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CRISPR patent landscape - SAMPLE ©2014-2016 IPStudies SARL
CRISPR PATENT LANDSCAPE
January 2016
Intangibleassetsdeservecloserscru2ny
CRISPR patent landscape - SAMPLE ©2014-2016
Copyright
• Unless otherwise specified, all content included on this document, such astext, graphics, logos, bu8on icons, images, audio and video clips, digitaldownloads, data compila:ons, and so;ware, including but not limited toIPStudies surveys, is the property of IPStudies SARL and protected byinterna:onalcopyrightlaws.
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• Youmaynotre-useand/orextractpartofthiscontentoutsideofyourlegalen;ty, ins;tu;onal or corporate environment without IPStudies’s expressconsentinwri;ng.
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CRISPR patent landscape - SAMPLE ©2014-2016
Our team
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CorinneLEBUHAN,PhDICTExpertIPStrategy&Management
• FundedIPStudiesin2010tohelpSwiss&EUhigh-techSMEsdevelopandexecutetheirIPvalua:onplansusingthelatestpatentanaly:cstoolsandtrends
• 15yearsexperienceinIPstrategyandmanagement–formerVPKnowledgeManagementofNagravision-KudelskiGroup,inchargewithpatents(200families),standards,R&Dcollabora:ons,licensingandtechnicalpublica:onsporZolios
• Teachesinterna:onallicensingprac:cesandIPstrategyatIEEPI–EUHorizon2020expertonInnova:oninSMEs2013-2015
• ICTTechnologyExpertforvariouslicensingfacilitatorsandaggregatorsinFrance,GermanyandtheUS
• Universitypostgraduateinmanagementofinnova:onandintellectualproperty(UniversityofStrasbourg,2008),PhDinCommunica:onsScience(EPFL,1998),MsCinElectricalEngineering(INSARennes,1994)
• ExperiencedwithPatbase,EPO/RegisterPlus,USPTO/PAIR• Interna:onalnetworkofIPprac::onersandlicensingmanagers-
MemberLES,IEEE,AROPI,AAIEEPI
FabienPALAZZOLI,PhDLifeSciencesExpertPatentAnalysis&Landscapes
• JoinedIPStudiesin2013todeveloptheIPanaly:csofferinginlifesciences&biotechnology
• 9+yearsexperienceintechnologytransfers,patentmapping/landscapingandFTO-drivenresearchintelligencefortheFrenchpublicsectorandbiotechSMEs-formerIPanaly:cssalesmanagerforFISTSA,theCNRStechnologytransferoffice
• Author/co-authorof18scien:ficandtechnicalpublica:ons/communica:ons,aswellasonebookchapter
• Lifesciencespatentanalystforvariousbiotech/medtechSMEsinSwitzerlandandinEurope
• PhDinLifeSciences(Exploita:onofpatentinforma:oninapublicresearchlaboratory:iden:fica:onoftechnologicalnichesinbioproduc:onandgenetherapy,UniversityofTours,2011),MsCinBiotechnologyandLaw(UniversityofTours,2007)
• ExperiencedwithOrbit,Patbase,Intellixir,patentofficesdatabases
• Interna:onalnetworkofpatentinforma:onanalysts
CRISPR patent landscape - SAMPLE ©2014-2016
Table of contents
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• Methodology• OveralltrendsoftheCRISPRpatentdatabase
• Temporaldistribu:onofpatentfilings(2004-2015)• Temporaldistribu:onofpatentfilingsbytypeofapplicants(2004-2015)• Worldmapofpriorityfilings• Temporaldistribu:onofpriorityfilings(2004-2015)• Worldmapofpatentextensions• Mainpatentapplicants• Temporaldistribu:onoffilingsofapplicants• Co-filingsbetweenapplicants
• BreakdownoftheCRISPRpatentdatabase• BreakdownbyClaimcoverageofpatentfamilies
• BreakdownofthepatentporZolio• Temporaldistribu:onoffilings• Posi:oningofapplicants
• BreakdownbyComponents• BreakdownofthepatentporZolio• Temporaldistribu:onoffilings• Posi:oningoftheapplicants
• BreakdownbyChimericproteins• BreakdownofthepatentporZolio• Temporaldistribu:onoffilings• Posi:oningofapplicants
• Mainforwardcitedpatentfamilies• Appendices–licensingannouncements,affilia:onmappingofplayerspresentinthepatentlandscape
CRISPR patent landscape - SAMPLE ©2014-20165
Temporal distribuGon of patent filings by type of applicants (2004-2015)
Ø 290filingsbyins:tu:onalapplicants(59.3%),Ø 154filingsbyindustrialapplicants(31.5%),Ø 32filingsbyindividualinventors(6.5%),Ø 13co-filingsbetweenindustrialapplicantsandins:tu:onalapplicants(2.7%).Ø Theyears2014and2015arenotcompleteduetothedelayofpublica:onof18months.
489patentfamilies
CRISPR patent landscape - SAMPLE ©2014-20166
Main patent applicants/assignees (≥ 3 patent families)
Ins2tu2onalapplicants
Industrialapplicants
Ø Affiliates&subsidiarieshavebeengatheredundertheirparentcompany(DaniscowithDuPont…).Co-filingsarecounted for each co-owner: a patent applica:on co-filed between theMIT, the Harvard University and theBroadIns:tuteiscountedonceforeachco-applicant.
Ø Withinthe38mainapplicants,27areins:tu:onalapplicantsand11areindustrialapplicants.Ø ThepatentporZolioofDuPontcompriseshistoricalpatentfamiliesonCRISPRsequencesdealingwiththetyping
ofbacterialstrains,cultureswithimprovedphageresistanceandapplica:onsforpreparingfood.
CRISPR patent landscape - SAMPLE ©2014-2016
Co-filings between applicants/assignees
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Ø Theco-filingmapshowstheco-filingsbetweenapplicants,resul:ngeitherfromeitherajointR&Dprojectoralaterassignmentagreementasregisteredinpatentoffices.
Numberofpatentfamilies
inthepor9olio
Co-filing(s)betweenthetwoapplicants
CRISPR patent landscape - SAMPLE ©2014-2016
Licensor Scope Licensee Date
Toolgen
Worldwidelicense&sublicensesrightsforresearchapplica:onsincludingthedevelopmentandsaleofreagents,celllines,andanimalmodels,aswellasrightsforhighthroughputscreening,diagnos:cs,andbioproduc:on.ToolGenretainsitsrightsinbroadareasincludinghighthroughputscreening,diagnos:cs,bioproduc:on,plantbiotechnologyandgene/celltherapy.
ThermoFisherScien:fic 2015/03
DuPont
Thecross-licenseenablesCariboutodevelopandu:lizeCRISPR-Castechnologyforproductdevelopmentinmul:plefieldsincludinghumanandanimaltherapeu:cs,diagnos:cs,industrialbiotechnology,researchtools,andcertainagriculturesegments.TheDuPontlicensetoCaribouincludesrightstotheCas9-mediatedgenomeedi:ngintellectualpropertyownedbyVilniusUniversityandexclusivelylicensedtoDuPont.
CaribouBiosciences 2015/10
CaribouBiosciences
Mul:-facetedagreementincludesthecross-licensingofkeyintellectualproperty,aresearchcollabora:on,andfinancialinvestmentsbyDuPontinCaribou,adeveloperofCRISPR-Castechnologies.
DuPont 2015/10
CrisprTherapeu:cs
$105millionupfront—$75millionincash,$30millionequityinvestment-futuredevelopment,regulatoryandsalesmilestonesofupto$420millionforeachofuptosixCRISPR-Cas9-basedtreatmentsforwhichVertexhasagreedtolicenseexclusivedevelopmentrights.Royal:esonfuturesales.
Vertex 2015/10
ERSGenomicsNon-exclusivelylicensedpatentsrelatedtoCRISPR-Cas9genome-edi:ngtechnologytoRegeneronPharmaceu:calsforuseindrugdiscoveryanddevelopment
Regeneron 2015/11
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License announcements – SAMPLE PAGE (4)
CRISPR patent landscape - SAMPLE ©2014-20169
Breakdown of the CRISPR patent database
• Genomeedi:ngwithEN
• Modula:onofgeneexpression
• Otherapplica:on
• Therapeu:capplica:on
• Bioproduc:on
• Drugscreening
• Gene:callymodifiedcell
• Transgenicanimal
• Transgenicplant
Applica;ons
• Humancell/subjet
• Mammaliancell/organism
• Otheranimalcell/organism
• Plantcell/organism
• Fungi-algae-yeast
• Eukaryo:ccell/organism
• Prokaryo:ccell
• Otherorganism
• Undefinedcell/organism
Cell/Organism
• Nuclease
• ZFNuclease-ZFD
• Meganuclease
• TALENuclease-TALEP
• NA-targe:ngRNA
• CRISPR-assoc.protein
• CRISPR-Cassystem
• Otherchimericprotein
• Vector
• CRISPRsequence
‘Moleculartools’
‘CLAIMCOVERAGE’OFPATENTFAMILIES
The489patentfamilieshavebeensystema;callyreviewedandclassifiedbyourgenomicsexpert
Ø A patent family can be classified in several categories (e.g. ‘Genome Edi;ng with EN’ and ‘Therapeu;capplica;on’and‘Humancell’and‘CRISPR-Cassystem’…).
CRISPR patent landscape - SAMPLE ©2014-201610
Breakdown of the CRISPR patent database
COMPONENTS CHIMERICPROTEINS
Chimericnucleases• Undefinednuclease
• ZFNuclease
• Meganuclease
• TALENuclease
• RNA-GuidedNuclease
• Otherchimericnuclease
Otherchimericproteins
• CRISPR-associatedprotein
• mutatedCas-nickase
• dCas
• Cas9
• mutatedCas9-nickase
• dCas9
• OtherCas
• OthermutatedCas
• NA-targe:ngRNA
• gRNA
• crRNA
• tracrRNA
• psiRNA
• Nuclease
• Meganuclease
• Integrase
• Recombinase
• Repressor-Ac:vator
• Acetyltransferase
• Deacetylase
• Methyltransferase
• Demethylase
• Kinase
• Othercataly:cdomain
• Undefinedcataly:cdomain
Ø A patent family can be classified in several categories (e.g. ‘Genome Edi;ng with EN’ and ‘Therapeu;capplica;on’and‘Humancell’and‘CRISPR-Cassystem’…).
The489patentfamilieshavebeensystema;callyreviewedandclassifiedbyourgenomicsexpert
CRISPR patent landscape - SAMPLE ©2014-201611
Breakdown by Claim coverage of patent families Breakdown of the patent porXolio
EN=EngineeredNucleasesNA-targe2ngRNA=NucleicAcid-targe2ngRNA,guideRNA…
Applica2ons Cell/Organism ‘Coveredmoleculartools’
CRISPR patent landscape - SAMPLE ©2014-201612
Breakdown by Claim coverage of patent families PosiGoning of the main applicants/assignees (≥ 5 patent families)
Distribu;onofapplicantswithatleast4patentfamiliesintheirpatentporZolioOrderourfullpatentlandscapetoaccesstheapplicantnames
CRISPR patent landscape - SAMPLE ©2014-201613
Breakdown by Components PosiGoning of the main applicants/assignees (≥ 4 patent families)
Distribu;onofapplicantswithatleast4patentfamiliesintheirpatentporZolioOrderourfullpatentlandscapetoaccesstheapplicantnames
CRISPR patent landscape - SAMPLE ©2014-201614
Breakdown by Chimeric proteins PosiGoning of the main applicants/assignees (≥ 4 patent families)
Distribu;onofapplicantswithatleast4patentfamiliesintheirpatentporZolioOrderourfullpatentlandscapetoaccesstheapplicantnames
CRISPR patent landscape - SAMPLE ©2014-2016
Further analyGcs for your specific needs with the online database
• ZoomonpatentporZoliosofspecificapplicants
• Zoomonpatentsfiledinacountry/region(US,EP,CN…),withina:meperiod
• Zoomonpatentscoveringanapplica:on,adedicatedtechnology,aspecifica:onorafunc:onalsubset
• Linktoonlinepatentofficeregisterstoreviewlatestlegalstatus
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CRISPR patent landscape - SAMPLE ©2014-2016
Access to the interacGve “navigate, zoom, click and show patent” database
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CRISPR patent landscape - SAMPLE ©2014-2016
Order
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This is only a sample report with par:al data. Our fullofferincludes:• ananalysisofthepatentlandscape,covering489patentfamilies,worldwide• asynthesisofIPstrategyfindings,tovisualizekeytrendsintermsofpatentapplicants,collabora:onnetworks,compe:tortechnologyposi:oning,keyinventorsandR&Dwhitespacesoutofthelandscape• anon-lineaccesstothe489patentfamiliesset,soyoucanvisualize,navigate,focusandextractthemostrelevantpatentdataaccordingtoyourspecificneeds.
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