CURRICULUM VITAE Anne M. Lynch, MB, BCh, BAO, … · 1983 Diploma in Obstetrics (DObst), ... 2010 Assistant Professor, Preventive Medicine and Biometrics, Department of ... Seminar,

Anne Lynch, MD, MSPH Last revised October 11, 2017 Page 1 of 36

CURRICULUM VITAE

Anne M. Lynch, MB, BCh, BAO, MSPH, DCH, DObst.

PERSONAL HISTORY

Full Name: Anne Mary Lynch (née Keane)

Associate Professor

Director, Division of Ophthalmic Epidemiology

Department of Ophthalmology

University of Colorado School of Medicine

1675 Aurora Court, F731, Aurora, CO 80045

Secondary Appointment: Department of Epidemiology

Colorado School of Public Health

Administration: (720) 848-2500

EDUCATION

1979 Medical degree (MB, BCh, BAO) University College Dublin, Ireland, Medical

School

1980 Diploma in Child Health (DCH), National University of Ireland

1983 Diploma in Obstetrics (DObst), Royal College of Physicians, Ireland

1998 Master of Science in Public Health, University of Colorado Health Sciences Center

(HSC), Denver, CO

Internship

1979 – 1980 Medicine and Surgery, Mater Misericordiae University Hospital, Dublin, Ireland

Residencies

1980-1983 Pediatrics: Our Lady's Hospital for Sick Children, Dublin, Ireland

Medicine: Endocrinology and Diabetes, Mater Misericordiae University Hospital,

Dublin, Ireland

Obstetrics & Gynecology: Coombe Women & Infants University Hospital Dublin

Geriatric Medicine: St. Laurence's Hospital, Dublin, Ireland

Psychiatry: Mater Misericordiae University Hospital, Dublin, St. Vincent’s

Psychiatric Hospital, Fairview, Dublin, Ireland


Rheumatology Fellowships 1984-1986 Clinical Fellow, Department of Rheumatology, Mater Misericordiae University

Hospital, Dublin, Ireland

1987-1989 Career Break

1989-1993 Research Fellow, Division of Rheumatology, University of Colorado Health

Sciences Center, Denver, CO

Master of Science in Public Health 1994-1998 Master of Science in Public Health Program, University of Colorado Health

Sciences Center, Denver, CO

ACADEMIC APPOINTMENTS

2002 – 2004 Senior Clinical Instructor, Department of Obstetrics and Gynecology,

University of Colorado School of Medicine, Aurora, CO

2004 – 2010 Assistant Professor, Department of Obstetrics and Gynecology, University of

Colorado School of Medicine, Aurora, CO

2005 – 2010 Assistant Professor, Preventive Medicine and Biometrics, Department of

Epidemiology, Colorado School of Public Health, Aurora, CO

2010 – 2013 Associate Professor, Department of Obstetrics and Gynecology, University of


2010 – Associate Professor, Preventive Medicine and Biometrics, Department of

Epidemiology, Colorado School of Public Health, Aurora, CO

2014 – Associate Professor, Department of Ophthalmology, University of Colorado

School of Medicine, Aurora, CO

PROFESSIONAL EXPERIENCE

1994 – 1998 Teaching Assistant, Introductory and Advanced Epidemiology courses, MSPH

program

1999 – 2003 Epidemiologist/Research Analyst, Department of Research and Development,

Kaiser Permanente, Denver, CO

2000 – 2002 Senior Professional Research Assistant, Radiology-Diagnostics, University of


2006 – 2010 K-23 Mentored Patient-Oriented Research Career Development Award, Eunice

Kennedy Shriver National Institute of Child Health and Human Development

(NIH/NICHD). Training in perinatal epidemiology and reproductive immunology.


Department of Obstetrics and Gynecology, University of Colorado School of

Medicine, Aurora, CO

2014 – Director, Division of Ophthalmic Epidemiology, Department of Ophthalmology,

University of Colorado School of Medicine, Aurora, CO

HONORS, SPECIAL RECOGNITIONS AND AWARDS

2002 Roy M. Pitkin Award, American Congress of Obstetricians and Gynecologists,

for the manuscript: “Preeclampsia in multiple gestation: the role of assisted

reproductive technologies”

2006 K-23, Mentored Patient-Oriented Research Career Development Award, NICHD

2007 Junior Faculty Research Development Award, List Family Foundation Center for

Women’s Health Research, for the project “Antiangiogenic Factors, Complement

Activation Fragment Bb and Preeclampsia”

2012 – 2013 Participant and graduate, Leadership in Innovative Team Science (LITeS)

program, Colorado Clinical and Translational Sciences Institute (CCTSI),

University of Colorado Denver

2012 – 2015 Member, Obstetrics and Maternal-Fetal Biology (OMFB) study section, NICHD

2013 Member, Maternal-Fetal Medicine Meta-analysis group, NICHD

2016 Invited Speaker, TED talk, Childx Symposium, Stanford University, Palo Alto, CA

2017 Best Poster Award, American Association for Pediatric Ophthalmology and

Strabismus (AAPOS) annual meeting

MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS

2007 – 2013 Society for Pediatric and Perinatal Epidemiologic Research (SPER)

2015 – American Academy of Ophthalmology (AAO)

2015 – Association for Research in Vision and Ophthalmology (ARVO)

MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES

National

2011 – 2014 Member, Obstetrics and Maternal-Fetal Biology (OMFB) study section, NICHD


2013 Member, Maternal-Fetal Medicine Meta-analysis group, NICHD

2012 Member, Adverse Events Committee, Effects of Aspirin in Gestation and

Reproduction (EAGeR) trial, NICHD

University of Colorado

2004 – 2005 Clinical Translational Research Advisory Committee (CTRAC)

2005 – 2012 Chair, Colorado Complement Research group

2007 – Faculty Member, Center for Women’s Health Research (CWHR)

2007 – Thesis Mentor, MSPH/MPH Candidates, Colorado School of Public Health

2010 – 2013 Chair, Triage and Perinatal Research Facilitation Committee

2010 – 2013 Co-Director, Child and Maternal Health (CMH) Research Program, Colorado

Clinical and Translational Sciences Institute (CCTSI)

2012 – 2015 Scientific Research Committee, Colorado Multiple Institutional Review Board

(COMIRB)

2010 – Planning and Oversight Committee, Child and Maternal Health (CMH) Research

Program, CCTSI

2015 – Dean’s Advisory Committee

Departmental

2004 – 2013 Director, Perinatal Database, Department of Ob/Gyn

2011 – 2013 Director, Colorado Baby Blanket Research Program

2011 – 2013 Member, Department of Ob/Gyn AEF committee

2012 – 2013 Chair, Search Committee for the Maternal Fetal Medicine Chief and PI of the

Maternal Fetal Medicine Unit (MFMU)

2014 – Director, Division of Ophthalmic Epidemiology, Department of Ophthalmology,

with responsibilities for building databases, mentoring and grant applications

2014 – Director and Founder, Interdisciplinary Colorado Retinopathy of Prematurity

Research Group (CO-ROP)

2014 – Director and Founder, Cataract Outcomes Oversight

2014 – Director and Founder, Age-related Macular Degeneration (AMD) Registry

oversight committee

2014 – Director and Founder, Retina Research Group

2015 – Director and Founder, AMD/ROP biomarker research program


Community

2009 – 2012 Chair, Perinatal Epidemiology “Starbucks” Research Mentoring Group

2010 – 2012 Member, March of Dimes State Program Services Committee

2010 – 2013 Co-Chair, Healthy Women Healthy Babies

REVIEW AND REFEREE WORK

Reviewer

2007 – 2013 Abstract Reviewer, Society for Pediatric and Perinatal Epidemiologic Research

(SPER) annual meeting

2010 Ad Hoc Reviewer, NIH Challenge Grants in Health and Science Research,

Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrated

Review Group (EMNR IRG), NIH Center for Scientific Review

2011 – 2014 Member, Obstetrics and Maternal-Fetal Biology (OMFB) study section, Eunice

Kennedy Shriver National Institute of Child Health (NICHD) and Human

Development

2012 – 2013 Publications Committee, Maternal Fetal Medicine Unit (MFMU)

Editorial Services to Scholarly Publications

– American Journal of Obstetrics and Gynecology

– British Medical Journal

– Clinical and Experimental Immunology

– European Journal of Obstetrics and Gynecology

– Journal of Rheumatology

– Molecular Human Reproduction

– Paediatric and Perinatal Epidemiology

INVITED LECTURES AND PRESENTATIONS

Extramural

1. The Complement System, Obesity, and the Colorado Baby Blanket Perinatal Research

Program. Diabetes and Pregnancy Study Group – West: Moving the Maternal-Pediatric

Paradigm Forward, Denver, CO. May 13, 2011.

2. IRB Review of Research involving pregnant women: Biomedical case studies. Association

for the Accreditation of Human Research Protection Programs annual conference on

Protecting Vulnerable Participants, Denver, CO. April 20, 2012

3. Activities and Role of the Perinatal Research Facilitation Core at the AMC. 5th Annual

Clinical Research Management Workshop, Yale University. New Haven, CT. June, 2012.


4. Databases: New and Existing. SMFM Fellows’ Research Lecture Series,

https://www.smfm.org/fellowship/lectures/76-databases. November 21, 2012.

5. Novel approaches to biomarker discovery for preterm birth and retinopathy of prematurity.

Childx meeting, Stanford University Symposium. Enduring material at

http://childx.stanford.edu/video/2016-conference/anne-lynch-development-term. See also

(Lynch Preterm Birth interview). Palo Alto, CA. April 21, 2016.

Intramural, CUSOM

1. Complement activation and adverse pregnancy outcomes. Basic Reproductive Sciences

Seminar, 2006

2. Technology Approaches to Gender Specific Diseases. Fall Forum, 2006

3. Challenges in Clinical Study Design and Data Management. Women’s Health

Investigators Network, 2006

4. Critical review of the literature. Medical Student Lecture, 2007

5. Complement Split products and intrauterine loss. Department of Obstetrics and

Gynecology Grand Rounds, 2007

6. Complement activation and adverse pregnancy outcomes. National Jewish Medical and

Research Center Complement Laboratory, 2007

7. Complement activation and adverse pregnancy outcomes. Newborn Hope, Colorado

Springs, 2007


Seminar, 2007

9. Complement activation and adverse pregnancy outcomes. Perinatal Research Conference,

2008

10. Bringing Bench Laboratory Results to the Bedside: The Denver Complement Study.

Department of Obstetrics and Gynecology 60th Anniversary, 2008

11. A Study of the Contribution of Immune and Vascular Factors to High Blood Pressure in

Pregnancy. Center for Women’s Health Research, 2008


Seminar, 2008

13. The Denver EAGeR trial. Perinatal Plus Advisory Committee Meeting, Colorado

Department of Public Health and Environment, 2009

14. Intrauterine loss & the EAGeR trial. Rose Medical Center Grand Rounds, 2009

15. The Denver EAGeR trial. Kaiser Permanente Grand Rounds, 2009

16. Hypertensive Disease in Pregnancy as a Predictor of Cardiovascular Disease Later in

Life. 7th Annual Colorado Women’s Cardiovascular Health Symposium, 2009

https://www.smfm.org/fellowship/lectures/76-databases

http://childx.stanford.edu/video/2016-conference/anne-lynch-development-term

http://childx.stanford.edu/video/2016-conference/anne-lynch


17. Social media and the EAGeR Trial. Program in Reproductive Science Seminar, Dept.

OB/GYN, 2009

18. Critical review of the literature. Medical Student Lecture, 2009

19. Complement in Obesity, Cardiovascular Disease and Pregnancy Complications. Taligen

Therapeutics, 2010

20. Perinatal Research at UCH. Leadership Forum, University of Colorado Hospital, 2010

21. Colorado Baby Blanket Perinatal Research Program. MFM Research Meeting, 2010

22. Introduction to the Colorado Baby Blanket Research Program. Perinatal Research

Conference, 2010

23. Colorado Baby Blanket Perinatal Research Program. External Advisory Committee

Meeting, Colorado Clinical and Translational Sciences Institute, 2011

24. Colorado Baby Blanket Perinatal Research Program. Program in Reproductive Science

Seminar, Dept. OB/GYN, 2011

25. Colorado Baby Blanket Perinatal Research Program. Child Maternal Health Program,

2011

26. Colorado Baby Blanket Perinatal Research Program. Nuts and Bolts, Colorado Clinical

and Translational Sciences Institute, 2011

27. Colorado Baby Blanket Perinatal Research Facilitation Program. Child Maternal Health

Program Oversight Committee, 2012

28. Baby Blanket. Summer Lecture Series, OB/GYN grand rounds, 2012

29. HEED mini retreat, Department of Ophthalmology, 2014

30. Development of a research infrastructure for Ophthalmic Epidemiology research. 18th

Annual Ophthalmology Symposium, 2014

31. Molecular Epidemiology of Preterm Birth - Novel Approaches. Frontiers in Pregnancy

Research Symposium, University of Colorado School of Medicine, 2015



Other, CUSOM

1. Moderator, Parturition and Premature Birth, Frontiers in Pregnancy Research

Symposium, 2011

2. Judge, poster session, Research Day, Center for Women’s Health Research, 2011

3. Judge, Poster session, Research Day, Center for Women’s Health Research, 2012

4. Judge, Poster session, Research Day, Center for Women’s Health Research, 2013


TEACHING RECORD

2004 – 2013 Leadership of a mentoring program in the Dept. Obstetrics and Gynecology

2004 – Mentor for medical students CUSOM

2005 – Mentor in the Colorado School of Public Health - MPH graduate students

2015 – Development and leadership of a mentoring program in the Division of

Ophthalmic Epidemiology

Summary of Mentoring and Facilitation of Research

2004 – Mentor for 7 medical students, 17 residents, 13 fellows, 8 MSPH/MPH

students, 20 junior faculty and 9 other faculty, in the Departments of Obstetrics

and Gynecology, Ophthalmology, Pediatrics, Pathology, Colorado School of

Public Health, and other departments across campus, resulting in 90

presentations, 27 published papers

Mentees

A. Department of Obstetrics and Gynecology (2004-2013)

1. Lorraine Dugoff MD, Professor, Department of Ob/Gyn, Hospital of the University of

Pennsylvania, Philadelphia, PA

2. William Schlaff MD, Professor and Chair, Department of Ob/Gyn, Reproductive

Endocrinology & Infertility, Thomas Jefferson University, Philadelphia, PA

3. Kian Behbakht MD, Professor, Gynecologic Oncology, Department of Ob/Gyn,

CUSOM

4. Gretchen Heinrichs MD, DTMH, Associate Professor, Department of Ob/Gyn,

CUSOM and Professor of Ob/Gyn, DHMC

5. Rory Moore MD, Obstetrician-gynecologist, Kaiser Permanente, Denver CO

6. Bronwen Kahn MD, Maternal and Fetal Medicine, Obstetrix Medical Group of

Colorado

7. Kimberly Roos MD, FACOG, Obstetrician-gynecologist, St. Francis Healthcare

System, Cape Girardeau, MO

8. Torri Metz MD, MSCI, Assistant Professor, Maternal Fetal Medicine, Department of

Ob/Gyn, and WRHR Scholar in the Division of Reproductive Sciences, CUSOM

9. Elizabeth Brass MD, Assistant Professor, Department of Ob/Gyn, Oregon Health

Sciences

10. Anusha Streubel MD, MPH, Neonatal-Perinatal Medicine, Aurora, CO

11. Lindsay Eun MD, Obstetrician-gynecologist in Arvada, CO, affiliated with Exempla

Lutheran Medical Center

12. Chesney Thompson MD, Professor and Vice Chair, Department of Ob/Gyn, CUSOM

13. Camille Hoffman MD, Assistant Professor, Maternal Fetal Medicine, Departments of

Ob/Gyn and Psychiatry, CUSOM


14. Barbra Fisher MD, PhD, Maternal and Fetal Medicine, Providence Health and Services

Oregon and Southwest Washington

15. Pia Hauk MD, Associate Professor, Pediatrics, National Jewish Health

16. Todd Lovgren MD, Perinatology, Maternal-Fetal Medicine, Methodist for Women,

Elkhorn, NE

17. Mirjam (Mimi) Kunze MD, Faculty member, Ob/Gyn, University Medical Center

Freiburg, Germany

18. Jennifer Lindhorst MD, Mile High Ob/Gyn, affiliated with Rose Medical Center,

Denver CO

19. Nicholas (Nick) Behrendt MD, Assistant Professor, Maternal Fetal Medicine,

Department of Ob/Gyn, CUSOM

20. Meghan Donnelly MD, Assistant Professor, Maternal Fetal Medicine, Department of

Ob/Gyn, CUSOM

21. Jinny Lavezzi, DO, MPH, Neonatology/Perinatology, Kansas City, MO

22. Nancy West PhD, Assistant Professor, Biostatistics, University of Mississippi Medical

Center, Jackson, MS

23. Gaea Moore MD, MS, Kaiser Permanente, Maternal Fetal Medicine, Department of

Ob/Gyn, Oakland CA

24. Elizabeth Greenwell ScD, Assistant Professor, Community and Behavioral Health,

CSPH

25. Laxmi Kondapalli MD, Colorado Center for Reproductive Medicine

26. Jennifer Armstrong Wells MD, Associate Professor, Department of Pediatrics,

Children’s Hospital Colorado

27. Maya Bunik MD, Associate Professor, Department of Pediatrics, Children’s Hospital

Colorado

28. Virginia Winn MD PhD, Associate Professor, Researcher, and Obstetrician

Gynecologist (MFM) at Stanford University, CA

B. Department of Ophthalmology

29. Emily McCourt, MD, Associate Professor, Pediatric Ophthalmology and Adult

Strabismus, Department of Ophthalmology, CUSOM

30. Jennifer Cao, MD, Assistant Professor, Dept. Ophthalmology, UT Southwestern

31. Amy Cherof, MD, Marietta Eye Clinic, Georgia

32. Michael Wildes, MD, Resident, Department of Ophthalmology, CUSOM

33. Gabriela Rodriguez-Colon, MD, Graystone Ophthalmology Associates, Hickory, NC

34. Niranjan Manoharan, MD, Resident, Department of Ophthalmology, CUSOM

35. Kirstin Tawse, MD, Front Range Eye Physicians, Longmont, CO

36. Jamie Alexander, MD, Cornea Associates of Texas


37. Rebecca Sands Braverman, MD, Associate Professor, Pediatric Ophthalmology and

Adult Strabismus, Department of Ophthalmology, CUSOM

38. Levi Bonnell, MPH, Geospatial Analyst, General Internal Medicine Research,

Department of Medicine, University of Vermont, Burlington, VT

39. Jennifer Jung, MD, Assistant Professor, Pediatric Ophthalmology and Adult

Strabismus, Department of Ophthalmology, CUSOM

40. Erica Wymore, MD, Assistant Professor, Neonatology, Dept. of Pediatrics, CUSOM

41. Jasleen Singh, MD, Assistant Professor, Pediatric Ophthalmology and Adult Strabismus,

Department of Ophthalmology, CUSOM

42. Frank Siringo, OD, MD, Assistant Professor, Vitreoretinal Diseases and Surgery,


43. Scott Oliver MD, Associate Professor, Vitreoretinal Diseases and Surgery, Department

of Ophthalmology, CUSOM

44. Jennifer Hodges MD, PhD, Assistant Professor, Maternal and Fetal Medicine,

Department of Ob/Gyn, CUSOM

45. Alaa Bou Ghannam MD, Clinical Instructor, pediatric ophthalmology and neuro-

ophthalmology, Department of Ophthalmology, American University of Beirut, Lebanon

46. Ronald Wise MD, Assistant Professor, Department of Ophthalmology, CUSOM

47. Steven Petty MD, Clinical Faculty, Department of Ophthalmology, CUSOM

48. Ram Nagaraj PhD, Professor, Department of Ophthalmology, CUSOM

49. Cara Capitena Young MD, Glaucoma fellow, Department of Ophthalmology, CUSOM

50. Garrison Weir MD, Resident, Department of Ophthalmology, CUSOM

51. Gabriel Lazcano Gómez MD, Faculty, Médico Adscrito al Servicio de Glaucoma,

Asociación para Evitar la Ceguera en México (APEC)

52. Amber Berning MD, Assistant Professor, Department of Pathology, CUSOM

53. Paula Pecen MD, Assistant Professor, Uveitis and Vitreoretinal Diseases and Surgery,


54. Elizabeth Echalier MD, Resident, Department of Ophthalmology, CUSOM

55. Ashlee Cerda MPH, Healthcare Data Analyst, Colorado Community Managed Care

Network

56. Mariam Ahmad MD, Fellow, Pediatric Ophthalmology and Adult Strabismus,


57. Greg Brunin MD, Rashid, Rice, Flynn & Reilly Eye Associates, San Antonio, TX

58. Leonard Seibold MD, Associate Professor, Department of Ophthalmology, CUSOM

59. Tori Miller MD, Resident, Department of Ophthalmology, CUSOM

60. Taylor Slingsby MD, Resident, Department of Ophthalmology, CUSOM


C. Mentorship provided to graduate students in the Colorado School of Public Health

61. Erin Hirsch MPH, Research Coordinator, Cancer Center, University of Colorado

62. Beena Kamath MD, MSPH, Associate Professor, Department of Pediatrics, University

of Cincinnati

63. Jan Hart MSPH, Clinical epidemiologist, Trauma Research LLC, Denver, CO

64. Grace Njau MPH, Epidemiologist, Maternal and Child Health Services, North Dakota

Department of Health, Bismarck, ND

65. Ashlee Cerda MPH, Healthcare Data Analyst, CO Community Managed Care Network

66. Stephanie Bengs, PA-C, MPH, PA-C, Swedish Hospital

67. Melissa Lindt BS, Graduate Student MPH, CSPH

68. Jennifer Cathcart MPH, Senior Clinical Coordinator, Division of Ophthalmic

Epidemiology, Department of Ophthalmology, CUSOM

D. Mentorship provided to Medical Students

69. Christina Ring MD, Kaiser Permanente, Department of Ob/Gyn, Westminster, CO

70. Ogechi Agwu MD, Internal Medicine, Cleveland, OH

71. Christine Warrick MD, Anesthesiology, Salt Lake City, UT

72. Abbie Foust MD, Highlands Integrative Pediatrics, Denver, CO

73. Haley Landwehr MD, Obstetrics and Gynecology, Winston Salem, NC

74. Alyssa Self BS, MD candidate, Medical student, CUSOM

75. Minh Trinh BS, Medical student, CUSOM

RESEARCH INTERESTS

– Retinopathy of Prematurity

– Age-related Macular Degeneration

– Outcomes from cataract surgery

– The complement system in human disease

– Links between events in the intra-uterine environment with Retinopathy of Prematurity

– The role of circulating proteins in eye diseases

RESEARCH ACTIVITIES, SUPPORT AND GRANTS

Active Research Projects, Support and Grants:

1. Postnatal growth and retinopathy of prematurity (G-ROP)

PI: Gil Binenbaum MD

Role: Co-Investigator

Agency: National Eye Institute (NEI)

Grant number: 5 R01 EY021137 03


Period: 09/30/12 - 08/31/17

Direct costs: $10,000 (approx.) per year to the Dept. Ophthalmology

Summary of specific aims of grant: To develop a prognostic model using postnatal

weight gain for severe ROP.

Grants Under Review:

1. Aptamer-based Models for Predicting Retinopathy of Prematurity

Role: Principal Investigator

Agency: National Eye Institute (NEI)

Grant number: R01EY028122

Period: 04/1/2018 - 03/31/2023

Direct costs: $2,689,408 Indirect costs: $567,056 Total Costs: $3,256,464

Summary of specific aims of grant: To address the role of ROP signaling pathways

through aptamer-based proteomics. Firstly, we will study the relationship of high signal

proteins in plasma samples taken early in the postnatal period with severe ROP.

Secondly, we will develop a statistical model to improve severe ROP risk assessment

based on panels of high signal proteins and established ROP risk factors. Thirdly, we will

study trends in concentrations of proteins in infants who develop severe, low-grade and

no ROP. Finally, we will determine if levels of high signal proteins and other proteins

measured by the technology around the time of the first ROP examination are related to

the development or severity of ROP.

Completed Research Projects, Support and Grants:

1. Complement Activation and Hypertensive Diseases of Pregnancy


Agency: Eunice Kennedy Shriver NICHD

Grant number: 1 R21 HD068961-01A1

Period: 12/01/2011 - 11/30/2013 (in extension period 2014)

Direct costs: $420,750

Percent effort: 20%

Summary of specific aims of grant: To determine the association between complement

activation fragments measured at multiple time points in gestation with subsequent

development of hypertensive diseases of pregnancy in a longitudinal study design.

2. Exploring the Fuel-Mediated Programming of Neonatal Growth

PI: Dana Dabelea MD, PhD


Agency: National Institute of Diabetes, Digestive & Kidney Diseases (NIDDK)

Grant number: 1R01DK076648

Period: 9/1/09 - 7/31/2014

Direct costs: $496,000 per year

Percent effort: 2.5%

Summary of specific aims of grant: This project will explore a timely public health

problem by testing the hypothesis that maternal obesity programs neonatal growth,

fatness and metabolism, and by identifying specific mediators of these effects that can be

targeted by future interventions. We will enroll 1,920 pregnant women before 15 weeks


of gestation and follow them prospectively through delivery in order to explore the

relationships between maternal body size and behaviors during pregnancy, intra-partum

fuels, markers of inflammation and insulin resistance, and infant body size and fatness.

3. To Support the Data Management Core of the Colorado “Baby Blanket” Perinatal

Research Program


Agency: CUSOM AEF of Strategic Infrastructure for Research Initiatives

Period: 1/1/2011 - 12/31/ 2013


4. Colorado Clinical Translational Institute PI: Ronald J. Sokol, MD

Role: Co-director, Child Maternal Health Section, CCTSI

Agency: National Center for Research Resources (NCRR)

Grant Numbers: NIH-NCATS, UL1TR001082, TL1TR001081, KL2TR001080

5. The Relationship of Allelic Variations in Genes Encoding the Complement

Alternative Pathway-Associated Proteins with Preterm Birth.


Agency: Newborn Hope Colorado

Period: 3/1/2012 - 2/28/2013


Summary of specific aims of grant: To determine if variations in genes encoding the

proteins of the complement system are related to preterm birth.

6. Colorado Maternal Fetal Medicine Unit PI: Ronald Gibbs MD

Role: Co-Investigator until 12/2013

Agency: Maternal Fetal Medicine Units Network, NICHD

Grant number: 1 U10 HD068282-01

Period: 04/01/11 - 03/31/16

Direct costs: $1,000,000

Percent effort: 20% (from Department of Ob/Gyn)

Summary of specific aims of grant: To become a site for the Maternal Fetal Medicine

Units (MFMU) Network protocols.

7. National Children’s Study

PI: Dana Dabelea MD, PhD



Grant number: HHSN27500800018C

Period: 9/26/10 - 9/25/11

Direct costs: $3,314,649

Percent effort: 2.5%


Summary of specific aims of grant: The National Institute of Child Health and

Development recently released a request for proposals inviting sites across the United

States to be part of the National Children’s Study (NCS). Here in Colorado, the Denver

Metro area and Douglas County have been chosen as potential sites for the study. The

aim of the study is to recruit 250 pregnant women per year for 4 years at each site. The

women will be recruited from the community and monitored closely throughout

pregnancy by a team of investigators. The children will be followed for 21 years. During

pregnancy and after birth information will be collected on many exposures and outcomes.

8. Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial

Role: Principal Investigator at the Denver site


Type: Subcontract with University of Utah

Period: 1/1/2009 - 12/31/2011


Percent effort: ~ 5 to 10% over duration of grant

Summary of specific aims of grant: To determine the effect of LDA in combination with

folic acid on the incidence of live births relative to placebo plus folic acid, 2) To

determine the effect of LDA in combination with folic acid on the incidence of hCG

detected pregnancy relative to placebo plus folic acid, 3) To determine the effect of LDA

in combination with folic acid treatment on the incidence of clinically recognized hCG

detected pregnancy (by 6.5 week ultrasound relative to placebo plus folic acid, 4) To

determine the effect of LDA in combination with folic acid on specific pregnancy

outcomes (e.g. gestational age preterm birth, birthweight [small for gestational age],

major neonatal complications, length of hospital stay for infant, preeclampsia, and cost)

relative to placebo plus folic acid.

9. Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through

Epigenetics

PI: Pia Hauk MD, National Jewish Health


Agency: National Heart, Lung, and Blood Institute (NHLBI)

Period: 8/1/10 - 9/1/2011

Type: Challenge grant


Percent effort: 4%

Summary of specific aims of grant: There is widespread use of antenatal dietary

supplementation with the goal of preventing in utero and neonatal abnormalities, but

there has been little investigation about the potential risks of such interventions in

expectant mothers. Folic acid, vitamin B12, and choline are methyl donors that, taken

during pregnancy, have the potential through hypermethylation to alter the expression of

genes that regulate development of allergy, increasing the risk in babies for developing an

allergic disease. Our research team proposes to determine if such concerns about methyl

donor supplementation are justified and pose a real threat in expectant mothers already at

risk for transmitting an atopic genetic predisposition to their infants.


10. 2009 H1N1 Influenza in Pregnancy: A Multicenter Cohort Study of Pregnancy

Outcomes among Laboratory-Confirmed Cases Role: Co-PI with Barbra Fisher MD, PhD

Agency: American College of Obstetrics and Gynecology

Period: 01/01/2012 - 12/31/201


11. PAPP-A2 as a diagnostic biomarker for preeclampsia PI: VD Winn MD, PhD


Agency: CCTSI

Grant Number: CCTSI

Period: 1/1/2010 - 12/31/2012


Summary of specific aims of grant: To determine if PAPP-A2 is a diagnostic biomarker

for Preeclampsia.

12. Vitamin D and adverse pregnancy outcomes PI: Meghan Donnelly MD


Agency: Newborn Hope

Grant Number: Newborn Hope

Period: 3/1/11 - 3/1/2012


Summary of specific aims of grant: To determine the contribution of Vitamin D in early

pregnancy to adverse pregnancy outcomes.

13. Complement Activation and Preterm Birth Role: Principal Investigator

Agency: Newborn Hope

Period: 1/20/2006 - 1/20/2007


Summary of specific aims of grant: To determine the contribution of complement

activation in early pregnancy to subsequent preterm birth.

14. H1N1 in pregnancy Role: Principal Investigator for mentee Barbra Fisher MD, PhD

Agency: Department of Ob/Gyn AEF funds, CUSOM

Period: 2011


Summary of specific aims of grant: To determine the contribution of H1N1 infection in

pregnancy to adverse pregnancy outcomes.

15. Complement Activation and Pregnancy Loss Role: Principal Investigator



Grant number: K23 HD049684

Type: K23

Period: 9/12/2006 - 8/31/2010


Percent effort: 75%

Summary of specific aims of grant: Pregnancy loss is the most common complication of

pregnancy. Recent studies in experimental murine models suggest a significant

contribution of complement activation to immunologically-related pregnancy loss. The

aim of this proposal is to translate these observations to a human study in the setting of a

Mentored Patient-Oriented Research Career Development Award. The primary aim of

this study is to determine whether elevated levels of split products generated by the

alternative or classical pathway of complement activation are associated with pregnancy

loss.

16. Antiangiogenic Factors, Complement Activation Fragment Bb and Preeclampsia


Agency: American Heart Association

Grant number: 0865481G

Type: Beginning grant-in aid

Period: 7/1/08 - 6/30/2010


Percent effort: 10%

Summary of specific aims of grant: The specific aims of this project are to determine

between 10 and 20 weeks gestation: 1) If levels of the complement activation fragments

C4a, C3a, SC5b-9 predict the development of preeclampsia later in pregnancy, 2) If

levels of proangiogenic PlGF and the antiangiogenic factors sFlt-1 and sEng predict the

development of preeclampsia later in pregnancy, 3) If there is an association between

complement activation fragments and angiogenic factors.

17. Antiangiogenic Factors, Complement Activation Fragment Bb and Preeclampsia


Agency: 2007 Junior Faculty Research Development Award, List Family

Foundation Center for Women’s Health Research

Period: 9/07 - 9/08


Summary of specific aims of grant: The specific aims of this project are to determine in

early pregnancy: 1) If there is an association between the complement activation

fragment Bb and antiangiogenic factors, 2) If antiangiogenic factors are risk factors for

preeclampsia 3) If elevated levels of antiangiogenic factors and the complement

activation product Bb together are better predictors of preeclampsia than individual

measures of these markers.

18. Complement activation and adverse pregnancy outcomes Role: Principal Investigator

Agency: Department of Ob/Gyn AEF funds, CUSOM

Period: 8/1/05 - 1/1/06


Direct costs: $22,025.91

Summary of specific aims of grant: as for K23

19. Outcomes in spontaneous and iatrogenic multiple birth Role: Principal Investigator

Agency: AHRQ

Grant Number: R03 HS10700-01

Period: 9/30/00 - 12/31/02


Summary of specific aims of grant: 1) describe conditions in the mother’s infertility

history that necessitated assisted reproductive treatment, 2) describe the method of

assisted reproduction that resulted in the pregnancy (e.g. ovulation induction, in vitro

fertilization (IVF)), 3) compare maternal risk factors for adverse pregnancy outcomes and

prenatal and intrapartum events between multiple gestations (twins and higher order

pregnancies) conceived through assisted reproductive interventions and those conceived

spontaneously 4) compare maternal outcomes of multiple gestations conceived through

assisted reproductive interventions with those conceived spontaneously.

20. Perinatal outcomes following assisted conception Role: Principal Investigator

Agency: American College of Obstetrics and Gynecology Roy M Pitkin

AwardType: Award for meritorious research

Period: 5/01/03 - 5/01/04


Summary of specific aims of grant: as for R03

21. Outcomes in spontaneous and iatrogenic multiple birth

PI: R McDuffie MD


Agency: Kaiser Permanente Colorado Clinical Research Unit

Type: AEF

Period: 11/01/02 - 12/31/03


22. Outcomes in spontaneous and iatrogenic multiple birth


Agency: Kaiser Permanente Colorado Clinical Research Unit

Type: AEF

Period: 1/01/99 - 4/30/00

Direct costs: ~$25,000


23. Prospective study of the value of antiphospholipid antibodies in predicting

pregnancy outcome


Agency: Arthritis Foundation, Rocky Mountain Chapter


Type: local grant

Period: 01/01/1993 - 12/31/1995

Direct costs: ~$10,000


BIBLIOGRAPHY

Peer-reviewed Publications

1. McEvoy M, Drury R, Keane (Lynch) A, McKeever M, Drury MI. Fasting

hyperglycaemia in insulin dependent diabetics. Irish journal of medical science. 1982;

151(11):325-33. PubMed, PMID: 6759458

2. Keane (Lynch) A, Woods R, Dowding V, Roden D, Barry C. Anticardiolipin antibodies

in rheumatoid arthritis. British journal of rheumatology. 1987; 26(5):346-50. PubMed

PMID: 3664159

3. Keane (Lynch) A, Foley-Nolan D, Barry C, Coughlan RJ. Reiter's syndrome precipitated

by a typhoid vaccination. British journal of rheumatology. 1988; 27(6):496-7. PubMed

PMID: 3203199

4. Keane (Lynch) A, Woods R, Foley-Nolan D, Roden D, Coughlan R, Barry C. A serial

study of anticardiolipin antibody and antimitochondrial antibody type M5 in a patient

with polyarthritis and polymyositis. British journal of rheumatology. 1989; 28(2):158-60.

PubMed PMID: 2706420

5. Lynch A, Marlar R, Murphy J, Davila G, Santos M, Rutledge J, Emlen W.

Antiphospholipid antibodies in predicting adverse pregnancy outcome. A prospective

study. Annals of internal medicine. 1994; 120(6):470-5. PubMed PMID: 8093135

6. Lynch AM, Rutledge JH, Stephens JK, Murphy JR, Marlar RA, Davila GH, Santos ME,

Emlen W. Longitudinal measurement of anticardiolipin antibodies during normal

pregnancy: a prospective study. Lupus. 1995; 4(5):365-9. PubMed PMID: 8563730

7. Lynch A, Silver R, Emlen W. Antiphospholipid antibodies in healthy pregnant women.

Rheumatic diseases clinics of North America. 1997; 23(1):55-70. PubMed PMID:

9031374

8. Lynch A, Byers T, Emlen W, Rynes D, Shetterly SM, Hamman RF. Association of

antibodies to beta2-glycoprotein 1 with pregnancy loss and pregnancy-induced

hypertension: a prospective study in low-risk pregnancy. Obstetrics and gynecology.

1999; 93(2):193-8. PubMed PMID: 9932554

9. Lynch A, McDuffie R, Murphy J, Faber K, Leff M, Orleans M. Obstet Gynecol. 2001

Feb;97(2):195-200 Assisted Reproductive Technologies and Multiple Birth. Obstet

Gynecol. 2002 Mar;99(3):445-51. PMID: 11864672

10. Lynch A, McDuffie R Jr, Murphy J, Faber K, Orleans M. Preeclampsia in multiple

gestation: the role of assisted reproductive technologies. Obstetrics and gynecology.

2002; 99(3):445-51. PubMed PMID: 11864672

11. Lynch A, McDuffie R, Stephens J, Murphy J, Faber K, Orleans M. The contribution of

assisted conception, chorionicity and other risk factors to very low birthweight in a twin


cohort. BJOG: an international journal of obstetrics and gynaecology. 2003; 110(4):405-

10. PubMed PMID: 12699803

12. Best AC, Lynch AM, Bozic CM, Miller D, Grunwald GK, Lynch DA. Quantitative CT

indexes in idiopathic pulmonary fibrosis: relationship with physiologic impairment.

Radiology. 2003; 228(2):407-14. PubMed PMID: 12802000

13. Schlaff WD, Lynch AM, Hughes HD, Cedars MI, Smith DL. Manipulation of the pill-

free interval in oral contraceptive pill users: the effect on follicular suppression.

American journal of obstetrics and gynecology. 2004; 190(4):943-51. PubMed PMID:

15118618

14. Behbakht K, Lynch A, Teal S, Degeest K, Massad S. Social and cultural barriers to

Papanicolaou test screening in an urban population. Obstetrics and gynecology. 2004;

104(6):1355-61. PubMed PMID: 15572502

15. Dugoff L, Lynch AM, Cioffi-Ragan D, Hobbins JC, Schultz LK, et al. First trimester

uterine artery Doppler abnormalities predict subsequent intrauterine growth restriction.

American journal of obstetrics and gynecology. 2005; 193(3 Pt 2):1208-12. PubMed

PMID: 16157139

16. Kahn BF, Davies JK, Lynch AM, Reynolds RM, Barbour LA. Predictors of glyburide

failure in the treatment of gestational diabetes. Obstetrics and gynecology. 2006;

107(6):1303-9. PubMed PMID: 16738156

17. Lynch A, McDuffie R Jr, Lyons E, Chase M, Orleans M. Perinatal loss among twins.

The Permanente Journal. 2007; 11(1):7-12. PubMed PMID: 21472048, PMCID:

PMC3061385

18. Best AC, Meng J, Lynch AM, Bozic CM, Miller D, Grunwald GK, Lynch DA.

Idiopathic pulmonary fibrosis: physiologic tests, quantitative CT indexes, and CT visual

scores as predictors of mortality. Radiology. 2008; 246(3):935-40. PubMed PMID:

18235106

19. Lynch AM, Murphy JR, Byers T, Gibbs RS, Neville MC, Giclas PC, Salmon JE, Holers

VM. Alternative complement pathway activation fragment Bb in early pregnancy as a

predictor of preeclampsia. American journal of obstetrics and gynecology. 2008; 198(4):

385.e1-9. NIHMSID: NIHMS40061 PubMed PMID: 18221926, PMCID: PMC2362503

20. Lynch AM, Gibbs RS, Murphy JR, Byers T, Neville MC, Giclas PC, Salmon JE, Van

Hecke TM, Holers VM. Complement activation fragment Bb in early pregnancy and

spontaneous preterm birth. American journal of obstetrics and gynecology. 2008; 199(4):

354.e1-8. NIHMSID: NIHMS72302 PubMed PMID: 18928972, PMCID: PMC2586079

21. Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch AM. Neonatal outcomes after

elective cesarean delivery. Obstetrics and gynecology. 2009; 113(6):1231-8. NIHMSID:

NIHMS447984 PubMed PMID: 19461417, PMCID: PMC3620716


22. Lynch AM, Murphy JR, Gibbs RS, Levine RJ, Giclas PC, Salmon JE, Holers VM. The

interrelationship of complement-activation fragments and angiogenesis-related factors in

early pregnancy and their association with pre-eclampsia. BJOG : an international journal

of obstetrics and gynaecology. 2010; 117(4):456-62. PubMed PMID: 20074261

23. Lynch AM, Salmon JE. Dysregulated complement activation as a common pathway of

injury in preeclampsia and other pregnancy complications. Placenta. 2010; 31(7):561-7.

NIHMSID: NIHMS195267 PubMed PMID: 20427084, PMCID: PMC2900404

24. Lynch AM, Gibbs RS, Murphy JR, Giclas PC, Salmon JE, Holers VM. Early elevations

of the complement activation fragment C3a and adverse pregnancy outcomes. Obstetrics

and gynecology. 2011; 117(1):75-83. PubMed PMID: 21173647

25. Fisher BM, Scott J, Hart J, Winn VD, Gibbs RS, Lynch AM. Behaviors and perceptions

regarding seasonal and H1N1 influenza vaccination during pregnancy. American journal

of obstetrics and gynecology. 2011; 204(6 Suppl 1):S107-11. PubMed PMID: 21419386

26. Kunze M, Hart JE, Lynch AM, Gibbs RS. Intrapartum management of premature rupture

of membranes: effect on cesarean delivery rate. Obstetrics and gynecology. 2011;

118(6):1247-54. PubMed PMID: 22105253

27. Fisher BM, Van Bockern J, Hart J, Lynch AM, Winn VD, Gibbs RS, Weinberg A.

Pandemic influenza A H1N1 2009 infection versus vaccination: a cohort study

comparing immune responses in pregnancy. PloS one. 2012; 7(3): e33048. PubMed

PMID: 22457731, PMCID: PMC3310855

28. Lynch AM, Eckel RH, Murphy JR, Gibbs RS, West NA, Giclas PC, Salmon JE, Holers

VM. Prepregnancy obesity and complement system activation in early pregnancy and the

subsequent development of preeclampsia. American journal of obstetrics and

gynecology. 2012;206(5):428.e1-8. PubMed PMID: 22542119

29. Metz TD, Lynch AM, Wolfe P, Barry JS, Galan HL. Effect of small for gestational age

on hemodynamic parameters in the neonatal period. J Matern Fetal Neonatal Med. 2012

Oct;25(10):2093-7. PubMed PMID: 22475050

30. Behrendt N, Gibbs RS, Lynch A, Hart J, West NA, Iams JD. Rate of change in cervical

length in women with vaginal bleeding during pregnancy. Obstetrics and gynecology.

2013; 121(2 Pt 1):260-4. PubMed PMID: 23344274

31. Schisterman EF, Silver RM, Perkins NJ, Mumford SL, Whitcomb BW, Stanford JB,

Lesher LL, Faraggi D, Wactawski-Wende J, Browne RW, Townsend JM, White M,

Lynch AM, Galai N. A randomized trial to evaluate the effects of low-dose aspirin in

gestation and reproduction: design and baseline characteristics. Paediatric and perinatal

epidemiology. 2013; 27(6):598-609. NIHMSID: NIHMS523913 PubMed PMID:

24118062, PMCID: PMC3821875

32. Naresh A, Fisher BM, Hoppe KK, Catov J, Xu J, Hart, J, Lynch AM, Gibbs RS,

Eschenbach D, Gravett M, Beigi R. A multicenter cohort study of pregnancy outcomes


among women with laboratory-confirmed H1N1 influenza. Journal of perinatology:

official journal of the California Perinatal Association. 2013; 33(12):939-43. PubMed:

24051575

33. Hoffman MC, Rumer KK, Kramer A, Lynch AM, Winn VD. Maternal and fetal

alternative complement pathway activation in early severe preeclampsia. American

journal of reproductive immunology (New York, N.Y.: 1989). 2014; 71(1):55-60.

NIHMSID: NIHMS595633 PubMed PMID: 24128411, PMCID: PMC4067768

34. Lynch AM, Hart JE, Agwu OC, Fisher BM, West NA, Gibbs RS. Association of

extremes of prepregnancy BMI with the clinical presentations of preterm birth. American

journal of obstetrics and gynecology. 2014; 210(5): 428.e1-9. PubMed PMID: 24321446

35. Schisterman EF, Silver RA, Lesher LL, Faraggi D, Wactawski-Wende JM, Townsend

JM, Lynch AM, Perkins NJ, Mumford SL, Galai N. Preconception low-dose aspirin and

pregnancy outcomes: results from the EAGeR randomised trial. Lancet. 2014;

384(9937):29-36. NIHMSID: NIHMS612159 PubMed PMID: 24702835, PMCID:

PMC4181666

36. Starling AP, Brinton JT, Glueck DH, Shapiro AL, Harrod CS, Lynch AM, Siega-Riz

AM, Dabelea D. Associations of maternal BMI and gestational weight gain with neonatal

adiposity in the Healthy Start study. The American Journal of Clinical Nutrition. 2015;

101(2):302-9. PubMed PMID: 25646327, PMCID: PMC4307203

37. Lesher LL, Matyas RA, Sjaarda LA, Newman SL, Silver RM, Galai N, Hovey KM,

Wactawski-Wende J, Emerick L, Lynch AM, Mead B, Townsend JM, Perkins NJ,

Mumford SL, Stanford J, Schisterman EF. Recruitment for longitudinal, randomised

pregnancy trials initiated preconception: lessons from the effects of aspirin in gestation

and reproduction trial. Paediatric and perinatal epidemiology. 2015; 29(2):162-7.

PubMed PMID: 25682951

38. Hoffman MC, Mahony R, Foley, Gibbs RS, Galen HL, Lynch AM. Comparison of the

incidence and clinical presentation of preterm birth less than 34 weeks’ gestation in

University Hospitals in Dublin, Ireland and Denver, Colorado. Clin Obstet Gynecol

Reprod Med 2015; 1(3): 68-71. DOI: 10.15761/COGRM.1000119

39. Wong LF, Schliep KC, Silver RM, Mumford SL, Perkins NJ, Ye A, Galai N, Wactawski-

Wende J, Lynch AM, Townsend JM, Faraggi D, Schisterman EF. The effect of a very

short interpregnancy interval and pregnancy outcomes following a previous pregnancy

loss. American journal of obstetrics and gynecology. 2015;212(3): 375.e1-11. NIHMSID:

NIHMS629856 PubMed PMID: 25246378, PMCID: PMC4346440

40. Silver RM, Ahrens K, Ph.D., Wong L, Perkins NJ, Galai N, Lesher LL, Faraggi D,

Wactawski-Wende J, Townsend JM, Lynch AM, Mumford SL, Sjaarda L, Schistermann

EF. Low-dose aspirin and preterm birth: a randomized controlled trial. Obstetrics and

gynecology. 2015; 125(4):876-84. PubMed PMID: 25751215


41. Schisterman E, Mumford S, Schliep K, Sjaarda L, Stanford J, Lesher L, Wactawski-

Wende J, Lynch A, Townsend J, Perkins N, Zarek S, Tsai M, Chen Z, Faraggi D, Galai

N, Silver R. Preconception low dose aspirin and time to pregnancy: findings from the

effects of aspirin in gestation and reproduction randomized trial. The Journal of clinical

endocrinology and metabolism. 2015; 100(5):1785-91. PubMed PMID: 25710565,

PMCID: PMC4422888.

42. Moore GS, Post AL, West NA, Hart JE, Lynch AM. Fetal weight estimation in diabetic

pregnancies using the gestation-adjusted projection method: comparison of two timing

strategies for third-trimester sonography. Journal of ultrasound in medicine: official

journal of the American Institute of Ultrasound in Medicine. 2015; 34(6):971-5. PubMed

PMID: 26014315

43. Warrick CM, Hart, JE, Lynch AM, Hawkins JA, Bucklin BA. Prevalence and

descriptive analysis of congenital heart disease in parturients: Obstetric, Neonatal, and

Anesthetic Outcomes. J Clin Anesth. 2015 Jul 2. PMID: 26144911. Mentioned in:

London S. Obstetric Outcomes Fairly Good Despite Maternal CHD. Family Practice

News. 6/6/12.

44. Radin RG, Mumford SL, Silver RM, Lesher LL, Galai N, Faraggi D, Wactawski-Wende J,

Townsend JM, Lynch AM, Simhan HN, Sjaarda LA, Perkins NJ, Zarek SM, Schliep KC

Schisterman EF. Sex ratio following preconception low-dose aspirin in women with prior

pregnancy loss. 2015 Sep;125(9):3619-26. doi: 10.1172/JCI82357. Epub 2015 Aug 17.

PMCID: PMC4588294. Editor’s choice: Shaw TJ. Early evidence of male sensitivity.

Science Translational Medicine. 02 Sep 2015: Vol. 7, Issue 303, pp. 303ec151. DOI:

10.1126/scitranslmed.aad1830

45. Lynch AM, Wagner BD, Deterding RR, Giclas PC, Gibbs RS, Janoff EN, Holers VM,

Santoro NF. The Relationship of Circulating Proteins in Early Pregnancy with Preterm

Birth. Am J Obstet Gynecol. 2015 Nov 11. pii: S0002-9378(15)02294-2.

doi:10.1016/j.ajog.2015.11.001. [Epub ahead of print] PubMed PMID: 26576488.

46. Lynch AM, Wagner BD, Giclas PC, West NA, Gibbs RS, Holers VM. The Relationship of

Longitudinal Levels of Complement Bb during Pregnancy with Preeclampsia. Am J Reprod

Immunol. 2015 Oct 29. [Epub ahead of print] PubMed. PMID: 26510395.

47. Mumford SL, Silver RM, Sjaarda LA, Wactawski-Wende, J, Townsend JM, Lynch AM,

Galai N P, Lesher LL, Faraggi D, Perkins NJ, Schliep KC, Zarek SM,, Schisterman EF.

Expanded Findings from A Randomized Controlled Trial of Preconception Low Dose

Aspirin and Pregnancy Loss. Hum Reprod. 2016 Mar;31(3):657-65. doi:

10.1093/humrep/dev329. Epub 2016 Jan 11. PMCID: PMC4755442

48. Cao JH, Wagner BD, McCourt EA, Cerda A, Sillau S, Palestine A, Enzenauer RW. Mets-

Halgrimson RB, Paciuc-Beja M, Gralla J, Braverman RS, Lynch A. The Colorado-

Retinopathy of Prematurity Model (CO-ROP): Postnatal Weight Gain Screening

Algorithm. J AAPOS. 2016 Feb;20(1):19-24. doi: 10.1016/j.jaapos. 2015.10.017. PMID:

26917066.


49. Ahrens KA, Silver RM, Mumford SL, Sjaarda LA, Perkins NJ, Wactawski-Wende

J, Galai N, Townsend JM, Lynch AM, Lesher LL, Faraggi D, Zarek S, Schisterman EF.

Complications and Safety of Preconception Low-Dose Aspirin Among Women with

Prior Pregnancy Losses. Obstet Gynecol. 2016 Apr;127(4):689-98. doi:

10.1097/AOG.0000000000001301. PMCID: PMC4805457

50. Cao JH, Wagner BD, Cerda A, McCourt EA, Palestine A, Enzenauer RW, Braverman

RS, Wong RK, Tsui I, Gore C, Robbins SL, Puente MA Jr, Kauffman L, Kong L,

Morrison DG, Lynch, AM. Colorado Retinopathy of Prematurity Model: A Multi-

Institutional Validation Study. J AAPOS. 2016 May 7. pii: S1091-8531(16)30063-5. doi:

10.1016/j.jaapos.2016.01.017. [Epub ahead of print]. PMID: 27166790. Received an

award as a best AAPOS paper.

51. Lynch AM, Wagner BD, Mandava N, Palestine AG, Mourani PM, McCourt EA, Oliver

SCN, Abman SH. The relationship of novel plasma proteins in the early neonatal period

with retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):5076-

5082. doi: 10.1167/iovs.16-19653. PMCID: PMC505311

52. Bonnell LN, SooHoo JR, Seibold LK, Lynch AM, Wagner BD, Davidson RS, Taravella

MJ. One-day postoperative intraocular pressure spikes after phacoemulsification cataract

surgery in patients taking Tamsulosin. J Cataract Refract Surg. 2016 Dec;42(12):1753-8.

PubMed PMID: 28007106. Epub 2016/12/23. eng. Also published as a commentary in

the April 2017 issue of EyeWorld and in Practice Update January 24, 2017

53. Pugh SJ, Schisterman EF, Browne RW, Lynch AM, Mumford SL, Perkins NJ, Silver R,

Sjaarda L, Stanford JB, Wactawski-Wende J, Wilcox B, Grantz KL. Preconception

maternal lipoprotein levels in relation to fecundability. Hum Reprod. 2017 Mar 15:1-9.

doi: 10.1093/humrep/dex052. [Epub ahead of print]. PMID: 28333301.

54. Jung JL, Wagner BD, McCourt EA, Palestine AG, Cerda A, Cao JH, Enzenauer RW,

Singh JK, Braverman RS, Wymore E, Lynch AM. Validation of WINROP for detecting

retinopathy of prematurity in a North American cohort of preterm infants. J AAPOS.

2017 Jun;21(3):229-233. doi: 10.1016/j.jaapos.2017.05.004. Epub 2017 May 12. PMID:

28506724

55. Lynch AM, Wagner BD, Hodges JK, Thevarajah TS, McCourt EA, Cerda AM, Palestine

A, Gibbs R. The relationship of the subtypes of preterm birth with retinopathy of

prematurity. Am J Obstet Gynecol. 2017;217(3):354.e1-.e8. doi:

10.1016/j.ajog.2017.05.029. Epub 2017 May 22. PMID: 28545834. Award received.

56. McCourt EA, Wagner B, Jung J, Wymore E, Singh J, Enzenauer R, Braverman R, Lynch

A. Validation of the CHOP model for detecting severe retinopathy of prematurity in a

cohort of Colorado infants. Acta Ophthalmol. 2017 Jun 27. doi: 10.1111/aos.13506.

[Epub ahead of print] PMID: 28653816

57. Lazcano-Gomez G, Soohoo JR, Lynch A, Bonell LN, Martinez K, Turati M, Gonzalez-

Salinas Jimenez-Roman J, Kahook MY. Neovascular Glaucoma: A Retrospective

Review from a Tertiary Eye Care Center in Mexico. J Curr Glaucoma Pract

http://www.ncbi.nlm.nih.gov/pubmed/?term=Ahrens%20KA%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Silver%20RM%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Mumford%20SL%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Sjaarda%20LA%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Perkins%20NJ%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Wactawski-Wende%20J%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Wactawski-Wende%20J%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Galai%20N%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Townsend%20JM%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Lynch%20AM%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Lesher%20LL%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Faraggi%20D%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Zarek%20S%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/?term=Schisterman%20EF%5BAuthor%5D&cauthor=true&cauthor_uid=26959198

http://www.ncbi.nlm.nih.gov/pubmed/26959198

http://www.ncbi.nlm.nih.gov/pubmed/27166790

https://www.ncbi.nlm.nih.gov/pubmed/28333301

https://www.ncbi.nlm.nih.gov/pubmed/28333301


2017;11(2):48-51. PMID: 28924338 PMCID: PMC5577119 DOI: 10.5005/jp-journals-

10028-1222

58. Radin R, Mumford S, Sjaarda L, Wactawski-Wende J, Lynch, A, Perkins N, Lesher L,

Wilcox B, Schisterman E. Preconception attempted and actual weight change in relation

to pregnancy loss: A prospective cohort study. British Journal of Obstetrics and

Gynaecology, accepted.

Scientific Abstracts

1. Lynch A, Woods R, Barry C, Roden D. Anticardiolipin antibodies in Rheumatoid

Arthritis. Podium presentation. Society of Irish and American Rheumatologists. Dublin,

Ireland 1985.

2. Lynch A, Marlar R, Murphy J, Davila G, Emlen W. Prospective study of the value of

antiphospholipid antibodies in predicting pregnancy outcome. Podium presentation.

American College of Rheumatology annual meeting 1991, Boston, MA. Arthritis and

Rheumatism 34 (9) S95, 1991.

3. Lynch A, Marlar R, Murphy J, Davila G, Santos M, Stantejsky S, Emlen W. The

predictive value of antiphospholipid antibodies in determining adverse fetal outcome.

Podium presentation. American College of Rheumatology annual meeting 1992. Atlanta,

GA. Arthritis and Rheumatism 35 (9) S61, 1992.

4. Hassell K, Lynch A, Marlar R, Murphy J, Davila G, Santos M, Stantejsky S, Emlen W.

Prospective study of the role of antiphospholipid antibodies in predicting pregnancy

outcome. Poster presentation. 14th Congress of the International Congress of Thrombosis

and Hemostasis. New York. 1993 Journal of Thrombosis and Hemostasis 69 (6): 1229,

1993.

5. Lynch A, Marlar R, Murphy J, Davila G, Santos M, Stantejsky S, Emlen W. The

predictive value of antiphospholipid antibodies in determining adverse fetal outcome.

Poster presentation. American College of Rheumatology annual meeting, 1993, San

Antonio, Texas. Arthritis and Rheumatism 36 (9): S75, 1993.

6. Lynch A, Rutledge J, Murphy J, Marlar R, Davila G, Santos M, Emlen W. Longitudinal

measurement of antiphospholipid antibodies during pregnancy. Poster discussion,

American College of Rheumatology annual meeting 1993. San Antonio, Texas.

7. Lynch A, Rutledge J, Stephens J, Murphy J, Marlar R, Davila G, Santos M, Emlen W.

Longitudinal measurement of anticardiolipin antibodies in normal pregnancy: a

prospective study. Poster presentation. Sixth international symposium on

antiphospholipid antibodies. Leuven, Belgium, 1994

8. Lynch A, Rutledge J, Stephens J, Murphy J, Marlar R, Davila G, Santos M, Emlen W.

Longitudinal measurement of anticardiolipin antibodies in normal pregnancy: a

prospective study. Podium presentation Thirteenth annual epidemiologic research

exchange. University of Colorado School of Medicine, 1994.


9. Lynch A, Emlen W, Gordon S Prevalence of antiphospholipid antibodies in a cancer

population-A pilot study. Poster at American College of Rheumatology annual meeting

Orlando, Florida 1996 Lupus 5 (5) Abstract 82 523.

10. Lynch A, McDuffie R, Murphy J, Faber K, Orleans M. Preeclampsia in multiple

gestation: the role of assisted reproductive technologies. Poster presentation. Society of

Maternal Fetal Medicine meeting. New Orleans, January 2002. Am J Obstet Gynecol

185(6): S155, 2001

11. Lynch A, McDuffie R, Murphy J, Faber K, Orleans M. Pregnancy-Induced Hypertension

in Twin Pregnancy: Poster presentation. The Role of Donor Oocytes. . Society of

Maternal Fetal Medicine meeting. New Orleans, February 2004.

12. Lynch DA, Best AC, Lynch AM, Miller D, Khambatta F, Bozic C. Progression of

quantitative CT indices in patients with IPF. Poster presentation. RSNA, Chicago,

Illinois, 2001. Radiology 2001 221: 356P

13. Lynch A, Murphy J, Byers T, Gibbs R, Neville M, Giclas P, Holers VM. Elevated

Levels of Complement Split Product Bb are Associated with Subsequent Development of

Gestational Hypertension-Preeclampsia. Podium presentation. Society for Pediatric and

Perinatal Epidemiology Research, 20th Annual Meeting, Boston Mass. June 18-19, 2007.

14. Lynch A, Murphy J, Byers T, Gibbs R, Neville M, Giclas P, Holers VM. l. Alternative

Complement Pathway Activation Fragment Bb in Early Pregnancy as Predictor of

Preeclampsia. Podium presentation. The Joint meeting of the Society for Social

Medicine and International Epidemiological Association, Cork, Ireland September 12-14,

2007. Journal of Epidemiology and Community Health. 2007;61 Suppl 1: A2.

15. Lynch A, Murphy J, Byers T, Gibbs R, Neville M, Giclas P, Holers VM. Elevated levels

of the complement split product Bb in early pregnancy are associated with subsequent

development of preeclampsia. Poster presentation. XIth European Meeting on

Complement in Human Disease, Cardiff, Wales 8 -11th September 2007. Molecular

Immunology 2007;44 3953.

16. Lynch A, Gibbs R, Murphy J, Neville M, Byers T, Giclas P, Holers VM. Complement

Activation and Spontaneous Preterm Birth. Poster presentation. SGI annual meeting

2008Reproductive Sciences 2008;15 No. 1 (supplement) 183A

17. Lynch A, Murphy J, R L, Gibbs R, Giclas P, Byers T, et al. Complement activation

fragment Bb, angiogenic factors and preeclampsia. Podium and poster # O64

presentation. XXII International Complement Workshop, Basel, Switzerland 28

September- 2 October 2008.Molecular Immunology 2008; 45:4117.

18. Hoffman C, Mahony R, Gibbs R, Foley M. Galan H, O’Herlihy C, Lynch A. A

Comparison of the Incidence of Preterm Birth < 34 Weeks Gestation among Women in

Dublin, Ireland and Denver, Colorado. Poser presentation. Society for Maternal-Fetal

Medicine, 29th Annual Meeting, San Diego, California January 26-31, 2009.


19. Lynch A, Gibbs R, Murphy J, Giclas P, Salmon J, Byers T, Holers VM. Early

complement activation and subsequent risk for gestational hypertension. Poster # 246

presentation. Society for Maternal-Fetal Medicine, 29th Annual Meeting, San Diego,

California January 26-31 2009. American Journal Obstetrics and Gynecology 2008

199(6A): S80.

20. Kamath BD, Todd JK, Glazner JE, Lezotte D, Lynch A. Neonatal outcomes after elective

Cesarean section, Pediatric Academic Societies, Baltimore, Maryland, May 2009.

American Journal Obstetrics and Gynecology 2009;113(6):1231-8.

21. Hoffman MC, Winn V, Lynch A. Alternative complement pathway activation fragment

Bb is elevated in maternal and umbilical cord plasma of women and fetuses with

preeclampsia. Poster presentation. 30th Annual Scientific Meeting of the Society for

Maternal-Fetal Medicine, Chicago, IL, February 1-6, 2010. Am J Obstet Gynecol 2009;

201 (6 Suppl 1): S279.

22. Dugoff L, Hancock N, Melendez B, Schneider J, Galan H, Wheeler M, Davies J, Lynch

A, Hobbins JC. Second trimester uterine artery Doppler in women with abnormal quad

screen analytes. Podium presentation at the 30th Annual Scientific Meeting of the Society

for Maternal-Fetal Medicine, Chicago, IL, February 1-6, 2010. Am J Obstet Gynecol

2009; 201 (6 Suppl 1): S259.

23. Metz TD, Lynch AM, Wolfe PJ, Barry JS, Galan HL. The effect of small for gestational

age on hemodynamic parameters in the neonatal period: a case-control study. Poster

presentation at the 57th Annual Meeting of the Society for Gynecologic Investigation,

Orlando, FL, March 254-27, 2010. Reprod Sci 2010; 17 (3 Suppl); 107A

24. Lynch A, Murphy J, Gibbs R, Giclas P, Salmon J, Holers VM. C3a and adverse

pregnancy outcomes. Poster presentation. XXIII International Complement Workshop,

New York, New York, August 1-5, 2010.

25. Lynch A, Eckel R, Murphy J, Giclas P, Holers VM. The complement system in obesity.

Poster presentation. XXIII International Complement Workshop, New York, New York,

August 1-5, 2010.

26. Thompson LC, Hart JE, Lynch A, Gibbs RS. Select Risk Factors for Abdominal Wound

Infections (AWI) Among Cesarean Deliveries from 2000 through 2006. Poster

presentation. Infectious Diseases Society for Obstetrics and Gynecology (IDSOG). Santa

Fe, NM, August 5-7, 2010.

27. Fisher B, Scott J, Hart J, Winn VD, Gibbs RS, MD, Lynch AM. Behaviors, Attitudes,

and Perceptions Regarding Seasonal and H1N1 Influenza Vaccination During the 2009-

2010 Season. Poster presentation. Infectious Diseases Society for Obstetrics and

Gynecology (IDSOG). Santa Fe, NM, August 5-7, 2010.

28. Fisher B, Scott J, Hart J, Winn VD, Gibbs RS, Lynch A. Course of Influenza-Like Illness

at the University of Colorado Hospital (UCH). Poster presentation. Infectious Diseases

Society for Obstetrics and Gynecology (IDSOG). Santa Fe, NM, August 5-7, 2010.


29. Kunze M, Hart JE, Lynch A, Gibbs RS. Route of Delivery and Chorioamnionitis among

1026 Women with Premature Rupture of Membranes. Poster presentation. Infectious

Diseases Society for Obstetrics and Gynecology (IDSOG). Santa Fe, NM, August 5-7,

2010.

30. Kunze M, Hart JE, Lynch A, Gibbs RS. Newborn Outcomes among 1026 Women with

Premature Rupture of Membranes. Poster presentation. Infectious Diseases Society for

Obstetrics and Gynecology (IDSOG). Santa Fe, NM, August 5-7, 2010.

31. Fisher B, Scott J, Hart J, Lynch A, Winn VD, Weinberg A, Gibbs RS. Pandemic

Influenza A H1N1 2009 Infection versus Vaccination: A Cohort Study Comparing

Immune Responses in Pregnancy. Poster presentation. Society for Maternal-Fetal

Medicine, 31st Annual Meeting, San Francisco, CA, February 2011.

32. Tyler K, Fisher B, Winn V, Lynch A, Scott J, Post M. Fetal Vascular Lesions are

increased in Placentas from Women Infected with Pandemic H1N1 Influenza. TX Poster

presentation. United States and Canadian Academy of Pathology Meeting, February 26-

March 4, 2010 San Antonio, TX.

33. Fisher B, Scott J, Hart J, Gibbs R, Lynch A, Post M, Winn V. H1N1 Influenza and

Pregnancy: Does Antenatal Illness Cause Placental Pathology? Poster presentation. SGI

58th Annual Meeting, Miami, Florida, 2011

34. Naresh A, Fisher BM, Hoppe KK, Catov J, Hart J, Lynch A, Gibbs RS, Eschenbach D,

Gravett M, Beigi R. H1N1 influenza in pregnancy: A multicenter follow-up study of

pregnancy outcomes among pcr proven cases. Poster presentation. IDSOG, Chicago Il.

August 2011.

35. Lynch A, Eckel RH, Murphy J, Gibbs RS, Giclas P, West N, Salmon J, Holers VM.

Prepregnancy obesity and complement system activation in early pregnancy and the

subsequent development of preeclampsia. Poster presentation #167. XXIII European

Meeting of Complement in Human Disease. Leiden, The Netherlands, August 21-24,

2011. Molecular Immunology 2011; 48:1718.

36. Behrendt, Nicholas, Hart J, Lynch AM, West NW, Gibbs RS. Cervical shortening and

vaginal bleeding in pregnancies complicated by preterm birth. Poster presentation.

SMFM's 32nd Annual Meeting February 10, 2012 Dallas, TX.

37. Fisher B, Scott J, Hart J, Lynch AM, Winn V, Gibbs RS, Weinberg A. Antibody

responses to pandemic and seasonal influenza A H1N1 strains during the 2009-2010

influenza season: are the responses during pregnancy similar? Poster presentation.

SMFM's 32nd Annual Meeting February 10, 2012 Dallas, TX.

38. Kramer A, Hoffman C, Lynch A Winn VD, Maternal Serum PAPP-A2 Levels are

Elevated in Early Onset Preeclampsia at Time of Diagnosis and in Early Gestation".

Podium presentation, SGI, San Diego CA, 2012


39. Lavezzi J, Hart J, West NW, Rozance PJ, Lynch AM. Obesity during Pregnancy,

Independent of Gestational Diabetes, Increases Risk of Preeclampsia and Cesarean

Section. Poster presentation. Pediatric Academic Societies (PAS) Academic Societies

2012 Meeting April 28 –May 1 2012, Boston, Massachusetts.

40. Crume T, Briton JT, Harrod SC, Glueck D, Martinex M, Friedman J, Lynch AM,

Dabelea D. Maternal Lipids and Insulin Resistance Influence Neonatal Body Fat: The

Healthy Start Study. Poster Presentation at the American Diabetes Association’s 72nd

Scientific Sessions, June 8-12, 2012 in Philadelphia, PA.

41. Warrick C, Hart J, Lynch AM, Hawkins J, Bucklin B. Incidence and Descriptive

Analysis of Congenital Heart Disease in Parturients-Obstetrical and Anesthetic

Outcomes. Poster presentation. Society for Obstetric Anesthesia and Perinatology

(SOAP). 44th Annual Meeting, May 2-5, 2012, Monterey, California.

42. Lovgren T, Coulson C, Ross L, Hart J, Lynch A, Fuller A. Incidence of Coagulopathy in

Postpartum Hemorrhage. Poster presentation. Society for Obstetric Anesthesia and

Perinatology (SOAP). 42nd Annual Meeting, San Francisco, California.

43. Lynch A. IRB Review of Research Involving Pregnant Women: Biomedical Case

Studies, Podium presentation. Association for the Accreditation of Human Research

Protection Program, Inc. (AAHRP), May 2012, Denver, CO.

44. Lynch A, Emerick Anderson L, Santoro N, Lakin A, Hay W. Activities and Role of the

Perinatal Research Facilitation Core at the University of Colorado Denver Anschutz

Medical Campus, Aurora, CO. Podium presentation. 5th Annual Clinical Research

Management Workshop, June 4-5, 2012, Yale University, New Haven CT.

45. Hart J, Lynch AM, Gibbs RS. Clinical Chorioamnionitis (CC) after PPROM:

Relationship to Tocolytic and Steroid Use. Poster presentation. The 39th Annual

Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology, Aug

9-11, 2012, Whistler, BC, Canada

46. Lovgren T, Coulson C, Ross L, Hart J, Lynch A, Fuller A. Postpartum hemorrhage

associated coagulopathy: Relationship with severity of blood loss and postpartum

complications Poster presentation. Society for Obstetric Anesthesia and Perinatology

(SOAP). 44th Annual Meeting, May 2-5, 2012, Monterey, California.

47. Reed C, Lynch AM, Santoro N, Hay W, Lakin A, Fashaw L. Protecting a vulnerable

population: role of the perinatal research facilitation core. Poster presentation. The 4th

Annual Conference for the International Association of Clinical Research Nurses,

October 17-20, 2012, Houston, TX.

48. Agwu OC, Hart JE, Fisher BM, West NA, Gibbs RS, Lynch AM. Severe and moderate

thinness (prepregnancy body mass index < 17) as risk factors for spontaneous preterm

birth. Poster presentation. SMFM's 33rd Annual Meeting, February 2013, San Francisco,

CA.


49. West NA, Lynch AM, Hart JE, Streubel AH, McDuffie RS. Changing trends in

intrauterine growth. Poster presentation. SMFM's 33rd Annual Meeting, February 2013,

San Francisco, CA.

50. Reynolds PR, Giclas P, Lynch AM, Myers L, Marola J, Ramamoorthy P. Analysis of

the Complement Pathway Exome with Next Generation Sequencing. Poster presentation.

Association for Molecular Pathology 2013 Annual Meeting Phoenix, Az, 2013

51. Schisterman E, Lynch AM, EAGeR Group. Randomized clinical trial of preconception

low dose aspirin use to improve pregnancy outcomes: EAGeR (Effects of Aspirin in

Gestation and Reproduction) Trial. Podium presentation, SMFM's 33rd Annual Meeting,

February 2013, San Francisco, CA.

52. Ahrens K, Silver RM, Perkins NJ, Wong L, Galai N, Lesher LL, Faraggi D, Wactawski-

Wende J, Townsend JM, Lynch AM, Mumford SL, Schisterman EF. Preconception Low

Dose Aspirin and Preterm Birth: Findings from the EAGeR (Effects of Aspirin in

Gestation and Reproduction) Randomized Trial. Oral presentation, SMFM 34th Annual

Meeting New Orleans, Concurrent Session 1 February 6, 2014

53. Post A, Moore G, Lynch A, West N, Gibbs R. Timing of 3rd trimester ultrasound for

birth weight prediction in diabetic pregnancies. Poster # number 273 presentation SMFM

34th Annual New Orleans, 2014.

54. Hauk P, Schwartz D, Lynch AM, Winn V, Strand M, Munoz L, Gelfend E. Differential

DNA Methylation in Mothers increases the prevalence of atopic dermatitis in their

offspring (oral presentation and Poster Number: 522). 2014 AAAAI Annual Meeting,

February 28, to March 4, 2014 San Diego, CA.

55. Ahrens KA, Silver RM, Perkins NJ, Galai N, Lesher LL, Faraggi D, Wactawski-Wende J,

Townsend JM, Lynch AM, Mumford SL, Schisterman EF. Preconception low dose

aspirin and adverse events: findings from the EAGeR (Effects of Aspirin in Gestation and

Reproduction) randomized trial. Poster presentation. 27th Annual Meeting of the Society

for Pediatric and Perinatal Epidemiologic Research (SPER), Seattle, WA, June 23-24,

2014

56. Schliep KC, Wong LF, Schisterman EF, Wactawski-Wende J, Townsend JM, Lynch

AM, Galai N, Faraggi D, Perkins NJ, Mumford SL, Ye A, Silver RM. How long after a

miscarriage should women wait before trying to become pregnant again? Oral

presentation at the Concurrent Contributed Session, Fecundability: Novel Methods and

Findings at the 47th Annual Society for Epidemiologic Research Meeting, June 2014,

Seattle, WA.

57. Matyas RA, Lesher LL, Newman SL, Silver RM, Galai N, Hovey K, Wactawski-Wende

J, Emerick L, Lynch AM, Mead B, Townsend JM, Perkins NJ, Mumford SL,

Schisterman ES. Recruitment for longitudinal pregnancy studies initiated preconception:

lessons learned from the EAGeR Trial. Poster at the 27th Annual Meeting of the Society

for Pediatric and Perinatal Epidemiologic Research (SPER), Seattle, WA, June 23-24,

2014


58. Cao JH, MD, Wagner BD, McCourt EA, Cerda A1, MPH, Sillau S, Enzenauer RW.

Mets-Halgrimson RB, Paciuc-Beja M, Gralla J, PhD, Braverman RS, Lynch AM.

Colorado Retinopathy of Prematurity Model: Post Natal Weight Gain Screening

Algorithm. Podium presentation. AAPOS, Rancho Mirage, CA, 2014.

59. Wong LF, Schliep KC, Silver RM, Mumford SL, Perkins NJ, Ye A, Gali N, Wactawski-

Wendi J, Lynch AM, Townsend JM, Faraggi D, Schisterman EF. The effect of very

short interpregnancy interval on pregnancy outcomes following a previous pregnancy

loss. Presented in part as a poster at the Society for Maternal-Fetal Medicine 34th Annual

Meeting, Hilton New Orleans Riverside, New Orleans, Louisiana, USA, February 3-8,

2014 (final abstract ID# 412)

60. Mumford SL, Schisterman EF, Lesher L, Faraggi D, Wactawski-Wende J, Townsend J,

Lynch AM, Perkins NJ, Galai N, Silver RM. Randomized clinical trial of preconception

low dose aspirin use and pregnancy loss: EAGeR (Effects of Aspirin in Gestation and

Reproduction) trial. Poster at the 27th Annual Meeting of the Society for Pediatric and

Perinatal Epidemiologic Research (SPER), Seattle, WA, June 23-24, 2014.

61. Zarek SV, Schisterman EF, Mitchell EM, Lynch AM, Faraggi D, Mumford SL. Is anti-

mullerian hormone (AMH) associated with preterm birth? Results from the effects of

aspirin in gestation and reproduction (EAGeR) trial. Poster Number: P-395, Wednesday,

October 22, 2014, Session Topic: Reproductive Hormones ASRM. Fertility and Sterility,

Vol. 102, Issue 3, e269. Published in issue: September 2014

62. Starling AP, Brinton JT, Glueck DH, Harrod CS, Lynch AM, Siega-Riz AM, Dabelea D..

Associations of maternal body mass index and gestational weight gain with neonatal

adiposity in the Healthy Start Study. Podium presentation, Obesity Society annual

meeting in Boston on November 4-7, 2014.

63. Cao JH, Cerda AM, Lynch AM, Wong RK, Gore C, MD. Puente MA, Morrison DG,

McCourt EA. Colorado ROP Screening Model: A Multi-Institutional Validation Study.

Podium presentation AAPOS New Orleans, LA, 2015

64. Jung J, Cao JH, Lynch AM, Braverman R, Rebecca Braverman, MD, Robert Enzenauer,

MD, McCourt EA. Validation of WINROP for Detecting High-Grade Retinopathy of

Prematurity in Colorado Preterm Infants. Podium presentation. AAPOS New Orleans

2015.

65. Radin RG, Mumford SL, Silver R, Lesher L, Galai N, Faraggi D, Wactawski-Wende J,

Townsend JM, Lynch AM, Simhan HN, Sjaarda L, Perkins N, Zarek S, Plowden T,

Mitchell E, Michels K, Schliep K, Kalwerisky R, Schisterman EF. Pre-conception low-

dose aspirin and sex ratio: the EAGeR trial. Podium presentation at the 28th Annual

Meeting of the Society for Pediatric and Perinatal Epidemiologic Research (SPER),

Denver, CO June 15-16, 2015.

66. Sjaarda LA, Mitchell E, Mumford SL, Radin R, Zarek S, Schliep K, Plowden T, Michels

K, Kalwerisky R, Perkins N, Stanford J, Wactawski-Wende J, Townsend J, Lynch A,

Lesher L, Faraggi D, Galai N, Silver R, Schisterman EF. The effects of preconception


low dose aspirin treatment on clinical pregnancy and live birth according to inflammatory

status. Podium presentation at the 28th Annual Meeting of the Society for Pediatric and

Perinatal Epidemiologic Research (SPER), Denver, CO June 15-16, 2015.

67. Zarek SM, Mitchell EM, Sjaarda LA, Silver RM, Wactawski-Wende J, Townsend JM,

Lynch AM, Lesher LL, Stanford JB, Galai N, Faraggi D,. Schliep KC, Plowden TC,

Radin RG, Kalwerisky RA, Perkins NJ, DeCherney AH, Mumford SL, Schisterman EF.

Anti-mullerian hormone is not associated with fecundability. Poster presentation at the

28th Annual Meeting of the Society for Pediatric and Perinatal Epidemiologic Research

(SPER), Denver, CO June 15-16, 2015.

68. Zarek SM, Mitchell EM, Sjaarda LA, Silver RM, Wactawski-Wende J, Townsend JM,

Lynch AM, Lesher LL, Stanford JB, Galai N, Faraggi D,. Schliep KC, Plowden TC,

Radin RG, Kalwerisky RA, Perkins NJ, DeCherney AH, Mumford SL, Schisterman EF.

Anti-mullerian hormone is not associated with pregnancy loss. Poster presentation at the

28th Annual Meeting of the Society for Pediatric and Perinatal Epidemiologic Research

(SPER), Denver, CO June 15-16, 2015

69. Plowden TC, Schisterman RF, Ye A, Sjaarda L, Perkins NJ, Zarek S, Schliep K,

Kalwerisky R, Wactawski-Wende J, Townsend J, Lynch A, Silver R, Lesher L, Galai N,

Faraggi D, Radin R, Mitchell E, Michels K, DeCherney AH, Mumford S. Association

between Thyroid-Stimulating Hormone (TSH) and pregnancy loss. Poster presentation at

the 28th Annual Meeting of the Society for Pediatric and Perinatal Epidemiologic

Research (SPER), Denver, CO June 15-16, 2015

70. McCourt, EA, Kim, YC, Cerda, A, Singh, J Wagner, B Jung, J, Cao J, Braverman R,

Enzenauer R, Lynch A. Relationship between Maternal Race/Ethnicity and Retinopathy

of Prematurity in a Colorado Cohort. Poster presentation at ARVO Denver CO, 2015.

71. Singh J, Cerda A, Wagner B, McCourt EA, Cao JH, Jung J, Braverman RS. Enzenauer

RW, Lynch AM. Risk for Retinopathy of Prematurity in Singletons versus Twins in a

Colorado Cohort. Poster presentation at ARVO Denver CO 2015.

72. Cheroff A, Cerda A, Wagner B, Lynch A, Gregory D. Acute Stevens-Johnson syndrome:

The effect the timing of amniotic membrane transplantation has on the occurrence of

significant ocular sequelae. Podium presentation. 18th Annual IOSS meeting held at

Warwick Denver Hotel 1776 Grant Street Denver, CO 80203 USA May 2, 2015.

73. Wagner BD, Deterding RR, Abman SA, Lynch A, Mourani PA, DeBoer EM, Harris JK,

Kroehl M. Identification of biomarkers using SomaLogic aptamers. The power of

informatics to advance health. Podium presentation 2nd Annual Mini-Symposium.

University of Colorado, Anschutz Medical Campus April 10, 2015 *

74. Zarek S, Plowden T, Mumford S, Radin R, Schisterman E, Sjaarda L, Perkins N, Mitchell

E, Schliep K, Kalwerisky R, Michels K, Wactawski-Wende J, Townsend J, Lynch A,

Lesher L, Faraggi D, Galai N, Silver R. Is anti-mullerian hormone associated with

preterm birth? Poster presentation. SPER, Denver, CO, 2015.


75. Rodríguez-Colón G, Cerda A, McCourt E, Cerda A, Hink E, Lynch AM. Assessment of

eye disease in patients with Nasolacrymal Duct Obstruction (NLDO). Presented

(podium) at the 19th Annual Ophthalmology Resident, Fellow, Faculty and Alumni

Research Day. June 20, 2015, Aurora Colorado. *

76. Cherof A. Cerda A, Lynch A, Wagner B, Gregory G. Acute Stevens-Johnson Syndrome:

Amniotic membrane transplantation and occurrence of significant ocular sequelae.

Presented (podium) at the 19th Annual Ophthalmology Resident, Fellow, Faculty and

Alumni Research Day. June 20, 2015, Aurora Colorado. *

77. Jung J, Cao JH, Lynch AM, Braverman R, Rebecca Braverman, MD, Robert Enzenauer,

MD, McCourt EA. Validation of WINROP for Detecting High-Grade Retinopathy of

Prematurity in Colorado Preterm Infants. Presented (podium) at the 19th Annual

Ophthalmology Resident, Fellow, Faculty and Alumni Research Day. June 20, 2015,

Aurora Colorado. *

78. Salmon JE, Kim MY, Guerra MM, Kaplowitz E, Laskin CA, Petri M, Branch DW,

Lockshin MD, Sammaritano LR, Merrill JT, Stephenson MD, Khamashta M. Peaceman

AM, Lynch AM and Buyon JP. Complement Activation Predicts Adverse Pregnancy

Outcome in Patients with SLE and/or aPL Antibodies. Podium presentation, American

College of Rheumatology meeting, San Francisco, CA. 2015.

79. Cherof A, Cerda A, Lynch A, Wagner B, Gregory G. Acute Stevens - Johnson

syndrome: Timing of amniotic membrane transplantation and occurrence of significant

ocular sequelae. Podium Presentation at the American Academy of Ophthalmology

Conference 2015. Las Vegas, Nevada. Award received for best paper.

80. Mumford S, Plowden T, Mumford S, Radin R, Schisterman E, Sjaarda L, Perkins N,

Zarek S, Mitchell E, Schliep K, Kalwerisky R, Michels K, Wactawski-Wende J,

Townsend J, Lynch A, Lesher L, Faraggi D, Galai N, Silver R. Vitamin D and Ovarian

Reserve and Fecundability among Women with Proven Fecundity. Poster presentation

American Society for Nutrition Meeting, April 2-6, 2016, San Diego, CA 2016, San

Diego, CA

81. Mumford S, Plowden T, Mumford S, Radin R, Schisterman E, Sjaarda L, Perkins N,

Zarek S, Mitchell E, Schliep K, Kalwerisky R, Michels K, Wactawski-Wende J,

Townsend J, Lynch A, Lesher L, Faraggi D, Galai N, Silver R. Vitamin D and ovarian

reserve among women with proven fecundity. Poster presentation, Society for Pediatric

and Perinatal Epidemiologic Research, Miami, FL, June 21-24, 2016.

82. Wildes M, Cherof AM, Cerda A, Lynch AM, Wagner, Gregory D. Outcomes of amniotic

membrane transplantation for treatment of Stevens-Johnson syndrome in the pediatric

population: A retrospective review. Poster presentation AAPOS 2016, Vancouver,

Canada.

83. Singh J, Lynch AM, Cao J, McCourt E, Wagner B, Jung J, Braverman R. Validation of

the Colorado Retinopathy of Prematurity model for detecting ROP in an expanded

Colorado cohort. Poster presentation AAPOS 2016, Vancouver, Canada.


84. Cerda AM, Mathias M, Lynch AM, Wagner BD, Siringo F, Bonnell LN, Mandava N.

The Relationship of Chronic Hypertension with Geographic Atrophy and Neovascular-

Age Related Macular Degeneration in a Colorado Cohort. Poster presentation ARVO

2016, Seattle, WA.

85. Bonnell LN, SooHoo JR, Seibold LK, Lynch AM, Wagner BD, Davidson RS, Taravella

MJ. One-day postoperative intraocular pressure spikes after phacoemulsification cataract

surgery in patients taking Tamsulosin. Poster presentation ARVO 2016, Seattle, WA.

Award winning poster.

86. Cao JH, Cerda AM, Lynch AM, Wong RK, Gore C, MD. Puente MA, Morrison DG,

McCourt EA. Colorado ROP Screening Model: A Multi-Institutional Validation Study.

Podium presentation. AAO 2015 Original Paper Session: OP08 Pediatric

Ophthalmology, Strabismus Original Papers and Best of AAPOS. November 16, 2015,

Las Vegas Nevada.

87. Manoharan N, Bonnell LN, Lynch A, Seibold L. Refractive Outcomes of Cataract

Surgery in Glaucoma Patients. Poster presentation ASCRS, New Orleans, May 2016.

88. Alexander J, Bonnell LN, Lynch A, Taravella M. To determine the cost of managing

posterior capsular tears (PCT’s) to both the hospital system and to patients and their

insurers. Poster and podium presentation. ASCRS, New Orleans, May 2016. Best poster

award.

89. Tawse KL, Cerda AM, Lynch AM, Wagner BD, Wymore EM, Jung JL, Braverman RS,

Singh J, McCourt EA, Enzenauer RW Infant Race/Ethnicity as a risk factor for Type 1

ROP in a Colorado Cohort. Poster presentation, AAPOS, Vancouver, Canada, April 2016

90. McCourt EA, Lynch AM, Wagner BD, Cerda AM, Jung JL, Wymore EM, Singh J,

Enzenauer RW, Braverman RS Validation of the CHOP model for detecting high-grade

retinopathy of prematurity in a cohort of Colorado infants. Podium presentation AAPOS,

Vancouver, Canada, April 2016

91. Pugh SJ, Schisterman EF, Perkins N, Mumford S, Sjaarda L, Browne RW, Silver R,

Wactawski-Wende J, Galai N, Stanford J, Wilcox B, Lynch A. Maternal Lipids and Time

to Pregnancy. Society for Pediatric and Perinatal Epidemiologic Research, Miami, FL,

June 2016.

92. Mumford SL, Silver RM, Sjaarda LA, Gali N, Lynch A, Perkins NJ, Eactawski-Wende J,

Keewan K, Michels K, Schisterman EF. Vitamin D and ovarian reserve among women

with proven fecundity. Poster presentation Society for Pediatric and Perinatal

Epidemiologic Research, Miami, FL, June 2016.

93. Radin RG, Mumford SL, Sjaarda LA, Silver RM, Galai N, Faraggi D, Wactawski-Wende

J Townsend JM. Lynch AM, Perkins NJ, Lesher LL. Plowden TC, Hinkle SN, Kim K,

Schisterman EF. Preconception attempted and actual weight change in relation to

pregnancy loss. Honorable mention at the SPER poster session. FL, June 2016.


94. Capitena C, Corbett D, Cerda A, SooHoo JR, Pantcheva M, Kahook M, Lynch AM,

Seibold LK. Poster presentation at the 27th American Glaucoma Society (AGS) Annual

Meeting, March 2-5, 2017, Coronado, Ca.

95. Lynch AM, Wagner BD, Hodges J, Thevarajah T, McCourt EA, Cerda A, Gibbs R,

Palestine AG. The Relationship between the Antecedents of Preterm Birth with

Retinopathy of Prematurity. Poster presentation. AAPOS 43rd Annual Meeting, April 2

– 6, 2017, Nashville, TN. Award winning poster.

96. Cerda A, Wagner BD, Lynch AM, Jung JL, Wymore E, Singh JK, Enzenauer RE,

McCourt EA. The Use of The Fenton Preterm Growth Chart and Z-scores as Growth

Parameters in Assessing the Risk of Retinopathy of Prematurity. Poster presentation.

AAPOS 43rd Annual Meeting, April 2 – 6, 2017, Nashville, TN.

97. Mc Court EA, Ying Gui-shuang, Lynch AM, Cerda A, Wagner B, Wymore E,

Tomlinson L Binenbaum G. Validation Study of the Colorado Model for Predicting ROP.

Poster presentation. AAPOS 43rd Annual Meeting, April 2 – 6, 2017, Nashville, TN

98. Braverman RS, Mc Court EA, Cerda A, Singh J, Wagner BD, Jung JL, Enzenauer RW,

Thevarajah T, Lynch AM High rate of strabismus in a cohort of infants screened for

ROP. Poster presentation. AAPOS 43rd Annual Meeting, April 2 – 6, 2017, Nashville,

TN

99. Wildes MT, Bonnell LN, Lynch AM, Taravella MJ. Utility of routine 1-2-week

postoperative review for detecting early complications after phacoemulsification cataract

surgery. Poster presentation ASCRS Symposium on Cataract, IOL and Refractive

Surgery. May 5-9, 2017, Los Angeles, CA

100. Wise RE, Bonnell LN, Lynch AM, Taravella M. Evaluating the Risk of a Prior Pars

Plana Vitrectomy with Adverse Intraoperative events during Cataract Surgery. ASCRS

Symposium on Cataract, IOL and Refractive Surgery. May 5-9, 2017, Los Angeles, CA.

101. Bonnell LN, Lynch AM, Petrash M, Wagner BD, Davidson RS, Taravella M. Posterior

capsule tears during phacoemulsification cataract surgery among patients with a

diagnosis of type II diabetes mellitus. Poster presentation. ASCRS Symposium on

Cataract, IOL and Refractive Surgery. May 5-9, 2017, Los Angeles, CA.

102. Brunin G, Bonnell, LN, Lynch AM, Taravella M, Davidson R. Comparing YAG

Capsulotomy Rates Between Femtosecond Laser-Assisted and Manual

Phacoemulsification Cataract Surgery. Poster presentation ASCRS Symposium on

Cataract, IOL and Refractive Surgery. May 5-9, 2017, Los Angeles, CA.

103. Petty ST, Bonnell, LN, Lynch AM, Petty JS. Assessing the Changes in Relative

Humidity over the Cornea, Using 3 Different Eyeglass Frame Designs. Poster

presentation. ASCRS Symposium on Cataract, IOL and Refractive Surgery. May 5-9,

2017, Los Angeles, CA


104. Nagaraj RH, Rakete S, Rankenberg J, Bonnell L, Wagner B, Lynch A, Henning C

Glomb MA. Advanced Glycation Endproducts in capsulorhexis specimen: Correlation

with Diabetic Retinopathy. Poster presentation. ARVO. May 7-11, 2017, Baltimore Md.

105. Wymore E, Singh J, Thevarajah T, Hodges J, Wagner B, Kinsella J, Lynch AM. The

relationship between severe hypertensive diseases of pregnancy and moderate-severe

bronchopulmonary dysplasia. Poster Presentation PAS meeting. May 2017, San

Francisco, CA.

106. Keewan Kim, Schisterman EF, Silver RM, Wilcox BD, Lynch AM, Perkins NJ, Browne

RW, Lesher LL, Stanford JB, Ye A, Wactawski-Wende J, Mumford SL. Fat soluble

micronutrients and time to pregnancy. Poster presentation SPER, Seattle, Washington,

June 19-20, 2017.

107. Nagaraj R Rakete Stefan1, Rankenberg J Bonnell L, Wagner B, Lynch A, Henning C,

Glomb M. Advanced Glycation Endproducts in capsulorhexis specimen: Correlation

with Diabetic Retinopathy. Poster Presentation ARVO 2017 Annual Meeting May 7 –

11, 2017 Baltimore, Maryland.

108. Siringo FS, Manoharan N, Palestine A, Oliver SCN, Mathias MM, Olson J, Smith JM,

Pecen P, Lindt MC, Wagner BD, Lynch AM, Mandava N. Silicone oil endotamponade

in primary retinal detachment: a novel risk factor for proliferative vitreoretinopathy?

Paper on demand. ASRS Annual Meeting August 11-15, 2017 Boston MA.

* non-competing abstract

Documents

CURRICULUM VITAE Anne M. Lynch, MB, BCh, BAO, … · 1983 Diploma in Obstetrics (DObst), ... 2010 Assistant Professor, Preventive Medicine and Biometrics, Department of ... Seminar,