kelly Clark Memorial Fund 07/01/00-06/30/02 American Lung Association of Ohio $20,000 total direct Marsh, Sponsor - Active Anuj Goyal, AHA Association Fellowship Award 07/01/2000-06/30/03 0% AHA $105,000 Aaron Kirkpatrick, Stanley Sarnoff Foundation 7/01/01-06/30/02 0% Nitin Bhatt, T32 NRSA 07/01/01-06/30/04 0% Naeem Ali, T32 NRSA 07/01/01-06/30/02 Active Co-Investigator 1 P01AI-40150-1 (Wewers) 08/01/96-07/31/02 0% NIH/NIAID and NHLBI $385,335 direct costs RO1 HL62054-01 (Wewers) 9/29/98-9/28/03 0% NIH/NHLBI $229,000 costs/year 1 T32 HL07946-01 (Wewers) 07/01/00 – 06/30/05 NIH/NHLBI Direct costs: $157,215/year Ohio Regional American Heart Association (Crouser), 1999-2001, The role of mitochondria in monocyte survival, $70,000 total. 2R01DK46055-06A2 (Rovin) 2/00-01/04 0% NIH/NIAID $590,228 direct costs Previous Funding

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Clay B. Marsh, Curriculum Vitae American Lung Association Fellowship Award (Marsh), 1991-93, $104,000 total National Institutes of Health National Research Service Award, HL08590, (Marsh), 1992-94, $70,000 total Ohio State University Davis Award (Marsh) 07/01/94 $18,000 American Lung Association of Ohio (Marsh) 07/01/94-06/30/98 $50,000 total

Parker B. Francis Families (Marsh) 07/01/95-06/30/98 $108,000 total Ohio State Univ. Seed Grant (Marsh) 10/01/96-06/30/98 $20,000 total Bremer Foundation (Marsh) 11/01/97-10/31/99 $50,000 total 3MO1RR00034 (Marsh) 07/01/97-06/30/02 NIH/GCRC $587,040 total direct Withdrawn with funding of second RO-1 Gregory Lam, Sarnoff Fellowship (sponsor) 07/01/00-06/30/01 0% Stanley Sarnoff Foundation $23,000 Christine Roos, AHA Fellowship Award (sponsor) 07/01/00-06/30/01 0% AHA $35,000 Patents – Pending

1) Novartis Pharmaceuticals – STI-571 as an anti-inflammatory treatment: activity on reducing monocyte survival.

PUBLICATIONS Refereed Journals 1. Herzyk DJ, Allen JA, Marsh CB, Wewers MD. Macrophage and monocyte IL-1β regulation differs at

multiple sites: messenger RNA expression, translation, and post-translational processing. 1992. The Journal of Immunology 149(9):3052-3057.

2. Marsh CB, Moore SA, Pope HA, Wewers MD. IL-1ra decreases endotoxin-induced IL-1β and TNFα

release from mononuclear phagocytes. 1994. The American Journal of Physiology: Lung Cellular and Molecular Physiology 267:L39-L45.

3. Marsh CB, Pope HA, Wewers MD. Fcγ receptor cross-linking downregulates IL-1ra and induces IL-1β in

mononuclear phagocytes stimulated with endotoxin or Staphylococcus aureus. 1994. The Journal of Immunology 152: 4604-4611.

4. Marsh CB, Wewers MD. Cytokine induced interleukin-1 receptor antagonist release in mononuclear

phagocytes. 1994. American Journal of Lung Molecular and Cellular Biology 10: 521-525. 5. Allen JN, Moore SA, Pope-Harmon AL, Marsh CB, Wewers MD. Immunosuppressive effects of

surfactant and plasma on alveolar macrophages. 1995. Journal of Laboratory and Clinical Medicine 125: 356-369.

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Clay B. Marsh, Curriculum Vitae 6. Marsh CB, Gadek JE, Kindt GC, Moore SA, Wewers MD. Monocyte Fcγ receptor cross-linking induces

IL-8 production. 1995. The Journal of Immunology 155:3161-3167. 7 Pue CA, Mortensen RF, Marsh CB, Pope HA, Wewers MD. Acute phase levels of C-reactive

protein enhance IL-1β and IL-1ra production in by human blood monocytes but inhibit IL-1β and IL-1ra production by alveolar macrophages. 1996. The Journal of Immunology 156:1594-1600.

9. Marsh CB, Anderson CL, Lowe MP, Wewers MD. Monocyte IL-8 release is induced by two independent

FcγR-mediated pathways. 1996. The Journal of Immunology 157:2632-2637. 11. Brown EA, Pope HA, Marsh CB, Wewers MD. LPS enhances type II receptor expression in

dexamethasone treated macrophages: a comparison to IL-1 receptor antagonist. 1997. Cytokine 8(11): 828-836.

12. Marsh CB, Wewers MD, Anderson CL, Tan L, Rovin BH. FcγR cross-linking induces peripheral

blood mononuclear cell MCP-1 expression: role of lymphocyte FcγRIII. 1997. The Journal of Immunology 157:2632-2637.

14. Ralston DR, Marsh CB, Wewers MD. Antineutrophil cytoplasmic antibodies induce monocyte IL-8

release: role of surface proteinase-3, α-1 antitrypsin, and Fcγ receptors. 1997. The Journal of Clinical Investigation 100:1416-1424.

15. Wewers MD, Marsh CB. Role of antibody in the pathogenesis of transplant vascular sclerosis: a

hypothesis. 1997. Transplant Immunology 5:283-288. 16. Marsh CB, Lowe MP, Rovin BH, Parker JM, Liao Z, Knoell DL, Wewers MD. Lymphocytes produce IL-1β

in response to FcγR cross-linking: effects on parenchymal cell IL-8 release. 1998. The Journal of Immunology 160:3942-3948.

17. Marsh CB, Pomerantz RW, Parker JM, Winnard AV, Mazzaferri, Jr. EL, Liao Z, Kelley TW,

Moldovan NC, Beck E, Wewers MD. Regulation of monocyte survival by deposited IgG: role of MCSF. 1999. The Journal of Immunology 162:6217-6225.

18. Kelley TW, Graham MM, Doseff A, Lau SM, Ostrowski MC, Franke TW, Marsh CB. M-CSF

induces monocyte survival through Akt/protein kinase B. 1999. Journal of Biological Chemistry, 274:26393-26398.

19. Rovin BH, Marsh CB. Lymphocytes induce monocyte chemoattractant protein-1 production by

renal cells after Fcγ receptor cross-linking: role of IL-1β. 2001. Journal of Leukocyte Biology 69(3):435-9.

20. Kelley TW, Graham MM, Marsh CB. The role of ROS in monocyte survival and TGF-β

production. 2001. Chest 120(1):15S-16S. 21. Coulter KR, Doseff A, Sweeney P, Wang Y, Marsh CB, Wewers MD, Knoell DL. Opposing

Effect by Cytokines on Fas-Mediated Apoptosis in A549 Lung Epithelial cells. 2002. American Journal of Respiratory Cell Molecular Biology 1;26(1):58-66.

22. Goyal A, Graham MM, Kelley TW, Marsh CB. A common biochemical pathway for monocyte

survival through PI 3-K and Akt/protein kinase B. 2002. American Journal of Respiratory Cell Molecular Biology 26(2):224-30.

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Clay B. Marsh, Curriculum Vitae 23. Tridandapani S, Wang Y, Marsh CB, Anderson, CL. SH2 Domain Containing Inositol

Polyphosphate Phosphatase (SHIP) Regulates NFκB-Mediated Gene Transcription by Phagocytic Fcγ Receptors in Human Myeloid Cells. Journal of Immunology (in press).

24. Kelley TW, Bhatt NY, Lam G, Marsh CB. The role of PI 3-kinase and ROS in Erk activation in M-

CSF-stimulated human monocytes (in revision). 25. Graham MM, Galloway MF, Doseff AI, Nowicki PT, Sen CK, Marsh CB. The presentation of

nitric oxide is critical in promoting monocyte survival and suppressing caspase-3 activation (In revision).

26. Alvarez RJ, Binkley P, Moldovan N, Marsh CB, Kolattukudy P, Goldschmidt PJ. Plaque rupture

and the dead arterial wall hypothesis. (Submitted). 27. Binkley P, Marsh CB, Flavahan N, Kotur M, Wewers MD, Goldschmidt-Clermont. The regulation

of monocyte survival by angiotensin II receptors on human monocytes (Submitted). 28. Lam G, Kelley TW, Khramtsov V, Graham MM, Lau S, Flavahan N, Marsh CB. ROS induced by

M-CSF facilitate monocyte survival: details of molecular targets (Submitted). 29. Tridandapani S, Wang Y, Marsh CB, Anderson CL. SHIP regulates gene expression in

response to FcγR stimulation of THP-1 cells (Submitted). 30. Wang Y, Trindandapani S, McQuown K, Marsh CB. A new paradigm for the activation of

tyrosine kinases by pervanadate (Submitted). 31. Vasudevan SS, Lopes N, Seshiah PN, Wang T, Marsh CB; Kereiakes DJ, Dong C,

Goldschmidt-Clermont PJ. M-CSF- Induced Killing of Smooth Muscle Cells by Monocytes: Role of Monocyte Agglutination and The Fas Death Receptor Pathway (Submitted).

32. Fahy R, McKeegan C, Nuovo GJ, Lichtenberger F, Marsh CB, Wewers MD. Fibroproliferative

Adult Respiratory Distress Syndrome (ARDS): A Role for TGF-β (in revision).

33. Bhatt NY, Kelley TW, Lam G, Marsh CB. The role of adherence in regulating monocyte survival

and differentiation (In preparation). 34. Graham MM, Ho E, Bray T, Marsh CB. The role of NF-κB activation in monocyte survival (In

preparation). 35. Fitzgerald S, Trindandapani S, Malleske D, Marsh CB. Biochemical pathways regulated by Bcr-

Abl to promote cellular activation (in preparation). 36. Lichtenberger F, Frambaugh G, Marsh CB. A novel approach to regulate the biological activity

of TGF-β1 (in preparation). 37. Tridandapani S, Baran C, Wardrop R, Wang Y, Marsh CB. Regulation of FcγR expression and

activity by TGF-β in human monocytes (In preparation).

38. Ali N, Ali N, Lichtenberger F, Bickerstaff A, Flavahan N, Orosz CG, Marsh CB. LAP is 9


Biologically Active and Regulates Inflammation via Interactions with Thrombospondin-1 and CD36 (in preparation).

39. Graham MM, Galloway M, Marsh CB. Monocyte survival to NO donors involves Akt1 activity (in

preparation). 40. Galloway M, Eubank T, Roos C, Marsh CB. M-CSF induces monocytes to release VEGF and

induce angiogenesis (in preparation). 41. Kirkpatrick A, Wang Y, Baran C, Trindandapani S, Marsh CB. HSP90 regulates monocyte

survival through the recruitment of Hck (in preparation).

Refereed journals (Clinical) 1. George D, Marsh CB, Leier CV. The A wave liver. 1988. Clinical Cardiology 11:349-350. 2. Marsh CB, Trudeau M, Weiland JE. Resistant asthma in a 32-year-old woman. 1994. Chest

105: 1855-1857. 3. Knoell DL, Marsh CB. Vocal Cord Dysfunction Presenting as Steroid-Dependent Asthma. 1997.

Journal of Pharmacy Technology 13:118-121. 4. Knoell DL, Pierson JF, Marsh CB, Allen JN, Pathak DS. 1998. Measurement of outcomes in adult

patients receiving pharmaceutical care in a comprehensive asthma clinic. Pharmacotherapy 18:1365-1374.

Books and Book Chapters

1. Marsh CB, Mazzaferri E. General Internal Medicine Pearls, Hanley and Belfus, S. Sahn, J. Heffner, eds., 1993.

2. Wewers MD, Gadek JE, Marsh CB. Proinflammatory polypeptides. In: THE LUNG: Scientific Foundations, 2nd Edition. 1996. Crystal RG and West JB, Eds., Lippencott-Raven Publishers, 117-132.

3. Marsh CB, Wewers, MD. Immunopathogenesis of sepsis. 1996. Clinics in Chest Medicine, P. Dorinsky, Ed., 17(2):183-197.

Practice Guidelines (copyrighted) Asthma Guidelines (1999, 2001) OSU University Hospitals Patents – initial application

1) STI-571 as an anti-inflammatory (pending) with Novartis 2) LAP as a biologically active molecule (submitted) 3) HSP90 as a molecular target in inflammation (submitted)

Non-Refereed Journals

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Clay B. Marsh, Curriculum Vitae 1. Marsh CB, Mazzaferri EM. Shoulder and back pain with early morning stiffness in an elderly

woman. 1994. Hospital Practice 29(8): 39. 2. Marsh CB, Mazzaferri EM. Fever and diarrhea in a male college student. 1994. Hospital

Practice. 29(9): 56. 3. Marsh CB, Mazzaferri EM. Nephrotic syndrome, shoulder pain, and dyspnea in a persistent

cougher. 1994. Hospital Practice 29(10): 70. 4. Marsh CB, Mazzaferri EM. Exertional dyspnea in a young woman. 1994. Hospital Practice

29(11): 52. 5. Marsh CB, Mazzaferri EM. Syncope in a middle-aged man at work. 1995. Hospital Practice

30(3): 52. Abstracts 1. Marsh CB, Wewers, MD. Interleukin-1α induced interleukin-1β and tumor necrosis factor-α

and inhibition by interleukin-1 receptor antagonist. 1992. American Review of Respiratory Diseases 145:270A.

2. Marsh CB, Wewers MD. Interleukin-1 receptor antagonist inhibits lipopolysaccharide-induced

monocyte interleukin-1β and tumor necrosis factor-α production. 1992. Clinical Research 40:327A.

3. Marsh CB, Wewers MD. The effect of cytokines on IL-1 receptor antagonist release. 1993.

American Review of Respiratory Diseases 147: 231A. 4. Marsh CB, Wewers MD. Immobilized interleukin-1α induces interleukin-1 receptor antagonist

but not interleukin-1β. 1993. Clinical Research 41:372A. 5. Marsh CB, Wewers MD. Fcγ receptor (FcγR) Cross linking with LPS or heat killed staph

aureus (HKSA) causes divergence of IL-1β and IL-1ra production. 1993. Clinical Research 41:688A.

6. Allen JN, Marsh CB, Moore SA, Wewers MD. Surfactant and plasma exert

immunosuppressive effects on alveolar macrophage cytokine production. 1993. Clinical Research 41:689A.

7. Marsh CB, Wewers MD. Maturation changes Fcγ receptor-mediated IL-1β responses. 1994.

American Journal of Respiratory and Critical Care Medicine A1099. 8. Marsh CB, Anderson CL, Wewers MD. FcγRII Cross-linking induces interleukin-1 receptor

antagonist. 1994. The Journal of Physiology 9. Marsh CB, Wewers MD. Human Fcγ receptor II (FcγRII) regulates interleukin-1 receptor

antagonist (IL-1ra) production. 1994. Clinical Research 42:397A. 10. Marsh CB, Wewers MD. Blood leukocyte interleukin-8 (IL-8) production. 1995. FASEB J.

9:A246.

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Clay B. Marsh, Curriculum Vitae 11. Marsh CB, Gadek JE, Wewers MD. Monocyte Fcγ receptor III regulates IL-8. 1995. American

Journal of Respiratory and Critical Care Medicine 264A. 12. Marsh CB, Anderson CL, Gadek JE, Wewers MD. Lymphocyte FcγR Cross- linking induces a

factor that induces IL-8 in monocytes. 1995.Cytokine. 620. 13. Ralston DR, Marsh CB, Lowe MP, Wewers MD. Antineutrophil cytoplasmic antibodies induce

proteinase-3-expressing monocytes to release IL-8. 1996. American Journal of Respiratory and Critical Care Medicine 153:A287.

14. Marsh CB, Anderson CL, Wewers MD. Monocyte IL-8 is directly induced by FcγRI and

indirectly by a soluble FcγRIII-stimulated lymphocyte factor. 1996. American Journal of Respiratory and Critical Care Medicine 153:A415.

15. Knoell DL, Marsh CB, Wewers MD. Delivery of the type II interleukin-1 receptor cDNA

inhibits interleukin-8 production in human fibroblasts. 1996. FASEB J 10:A1331. 16. Marsh CB, Wewers MD, Tan LC, Rovin BH. PBMC and monocytes release MCP-1 in

response to FcγR cross-linking. 1996. FASEB J. 10:A1343. 17. Rovin BH, Tan LC, Wewers MD, Marsh CB. Leukocyte Fcγ receptor (FcγR) cross-linking induces

monocyte MCP-1: a model for immune complex (IC)-mediated monocyte recruitment. 1996. Journal of the American Society of Nephrology 7:A1718.

18. Knoell DL., Pierson JF., Pathak D., Allen JA., Marsh CB. Pharmacist

Interventions in a comprehensive asthma clinic. 1996. American Journal of Health-Systems Pharmacist 31:P-556R.

19. Marsh CB, Winnard AV, Mazzaferri EL, Jr., Beck E, Wewers MD. Immune complexes induce

monocyte maturation through MCSF production. 1997. American Journal of Respiratory and Critical Care Medicine 155:A682.

20. Marsh CB, Lowe MP, Rovin BH, Knoell DL, Wewers MD. An FcγR-mediated pathway leads to

parenchymal cell IL-8 release. 1997. American Journal of Respiratory and Critical Care Medicine 155:A540.

21. Rovin BH, Danne M, Wewers MD, Marsh CB. Lymphocyte FcγR cross-linking mediated

human renal cell MCP-1 production through an IL-1β-mediated pathway. (Submitted) 22. Marsh CB, Parker JM, Coggeshall KM, Wewers MD. Macrophage colony stimulating factor

protects monocytes from apoptosis through a PTK- and PI-3-K-mediated pathway. Journal of Investigative Medicine 45(7):302A.

23. Fahy RJ, Winnard AV, Liao Z, Marsh CB, Wewers MD. Effect of caspase inhibitors on

monocyte apoptosis. Journal of Investigative Medicine 45(7):298A. 24. Marsh CB, Parker JM, Wewers MD. MCSF protects monocytes from apoptosis through a PI 3-K- and

oxidant-mediated pathway. 1998. American Journal of Respiratory and Critical Care Medicine 157:A455.

25. Fahy RJ, Winnard A, Liao J, Marsh CB, Wewers MD. The role of caspases in monocyte apoptosis.

1998. American Journal of Respiratory and Critical Care Medicine157:A238.

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Clay B. Marsh, Curriculum Vitae 26. Archer TP, Goldschmidt PJ, Marsh CB, Moldovan NI. Direct in vitro cytotoxic effect of adherent

monocytes on aortic smooth muscle cells. 27. Marsh CB, Kelley TW, Graham MM, Pomerantz RW, Wewers MD. Molecular mechanisms of

monocyte survival. Journal of Investigative Medicine 1998. 28. Marsh CB, Kelley TW, Graham MM, Wewers MD. The role of oxidants in monocyte survival.

1999. FASEB J 13:A1014. 29. Marsh CB, Graham MM, Kelley TW. The role of Akt in monocyte survival. The Journal of

Investigative Medicine 1999. 30. Bhatt NY, Kelley TW, Graham MM, Marsh CB. A novel pathway of regulating monocyte survival:

SHP-1 binds to PI 3-kinase after M-CSF stimulation. American Journal of Respiratory and Critical Care Medicine, 161: A454, 2000.

31. Marsh CB, Kelley TW, Graham MM. The role of reactive oxygen species and reactive nitrogen

species in M-CSF-induced monocyte survival. American Journal of Respiratory and Critical Care Medicine, 161: A513, 2000.

32. Goyal A, Graham MM, Crouser ED, Marsh CB. Inflammatory cytokines induce monocyte survival

via activation of phosphatidylinositol 3-kinase (PI 3-K) complex. American Journal of Respiratory and Critical Care Medicine, 161: A900, 2000.

33. MF Galloway, WJ Waldman, CB Marsh. Macrophage-Colony Stimulating Factor, MCSF, stimulates

VEGF production in human monocytes. FASEB Journal, 16(4): A1849. 2002 Invited Presentations – National 1. Interleukin-1 receptor antagonist inhibits lipopolysaccharide-induced monocyte interleukin-1β and

tumor necrosis factor-α production. American Federation for Clinical Research National Meeting, Baltimore, MD 4/92.

2. The use of adjuvant therapies for the treatment of bronchogenic lung cancer. Sunrise session

at the American Thoracic Society International Conference, Miami, FL, 5/92. 3. Interleukin-1α induced interleukin-1β and tumor necrosis factor-α and inhibition by interleukin-1

receptor antagonist. American Thoracic Society International Conference Miami, FL, 5/92. 4. The effect of cytokines on IL-1 receptor antagonist release. American Thoracic Society International

Conference, Boston, MA, 5/93. 5. Fcγ receptor (FcγR) Cross linking with LPS or heat killed staph aureus (HKSA) causes divergence of

IL-1β and IL-1ra production. American Federation for Clinical Research Midwest Meeting Chicago, IL, 11/93.

6. FcγRII cross-linking induces interleukin-1 receptor antagonist. American Society of

Physiology National Meeting, Yale University, 3/94. 9. Human Fcγ receptor II (FcγRII) regulates interleukin-1 receptor antagonist (IL-1ra) production.

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American Federation for Clinical Research Midwest Meeting, Chicago, IL, 9/94. 10. Blood leukocyte interleukin-8 production. Experimental Biology International Meeting, Atlanta, GA,

4/95. 11. Monocyte FcγRIII cross-linking induces IL-8 release. American Thoracic Society International Meeting,

Seattle, WA, 5/95. 12. Lymphocyte Fcγ receptor cross-linking induces a factor that stimulates monocyte IL-8 release.

International Cytokine Society Meeting, Harrogate, UK, 9/95. 13. Monocyte IL-8 is directly induced by FcγRI and indirectly by a soluble FcγRIII-stimulated

lymphocyte factor. American Thoracic Society International Meeting, New Orleans, LA, 1996. 14. Antineutrophil cytoplasmic antibodies induce proteinase-3-expressing monocytes to release

IL-8, American Thoracic Society International Meeting, New Orleans, LA, 1996. 15. Monocyte FcγR cross-linking protects monocytes from apoptosis, American Thoracic Society

International Meeting, San Francisco, CA, 1997. 16. Macrophage colony stimulating factor protects monocytes from apoptosis through a PTK and

PI-3-K-mediated pathway. American Federation for Medical Research Meeting, Chicago, IL, 1997.

17. MCSF protects monocytes from apoptosis through a PI 3-K- and oxidant-mediated pathway.

American Thoracic Society International Meeting, Chicago, IL, 1998. 18. Molecular mechanisms of monocyte survival. Midwest section, AFMR meeting, Chicago, IL

1998. 19. American College of Clinical Pharmacology, National Meeting, Basic Mechanisms of

Inflammation, Cincinnati, OH 11/98. 20. The role of monocyte survival in the genesis of IPF. 1st Johnie Walker Murphy Symposium on

Interstitial Lung Disease, El Dorado, AR, 1999. 21. The role of oxidants in monocyte survival. FASEB International Conference, Washington,

D.C., 4/99. 22. Molecular pathways of monocyte survival and apoptosis, American Thoracic Society

Symposium on Apoptosis, ATS International Meeting, San Diego, CA 4/99. 23. The role of Akt in monocyte survival. Midwest AFMR meeting, Chicago, IL 9/99. 24. Organizer and moderator, Research symposium, Midwest Section, AFMR, Chicago, IL 9/99. 25. The role of reactive nitrogen species in M-CSF-induced monocyte survival. American

Thoracic Society International Meeting, Toronto, CA, 5/2000. 26. Monocyte survival factors induce monocyte survival and induce the secretion of factors that

activate latent TGF-β: The role of reactive oxygen species and Erk, 43rd Annual Tom Petty Lung Conference, Aspen, CO, 6/2000.

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Clay B. Marsh, Curriculum Vitae 27. Life and Death Decisions: How the monocyte can cause human disease. University of Iowa.

8/2000. 28. Biology of alveolar macrophages, organizer and speaker, ATS International Conference,

5/01. 29. Macrophages: Eat to live and live to eat, co-chair and featured speaker, minisymposium, ATS

International Conference, 5/02. 30. The biological regulation of SHIP in monocyte activation with M-CSF. Duke University,

4/2002. Invited Presentations – Local 1) Internal Medicine Grand Rounds, Ohio State University, Apoptosis: Good News or Bad? 1998. 2) Update on pulmonary thromboembolic disease. Pulmonary and Critical Care Review Course,

Columbus, OH, 2/1998. 3) Update on interstitial lung disease, Pulmonary and Critical Care Review Course, Columbus, OH,

2/1999. 4) Monocyte survival and human diseases: the next Akt. Internal Medicine Grand Rounds,

Columbus, OH, 1999. 5) Update on new practices in the treatment of patients with asthma, Grand Rounds, Ohio State

University East, 1999. 6) Update on community-acquired pneumonias. Pulmonary and Critical Care Review Course,

Columbus, OH, 2/2000. 7) Internal Medicine Grand Rounds, Ohio State University, Update on idiopathic pulmonary fibrosis

(combined presentation with Dr James Allen) 7/2000. 8) Molecular Virology, Immunology and Human Genetics seminar, Ohio State University, The

biochemical details of monocyte survival and differentiation: Roles in health and disease, 8/2000.

9) Internal Medicine Grand Rounds, Ohio State University. Academic Medicine: road to the

future (combined presentation with Mike Grever and Karla Zadnik). 8/2000. 10) Landacre Dinner Presentation, Ohio State University, Life and death of the monocyte and

impact on human disease. 9/2000. 11) Department of Physiology and Cellular Biology, Ohio State University. Details of intracellular

mechanisms of monocyte survival and differentiation. 10/2000. 12) Immunology Conference, Ohio State University. Life, Death and Differentiation of monocytes.

10/2000. 13) Update on asthma – Medical Therapeutics Course, 3/2001. 15


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14) Molecular Therapeutics Group – Life and death decisions of monocytes – implications for cancer and inflammation, 3/2001.

15) Heart and Lung Research Institute – Regulation of monocyte survival by nitric oxide, 3/2001. 16) Internal Medicine Grand Rounds – Monocyte survival in heart and lung disease: too much of a

good thing, 5/2001. 17) Veterinary Biosciences Seminar Series – The role of monocytes in regulating fibrosis in the

lung: implications for treatment of IPF, 9/2001. 18) Internal Medicine Grand Rounds. Discussant unknown case of SLE/anti-phospholipid

antibody syndrome, 11/2001.

Documents

CURRICULUM VITAE CLAY BRADEN MARSH, M.D. - … Harrold Rotation 5/02 Microarray analysis in murine lungs Internal Medicine Resident Pamela Habib Undergrad Student 7/01/02