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CTSA Consortiums: WESTRN
• James F. Holmes, MD, MPH
Professor, Department of EM
UC Davis School of Medicine
CTSA Consortia
• NIH wants CTSA consortia to develop
• Strategic Goal Committee 3: enhancing Consortium-Wide Collaborations
– August 26, 2011
– https://www.ctsacentral.org/best%20practices/research%20networking
– Implement research networking tools
– Data available on people in each CTSA
– Monitor collaborations
• 15 regional consortia listed on NIH CTSA website– https://www.ctsacentral.org/regional-consortia
West Coast Emergency Services Translational Research Network
(WESTRN)• Oregon Health & Science University
• Harborview/University of Washington
• University of California at Davis
• San Francisco General Hospital/UC San Francisco
• Stanford University
• Denver Health/University of Colorado
• University of Utah
• University of California at Irvine
• University of Southern California
• University of New Mexico
WESTRN: Timeline• February 2008: 1st meeting of west coast CTSA leaders
• May 2008: 1st meeting of EM investigators– 7 sites
• Oct 2008: 2nd meeting of EM investigators– Developed process for protocol submission/approval
• May 2009: 3rd meeting and planned project
• July 2009: Protocol for 1st project
• Feb 2010: Protocol for 2nd project
• May 2012: 1st meeting of the 10 current sites
WESTRN: Grants
• Funded:– RWJ Foundation: PI Newgard
– CTSC site grants for initial project: multiple sites
– CDC R01: PI Newgard
– UC Davis CTSA site grant for 2nd project: PI Nishijima
– NIGMS F32: PI – Jody Vogel
• Submitted:– NICHD R01
– NIGMS T32
WESTRN: Projects
• 1st Project: Link prehospital trauma data with outcomes data
– 7 sites
– Multiple projects within the database
• 2nd Project: Variability of admission in patients with TBI– 8 sites
• 3rd Project: Validation of Denver trauma MOF score– Part of a F32 training grant
– 3 sites
WESTRN: Publications
• Abstracts: 12 at meetings from 2010 to 2013– ACEP, SAEM, AAST, and American Heart Association –
Resuscitation Symposium
• Manuscripts: 7– Initial project: 6 (JACS, Annals of EM, AEM, J Trauma, Prehospital
EM Care)
– 2nd project: 1 (Annals of EM)
Thematic Special Interest GroupsConsortia
• Self-developed consortia– 10 listed on NIH website: https://www.ctsacentral.org/tsig
• Developing collaborations with existing networks, societies and organizations
• Identifying specific research proposals for collaboration
• Obtaining support from NIH Institutes and Centers, research institutions, and societies
• Organizing workshops and meetings with support from NIH ICs, research institutions, and NIH conference grants
• Meeting regularly in informal settings (teleconferences and at other pre-existing meetings) to share and collaborate
ECTRC: National EM CTSA research network
• National EM CTSA research network– https://www.ctsacentral.org/committee/emergency-
care-researchers
• May 2010 first meeting – Meetings each May at SAEM
• Massive numbers of patients within network• Process, however, has been slow
Conclusion
• NIH wants consortiums among its CTSAs
• Facilitate studies needing large numbers of
subjects• Several existing consortia (see NIH website)
– Regional and thematic
• Challenges with large consortia