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July 1, 2019

CURRICULUM VITAE

Ani W. Manichaikul

Center for Public Health Genomics Department of Public Health Sciences University of Virginia P.O. Box 800717 Charlottesville, VA 22903 Phone: 434-982-1612 Fax: 434-982-1815 Email: amanicha@virginia.edu Web: http://people.virginia.edu/~am3xa/ EDUCATION

2008 – 2009 Postdoc, Computational Systems Biology Laboratory, Department of Biomedical Engineering, University of Virginia (Advisor: Jason A. Papin)

2008 PhD, Biostatistics, Johns Hopkins University (Advisor: Karl W. Broman;

thesis: Statistical methods for mapping quantitative trait loci in experimental crosses)

2003 MS, Statistics, Stanford University 2003 BS, Mathematics, Stanford University

PROFESSIONAL POSITIONS

2019 – pres. Associate Professor, Center for Public Health Genomics and Biostatistics Section, Department of Public Health Sciences, University of Virginia

2019 – pres. Associate Professor, Department of Biochemistry and Molecular Genetics,

University of Virginia 2011 – 2019 Assistant Professor, Center for Public Health Genomics and Biostatistics

Section, Department of Public Health Sciences, University of Virginia 2009 – 2011 Instructor, Center for Public Health Genomics and Division of Biostatistics and

Epidemiology, Department of Public Health Sciences, University of Virginia

OTHER RESEARCH EXPERIENCE

2007 – 2009 Statistical Genetics Consultant, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, MD

Summer 2004 Intern, Non-clinical Statistics, Pfizer Global Research and Development, Ann

Arbor, MI

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2001, 2003 Programmer Analyst, Diabetes Prevention Program, George Washington University Biostatistics Center, Rockville, MD

Summer 2000 Intern, Computational Chemistry Group, National Institute of Standards and

Technology, Gaithersburg, MD 1998 – 1999 Research Trainee, Laboratory of Molecular Biology, National Institute on

Deafness and Other Communication Disorders, Rockville, MD HONORS AND AWARDS 2019 Montgomery Blair High School Distinguished Alumni Award 2016 Multi-Ethnic Study of Atherosclerosis (MESA) Early Career Investigator Award 2004-2007 National Science Foundation Graduate Research Fellowship 2006 First place, Delta Omega Poster Competition, Johns Hopkins Biostatistics 2003-2004 Epidemiology and Biostatistics of Aging Training Grant EDITORIAL ACTIVITIES Peer Review Activities Referee for American Journal of Human Genetics; American Journal of Respiratory and Critical Care Medicine; Annals of the American Thoracic Society; Bioinformatics; Biometrics; Biophysical Journal; BMC Bioinformatics; BMC Genetics; BMC Systems Biology; Circulation; Diabetes Care; European Respiratory Journal; Genetic Epidemiology; Heredity; Journal of the American College of Cardiology; Journal of Cardiovascular and Translational Research; Journal of Clinial Endocrinology and Metabolism; Journal of Computational and Graphical Statistics; Journal of Heredity; Physiological Genomics; PLoS Genetics; PLoS One; Statistical Applications in Genetics and Molecular Biology; and Statistics and Probability Letters Grant Review Activities 2019 Ad hoc grant review for NIH Neurotoxicology and Alcohol (NAL) Study Section 2018 Ad hoc grant review for NIH/NHLBI Special Emphasis Panel for RFA HL18-024,

“Cardiovascular and Pulmonary Research on E-Cigarettes” 2018 Review for American Heart Association Fellowship Program 2017 – pres. Alpha-1 Foundation Grants Advisory Committee member 2015 Review for Alpha-1 Foundation/American Lung Association Research Grant program 2012 Ad hoc grant review for The Netherlands Organisation for Health Research and

Development (ZonMw) Investment Programme PUBLICATIONS Peer-reviewed Articles Authors from Dr. Manichaikul’s group are marked as follows: # denotes equally contributing lead authors ‡ denotes equally contributing corresponding authors * denotes corresponding author Staff under supervision of Dr. Manichaikul are underlined 1. Grant DJ, Manichaikul A, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML,

Funkhouser E, Moorman PG, Peres LC, Peters ES, Schwartz AG, Terry PD, Wang XQ, … [70 authors] …, Song H, Campbell I, Eccles D, DeFazio A, Kennedy CJ, Schildkraut JM. Evaluation of

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vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women. Cancer Med. 2019 Apr 18. doi: 10.1002/cam4.1996. [Epub ahead of print] Dr. Manichaikul performed and supervised the genetic analysis of epithelial ovarian cancer.

2. Oelsner EC, Ortega VE, Smith BM, Nguyen JN, Manichaikul AW, Hoffman EA, Guo X, Taylor KD,

Woodruff PG, Couper DJ, Hansel NN, Martinez FJ, Paine Iii R, Han MK, Cooper C, Dransfield MT, Criner G, Krishnan JA, Bowler R, Bleecker ER, Peters S, Rich SS, Meyers DA, Rotter JI, Barr RG. A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography. Am J Respir Crit Care Med. 2019 Mar 29. doi: 10.1164/rccm.201812-2355OC. [Epub ahead of print]

Dr. Manichaikul’s group computed the COPD genetic risk score in MESA and contributed to interpretation of results.

3. de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, … [133 authors] …,

Manichaikul AW, … [122 authors] …, Munroe PB, Rice K, Chasman DI, Cupples LA, Rao DC, Morrison AC. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. Am J Epidemiol. 2019 Jan 29. doi: 10.1093/aje/kwz005. [Epub ahead of print]

Dr. Manichaikul contributed to genetic analysis of lipid levels in MESA.

4. Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE,

Dedoussis GV, Lemaitre RN, Wojczynski MK, Männistö S, Ngwa JS, Kho M, Ahluwalia TS, Pervjakova N, Houston DK, Bouchard C, Huang T, Orho-Melander M, Frazier-Wood AC, Mook-Kanamori DO, Pérusse L, Pennell CE, de Vries PS, Voortman T, Li O, Kanoni S, Rose LM, Lehtimäki T, Zhao JH, Feitosa MF, Luan J, McKeown NM, Smith JA, Hansen T, Eklund N, Nalls MA, Rankinen T, Huang J, Hernandez DG, Schulz CA, Manichaikul A, … [57 authors] …, Florez JC, Deloukas P, Lyytikäinen LP, Chasman DI, Chu AY, Tanaka T. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. 2018 Jul 9. [Epub ahead of print]

Dr. Manichaikul contributed to genetic analysis of macronutrient intake in MESA.

5. Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, … [157 authors] …,

Manichaikul AW, … [134 authors] …, Rice K, Munroe PB, Morrison AC, Rao DC, Rotimi CN, Cupples LA. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019 Apr;51(4):636-648.

Cited 0 times, IF= 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul contributed to genetic analysis of lipid levels in MESA.

6. Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N,

Qiao D, … [37 authors] …, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH; SpiroMeta Consortium; International COPD Genetics Consortium. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 Mar;51(3):494-505.

Cited 1 time, IF= 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul’s group performed the genome-wide association analysis of COPD in MESA.

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7. Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, Patchen BK, Schu M, Beydoun MA, Brusselle GG, Eiriksdottir G, Zhou X, Wood AC, Graff M, Harris TB, Ikram MA, Jacobs DR Jr, Launer LJ, Lemaitre RN, O'Connor G, Oelsner EC, Psaty BM, Ramachandran VS, Rohde RR, Rich SS, Rotter JI, Seshadri S, Smith LJ, Tiemeier H, Tsai MY, Uitterlinden AG, Voruganti VS, Xu H, Zilhão NR, Fornage M, Zillikens MC, London SJ, Barr RG, Dupuis J, Gharib SA, Gudnason V, Lahousse L, North KE, Steffen LM, Cassano PA, Hancock DB. Omega-3 Fatty Acids and Genome-wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2019 Mar 1;199(5):631-642.

Cited 1 time, IF= 14.53, Rank 2 of 60 Respiratory System Journals. Dr. Manichaikul performed the genome-wide interaction analysis of omega-3 fatty acids for the outcome of pulmonary function in MESA.

8. Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, … [107 authors] …,

Manichaikul A, … [110 authors] …, Fornage M, Cupples LA, Rotimi CN, Morrison AC, Rao DC, Loos RJF. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun. 2019 Jan 22;10(1):376.

Dr. Manichaikul contributed to genetic analysis of lipid levels in MESA.

9. Prokopenko D, Sakornsakolpat P, Fier HL, Qiao D, Parker MM, McDonald MN, Manichaikul A,

Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH. Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 Nov;59(5):614-622.

Cited 3 times, IF= 4.12, Rank 15 of 60 Respiratory System Journals. Dr. Manichaikul performed analysis of selected genetic variants in relation to alpha-1 antitrypsin levels in the MESA participants.

10. Xu J, Bartz TM, Chittoor G, Eiriksdottir G, Manichaikul AW, Sun F, Terzikhan N, Zhou X, Booth

SL, Brusselle GG, de Boer IH, Fornage M, Frazier-Wood AC, Graff M, Gudnason V, Harris TB, Hofman A, Hou R, Houston DK, Jacobs DR, Kritchevsky SB, Latourelle J, Lemaitre RN, Lutsey PL, O'Connor G, Oelsner EC, Pankow JS, Psaty BM, Rohde RR, Rich SS, Rotter JI, Smith LJ, Stricker BH, Voruganti VS, Wang TJ, Zillikens MC, Barr RG, Dupuis J, Gharib SA, Lahousse L, London SJ, North KE, Smith AV, Steffen LM, Hancock DB, Cassano PA. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. Br J Nutr. 2018 Nov;120(10):1159-1170.

Cited 1 time, IF= 4.05, Rank 23 of 83 Nutrition and Dietetics Journals. Dr. Manichaikul performed the analysis of serum vitamin D with pulmonary function in MESA.

11. Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny

NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A. Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease. PLoS One. 2018 Oct 5;13(10):e0204352.

Cited 0 times, IF= 3.35, Rank 15 of 64 Multidisciplinary Sciences Journals.

12. Natarajan P, Peloso GM, Zekavat SM, Montasser M, Ganna A, Chaffin M, Khera AV, Zhou W,

Bloom JM, Engreitz JM, Ernst J, O'Connell JR, Ruotsalainen SE, Alver M, Manichaikul A, Johnson WC, Perry JA, Poterba T, Seed C, Surakka IL, Esko T, Ripatti S, Salomaa V, Correa A,

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Vasan RS, Kellis M, Neale BM, Lander ES, Abecasis G, Mitchell B, Rich SS, Wilson JG, Cupples LA, Rotter JI, Willer CJ, Kathiresan S; NHLBI TOPMed Lipids Working Group. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018 Aug 23;9(1):3391.

Cited 6 times, IF= 13.69, Rank 3 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul contributed to phenotype harmonization of lipids traits in MESA.

13. Wyss AB#, Sofer T#, Lee MK#, Terzikhan N#, Nguyen JN#, Lahousse L#, Latourelle JC, Smith

AB, Bartz TM, Feitosa MF, Gao W, Ahluwalia TS, Tang, W Oldmeadow C, Duan Q, de Jong K, Wojczynski MK, Wang XQ, Noordam R, … [56 authors] …, Kim WJ, Attia JR, Lange L, Boezen HM, Thyagarajan B, Rich SS, Mook-Kanamori DO, Horta BL, Uitterlinden AG, Sin DD, Im HK, Cho MH, Brusselle GG‡, Gharib SA‡, Dupuis J‡, Manichaikul A‡, London SJ‡. Multiethnic meta-analysis identifies new loci for pulmonary function. Nat Commun. 2018 Jul 30;9(1):2976. Cited 4 times, IF= 13.69, Rank 3 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul’s group performed genome-wide association analysis of pulmonary function in MESA. We further performed integrative genomic analysis to combine the Genome-Wide Association Study (GWAS) results with publically available gene expression data

14. Burkart KM, Sofer T, London SJ, Manichaikul A, Hartwig FP, Yan Q, Soler Artigas M, Avila L,

Chen W, Thomas SD, Diaz AA, Hall IP, Horta BL, Kaplan RC, Laurie CC, Menezes AM, Morrison JV, Oelsner EC, Rastogi D, Rich SS, Soto-Quiros M, Stilp AM, Tobin MD, Wain LV, Celedón JC, Barr RG. A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med. 2018 Jul 15;198(2):208-219.

Cited 5 times, IF= 14.53, Rank 2 of 60 Respiratory System Journals. Dr. Manichaikul performed replication analysis of selected genetic variants for pulmonary function in MESA.

15. Zekavat SM, Ruotsalainen S, Handsaker RE, Alver M, Bloom J, Poterba T, Seed C, Ernst J,

Chaffin M, Engreitz J, Peloso GM, Manichaikul A, Yang C, Ryan KA, Fu M, Johnson WC, Tsai M, Budoff M, Vasan RS, Cupples LA, Rotter JI, Rich SS, Post W, Mitchell BD, Correa A, Metspalu A, Wilson JG, Salomaa V, Kellis M, Daly MJ, Neale BM, McCarroll S, Surakka I, Esko T, Ganna A, Ripatti S, Kathiresan S, Natarajan P; NHLBI TOPMed Lipids Working Group. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 Jul 4;9(1):2606.

Cited 7 times, IF= 13.69, Rank 3 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul’s group computed the lipoprotein(a) risk score for participants in MESA and examined the relationship with measures of subclinical atherosclerosis

16. Oelsner EC, Smith BM, Hoffman EA, Kalhan R, Donohue KM, Kaufman JD, Nguyen JN,

Manichaikul AW, Rotter JI, Michos ED, Jacobs DR Jr., Burke GL, Folsom AR, Schwartz JE, Watson K, Barr RG. Prognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population: The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Ann Am Thorac Soc. 2018 Jun;15(6):718-727.

Cited 4 times, IF= 4.01, Rank 13 of 60 Respiratory System Journals. Dr. Manichaikul’s group computed the COPD genetic risk score that was used to examine association with selected outcomes in this study.

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17. de Oliveira Otto MC, Lemaitre RN, Sun Q, King IB, Wu JHY, Manichaikul A, Rich SS, Tsai MY, Chen YD, Fornage M, Weihua G, Aslibekyan S, Irvin MR, Kabagambe EK, Arnett DK, Jensen MK, McKnight B, Psaty BM, Steffen LM, Smith CE, Risérus U, Lind L, Hu FB, Rimm EB, Siscovick DS, Mozaffarian D. Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium. PLoS One. 2018 May 8;13(5):e0196951.

Cited 0 times, IF= 3.35, Rank 15 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul completed the genome-wide association analysis of odd-numbered chain saturated fatty acids in MESA.

18. Oelsner EC, Smith BM, Hoffman EA, Folsom AR, Kawut SM, Kaufman JD, Manichaikul A,

Lederer DJ, Schwartz JE, Watson KE, Enright PL, Austin JHM, Lima JAC, Shea SJ, Barr RG. Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax. 2018 May;73(5):486-488.

Cited 1 time, IF= 8.61, Rank 5 of 60 Respiratory System Journals. Dr. Manichaikul’s group computed the COPD genetic risk score that was used to examine association with selected outcomes in this study.

19. Peres LC, Risch H, Terry KL, Webb PM, Goodman MT, Wu AH, Alberg AJ, Bandera EV,

Barnholtz-Sloan J, Bondy ML, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Manichaikul A, Abbott SE, Camacho F, Jordan SJ, Nagle CM; Australian Ovarian Cancer Study Group, Rossing MA, Doherty JA, Modugno F, Moysich K, Ness R, Berchuck A, Cook L, Le N, Brooks-Wilson A, Sieh W, Whittemore A, McGuire V, Rothstein J, Anton-Culver H, Ziogas A, Pearce CL, Tseng C, Pike M, Schildkraut JM; African American Cancer Epidemiology Study and the Ovarian Cancer Association Consortium. Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol. 2018 Apr 1;47(2):460-472.

Cited 5 times, IF= 10.18, Rank 5 of 181 Public, Environmental and Occupational Health Journals. Dr. Manichaikul provided guidance for the interpretation of genetic ancestry for this study.

20. Sakornsakolpat P, Morrow JD, Castaldi PJ, Hersh CP, Bossé Y, Silverman EK, Manichaikul A,

Cho MH. Integrative genomics identifies new genes associated with severe COPD and emphysema. Respir Res. 2018 Mar 22;19(1):46.

Cited 5 times, IF= 4.11, Rank 17 of 60 Respiratory System Journals. Dr. Manichaikul provided guidance for integration of genomic and transcriptomic data resources in this study.

21. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese

AK, van der Laan SW, … [67 authors] …, Manichaikul A, … [174 authors] …, Debette S, Dichgans M; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium; MEGASTROKE Consortium. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018 Apr;50(4):524-537.

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Cited 54 times, IF= 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed genome-wide association analysis of stroke outcomes using Cox regression models in the MESA study for this meta-analysis effort.

22. Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV,

Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR Jr., Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG; MESA Lung and SPIROMICS investigators. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E974-E981.

Cited 8 times, IF= 10.36, Rank 5 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul’s group performed replication analysis of select genetic variants for human airway branch traits in the SPIROMICS study.

23. Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA,

Gao W, Qaiser B, Porteous DJ, Cassano PA, Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B; Understanding Society Scientific Group, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018 Jan 12;3:4.

24. Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG,

Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, … [85 authors] …, Manichaikul A, … [72 authors] …, Moffatt MF, Ober C, Nicolae DL. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 Jan;50(1):42-53.

Cited 38 times, IF= 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed genome-wide association analysis of asthma in the MESA study for this meta-analysis effort.

25. Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K,

Reedik M, Lahti J, Houston DK, Cornelis MC, van Rooij FJA, Dimitriou M, Kanoni S, Mikkilä V, Steffen LM, de Oliveira Otto MC, Qi L, Psaty B, Djousse L, Rotter JI, Harald K, Perola M, Rissanen H, Jula A, Krista F, Mihailov E, Feitosa MF, Ngwa JS, Xue L, Jacques PF, Perälä MM, Palotie A, Liu Y, Nalls NA, Ferrucci L, Hernandez D, Manichaikul A, Tsai MY, Kiefte-de Jong JC, Hofman A, Uitterlinden AG, Rallidis L, Ridker PM, Rose LM, Buring JE, Lehtimäki T, Kähönen M, Viikari J, Lemaitre R, Salomaa V, Knekt P, Metspalu A, Borecki IB, Cupples LA, Eriksson JG, Kritchevsky SB, Bandinelli S, Siscovick D, Franco OH, Deloukas P, Dedoussis G, Chasman DI, Raitakari O, Tanaka T. Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLOS ONE. 2017 Dec 13;12(12):e0186456.

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Cited 0 times, IF= 3.35, Rank 15 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul completed genome-wide association analysis of fish and EPA+DHA consumption in the MESA study for this meta-analysis effort.

26. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, … [106 authors] …,

Manichaikul A, … [105 authors] …; Charge Diabetes Working Group; EPIC-InterAct Consortium; EPIC-CVD Consortium; GOLD Consortium; VA Million Veteran Program, Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S. Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet. 2017 Dec;49(12):1758-1766.

Cited 72 times, IF= 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed rare variant analysis of lipid traits using ExomeChip data in the MESA study for this meta-analysis effort.

27. Manichaikul A, Nguyen JN. Genetic studies as a tool for identifying novel potential targets for

treatment of COPD. Eur Respir J. 2017 Nov 30;50(5).

Cited 0 times, IF= 8.49, Rank 5 of 59 Respiratory System Journals. 28. Raffield LM, Zakai NA, Duan Q, Laurie C, Smith JD, Irvin MR, Doyle MF, Naik RP, Song C,

Manichaikul AW, Liu Y, Durda P, Rotter JI, Jenny NS, Rich SS, Wilson JG, Johnson AD, Correa A, Li Y, Nickerson DA, Rice K, Lange EM, Cushman M, Lange LA, Reiner AP; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis TOPMed Working Group. D-Dimer in African Americans: Whole Genome Sequence Analysis and Relationship to Cardiovascular Disease Risk in the Jackson Heart Study. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2220-2227.

Cited 4 times, IF= 6.14, Rank 5 of 65 Peripheral Vascular Disease Journals. Dr. Manichaikul contributed expertise regarding study design and interpretation of MESA data for this effort.

29. Wang Z, Manichaikul A, Goff DC Jr, Mora S, Ordovas JM, Pajewski NM, Post WS, Rotter JI, Sale

MM, Santorico SA, Siscovick D, Tsai MY, Arnett DK, Rich S, Frazier-Wood AC. Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA). Hum Genet. 2017 Jun;136(6):715-726.

Cited 0 times, IF= 4.16, Rank 28 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed genetic association analysis of lipoprotein subfraction traits for selected single nucleotide polymorphisms (SNPs) and further provided guidance regarding interpretation and analysis of multi-ethnic data.

30. Zhu J, Manichaikul A, Hu Y, Chen YI, Liang S, Steffen LM, Rich SS, Tsai M, Siscovick DS,

Lemaitre RN, Li H, Lin X. Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians. Eur J Nutr. 2017 Jun;56(4):1477-1484.

Cited 3 times, IF= 4.13, Rank 14 of 83 Nutrition and Dietetics Journals. Dr. Manichaikul completed the genome-wide association analysis of saturated fatty acids in MESA.

31. Aschard H, Tobin MD, Hancock DB, Skurnik D, Sood A, James A, Vernon Smith A, Manichaikul

AW, Campbell A, Prins BP, Hayward C, Loth DW, Porteous DJ, Strachan DP, Zeggini E, O'Connor GT, Brusselle GG, Boezen HM, Schulz H, Deary IJ, Hall IP, Rudan I, Kaprio J, Wilson JF, Wilk JB, Huffman JE, Hua Zhao J, de Jong K, Lyytikäinen LP, Wain LV, Jarvelin MR, Kähönen

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M, Fornage M, Polasek O, Cassano PA, Barr RG, Rawal R, Harris SE, Gharib SA, Enroth S, Heckbert SR, Lehtimäki T, Gyllensten U; Understanding Society Scientific Group, Jackson VE, Gudnason V, Tang W, Dupuis J, Soler Artigas M, Joshi AD, London SJ, Kraft P. Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. Int J Epidemiol. 2017 Jun 1;46(3):894-904.

Cited 9 time, IF= 10.18, Rank 5 of 181 Public, Environmental and Occupational Health Journals. Dr. Manichaikul contributed expertise regarding study design and interpretation of MESA data for this effort.

32. Manichaikul A*, Wang XQ, Sun L, Dupuis J, Borczuk AC, Nguyen JN, Raghu G, Hoffman EA,

Onengut-Gumuscu S, Farber EA, Kaufman JD, Rabinowitz D, Stukovsky KDH, Kawut SM, Hunninghake GM, Washko GR, O'Connor GT, Rich SS, Barr RG, Lederer DJ. Genome-wide association study of subclinical interstitial lung disease in MESA. Respir Res. 2017 May 18;18(1):97. Cited 2 times, IF = 4.11, Rank 17 of 60 Respiratory System Journals.

33. Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski

J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, Perez J, Eicher JD, Kutalik Z, Xue L, Mahajan A, Renström F, Wu J, Qi Q, Ahmad S, Alfred T, Amin N, Bielak LF, Bonnefond A, Bragg J, Cadby G, Chittani M, Coggeshall S, Corre T, Direk N, Eriksson J, Fischer K, Gorski M, Neergaard Harder M, Horikoshi M, Huang T, Huffman JE, Jackson AU, Justesen JM, Kanoni S, Kinnunen L, Kleber ME, Komulainen P, Kumari M, Lim U, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, …, van Duijn CM, Heid IM, Mohlke KL, Marchini J, Loos RJF, Kilpeläinen TO, Liu CT, Borecki IB, North KE, Cupples LA. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017 Apr 26;8:14977. Cited 38 times, IF = 13.69, Rank 3 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul contributed expertise regarding study design and interpretation of MESA data for this effort.

34. Hu Y, Tanaka T, Zhu J, Guan W, Wu JHY, Psaty BM, McKnight B, King IB, Sun Q, Richard M, Manichaikul A, Frazier-Wood AC, Kabagambe EK, Hopkins PN, Ordovas JM, Ferrucci L, Bandinelli S, Arnett DK, Chen YI, Liang S, Siscovick DS, Tsai MY, Rich SS, Fornage M, Hu FB, Rimm EB, Jensen MK, Lemaitre RN, Mozaffarian D, Steffen LM, Morris AP, Li H, Lin X. Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations. J Lipid Res. 2017 May;58(5):974-981. Cited 2 times, IF = 4.88, Rank 59 of 293 Biochemistry and Molecular Biology Journals. Dr. Manichaikul contributed to design of this trans-ethnic fine mapping study and completed genome-wide association analysis of MUFAs in MESA White and Chinese for this meta-analysis effort.

35. Manichaikul A, Sun L, Borczuk AC, Onengut-Gumuscu S, Farber EA, Mathai SK, Zhang W, Raghu G, Kaufman JD, Hinckley-Stukovsky KD, Kawut SM, Jelic S, Liu W, Fingerlin TE, Schwartz DA, Sell JL, Rich SS, Barr RG, Lederer DJ. Plasma Soluble Receptor for Advanced Glycation End Products in Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2017 May;14(5):628-635. Cited 7 times, IF= 4.01, Rank 13 of 60 Respiratory System Journals.

36. Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J,

Okoli GN, Bowden J, … [176 authors] …, Manichaikul AW, Barr RG, Kahali B, Speliotes E,

10

Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol. 2017 May 1;3(5):636-651. Cited 84 times, IF = 20.88, Rank 8 of 223 Oncology Journals. Dr. Manichaikul provided genetic association for emphysema traits in MESA with selected telomere length-associated SNPs in this study.

37. Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson

VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH; COPDGene Investigators; ECLIPSE Investigators; LifeLines Investigators; SPIROMICS Research Group; International COPD Genetics Network Investigators; UK BiLEVE Investigators; International COPD Genetics Consortium. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017 Mar;49(3):426-432. Cited 66 times; IF = 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul contributed to development of the analysis plan for this study and supervised the staff biostatistician who completed genome-wide association analysis of COPD in the MESA study for this GWAS meta-analysis effort.

38. Pastore LM, Young SL, Manichaikul A, Baker VL, Wang XQ, Finkelstein JS. Distribution of the

FMR1 gene in females by race/ethnicity: women with diminished ovarian reserve versus women with normal fertility (SWAN study). Fertil Steril. 2017 Jan;107(1):205-211.e1. Cited 7 times; IF = 4.81, Rank 3 of 29 Reproductive Biology Journals. Dr. Manichaikul contributed to study design and supervised the staff biostatistician who completed the statistical analyses.

39. Zubair N, Graff M, Luis Ambite J, Bush WS, Kichaev G, Lu Y, Manichaikul A, Sheu WH, Absher

D, Assimes TL, Bielinski SJ, Bottinger EP, Buzkova P, Chuang LM, Chung RH, Cochran B, Dumitrescu L, Gottesman O, Haessler JW, Haiman C, Heiss G, Hsiung CA, Hung YJ, Hwu CM, Juang JJ, Le Marchand L, Lee IT, Lee WJ, Lin LA, Lin D, Lin SY, Mackey RH, Martin LW, Pasaniuc B, Peters U, Predazzi I, Quertermous T, Reiner AP, Robinson J, Rotter JI, Ryckman KK, Schreiner PJ, Stahl E, Tao R, Tsai MY, Waite LL, Wang TD, Buyske S, Ida Chen YD, Cheng I, Crawford DC, Loos RJF, Rich SS, Fornage M, North KE, Kooperberg C, Carty CL. Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci. Hum Mol Genet. 2016 Dec 15;25(24):5500-5512. Cited 7 times; IF = 5.57, Rank 31 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed genome-wide association analysis of lipid traits in the MESA study for this meta-analysis effort.

40. Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura

Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J,

11

Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, …, Liu Y, Rice KM, Desrivières S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377. Cited 47 times, IF = 10.36, Rank 5 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul completed genome-wide association analysis of alcohol consumption in the MESA study for this meta-analysis effort.

41. Grainger AT, Jones MB, Li J, Chen MH, Manichaikul A, Shi W. Genetic analysis of

atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice. Atherosclerosis. 2016 Nov;254:124-132. Cited 4 times, IF = 4.20, Rank 9 of 65 Peripheral Vascular Disease Journals. Dr. Manichaikul provided oversight for statistical analyses performed by the graduate student leading this manuscript.

42. Golden D, Kolmakova A, Sura S, Vella AT, Manichaikul A, Wang XQ, Bielinski SJ, Taylor KD,

Chen YI, Rich SS, Rodriguez A. Lymphocyte activation gene 3 and coronary artery disease. JCI Insight. 2016 Oct 20;1(17):e88628. Cited 6 times, IF= N/A, Rank not available yet. Dr. Manichaikul’s group performed all statistical analyses included in this manuscript.

43. Franceschini N, Carty CL, Lu Y, Tao R, Sung YJ, Manichaikul A, Haessler J, Fornage M,

Schwander K, Zubair N, Bien S, Hindorff LA, Guo X, Bielinski SJ, Ehret G, Kaufman JD, Rich SS, Carlson CS, Bottinger EP, North KE, Rao DC, Chakravarti A, Barrett PQ, Loos RJ, Buyske S, Kooperberg C. Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans. PLoS One. 2016 Oct 13;11(10):e0164132. Cited 6 times, IF = 3.35, Rank 15 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul performed replication analysis of selected SNPs for association with blood pressure traits in MESA.

44. Pastore LM, Manichaikul A, Wang XQ, Finkelstein JS. FMR1 CGG Repeats: Reference Levels

and Race-Ethnic Variation in Women With Normal Fertility (Study of Women's Health Across the Nation). Reprod Sci. 2016 Sep;23(9):1225-33.

Cited 4 times, IF = 2.51, Rank 15 of 29 Reproductive Biology Journals. Dr. Manichaikul supervised the statistical analysis of FMR1 CGG repeats in this study.

45. Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, Hill WD, Kacprowski T, Li J,

Lyytikäinen LP, Manichaikul A, …, Johnson AD, Edwards TL, Zakai NA, Lettre G, Reiner AP, Auer PL. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. Am J Hum Genet. 2016 Jul 7;99(1):22-39. Cited 12 times, IF = 10.09, Rank 12 of 171 Genetics and Heredity Journals. Dr. Manichaikul performed exome-wide analysis of white blood cell traits in the MESA study.

46. Eicher JD, Chami N, Kacprowski T, Nomura A, Chen MH, Yanek LR, Tajuddin SM, Schick UM,

Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, Manichaikul A, …, Kathiresan S, Faraday N, Auer PL, Reiner AP, Lettre G, Johnson AD. Platelet-Related Variants

12

Identified by Exomechip Meta-analysis in 157,293 Individuals. Am J Hum Genet. 2016 Jul 7;99(1):40-55. Cited 27 times, IF = 10.09, Rank 12 of 171 Genetics and Heredity Journals. Dr. Manichaikul performed exome-wide analysis of platelet traits in the MESA study.

47. Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L,

Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N, Yanek LR, Manichaikul A, …, Abumrad NA, Edwards TL, Ganesh SK, Auer PL, Johnson AD, Reiner AP, Lettre G. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016 Jul 7;99(1):8-21. Cited 21 times, IF = 10.09, Rank 12 of 171 Genetics and Heredity Journals. Dr. Manichaikul performed exome-wide analysis of red blood cell traits in the MESA study.

48. Manichaikul A, Rich SS, Allison MA, Guagliardo NA, Bayliss DA, Carey RM, Barrett PQ. KCNK3

Variants Are Associated With Hyperaldosteronism and Hypertension. Hypertension. 2016 Aug;68(2):356-64. Cited 8 times, IF = 6.74, Rank 3 of 65 Peripheral Vascular Disease Journals.

49. van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, … [88 authors] …, Gudnason V,

Rich SS, Psaty BM, Borecki IB, Boerwinkle E, Rotter JI, Cupples LA, van Duijn CM. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J Med Genet. 2016 Jul;53(7):441-9. Cited 12 times, IF = 5.74, Rank 19 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed genome-wide association analysis of lipid traits with imputation to the 1000 Genomes reference panel in MESA for this study.

50. Diep CS, Lemaitre RN, Chen TA, Baranowski T, Lutsey PL, Manichaikul AW, Rich SS, St-Jules

DE, Steffen BT, Tsai MY, Siscovick DS, Frazier-Wood AC. Acculturation and Plasma Fatty Acid Concentrations in Hispanic and Chinese-American Adults: The Multi-Ethnic Study of Atherosclerosis. PLOS One. 2016 Feb 12;11(2):e0149267. Cited 3 times, IF = 3.39, Rank 15 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul provided guidance regarding statistical analysis and interpretation of race/ethnic differences in MESA.

51. Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W,

Wang L, Biggs ML, Chen YD, Hernandez DG, Borecki I, Chasman DI, Rich SS, Ferrucci L, Irvin MR, Aslibekyan S, Zhi D, Tiwari HK, Claas SA, Sha J, Kabagambe EK, Lai CQ, Parnell LD, Lee YC, Amouyel P, Lambert JC, Psaty BM, King IB, Mozaffarian D, McKnight B, Bandinelli S, Tsai MY, Ridker PM, Ding J, Mstat KL, Liu Y, Sotoodehnia N, Barberger-Gateau P, Steffen LM, Siscovick DS, Absher D, Arnett DK, Ordovás JM, Lemaitre RN. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr. 2016 Feb;103(2):567-78. Cited 10 times, IF = 7.69, Rank 4 of 83 Nutrition and Dietetics Journals. Dr. Manichaikul completed SNP x environment interaction analysis of plasma lipid traits in MESA.

13

52. Vargas JD, Manichaikul A, Wang XQ, Rich SS, Rotter JI, Post WS, Polak JF, Budoff MJ, Bluemke DA. Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2016 Feb;245:230-6. Cited 18 times, IF = 4.20, Rank 9 of 65 Peripheral Vascular Disease Journals. Dr. Manichaikul’s group completed all genetic association analyses of subclinical atherosclerosis traits in MESA for this study.

53. Below JE, Parra EJ, Gamazon ER, Torres J, Krithika S, Candille S, Lu Y, Manichakul A, Peralta-

Romero J, Duan Q, Li Y, Morris AP, Gottesman O, Bottinger E, Wang XQ, Taylor KD, Ida Chen YD, Rotter JI, Rich SS, Loos RJ, Tang H, Cox NJ, Cruz M, Hanis CL, Valladares-Salgado A. Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. Sci Rep. 2016 Jan 19;6:19429. Cited 18 times, IF = 4.85, Rank 10 of 64 Multidisciplinary sciences Journals. Dr. Manichaikul’s group completed genetic association analysis of selected SNPs for lipid traits in MESA Hispanics.

54. Hu Y, Li H, Lu L, Manichaikul A, Zhu J, Chen YD, Sun L, Liang S, Siscovick DS, Steffen LM, Tsai

MY, Rich SS, Lemaitre RN, Lin X. Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations. Hum Mol Genet. 2016 Mar 15;25(6):1215-24. Cited 15 times, IF = 5.57, Rank 31 of 171 Genetics and Heredity Journals. Dr. Manichiakul completed GWAS analysis of n-3 and n-6 fatty acids in MESA White and Chinese for this GWAS meta-analysis effort.

55. Manichaikul A, Wang XQ, Zhao W, Wojczynski MK, Siebenthall K, Stamatoyannopoulos JA,

Saleheen D, Borecki IB, Reilly MP, Rich SS, Bornfeldt KE. Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis. J Lipid Res. 2016 Mar;57(3):433-42. Cited 4 times, IF = 4.88, Rank 59 of 293 Biochemistry and Molecular Biology Journals.

56. Ventetuolo CE, Mitra N, Wan F, Manichaikul A, Barr RG, Johnson C, Bluemke DA, Lima JA,

Tandri H, Ouyang P, Kawut SM. Oestradiol metabolism and androgen receptor genotypes are associated with right ventricular function. Eur Respir J. 2016 Feb;47(2):553-63. Cited 21 times, IF = 9.93, Rank 3 of 60 Respiratory System Journals. Dr. Manichaikul provided guidance regarding interpretation of genetic data for this study.

57. Wang Q, Grainger AT, Manichaikul A, Farber E, Onengut-Gumuscu S, Shi W. Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains. BMC Genet. 2015 Nov 10;16:133. Cited 5 times, IF = 2.71, Rank 93 of 171 Genetics and Heredity Journals. Dr. Manichaikul provided guidance for statistical analyses included in this manuscript.

58. van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S,

Manichaikul A, … [58 authors] …; CHARGE Lipids Working Group, Polasek O, Vitart V, Hayward C, Kolcic I, Wright AF, Rudan I, Joshi PK, Wilson JF, Lange LA, Wilson JG, Gudnason V, Harris TB, Morrison AC, Borecki IB, Rich SS, Padmanabhan S, Psaty BM, Rotter JI, Smith BH, Boerwinkle E, Cupples LA, van Duijn C. Fine mapping the CETP region reveals a common intronic

14

insertion associated to HDL-C. NPJ Aging Mech Dis. 2015 Nov 12;1:15011. Cited 2 times, IF= N/A, Rank not available yet. Dr. Manichaikul contributed genome-wide association analysis results for of HDL-C in MESA.

59. Gharib SA, Loth DW, Soler Artigas M, Birkland TP, Wilk JB, Wain LV, Brody JA, Obeidat M,

Hancock DB, Tang W, Rawal R, Boezen HM, Imboden M, Huffman JE, Lahousse L, Alves AC, Manichaikul A, Hui J, Morrison AC, Ramasamy A, Smith AV, Gudnason V, Surakka I, Vitart V, Evans DM, Strachan DP, Deary IJ, Hofman A, Gläser S, Wilson JF, North KE, Zhao JH, Heckbert SR, Jarvis DL, Probst-Hensch N, Schulz H, Barr RG, Jarvelin MR, O'Connor GT, Kähönen M, Cassano PA, Hysi PG, Dupuis J, Hayward C, Psaty BM, Hall IP, Parks WC, Tobin MD, London SJ; CHARGE Consortium; SpiroMeta Consortium. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015 Dec 1;24(23):6836-48. Cited 11 times, IF = 5.57, Rank 31 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed GWAS analysis of MESA data included in this consortium paper.

60. Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV,

Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkilä V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renström F, North KE, McKeown NM, Feitosa MF, Kanoni S, Smith CE, Garcia ME, Tiainen AM, Sonestedt E, Manichaikul A, … [32 authors] …, Dedoussis GV, Meigs JB, Siscovick DS. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Am J Clin Nutr. 2015 Nov;102(5):1266-78. Cited 20 times, IF = 7.69, Rank 4 of 83 Nutrition and Dietetics Journals. Dr. Manichaikul completed genetic risk score analysis for meat consumption in MESA.

61. Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T,

Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perälä MM, Qi Q, Sonestedt E, Manichaikul A, … [52 authors] …, Cupples LA, Loos RJ, Franks PW. Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015 Aug 15;24(16):4728-38. Cited 35 times, IF = 5.57, Rank 31 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed gene x diet score analysis for obesity traits in MESA.

62. Manichaikul A, Wang XQ, Musani S, Herrington D, Post WS, Wilson JG, Rich SS, Rodriguez A.

Association of the lipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease. PLOS One. 2015 May 20;10(5):e0125497. Cited 5 times, IF = 3.35, Rank 15 of 64 Multidisciplinary Sciences Journals.

63. Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT Jr, Seshadri S, Kooperberg C, Burger

KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, Hsu L, Jackson RD, Jarvik GP, Kim DS, Lakshminarayan K, Lange LA, Manichaikul A, Quinlan AR, Singleton AB, Thornton TA, Nickerson DA, Peters U, Rich SS; National Heart, Lung, and Blood Institute Exome Sequencing Project. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol. 2015 Jul;72(7):781-8. Cited 23 times, IF = 10.42, Rank 5 of 197 Clinical Neurology Journals. Dr. Manichaikul contributed to rare variant association analysis of ischemic stroke for this paper.

15

64. van Leeuwen EM, Karssen LC, Deelen J, Isaacs A, Medina-Gomez C, Mbarek H, Kanterakis A,

Trompet S, Postmus I, Verweij N, van Enckevort DJ, Huffman JE, White CC, Feitosa MF, Bartz TM, Manichaikul A, … [52 authors] …, de Bakker PI, Eline Slagboom P, Boomsma DI, Wijmenga C, van Duijn CM. Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels. Nat Commun. 2015 Mar 9;6:6065. Cited 17 times, IF = 13.69, Rank 3 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul completed genetic association analysis of lipid traits in MESA for this study.

65. Mozaffarian D, Kabagambe EK, Johnson CO, Lemaitre RN, Manichaikul A, Sun Q, Foy M, Wang

L, Wiener H, Irvin MR, Rich SS, Wu H, Jensen MK, Chasman DI, Chu AY, Fornage M, Steffen L, King IB, McKnight B, Psaty BM, Djoussé L, Chen IY, Wu JH, Siscovick DS, Ridker PM, Tsai MY, Rimm EB, Hu FB, Arnett DK. Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Am J Clin Nutr. 2015 Feb;101(2):398-406. Cited 20 times, IF = 7.69, Rank 4 of 83 Nutrition and Dietetics Journals. Dr. Manichaikul completed GWAS analysis of circulating trans-fatty acid levels in MESA.

66. Smith CE, Follis JL, Nettleton JA, Foy M, Wu JH, Ma Y, Tanaka T, Manichaikul AW, Wu H, Chu

AY, Steffen LM, Fornage M, Mozaffarian D, Kabagambe EK, Ferruci L, Chen YD, Rich SS, Djoussé L, Ridker PM, Tang W, McKnight B, Tsai MY, Bandinelli S, Rotter JI, Hu FB, Chasman DI, Psaty BM, Arnett DK, King IB, Sun Q, Wang L, Lumley T, Chiuve SE, Siscovick DS, Ordovás JM, Lemaitre RN. Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. Mol Nutr Food Res. 2015 Jul;59(7):1373-83. Cited 18 times, IF=4.52, Rank 7 of 130 Food Science and Technology Journals. Dr. Manichaiklu completed statistical analysis of SNP x dietary fatty acid effects on circulating fatty acids in the MESA study.

67. Chen W#, Brehm JM#, Manichaikul A#, Cho MH, Boutaoui N, Yan Q, Burkart KM, Enright PL,

Rotter JI, Petersen H, Leng S, Obeidat M, Bossé Y, Brandsma CA, Hao K, Rich SS, Powell R, Avila L, Soto-Quiros M, Silverman EK, Tesfaigzi Y, Barr RG, Celedón JC. A genome-wide association study of chronic obstructive pulmonary disease in Hispanics. Ann Am Thorac Soc. 2015 Mar;12(3):340-8. Cited 18 times, IF= 4.01, Rank 3 of 60 Respiratory System Journals. Dr. Manichaikul completed genome-wide analysis of COPD in MESA Hispanics for this study.

68. Lemaitre RN, King IB, Kabagambe EK, Wu JH, McKnight B, Manichaikul A, Guan W, Sun Q,

Chasman DI, Foy M, Wang L, Zhu J, Siscovick DS, Tsai MY, Arnett DK, Psaty BM, Djousse L, Chen YD, Tang W, Weng LC, Wu H, Jensen MK, Chu AY, Jacobs DR Jr, Rich SS, Mozaffarian D, Steffen L, Rimm EB, Hu FB, Ridker PM, Fornage M, Friedlander Y. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. J Lipid Res. 2015 Jan;56(1):176-8. Cited 15 times, IF = 4.88, Rank 59 of 293 Biochemistry and Molecular Biology Journals. Dr. Manichaikul completed genome-wide association analysis of very long-chain fatty acids in MESA for this study.

69. Coffee and Caffeine Genetics Consortium, Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A,

Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM,

16

Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, … [121 authors] …, van Duijn CM, Heiss G, Metspalu A, North KE, Ingelsson E, Nettleton JA, van Dam RM, Chasman DI. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry. 2015 May;20(5):647-656. Cited 60 times, IF = 12.44, Rank 7 of 142 Psychiatry Journals. Dr. Manichaikul completed GWAS analysis of coffee consumption in MESA for this consortium-based meta-analysis project.

70. Dijkstra AE, Boezen HM, van den Berge M, Vonk JM, Hiemstra PS, Barr RG, Burkart KM,

Manichaikul A, Pottinger TD, Silverman EK, Cho MH, Crapo JD, Beaty TH, Bakke P, Gulsvik A, Lomas DA, Bossé Y, Nickle DC, Paré PD, de Koning HJ, Lammers JW, Zanen P, Smolonska J, Wijmenga C, Brandsma CA, Groen HJ, Postma DS; LifeLines Cohort Study group. Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. Eur Respir J. 2015 Jan;45(1):60-75. Cited 6 times, IF = 9.93, Rank 3 of 60 Respiratory System Journals. Dr. Manichaikul completed genetic analysis of chronic mucus hypersecretion in MESA.

71. Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renström

F, Lin X, Angquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH, Holloway JW, Houston DK, Kanoni S, Kim YM, Laaksonen MA, Jääskeläinen T, Lee NR, Lehtimäki T, Lemaitre RN, Lu W, Luben RN, Manichaikul A, … [61 authors] …, Cupples LA, Rankinen T, Orho-Melander M, Wang T, Chasman DI, Franks PW, Sørensen TI, Hu FB, Loos RJ, Nettleton JA, Qi L. FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet. 2014 Dec 20;23(25):6961-72. Cited 51 times, IF = 5.69, Rank 23 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed SNP x dietary intake analysis for the outcome of body mass index in MESA.

72. Allen EK, Manichaikul A, Chen WM, Rich SS, Daly KA, Sale MM. Evaluation of replication of

variants associated with genetic risk of Otitis Media. PLOS One. 2014 Aug 4;9(8):e104212. Cited 2 times, IF = 3.39, Rank 15 of 64 Multidisciplinary Sciences journals. Dr. Manichaikul completed data cleaning and statistical analysis of genotyped SNPs for this project.

73. Smolonska J, Koppelman GH, Wijmenga C, Vonk JM, Zanen P, Bruinenberg M, Curjuric I,

Imboden M, Thun GA, Franke L, Probst-Hensch NM, Nürnberg P, Riemersma RA, van Schayck CP, Loth DW, Brusselle GG, Stricker BH, Hofman A, Uitterlinden AG, Lahousse L, London SJ, Loehr LR, Manichaikul A, Barr RG, Donohue KM, Rich SS, Pare P, Bossé Y, Hao K, van den Berge M, Groen HJ, Lammers JW, Mali W, Boezen HM, Postma DS. Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis. Eur Respir J. 2014 Oct;44(4):860-72. Cited 27 times, IF = 9.93, Rank 3 of 60 Respiratory System Journals. Dr. Manichiakul compelted genetic analysis of asthma and COPD traits for this study.

74. Street VA, Kujawa SG, Manichaikul A, Broman KW, Kallman JC, Shilling DJ, Iwata AJ, Robinson

LC, Robbins CA, Li J, Liberman MC, Tempel BL. Resistance to Noise-Induced Hearing Loss in 129S6 and MOLF Mice: Identification of Independent, Overlapping, and Interacting Chromosomal

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Regions. (2014) J Assoc Res Otolaryngol. 2014 Oct;15(5):721-38. Cited 3 times, IF = 2.96, Rank 8 of 42 Otorhinolaryngology Journals. Dr. Manichaikul completed quantitative trait locus (QTL) mapping of the mouse cross data for this study.

75. DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AV, Duan Q,

Oldmeadow C, Lee MK, Strachan DP, James AL, Huffman JE, Vitart V, Ramasamy A, Wareham NJ, Kaprio J, Wang XQ, Trochet H, Kähönen M, Flexeder C, Albrecht E, Lopez LM, de Jong K, Thyagarajan B, Alves AC, Enroth S, Omenaas E, Joshi PK, Fall T, Viñuela A, Launer LJ, Loehr LR, Fornage M, Li G, Wilk JB, Tang W, Manichaikul A, Lahousse L, … [115 authors] …, Dupuis J, Hall IP, Brusselle GG, Tobin MD, London SJ. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet. 2014 Jul;46(7):669-77. Cited 68 times, IF = 31.16, Rank 2 of 171 Genetics and Heredity Journals. Dr. Manichaikul’s group contributed GWAS analysis of forced vital capacity in MESA.

76. Guan W#, Steffen BT#, Lemaitre RN#, Wu JH#, Tanaka T#, Manichaikul A#, Foy M#, Rich SS,

Wang L, Nettleton JA, Tang W, Gu X, Bandinelli S, King IB, McKnight B, Psaty BM, Siscovick D, Djousse L, Ida Chen YD, Ferrucci L‡, Fornage M‡, Mozafarrian D‡, Tsai MY‡, Steffen LM‡*. Genome-wide association study of plasma n6 polyunsaturated Fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet. 2014 Jun;7(3):321-331. Cited 42 times, IF = 5.16, Rank 20 of 171 Genetics and Heredity Journals. Dr. Manichaikul completed GWAS analysis of circulating n-6 fatty acids in MESA for this study.

77. Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH,

Allison M, Budoff MJ, Clemens TL, Farber CR. Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest. 2014 Jun;124(6):2736-49. Cited 18 times, IF = 14.43, Rank 4 of 133 Medicine, Research and Experimental Journals. Dr. Manichaikul completed genetic association analysis of selected genetic variants for bone mineral density traits in MESA for this study.

78. Manichaikul A, Rich SS, Perry H, Yeboah J, Law M, Davis M, Parker M, Ragosta M, Connelly JJ,

McNamara CA, Taylor AM. A functionally significant polymorphism in ID3 is associated with human coronary pathology. PLOS One. 2014 Mar 6;9(3):e90222. Cited 10 times, IF = 3.39, Rank 15 of 64 Multidisciplinary Sciences Journals.

79. Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA,

Crosby JR, Fornage M, Isaacs A, Jakobsdottir J, Feitosa MF, Davies G, Huffman JE, Manichaikul A, … [83 authors] …, Wilson JG, van Duijn CM, Kooperberg C, Rich SS, Psaty BM, Rotter JI, O'Donnell CJ, Rice K, Boerwinkle E, Kathiresan S, Cupples LA. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014 Feb 6;94(2):223-32. Cited 158 times, IF = 10.36, Rank 8 of 167 Genetics and Heredity Journals. Dr. Manichaikul contributed exome-wide analysis of lipid traits in MESA for this consortium-based meta-analysis effort.

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80. Manichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, Budoff M, Austin JH, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJ, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O'Connor GT, Boezen HM, Rich SS‡, Barr RG‡*. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014 Feb 15;189(4):408-18. Cited 50 times, IF = 13.08, Rank 2 of 59 Respiratory System Journals.

81. Burkart KM, Manichaikul A, Wilk JB, Ahmed FS, Burke GL, Enright P, Hansel NN, Haynes D,

Heckbert SR, Hoffman EA, Kaufman JD, Kurai J, Loehr L, London SJ, Meng Y, O'Connor GT, Oelsner E, Petrini M, Pottinger TD, Powell CA, Redline S, Rotter JI, Smith LJ, Soler Artigas M, Tobin MD, Tsai MY, Watson K, White W, Young TR, Rich SS, Barr RG*. APOM and high-density lipoprotein cholesterol are associated with lung function and percent emphysema. Eur Respir J. 2014 Apr;43(4):1003-17. Cited 21 times, IF = 9.93, Rank 3 of 60 Respiratory System Journals. Dr. Manichaikul completed genetic association analysis of lung function and emphysema traits for selected SNPs in MESA.

82. Rowlan JS, Li Q, Manichaikul A, Wang Q, Matsumoto AH, Shi W. Atherosclerosis susceptibility

Loci identified in an extremely atherosclerosis-resistant mouse strain. J Am Heart Assoc. 2013 Aug 12;2(4):e000260. Cited 7 times, IF = 4.94, Rank 35 of 126 Cardiac and Cardiovascular Systems Journals. Dr. Manichaikul provided guidance for the statistical analyses included in this manuscript.

83. Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK,

Kanoni S, Lemaitre RN, Luan J, Mikkilä V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, … [ 40 authors] …, Dedoussis G, Cupples LA, Nettleton JA. (2013) Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013 Jun;97(6):1395-402. Cited 89 times, IF = 7.51, Rank 3 of 81 Nutrition and Dietetics Journals. Dr. Manichaikul completed the GWAS anlaysis of macronutrient intake in MESA for this consortium-based meta-analysis effort.

84. Powell R, Davidson D, Divers J, Manichaikul A, Carr JJ, Detrano R, Hoffman EA, Jiang R,

Kronmal RA, Liu K, Punjabi NM, Shahar E, Watson KE, Rotter JI, Taylor KD, Rich SS, Barr RG. (2013) Genetic ancestry and the relationship of cigarette smoking to lung function and percent emphysema in four race/ethnic groups: a cross-sectional study. Thorax. 2013 Jul;68(7):634-642. Cited 23 times, IF = 7.91, Rank 4 of 59 Respiratory System Journals. Dr. Manichaikul completed analysis of lung function and emphysema with respect to genetic ancestry for this study.

85. Liang S, Steffen LM, Steffen BT, Guan W, Weir NL, Rich SS, Manichaikul A, Vargas JD, Tsai MY.

type modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2013 May;228(1):181-7.

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Cited 19 times, IF = 4.09, Rank 10 of 63 Peripheral Vascular Disease Journals. Dr. Manichaikul provided guidance for ths analysis of genetic data in this study.

86. Wu JH, Lemaitre RN, Manichaikul A, Guan W, Tanaka T, Foy M, Kabagambe EK, Djousse L,

Siscovick D, Fretts AM, Johnson C, King IB, Psaty BM, McKnight B, Rich SS, Chen YD, Nettleton JA, Tang W, Bandinelli S, Jacobs DR Jr, Browning BL, Laurie CC, Gu X, Tsai MY, Steffen LM, Ferrucci L, Fornage M, Mozaffarian D. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Circ Cardiovasc Genet. 2013 Apr;6(2):171-83. Cited 36 times, IF = 4.79, Rank 26 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed GWAS analysis in MESA for fatty acids in the de novo lipogenesis pathway as part of this consortium-based meta-analysis effort.

87. Smith CE, Ngwa J, Tanaka T, Qi Q, Wojczynski MK, Lemaitre RN, Anderson JS, Manichaikul A,

Mikkilä V, van Rooij FJ, Ye Z, Bandinelli S, Frazier-Wood AC, Houston DK, Hu F, Langenberg C, McKeown NM, Mozaffarian D, North KE, Viikari J, Zillikens MC, Djoussé L, Hofman A, Kähönen M, Kabagambe EK, Loos RJ, Saylor GB, Forouhi NG, Liu Y, Mukamal KJ, Chen YD, Tsai MY, Uitterlinden AG, Raitakari O, van Duijn CM, Arnett DK, Borecki IB, Cupples LA, Ferrucci L, Kritchevsky SB, Lehtimäki T, Qi L, Rotter JI, Siscovick DS, Wareham NJ, Witteman JC, Ordovás JM*, Nettleton JA. Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. Int J Obes (Lond). 2013 Sep;37(9):1211-20. Cited 5 times, IF = 5.76, Rank 5 of 81 Nutrition and Dietetics Journals. Dr. Manichaikul completed genetic analysis of LRP1 variants with dietary fatty acids in MESA for this consortium-based effort.

88. Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF,

Kanoni S, Lehtimäki T, Lemaitre RN, Manichaikul A, … [45 authors] …, McKeown NM, Nettleton JA. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr. 2013 Mar;143(3):345-53. Cited 34 times, IF = 4.42, Rank 16 of 81 Nutrition and Dietetics Journals. Dr. Manichaikul completed SNP x magnesium intake analysis for fasting glucose and insulin traits in MESA as part of this consortium-based meta-analysis effort.

89. Frazier-Wood AC, Manichaikul A, Aslibekyan S, Borecki IB, Goff DC, Hopkins PN, Lai CQ,

Ordovas JM, Post WS, Rich SS, Sale MM, Siscovick D, Straka RJ, Tiwari HK, Tsai MY, Rotter JI, Arnett DK. Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity. Hum Genet. 2013 Apr;132(4):405-13. Cited 20 times, IF = 4.16, Rank 28 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed genetic association analysis of lipid particle size traits for selected SNPs in MESA.

90. Nettleton JA, Hivert MF, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK,

Hruby A, Djoussé L, Ngwa JS, Follis JL, Dimitriou M, Ganna A, Houston DK, Kanoni S, Mikkilä V, Manichaikul A, … [46 authors] …, Meigs JB, Franks PW. Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol. 2013 Jan

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15;177(2):103-15. Cited 45 times, IF = 5.60, Rank 14 of 176 Public, Environmental and Occupational Health Journals. Dr. Manichaikul completed analysis of healthy diet score x SNP effects on fasting glucose and insulin levels in MESA for this consoritum-based effort.

91. Richardson K, Nettleton JA, Rotllan N, Tanaka T, Smith CE, Lai CQ, Parnell LD, Lee YC, Lahti J,

Lemaitre RN, Manichaikul A, Keller M, Mikkilä V, Ngwa J, van Rooij FJ, Ballentyne CM, Borecki IB, Cupples LA, Garcia M, Hofman A, Ferrucci L, Mozaffarian D, Perälä MM, Raitakari O, Tracy RP, Arnett DK, Bandinelli S, Boerwinkle E, Eriksson JG, Franco OH, Kähönen M, Nalls M, Siscovick DS, Houston DK, Psaty BM, Viikari J, Witteman JC, Goodarzi MO, Lehtimäki T, Liu Y, Zillikens MC, Chen YD, Uitterlinden AG, Rotter JI, Fernandez-Hernando C, Ordovas JM. Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. Am J Hum Genet. 2013 Jan 10;92(1):5-14. Cited 44 times, IF = 10.36, Rank 8 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed analysis of lipid traits for the selected candidate SNP in MESA for this consortium-based effort.

92. Hancock DB#, Artigas MS#, Gharib SA#, Henry A#, Manichaikul A#, Ramasamy A#, Loth DW#,

… [ 73 authors] …, Gudnason V, Boezen HM, Barr RG, Cassano PA‡, Strachan DP‡, Fornage M‡, Hall IP‡, Dupuis J‡, Tobin MD‡*, London SJ‡*. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 2012;8(12):e1003098. Cited 75 times, IF = 7.06, Rank 16 or 167 Genetics and Heredity Journals. Dr. Manichaikul contributed genome-wide SNP x smoking analysis of pulmonary function in MESA and annotation of identified genetic loci for this effort.

93. Wilk JB#*, Shrine NR#, Loehr LR#, Zhao JH#, Manichaikul A#, Lopez LM#, Smith AV#, … [67

authors] …, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction. Am J Respir Crit Care Med. 2012 Oct 1;186(7):622-32. Cited 103 times, IF = 13.08, Rank 2 of 59 Respiratory System Journals. Dr. Manichaikul contributed GWAS results for analysis of airflow obstruction in MESA for this consortium-based meta-analysis effort.

94. Manichaikul A, Naj AC, Herrington D, Post W, Rich SS, Rodriguez A. Association of SCARB1

variants with subclinical atherosclerosis and incident cardiovascular disease: the Multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1991-9. Cited 20 times, IF = 6.23, Rank 4 of 63 Peripheral Vascular Disease Journals.

95. Manichaikul A*, Palmas W, Rodriguez CJ, Peralta CA, Divers J, Guo X, Chen WM, Wong Q,

Williams K, Kerr KF, Taylor KD, Tsai MY, Goodarzi MO, Sale MM, Diez-Roux AV, Rich SS, Rotter JI, Mychaleckyj JC. Population structure of Hispanics in the United States: the Multi-ethnic study of atherosclerosis. PLoS Genet. 2012;8(4):e1002640. Cited 45 times, IF = 7.06, Rank 16 of 167 Genetics and Heredity Journals.

96. Manichaikul A, Chen WM, Williams K, Wong Q, Sale MM, Pankow JS, Tsai MY, Rotter JI, Rich

SS, Mychaleckyj JC*. Analysis of family- and population-based samples in cohort genome-wide

21

association studies. Hum Genet. 2012 Feb;131(2):275-87. Cited 11 times, IF = 4.16, Rank 28 of 167 Genetics and Heredity Journals.

97. Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV,

Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, … [139 authors] …, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011 Sep 25;43(11):1082-90. Cited 157 times, IF = 31.69, Rank 2 of 167 Genetics and Heredity Journals. Dr. Manichaikul contributed replication analysis of selected SNPs for lung function traits in MESA for this consortium-based effort.

98. Chang RL, Ghamsari L, Manichaikul A, Hom EF, Balaji S, Fu W, Shen Y, Hao T, Palsson BØ,

Salehi-Ashtiani K, Papin JA. Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism. Mol Syst Biol. 2011 Aug 2;7:518. Cited 169 times, IF = 12.74, Rank 17 of 290 Biochemistry and Molecular Biology Journals. Dr. Manichaikul contributed to literature search and curation of the metabolic network reconstruction for this study.

99. Manichaikul A, Wang Q, Shi YL, Zhang Z, Leitinger N, Shi W. Characterization of Ath29, a major

mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression. Am J Physiol Heart Circ Physiol. 2011 Aug 2;7:518. Cited 11 times, IF = 3.57, Rank 22 of 63 Peripheral Vascular Disease Journals.

100. Lemaitre RN#, Tanaka T#, Tang W#, Manichaikul A#, Foy M#, Kabagambe EK, Nettleton JA,

King IB, Weng LC, Bhattacharya S, Bandinelli S, Bis JC, Rich SS, Jacobs DR Jr, Cherubini A, McKnight B, Liang S, Gu X, Rice K, Laurie CC, Lumley T, Browning BL, Psaty BM, Chen YD, Friedlander Y, Djousse L, Wu JH, Siscovick DS, Uitterlinden AG, Arnett DK, Ferrucci L, Fornage M, Tsai MY, Mozaffarian D, Steffen LM. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet. 2011 Jul;7(7):e1002193. Cited 161 times, IF = 7.06, Rank 16 of 167 Genetics and Heredity Journals. Dr. Manichaikul contributed GWAS analysis of n-3 fatty acids in MESA to this consortium-based meta-analysis effort.

101. Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM. Robust relationship

inference in genome-wide association studies. Bioinformatics. 2010 Nov 15;26(22):2867-73. Cited 402 times, IF = 8.04, Rank 2 of 57 Mathematical and Computational Biology Journals.

102. King KA, Choi BY, Zalewski C, Madeo AC, Manichaikul A, Pryor SP, Ferruggiaro A,

Eisenman D, Kim HJ, Niparko J, Thomsen J, Butman JA, Griffith AJ, Brewer CC. SLC26A4 genotype, but not cochlear radiologic structure, is correlated with hearing loss in ears with an enlarged vestibular aqueduct. Laryngoscope. 2010 Feb;120(2):384-9. Cited 31 times, IF = 2.54, Rank 7 of 42 Otorhinolaryngology Journals. Dr. Manichaikul provided guidance for statistical analyses included in this manuscript.

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103. Stadnisky MD, Manichaikul A, Lundgren AG, Brown MG. NK gene complex and chromosome 19 loci enhance MHC resistance to murine cytomegalovirus infection. Immunogenetics. 2009 Dec;61(11-12):755-64. Cited 4 times, IF = 2.24, Rank 105 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed QTL mapping of mouse cross data for this study.

104. Shavit JA, Manichaikul A, Lemmerhirt HL, Broman KW, Ginsburg D. Modifiers of von

Willebrand factor identified by natural variation in inbred strains of mice. Blood. 2009 Dec 17;114(26):5368-74. Cited 16 times, IF = 10.89, Rank 2 of 70 Hematology Journals. Dr. Manichaikul completed QTL mapping of mouse cross data for this study.

105. Chen WM, Manichaikul A, Rich SS. A generalized family-based association test for

dichotomous traits. Am J Hum Genet. 2009 Sep;85(3):364-76. Cited 33 times, IF = 10.36. Rank 8 of 167 Genetics and Heredity Journals. Dr. Manichaikul contributed to methodological development and writing of this manuscript.

106. Madeo AC, Manichaikul A, Reynolds JC, Sarlis NJ, Pryor SP, Shawker TH, Griffith AJ.

Evaluation of the thyroid in patients with hearing loss and enlarged vestibular aqueducts. Arch Otolaryngol Head Neck Surg. 2009 Sep;85(3):364-76. Cited 15 times, IF = 2.31, Rank 6 of 44 Otorhinolaryngology Journals. Dr. Manichaikul provided guidance for the statistical analyses included in this manuscript.

107. Manichaikul A#, Ghamsari L#, Hom EF#, Lin C#, Murray RR#, Chang RL#, Balaji S, Hao T,

Shen Y, Chavali AK, Thiele I, Yang X, Fan C, Mello E, Hill DE, Vidal M, Salehi-Ashtiani K, Papin JA. Metabolic network analysis integrated with transcript verification for sequenced genomes. Nat Methods. 2009 Aug;6(8):589-92. Cited 54 times, IF = 36.72, Rank 1 of 78 Biochemical Research Methods Journals.

108. Fushan AA, Simons CT, Slack JP, Manichaikul A, Drayna D. Allelic polymorphism within the

TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr Biol. 2009 Aug 11;19(15):1288-93. Cited 102 times, IF = 9.70, Rank 19 of 290 Biochemistry and Molecular Biology Journals. Dr. Manichaikul completed SNP association and haplotype analysis for human taste sensitivity traits as part of this study.

109. Manichaikul A*, Broman KW. Binary trait mapping in experimental crosses with selective

genotyping. Genetics. 2009 Jul;182(3):863-74. Cited 3 times, IF = 5.09, Rank 30 of 167 Genetics and Heredity Journals.

110. Madeo AC, Manichaikul A, Pryor SP, Griffith AJ. Do mutations of the Pendred syndrome

gene, SLC26A4, confer resistance to asthma and hypertension? J Med Genet. 2009 Jun;46(6):405-6. Cited 18 times, IF = 5.63, Rank 20 of 167 Genetics and Heredity Journals. Dr. Manichaikul provided guidance for the statistical analyses included in this manuscript.

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111. Manichaikul A, Moon JY, Sen S, Yandell BS, Broman KW*. A model selection approach for

the identification of quantitative trait loci in experimental crosses, allowing epistasis. Genetics. 2009 Mar;181(3):1077-86. Cited 93 times, IF = 5.09, Rank 30 of 167 Genetics and Heredity Journals.

112. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs

C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec;43(6):677-85. Cited 147 times, IF = 4.13, Rank 20 of 126 Cardiac and Cardiovascular Systems Journals. Dr. Manichaikul completed QTL mapping of mouse cross data for this study.

113. Manichaikul A, Palmer AA, Sen S, Broman KW. Significance thresholds for quantitative trait

locus mapping under selective genotyping. Genetics. 2007 Nov;177(3):1963-6. Cited 22 times, IF = 5.09, Rank 30 of 167 Genetics and Heredity Journals.

114. Broman KW, Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA. The X

chromosome in quantitative trait locus mapping. Genetics. 2006 Dec;174(4):2151-8. Cited 50 times, IF = 5.09, Rank 30 of 167 Genetics and Heredity Journals. Dr. Manichaikul completed simulations to establish the null distribution of the likelihood provide in QTL analysis of the X chromosome for experimental mouse crosses.

115. Manichaikul A, Dupuis J, Sen S, Broman KW*. Poor performance of bootstrap confidence

intervals for the location of a quantitative trait locus. Genetics. 2006 Sep;174(1):481-9. Cited 109 times, IF = 5.09, Rank 30 of 167 Genetics and Heredity Journals.

116. Drayna D, Manichaikul A, de Lange M, Snieder H, Spector T. Genetic correlates of musical

pitch recognition in humans. Science. 2001 Mar 9;291(5510):1969-72. Cited 176 times, IF = 38.06, Rank 2 of 64 Multidisciplinary Sciences Journals. Dr. Manichaikul developed and validated the pitch perception assessment test used to measure musical pitch recognition for this twin study.

Reviews and Technical Reports 1. Allen EK, Manichaikul A, Sale MM. Genetic contributors to otitis media: agnostic discovery

approaches. Curr Allergy Ashtma Rep. 2014;14:411. 2. Chen WM, Manichaikul A, Rich SS. Identifying variants that contribute to linkage for dichotomous

and quantitative traits in extended pedigrees. BMC Proc. 2011;5 Suppl 9: S68. 3. Manichaikul A, Moon JY, Sen S, Yandell BS, Broman KW A model selection approach for the

identification of quantitative trait loci in experimental crosses, allowing epistasis. 2008; Technical report #205, Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison.

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4. Manichaikul A, Johnson K, Man M Comparison of statistical methods for studying complex diseases in whole genome pharmacogenetic datasets, 2005 Proceedings of the American Statistical Association, Biopharmaceutical Section.

Short Communications 1. Grainger AT, Jones MB, Li J, Chen MH, Manichaikul A, Shi W. Data on genetic analysis of

atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice. Data Brief. 2016 Nov 19;9:1067-1069.

2. Vargas JD, Manichaikul A, Wang XQ, Rich SS, Rotter JI, Post WS, Polak JF, Budoff MJ,

Bluemke DA. Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis. Data Brief. 2016 Feb 15;7:229-42.

EDUCATIONAL ACTIVITIES Medical Student Summer Research Program, University of Virginia 2016 Amir Hashemi Rising 2nd Year Medical Student Doctoral Thesis Committee, University of Virginia 2013 – 2014 E. Kaity Allen Biochemistry and Molecular Genetics Doctoral Thesis Defense, University of Virginia 2014 E. Kaity Allen Biochemistry and Molecular Genetics SERVICE ACTIVITIES

A. University of Virginia School of Medicine

2018 Department of Public Health Sciences Faculty Search Committee for Assistant Professor in Epidemiology

2017 – pres. Data Steering and Monitoring Committee (DSMB) for Coleen McNamara R01 grant

B. Department 2019 – pres. Center for Public Health Genomics, Computing Club organizer 2016 – pres. Center for Public Health Genomics, Teaching Committee 2014 – 2018 Center for Public Health Genomics, Genome Sciences Seminar Committee

C. National 2017 – pres. Alpha-1 Foundation Grants Advisory Committee member 2017 – pres. Convenor, MESA TOPMed Multi-Omics Pulmonary Working Group 2016 – pres. Convenor, TOPMed Population Cohorts Pulmonary Working Group

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2014 – pres. Multi-Ethnic Study of Atherosclerosis (MESA): Genetics Presentations and Publications Committee

GRANT SUPPORT Ongoing Research Support R01 HL131565-04 (Manichaikul: PI) 05/15/16 – 04/30/21 $310,997 Annual Direct Costs Project Title: Genomic and Transcriptomic Analysis of Emphysema and Subclinical ILD Description: In this investigation, we will integrate genome-wide association studies of emphysema and ILD from MESA with transcriptomic data on lung and whole blood from GTEx to inform causal genes and pathways involved in pathogenesis of these important lung diseases. Role: Principal Investigator R01 HL130506-04 (Smith: PI) 07/01/16 – 06/30/21 $638,653 Annual Direct Costs Project Title: Chronic Obstructive Pulmonary Disease in Non-Smokers Description: The current application represents the first large-scale evaluation of COPD in non-smokers, and will use state-of-the-art techniques to test developmental and biological hypotheses to identify novel preventative and therapeutic strategies for this major subgroup of the US population. Role: Consortium PI R01 HL131862-03 (Rodriguez: PI) 09/01/16 – 05/31/20 $552,641 Annual Direct Costs Project Title: LAG-3 Deficiancy Linked to Proinflammation and Atherosclerosis Description: Our research work will examine the intersection of genetics, cholesterol, and inflammation in the causes of heart disease. The results of our work will provide customized approaches in the medical treatment of people with certain genetic cholesterol problems and heart disease. Role: Consortium PI R01 HG008965-04 (Chen: PI) 07/21/16 – 05/31/21 $250,000 Annual Direct Costs Project Title: Relationship inference in large genetic data Description: We propose to develop statistical methods and computationally efficient tools to infer cryptic family relationships, establish extended pedigrees/lineages, and increase power and resolution for mapping common and rare variants that contribute to human diseases. Role: Co-Investigator U01 HL120393-04 (Psaty/Rice/Rich: Multiple PIs) 04/01/14 – 03/31/20 $653,465 Annual Direct Costs Project Title: Rare variants and NHLBI traits in deeply phenotyped cohorts Description: In the proposed application from the original 5 CHARGE cohorts and 4 collaborating cohorts-all with jointly- called ExomeChip genotype data, the analysis of rare and uncommon variants will identify new genetic loci associated with a variety of heart, lung, and blood-related phenotypes. Role: Co-Investigator R01 AT008621-03 (Chilton: PI) 12/01/15 – 02/28/21 $636,509 Annual Direct Costs Project Title: Role of PUFA-Gene Interactions in Health Disparities

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Description: This project will test the hypothesis that the dramatic increase in omega-6 polyunsaturated fatty over the past 50 years, together with altered metabolism based on genetics and ancestral background of human populations, contributes to inflammatory diseases and plays a key role in health disparities observed between African and European Ancestry populations. Role: Co-Investigator P01 HL136275-02 (Hedrick: PI) 08/01/17 – 07/31/22 $1,927,831 Annual Direct Costs Project Title: Immune Cell Interactions in Atherosclerosis Core D: MESA Description: We will use innovative mass cytometry methods in monocytes from a large cohort of human subjects with elevated coronary artery calcium levels to identify novel cell subsets and profiles that confer cardiovascular risk. Role: Co-Investigator R01 CA211574-02 (Schildkraut: PI) 07/01/17 – 06/30/22 $573,262 Annual Direct Costs Project Title: Genomic and Transcriptomic Analysis of Breast and Ovarian Cancers Description: We will perform gene expression profiling of ovary tissue from tumor and non-tumor samples, and perform integrative analysis of genomic and transcriptomic data to inform genes and pathways underlying risk of ovarian cancer. Role: Co-Investigator R01 HL142028-01 (Lappalainen: PI) 05/01/18 – 04/30/20 $310,556 Annual Direct Costs Project Title: Integration of Omics Data to Improve Interpretation of Risk Variants in Lung Disease Description: In this project, we leverage of the unique strengths of the MESA cohort phenotype and multi-assay TOPMed genomic data to advance understanding of causal molecular processes and treatment discovery for chronic lower respiratory disease (CLRD), the third-leading cause of death. Role: Co-Investigator R01 AR071657-02 (Gerstenfeld/Farber: Multiple PIs) 04/01/18 – 02/28/23 $575,384 Annual Direct Costs Project Title: A Systems Genetics Approach to Identify BMD Genes Description: This project will define for the first time how genetic factors known to be related osteoporosis affect the expression of bone cell specific genes in humans and are related to changes in the ability of bone to support load. Role: Co-Investigator R03 HL141439-02 (Peloso: PI) 05/01/18 – 02/29/20 $54,760 Annual Direct Costs Project Title: Genetic determinants of triglyceride-rich lipoproteins to disentangle CHD risk Description: We will carry out data analysis using the Analytic Commons cloud computing environment, with a focus on the cardiopulmonary phenotypes available from multiple cohorts. Role: Co-Investigator R01 AI020565-34 (Platts-Mills: PI) 06/01/18 – 05/31/23 $365,164 Annual Direct Costs Project Title: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory disease Description: This study is designed to provide further understanding about the role of ticks bites to the sensitization that forms the basis of this novel form of food allergy. Role: Co-Investigator

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R01 HL105756-07 (Psaty: PI) 07/15/18 – 06/30/22 $12,500 Annual Direct Costs Project Title: CHARGE consortium: Gene discovery for CVD and aging phenotypes Description: We will be responsible for analysis of data for rare and common variants with innovative annotation of the genetic information with respect to specific phenotypic domains, principally pulmonary, lipid and cardiometabolic traits. Role: Co-Investigator Completed Research Support U01 HL117626-05 (Abecasis: PI) 01/01/17 – 4/30/18 Project Title: TOPMed Informatics Resource Center – Data work Group Support Description: This award provides support for whole genome sequence analysis of selected Heart, Lung and Blood traits of interest through the NHLBI’s TOPMed program. Role: Consortium PI ITN # 15-11-MH (Chen/Farber: PI) 03/31/15 – 03/30/18 Project Title: Data Analysis for TEDDY Study Description: We perform multi-omic analysis of genomic, transcriptomic, microbiome and metabolomic data to identify the determinants of Type 1 diabetes in children. Role: Co-Investigator R21 AI124490-02 (Erickson: PI) 03/15/16 – 02/28/18 Project Title: High-dimensional profiling of B cells in food allergy Description: The purpose of this project is to study how B cells produce IgE antibodies against allergens in food allergy. The information gained from the proposed research program will significantly contribute to our understanding of the molecular signals that control the development and lifespan of IgE- producing B cells. Role: Co-Investigator Alpha-1 Foundation Out of Cycle Research Grant (Manichaikul: PI) 02/01/15 – 01/31/18 Project Title: Alpha-1 Antitrypsin in African Americans and Hispanics Description: The aim of this proposal is to characterize, for the first time, the distribution of Alpha-1 Antitrypsin levels in African Americans and Hispanics. We further investigate the association of Alpha-1 Antitrypsin levels with inflammatory and endothelial activation markers, as well as measures of pulmonary disease in the general population. Role: Principal Investigator R01 HL089717-05A1 (Barrett/Bayliss: Multiple PIs) 09/01/13 – 11/30/17 Project Title: Two-pore domain potassium channels and aldosterone secretion Description: We use mouse models to understand the causes of low renin hypertension, and to inform studies in which we look for changes in human genes that could explain this type of hypertension. Role: Co-Investigator R01 DK097120-02 (Shi: PI) 07/05/13 – 05/31/17 Project Title: Genetic link between type 2 diabetes and atherosclerosis Description: The objective of this proposal is to search for genes and pathways that connect the two disorders. Findings from this work will lead to revelation of new targets for therapeutic intervention and development of new prevention strategies. Role: Co-Investigator R21 HL125574-02 (Hancock/Cassano: Multiple PIs) 12/01/14 – 11/30/16

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Project Title: Nutritional Genomics of Pulmonary Function Description: This study will explore whether two nutrients (omega-3 fatty acids and fiber) interact with genetic variants to influence lung function. The study is likely to identify new genetic variants associated with pulmonary function and also will further characterize previously established genetic associations with lung function. Role: Consortium PI R01 CA142081-06 (Schildkraut: PI) 06/01/15 – 05/31/16 Project Title: Epidemiology of Ovarian Cancer in African American Women Description: The purpose of this study is to enroll 1,000 ovarian cancer cases and 1,000 controls of African American ethnicity from 9 geographic regions in the U.S. to comprehensively evaluate known and suspected epidemiologic and genetic factors for ovarian cancer in this population. The collection of treatment and follow-up data will set the stage to address the disparity in ovarian cancer survival among African-American women diagnosed with ovarian cancer compared to whites. Role: Co-Investigator University of Virginia School of Medicine Transformative, Collaborative Pilot Grant (Erickson/McNamara/Woodfolk/Manichaikul: Multiple PIs) 01/01/15 – 12/31/15 Project Title: High-dimensional immune profiling of diverse inflammatory diseases by mass cytometry Description: In this project, we performed pilot studies using samples from studies of food allergy and atherosclerosis to establish pipelines for assay and statistical analysis using the new mass cytometry capabilities at the University of Virginia. Role: Multiple PI University of Virginia School of Medicine Transformative, Collaborative Pilot Grant (Shi: PI) 01/01/15 – 12/31/15 Project Title: Identification of RCN2 as a novel predictive biomarker of atherosclerotic arterial disease Description: Building on evidence from mouse studies indicating the role of Rcn2 in atherosclerosis, we perform a biomarker development pilot study by measuring circulating RCN2 levels in human samples. Role: Co-Investigator U01 NS069208-04 (Kittner: PI) 09/01/14 – 06/30/15 Project Title: Stroke Genetics Network (SIGN) Description: The long-range goal of our research is to characterize the genetic basis for stroke susceptibility in order to develop the effective prevention and treatment strategies that are desperately needed. Role: Co-Investigator on UVA Subaward R01 HL075656-09 (Rodriguez: PI) 07/05/10 – 05/31/15 Project Title: The Role of Scavenger Receptor Class B Type I in Humans Description: Our study will examine whether variations in the gene for the HDL receptor, scavenger receptor class B type I or SR-BI, might be associated with good levels of HDL and heart disease Role: Co-Investigator R01 HL103676-04 (Lederer: PI) 04/15/11 – 02/28/15 Project Title: Subclinical interstitial lung disease in MESA Description: Our goal is to understand the biological underpinnings of pulmonary fibrosis years before the first symptoms arise. The results of our study will be used to develop novel methods of preventing the development and progression of pulmonary fibrosis, a key step toward the prevention of chronic lung disease, a goal set by the NHLBI. Role: Co-Investigator

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Hearing Health Foundation Emerging Research Grant (Manichaikul: PI) 07/01/12 – 01/31/15 Project Title: Susceptibility to chronic otitis media: Translating gene to function Description: In this research, we perform targeted resequencing and analysis of genomic regions previously identified in genome-wide association studies of chronic and recurrent otitis media. Role: Principal Investigator R03 HG006893-02 (Chen: PI) 08/01/12 – 07/31/14 Project Title: Family-based rare variant association methods for quantitative traits Description: We propose to develop statistical methods and computational tools for the analysis of association between quantitative traits and rare genomic variants in families. Our proposed methods will facilitate the identification of genes contributing to variation in lipid levels, measures of subclinical atherosclerosis, and many other traits predictive of cardiovascular disease. Role: Co-Investigator R01 HD068440-03 (Pastore: PI) 09/15/11 – 06/30/14 Project Title: FMR1 CGG Repeats in Primary Ovarian Insufficiency Women (R01) Description: This study will compare this particular genetic disorder (Fragile X trinucleotide repeat level) in an existing infertile study group with two comparison groups: women who are infertile due to an anatomical cause unrelated to their ovaries, and a cohort of women with normal ovarian aging Role: Co-Investigator UC2 HL103010-02 (Rich: PI) 09/30/09 – 03/31/13 Project Title: Human Exome Sequencing in Six Well-Phenotyped NHLBI Cohorts Description: This research proposes to perform sequencing of coding regions across the human genome in order to identify or detect the potential causal changes that are associated with risk for cardiovascular, lung and blood diseases that may lead to better risk prediction, intervention and therapeutics (prevention). Role: Co-Investigator NIH Contract No. N01-HC-95159 (Kronmal: PI) 05/27/09 – 12/31/12 Project Title: Multi-Ethnic Study of Atherosclerosis SNP Health Association Resource Description: In this project, we provide analytic support for the Multi-Ethnic Study of Atherosclerosis (MESA) Genome-Wide Association genotyping resource including quality control, population structure analysis, and phenotypic analysis. Role: Co-Investigator RC1 HL100543-03 (Barr/Rich: Multiple PIs) 09/01/09 – 08/31/12 Project Title: Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes Description: This study proposes to measure emphysema on existing CT scans in a large multiethnic cohort and family study (n=8,120) with 1 million SNP genome-wide and linkage data to examine genetic risk for emphysema, which may lead to a better understanding of risk for emphysema. Role: Co-Investigator PRESENTATIONS Invited Presentations 2019 Retirement symposium for Dennis Drayna, National Institute on Deafness and Other

Communication Disorders, Bethesda, MD, Genetic and genomic analysis of complex traits in humans

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Biostatistics Seminar, Penn State University, Hershey, PA, Integrative multi-omic analysis for

GWAS follow-up studies: application to pulmonary function and emphysema Montgomery Blair High School, Senior Research Convention, Silver Spring, MD, Keynote

Speaker: From Blair to Genomics and Beyond 2018 NIH/NHLBI Workshop “Cardiopulmonary Function in Health and Disease: Leveraging NHLBI

Cohorts”, Bethesda, MD, Using Common Fund Resources and Publicly Available Data to Inform Genes Identified by GWAS of Pulmonary Function

MESA Steering Committee, Genetics Meeting, Rockville, MD, Update from the MESA TOPMed Multi-Omics Pulmonary Working Group

2017 Pulmonary Epidemiology Working Group, Columbia University, New York, NY, Genetics and

Genomics of Emphysema in the Multi-Ethnic Study of Atherosclerosis 2016 Center for Public Health Genomics, University of Virginia, Charlottesville, VA, Genetics and

Genomics of Emphysema in a Multi-Ethnic Population-Based Cohort Alpha-1 Foundation Investigators’ Meeting. Miami. Alpha-1 Antitrypsin in African Americans

and Hispanics: The Multi-Ethnic Study of Atherosclerosis Innovation Center for Biomedical Informatics, Georgetown University, Washington, DC,

Genetics and Genomics of Emphysema in a Multi-Ethnic Population-Based Cohort MESA Steering Committee, Lung Meeting, Bethesda, Alpha-1 Antitrypsin in African Americans

and Hispanics 2015 MESA Steering Committee, Genetics Meeting, Bethesda, Genetics of emphysema and

subclinical ILD in MESA Lung 2014 Cardiovascular Genomics Group, NHLBI/Framingham Heart Study, Framingham, SCARB1

and subclinical atherosclerosis / CVD in MESA with Stephen S. Rich and Annabelle Rodriguez 2012 Division of Biostatistics, Department of Public Health Sciences, University of Virginia,

Charlottesville, N-3 fatty acids and glucose/insulin related traits in the Multi-Ethnic Study of Atherosclerosis: a grant proposal MESA SHARe In-Person Meeting, Herndon, Genome-wide association analysis of emphysema in the Multi-Ethnic Study of Atherosclerosis

2011 NHLBI Exome Sequencing Project In-Person Meeting, Bethesda, Analysis of exome sequence data in Siblings with Ischemic Stroke

Division of Biostatistics, Department of Public Health Sciences, University of Virginia, Charlottesville, Exome sequencing in Siblings with Ischemic Stroke

MESA SHARe In-Person Meeting, Boston, Population structure of Hispanic Americans in the Multi-Ethnic Study of Atherosclerosis

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2010 Division of Biostatistics, Department of Public Health Sciences, University of Virginia, Charlottesville, Genome-wide association analysis in the Multi-Ethnic Study of Atherosclerosis, with application to lipid phenotypes

2009 Genomics:GTL Awardee Workshop VII and USDA-DOE Plant Feedstock Genomics for

Bioenergy Awardee Workshop, Bethesda, Maryland. Transcript verification coupled with metabolic network modelling for Chlamydomonas reinhardtii

2008 Department of Statistics, University of Virginia, Charlottesville, Mapping multiple QTL in

experimental crosses 2007 Department of Biomedical Engineering, University of Virginia, Charlottesville, Mapping multiple

QTL in experimental crosses Center for Public Health Genomics, University of Virginia, Charlottesville, Mapping multiple QTL in experimental crosses

Peer-Reviewed Abstracts Only those abstracts on which Dr. Manichaikul was the lead / presenting author are shown here. * denotes abstract oral presentation 1. *Trans-Omics for Precision Medicine Investigators Meeting. Tysons, VA, 2018. Whole

Genome Sequence Analysis of Pulmonary Function and COPD in >19,000 Multi-ethnic Participants of the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

2. *American Thoracic Society Conference 2018. San Diego, 2018. Genomic and transcriptomic

analysis of pulmonary function and emphysema on CT scan 3. American Thoracic Society Conference 2017. Washington, DC, 2017. Alpha-1 Antitrypsin in

African Americans and Hispanics: The Multi-Ethnic Study of Atherosclerosis

4. American Association for Cancer Research Annual Meeting 2017. Washington, DC, 2017. Identification of novel epithelial ovarian cancer loci in women of African ancestry from the Ovarian Cancer Association Consortium

5. The American Society of Human Genetics 66th annual meeting. Vancouver, 2016. Identification of novel epithelial ovarian cancer loci in women of African ancestry from the Ovarian Cancer Association Consortium

6. Cohorts for Heat and Aging Research in Genomic Epidemiology fall meeting. Charlottesville, 2016. Genomic and Transcriptomic Analysis of Emphysema and Subclinical ILD

7. 12th International Congress of Human Genetics meeting, Montreal, 2011. Population structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis

8. The American Society of Human Genetics 60th annual meeting, Washington, DC, 2010.

Analysis of family- and population-based samples in cohort genome-wide association studies 9. *Biomedical Engineering Society, St. Louis, 2008. Toward engineering of algal biohydrogen

production: a systems biology approach

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10. ENAR spring meeting, Arlington, 2008. Binary trait mapping in experimental crosses with selective genotyping*

11. Complex Trait Consortium, Braunschweig, 2007. Binary trait mapping in experimental crosses

with selective genotyping 12. Complex Trait Consotium, Chapel Hill, 2006. Identifying Quantitative Trait Loci and their

interactions by model selection 13. *ENAR spring meeting, Tampa, 2006. Poor Performance of bootstrap confidence intervals for

the location of a Quantitative Trait Locus 14. *Joint Statistical Meetings, Minneapolis, 2005. Don’t use the bootstrap for QTL mapping Invited Short Course 2007 Primary Lecturer for a six-week course on Biostatistical Modelling, Department of General

Practice and Primary Health Care, University of Helsinki, Finland