Cumulative Head Impact Exposure Predicts Later-Life Depression, files. Journal of Neurotrauma Cumulative

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    Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy,

    Executive Dysfunction, and Cognitive Impairment in Former High School and

    College Football Players

    Philip H. Montenigro, BS1,2, Michael L. Alosco, PhD1, Brett M. Martin, MS3, Daniel H. Daneshvar,

    MS1, Jesse Mez, MD, MS1,4, Christine E. Chaisson, MPH1,3,5, Christopher J. Nowinski, AB1,6, Rhoda

    Au, PhD4,7, Ann C. McKee, MD1,4,8,9, Robert C. Cantu, MD1,6,10,11, Michael D. McClean, ScD12,

    *Robert A. Stern, PhD1,2,4,10, *Yorghos Tripodis, PhD1,5.

    *These authors contributed equally to this manuscript.

    Affiliations: 1Boston University Alzheimer’s Disease and CTE Center, Boston University School of

    Medicine; 2Department of Anatomy and Neurobiology, Boston University School of Medicine; 3Data

    Coordinating Center, Boston University School of Public Health; 4Department of Neurology, Boston

    University School of Medicine; 5Department of Biostatistics, Boston University School of Public

    Health; 6Concussion Legacy Foundation; 7Framingham Heart Study, Boston University School of

    Medicine; 8Department of Pathology, Boston University School of Medicine; 9VA Boston Healthcare

    System; 10Department of Neurosurgery, Boston University School of Medicine; 11Department of

    Neurosurgery, Emerson Hospital; 12Department of Environmental Health, Boston University School of

    Public Health.

    Corresponding Author: Robert A. Stern, Ph.D., 72 E. Concord Street, Suite B7800, Boston, MA

    02118; Tel: (617) 638-5678, Fax: (617) 638-5679, Email: bobstern@bu.edu

    Abstract: 233 words Text: 5,655 words References: 114 Tables: 7 Figures: 2

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    TOC Title: Cumulative Impact Exposure in Football Predicts Neurobehavioral Impairment

    Running: Football Impacts and Later-Life Functioning

    Author Mailing and Contact Information

    P.H. Montenigro, BS, MD/PhD Candidate, Department of Anatomy and Neurobiology, Boston

    University Alzheimer’s Disease and CTE Center, 72 E. Concord Street, Suite B7800, Boston,

    MA 02118, Telephone: (617) 784-9073, Fax: (617) 638-5679, email: pmonte@bu.edu

    M.L. Alosco, PhD, Boston University Alzheimer’s Disease and CTE Center, Boston University School

    of Medicine, 72 E. Concord Street, Suite B7800, Boston, MA 02118, Telephone: (617) 414-

    8381, Fax: (617) 638-5679, email: malosco@bu.edu

    B.M. Martin, MS, Boston University School of Public Health, Data Coordinating Center, 801

    Massachusetts Avenue, 343A, Boston, MA 02118, Telephone: (617) 638-5004, Fax: (617)

    638-5066, email: brmartin@bu.edu

    D.H. Daneshvar, MS, Boston University Alzheimer’s Disease and CTE Center, Boston University

    School of Medicine, 72 E. Concord Street, Suite B7800, Boston, MA 02118, Telephone: (617)

    414-8382, Fax: (617) 638-5679, email: ddanesh@bu.edu

    J. Mez, MD, MS, Boston University Alzheimer’s Disease and CTE Center, Boston University School

    of Medicine, 72 E. Concord Street, Suite 7800, Boston, MA 02118, Telephone: (617) 638-5426

    Fax: (617) 414-1197, email: jessemez@bu.edu

    C.E. Chaisson, MPH, Data Coordinating Center and Data Management Core, 801 Massachusetts

    Avenue, 341, Boston, MA 02118, Telephone: (617) 638-5009, Fax: (617) 638-5066, email:

    chaisson@bu.edu

    C.J. Nowinski, AB, PhD Candidate Department of Behavioral Neuroscience, Boston University

    Alzheimer’s Disease and CTE Center, 72 E. Concord Street, Suite B7800, Boston, MA 02118,

    Telephone: (617) 216-9512, Fax: (617) 638-5679, email: nowinski@bu.edu

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    R. Au, PhD, Boston University School of Medicine, 72 E. Concord Street, Suite B6, Boston, MA

    20118, Telephone: (617) 638-8067, Fax: (617) 638-8086; email: rhodaau@bu.edu

    A.C. McKee, MD, Boston University Alzheimer’s Disease and CTE Center, 72 E Concord Street,

    B7800, Boston, MA 02118, Telephone: (617) 414-1188, Fax: (617) 638-5679, email:

    amckee@bu.edu

    R.C. Cantu, MA, MD, FACS, FAANS, FACSM, Emerson Hospital, John Cuming Building, 133 Old

    Rd, Suite 820, Concord, MA 01742, Telephone: (978) 369-1386, Fax: (978) 287-0047, email:

    rcantu@emersonhosp.org

    M.D. McClean, ScD, Boston University School of Public Health, Department of Environmental Health,

    715 Albany Street, Boston, MA 02118; Telephone: (617) 638-7755; email: mmcclean@bu.edu

    R.A. Stern, PhD, Corresponding author, Boston University Alzheimer’s Disease and CTE Center, 72

    E. Concord Street, Suite B7800, Boston, MA 02118; Telephone: (617) 638-5678, Fax: (617)

    638-5679, email: bobstern@bu.edu

    Y. Tripodis, PhD, Boston University School of Public Health, Department of Biostatistics, 801

    Massachusetts Avenue, Boston, MA 02118; Telephone: (617) 638-5844; Fax: (617) 638-6484,

    email: yorghos@bu.edu

    Contributor’s Statement

    Philip H. Montenigro is the primary author. He was responsible for the original design and

    conceptualization of the study and analyses, data collection, drafting of the manuscript, and

    interpretation of the data. Dr. Alosco participated in drafting and revising the manuscript. Mr. Martin

    participated in data management and analysis, and revising the manuscript. Mr. Daneshvar

    participated in initial design of the LEGEND study and revising the manuscript. Dr. Mez participated in

    revising the manuscript. Ms. Chaisson oversaw data management for this study. Mr Nowinski

    participated in obtaining funding for the study and revising the manuscript.

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