Curriculum Vitae Ali Emin Denktas, MD, FACC, FSCAI · 2020. 4. 17. · Fibrinolytic Acceleration of STEMI Treatment followed by urgent PCI (FAST-PCI) strategy on the mortality, re-infarction,

Curriculum Vitae Ali Emin Denktas, MD, FACC, FSCAI

I. GENERAL BIOGRAPHICAL INFORMATION A. Personal

1. Full Name: Ali Emin Denktas 2. Citizenship: USA and Turkish

B. Education

1. Undergraduate Education • Istanbul American Robert College • Graduated 1985 Dates attended: 1982-1985 • Istanbul, Turkey

2. Medical Education or Graduate Education • Istanbul University Cerrahpasa Faculty of Medicine • Degree: MD, Graduated 1991 at the top of my class. Dates attended: 1985-1991 • Istanbul, Turkey

3. Postgraduate Training • 10/1991 –7/1992 Istanbul University Istanbul Faculty of Medicine

Resident in Internal Medicine • 7/1992 –6/1994 Istanbul University Cerrahpasa Faculty of Medicine

Resident in Internal Medicine • 6/1994–6/1997 Mayo Clinic, Rochester, MN

Resident in Internal Medicine • 6/1997–7/2000 University of Texas-Houston HSC

Clinical Fellow in Cardiology • 7/1999–7/2000 University of Texas-Houston HSC

Chief Fellow • 8/2000–7/2002 Mayo Clinic, Rochester, MN

Interventional Cardiology Fellow • 7/2001–6/2002 Mayo Clinic, Rochester, MN

Chief Interventional Cardiology Fellow

C. Academic Appointments 1. Faculty Position(s) at BCM

Professor of Medicine 2019- Present Associate Professor of Medicine 2014-2019

2. Previous Faculty Position(s) at Other Institutions • September 2010 – January 12, 2014: Associate Professor of Medicine University of Texas Medical School at Houston • March 2005 – September 2010: Assistant Professor of Medicine University of Texas Medical School at Houston

3. Faculty Appointments at Other Institutions While at BCM • Clinical Associate Professor of Medicine University of Texas Medical School at Houston March 2014- Present

D. Other Advanced Training/Experience 1. Formal Sabbatical Leave None 2. Other Specialized Training Following Academic Appointment

Ali Emin Denktas, MD 2

E. Other Information 1. Honors or Awards

• Top 10% of the class of 1985 in American Robert College • Top student of the class in Istanbul University Cerrahpasa Faculty of Medicine, Fahrettin Kerim

Gokay Award for Academic Excellence. 1991, Istanbul, Turkey. • Leadership in Cardiology Research Award, University of Texas, 1999, Houston, Texas • 2005-2006 Dean’s Teaching Excellence Award, University of Texas at Houston • Houston Aortic Symposium Junior Investigator Research Grant Award, April 4-6, 2008 • 2008-2009 Dean’s Teaching Excellence Award, University of Texas at Houston • 2008-2009 Cardiology Fellow’s “Outstanding Faculty of the Year” Award • 2010-2011 Dean’s Teaching Excellence Award, University of Texas at Houston • 2012-2013 Dean’s Teaching Excellence Award, University of Texas at Houston • 2014 American College of Cardiology Emerging Faculty • 2016 Excellence in Interventional Cardiology Teaching Award Baylor College of Medicine • Top Doctor Houstonia Magazine 2014, 2015, 2016, 2017 • Star Award for Excellence in patient care Baylor College of Medicine 2018

2. Board Eligibility/Certification • American Board of Internal Medicine 1997 • Turkish Specialty Examination for Internal Medicine 1998 • American Board of Internal Medicine Cardiology Specialty Examination 2000, 2010 (Valid until

2020) • American Board of Internal Medicine Interventional Cardiology Board 2001, 2011 (Valid until

2021) • Turkish Specialty Examination for Cardiology 2002 3. Other Non-academic Positions

• Staff Cardiologist Acibadem Hospital System Istanbul Turkey, 10/2002 to 2/2005 • Director, Cardiac Catheterization Laboratory

Michael E. DeBakey VA Medical Center, January 13, 2014-Present

II. RESEARCH INFORMATION A. Research Support

1. Past: HSC-MS-10-0608 Denktas(PI) 11/30/2010-1/12/2014 Medtronic Endeavor Drug eluting stenting: Understanding Care, Antiplatelet agents and Thrombotic

Events: EDUCATE Overall goal: The purpose of this study is to collect additional safety information on the FDA approved

Endeavor stent. The study will also collect information about the effectiveness of anti-platelet therapy following a stent procedure.

Role: Principal Investigator HSC-MS-12-0538 Denktas(PI) 10/25/2012-1/12/2014 A Prospective Randomized Double Blinded Placebo Controlled Phase II Trial of Intra - Coronary

Infusion of AMR - 001, a Bone Marrow Derived Autologous CD34* Selected Cell Product, in Patients with Acute Myocardial Infarction.

Amorcyte PreSERVE AMI Study


Amorcyte LLC Overall goal: The primary objective of the study is to determine safety and the effect of intracoronary infusion of

AMR-001 (autologous bone marrow) on myocardial perfusion, measured by gated SPECT Myocardial Perfusion Imaging at baseline and six months, in subjects with ST Elevated Myocardial Infarction and stent placement.

Role: Principal Investigator HSC-MS-11-0055 Denktas(PI) 4/1/2011-1/12/2014 Percutaneous Septal Ablation with Septal Artery Coiling in Hypertrophic Obstructive Cardiomyopathy-

Retrospective registry study Overall goal: The objective of this study is to assess the outcomes of coiling of the septal perforator

artery in patients with hypertrophic obstructive cardiomyopathy. Role: Principal Investigator HSC-MS-09-0333 Denktas(PI) 7/12/2009-1/12/2014 A Multi-Center, Retrospective Registry Study designed to collect data from subjects that have been

treated using the IMPELLA 2.5 circulatory device per institution’s standard of care. The study will enroll all retrospective patients at selected institutions.

USPELLA Overall goal: The objective of this study is to investigate the characteristics and outcomes of patients

receiving Impella 2.5 system. Role: Principal Investigator HSC-MS-11-0231 Smalling(PI) 8/13/2011-1/12/2014 Placement of AoRTic TraNscathetER Valves Trial & The PARTNER II Trial with Nested Registries The PARTNER II Trial Overall goal: The purpose of this prospective randomized, multi-center, two arm trial is to determine the

safety and effectiveness of the SAPIEN XT transcatheter heart valve device (IDE# G090216) and NovaFlex delivery systems in inoperable patients with symptomatic critical aortic stenosis. Additionally, another device, the SAPIEN transcatheter heart valve device (IDE # G030069) will be used. Both devices were determined by the PI to be significant risk.

Role: Co-Investigator HSC-MS-11-0170 KL Gould(PI) 6/30/2011-1/12/2014 Study of coronary and myocardial perfusion using non-invasive, quantitative cardiac positron emission

tomography (PET), invasive angiography, and fractional flow reserve (FFR) PET/FFR Overall goal: The purpose of this prospective study is to determine the link between noninvasive and

invasive coronary physiology to develop cardiac positron emission tomography (PET) as the first-line test for identifying the subset of patients who will benefit from invasive procedures such as coronary angioplasty or bypass surgery.

Role: Co-Investigator HSC-MS-09-0264 Denktas (PI) 11/13/2009-1/31/2013 Osiris Therapeutics, Inc A Phase II, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety

and Efficacy of PROCHYMAL® (Ex Vivo Cultured Adult Human Mesenchymal Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction

Overall goal: The purpose of this study is to establish the safety and efficacy of PROCHYMAL® following a first acute myocardial infarction.

Role: Principal Investigator


HSC-MS-00-180-A Smalling (PI) 12/2002 – 2012 AGA Medical Corporation AMPLATZER PFO HDE Occluder Compassionate Use Study and Registry. Overall goal: The AMPLATZER® PFO Occluder is a percutaneous, transcatheter occlusion device

intended for the non-surgical closure of patent foramen ovale (PFO) in persons who have had a cryptogenic stroke due to presumed paradoxical embolism.. The AMPLATZER PFO Occluder has been developed as a potential alternative to the current standard of care. Current standard of care is medical treatment with either anticoagulation or antiplatelet agents. Standard of care medical treatment is used to prevent recurrent symptomatic cryptogenic strokes in subjects with PFO and presumed paradoxical emboli. This study enrolls patients whom are at high risk of a repeat stroke, that are not candidates for a protocol.

Role: Co-Investigator HSC-MS-02-186 Smalling (PI) 2/2003 – 2013 AGA Medical Corporation Protocol AGA-006: RESPECT TRIAL: Randomized Evaluation of Recurrent Stroke, TIA, or Peripheral

Embolism Comparing PFO Closure to Establish Current Standard of Care Treatment & Rev B dated (8/02)& Revision G (dated 6/03) & Revisions H (dated 5/2004).

Overall goal: The major of this study is to investigate whether percutaneous PFO closure is superior to current standard of care medical treatment in the prevention of recurrent embolic stroke or transient ischemic attacks.

Role: Co-Investigator HSC-MS-03-021 Smalling (PI) 9/2003 – 2011 University of Texas Houston Health Science Center, Centocor/Scios Pre-Hospital Administration of Thrombolytic Therapy with Urgent Care Artery Revascularization

(PATCAR) Pilot Trial. Overall goal: The major overall goal is to determine that the strategy of pre-hospital or rural (spoke)

hospital thrombolysis using partial dose thrombolytic therapy, followed by emergent transport to a level 1 Cardiovascular Center (Hub Hospital) for full dose glycoprotein 11b/111a receptor antagonist administration (Abciximab), and acute angioplasty and stenting of the culprit artery (Group B), will result in a combined endpoint of lower mortality and reduced re-infarction rate compared to pre-hospital standard thrombolytic therapy and usual care (Group A) at 30 days post intervention.

Role: Co-Investigator HSC-MS-05-0549 Denktas (PI) 1/30/2006 – 09/30/2008 Osiris Therapeutics, Inc A phase 1 randomized, double-blind, placebo-controlled, dose-escalation study to determine the safety

of intravenous ex-vivo cultured human mesenchymal stem cells (Provacelä) following acute myocardial infarction.

Overall goal: The major overall goal is to determine the safety and tolerability of 3 different doses of Provacel™ compared to placebo in subjects with acute myocardial infarction and to evaluate the effect of Provacel™ on exploratory efficacy endpoints.

Role: Principal Investigator HSC-MS-05-0549 Denktas (PI) 1/30/2006 – 09/30/2008 Osiris Therapeutics, Inc A Long-Term Follow-Up to evaluate the safety of adult human mesenchymal stem cells (Provacel) in

subjects following acute myocardial infarction.


Overall goal: The major overall goal is to establish the long-term safety of Provacel™ compared with placebo, in subjects following acute myocardial infarction.

Role: Principal Investigator HSC-MS-03-021 Denktas(PI) 9/2007 – 10/2008 PDL BioPharma, Inc. Reduced Dose Fibrinolytic Acceleration of STEMI Treatment Coupled with Urgent Percutaneous

Intervention Compared to Primary PCI: Results of the AMICO Registry AMICO: Alliance for Myocardial Infarction Care Optimization Overall goal: Rapid initiation of fibrinolytic therapy can shorten time to reperfusion, and mechanical

therapy of the culprit lesion is known to be beneficial. We evaluated the impact of reduced-dose Fibrinolytic Acceleration of STEMI Treatment followed by urgent PCI (FAST-PCI) strategy on the mortality, re-infarction, and stroke rates in STEMI patients, when compared with a primary PCI approach (PPCI).

Role: Principal Investigator HSC-MS-07-0272 Denktas (PI) 7/2008 – 2011 Houston Aortic Symposium Research Grant Circulating Vascular Stem Cells: A Predictor of Outcomes after Acute Myocardial Infarction Overall goal: The hypothesis to be tested in this research proposal is that the inability to launch a robust

circulating stem cell response to acute vascular events leading to myocardial ischemia or infarction or sudden cardiac death (SCD) may attenuate the post-infarct cardiac tissue repair, thus, resulting in a larger infarct and worse outcomes as well as poor neurologic status in the case of sudden cardiac death.

Role: Principal Investigator HSC-MS-09-0033 Smalling (PI) 2/28/2009 – 2011 Datascope, Corp and Duke Clinical Research Institute A Multi-center, Randomized, Controlled Study of Mechanical Left Ventricular Unloading with

Counterpulsation to Reduce Infarct Size Pre-PCI for Acute Myocardial Infarction—CRISP AMI Overall goal: To determine whether placing an Intra-aortic balloon pump (IABP) before mechanical

reperfusion decreases anterior myocardial infarct (MI) size and also to assess the effect of IABC before mechanical reperfusion on cardiovascular function and MACE.

Role: Co-Investigator

B. National Scientific Participation 1. Journal Editorial Boards, etc. • Marmara University Journal (Turkey) Editorial board • Anatolian Journal of Cardiology (Turkey) 2. Review Panels, etc. • Anatolian Journal of Cardiology (Turkey) Editorial Board, Reviewer • Texas Heart Institute Journal Reviewer • Mayo Clinic Proceedings Reviewer • Medical Sciences Reviewer • Atherosclerosis Thrombosis and Vascular Biology (ATVB) Reviewer • American Journal of Cardiology Reviewer • Journal of American College of Cardiology: Cardiovascular Interventions Reviewer • Archives of Medical Research Reviewer • Marmara University Journal (Turkey) Editorial board • Cardiology, Reviewer


• Circulation Interventions, Reviewer • Journal of American Heart Association, Reviewer • Journal of Catheterization and Cardiovascular Interventions, Reviewer 3. Professional Societies: • Fellow of American College of Cardiology (ACC) • Fellow of the Society of Cardiovascular Angiography and Interventions (SCAI) • ACC Exhibits Committee member 2015-Present • ACC Anticoagulation workgroup member 2015-2018 • ACC Competency Management Committee member 2018-Present • SCAI Education Committee member 2018-Present

4. Elected Positions, etc. 5. Invited Lectures, Presentations, Seminars a. International

1. Difficult Patients Difficult Lesions Panelist 4th Congress of Update in Cardiology and Cardiovascular Surgery, Antalya, Turkey, December 1, 2008

2. Denktas, AE. Fibrinolytic Therapy at the Pre-hospital Phase and Emergency Department. 4th Congress of Update in Cardiology and Cardiovascular Surgery, Antalya, Turkey, December 1, 2008.

3. Denktas, AE. Percutaneous Treatment Options in Patients with Low EF. 4th Congress of Update in Cardiology and Cardiovascular Surgery, Antalya, Turkey, December 1, 2008.

4. Denktas, AE. Five questions Five Answers in Septal ablation in Hypertrophic Cardiomyopathy. 4th Congress of Update in Cardiology and Cardiovascular Surgery, Antalya, Turkey, December 1, 2008. 5. Denktas, AE. Presentation: Optimal Treatment of STEMI. 22nd Annual Interventional Meeting with Live Cases, Istanbul Turkey, April 26, 2015. 6. Denktas, AE Live case operator: Bifurcation Case 22nd Annual Interventional Meeting with Live Cases, Istanbul, Turkey, April 25, 2015 7. Denktas, AE Presentation: PCI Complications How to Avoid, 6th EAZI (Egypt A-Z Intervention)/ 3rd ENTERVIN (Egypt iNTERVentIoN) Course 2015 on fundamentals and advanced intervention of today and tomorrow, Cairo Egypt, October 28, 2015 8. Denktas AE Presentation: Different Techniques for Different Lesions, 6th EAZI (Egypt A-Z Intervention)/ 3rd ENTERVIN (Egypt iNTERVentIoN) Course 2015 on fundamentals and advanced intervention of today and tomorrow, Cairo Egypt, October 29, 2015 9. Denktas, AE Panelist Radial Summit 6th EAZI (Egypt A-Z Intervention)/ 3rd ENTERVIN (Egypt iNTERVentIoN) Course 2015 on fundamentals and advanced intervention of today and tomorrow, Cairo Egypt, October 29, 2015


10. Denktas, AE Case Presenter and Discussant Worst Case Best Save 6th EAZI (Egypt A-Z Intervention)/ 3rd ENTERVIN (Egypt iNTERVentIoN) Course 2015 on fundamentals and advanced intervention of today and tomorrow, Cairo Egypt, October 29, 2015 11. Denktas, AE Presentation: What to Look for Before, During and Immediately after TAVI CT/Echo, World Echo Conference, Istanbul Turkey, November 21, 2016 12. Denktas, AE Presentation: Is the Discussion Over for Thrombus Aspiration? 22nd Annual Interventional Meeting with Live Cases, Istanbul, Turkey, April 23, 2016 13. Denktas, AE, PCI complications, How to Avoid, Cardio Egypt EAZI (Egypt A-Z Intervention), Cairo, Egypt, February 26, 2018 14. Denktas, AE, High Risk PCI in Relation to Cardiogenic Shock, Cardio Egypt EAZI (Egypt A-Z Intervention), Cairo, Egypt, February 28, 2018 15. Denktas, AE, Chairperson, Treatment Strategies in STEMI Patients with Cardiogenic Shock, Cardio Egypt EAZI (Egypt A-Z Intervention), Cairo, Egypt, February 28, 2018 16. Denktas, AE, MI Mechanical Complication, Case Based, Cardio Egypt EAZI (Egypt A-Z Intervention), Cairo, Egypt, February 28, 2018 17. Denktas, AE, State of the art Lecture: Joint with ACCA, Interventional Cardiologists Journey, Cardio Egypt EAZI (Egypt A-Z Intervention), Cairo, Egypt, February 28, 2018

b. National 1. American College of Cardiology Atlanta Georgia,: Session chair : Inflammation and coronary artery disease, March 2002

2. Denktas, AE. New Treatments in Acute Myocardial Infarction. Fiesta 2006 Symposium, San Antonio, TX, September 7, 2006.

3. Denktas, AE, SCAI Scientific sessions Chicago: Moderator March 29, 2008-April 1, 2008

4. Denktas, AE. The Multicenter GLASTO Registry: Improved Outcomes With Facilitation Before Angioplasty (Reduced Dose Fibrinolytic Acceleration of STEMI Treatment Coupled with Urgent Percutaneous Intervention Compared to Primary PCI: Results of the AMICO Registry AMICO: Alliance for Myocardial Infarction Care Optimization) Interventional Strategies and Adjunct Pharmacology in ACS and AMI STEMI Session II: Special Session: Facilitation, Rescue, Transfer Issues. Transcatheter Cardiovascular Therapeutics Annual Conference, Washington, DC, Oct 21, 2007.

5. Denktas, AE. Panelist: Interventional Strategies and Adjunct Pharmacology in ACS and AMI STEMI Session II: Special Session: Facilitation, Rescue, Transfer Issues. Transcatheter Cardiovascular Therapeutics Annual Conference, Washington, DC, Oct 21, 2007.

6. Denktas AE. Panelist: Cardiovascular Conference Focus on the Middle East - Panel Discussion on Coronary artery disease. American College of Cardiology Annual Conference, Atlanta, GA, March 13, 2010


7. Denktas AE. Operator: i2 Live Cases: 2204. Live Case Session 4: Endovascular, Hermann Hospital. American College of Cardiology Annual Conference, Atlanta, GA (live case in Houston, TX), March 15, 2010

8. Denktas AE. Presentation: Septal Ablation by Coil Embolization for Hypertrophic Cardiomyopathy. Transcatheter Cardiovascular Therapeutics Annual Conference, Washington, DC, September 22, 2010.

9. Denktas AE. Presentation: Stem Cells as Markers after Myocardial Infarction. Texans for Stem Cell Research, Austin, TX, October 27, 2010. YouTube: http://www.youtube.com/watch?v=WSkHmykg2sI & http://www.youtube.com/watch?v=Vj0cAcrbddc

10. Denktas AE. Presentation: Strategies for Cardiovascular Repair: Stem Cells and Beyond. Transcatheter Cardiovascular Therapeutics Annual Conference, San Francisco, CA, November 7, 2011.

11. Denktas AE. Panelist: Alcohol Septal Ablation. Transcatheter Cardiovascular Therapeutics Annual Conference, San Francisco, CA, November 10, 2011.

12. Denktas AE. Presentation: Alcohol Septal Ablation, Procedural Complication(s) – Case Presentation. Transcatheter Cardiovascular Therapeutics Annual Conference, San Francisco, CA, November 10, 2011.

13. Denktas AE. Presentation: Does Total Ischemic Time Determine the Response to Cardiac Stem Cell Therapy in Patients with STEMI?. Texans for Stem Cell Research, Austin, TX, October 19, 2012.

14. Denktas, AE. Presentation: Total Ischemic Time: The Correct Focus of Attention. 2nd Annual Cardiology Symposium, Redding, CA, October 5, 2013.

15. Denktas, AE Presentation: Evolution in Management of High-Risk PCI, Adjunctive Mechanical Circulatory Support, Hemodynamic support Case, C3 Conference, Orlando, FL, June 14, 2015

16. Denktas, AE Presentation: Cath Lab Disasters Case Presentation, C3 Conference, Orlando, FL, June 15, 2015

17. Denktas, AE Presentation Vein Graft Interventions, American Heart Association Scientific Sessions, Orlando, FL. November 10, 2015

18. Denktas, AE Presentation: Unprotected Left Main Disease Cardiovascular Research Technologies (CRT), Washington, DC, February 20, 2016

19. Denktas, AE Presentation: Challenging Septal Ablation Case Emory Practical Intervention Course – Southeastern Consortium March 4, 2016

20. Denktas, AE Presentation: Tips and Tricks for Calcified Lesions, American College of Cardiology Scientific Sessions, Chicago, IL, April 3, 2016

21. Denktas, AE, Maintenance of Certification Module Faculty, American College of Cardiology Scientific Sessions, Chicago, IL, April4, 2016


22. Denktas, AE Moderator: International Joint Session with Korean Complex Cardiovascular

Intervention (CCI) Group: Complex Coronary Intervention Session Complex Cardiovascular Therapeutics Conference, Orlando, FL, June 29, 2016.

23. Denktas, AE Presentation: Complication Management in Complex PCI: Perforations, Dissections,

Abrupt Closure, American Heart Association Scientific Sessions, New Orleans, LA, November 13, 2016

24. Denktas, AE, Panelist: TAVR Simulation, American Heart Association Scientific Sessions, New

Orleans, LA, November 13, 2016 25. Denktas, AE, Presentation: TAVR with Tandem Support Interesting Structural Case, Cardiovascular

Research Therapeutics, Washington, DC, February 21, 2017 26. Denktas, AE, Presentation: Acute Vessel Closure: Typical Causes and Their Prevention and

Treatment Strategies, Complex Cardiovascular Catheter Therapeutics, Orlando, FL, June 27, 2017 27. Denktas, AE, Presentation: How to Build your Interventional Practice: The Sky is the Limit,

Complex Cardiovascular Catheter Therapeutics, Orlando, FL, June 30, 2017 28. Denktas, AE, Moderator: Complex PCI with Hemodynamic Support

Complex Cardiovascular Catheter Therapeutics, Orlando FL, June 30, 2017 29. Denktas, AE, Moderator: Simulation Session: Coronary Angiography Skills, American Heart

Association Scientific Sessions, Anaheim, CA, November 12, 2017 30. Denktas, AE, Moderator: Simulation Session: Valvular Heart Disease: TAVR, American Heart

Association Scientific Sessions, Anaheim, CA, November 12, 2017 31. Denktas, AE, Panel Participant, Help me Manage my Worst Complications, American Heart

Association Scientific Sessions, Anaheim, CA, November 13, 2017 32. Denktas, AE, VA Coronary Interesting Cases, Session Moderator, Cardiovascular Research

Technologies (CRT), Washington, DC, March 5, 2018 33. Denktas, AE, VA Coronary Interesting Cases, Coronary Case Roundtable, Panel Moderator,

Cardiovascular Research Technologies (CRT), Washington, DC, March 5, 2018 34. Denktas, AE, VA Structural Interesting Cases, Speaker, Challenging HOCM Case, Cardiovascular

Research Technologies (CRT), Washington, DC, March 5, 2018 35. Denktas, AE, VA Structural Interesting Cases, Panelist, Cardiovascular Research Technologies

(CRT), Washington, DC, March 5, 2018 36. Denktas, AE, Coronary Interventions at the VA and the Management of End Stage Complex

Coronary Disease, Panelist, Cardiovascular Research Technologies (CRT), Washington, DC, March 5, 2018

37. Denktas, AE, Panelist: Case presentations, Emory Practical Intervention Course – Southeastern

Consortium April 20, 2018


38. Denktas, AE, Presentation: Acute Vessel Closure: Typical Causes and Their Prevention and

Treatment Strategies, Complex Cardiovascular Catheter Therapeutics, Orlando FL, June 17, 2018 39. Denktas, AE, Presentation: Mechanical Circulatory Support in Catheterization Laboratory: How Do

I Choose?, Complex Cardiovascular Catheter Therapeutics, Orlando FL, June 17, 2018 40. Denktas, AE, Presentation: Structural Heart Disease in My VA: My Best 3 Cases this Year,

Complex Cardiovascular Catheter Therapeutics, Orlando FL, June 19, 2018

41. Denktas, AE, Moderator, TAVR in 2018, American Heart Association Scientific Sessions, Chicago, IL, November 10, 2018

42. Denktas, AE, Presenter, Emotionally-rich Moments: Complications in the Cath Lab, when things go

wrong. American Heart Association Scientific Sessions, Chicago, IL, November 11, 2018 43. Denktas, AE, Moderator, TAVR Simulation, American Heart Association Scientific Sessions,

Chicago, IL, November 11, 2018 44. Denktas, AE, Presentation: Complex PCI Case in Patients with Cardiogenic Shock, Cardiovascular

Research Technologies (CRT), Washington, DC, March 4, 2019 45. Denktas, AE, Panel Moderator, Interventions at the VA: Protected PCI Session II, Cardiovascular

Research Technologies (CRT), Washington, DC, March 4, 2019 46. Denktas, AE, Panelist, Coronary Interventions at the VA, Cardiovascular Research Technologies

(CRT), Washington, DC, March 5, 2019

c. Regional

Please see section III D f for local and regional presentations.

C. Publications 1. Full Papers in Peer Review Journals a. Published 1. Denktas AE and Elkin PL. 75-year-old man with fever, weight loss, and diarrhea. Mayo Clinic

proceedings. 1998;73:983-6. 2. Basaria S, Denktas AE, Ghani M and Thandroyen F. Ventricular septal defect patch causing right

ventricular inflow tract obstruction. Circulation. 1999;100:e12-3

3. Cafri C, Denktas AE, Crystal E, Ilia R and Battler A. Contribution of stenting to the results of rescue PTCA. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 1999;47:411-4.

4. Schmermund A, Denktas AE, Rumberger JA, Christian TF, Sheedy PF, 2nd, Bailey KR and

Schwartz RS. Independent and incremental value of coronary artery calcium for predicting the extent of angiographic coronary artery disease: comparison with cardiac risk factors and radionuclide perfusion imaging. Journal of the American College of Cardiology. 1999;34:777-86.


5. Denktas AE and Smalling RW. Pasta without sauce? Catheterization and cardiovascular

interventions : official journal of the Society for Cardiac Angiography & Interventions. 1999;48:269-70

6. Cafri C, Denktas AE, Koval S, Ilia R and Battler A. Images in Cardiovascular Interventions: Triple

complication of AVE Microstent: splitting, migration and restenosis. International journal of cardiovascular interventions. 2000;3:51.

7. Assali AR, Sdringola S, Ghani M, Denktas AE, Yepes A, Hanna GP, Schroth G, Fujise K,

Anderson HV, Smalling RW and Rosales OR. Intracoronary adenosine administered during percutaneous intervention in acute myocardial infarction and reduction in the incidence of "no reflow" phenomenon. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2000;51:27-31; discussion 32

8. Denktas AE, Bayes-Genis A, Schwartz RS. New approaches to the pharmacological treatment of

angina. Curr Opin Phramacol. Apr 2001;1(2):151-8. 9. Assali AR, Sdringola S, Moustapha A, Rihner M, Denktas AE, Lefkowitz MA, Campbell M and

Smalling RW. Endovascular repair of traumatic pseudoaneurysm by uncovered self-expandable stenting with or without transstent coiling of the aneurysm cavity. Catheterization and cardiovascular interventions: official journal of the Society for Cardiac Angiography & Interventions. 2001;53:253-8.

10. Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, Sheedy II PF, Peyser

PA, Schwartz RS. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation, 2001;104(4):412-7.

11. Orford JL, Fasseas P, Denktas AE, Bybee KA, Rihal CS, Holmes DR Jr. Refractory angina and

anterior ischemia in a patient with a patent left internal mammary artery bypass graft. J Invasive Cardiol., 2001;13(11):763-6.

12. Denktas AE, Holmes DR Jr, Schwartz RS. Angio-Seal in overweight patients: is Angio-Seal use

safe in overweight patients or is it unsafe in lower-weight patients? J Invasive Cardiol, Sep 2001;3(9):626-7.

13. Fasseas P, Orford JL, Denktas AE, Berger PB. Distal protection devices during percutaneous

coronary and carotid interventions. Curr Control Trials Cardiovasc Med, Dec 2001;2(6):286-291. 14. Keelan PC, Ashai K, Rumberger JA, Denktas AE, Sheedy PF, Bielak F, Jamjoum LS, Peyser PP,

Schwartz RS. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography - Response. Circulation, Apr 30, 2002105(17):E127.

15. Orford JK, Fasseas P, Denktas AE, Garratt KN. Anterior ischema secondary to embolization of the

posterior descending artery in a patient with a chronic total occlusion of the left anterior descending artery. J Invasive Cardiol, Sept 2002;14(9):527-30.

16. Orford JL, Fasseas P, Denktas AE, Hammes L, Garratt KN, Berger PB, Holmes DR Jr, Barsness

GW. Safety and efficacy of cutting balloon angioplasty: the Mayo Clinic experience. J Invasive Cardiol, Dec 2002;14(12):720-4.


17. Barcin C, Denktas AE, Garratt KN, Higano ST, Holmes DR Jr, Lerman A. Relation of

Thrombolysis in myocardial infarction (TIMI) frame count tocoronary flow parameters. Am J Cardiol, 2003;91(4):466-9.

18. Ghani MK, Boccalandro F, Denktas AE, Barasch E. Right atrial thrombus formation associated

with central venous catheters utilization in hemodialysis patients. Intensive Care Med, 2003;29(10):1829-32,

19. Fasseas P, Orford JL, Panetta CJ, Bell MR, Denktas AE, Lennon RJ, Holmes DR Jr, Berger PB.

Incidence, correlates, management, and clinical outcome of coronary perforation: analysis of 16,298 procedures. Am Heart J, Jan 2004;147(1):140-5.

20. Barcin C, Denktas AE, Lennon RJ, Hammes L, Higano ST, Holmes DR Jr, Garratt KN, Lerman A.

Comparison of combination therapy of adenosine and nitroprusside with adenosine alone in the treatment of angiographic no-reflow phenomenon. Catheter Cardiovasc Interv, 2004;61(4):484-91.

21. Orford JL, Denktas AE, Williams BA, Fasseas P, Willerson JT, Berger PB, Holmes DR Jr;

PRESTO Investigators. Routine intravascular ultrasound scanning guidance of coronary stenting is not associated with improved clinical outcomes. Am Heart J., 2004;148(3):501-6.

22. Fasseas P, Orford JL, Lennon R, O'Neill J, Denktas AE, Panetta CJ, Berger PB, Holmes DR Jr.

Cutting balloon angioplasty vs. conventional balloon angioplasty in patients receiving intracoronary brachytherapy for the treatment of in-stent restenosis. Catheter Cardiovasc Interv, 2004;63(2):152-7.

23. Elesber AA, Conover CA, Denktas AE, Lennon RJ, Holmes DR Jr, Overgaard MT, Christiansen

M, Oxvig C, Lerman LO, Lerman A. Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. Eur Heart J. 2006;27(14):1678-1684.

24. Elesber AA, Conover CA, Denktas AE, Lennon RJ, Holmes DR, Jr., Overgaard MT, Christiansen

M, Oxvig C, Lerman LO and Lerman A. Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. European heart journal. 2006;27:1678-84

25. Denktas AE. Bridge over troubled coronary artery/Muscular bridge causing non-ST-segment

elevation myocardial infarction. Letter to the Editor: Anatolian Journal of Cardiology 2007;7:99-100.

26. Assali AR, Moustapha A, Sdringola S, Denktas AE, Willerson JT, Holmes DR, Smalling RW.

Acute coronary syndrome may occur with in-stent restenosis and is associated with adverse outcomes (The PRESTO trial). American Journal of Cardiology 2006;98 (6): 729-733.

27. Smalling RW, Giesler GM, Julapalli VR, Denktas AE, Sdringola S, Vooletich MT, McCarthy JJ,

Bradley RN, Persse DE, Richter BK, Yagi M, Fujise K, Anderson HV. Pre-hospital reduced-dose fibrinolysis coupled with urgent percutaneous coronary intervention reduces time to reperfusion and improves angiographic perfusion score compared with prehospital fibrinolysis alone or primary percutaneous coronary intervention: results of the PATCAR Pilot Trial. J Am Coll Cardiol. 2007;50(16):1612-1614.


28. Persse DE, McCarthy JJ, Vooletich M, Richter BK, Anderson HV, Denktas AE, Sdringola S, and Smalling RW. 2008 Prehospital Fibrinolysis in concert with rapid PCI. Clinical trial shows promising results for use of clot-dissolving agents in the field. JEMS 2008;33:74-88.

29. Anderson HV, Denktas AE, Smalling RW, Sdringola S, Vooletich MT. Reperfusion strategies in

ST-elevation myocardial infarction. Am J Cardiol, Jan 2009;103:284-6 30. Denktas AE, Athar H, Henry TD, Larson DM, Simons M, Chan RS, Niles NW, Thiele H, Schuler

G, Ahn C, Sdringola S, Anderson HV, McKay RG and Smalling RW. Reduced-dose fibrinolytic acceleration of ST-segment elevation myocardial infarction treatment coupled with urgent percutaneous coronary intervention compared to primary percutaneous coronary intervention alone results of the AMICO (Alliance for Myocardial Infarction Care Optimization) Registry. JACC Cardiovascular interventions. 2008;1:504-10.

31. Yeter E, Denktas AE. Pre-Hospital Fibrinolytic Therapy Followed by Urgent Percutaneous

Coronary Intervention in Patients with ST Elevation Myocardial Infarction. Future Cardiol. 2009 Jul;5(4):403-11.

32. Yeter E, Kurt M, Silay Y, Anderson HV, Denktas AE. Drug-eluting stents for acute myocardial

infarction. Expert Opin Pharmacother. 2009:10(1):19-34. 33. Yeter E, Denktas AE. PATCAR: A New Standard of Care to Reduce the Chance of Death in Heart

Attack Victims. Therapy, 2009 6(3), 383–385. 34. Wang H, Escobar JM, Denktas AE. Pre-Hospital Fibrinolytic Therapy for ST-Elevation Acute

Myocardial Infarction. Current Cardiovascular Risk Reports, 2009; Vol 3, Issue 5. 35. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, Gerstenblith G, Demaria AN,

Denktas AE, Gammon RS, Hermiller JB Jr, Reisman MA, Schaer GL, Sherman W A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009; 54:2277-86.

36. Denktas, AE. Primary percutaneous coronary intervention in ST-segment elevation myocardial

infarction is more effective than fibrinolysis at reducing the composite outcome of death or reinfarction after 8 years. Evidence-based medicine. 2010;15:145-6.

37. Huynh T, Birkhead J, Huber K, O’Loughlin J, Stenestrand U, Weston C, Jernberg T, Schull M,

Welsh RC, Denktas AE, Travers A, Sookram S, Theroux P, Tu JV, Timmis A, Smalling RW, Danchin N. The Pre-Hospital Fibrinolysis Experience in Europe and North America and Implications for Wider Dissemination. J Am Coll Cardiol Cardiovasc Interv 2011 Aug; 4(8):877-83.

38. Aertker RA, Barker CM, Anderson HV, Denktas AE, Giesler GM, Julapalli VR, Ledoux JF, Persse

DE, Sdringola S, Vooletich MT, McCarthy JJ, Smalling RW. Prehospital 12-Lead Electrocardiogram within 60 Minutes Differentiates Proximal versus Nonproximal Left Anterior Descending Artery Myocardial Infarction. West J Emerg Med. 2011 Nov;12(4):408-13.

39. Denktas AE, Anderson HV, McCarthy J, Smalling RW. Total Ischemic Time: The Correct Focus

of Attention for Optimal STEMI Care. J Am Coll Cardiol Intv 4: 2011; 599-604. 40. Denktas AE, Anderson HV, McCarthy JJ, Smalling RW. Reply. JACC: Cardiovascular

Interventions 2011;4:1051-1052.


41. Comparison of In-Hospital Outcomes With Low-Dose Fibrinolytic Therapy Followed by Urgent Percutaneous Coronary Intervention Versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction. Bhatt NS, Solhpour A, Balan P, Barekatain A, McCarthy JJ, Sdringola S, Denktas AE, Smalling RW, Anderson HV. Am J Cardiol. 2013;111(11):1576-9.

42. Gulbis BE, Ruiz MC, Denktas, AE. The Impact of Drug Shortages on the Pharmacy, Nursing, and

Medical Staff’s Ability to Effectively Care for Critically Ill Patients. Crit Care Nurs Q 2013; 36(4):400-406.

43. Lim M, Arslan Z, Cai C, Kim CY, Geng Y-J and Denktas AE. Total Ischemic Time as an

Independent Predictor of Response to Stem Cell Therapy in Patients with ST Segment Elevation Myocardial Infarction. ISRN Stem Cells. 2014;2014:13.

44. Solhpour A, Chang KW, Balan P, Cai C, Sdringola S, Denktas AE, Smalling RW, Anderson HV.

Comparison of outcomes for patients ≥75 years of age treated with pre-hospital reduced-dose fibrinolysis followed by percutaneous coronary intervention versus percutaneous coronary intervention alone for treatment of ST-elevation myocardial infarction. Am J Cardiol. 2014;113(1):60-3.

45. Denktas AE, Anderson HV TAVI in Patients with LV Dysfunction: Worse Outcomes or Greatest

Chance for Improvement? Journal of Interventional Cardiology 2014;26(3):139. 46. Kitkungvan D and Denktas AE. Cardiac arrest and ventricular tachycardia from coronary

embolism: an unusual presentation of infective endocarditis. Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology. 2014;14:204-5.

47. Pershad A, Fraij G, Massaro JM, David SW, Kleiman NS, Denktas AE, Wilson BH, Dixon SR,

Ohman EM, Douglas PS, Moses JW and O'Neill WW. Comparison of the use of hemodynamic support in patients >/=80 years versus patients


52. Kumar A, Paniagua D, Hira RS, Alam M, Denktas AE and Jneid H. Balloon Aortic Valvuloplasty in the Transcatheter Aortic Valve Replacement Era. The Journal of invasive cardiology. 2016;28:341-8.

53. Ma TS, Paniagua D, Denktas AE, Jneid H, Kar B, Chan W and Bozkurt B. Usefulness of the Sum

of Pulmonary Capillary Wedge Pressure and Right Atrial Pressure as a Congestion Index that Prognosticates Heart Failure Survival (from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness Trial). The American journal of cardiology. 2016;118:854-9.

54. Khalid U, Jneid H and Denktas AE. The relationship between total ischemic time and mortality in

patients with STEMI: every second counts. Cardiovasc Diagn Ther. 2017 Jun;7(Suppl 2):S119-S124.

55. Denktas AE, Paniagua D and Jneid H. Renal denervation: Are we on the right path? Cleve Clin J

Med. 2017;84:687-689 56. Levine GN, Dai X, Henry TD, Calfon Press M, Denktas AE, Garberich RF, Jacobs AK, Jaski BE,

Kaul P, Kontos MC, Stouffer GA, Smith SC, Jr. and In-Hospital SQIP. In-Hospital ST-Segment Elevation Myocardial Infarction: Improving Diagnosis, Triage, and Treatment. JAMA Cardiol. 2018;3(6):527-31.

57. Thamwiwat A, Sudhakar D, Paniagua D, Denktas AE. Suspected coronary fat embolism after

liposuction. Catheter Cardiovasc Interv. 2018;00:1–4. 58. Khalid U, Jneid H and Denktas AE. Prehospital fibrinolysis followed by urgent percutaneous

coronary intervention after ST-elevation myocardial infarction. Future Cardiol. 2018;14(3):193-5. 59. Basra SS, Wang TY, Simon DN, Chiswell K, Virani SS, Alam M, Nambi V, Denktas AE, Deswal

A, Bozkurt B, Ballantyne CM, Peterson ED and Jneid H. Ticagrelor Use in Acute Myocardial Infarction: Insights From the National Cardiovascular Data Registry. J Am Heart Assoc. 2018;7:e008125; originally published June 9, 2018; doi: 10.1161/JAHA.117.008125

60. Kayani WT, Blaustein A, Denktas A, Jneid H. Transcatheter aortic valve replacement for bicuspid

aortic valve stenosis. Cleve Clin J Med. 2018;85(10):786-8. Manuscripts for multicenter trials where Dr. Denktas’ contribution is acknowledged in the investigators

section: 1. Weisbord SD, Gallagher M, Jneid H, Garcia S, Cass A, Thwin SS, Conner TA, Chertow GM, Bhatt

DL, Shunk K, Parikh CR, McFalls EO, Brophy M, Ferguson R, Wu H, Androsenko M, Myles J, Kaufman J, Palevsky PM and Group PT. Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine. N Engl J Med. 2018;378:603-614.

2. Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS, Tirschwell DL and Investigators R. Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke. N Engl J Med. 2017;377:1022-1032.

3. Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK, Thourani VH, Tuzcu EM, Miller DC, Herrmann HC, Doshi D, Cohen DJ, Pichard AD, Kapadia S, Dewey T, Babaliaros V, Szeto WY, Williams MR, Kereiakes D, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Moses JW, Trento A, Brown DL, Fearon WF, Pibarot P, Hahn RT, Jaber WA, Anderson WN, Alu MC, Webb JG and Investigators P. Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients. N Engl J Med. 2016;374:1609-20.


4. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL and Investigators SH-. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370:1393-401.

5. Farkouh ME, Domanski M, Sleeper LA, Siami FS, Dangas G, Mack M, Yang M, Cohen DJ, Rosenberg Y, Solomon SD, Desai AS, Gersh BJ, Magnuson EA, Lansky A, Boineau R, Weinberger J, Ramanathan K, Sousa JE, Rankin J, Bhargava B, Buse J, Hueb W, Smith CR, Muratov V, Bansilal S, King S, 3rd, Bertrand M, Fuster V and Investigators FT. Strategies for multivessel revascularization in patients with diabetes. N Engl J Med. 2012;367:2375-84.

Manuscripts published by the ACC Committees Dr. Denktas participates 1. Tracy CM, Crossley GH, Bunch TJ, Chow GV, Leiserowitz A, Indik JH, Kusumoto F, Mendes

LA, Munger TM, Murali S, Patton KK, Russo AM, Scheinman M, Schoenhard JA and Winterfield JR. 2017 ACC/HRS Lifelong Learning Statement for Clinical Cardiac Electrophysiology Specialists: A Report of the ACC Competency Management Committee. Journal of the American College of Cardiology. 2018;71:231-250. 2. Tracy CM, Crossley GH, Bunch TJ, Chow GV, Leiserowitz A, Indik JH, Kusumoto F, Mendes LA, Munger TM, Murali S, Patton KK, Russo AM, Scheinman M, Schoenhard JA and Winterfield JR. 2017 ACC/HRS lifelong learning statement for clinical cardiac electrophysiology specialists: A report of the ACC Competency Management Committee. Heart Rhythm. 2018;15:e17-e34.

b. Accepted/In Press

2. Full Papers Without Peer Review a. Published b. In Preparation

3. Abstracts Given During Last Three Years

1. Kokmen E, Denktas AE, Erez S: Uzman, Lutfu, Lahut (1923-1962) – A life in neurology. Ann Neurol. 34(2):320, Aug 1993.

2. Smalling RW, Denktas AE, Cafri CJ, Cohen AM, Maklad NF, Raval B, Rosales OR, Ruiz CE. Abdominal aortic aneurysm repair by percutaneous implantation of wire mesh stents and coil embolization of the aneurysm. ACC99 48th Annual Scientific Session, Mar 6-10, 1999.

3. Cafri CJ, Denktas AE, Rosales OR, Schroth G, Fujise K, Anderson HV, Smalling RW. Real life experience with arterial sealing devices: Is manual pressure obsolete? XXIst Congress of the European Society of Cardiology, Barcelona, Spain, Aug 28-Sept 1,1999.

4. Denktas AE, Cafri C, Mamdani ST, Rosales OR, Fujise K, Schroth G, Anderson HV, Smalling RW. Do sealing devices after vascular interventions make a difference in clinical practice? J Am Coll Cardiol. 35(2):33A Suppl 1, Feb 2000.

5. Denktas AE, Cohen AM, Cafri C, Assali A, Sdringola S, Rhiner MA, Maklad NF, Raval B, Schroth G, Anderson HV, Rosales OR, de la Guardia B, Smalling RW. Comparison of abdominal aortic aneurysm repair by percutaneous implantation of uncovererd wire mesh stents and coil embolization of the aneurysm cavity in patients with and without pre-existing thrombus. J Am Coll Cardiol. 35(2):23A Suppl 1, Feb 2000.

6. Assali AR, Sdringola S, Ghani M, Westbrook LA, Denktas AE, Anderson HV, Schroth G, Rosales OR, Fujise K, Smalling RW. Timing of coronary stent thrombosis in patients treated with a prophylactic short-acting IIb/IIIa inhibitor. The Society for Cardiac Angiography and Interventions 23rd Annual Meeting, May 3-6, 2000.

7. Assali AR, Sdringola S, Ghani M, Denktas AE, Anderson HV, Schroth G, Rosales OR, Fujise K, Smalling RW. Adenosine Use During Aortocoronary Vein Graft Interventions Reverses But


Does Not Prevent The Slow-No Flow Phenomenon. The Society for Cardiac Angiography and Interventions 23rd Annual Meeting, May 3-6, 2000.

8. Denktas AE, Ghani MK, Mamdani ST, Haley D, Diaz S, Cafri CJ, Barasch E. Decreased ejection fraction predicts in-hospital mortality in patients with intracranial hemorrhage. American Society of Echocardiography 11th Annual Scientific Sessions, Chicago, IL, Jun 11-14, 2000.

9. Denktas AE, Rihner MA, Achour H, Amirian J, Felli P, Navarro P, Barasch E, Buja LM, Smalling RW. End-diastolic wall thickness immediately post-reperfusion is a measure of irreversible damage in reperfusion strategies for acute myocardial infarction. Eur Heart J. 21:P523 Suppl S, Aug-Sept 2000.

10. Aschour H, Denktas AE, Assail A, Amirian J, Felli P, Buja LM, Uthman M, Smalling RW. Protective effects of adenosine on myocardial ischemia and reperfusion in the dogs. J Am Coll Cardiol. 37(2):346A Suppl 1, Feb 2001.

11. Denktas AE, Shogren K, Holmes DR Jr, Bayes-Genis A, Oxvig C, Overgaard MT, Christiansen M, Conover CA, Schwartz RS. Pregnancy associated plasma protein-A is preferentially expressed in plaque of patients with restinosis. J Am Coll Cardiol. 39(5):19A-20A Suppl A, Mar 2002.

12. Barcin C, Denktas AE, Garratt KN, Higano ST, Holmes DR Jr, Lerman A. TIMI frame count index successfully identifies the patients with endothelial dysfunction. Eur Heart J. 23:466 Suppl S, Aug-Sept 2002.

13. Denktas AE, Best PJM, Woodrum JE, Overgaard MT, Oxvig C, Holmes DR Jr, Conover CA, Lerman A. Pregnancy associated plasma protein-A levels are elevated in patients with unstable angina. Eur Heart J. 23:466 Suppl S, Aug-Sept 2002.

14. Barcin C, Denktas AE, Garratt KN, Higano ST, Holmes DR Jr, Lerman A. Change in TIMI frame count correlates with the change in coronary flow parameters. Eur Heart J. 23:68 Suppl S, Aug-Sept 2002.

15. Orford JK, Denktas AE, Fasseas P, Berger PB, Holmes DR Jr. Intravascular ultrasound guided coronary stenting is not associated with improved outcomes at nine months: An analysis of 11, 482 patients. Circulation. 106(19):2895 Suppl S, Nov 5, 2002.

16. Barcin C, Denktas AE, Lennon RJ, Hammes L, Lerman A, Holmes DR Jr, Garratt KN. Restoration of normal coronary flow after no-reflow phenomenon does not improve post-procedural myocardial infarction in patients without ST-segment elevation myocardial infarction. J Am Coll Cardiol. 41(6):10A-11A Suppl A, Mar 19, 2003.

17. Orford JL, Fasseas P, Panetta CJ, Denktas AE, Holmes DR Jr, Berger PB. Incidence, management, and outcomes of coronary perforation: An analysis of 16,298 patients. J Am Coll Cardiol. 41(6):72A Suppl A, Mar 19, 2003.

18. Denktas AE, Orford JL, Fasseas P, Barcin C, Lennon RJ, Lerman A, Holmes DR Jr. Multivessel percutaneous intervention for ST-segment elevation myocardial infarction: The Mayo Clinic experience. J Am Coll Cardiol. 41(6):324A Suppl A, Mar 19, 2003.

19. Denktas AE, Best PJM, Woodrum JE, Overgaard MT, Christiansen M, Oxvig C, Holmes DR Jr, Conover CA, Lerman A. Pregnancy associated plasma protein-A levels are elevated in patients with unstable angina. J Am Coll Cardiol. 41(6):339A Suppl A, Mar 19, 2003.

20. Barcin C, Denktas AE, Lennon RJ, Hammes LV, Higano ST, Holmes DR Jr, Garratt KN, Lerman A. Combination therapy of adenosine and nitroprusside is better than adenosine alone in the treatment of angiographic no-reflow phenomenon. Eur Heart J. 24:636 Suppl A, Aug-Sept 2003.


21. Giesler GM, Vooletich MT, Julapalli V, Garg R, Rester J, Anderson HV, Sdringola S, Denktas AE, Bradley R, Persse D, Smalling RW. Coordinated aggressive medical and interventional therapy for acute myocardial infarction: Pre-hospital administration of thrombolysis with urgent culprit artery revascularization (PATCAR). American Journal of Cardiology. Oct 2005;96(7A):56H-56H.

22. Iliescu C, Giesler GM, Hemstreet PG, Murtagh B, Liu WY, Gomez J, Fuentes F, Anderson HV, Denktas AE, Smalling RW. Natural catastrophic events are associated with increased incidence and severity of acute coronary syndromes. Journal of the American College of Cardiology. Feb 2006;47(4):171A-171A.

23. Effect of the aotologous transplantation of endothelial progenitor cells after acute myocardial infarction Dagdelen S, Altiok E, Denktas A, Yuce M, Eren N, Unsal I, Canpolat N, Caglar N European Heart Journal 27: 277-277 Suppl. 1, AUG 2006

24. Giesler GM, Vooletich MT, Julapalli V, Garg R, Rester J, Anderson HV, Sdringola S, Denktas AE, Bradley R, Persse D, Smalling RW. Coordinated aggressive medical and interventional therapy for acute myocardial infarction: Pre-hospital administration of thrombolysis with urgent culprit artery revascularization (PATCAR). European Heart Journal 27: 908-908 Suppl. 1, AUG 2006

25. Agarwal R , LeDoux J, Giesler G, Vooletich MT, Sdringola S, Anderson HV, Denktas AE, Smalling RW. Early initiation of reperfusion therapy within 60 minutes of onset of symptoms dramatically reduces infarct size by cardiac MRI American Journal of Cardiology, 98 (8A): 84M-84M Suppl. S, OCT 22 2006

26. Denktas AE, Loghin C, Murtagh B (Murtagh, Blaithnead), LeDoux JF, Giesler G, Gomez J, Smalling RW. Ablation of the septum by coil embolization of the septal peforator is a new potential treatment option for patients with symptomatic hypertrophic obstructive cardiomyopathy. American Journal of Cardiology 98 (8A): 231M-232M Suppl. S, OCT 22 2006

27. Giesler GM, Vooletich MT, Julapalli VR, Denktas AE, Anderson HV, Sdringola S, McCarthy JJ, Bradley RN, Persse DE, Smalling RW. Reduction in time to reperfusion and improved myocardial perfusion with pre-hospital facilitated coronary intervention compared to primary PCI in STEMI patients treated in an urban setting CIRCULATION 114 (18): 424-424 Suppl. S, OCT 31 2006

28. McCarthy JJ, Vooletich MT, Julapali VR, Geisler GM, Richter B, David W, Bradley RN, Persse DE, Sdringola S, Denktas AE, Anderson HV, and Smalling RW. 2006 Implementation of a team-based approach for the management of ST elevation myocardial infarction improves symptom onset to treatment time. Circulation. 114:464-464 Suppl. S, OCT 31 2006

29. Abbas A, Gulbis BE, Hall AC, Liu WY, Landrau CW, Reyes MM, Pham CT, Kaynak HE, McCarthy JJ, Persse DE, Sdringola S, Anderson HV, Smalling RW, and Denktas AE. An integrated approach to the treatment of sudden cardiac death improves survival in an urban setting. Journal of the American College of Cardiology. 49:230A-230A 2007.

30. Hall AC, Gulbis BE, Abbas A, Liu EY, Landrau CE, Reyes MM, Pham CT, Kaynak HE, McCarthy JJ, Persse DE, Sdringola S, Anderson HV, Smalling RW, and Denktas AE. Therapeutic hypothermia for out-of hospital cardiac arrest may not improve survival when utilized in an unselected population. Journal of the American College of Cardiology. 49:246A-246A 2007.

31. Zambrano J, Traverse JH, Henry T, Dib N, Strumpf R, Schulman S, Gerstenblith G, DeMaria A, Denktas AE, Gammon R, Hermiller J, Reisman M, Schaer G, Sherman W, Tamariz LJ, and Hare J. The impact of intravenous allogeneic human mesenchymal stem cells (provacel (TM)) on ejection fraction in patients with myocardial infarction. Circulation. 116:202-202 2007.


32. Anderson HV, Denktas AE, Henry TD, Thiele H, Sdringola S, Niles NW, McKay RG, and Smalling RW. Pre-hospital 1/2-dose fibrinolytic therapy coupled with immediate PCI vs primary PCI in diabetics: AMICO registry. Journal of the American College of Cardiology. 51:B68-B68 2008.

33. Bhalla K, Sanon S, Smalling R, Denktas AE. Septal Ablation Using Detachable Coils May Be A Useful Alternative For The Treatment Of Patients With Symptomatic Hypertrophic Obstructive Cardiomyopathy. American Journal of Cardiology 2008;102:4I-4I.

34. Barker CM, Torres L, Maland D, Stautberg E, LeDoux J, Loghin C, Weirick T, Denktas AE, Anderson HV, Sdringola S, Smalling RW. ACC Poster Contributions: 1047. Acute Myocardial Infarction--Can Primary PCI Be Facilitated? Pre-Hospital Fibrinolysis Followed By Urgent Percutaneous Intervention within the First Two Hours of STEMI Are Associated With a Significant Reduction in Microvascular Obstruction and Infarct Size. American College of Cardiology Annual Conference, Atlanta, GA, March 14, 2010

35. Weirick T, Barker CM, LeDoux J, Maland D, Stautberg E, Denktas AE, Sdringola S, Anderson HV, Loghin C, McCarthy J, Persse D, Vooletich M, Smalling RW. i2 Poster Contributions: 2501. DES I, ACS, AMI and Vulnerable Plaque: Pre-hospital Reduced-dose Fibrinolytic Therapy Followed by Emergent Percutaneous Intervention Reduces Infarct Size and Limits Microvascular Obstruction in Patients Treated Within Six Hours of STEMI Onset Without a Bleeding Penalty. American College of Cardiology Annual Conference, Atlanta, GA, March 14, 2010

36. Arslan Z, Hossain M, Geng YJ, Denktas AE. Total Ischemic Time is an Independent Predictor of Response to Stem Cell Therapy in Patients with STEMI. Journal of the American College of Cardiology 2011;57:E981.

37. Arslan Z, Shelat H, Denktas AE, Geng YJ. OP-099 A Cardiac Arrest/Resuscitation Model in Mouse for Stem Cell Therapy. International journal of cardiology 2012;155, Supplement 1:S17.

38. Arslan Z, Tavlasoglu M, Denktas AE, Geng YJ. OP-160 Catheterization of Femoral Vein in Mice for Long Term Survival Model Use. International journal of cardiology 2012;155, Supplement 1:S38-S39.

39. Balan P, Denktas A, Smalling R. Septal Coiling for Hypertrophic Obstructive Cardiomyopathy. Journal of the American College of Cardiology 2012;59:E1566.

40. Barker CM, Torres L, Maland D et al. Pre-Hospital Fibrinolysis Followed by Urgent Percutaneous Intervention within the First Two Hours Of STEMI are Associated With a Significant Reduction in Microvascular Obstruction and Infarct Size. Journal of the American College of Cardiology 2010;55:A103.E965.

41. Kelly DP, McCarthy JJ, Weirick T et al. 36: Out-of-Hospital Initiated Reperfusion for ST-Elevation Myocardial Infarction Patients: Successful Implementation of an Out-of-Hospital Thrombolytic Strategy Coupled With Urgent PCI for Reducing Myocardial Ischemic Time In an Urban Environment. Annals of Emergency Medicine 2010;56:S13.

42. Weirick T, Barker C, LeDoux J et al. Pre-Hospital Reduced-Dose Fibrinolytic Therapy Followed by Emergent Percutaneous Intervention Reduces Infarct Size And Limits Microvascular Obstruction in Patients Treated Within Six Hours of Stemi Onset Without a Bleeding Penalty. Journal of the American College of Cardiology 2010;55:A185.E1730.

43. Arslan Z, Hossain M, Geng YJ, Denktas AE. Total Ischemic Time is an Independent Predictor of Response to Stem Cell Therapy in Patients with STEMI. American College of Cardiology Annual Conference, New Orleans, LA, April 3, 2011.


44. Comparison of Outcomes for Elderly Patients Treated With Pre-Hospital Reduced Dose Fibrinolytic Followed by Urgent Percutaneous Coronary Intervention versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction Amirreza Solhpour, Kay-Won Chang, Ali E Denktas, Prakash Balan, Stefano M Sdringola, Chunyan Cai, H Vernon Anderson, and Richard W Smalling. Circulation 2013;128:A18599

45. Comparison of Outcomes for Patients With Chronic Kidney Disease Treated With Pre-Hospital Reduced Dose Fibrinolytic Followed by Urgent Percutaneous Coronary Intervention versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction Amirreza Solhpour, Kay-Won Chang, Richard W Smalling, Stefano Sdringola, Prakash Balan, H Vernon Anderson, and Ali E Denktas. Circulation. 2013;128:A16097

46. Solhpour A, Chang K, Balan P, Sdringola S, Denktas AE, Smalling RW, Anderson HV. Ischemic Time Is a Better Mortality Predictor than Door-to-Balloon Time in Patients with ST-Elevation Myocardial Infarction; To be presented in ACC 2014 (Control#: 12166) in a Poster Contributions entitled Acute Coronary Syndromes: STEMI Mar 30 2014

47. Publication Rates of Abstracts Presented at Major Cardiovascular Subspecialty Conferences Brittany Owen, Jason Hoff, David Aguilar, Ali Denktas, Salim Virani, Nasser Lakkis, Biykem Bozkurt, Anita Deswal, Tina Shah, Arunima Misra, Hani Jneid, Christie Ballantyne, Vijay Nambi Circulation. 2016;134:A20656, originally published November 11, 2016

48. Multiple Coil Embolizations for Refractory Septal Ventricular Tachycardia D Burkland, K Koranne, I Basu Ray, A Denktas, P LeLorier, J Cheng, N Mathuria; Heart Rhythm 14 (5), S-325, May Supplement 2017

4. Books a. Complete Books Written b. Books Edited c. Book Chapters Written

1. Smalling RW, Denktas, AE. Percutaneous coronary interventional therapy for acute myocardial infarction. Cardiovascular Medicine, Second Edition; Publisher: Churchill Livingston; Editors: James T. Willerson, Jay N. Cohn; Philadelphia, PA, 2000.

2. Denktas AE, McGhie AI. Electron beam computed tomography and its uses in cardiology. Handbook of Non-invasive Cardiac Testing; Publisher: Edward Arnold Publishers Limited; Editors: A. Iain McGhie; London, UK, 2001. Pages 149-160.

3. Denktas AE, Mathew V. In-stent restenosis. Atlas of Interventional Cardiology, Second Edition; Publisher: Current Medicine Inc.; Editors: Verghese Mathew, David R. Holmes, Jr.; Philadelphia, PA, 2003.

4. Denktas AE, Holmes DR Jr. New revascularization strategies. Acute Coronary Syndromes, Companion to Braunwald’s Heart Disease. Publisher: W.B. Saunders Co.; Editors: Douglas P. Zipes, Peter Libby; Philadelphia, PA, 2003.

5. Fasseas P, Denktas AE and Berger P. Management of Unstable Angina and non-ST elevation Myocardial Infarction Pages: 97-108 Atherosclerosis and Heart Disease, Publisher: Taylor&Francis Ltd., London, 9/25/2003 Editor: Andrew Tonklin

6. Denktas AE, Singh M, Holmes DR Jr. Percutaneous Coronary Intervention Book Chapter: Surgery for Coronary Artery Disease - 2nd Edition Edward Arnold (Publishers) Limited (formerly Chapman and Hall Medical), UK 2003 Editor: David J. Wheatley

7. Mathew V, Holmes DR Jr, Altman JD, Barsness GW, Bresnahan JF, Chauhan A, Denktas AE, Farb A, Garratt KN, Higano ST, Lerman A, Lubbe DF, More RS, Rihal CS, Schwartz


RS, Singh M, Timimi FK, Virmani R. Interventional Cardiology Book Chapter: Essential Atlas of Heart Diseases Third Edition, Editor-in-Chief Eugene Braunwald, Current Medicine, Philadelphia, PA, 2006

8. Denktas AE, Jneid MH, Paniagua D, Levine GN. Percutaneous Coronary Intervention. In Illustrated Guide to Cardiovascular Disease. Levine GN (editor). Jaypee Medical Publishers, New Delhi. 2015

9. Denktas AE, Grines, C Percutaneous Coronary Intervention, Cardiology Secrets, Elsevier Saunders, Glenn Levine (editor). 2017

10. Denktas, AE Contributor to Manual of Chronic Total Occlusion Interventions, A Step-by-Step Approach, Academic Press, Emmanouil Brilakis (editor), 2017

5. Other Works Communicating Research Results to Scientific Colleagues

1. Denktas AE. Effectiveness of digoxin in heart failure patients in sinus rhythm. Second National Cardiology Student Days, Istanbul, Turkey, 4/11/1990.

2. Denktas AE, Farraj R, Geller A. Urinary Ascites: An unusual cause of ascites in adults, diagnosis and management. ACP Minnesota Chapter, Minneapolis, 11/8/1996.

3. Smalling RW, Denktas AE. An aggressive approach to the treatment of acute myocardial infarction: lessons from recent clinical trials. Cyberounds, Cardiovascular Medicine, www.cyberounds.com, 7/1/1999.

6. Other Works Communicating Research Results to General Public

1. Denktas AE. Interview: Marathon Runner Detoured by Heart Attack. http://www.39online.com/news/local/kiah-marathon-runner-heart-attack-story,0,293716.story KIAH-TV CW Channel 39, Houston, TX, January 22, 2010.

2. Denktas AE. Interview: Doctors Saves Colleague Who Had Heart Attack.

http://abclocal.go.com/ktrk/story?section=news/health&id=7949167. KTRV-TV ABC Channel 13, Houston, TX, February 9, 2011.

3. Denktas AE. Presentation: UT Health/Memorial Hermann Hospital YouTube Video “Dr. Ali

Denktas Discusses Stem Cell Treatment for Heart Attack Patients”. http://www.youtube.com/watch?v=E-JZ7Hzb8Js. UT Health, Houston, TX, February 29, 2012.

D. Innovation and Commercialization

1. Patents 2. Device, Software or Other Development 3. Evidence of Impacting Health/Scientific Policy or Clinical Practice Guidelines 4. Participation in Business Development and Commercialization 5. Other Activities

III. TEACHING INFORMATION A. Educational Leadership Roles 1. UT Internal Medicine Committee 2010-2014 B. Didactic Coursework

1. Courses Taught at BCM Within the Primary Department Mechanical Complications of STEMI (Residents on internal medicine and consult services)

Monthly


Rich Emotional Experiences in the cardiac catheterization Laboratory to cardiology fellows yearly 1a. Courses Taught before BCM Within the primary Department 2. Courses Taught at BCM External to the Primary Department 2a. Courses Taught before BCM External to the Primary Department Physical examination preceptorship: Number of hours 16 hours/academic year. 2012-2013 Preoperative cardiac evaluation: to cardiovascular residents and fellows yearly 3. Courses Taught at Other Institutions While at BCM

University of Texas McGovern Medical School Board Review Right and Left Heart Catheterization, to cardiology fellows yearly C. Curriculum Development Work

1. Course(s)/Curricula to Which Contributions Have Been Made 2. Role in Course/Curriculum Development 3. Audience(s) for Course(s)/Curricula Developed

1. Interventional Cardiology Curriculum Development. I co-developed the interventional cardiology

curriculum with the interventional cardiology program director. This was for the interventional cardiology fellows of University of Texas McGovern Medical School.

2. Cardiology Interventional Conference at the VA Hospital Primarily organized and led by me. Occurs monthly. Didactic and practical teaching case-based problem solving for the Interventional cardiology fellows.

3. I organized the M&M for cardiology fellowship for University of Texas McGovern Medical School between 2007-2014.

4. M&M Curriculum for Interventional Cardiology at BCM 2018-Present D. Non-didactic Teaching While at BCM

1. Resident Training 352 hours per academic year with 4-5 learners. 2. Clinical Fellow Training Interventional cardiology and cardiology fellows of the University of Texas Health Science Center

at the Memorial Hermann Hospital since 2005. Since 2014 one day a month catheterization laboratory teaching with general and interventional fellows.

Three interventional fellows and eight general fellows per year. 3-4 months of CCU and consult

service and 12 months of cardiac catheterization laboratory experience. Non-didactic teaching expected at BCM:

• 3 residents in CCU with 3-4 months/year rounding. • 2 Cardiology fellows and 1 Interventional fellow training at the cardiac catheterization laboratory

daily. • 7 cardiology fellow interactions during cardiology consult rotation, subspecialty seminars and

conferences. 3. The fellows mentored since 2005: Clinical: (The fellows before 2014 are UT fellows) • 2017-2018: o Thamwiwat, Alisa, Khalid, Umair, Patel, Kaushal, El-Refai, Mostafa • 2016-2017: o Kayani, Waleed, Dadu, Razvan, Grounds, Jill • 2015-2016: o Basra, Sukhdeep, Bassett, Scott, Cota, Francisco • 2014-2015: o Hira, Ravi, Kanda, Brinder, Posligua, William, Ansari, Julia • 2013-2014


o Fasulo, Mark, Sami, Shehzad, Gupta, Nishant, o Brown, Ross, Yau, Raymond, Awar, Omar, Sahai, Achal • 2012-2013 o Dib, Chadi, Daraban, Nicoleta, Kuo, Bruce • 2011-2012 o Balan, Prakash, Reyes, Manuel, Stephens, Michael • 2010-2011 o Kim, Christopher, Mohyuddin, Tayyab • 2009-2010 o Weirick, Troy, Yoho, Jason, Binu Kunjummen • 2008-2009 o Gnaim, Charlie, Ellis, Wendell, Karan, Bhalla • 2007-2008 o Iliescu, Cezar, Julapalli, Vinay, LeDoux, John • 2006-2007 o Athar, Haris, Hemstreet, George P., Liu, Wing Yi • 2005-2006 o Giesler, Greg, Gomez, Jaime, Murtagh, Blaithnead M • 2004-2005 o Eades, Brian, Muench, Andreas, Ganim, Rick

3. Research Fellow Training while at University of Texas Ekrem Yeter 2009-2010 supported by Turkish Department of Health Grant), Published 3 articles

with him and is now an Associate Professor of Cardiology in Turkey. • Iris Wang 2010-2011 (supported by Wetherhead Center Grant for Stem cell research), Published

one paper. • Zekeriye Aslan 2011-2012 (supported by the Turkish Department of Defense), Published 4 abstracts

and one paper. He is now an associate professor in Turkey. 4. Graduate Student Training 5. Medical Student Mentoring

E. Faculty Development or Continuing Medical Education

1. Current Concepts of Cardiology Course Co-Director, April 2013, Co-Developed Meeting agenda, speaker selection, funding procurement. This was a national/international meeting held in Houston with international and national experts in the field of interventional cardiology and cardiovascular surgery. F. Lectures and Presentations

1. International For international, national and regional presentations please see section II.B.5 2. National 3. Regional 4. Local 1. Denktas AE. Stem Cell Treatment of Acute Myocardial Infarction. Cardiology Grand Rounds,

University of Texas at Houston, TX, May13, 2004. 2. Denktas AE. Tips and Tricks: Renal, Iliac and Femoro popliteal Interventions. Concepts in

Contemporary Cardiology, Houston, TX, April 14, 2005. 3. Denktas AE. Cardiac Catheterization and Interventional Cardiology: Interventions: Overview.

Texas Heart Institute at St. Luke’s Episcopal Hospital “2nd Annual 2005 Texas Medical Center Cardiology Board Review”, Houston, TX, August 27, 2005.


4. Denktas AE. The Future Management of Congestive Heart Failure: Circulating Stem Cells for the Treatment of Acute Myocardial Infarction. Concepts in Contemporary Cardiology, Houston, TX, April 21, 2005.

5. The Future Management of Congestive Heart Failure: Session Moderator. Concepts in

Contemporary Cardiology, Houston, TX, 4/21/2005 6. Denktas, AE. Acute ST Elevation Myocardial Infarction. Third Annual Texas Medical Center

Cardiovascular Board Review, Houston, TX, September 5-October 26, 2006, September 14, 2006. 7. Denktas, AE. Board Approach to Angiograms. Fifth Annual Texas Medical Center Cardiovascular

Board Review, September 4-21, 2008, Houston, TX, September 16, 2008. 8. Denktas AE. Panelist: Live Case: Memorial Hermann Heart and Vascular Institute, Texas Heart

Institute, and St. Luke’s Episcopal Hospital. Concepts in Contemporary Cardiology, Houston, TX, April 15, 2009.

9. Denktas AE. Presentation: Stem Cells, Heart Failure Symposium. Concepts in Contemporary

Cardiology, Houston, TX, April 15, 2009. 10. Denktas AE. Panelist: Panel Discussion, Heart Failure Symposium. Concepts in Contemporary

Cardiology, Houston, TX, April 15, 2009. 11. Denktas AE. Panelist: Live Case: Memorial Hermann Heart and Vascular Institute, Texas Heart

Institute, and St. Luke’s Episcopal Hospital. Concepts in Contemporary Cardiology, Houston, TX, April 16, 2009.

12. Denktas AE. Presentation: HOCM Septal Ablation: The Potential for Septal Coiling, Structural

Heart Disease Symposium. Concepts in Contemporary Cardiology, Houston, TX, April 16, 2009. 13. Denktas AE. Moderator: Lunch Session: Challenging Cardiac Case Presentations by Fellow

Alumni. Concepts in Contemporary Cardiology, Houston, TX, April 16, 2009. 14. Denktas AE. Presentation: Case Presentation: Lunch Session: Challenging Cardiac Case

Presentations by Fellow Alumni. Concepts in Contemporary Cardiology, Houston, TX, April 16, 2009.

15. Denktas AE. Presentation: Stem Cell Interventions for AMI, Coronary Artery Disease Symposium.

Concepts in Contemporary Cardiology, Houston, TX, April 16, 2009. 16. Denktas AE. Presentation: PCI in high risk patients: The role of LV support. MD Anderson Cancer

Center Cardiology Grand Rounds, Houston, TX, November 11, 2009. 17. Denktas AE. Presentation: Incidence of Infection in Patients with Sudden Cardiac Death Admitted

to a Coronary Care Unit 2009. Quality Symposium Physician Leadership Academy Graduation, November 18, 2009.

18. Denktas AE. Presentation: Coil Septal Ablation for IHSS. Concepts in Contemporary Cardiology,

Houston, TX, April 8, 2010. 19. Denktas AE. Moderator: Endovascular Management of Adult Congenital Heart Disease. Concepts

in Contemporary Cardiology, Houston, TX, April 8, 2010.


20. Denktas AE. Operator/Discussant: Taped Cases. Concepts in Contemporary Cardiology, Houston,

TX, April 9, 2010. 21. Denktas AE. Presentation: Diagnosis and Management of Acute MI. Fellows Bootcamp-Get the

Basics-Methodist DeBakey Heart and Vascular Center, Houston, Texas, August 21, 2010. 22. Denktas AE. Presentation: Percutaneous Coronary Intervention. Fellows Bootcamp-Get the Basics-

Methodist DeBakey Heart and Vascular Center, Houston, Texas, August 21, 2010. 23. Denktas AE. Presentation: High Risk Supported PCI: Which Device for Which Patient? Concepts

in Contemporary Cardiology, Houston, TX, April 29, 2011. 24. Denktas AE. Panelist: Live Case – Radial Case at Memorial Hermann Heart and Vascular Institute.

Concepts in Contemporary Cardiology, Houston, TX, April 29, 2011. 25. Denktas AE. Presentation: Pre-Hospital Fibrinolysis: Is it Ready for Prime Time? Concepts in

Contemporary Cardiology, Houston, TX, April 29, 2011. 26. Denktas AE. Presentation: Taped Case – Supported PCI from UT-Health and Memorial Hermann

Heart and Vascular Institute. Concepts in Contemporary Cardiology, Houston, TX, April 29, 2011. 27. Denktas AE. Panelist: Panel Discussion on STEMI Center Organization Strategies. Concepts in

Contemporary Cardiology, Houston, TX, April 29, 2011. 28. Denktas AE. Presentation: Diagnosis and Management of Acute MI. Fellows Bootcamp Methodist

DeBakey Heart and Vascular Center, Houston, Texas, August 4, 2012. 29. Denktas AE. Moderator: STEMI Symposium, Concepts in Contemporary Cardiology, Houston,

TX, May 3, 2012. 30. Denktas AE. Presentation FAST-PCI: The Key to Reducing Ischemic Times: STEMI Symposium,

Concepts in Contemporary Cardiology, Houston, TX, May 3, 2012. 31. Denktas AE. Panelist: Panel Discussion: What Are the Next Steps for Developing STEMI Systems

of Care? Concepts in Contemporary Cardiology, Houston, TX, May 3, 2012. 32. Denktas AE. Presentation: Interventional Treatment of Resistant Hypertension. MD Anderson

Cancer Center Cardiology Grand Rounds, Houston, TX, October 24, 2012. 33. Denktas AE. Presentation: Diagnosis, Management of Acute MI. Cardiovascular Fellows’

Bootcamp, Houston, TX, August 16-18, 2013. 34. Denktas AE. Presentation: Renal Sympathetic Denervation. Department of Cardiothoracic and

Vascular Surgery Grand Rounds Conference, UTHealth, Houston, TX, September 27, 2013. 35. Denktas, AE. Presentation: Stem Cell Therapies for STEMI Patients. 2013 Houston STEMI

Conference “STEMI: The New 90 – Meeting the E2B Challenge.” Rice University – Bioscience Research Collaborative, Houston, TX, October 3-4, 2013.

36. Denktas, AE Presentation: Coronary angiography and Ventriculography for the boards UT Health

Board Review Course, Houston, TX, September 30, 2014


37. Denktas, AE Presentation: Case Studies in Antiplatelet Medications 2014 Texas STEMI Conference

Rice University – Bioscience Research Collaborative, Houston, TX, October 16-17, 2014. 38. Denktas, AE Presentation: Debate Protagonist: Pre Hospital Fibrinolysis Ready for Prime-Time2014

Texas STEMI Conference Rice University – Bioscience Research Collaborative, Houston, TX, October 16-17, 2014.

39. Denktas, AE Presentation: Right and Left Heart Cardiac Catheterization, UT Fellows Board Review

Course, October 4, 2016 40. Denktas, AE Presentation: Chronic Total Occlusion: What Does it Have in Common with Total

Knee Replacement, University of Texas McGovern Medical School Cardiology Grand Rounds, October 5, 2016

41. Denktas, AE Presentation: Right and Left Heart Cardiac Catheterization, UT Fellows Board Review

Course, September 19, 2017 42. Denktas, AE, Protected PCI case presentation and discussion, Texas Heart Institute Cardiac Society

Tenth Symposium and The Igor F. Palacios Distinguished Lectureship in Cardiology, May 11, 2018 G. Visiting Professorships (include location, dates)

IV. PATIENT CARE AND CLINICAL CONTRIBUTIONS A. Patient Care Responsibilities

1. Department-wide • Attending Cardiologist at the Michael E. DeBakey VA Medical Center • Attending Cardiologist Memorial Hermann Hospital, • Memorial Hermann South East Hospital, • Attending Cardiologist at CHI Baylor St.Luke’s Medical Center 2. Section or Specialty: Cardiology/Interventional Cardiology 3. Clinical Service Half day of clinic weekly at the MEDVAMC, and every other week full day clinic at Baylor Clinic,

Houston VA is > 70th percentile of the national productivity measure (8412) based on most recent data for FY17. My productivity only at the VA was 8640.

B. Clinical Leadership or Business Development (describe roles and documented outcomes) Director, Cardiac Catheterization Laboratory, MEDVAMC

Largest VA catheterization laboratory in the country with excellent clinical outcomes and a portfolio that encompasses the entire interventional spectrum.

C. Voluntary Health Organization Participation D. Contributions, Initiatives or Recognition Related to Patient Safety and Healthcare Quality Improvement of patient safety in inpatient STEMI response. We assessed the previous decade of

STEMI care in the inpatient setting of the VA hospital and implemented inpatient STEMI activation protocol for the entire hospital. Since then not a single inpatient STEMI was missed.

I also wrote the STEMI response protocol for the VA hospital.


Prior to BCM appointment, we developed the STEMI protocol for Memorial Hermann Hospital as well as the cooling protocol for out of hospital cardiac arrest patients.

E. Contributions to Health and Science Policy

V. SERVICE CONTRIBUTIONS A. Administrative Assignments and Committees

1. Department or Center Administration, Committees, etc. Prior to BCM:

• Medical Director, UT Physicians Cardiovascular Medicine Clinic UT Professional Building, TMC 2008 – Jan 12, 2014

• Electronic Health Record Governance Committee, 2011 – Jan 12, 2014 • Core Faculty Internal Medicine Residency Program University of Texas Health Science

Center at Houston (UT Health) and Competency Committee member 2010- Jan 12, 2014 • Medical Director, Chest Pain Center, Memorial Hermann Hospital Texas Medical Center

At BCM: • Director, Cardiac Catheterization Laboratory, Michael E. DeBakey VA Medical Center

2014-Present 2. Institution-wide or School Administration, Committees, etc. Prior to BCM:

• Quality Action Team, Memorial Hermann Hospital 2008-2014 • MH-TMC/MHH MIC (Medical Informatics Committee) Member 2012-2014 • Pharmacy and Therapeutics Committee Member 2012-2014 • Memorial Hermann MHMD Cardiology Clinical Practice Committee 2008-2014 • Memorial Hermann Cardiology Interventional Committee 2009- Present

While at BCM: • Memorial Hermann Medical Staff Quality Review Committee 2014- 2018 • Michael E. DeBakey VA Hospital Cardiac Catheterization Quality Committee, 2018-

Present • COIN Committee Member, Michael E. DeBakey VA Medical Center

B. National, Regional or Local Participation in Professional or Voluntary Organizations • ACC Exhibits Committee member 2015-Present • ACC Anticoagulation workgroup member 2015-2018 • ACC Competency Management Committee member 2018-Present • SCAI Education Committee member 2018-Present • ACC Federal Section Leadership Council member 2019-Present

Documents

Curriculum Vitae Ali Emin Denktas, MD, FACC, FSCAI · 2020. 4. 17. · Fibrinolytic Acceleration of STEMI Treatment followed by urgent PCI (FAST-PCI) strategy on the mortality, re-infarction,