The 3The 3rdrd Generation of Target Intelligence: Generation of Target Intelligence:

Literature Analytics & AlertsLiterature Analytics & Alerts

Jim Jacketti

Current BioData Ltd

Who benefits from Who benefits from Literature Alerts & Analytics?Literature Alerts & Analytics?

Knowledge Management Scientists involved in all aspects of Target Identification and Target

Validation (TI/TV) - provides a perspective on newly published, emerging biological

knowledge that is drug discovery-centric- provides daily curated literature that focuses on proteins/genes and

their relationship to human diseases- highly efficient (time saving) current awareness tool providing both

qualitative & quantitative filters on thousands of references and patents published daily on targets and biomarkers

- also available as RSS summaries or a detailed XML data-feed can be incorporated into your intranet, delivered by FTP or via a web service API.

Curated literature can be Curated literature can be filtered by Disease filtered by Disease Category or a list of High Category or a list of High Interest Diseases Interest Diseases (customizable for (customizable for corporate clients).corporate clients).

You can also filter by You can also filter by date, type of literature date, type of literature (articles, patents, and (articles, patents, and soon posters) as well as soon posters) as well as “link status” (described “link status” (described on next slide).on next slide).

Each record shows the Each record shows the proteins/genes identified, proteins/genes identified, any any

protein<->disease links protein<->disease links studied and the “link studied and the “link status” resulting from our status” resulting from our analysis of these links.analysis of these links.

Over 120,000 protein-disease links have been identified in the curated Over 120,000 protein-disease links have been identified in the curated literature.literature. Each of these has been classified into one of six categories, based on the Each of these has been classified into one of six categories, based on the number and temporal distribution of articles (since 1998) that provide some number and temporal distribution of articles (since 1998) that provide some evidence of the linkage. evidence of the linkage. Every protein-disease link identified in a newly published article is then Every protein-disease link identified in a newly published article is then assessed and assigned to one of these six disease-link categories.assessed and assigned to one of these six disease-link categories.

BENEFIT: SCIENTISTS SAVE TIME by APPLYING THESE POWERFUL FILTERS TO IDENTIFY THE LITERATURE THAT POTENTIALLY HAS THE

GREATEST IMPACT ON THEIR RESEARCH.

Articles can easily Articles can easily be filtered to show be filtered to show only those linking only those linking a protein/gene to a protein/gene to diseases of diseases of interest. interest.

Optionally, the Optionally, the selection can be selection can be further refined to further refined to show articles show articles recommended by recommended by the 10,000+ Key the 10,000+ Key Opinion Leaders in Opinion Leaders in Biology & Medicine Biology & Medicine that are members that are members of F1000.of F1000.

The F1000 ‘article The F1000 ‘article factors’ provide an factors’ provide an additional ranking additional ranking status, identifying status, identifying the most highly the most highly recommended recommended articles.articles.

In the detail display for an In the detail display for an article, LAA shows the article, LAA shows the results of 3 analyses:results of 3 analyses:

Analytic 1 Analytic 1 identifies and standardizes identifies and standardizes the names of proteins, diseases, bio-the names of proteins, diseases, bio-groups and institutions studied in the groups and institutions studied in the specific articlespecific article

Analytic 2 Analytic 2 tabulates the results of tabulates the results of comparing the protein<->disease links comparing the protein<->disease links studied in this article with those in all studied in this article with those in all other articles in PubMed since 1998 – other articles in PubMed since 1998 – the counts and resulting Link Status the counts and resulting Link Status category are displayedcategory are displayed

Analytic 3 Analytic 3 displays any comments displays any comments provided by members of Faculty of provided by members of Faculty of 1000 together with the overall F1000 1000 together with the overall F1000 article factor (rating)article factor (rating)

The full text of evaluations The full text of evaluations written by the Faculty of written by the Faculty of 1000 KOL’s are included in 1000 KOL’s are included in LAA.LAA.

Alternatively, you can Alternatively, you can filter the literature by filter the literature by properties of the properties of the proteins cited – their proteins cited – their Molecular Function, Molecular Function, Cellular Component Cellular Component (location) or (location) or involvement in a involvement in a Biological Process.Biological Process.

For example, For example, selecting the selecting the Molecular Function Molecular Function “kinase” will retrieve “kinase” will retrieve all curated literature all curated literature in which the authors in which the authors report studies report studies relevant to any relevant to any kinaseskinases

You can also You can also combine your combine your disease of interest, disease of interest, from either a single from either a single disease or your disease or your customized High customized High Interest Diseases Interest Diseases and group by and group by protein.protein.

For example, For example, selecting Breast selecting Breast Neoplasms and Neoplasms and group by Kinases group by Kinases (from Molecular (from Molecular Function) will Function) will retrieve all curated retrieve all curated literature which literature which reflects this as well reflects this as well as the filters ‘Last as the filters ‘Last 100 days’ and 100 days’ and ‘Growing Interest’ ‘Growing Interest’ link statuslink status

All human proteins are All human proteins are covered in LAA and covered in LAA and each has an individual each has an individual Protein Report. This Protein Report. This report summarizes all report summarizes all the information in the the information in the database, from the database, from the number of diseases, number of diseases, curated articles, curated articles, patents, drugs and patents, drugs and institutions linked to institutions linked to the specific protein.the specific protein.

Also, the report will Also, the report will show all the diseases show all the diseases linked to this linked to this protein/target and the protein/target and the link status for each. link status for each. Users can be alerted Users can be alerted on specificon specific

protein<-> disease protein<-> disease status. All tables can status. All tables can be sorted and feature be sorted and feature advanced filtering advanced filtering optionsoptions

As well as individual As well as individual Protein Reports, LAA Protein Reports, LAA includes Disease includes Disease Reports that Reports that summarizes all the summarizes all the information, from the information, from the number of curated number of curated articles, linked articles, linked proteins, drugs and proteins, drugs and institutions linked to institutions linked to the specific disease.the specific disease.

Also, the report will Also, the report will show all the show all the proteins/targets linked proteins/targets linked to this disease and the to this disease and the link status for each. link status for each. The report also shows The report also shows the Protein Categories the Protein Categories and the number of and the number of articles for each. articles for each. Again, all tables can Again, all tables can be sorted and feature be sorted and feature advanced filtering advanced filtering options.options.

Partner Discovery SystemPartner Discovery System

Who benefits from theWho benefits from thePartner Discovery System?Partner Discovery System?

Business Development & Licensing Executives External Innovation Competitor Intelligence Practitioners Research Portfolio Managers

TIS provides a unique, target-centric view on the competitive landscape of biology-based drug discovery

TIS provides a rich source of partnering opportunities for externally networked research

provides you with our exclusive Partnering Opportunity Reports identify active research centers (academic and commercial) on any given

protein/gene 17,000 target/biomarker research centers are identified and analyzed In addition, 4500 institutions that are studying investigational drugs are quantified

and qualified

Filter by single Filter by single disease or disease or Selected High Selected High Interest Diseases Interest Diseases (which can be a (which can be a combination of combination of diseases diseases customized by customized by your company)your company)

Filter by institution Filter by institution type, Tier 1,2 and 3 type, Tier 1,2 and 3 Commercial and Commercial and Tier 1,2, and 3 Tier 1,2, and 3 AcademicAcademic

Filter by location Filter by location and/or link statusand/or link status

Institution Type DefinitionsInstitution Type Definitions

CommercialCommercial--(based on R&D spend)(based on R&D spend)

• Tier 1- >$1B spendTier 1- >$1B spend• Tier 2- $100M to $1B spendTier 2- $100M to $1B spend• Tier 3- < $100M spendTier 3- < $100M spend

AcademicAcademic- - (based on # of articles (papers & patents))(based on # of articles (papers & patents))

• Tier 1- > 1000 articlesTier 1- > 1000 articles• Tier 2- 100 to 1000 articlesTier 2- 100 to 1000 articles• Tier 3- < 100 articlesTier 3- < 100 articles

Filtering by High Filtering by High Interest Disease Interest Disease (Melanoma) shows (Melanoma) shows the institutions that the institutions that have published on a have published on a protein/target that is protein/target that is known to be related known to be related to melanomato melanoma

An institution may An institution may have not publically have not publically disclosed they are disclosed they are working on the working on the disease, but PDS disease, but PDS links this to the links this to the disease due to the disease due to the fact the institution fact the institution is studying a known is studying a known protein/target that is protein/target that is being studied for being studied for that diseasethat disease

Specific disease Specific disease selection filters the selection filters the institutions for the institutions for the proteins/targets proteins/targets related to that related to that disease; further disease; further filtering by filtering by Evaluated by Evaluated by Faculty of 1000 Faculty of 1000 allows quick allows quick identification of identification of recommended recommended reading. The best reading. The best new articles are new articles are selected, evaluated selected, evaluated and rated by and rated by 10,000+ Key 10,000+ Key Opinion Leaders in Opinion Leaders in Biology & MedicineBiology & Medicine

Can also filter by Can also filter by institution type, institution type, geo-location geo-location (coming soon) and (coming soon) and link statuslink status

An Institution Report An Institution Report shows the linked shows the linked proteins/genes for proteins/genes for selected filters. Also selected filters. Also the Literature the Literature Analytics show the Analytics show the quantitative summary quantitative summary of curated articles, the of curated articles, the qualitative evaluations qualitative evaluations by the Faculty of 1000 by the Faculty of 1000 (link to evals via (link to evals via Analytic 2Analytic 2) and the ) and the number of patents. number of patents. Also links to related Also links to related diseases and diseases and investigational drugs investigational drugs are shownare shown

Analytic 1 Analytic 1 shows the shows the top authors from this top authors from this institution and drill institution and drill downs to authors downs to authors other articlesother articles

Analytic 3 Analytic 3 shows an shows an interactive graphical interactive graphical analysis of the most analysis of the most cited proteins/genes cited proteins/genes from the selected from the selected institutioninstitution

This table’s This table’s quantitative analytics quantitative analytics illustrate how this illustrate how this institution compares institution compares with it’s peer group in with it’s peer group in publishing activity for publishing activity for specific proteins. This specific proteins. This facilitates users in facilitates users in finding ‘Centers of finding ‘Centers of Excellence’ for specific Excellence’ for specific proteins of choiceproteins of choice

Grouping by Grouping by Investigational Investigational Drugs shows users Drugs shows users the institution’s the institution’s pipeline as it pipeline as it relates to specific relates to specific proteins (and/or proteins (and/or diseases). CBD’s diseases). CBD’s in-house scientists in-house scientists have linked the have linked the proteins to the proteins to the corresponding corresponding Mechanisms of Mechanisms of Action for further Action for further analytical studyanalytical study

Users can click Users can click through to a full through to a full analysis of an analysis of an institution (by institution (by default linked to default linked to Adis R&D Insights Adis R&D Insights but subscribers but subscribers can link to other can link to other pipeline databases)pipeline databases)

By selecting a By selecting a specific disease, in specific disease, in this case a High this case a High Interest Disease Interest Disease (Alzheimer, (Alzheimer, Parkinson & Parkinson & related) PDS related) PDS retrieves all the retrieves all the known known proteins/targets proteins/targets related to that related to that disease. In this disease. In this example, the example, the protein, Glutamate protein, Glutamate receptor 2 is receptor 2 is directly associated directly associated with Alzheimer’s with Alzheimer’s and disclosed as and disclosed as such by Cortex.such by Cortex.

In this example, In this example, PDS shows A&G PDS shows A&G Pharmaceutical Pharmaceutical with the Alzheimer, with the Alzheimer, Parkinson & related Parkinson & related search due to the search due to the fact that the fact that the protein/target protein/target Granulin is known Granulin is known to be associated to be associated with this selected with this selected High Interest High Interest Disease but is Disease but is NOT DISCLOSED NOT DISCLOSED by A&G as an by A&G as an Indication for Indication for Alzheimer, Alzheimer, Parkinson & related Parkinson & related diseasesdiseases

For more information please contact:For more information please contact:Jim JackettiJim Jacketti

jim.jacketti@currentbiodata.com(215) 453-3161 (direct)(215) 453-3161 (direct)