Course Objectives: Outcomeskbncollege.info/attachments/mscch.pdfI M.Sc I General Chemistry OCH10117 2017-18 Syllabus Total No of Hours for Teaching - Learning Instructional Hours for

KAKARAPARTI BHAVANARAYANA COLLEGE (Autonomous)

Department of Organic Chemistry ( P.G.)

Class: Semester: Title of The Paper: Paper Code: W.E.F

I M.Sc I General Chemistry OCH10117 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits

60 Hours Theory Practical

3 Hours CIA SEE

4 4 0 30 70

Course Objectives:

To provide the basic knowledge of very important concepts of the analytical chemistry

(sampling, and calibration methods, volumetric method of analysis, gravimetric analysis).

To provide the over view of the applications of these concepts in applied field to students.

Outcomes:

1. Students can learn the basic analytical and technical skills to work effectively in the various

fields of chemistry.

2. To know and understand the issues of safety regulations in the use of chemicals in their

laboratory work.

SEMESTER I

PAPER I, GENERAL CHEMISTRY, 60 Hrs (4Hrs/Week) OCH10117

UNIT-I 12 Hrs

Sampling and Errors: Sampling- Techniques of Sampling- Sampling of gases, liquids and

solids- Classification of errors - Determinate and indeterminate errors – Propagation of errors -

Minimisation of errors - Accuracy and precision - Distribution of random errors - Gaussian

distribution.

Unit – II 12 Hrs

Treatment of analytical data: Measures of central tendency - Measures of precision - Standard

deviation - Standard error of mean -student's t test - Confidence interval of mean - Testing for

significance - Comparison of two means - F-test - Criteria of rejection of an observation

Significant figures and computation rules - Control charts - Regression analysis - linear least

squares

UNIT-III 12 Hrs

Titrimetric Analysis: Classification of reactions in titrimetric analysis- Primary and secondary

standards-Neutralisation titrations-Theory of neutralisation indicators-Mixed indicators-

Neutralisation curves-Displacement titrations-Precipitation titrations-Indicators for precipitation

titrations-Volhard method-Mohr method- Theory of adsorption indicators-Oxidation reduction

titrations-Change of electrode potentials during titration of Fe(II) with Ce (IV)-Detection of end

point in redox titrations-Complexometric titrations.

UNIT- IV 12 Hrs

Methods of purification:

Distillation: Basic principles. Distillation types, continuous distillation, batch distillation,

fractional distillation, vacuum distillation and steam distillation.

Drying Techniques: Drying of Hexane, Benzene, Toluene, Xylene, Tetrahydrofuran, DMF,

DMSO, Methanol, Ethanol, Diethylether and Dioxane. Solvent extraction: Basic principles.

Different types of extraction. Selection of solvents. Avoiding emulsion formation. Basic concepts

on Soxhlet extraction. Crystallization Techniques : Different kinds of crystallization, Single

crystal generation and analysis of crystal structure.

UNIT V 12 Hrs

Computer programming: Introduction to computers and computing- Basic Structure of

computer-main memory-secondary storage memory-input/output devices, computer languages-

operating systems. Internet Usage

Introduction to MS Office- Word document preparation, power point preparation, Excel Solutions

for Chemistry.

Introduction to structural Drawing with ISIS Draw-Chem Draw

REFERENCES:

1. Vogel's text book of quantitative analysis. Addition Wesley Longmann Inc.

2. Quantitative analysis R.A Day and A.L.Underwood. Prentice Hall Pvt.Ltd.

3. Baja K K , Office Automation , MacMillan India Ltd, 1996.

4. Steve Sagman, Microsoft Office XP for Windows, Pearson Education Asia, 2002.

5. Jennifer Fulton, Microsoft Office 2000, Prentice-Hall of India, 1999.

6. Fundamentals of Analytical Chemistry - Skoog and West.

7. Basics of computers for Chemists, P.C.Jurs.

Model Question Paper

Class: I MSc Organic Chemistry Semester: I

Paper: General Chemistry Code: OCH10117

Time: 3Hrs Max. Marks: 70 M

UNIT-I

1. a) Explain the sampling of solids ,liquids and gases. (10M)

b) Explain propagation the errors. (4M)

OR

2. a) Define an error ? Explain the types of errors? How they can be minimised? (10M)

b) Explain Gaussian distribution curve? (4M)

UNIT-II

3. a) explain students t-test and f- test? (10M)

b) Explain measure of central tendency? (4M)

OR

4. a) Explain linear least square method? (8M)

b) Explain control charts? (6M)

UNIT-III

5. a) What are primary and secondary standard ? Give an example (6M)

b) Explain the theory of neutralisation indicators? (8M)

OR

6. a) Explain Volhards method Mohr method for precipitation titrations. (7M)

b) Explain Complexometric titrations with example. (7M)

UNIT-IV

7. a) Explain in detail about fractional distillation (8M)

b) Explain the generation of single crystal generation? (6M)

OR

8. a) Write a detail account on drying techniques. (10M)

b) Write a note on batch distillation. (4M)

UNIT-V

9. a) Explain block diagram of computer ? (6M)

b) Write a note on (8M)

1. Memory

2. Computer languages

OR

10. a) Application of MS Excel in analysing chemical data. (8M)

b) Write the uses of Internet? (6M)

QUESTION BANK

Class: I M.Sc Organic Chemistry Code: OCH10117

Paper: General chemistry Semester: I

Unit-I

1 Define Sampling explain the sampling of Solids, Liquids and Gaseous.

2 Define an Error? Explain the classification of error with a suitable examples.

3 Define Accuracy and Precession.

4 Explain about Gaussian distribution.

5 Explain the methods for Minimisation of errors.

6 Explain the propagation of errors.

7 Explain longpile and Alsternate shovel method and Cone and quatering method.

Unit-II

1. Explain measures of precession.

2. Explain about Students t-test and F- test

3. Write a note on Significant figures and Computation rules.

4. Write a note on Controll Charts.

5. Explain Regression analysis or Method of Linear Least squares.

6. Write a note on Confidence interval of mean.

Unit-III

1. Explain about Classification of titrations in titrimetric analysis.

2. Explain about Primary and Secondary standard solutions.

3. Explain Neutralisation titrations and Theory of Neutralisation Indicators.

4. Explain Neutralisation curves and Explain Displacement titrations.

5. Explain Precepitation titration with suitable examples.

6. Explain Volhard method ,Mohr method and theory of adsorption indicator.

7. Explain Oxidation-reduction titration with suitable examples.

8. Explain the change of electrode potentials during titration of Fe(II) with Ce(IV) detection

of end point in redox titrations.

9. Explain Complexometric titrations.

Unit-IV

1. Explain basic principle involved in Steam Distillation.

2. Explain about Continous distillation and batch distillation.

3. Explain about fractional distillation and vacuum distillation

4. Write a note on drying techniqes of ethyl alchol, Hexane, Benzene, DMSO.

5. Write the basic principle involved in solvent extract & Explain selection of solvent.

6. Explain basic concept on Soxhlet extraction.

7. What are emulsions. Write a note on avoiding emulsion formation.

8. Explain different kinds of crystallizations and Explain analysis of crystal structure.

Unit-V

1. Explain about Memory.

2. Explain the basic structure of computer.

3. Write about Computer languages.

4. Write a note on Operating systems

5. Write a note on Usage of internet.

6. Write a note on word document preparation

7. Write a note on Power point preparation and Write a note on usage of Excel

8. Write the uses of ISIS and Chem draw.




I M.Sc I Inorganic Chemistry OCH10217 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 6 30 70

Course Objectives

Students will be able to understand the geometry and structure of different molecules.

They can understand bonding nature of different compounds.

How to make reagents and its properties also can understand reaction mechanisms.

Outcomes:

To provide the basic knowledge of very important concepts of the inorganic

Chemistry(quantum mechanics, Organometallic, reagents in inorganic chemistry and

reaction mechanism of transition metal complexes.

To provide overview of the applications of the concepts in applied field to the students.

KAKARAPARTI BHAVANARAYANA COLLEGE

M.Sc ORGANIC CHEMISTRY

SEMISTER I

PAPER II, INORGANIC CHEMISTRY, 60 Hrs (4Hrs/Week) OCH10217

UNIT-I 12 Hrs

A) Introduction to Exact Quantum Mechanical Results :Schrodinger equation importance of wave

function ,Operators, Eigen values and Eigen functions, Discussion of solutions of Schrodinger‟s

equation to some model systems viz. particle in one dimensional box (applications), three

dimensional box ,Rigid rotator system and the Hydrogen atom .

B) Approximate Methods - Variation theorem, linear variation principle perturbation theory, (first

order and non degenerate). Application of variation method to the Hydrogen atom .

UNIT-II 12 Hrs

A) Metal π- complexes: preparation, structure and bonding in Nitrosyl, Dinitrogen and Dioxygen

complexes B) Chemistry of non- transition elements - Inter halogen compounds, Noble gas

compounds with special reference to clathrates. Spectral, Magnetic properties and Analytical

applications of Lanthanides and Actinides.

UNIT-III 12 Hrs

A) Concept of Hybridization, Bent‟s rule , energetics of Hybridisation, concept of Resonance.

Non-valence cohesive forces, Hydrogen bonding. B) VSEPR theory, Walsh diagrams for linear

(Be H2) and bent (H2O) molecules. Molecular Orbital theory, Symmetry of Molecular orbitals,

Molecular orbitals in triatomic (Be H2) molecules and ions (NO2-) and energy level diagrams.

UNIT-IV 12 Hrs

A) Metal –ligand bonding - Crystal Field Theory of bonding in transition metal complexes –

Splitting of d-orbitals in octahedral, tetrahedral, square planar and Trigonal bipyramidal and

Square pyramidal fields. Tetragonal distortions - Jahn Teller effect . B) Applications and

limitations of CFT. Experimental evidences for covalence in complexes .Molecular Orbital

Theory of bonding for Octahedral, tetrahedral and square planar complexes. π- bonding and MOT

- Effect of π - donor and π -acceptor ligands on Δo. Experimental evidence for π- bonding in

complexes.

UNIT-V 12 Hrs

A) Metal – ligand Equilibria in solutions - Step wise and over all formation constants .Trends in

stepwise constants (statistical effect and statistical ratio). Determination of formation constants by

Spectrophotometric method ( Job‟s method) and pH metric method( Bjerrum‟s )

B) Stability correlations - Irwing – William‟s series . Hard and soft acids and bases – Acid-base

strength and HSAB. Macro cyclic complexes - Crown ethers and Cryptates.

Reference Books

1. Inorganic Chemistry Huheey, Harper and Row.

2. Physical methods in inorganic chemistry, R.S. Drago. Affliated East-West Pvt. Ltd.

3. Concise inorganic chemistry, J. D. Lee, ELBS.

4. Modern Inorganic Chemistry, W. L. Jolly, McGrawHill.

5. Inorganic Chemistry , K. F. Purcell and J. C. Kotz Holt Saunders international.

6. Concepts and methods of inorganic chemistry, B. E. Douglas and D.H.M.C. Daniel, oxford

Press.

7. Introductory quantum mechanics , A. K. Chandra

8. Quantum Chemistry, R. K. Prasad.

9. Inorganic Chemistry, Atkins, ELBS

10. Advanced Inorganic Chemistry, Cotton and Wilkinson, Wiley Eastern

11. Quantum Chemistry, R. K. Prasad.

12. Text book of Coordination chemistry, K.Soma Sekharrao and K.N.K. Vani, Kalyani

Publishers.



Paper: Inorganic Chemistry Code: OCH10217


UNIT-I

1. a) Write down Schrödinger equation and explain the term wave function ? (6M)

b) Derive the wave function for a particle in one dimensional box ? (8M)

OR

2. a) How can you derive wave equation using operator concept ? (6M)

b) What is perturbation theory and what are its applications ? (8M)

UNIT -II

3. a) Explain the noble gas compounds with special reference to the clatharates? (8M)

b) Write a note on dioxygen complexes ? (6M)

OR

4. a) Describe the spectral and magnetic properties of Lanthanides and Actinides? (8M )

b) Explain the structure of nitrosyl complexes? (6M)

UNIT-III

5. a) Explain the salient features of VSPER theory ? (6M)

b) Draw and explain the molecular orbital energy level diagram for NO2 – ? (8M)

OR

6. a) What are Walsh diagram ? Predict the shape of H2O molecule using relevant Walsh

diagram? (8M)

b) Write an account on Bent‟s rule, energetics of hybridisation? (6M)

UNIT-IV

7. a) M.O. theory of bonding in octahedral complexes ? (8M)

b) Splitting of d-orbitals in square planar and trigonal bi pyramidal complex ? (6M)

OR

8. a) Explain Jahn- Teller effect ? (8M)

b) Experimental evidences for π- bonding in complexes (6M)

UNIT-V

9. a) Determine the formation constant by spectrophotometric method ? (8M)

b) Explain the trends in step wise constants? (6M)

OR

10. a) Explain HSAB ? (8M)

b) Explain crown ethers ? (6M)

QUESTION BANK


Paper: Inorganic Chemistry Semester: I

UNIT-1

1. Find the solution of Schrodinger wave equations to a typical rigid rotator.

2. Explain the Eigen functions and Eigen values of angular momentum.

3. Describe the application of variation method to hydrogen atom

4. How can you derive wave equation using operator concept?

5. Derive wave equation using kinetic energy operator only.

6. Write down the wave equation for rigid rotator and solve it to get eigen values.

7. Arrive at the expression for first order correction of eigen values in perturbation

method.

8. Explain the basic concepts of variation method.

9. Apply schrodinger equation for a particles in a one dimensional box and solve it for

eigen functions and eigen values.

10. Apply the variation method to obtain the eigen values of hydrogen atom.

11. Derive the wave function for a particle in one-dimensional box.

12. Derive schrodinger‟s time independent wave equation. Give physical interpretation of

wave functions?

Unit -2

1. Describe spectral and magnetic properties of lanthanides.

2. Explain the bonding in BeH2 using molecular orbitals.

3. Predict the shape of H2O molecule using Walsh diagram.

4. Describe the synthesis, structure and properties of (NPCl2)3 .

5. Write notes on interhalogen compounds.

6. Write the analytical applications of lanthanides and actinides

7. Draw Walsh diagram for linear and bent molecules.

8. Discuss the MOT for triatomic molecules.

9. Discuss about non valence cohesive forces

10. Write a note on intercalation compounds.

11. Discuss the spectral and magnetic properties of lanthanides.

12. Describe the chemistry of actinides.

13. Write an account on phosphorus-nitrogen cyclic compound.

14. Explain salient features of VSEPR theory.

Unit -3

1. What is Jahn-teller theorem? What are its consequences?

2. Discuss the experimental evidences for covalency in complexes.

3. Construct MO energy level diagram for [CoF6]-3 and explain bonding and magnetic

behaviour.

4. Explain the splitting of d orbitals in trigonal bipyramid and square pyramid crystal fields.

5. Draw and explain the crystal field splitting pattern in square pyramidal geometry.

6. Explain tetragonal distortion in an octahedral complex with a suitable examples.

7. What are the drawbacks of crystal field theory?

8. Why CN- and CO cause greater crystal field splitting and I- and Br- cause lesser crystal

field splitting? Explain .

9. Discuss the factors affecting he crystal field splitting parameter.

10. Discuss the MOT of bonding for octahedral complexes.

11. Write the exp evidences the T1 bonding in complexes and write the effect of π-donar and

π-acceptor ligands.

Unit- 4

1. Describe determination of formation constants of co-ordinations compounds by

spectrophotometric method.

2. Explain the role of HSAB method in explaining stabilities of co-ordination compounds.

3. Describe the preparation and structures of isopoly and hetsoply anions.

4. Write a note on macrocyclic complexes.

5. Write the relation between stepwise and overall formation constants? Explain these in

following reactions

i. Ag+ + 2NH3 [Ag(NH3)2]+

6. Explain Bjerrum‟s method for the determination of stability constant of a complex.

7. What are hard and soft acids? Give examples.

8. Write an account on isopoly and heteropoly acids

9. Describe the spectrophotometric method for the determination of a stability constant.

10. Discuss about Irwing-William series.

11. Write an account on macro-cyclic ligands.

Unit -5

1. Discuss ammonolysis of organic and inorganic compounds with some typical examples.

2. Describe z-value scale of kosower.

3. Describe classification and leveling effect of solvents.

4. Describe redox reactions in liquid ammonia.

5. Write a note on the classification of solvents

6. Discuss the types of chemical reactions in solvents.

7. Explain the auto ionization of a solvent.

8. Discuss the reactions of metal-ammonia solutions.

9. How non- aqueous solvents can be classified? Discuss about the levelling effect of a

solvent.

10. Explain how ligand field theory is useful in the measurement of solvent strength.

11. Write the classification of solvents?

12. Explain the types of chemical reaction in solvents?

13. Explain the ammonolysis of inorganic halides and organic compounds?

14. Write the advantages and disadvantages of using ammonia as solvent?




I M.Sc I Organic Chemistry OCH10317 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 6 30 70

Course Objectives:

The objective of learning Organic Chemistry for students is

To develop an understanding and appreciation of both structure and chemical

transformations of organic molecules.

Students will acquire basic concepts of electronic structure and be able to apply them to

solve problems from various areas of organic chemistry, including stereochemistry,

reactivity patterns and synthesis.

Improvements in learning strategies, critical-thinking, and problem-solving skills are an

expected outcome.

Out comes:

Upon completion of this course the student will be able to:

Demonstrate an intermediate ability to use effective written and/or oral communication

through the application of organic chemistry concepts and reasoning using the language of

chemistry.

Demonstrate a basic understanding of how organic chemistry impacts the natural and

technological environments.

Demonstrate an intermediate ability to use detailed data collection and analysis in order to

explore organic chemical principles, effectively communicate, and critically evaluate

results in the context of the material covered in Organic Chemistry I.

SEMISTER I

PAPER III, ORGANIC CHEMISTRY, 60 Hrs (4Hrs/Week) OCH10317

UNIT-I 12 Hrs

Nature of Bonding in Organic Molecules: Localised and Delocalized covalent bonds,

Delocalised chemical bonding conjugation, cross conjugation, hyper conjugation, Tautomerism.

Aromaticity: Concept of Aromaticity, Aromaticity of five membered, six membered rings and

fused systems.- Non benzenoid aromatic compounds-cyclopropenylcation, Cyclobutadienyl

dication, cyclopentadienyl anion-tropyllium cation and cyclooctatetraenyl dianion. Homo

aromaticity, Anti aromaticity and pseudo aromaticity.

UNIT–II 12 Hrs

Reactive Intermediates:

Generation, Structure, Stability, Detection and Reactivity of Carbocations, Carbanions, Free

radicals, Carbenes, Nitrenes and Arynes. B) Reactive Species: Generation and reactivity of

Electrophiles, Nucleophiles, Dienophiles, Ylids, Enophiles.

Unit-III 12 Hrs

Substitutions:

Aliphatic Nucleophilic Substitutions: The SN2 , SN1 , mixed SN1 and SN

2 and SN

i reactions :

Mechanism, factors effecting substitution reactions. The neighbouring group mechanism,

anchimeric assistance by σ and π bonds.

Aromatic Substitution: The SNAr, SN1 and Benzyne mechanism. Reactivity- effect of substrate

structure, leaving group and attacking nucleophile .Von Richter, Smiles, Sommelet Hauser

rearrangement.

Unit-IV 12 Hrs

Additions: Addition to carbon – carbon multiple bonds, HX, X2, stereo chemistry of addition,

formation and reaction of epoxides, syn and anti hydroxylation, hydrogenation(catalytic and Non

catalytic), Cram‟s rule, Synthetic Reactions involving C-O and C-N bond.

Unit-V 12 Hrs

Eliminations

Types of elimination (E1,E1CB,E2) reactions, mechanisms, stereochemistry and orientation,

Hofmann and Saytzeff‟s rules, Syn elimination versus anti elimination. Competitions between

elimination and substitution. Dehydration, dehydrogenation, decarboxylative elimination,

pyrolytic elimination, molecular rearrangement during elimination.

Reference Books :

1.Advanced organic chemistry, Reaction, mechanism and structure, Jerry March,

John Wiley.

2. Advanced organic chemistry, F.A.Carey and R.J.Sundberg, Springer , New York.

3. A guide book to Mechanism in organic chemistry, Peter Sykes, Longman.

4. Organic chemistry, I.L.Finar, Vol. I & II, Fifth ed. ELBS, 1975.

5. Organic chemistry, Hendrickson, Cram and Hammond (McGraw – Hill).

6. Modern organic Reactions, H.O.House, Benjamin.

7. Structure and mechanism in organic chemistry, C.K.Ingold, Cornell University Press.

8. Principles of organic synthesis, R.O.C.Norman and J.M.Coxon, Blakie Academic &

Professional.

9. Reaction Mechanism in OganicCemistry, S.M.Mukherji andS.P.Singh, Macmillan.

10. Basic Principles of Organic Chemistry by J. B. Roberts and M. Caserio.



Paper: Organic Chemistry Code: OCH10317


UNIT-I

1. a) Define localised and delocalized covalent bonds? (6M)

b) Explain cross and hyper conjugation ? (8M)

OR

2. a) Explain anti aromaticity and aromaticity of five membered compounds? (6M)

b) Explain non benzenoid aromatic compounds? ( 8M)

UNIT-II

3. a) Explain generation ,structure ,stability , detection and reactivity of carbonium ion?

(8M)

b) Explain ylids and carbenes? (6M)

OR

4. a) Explain generation and reactivity of nitrenes? (6M)

b) Explain about arynes and nucleophiles? (8M)

UNIT-III

5. a) Explain SN1, SN2 mechanisms? (8M)

b) Smiles rearrangement (6M)

OR

6. a) Explain benzyne mechanism and Von-Richter rearrangements? (8M)

b) Explain neighbouring group participation? (6M)

UNIT-IV

7. a) Explain hydroxylation? (8M)

b)Explain the formation and reaction of epoxides? (6M)

OR

8. a) Explain hydrogenation? (8M)

b) Explain Crams rule? (6M)

UNIT-V

9. a ) Explain E1CB (8M)

b) Differentiate syn and anti elimination? (6M)

OR

10. a) Explain Saytzeff‟s rule? (6M)

b) Pyrolytic Elimination? (8M)

QUESTION BANK


Paper: Organic Chemistry Semester: I

Unit-I

1. What is aromaticity what are the various characteristics which differentiate aromatic

compounds from aliphatic compounds?

2. Explain the term tautomerism, explain about conjugation and Hyper Conjugation,

Inductive effect and Huckel Rules?

3. Define aromatic, anti aromatic and Non aromatic compounds with suitable examples?

4. Explain the aromaticity of six membered rings and fused rings?

5. Explain the aromaticity exhibited by Azulenes and Feereocenes, Annulenes?

6. Write a short note on Homo aromaticity and Pseudo Aromaticity?

7. Describe in detail the aromaticity of benzonoid and Non bezonoid compounds with

suitable examples?

8. Explain Conjugation and cross Conjugation?

9. Explain delocalized Covalent Bonds with Examples?

10. Explain the Aromaticity of Cyclopropenyl cation and Tropylium cation?

Unit-II

1. Write about generation and reactivity of (i) enophilies (ii) dienophiles?

2. Discuss the generation structure stability and reactivity of carbocation?

3. Explain the Benzyne mechanisim?

4. Discuss the structure stability detection and reactivity of Free Radicals?

5. What are carbenes, Cabanions? Explain the reactivity of different type carbebes,

Carbanions?

6. Write a note on generation, reactivity and mechanism of electrophiles?

7. Explain briefly reactivity of the following (i) Nucleophiles (ii) Ylids?

8. Explain reactivity of Areynes, Nitrenes, Carbenes?

Unit-III

1. Explain about Neihhbouring participation, Anchimeric assistance SNi ?

2. Explain about Aromatic Electrophilic substitution and aromatic Nucleophilic substitution?

3. Explain about SN2 mechanism with examples?

4. Explain about (i) SN Ar (ii) Benzyne Mechanism?

5. What are the factors Aromatic Nucleophilic substitution reactions?

6. What are the factors Aromatic Nuclephilic substitutjion reactions?

7. What are the major differences between aliphatic nucleophilic substitution and aromatic

Nucleophilic substitution give and examples?

8. Descuss the mechanism of Unimolecular and Bimolecular Aromatic Nucleophilic

substitution?

Unit-IV

1. Write a short note Syn and Anti Hydroxylation, Cram‟s Rule?

2. Explain the molecular rearrangement during elimination?

3. Write in detail about Pyrolytic elimination, Hofffmannn Elimination?

4. Explain the following competition between Elimination and Substitution, Catalytic

Hydrogention?

5. Write the stereo chemistry of Addition to C-C multiple bonds with HX?

6. Explain in detail about Non catalytic Hydrogenation with Examples?

Unit-V

1. Explain stereo chemistry of products in E2 and E1 reaction with Suitable examples?

2. Write a short note on Saytzef Rule, E1CB Mechanism?

3. Write a note on competition between elimination and substitution?

4. Write a note on pyrolytic elimination?

5. Molecular rearrangement during elimination?


Department of Organic Chemistry( P.G.)


I M.Sc I Physical Chemistry OCH10417 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 6 30 70

Course Objectives:

To provide a basic understanding of the core area of physical chemistry, based around the theme

of systems, states and processes. Topics covered are chemical thermodynamics and equilibria, and

kinetics.

A good understanding of physical chemistry is important to students intending to complete a

major or minor study in chemistry, and it lies at the borderline with engineering.

Demonstrate a basic understanding of organic chemistry principles to effectively solve problems

encountered in everyday life and in science using appropriate computational

Outcomes

On successful completion of the course students will be able to:

Developed an understanding of the breadth and concepts of physical chemistry;

Developed an understanding of the role of the chemist and chemical engineer in tasks

employing physical chemistry

An understanding of methods employed for problem solving in physical chemistry;

Experience in some scientific methods employed in basic and applied physical chemistry

Developed skills in procedures and instrumental methods applied in analytical and

practical tasks of physical chemistry.

Developed skills in the scientific method of planning, developing, conducting, reviewing

and reporting experiments.



SEMISTER I

PAPER IV, PHYSICAL CHEMISTRY, 60 Hrs (4Hrs/Week) OCH10417

UNIT-I 12 Hours

Thermodynamics–I

Classical Thermodynamics - Brief review of first and second laws of thermodynamics - Entropy

change in reversible and irreversible processes - Entropy of mixing of ideal gases - Free energy

functions - Gibbs-Helmholtz equation - Free energy changes in chemical reactions: Van't Hoff

reaction isotherm - Van't Hoff equation - Clausius Clapeyron equation - partial molar quantities -

Chemical potential - Gibbs- Duhem equation - partial molar volume - determination of partial

molar quantities - Fugacity - Determination of fugacity.

UNIT – II 12 Hours

Surface phenomena and phase equilibria- Surface tension - capillary action - pressure difference-

across curved surface (young - Laplace equation) - Vapour pressure of small droplets (Kelvin

equation) -Gibbs-Adsorption equation - BET equation - Estimation of surface area

Surface active agents - Classification of surface active agents - Micellisation - critical Micelle

concentration (CMC) - factors affecting the CMC of surfactants, micro emulsions - reverse

micelles.

UNIT – III 12 Hours

Electrochemistry – I - Electrochemical cells - Measurement of EMF - Nernst equation –

Equilibrium constant from EMF Data - pH and EMF data - concentration cells with and without

transference – Liquid junction potential and its determination – Activity, activity and mean

activity coefficients - Determination of solubility product from EMF measurements.

Conductance and Effect of dilution on equivalent conductance - Anomalous behaviour of strong

electrolytes, Debye Huckel-Onsagar equation - verification and limitations - Debye Huckel

limiting law and its verification, conductometric titrations..

UNIT – IV 12 Hours

Chemical kinetics- Methods of deriving rate laws - complex reactions - Rate expressions for

opposing, parallel and consecutive reactions involving unimolecular steps. Theories of reaction

rates -collision theory - Steric factor - Activated complex theory - Unimolecular reactions -

Lindemann theory

Reactions in solutions - Influence of solvent - Primary and secondary salt effects - Chain reactions

- Rate laws of H2-Br2, photochemical reaction of H2-Cl2. Decomposition of acetaldehyde and

ethane - Rice-Hertz feld mechanism.

UNIT-V 12 Hours

Radio Chemistry:

Introduction to Radio activity, properties of alpha, beta and gamma rays, theory of radio active

disintegration, Geiger Nuttal rule, Radio active equilibrium, Radio active and non Radio active

isotopes, group displacement law, Analysis of isotopes-Astons mass spectrograph, Dumpster‟s

method, separation of isotopes-diffusion method, evaporation and distillation method, chemical

exchange method, Applications of isotopes in chemical analysis , exchange reaction, Reaction

mechanism and carbon dating.

REFERENCES:

1. Physical Chemistry P.W. Atkins, ELBS

2. Chemical Kinetics - K.J. Laidler, McGraw Hill Pub.

3. Text Book of Physical Chemistry. Samuel Glasstone, Mcmillan Pub.

4. Physical Chemistry, G.W.Castellan. Narosa Publishing House

5. Thermodynamic for Chemists. Samuel Glasstone

6. Electrochemistry, Samuel Glasstone, Affiliated East West

7. Physical Chemistty, W.J. Moore, Prentice Hall

8. Atomic structure and chemical bond. Manas chanda. Tata McGraw Hill Company Limited.

9. Fundamentals of Molecular spectroscopy: by C.N. Banwell

10. Molecular spectroscopy by B.K.Sharma

11. Vibrational Spectroscopy by D.N.Sathyanarayana New Age Int. Pub.

12. Spectroscopy by Aruldas.



Paper: Physical Chemistry Code: OCH10417


UNIT-I

1. a) Derive Maxwell Partial relations? (8M)

b) Derive Calsius clyperon equation? (6M)

OR

2. a) Derive the Gibs Duhem Equation? (8M)

b) Discuss First and Second law thermody (6M)

UNIT-II

3 a) Explain Critical Micelle concentration and the factors effecting CMC of surfactants?

(8M)

b) Derive Kelvin Equation. . (6M)

OR

4. a) Explain the classification of surface active agents? (8M)

b) Derive Gibbs adsorption equation?

. (6M)

UNIT-III

5. a) How is solubility product determined form EMF measurements? (8M)

b) Explain different types of Conductometric titrations? (6M)

OR

6. a) State and explain Debye Huckle Onsagar Equation what are its limitations? (8M)

b) Explain how the PH

of a solution is determind from EMF method? (6M)

UNIT-IV

7. a) Write the collision theory of reaction rates? (8M)

b) Derive rate law for the photochemical decomposition of Acetaldehyde? (6M)

OR

8. a) Derive rate expression for consecutive reactions involving unimolecular steps? (8M)

b) Discuss the primary and secondary salt effects on reactions in solutions? (6M)

UNIT-V

9. a) Explain radio active equilibrium with suitable equations? (8M)

b) Write the applications of radio isotopes in reaction mechanism? (6M)

OR

10. a) Explain the principle and functioning of Astons Mass Spectrograph? (8M)

b) Write a note on Artificial Radio activity? (6M)

QUESTION BANK


Paper: Physical chemistry Semester: I

Unit-I

1. Derive the Maxwell Thermodynamic relations?

2. Derive the Gibs Duhem Equation?

3. What is Fugacity? Give its physical significance. Describe the different methods

determination fugacity?

4. Derive Maxwell Partial relations?

5. Derive Clausius clayperon equation?

6. What is the partial molar Volume? Explain how the Partial molar volume is determined by

Density measurements?

7. Discuss First and Second law thermodynamics?

Unit-II

1. Explain Critical Micelle concentration and the factors effecting CMC of surfactants?

2. Derive Kelvin Equation. What is the minimum size of water droplets such that the vapour

pressure does not differ by more than one percent from the bulk value?

3. Explain the classification of surface active agents?

4. Derive Gibbs adsorption equation?

5. Write a short note on reverse Micelle and their application?

6. Explain Hydrophobic interactions?

7. Derive BET equation.

Unit-III

a) How is solubility product determined form EMF measurements?

b) What is activity? How is activity coefficient determined from EMF?

c) Explain different types of Conductometric titrations?

d) What is the Debye Huckle limiting law? How it verified?

e) What is the effect of dilution on equivalent conductance of electrolytes?

f) What is liquid junction potential? How is it determined?

g) Explain Bjeerum treatment of Electrolytes?

h) State and explain Debye Huckle Onsagar equation what are its limitations?

i) Explain how the PH

of a solution is determined from EMF method?

Unit-IV

c) Write the collision theory of reaction rates?

d) Derive rate law for the photochemical decomposition of Acetaldehyde?

e) Derive rate expression for consecutive reactions involving unimolecular steps?

f) Discuss the primary and secondary salt effects on reactions in solutions?

g) What are potential energy surfaces? Explain how thermodynamic parameters of

chemical reactions are evaluated by kinetic studies?

h) Deduce linear free energy relationship. Discuss the cases in which its correlation is

poor?

i) Explain the influence of solvent on rates of chemical reactions?

j) Discuss Lindmens Theory of Unimolecular reactions and explain its limitations?

k) Discuss the kinetics of Opposing reactions?

l) Write Rice-Hertzfeld mechanism for the decomposition of acetaldehyde obtain an

expression for the formation of methane?

m) Explain Hammet equation and discuss its limitations?

n) Discuss the law of decomposition of Actaldehyde?

o) Discuss structure – reactivity relationships using Hamet – Taft Equation?

Unit-V

p) Write the properties of Alpha, Beta and Gamma radiations?

q) Explain the principle and applications of radio active dating?

r) Explain radio active equilibrium with suitable equations?

s) Write the applications of radio isotopes in reaction mechanism?

t) Explain the principle and functioning of Astons Mass Spectrograph?

u) Write a note on Artificial Radio activity?




I M.Sc II General Chemistry OCH20117 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Objective:

To provide the basic knowledge of very important concepts of the analytical chemistry

(sampling, and calibration methods, volumetric method of analysis, gravimetric analysis).

To provide the over view of the applications of these concepts in applied field to students.

Outcomes:

3. Students can learn the basic analytical and technical skills to work effectively in the various

fields of chemistry.

4. To know and understand the issues of safety regulations in the use of chemicals in their

laboratory work.

SEMISTER II

PAPER I, GENERAL CHEMISTRY, 60 Hrs (4Hrs/Week) OCH20117

UNIT-1 12 Hours

Symmetry and Group theory in Chemistry - Symmetry elements, symmetry operation,

definition of group, sub group, relation between order of a finite group and its sub group. Point

symmetry group. Schonfiles symbols, representation of groups by Matrices (representation for the

Cn, Cnv, Cnh, Dn etc. groups to be worked out, explicitely). Character of a representation. The

great orthogonality theorem (without proof) and its importance. Character tables and their use.

Application of group theory in IR and Raman spectroscopy.

UNIT – II 12 Hours

Spectrophotometry: Introduction, fundamental laws of photometry, the electromagnetic

spectrum and spectrochemical methods, UV/Visible instrumentation, absorption spectra, Beer-

Lambert‟s Law, deviation from Beer‟s Law.

Photometric Titrations: Titration curves and applications to quantitative analysis,

spectrophotometric determination of Pka

value of an indicator and Simultaneous

Spectrophotometric determinations.

UNIT-III 12 Hours

Motion of molecules- Degrees of freedom –Energy association with the degrees of freedom Types

of spectra.

Microwave spectroscopy. Classification of molecules, rigid rotor model, effect of isotopic

substitution on the transition frequencies, Intensities non-rigid rotator-Microwave spectra of

polyatomic molecules.

UNIT – IV 12Hours

Infared Spectroscopy -Harmonic oscillator, vibrational energies of diatomic molecules, zero

point energy, force constant and bond strengths, anhoremonicity Morse potential energy diagram.

Vibration – rotation spectroscopy. PQR branches, Born oppenheimer approximation, Break down

of Born Oppenheimer approximation, selection rules- normal modes of vibration, group

frequencies- overtones- hot bands- application of IR spectra to

polyatomic-molecules.

UNIT-V 12Hours

Raman spectroscopy- Classical and quantum theories of Raman effects, pure rotational,

vibrational and Vibrational – rotational Raman spectra, selection rules, mutual exclusion

principle.

Electronic Spectroscopy-Electronic Spectra of diatomic molecules, vibrational structure of an

electronic transition, classification of bands, and rotational fine structure of electronic vibrational

transition - Electronic Spectra of Polyatomic Molecules – Instrumentation–Applications.

SUGGESTED BOOKS:

1. Fundamentals of Molecular spectroscopy: by C.N.Banwell

2. Introductory Group Theory for Chemists – George Davidson

3. Group theory for chemistry – A.K.Bhattacharya

4. Molecular spectroscopy by B.K.Sharma

5. Vibrational Spectroscopy by D.N. Sathyanarayana New Age Int. Pub.

6. Spectroscopy by Aruldas.

7. Chemical Analysis by H.A.Laitinan and W.E.Harris, McGraw Hill.

8. Separation Techniques by M. N. Sastri, Himalaya Publishing House (HPH), Mumbai.


Class: I MSc Organic Chemistry Semester: II

Paper: General Chemistry Code: OCH20117


UNIT-I 1. a) Write a note on elements of symmetry and symmetric operations. (10M)

b) State and explain Great Orthogonality Theorem. (4M)

OR

2. a) Derive C2V Character table. (10M)

b) Show that C2V is an abelien group. (4M)

UNIT-II

3. a) Explain the instrumentation of UV spectrophotometer. (10M)

b) State and explain Beers law and write its deviations. (4M)

OR

4. a) Write a note on photometric titrations and write its applications in quantitative Analysis

(8M)

b) Explain the spectrophotometric determination of pK value of and indicator. (6M)

UNIT-III

5. a) Write a note on degrees of freedom and energy associated with degrees of

freedom. (6M)

b) Describe the rotational spectra of a diatomic molecule as rigid rotor. (8M)

OR

6. a) Explain the effect of isotopic substitution on rotational spectra of a diatomic molecule.

(7M)

b) . Explain the microwave spectra of poly atomic molecule. (7M)

UNIT-IV

7. a) Explain the vibrational spectra of an anharmonic oscillator. (8M)

b) Wrie a note on Born Oppenheimer approximation and write its brake down (6M)

OR

8. a) Explain spectra of Vibration- rotation spectroscopy. (10M)

b) Write a note on overtone and hot bands. (4M)

UNIT-V

9. a) Write the classical and quantum theories of Raman effect (6M)

b) Explain mutual exclusion principle. (8M)

OR

10. a) Explain mutual exclusion principle. (8M)

b) Explain the electronic spectra of di atomic molecule. (6M)

QUESTION BANK

Class: II M.Sc Organic Chemistry Code: OCH20117

Paper: General chemistry Semester: II

Unit-I

1. Write a note on elements of symmetry and symmetric operations.

2. Define a Group and Sub group.

3. Write the relation between order of a group and sub group.

4. Define a point group and describe the procedure to determine a point group of a molecule.

5. Write the matrix representation of a C2V point group.

6. State and explain Great Orthogonality Theorem.

7. Derive C2V Character table.

8. Write the applications of a Group theory to IR and Raman spectroscopy.

9. Write the anatomy of Character table.

10. Show that C2V is an abelien group.

Unit-II

1. Write the fundamental laws of photometry.

2. Explain the instrumentation of UV spectrophotometer.

3. State and explain Beers law and write its deviations.

4. Write a note on photometric titrations and write its applications in quantitative

Analysis

5. Explain the spectrophotometric determination of pK value of and indicator.

6. Write a note on simultaneous spectrophotometric determinations.

Unit-III

1. Write a note on degrees of freedom and energy associated with degrees of

freedom.

2. Write the classification of spectra

3. Describe the rotational spectra of a diatomic molecule as rigid rotor.

4. Explain the effect of isotopic substitution on rotational spectra of a diatomic molecule

5. Describe the rotational spectra of a non rigid rotor.

6. Explain the microwave spectra of poly atomic molecule.

Unit-IV

1. Explain the vibrational spectra of an harmonic oscillator.

2. Explain the vibrational spectra of an anharmonic oscillator.

3. Explain spectra of Vibration- rotation spectroscopy.

4. Write a note on PQR branches

5. Write a note on molecular vibrations.

6. Wrie a note on Born Oppenheimer approximation and write its brake down

7. Write a note on overtone and hot bands.

8. Write the applications of IR spectra to poly atomic molecule.

Unit-V

1. Write the classical and quantum theories of Raman effect

2. Explain pure rotational and vibrational Raman spectra.

3. Explain mutual exclusion principle.

4. Explain the electronic spectra of di atomic molecule.

5. Write the electronic spectra of polyatomic molecules.




I M.Sc II Inorganic Chemistry OCH20217 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Learning Outcomes:

Students will be able to understand the geometry and structure of different molecules.

They can understand bonding nature of different compounds.

How to make reagents and its properties also can understand reaction mechanisms.

Objectives

To provide the basic knowledge of very important concepts of the inorganic

Chemistry(quantum mechanics, organo metallic, reagents in inorganic chemistry and

reaction mechanism of transition metal complexes.

To provide overview of the applications of the concepts in applied field to the students.

PAPER II, INORGANIC CHEMISTRY, 60 Hrs (4Hrs/Week) OCH20217

UNIT-I 12 Hours

Nonmetal cages and metal clusters:

Structure and bonding in phosphorous-oxygen, phosphorous-sulphur cages; structure and bonding

in higher boranes with (special reference to B12 icosahedra). Carboranes, metallo boranes,

metallo carboranes.

Metal clusters: Classification- LNCs and HNCs , Isoelectronic and Isolobal relationships ,

electron counting rules: Wade‟s and Lauher‟s rules. M-M multiple bonding; preparation,

structrure and bonding in dinuclear [Re2Cl8]2-ion, trinuclear [Re3Cl9], tetra nuclear W4(OR)W16,

hexa nuclear [Mo6Cl8]4+

and [Nb6Cl12]2, Applications of clusters

UNIT-II 12 Hours

Organ metallic chemistry of transition metals:

Classification and electron counting rules, hapticity, synthesis, structure and bonding of Olefinic

complexes, Acetylene complexes, ferrocene, dibenzene chromium, cyclo heptatriene and

tropylium complexes of transition metals.

Reactions of organometallic compounds - oxidative addition reductive elimination, insertion and

elimination. Applications of organometallic compounds-Catalytic hydrogenation, Hydro

formylation, Zeigler- Natta catalyst for polymerization of olefins.

UNIT III 12 Hours

Reaction mechanism of transition metal complexes:

Kinetics of octahedral substitution, acid hydrolysis, base hydrolysis -conjugate base (CB)

mechanism. Direct and indirect evidences in favour of CB mechanism. Anation reactions.

Reactions without metal-ligand bond cleavage. Factors affecting the substitution reactions in

octahedral complexes.

Trans effect on substitution reactions in square planar complexes. Mechanism of redox reactions,

outer sphere mechanism, cross reactions and Marcus –Hush equation, inner sphere mechanism,

complementary and non – complementary reactions.

UNIT IV 12 Hours

Term symbols and their derivation. Microstates, Hunds rules to predict ground terms and ground

states. List of ground energy and higher energy terms from d1

to d9 configurations Electronic

spectra of transition metal complexes Electronic configurations and Spectroscopic terms.

Selection rules, Slator–Condon parameters, Racah parameters, Term separation energies for dn

configurations, Orgel diagrams. TanabeSugano diagrams for d1 to d

9 configurations. Calculations

of Dq, B and β parameters. Charge transfer spectra.

UNIT-V 12 Hours

Bio-inorganic chemistry and Magnetic properties of complexes

storage and transport of dioxygen by Haemoglobin and Myoglobin. Vitamin B12 and its

importance. Magnetic properties of transition metal complexes Types of magnetism, factors

affecting Para magnetism, anomalous magnetic moments - Orbital and spin contribution , spin -

orbit coupling and magnetic moments. Chiro optical properties, Cotton effect and Faraday effect.

References:

1. Inorganic Chemistry ,Huheey. Harper and Row.

2. Concise inorganic chemistry ,J. D. Lee, ELBS.

3. Inorganic chemistry ,K.F. Purcell and J.C. Kotz, Holt Saunders international

4. Organometallic chemistry ,R.C. Mehrotra and A. Singh. New Age International.

5. Advanced Inorganic Chemistry ,Cotton and Wilkinson, Wiley Eastern

6. Inorganic reaction mechanism ,Basolo and Pearson, Wiley Eastern

7. Bioinorganic Chemistry ,K. Hussan Reddy

8. Biological Aspects of inorganic chemistry , A. W. Addiso, W. R. Cullen, D. Dorphin and G.

J.James. Weliey Interscience.

9. Photochemistry of coordination compounds, V.Balzaniand V.Carassiti. Academic Press.

10. Text book of Coordination chemistry by K.SomaSekharrao and K.N.K. vani, Kalyani

Publishers.



Paper: Inorganic Chemistry Code: OCH20217


UNIT-I 1. a) What are Wades and Lauher rule ? How are they helpful in counting electrons in

metal cluster ? (6M)

b) Describe the structure and bonding in higher boranes ? (8M)

OR

2. a) Discuss the preparation ,structure ,bonding and magnetic property of Re2Cl8 2-ion? (8M)

b) Write a short note on phosphorous and oxygen cages? (6M)

UNIT-II 3. a) Discuss the significance of oxidative addition and reductive elimination in the

catalytic applications of organometallic compounds? (8M)

b) Write a short note on Zeigler-natta catalyst polymerization? (6M)

OR

4. a) Discuss the structure and bonding in ferrocene and explain its bonding using M.O. theory?

(6M)

b) Write a note on catalytic hydrogenation and hydroformylation ? (8M)

UNIT-III 5. a) Explain acid hydrolysis? (8M)

b) Explain the reactions without metal ligand bond cleavage? (6M)

OR

6. a) Complimentary and non- complementary reactions (6M)

b) Write then mechanism of redox reactions? (8M)

UNIT-IV

7. a) Charge transfer spectra (8M)

b) Explain Slator Condon parameters ? (6M)

OR

8. a) Draw T.S. diagram for d5

configuration ? (8M)

b) Explain microstate? (6M)

UNIT-V

9. a) Write a note on myoglobin? (6M)

b) What is paramagnetism and what are the factors affecting paramagnetism? (8M) OR

10. a) Write a note on cotton effect and faraday effect? (6M)

b) Write the structure and function of vitamin B12? (8M)

QUESTION BANK


Paper: Inorganic Chemistry Semester: II

UNIT-1 1) Describe the bonding and structure in higher boranes.

2) Write a note on metallo-boranes.

3) Describe iso-electronic and isolobal relationships with suitable exampes.

4) Discuss the structure and bonding in [Re2cl8]-2ion.

5) Explain the preparation and structure of metallocarboranes.

6) Write a note on phosphorous-oxygen cages.

7) Describe the wades and lauher‟s rules. Calulate electron count in typical cases.

UNIT-2 1) Describe the structure of ferrocene and explain it‟s bonding using MO theory.

2) Explain the bonding in dibenzene chromium.

3) Discuss the significance of oxidation addition and reductive elimination and the

catalytic applications of organometallic compounds.

4) Discuss the mechanicsm for the ziegler – Natta catalysis.

5) Define electron counting rules and hapticity.

6) Write the structure and bonding of acetylene complexes.

UNIT-3 1) Describe the mechanism of base hydrolysis in octahedral complexes.

2) Explain marcus-hush equation.

3) Define and explain trans effect.

4) Write a note on anation reactions.

5) Explain the outer sphere mechanism of redox reactions.

6) Write the difference between complementary and non-complementary reactions.

7) Discuss the direct and indirect evidences in favour of conjugat base mechanism.

8) Write a note on reactions without metal-ligand bond cleavage.

9) Explain the mechanism of electron transfer reactions.

UNIT-4 1) Define and explain racah parameters. Describe their calculation.

2) Describe charge transfer spectra.

3) Write a note on slater-condon parameters.

4) Define microstates and discuss how hunds rules to predict ground terms and ground

States.

5) Discuss the calculation of Dq and β parameters.

6) Draw the orgel diagram and tanabe sugano diagrams for d2 and d9 configuration.

UNIT-5

1) Discuss the transport of dioxygen by myoglobin and write its importance.

2) Define and explain cotton and faraday effects.

3) Describe the spin orbit coupling and magnetic moments of complexes.

4) Describe the factors affecting para magnetism.

5) Writs about chiro optical properties of transition metal complexes.

6) Write the structure and function of vitamin B12.




I M.Sc II Organic Chemistry OCH20317 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Out comes:

Upon completion of this course the student will be able to:

Demonstrate an intermediate ability to use effective written and/or oral communication

through the application of organic chemistry concepts and reasoning using the language of

chemistry.

Demonstrate a basic understanding of how organic chemistry impacts the natural and

technological environments.

Demonstrate an intermediate ability to use detailed data collection and analysis in order to

explore organic chemical principles, effectively communicate, and critically evaluate

results in the context of the material covered in Organic Chemistry I.

Objectives:

The objective of learning Organic Chemistry for students is

To develop an understanding and appreciation of both structure and chemical

transformations of organic molecules.





expected outcome.

PAPER III, ORGANIC CHEMISTRY, 60 Hrs (4Hrs/Weak) OCH20317

UNIT – I

Stereochemistry 12 Hours

Concept of Chirality: Recognition of symmetry elements and chiral structures (one and more than

one chiral centers); D-L and R–S nomenclature, diastereo isomerism; Inter-conversion of Fischer,

Newman and Sawhorse projections. Threo and Erythro isomers, - stereo specific and stereo

selective synthesis. Asymmetric synthesis. - Optical activity in the absence of chiral carbon

(biphenyls, allenes and spiranes).

Racemic Modifications – Nature and formation of racemic modifications – by mixing, by

synthesis, by racemization, by chemical transformations, Geometrical isomerism- methods of

resolution – E, Z- nomenclature – physical and chemical methods of determining the

configuration of geometrical isomers. Stereochemistry of compounds containing nitrogen, sulphur

and phosphorous.

UNIT–II 12 Hours

Conformational analysis:

Conformations of acyclic molecules – alkanes and substituted alkanes –compounds having

intramolecular hydrogen bonding, conformations around C-C and carbon hetero atom bonds

having C–O & C–N. Conformations of monocyclic compounds – cyclohexane- chair, boat and

twist boat cyclohexanes, energy profile diagrams –Mono and di- substituted cyclohexanes.

Effect of conformation on reactivity in mono and di- substituted cyclohexane derivatives.

Elementary treatment of fused and bridged ring systems – Decalines and Bornanes.

UNIT–III 12 Hours

Named reactions: Aldol, Claisen, Perkin, Stobbe, Knovenagel, Darzen, Reformatsky, Benzoin

and Dieckmann condensations. Grignard, Cannizzaro, Wittig. Wittig-Horner reactions, Favorskii

rearrangement, Mannich, Michael, Reimer-Tiemann Reaction.

UNIT–IV 12 Hours

Protecting groups:

Theory and importance of functional group protection and deprotection in organic synthesis:-

Protecting agents for the protection of functional groups: Hydroxyl group, Amino group,

Carbonyl group and Carboxylic acid group.

Carbon-carbon multiple bonds; chemo- and regioselective protection and deprotection.

Illustration of protection and deprotection in organic synthesis.

UNIT-V 12 Hours

Heterocyclic Chemistry:

Structure, Synthesis and reactivity of the following systems

Pyrazole, Imidazole, Oxazole, Iso-Oxazole, Thiazole, Isothiazole

Pyrazine, Pyrimidine, pyridazine, Indole, Quinoline, Isoquinoline

References:

1. Advanced organic chemistry –Reaction, mechanism and structure, Jerry March,

John Wiley.

2. A guide book to Mechanism in organic chemistry, Peter Sykes, Longman.

3. Organic chemistry, I.L.Finar, Vol. I & II, Fifth ed. ELBS, 1975.

4. Stereo Chemistry of carbon compounds – E.L. Eliel.

5. Principles of organic synthesis, R.O.C.Norman and J.M.Coxon, Blakie Academic &

Professional.

6. Reaction Mechanism in organic chemistry, S.M.Mukherji and S.P.Singh, Macmillan.

7. Methods and reagents for Green chemistry, Pietro Tundo, Alvise Perosa, Fulvio Zecchini;

Wiley inter science, John wiley & sons Inc.,

8. Protecting Groups in Organic Chemistry, P.J.Kocienski , Georg thiemevers,

9. Protecting Groups in Organic Chemistry, T.W.Greene, Wiley Interscience Publishers, New

York.

10. Hetero chemistry, T.L. Gilchriot, Longman science and tech

11. An introduction to the Chemistry of Heterocyclic Compounds, R.M.Acheson, Interscience

Publishers, New York

12. Heterocyclic chemistry by Jai Jack Lie, Springer publications.



Paper: Organic Chemistry Code: OCH20317


UNIT-I

1. a) Explain stereospecific , stereo selective synthesis and asymmetric synthesis? (6M)

b) Explain the optical activity in the absence of chiral carbon ? (8M)

OR

2. a) Explain the nature and formation of racemic modification ? (6M)

b) Explain the stereochemistry of compounds containing nitrogen and sulphur ? (8M)

UNIT-II

3. a) Explain the conformations of the compounds containing intramolecular hydrogen bonding.

(8M)

b) Conformations of the compounds containing carbon hetero atom bonds ? (6M)

OR

4. a) Explain the effect of conformation on reactivity in mono and di substituted

cyclohexane derivatives? (8M)

b) Explain decalines and bornanes? (6M)

UNIT-III

5 .a) Stobbe and Witting –Horner reaction (6M)

b) Mannich and Cannizzaro reaction. (8M)

OR

6. a) Riemer – Tiemann reaction (6M)

b) Darzin and Perkin reaction (8M)

UNIT-IV

7. a) Explain the proctecting and deprotecting of hydroxyl group? (8M)

b) Define protection and deprotection and its importance in organic synthesis? (6M)

OR

8. a) Protection and deprotection of carbonyl group (8M)

b) Explain chemo and regioselective protection and deprotection ? (6M)

UNIT-V

9. a) Explain the structure and synthesis of Pyrazole? (6M)

b) Explain the structure and synthesis of Indole? (8M)

OR

10. Explain the structure and synthesis is of Oxazole , Quinolone and Isoquinolin (14M)

QUESTION BANK


Paper: Organic Chemistry Semester: II

Unit-I

1. Write about the methods of resolutions in Assymetric synthesis?

2. Write a note on Cram‟s Rule and Optical activity in Biphenyls?

3. Explain the stereo chemistry of compounds containing Nitrogen?

4. Write the stereochemistry of compounds containing nitrogen?

5. a) What are ansa compounds? Explain with suitable examples?

b) Give an account about the stereoisomerism exhibited by cyclic compounds?

6. a) What is axial chirality? Explain.

b) Discuss the stereochemistry of allenes and spiranes?

Unit-II

1. What is conformation? Write the conformers of n-butane?

2. Discuss the characteristics of the cyclohexane chair conformation?

3. What are the stereoisomers of decalin? Explain the following in detail.

4. Explain Ring inversion in cis decalin

5. Write the the effect of an angular methyl group in decalin?

6. What are bridged ring systems? How do they differ from fused ring systems?

7. Discuss the Conformations of C-C and C-O bonds, Disubtituted Cyclo Hexanes, Sugars and

Boranes?

8. Write a Note on Decalins, Steric Strain due to Unavoidable Crowding?

Unit-III

1. Write a note on Aldol and Claisen?

2. Write a note on Perkin and Stobbe?

3. Write a note on Knovenagel and Darzen?

4. Write a note on Reformatsky and Benzoin and Dieckmann Condensations?

5. Write a note on Grignard and Cannizzaro?

6. Write a note on Witting and Witting-Horner reactions?

7. Write a note on Favorskii rearrangement and Mannich?

8. Write a note on Michael and Reimer-Tiemann Reaction?

Unit-IV

1. Write the importance of functional group protection an Deprotection in organic synthesis?

2. Write about protection and deprodtection of Amino and carboxylic acids?

3. What are C-C multiple bonds in organic synthesis with suitable Examples?

4. Write a note on Chemo selectivity and region selective protection and deprotection?

5. Protection and deprotection carbonyl compounds?

6. Protection and deprotection of hydryxyl functional group?

Unit-V

1. Synthesis and reactivity of Pyrazole and Imidazole?

2. Synthesis and reactivity of Oxazole and Iso-Oxazole?

3. Synthesis and reactivity of Thiazole and Isothiazole?

4. Synthesis and reactivity of Pyrazine and Pyrimidine?

5. Synthesis and reactivity of Pyridazine and Indole?

6. Synthesis and reactivity of Indole, Quinoline and Isoquinoline?




I M.Sc II Physical Chemistry OCH20417 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives:

To provides a basic understanding of the core area of physical chemistry, based around the theme of

systems, states and processes. Topics covered are chemical thermodynamics and equilibria, and

kinetics.

A good understanding of physical chemistry is important to students intending to complete a major

or minor study in chemistry, and it lies at the borderline with engineering.

Demonstrate a basic understanding of organic chemistry principles to effectively solve problems

encountered in everyday life and in science using appropriate computational

outcomes

On successful completion of the course students will be able to:

Developed an understanding of the breadth and concepts of physical chemistry;

Developed an understanding of the role of the chemist and chemical engineer in tasks

employing physical chemistry

An understanding of methods employed for problem solving in physical chemistry;

Experience in some scientific methods employed in basic and applied physical chemistry

Developed skills in procedures and instrumental methods applied in analytical and practical

tasks of physical chemistry.

Developed skills in the scientific method of planning, developing, conducting, reviewing

and reporting experiments.



SEMISTER II

PAPER IV, PHYSICAL CHEMISTRY, 60 Hrs (4Hrs/Weak) OCH20417

UNIT – I 12 Hours

Thermodynamics II: Third law and Statistical thermodynamics Nernst Heat theorem - Third law of

thermodynamics - Its limitations - Determination of absolute entropy - concept of distribution -

Thermodynamic probability and most probable distribution-Ensembles-Maxwell-Boltzmann

distribution. Partition function - Fermi-Dirac statistics - Bose Einstein statistics- Entropy and

probability - Boltzmann-Plank equation - calculation of thermodynamic properties in terms of

partition function - Translational, rotational and electronic partition function - Entropy of

Monoatomic gases (Sackur -Tetrode equation).

UNIT–II 12 Hiours

Polymer chemistry- Classification of polymers - Free radical , ionic and Zeigler -Natta

Polymerisation - kinetics of free radical polymerisation - Techniques of polymerisation - Glass

transition temperature - Factors influencing the glass transition temperature. Number average and

Weight average, Molecular weights –molecular weights determination- End group analysis -

Osmometry - Light scattering and ultra centrifugation

methods.

UNIT – III 12 Hours

Electrodes: Reference electrodes - Standard hydrogen electrode . Calomel electrode -Indicator

electrodes: Metal-metal ion electrodes - Inert electrodes -Membrane electrodes. potentiometric

titrations, advantages and applications of potentiometric titratons.

Electrode potentials - Double layer at the interface - rate of charge transfer - Decomposition

potential - Over potential - Tafel plots - Derivation of Butler-Volmer equation for one electron

transfer - electro chemical potential.

UNIT–IV 12 Hours

Chemical kinetics - Branching Chain Reactions - Hydrogen-oxygen reaction - lower and upper

explosion limits - Fast reactions - Study of kinetics by flow methods - Relaxation methods - Flash

photolysis - Mechanism of homogeneous catalysis - Acid base catalysis -protolytic and prototropic

mechanism . Enzyme catalysis - Michaelis-Menten kinetics.

UNIT-V 12 HOurs

Photochemical Reactions:

Quantum yield and its determination - Actinometry - Reactions with low and high quantum yields-

Reason – Jablonsky diagram, Singlet and Triplet states, Photo sensitisation - Exciplexes and

Excimers - Photochemical equilibrium - Chemiluminescence - Derivation of fluorescence and

phosphorescence quantum yields. Kinetics of collisional quenching- Stern -Volmer equation - types

of photochemical reactions-photo dissociation- addition and isomerization reactions with examples-

Photo Galvanic cells.

References:

1. Physical chemistry, G.K.Vemulapalli (Prentice Hall of India).

2. Physical chemistry, P.W.Atkins. ELBS

3. Chemical kinetics - K.J.Laidler, McGraw Hill Pub.

4. Text book of Physical Chemistry, Samuel Glasstone, Macmillan pub.

5. Statistical Thermodynamics - M.C.Gupta.

6. Polymer Sceince, Gowriker,Viswanadham, Sreedhar

7. uantitative Analysis, A.I. Vogel, Addison Wesley Longmann Inc.

8. Physical Chemistry-G.W.Castellan, Narosa Publishing House, Prentice Hall

9. Physical Chemistry, W.J.Moore, Prentice Hall

10. Polymer Chemistry - Billmayer

11. Fundamentals of Physical Chemistry, K K Rohatgi-Mukherjee. Wiley Eastern Ltd publications.

12. Statistical Thermodynamics-M.Dole



Paper: Physical Chemistry Code: OCH20417


UNIT-I

1. a) Derive Maxwell Boltzmann distribution? (8M)

b) Explain 3rd law of thermodynamics? (6M)

OR

2. a) Explain Fermi-dirac statistics? (8M)

b) Explain entropy of monoatomic gases? (6M)

UNIT-II

3. a) Explain glass transition temperature and its factors? (8M)

b) Zeigler-Natta polymerisation. (6M)

OR

4. a) Explain number average and weight average molecular weights? (8M)

b) Ultra centrifugation. (6M)

UNIT-III

5. a) Explain potentiometric titrations and its advantages? (8M)

b) Explain calomel electrode? (6M)

OR

6. a) Derive Butler –Volmer equation? (8M)

b) Explain decomposition potential ? (6M)

UNIT-IV

7. a) Discuss about lower and upper explosion limit ? (6M)

b) Write about Michelis Menton kinetics? (8M)

(OR

8. Explain acid base catalysis? (14M)

UNIT-V

9. a) What is quantum yield and how is it determined? (6M)

b) Derive Stern -Volmer equation? (8M)

OR

10. a) Explain Actinometry? (8M)

b) Explain Photogalvanic cells ? (6M)

QUESTION BANK


Paper: Physical chemistry Semester: II

Unit-I

1. Explain thermo dynamical properties and Most probable distribution by taking suitable

examples?

2. Discuss Fermi dirac statistic?

3. What are partition functions derive an expression for Translation and rotational partition

function od diatomic molecule?

4. Discuss absolute entropy of H2O?

5. Write a note on Boltzmann-Plank equation?

6. Write a note on Sackur – Tetrode equation?

Unit-II

7. Mechanism of coordination polymerisation?

8. What is glass transition temperature and factors influence glass transition temperature?

9. Explain the End group analysis using suitable examples?

10. Explain the determination of molecular weight polymers by Ultra centrifugation method?

11. Write a note on classification of polymers

12. Tacnics of polymerisations?

Unit-III

13. Write a note on Indicator electrodes?

14. Explain decomposition potential and over potential by taking suitable examples?

15. Write a bote on fules cells?

16. Derive Butler Volmer equation for one electron transfer?

17. Write a note on reference or electrodes?

18. Write a note on Tafel plots?

Unit-IV

19. Discuss the principle involved in relaxation methods?

20. Write about MICHELIS MENTON equation/kinetics for enzymatic catalysis?

21. Discuss in detail branched chain reactions?

22. Write a note on flash photolysis.

23. Discuss about upper and lower explosion limits.

24. Write a note on Acid base catalysis-protolytic and prototropic mechanism?

Unit-V

25. Write a note on Quantum yield and its determination – Actinometry?

26. Write a note on Reactions with low and high quantum yields – Reason?

27. Write a note on Jablonsky diagram, Singlet and triplet states?

28. Write a note on Photo sensitisation – Exciplexes and Excimers?

29. Write a note on Photochemical equilibrium – Chemiluminescence?

30. Write a note on Derivation of fluorescence and phosphorescence quantum yields?

31. Write a note on Kinetics of collisional quenching – Stem – Volmer equation?

32. Write a note on types of photochemical reactions-photo dissociation – addition and

isomerization reactions with examples?

33. Write a note on Photo Galvanic cells?




II M.Sc

III Organic Spectroscopy OCH30117 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives:

Introduce the theory of the various instruments and the signals produced when analysing

compound.

Equip the student with enough information to be able to interpret signals from spectroscopic

instruments.

Know how nuclear spins are affected by a magnetic field, and be able to explain what happens

when radiofrequency radiation is absorbed.

Be able to predict the number of proton and carbon NMR signals expected from a compound

given its structure.

Be able to predict the splitting pattern in the proton NMR spectrum of a compound given its

structure.

With the aid of a chart of chemical shifts from 1H and 13C NMR, be able to assign peaks in an

NMR spectrum to specific protons in a compound.

Outcomes

To develop expertise relevant to the professional practice of chemistry

To develop an understanding of the range and chemistry of elements in the periodic table and

their compounds

To establish an appreciation of the role of inorganic chemistry in the chemical sciences

To develop an understanding of the role of the chemist in measurement and problem solving in

inorganic chemistry

To provide an understanding of chemical methods employed for problem solving involving

inorganic systems

To provide experience in some scientific methods employed in inorganic chemistry

To develop skills in procedures and instrumental methods applied in analytical and synthetic

tasks of inorganic chemistry.

SEMESTER – III

PAPER – I ORGANIC SPECTROSCOPY Code: OCH30117

UNIT-1

UV- Visible Spectroscopy: Mechanics of measurement – Energy transitions – Simple

chromophores – Auxochrome, Absorption shifts (Bathochromic shift, Hypsocromic shift, Hyper

chromic shift, Hypo chromic shift). UV absorption of Alkenes - Woodward -Fieser rules –

polyenes, unsaturated cyclic systems . UV absorption of Carbonyl compounds, α,β-unsaturated

carbonyl systems - UV absorption of aromatic systems – solvent effects – geometrical isomerism –

acid and base effects – typical examples – calculation of λmax values for simple molecules.

UNIT – II

IR Spectroscopy: Fundamental modes of vibrations -Stretching and bending vibrations – Factors

effecting vibrational frequency-hydrogen bonding - Finger print region and its importance. Typical

group frequencies for – CH, -OH, -NH, -CC, -CO and aromatic systems - Application in structural

determination Examples – simple problems.

UNIT – III

Nuclear Magnetic Resonance Spectroscopy (1HNMR – First Order PMR) Introduction:- Basic

principle of -NMR Nuclear spin-nuclear resonance-saturation, Relaxation- Instrumentation (CW &

FT) shielding and de shielding of magnetic nuclei- chemical shift and its measurements, factors

influencing chemical shift, spin–spin interactions and factors influencing spin -spin coupling

Dynamic NMR- coupling constant J and factors effecting J value, chemical shift values for simple

organic molecules.

UNIT – IV

Electron Spin Resonance Spectroscopy: Basic principles, zero field splitting and Krammers‟s

degeneracy, factors affecting the „g‟ value. Isotropic and anisotropic hyperfine coupling constants –

applications involving organic radicals.

UNIT – V

Mass Spectrometry : Introduction- ion production-EI, CI, ES, MALDI and FAB-molecular ion

peak, meta stable peak, Nitrogen rule. determination of Molecular weight and formulae- Isotopic

Peaks . Mass spectral fragmentation of organic compounds, common functional groups, Mc-

Lafferty rearrangement. Examples of mass spectral fragmentation of organic compounds with

respect of their structure determination.

SUGGESTED BOOKS:

1) Spectroscopic Methods in Organic Chemistry. Forth Edition D.M. Williams and I. Fleming Tata

- McGraw Hill, New Delhi, 1990.

2. Spectrometric identification of organic compounds by R.N.Silverstein & G.C.Bassier (John

Willey)

3. Applications of absorption spectroscopy of Organic Compounds J.R.Dyer, Prentice

Hall of India, New Delhi, 1984.

4. Introduction to Spectroscopy – D. L. Pavial, G.M. Lampman, G.S. Kriz, 3rd

Ed. (Harcourt

college publishers.

5. Spectroscopic identification of Organic compounds – R.M. silverstein, F.X. Webster, John

Wiley.

6. Organic Spectroscopy, Second Edition, W.Kemp, ELBS Macmillan, 1987.

7. Absorption Spectroscopy of organic molecules – V.M. Prakash.


Class: II M.Sc Organic Chemistry Semester: III Paper: Organic Spectroscopy Code: OCH 30117


UNIT-I

1. a) Write Wood-Ward Fieser rules for carbonyl compounds? (8M)

b) Write the factor effecting UV absorptions? (6M)

OR

a) Types of absorption shifts? (8M)

b) Write about note on auxochromes and chromophores?

UNIT-II

2. a) Write a note on fundamental modes of vibration? (8M) b) Write about solvent effect on IR spectroscopy? (6M) OR

a) Write about the factors effecting IR spectroscopy? (8M) b) Write a note on fictional group and finger print region? (6M)

UNIT-III

3. a) Write a note on FT-NMR? (8M) b) Write a note on factors effecting chemical shift? (6M)

OR

a) Define coupling constant and factors effecting coupling constants? (8M)

b) Write a note on Anisotropic effect? (6M)

UNIT-IV 4. a) Write briefly about the Production technics EI, CI, ES in mass

spectroscopy? (8M)

b) Write about different types of Peaks in mass spectrometion? (6M)

OR

a) Define MC (affects) rearrangement and Nitrogen rule? (8M)

b) Fragmentation of Amides and amines? (6M)

UNIT-V

5. a) Write Zero – Field splitting in ESR, krammers Degeneracy? (8M) b) Explain Hyper fine splitting and factors effecting g value? (6M)

OR a) Explain isotropic and anisotropic coupling constants? (8M)

b) Write the applications of ESR to organic radical? (6M)

QUESTION BANK


Paper: Organic Spectroscopy Semester: III

Unit-1

1. Define Beers - Lambert‟s law and explain the reasons for deviation.

2. Calculate the values for the following compounds using Woodward –Fisher‟s rules

3. Describe Woodward –Fisher‟s rules With relevant examples?

4. Write a note on Bathochromic shift and hypso chromic shift?

5. Explain the effect of solvation for unsaturated carbonyl compounds in UV-spectroscopy?

6. How UV-spectroscopy is useful in establishing the configuration of cis and trans isomers?

7. State and explain molar extension coefficient?

8. Octant rule and cotton effect?

9. Applying Octant rule predict the cotton effect for 3- bromo cyclo hexanone (both axial and

equatorial)?

10. Write short note on chromophores and auxochromes, UVabsorption of unsaturated cyclic

systems, acids base effects in UV-spectroscopy?

11. Explain why biphenyl in its uv spectrum has an absorption band at 250 nm , while 2-methyl

biphenyl has at 237 nm.

UNIT-2

1. What is the importance of hydrogen bonding in IR spectra.

2. How can you identify carbonyl compounds in IR spectroscopy . Explain with examples.

3. Comment on the phases or media used for measuring IR spectra of solids & liquids.

4. What are molecular vibrations . Explain in detail the modes of vibrations with at least 2 types of

examples.

5. How would you distinguish the following sets of compounds using IR spectra.

i) Methyl benzoate & phenyl acetate

ii) Mono and Di substituted benzene

iii) primary, secondary , and tertiary amines

iv) cis and trans isomers of cinnamic acid

v) Ortho and para quinones

6. Write a shrot note on finger print region, typical group frequencies for aromatic systems,

applications in structure determination of organic compounds?

7. Symmetric alkynes do not show IR band for the alkyne band, while unsymmetric alkynes show

absorption. Explain

8. KBr disc is the most suitable over niyolmull or solution for running IR spectra . Explain

9. Disscus which IR bands could help in distinguishing the following pairs.

i) 4-amino methyl benzoic acid and 4-amminophenyl acetic acid

ii) Butanamide and N-methyl propanamide

iii) cis and trans isomer of 3-hexane

iv) 1-hexyne and 3-hexyne

10.The absorption of benzal acetone in CS2 is 1674cm-1 for the cis and 1699cm-1 for the trans

isomer. Explain

11. How do you distinguish the following compounds IR spectra.

i) Cyclo pentane and cyclo hexane

ii) Benzaldehyde and acetaldehyde

iii) Teritiary alcohol & primary alcohol

iv) Ethylene & acetylene

UNIT-III

1. Explain the basic principle involved in proton NMR spectroscopy.

2. Write the factors influencing chemical shift.

3. Define coupling constants and factors effecting coupling constants.

4. Define chemical shift.

5. Instrumentation of NMR.

6. Write the shielding and deshielding effects of NMR.

UNIT – IV

1. Write the principle involved in ESR.

2. Explain zero field splitting and Krammers‟s degeneracy.

3. Write the factors affecting the „g‟ value.

4. Define Isotropic and anisotropic effects.

5. Write the applications of ESR for organic radicals.

UNIT – V

1. Write the ion production techniques in mass spectrometry.

2. Define meta stable peek and molecular ion peek.

3. Write the fragmentation of carboxylic acids.

4. Explain Mc Lafferty rearrangement.

5. Define Nitrogen rule.

6. Explain the mass fragmentation in alcohols.

7. Explain the mass fragmentation in carbonyl compounds.




II M.Sc III

Organic Reaction Mechanisms

And Green Chemistry OCH30217 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives

To extend knowledge of important reaction mechanisms, building upon first and second

year organic chemistry. Strategies in organic synthesis, reactivity, molecular

rearrangements

The overall objective is for the student to master the nomenclature, structure, synthesis,

and reactions of the principal classes of organic compounds.

The secondary objective of this course is to increase the student‟s knowledge of the

involvement of organic chemistry in everyday life, prepare the students for GRE, MCAT,

and upper level organic courses.

To provide the students with knowledge and the basic understanding of nanotechnology.

Paper II ORGANIC REACTION MECHANISMS AND GREEN CHEMISTRY

Code: OCH30217

UNIT-I 12 Hours

Methods for determining Reaction mechanisms by kinetic and non-kinetic studies.

Kinetics of reaction, Energetics of reaction, Energy profile diagram, Intermediate versus transition

state, Reaction rate and rate limiting step, kinetic Vs thermodynamic control, Identification of

products, testing possible intermediates, trapping of intermediates, Cross over experiments, Isotopic

labelling, stereo chemical studies.

UNIT-II 12 hours

Free radicals and their reactions: Introduction, formation, detection and stability of radicals.

Some radical reactions, Addition of halogens, Hydrogen halides. Substitution reactions-

Halogenation, Aromatic substitution, Sandmayer reaction, Autooxidation, Decomposition of

dialkyl and diacyl peroxides.

UNIT-III 12 hours

Oxidations: Introduction, Different Oxidative processes. Oxidation of Hydrocarbons: alkenes-

Ozonolysis, Epoxidation, perhydroxylation, aromatic rings, saturated C-H groups (activated and

unactivated), oxidation of Alcohols-Cr(VI) reagents, MnO2, Ag2CO3, Oppenauer oxidation, diols-

lead tetra acetate, aldehydes, Ketones-per acids, Carboxylic acids. Oxidations with ruthenium

tetroxide and Tl(III) nitrate, selenium dioxide.

UNIT-IV 12 hours

Reductions: Introduction: Catalytic hydrogenations- Heterogeneous and Homogeneous, Reduction

by dissolving metals, Reduction with metal in liquid ammonia (Birch reduction).Reduction with

metal and acid-Clemensons reduction, Reduction by hydride transfer reagents- Aluminium

alkoxide, LiAlH4, NaBH4, Diisobutyl aluminium hydrides, Sodium cyano borohydride ,trialkyl

borohydirdes, Reduction with diimide, Wolff-Kishner reduction.

UNIT-V 12 hours

Green Chemistry : Introduction, Principles & concepts of Green chemistry, Green Catalysis,

Biocatalysis, renewable resources, Green Reagents, examples of green reactions-synthesis of

Ibuprofen, Clean Fischer-Indole synthesis, comparison of the above with conventional methods.

Introduction to Microwave organic synthesis, Applications: solvents (water and organic solvents),

solvent free reactions (solid state reactions).

SUGGESTED BOOKS:

1. Mechanism and structure in Organic Chemistry “ E.S.Could Henry – Holt and Co, New york

2. Advances in Organic Reaction mechanism and structure J. March (McGrew Hill)

3. Aguide Book to Mechanism in Organic Chemistry” by P.Sykes

4. Synthetic approaches in organic chemistry by R.K.Bansal(Narosa Publications)

5. Some modern methods of synthesis by Carruthers ( Cambridge)

6. Anastas, P.T.; Warner, J. C., Green Chemistry, Theory and Practice, Oxford University Press,

Oxford, 2000. ISBN: 0 19 850698 8 (Paperback).

7. Green chemistry, V.K.Ahluwalia , Ane books.

8. P.T. Anastas and J.C.Warner Green chemistry, Oxford.


Class: II MSc Organic Chemistry Semester: III

Paper: Organic Reaction Mechanisms And Green Chemistry Code: OCH30217


UNIT-I

1. a) Energy Profile diagrams ? (8M)

b) Write a note on intermediate (VS) Transition state? (6M)

OR

a) Write a note on kinetically controlled and thermodynamically controlled

reaction? (8M)

b) Write about cross over experiments and isotopic labeling? (6M)

UNIT-II

2. a) Write the methods for the detection of free radicals? (8M)

b) Write the Mechanism for halogenation of alkenes. (6M)

OR

a) Write the Mechanism of Sand Mayer reaction and Auto oxidation? (8M)

b) Write the mechanism for dialkyl and diacyl peroxides decomposition.

(6M)

UNIT-III

3. a) Write a note on epoxidation and Ozonolysis . (8M)

b) Explain the oxidation of alcohols using Cr(VI) oxidants. (6M)

OR

a) Explain the oxidation of ketones using perscids. (8M)

b) Write the synthetic applications of the following reagents.

1. Ruthenium tetroxide 2) Tl(III) Nitrate (6M)

UNIT-IV

4. a) Write a note on Homogeneous catalytic hydrogenation. (8M)

b) Write a note on Clemensons reduction. (6M)

OR

a) Write a note on Birch Reduction. (8M)

b) Explain the reduction by lithium aluminium hydride and sodium

borohydride (6M)

UNIT-V

4. a) Write 12 Principles of green chemistry (8M)

b) write briefly about atom economy. (6M)

OR

a) Write a note on Clean Fischer Indole synthesis (8M)

b) Write a note on micro wave organic synthesis (6M)

QUESTION BANK


Paper: Organic Reaction Mechanisms And Green Chemistry Semester: III

UNIT-I

1. Write a note on Kinetics of reaction?

2. Write a note on Energy profile diagram?

3. Write a note on Intermediate versus transition state?

4. Write a note on Reaction rate and rate limiting step?

5. Write a note on kinetics Vs thermodynamic control?

6. Write a note on Identification of products, testing possible intermediates, trapping of

intermediates?

7. Write a note on Cross over experiments, Isotopic labelling, stereo chemical studies?

Unit-II

1. Write a note on formation, detection and stability of radicals?

2. Write a note on Some radical reactions, Addition of halogens, Hydrogen halides?

3. Write a note on Substitution reactions-Halogenation?

4. Write a note on Aromatic substitution of freeradicals?

5. Write a note on Sandmayer reaction?

6. Write a note on Autoxidation Decomposition of dialkyl and diacyl peroxides?

Unit-III

1. Explain the synthetic applications of the following OsO4, Thallium-nitrate?

2. Explain the synthetic applications of Lead tetra acetate, Manganese oxide?

3. Give a detailed explanation of ozonolysis with suitable examples?

4. Write notes on Oppenauer oxidation, Periodate oxidation, Ag2CO3, Chromium VI?

5. Write an account of the selective oxidation of alkyl side chain in aromatic compounds?

6. Discuss the role of chromic acid in the oxidation of alcohols?

7. Explain the advantages with chromium trioxide-pyridine reagent?

8. Write note on Peroxy acids?

9. Explain the mechanisms and applications of the following reagents in organic synthesis-----

Chromic acid, Manganese, RuO4, Oxide?

Unit-IV

1. Write short note on Birch reduction?

2. Write is diimide? How it is generated. Discuss the mechanisms of addition of diimide to

Cis-alkenes?

3. Explain reduction of carbonyl compounds with suitable examples?

4. Write short notes on the use of following reagents in organic synthesis--- NaBH4,

Aluminium alkoxides, Trialkyl borohydrides?

5. Explain in detail how dissolving metals and hydride transfer reagents are useful in reduction

of carbon compounds with suitable examples?

6. What is catalytic hydrogenation. Explain with an examples?

7. Write short notes on---- Birch reduction, Reduction with aluminium alkoxide?

8. What is hydroboration? Explain with suitable examples?

9. Give a detailed account of synthetic applications of--- LiAIH4, di-isobutyl aluminium

hydrides?

Unit-V

1. Write the twelve principles of Green Chemistry?

2. Write the Green synthesis of lbuprofen and compare it with the conventional method?

3. Explain the clean Fisher-Indole synthesis?

4. Explain the solvent free reaction with examples?

5. Write a note on multi step vs single pot synthesis?




II M.Sc III Organic Synthesis OCH30317 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives

The objective of the course is for students to develop an understanding and appreciation of

both structure and chemical transformations of organic molecules.




The basis for and principles of retrosynthetic analyses are thoroughly presented and

discussed and subsequently applied to work out synthetic strategies for complex organic

molecules. An overview is given of the most important reactions used in organic synthesis,

with particular emphasis on relevant stereochemical aspects which are discussed on the basis

of mechanistic facts.

Learning Outcomes


expected outcome.

Use retrosynthetic analysis to work out and compare alternative syntheses of complex

organic molecules.

Outline important classical and modern reactions used in organic synthesis.

Discuss how reaction conditions influence the outcome of important reactions with respect

to regio- and stereoselectivity. present in some detail classical syntheses of some natural

products.

Paper III ORGANIC SYNTHESIS Code: OCH30317

UNIT- I 12 hours

Formation of carbon-carbon single bonds: Alkylations of relatively acidic methylene groups,

alkylations of ketones, alkylations via enolates, enamine and related reactions, umpolung (dipole

inversion). The aldol reaction . Allylic alkylation of alkenes, alkylation of α-thio carbanions- α-

seleno carbanions, formation of carbon carbon single bonds by the addition of free radicals to

alkenes, synthetic applications of carbenes and carbenoids.

UNIT-II 12 hours

Formation of carbon-carbon double bonds: Sulphoxide-sulphonate rearrangement, synthesis of

allyl alcohols, the wittig reaction, alkenes from sulphones, decarboxylation of β-lactones, alkenes

from aryl suphonyl hydrazones, Claisen rearrangement of allyl vinyl ethers. Stereo selective

synthesis of tri and tetra substituted alkenes, fragmentation reactions, oxidative decarboxylation of

carboxylic acids, stereospecific synthesis from 1,2-diols, reductive dimerization of carbonyl

compounds.

UNIT-III 12 hours

Diels–Aider and related reactions: Different types of dienes and dienophiles, Intra molecular

Diels –Alder reaction, stereochemistry and mechanism of Diels – Alder reaction, Retro Diels- Alder

reaction, photosensitized Diels- Alder reactions, The ene reaction, 1,3-dipolar cycloaddition

reactions.

UNIT-IV 12 hours

Reactions at unactivated C- H bonds: The Hoffmann – Loeffler – Freytag reaction, Cyclisation

reactions of nitrenes, The Barton reaction and related processes, photolysis of organic nitrites and

hypohalites, photolysis of Nnitroso amides.

Reaction of monohydric alcohols with lead tetraacetate, Miscellaneous reactions, unsaturated

alcohols from hydroperoxides, cyclobutanols by photolysis of ketones, long- range functionalisation

of unactivated carbons on the steroid nucleus.

UNIT-V 12 hours

Disconnection approach: Introduction to Disconnection approach with suitable examples, FGI,

Synthon, synthetic equivalents, One group C-X disconnections, One group C-C disconnections-

Alcohols, carbonyl compounds, C-N Disconnections. Chemo, regio and sterio selectivity with

examples. Linear and convergent synthesis with example.

SUGGESTED BOOKS:

1. Modern Methods of Organic Synthesis, W. Carruthers, Cambridge Press

2. 2. Organic Synthesis by H. O. Houe

3. 3. Modern Method of Organic Syntheis, Carruthers and Coldham Sachin Kumar Gosh,

Cambridge, New Central Book Agency.

4. Advances in Organic Reaction Mechanism and Structure, J. March Mc. Grew Hill

5. Organic Synthesis: The disconnection approach, S. Warrant John Wiley and sons, New

York.

6. Modern Synthetic Reactions, Herbet O. Horase, Second Edition, W.A. Benzamine Inc.

Menio Park, California, 1972.



Paper: Organic Synthesis Code: OCH30317


UNIT-I

1. a) Write a short note on the following.(14M)

(i) Alkylation of ketones

(ii )Allylic alkylation of alkenes.

OR

2. a) Explain the significance of “umpolung”in C-C single bond formation.(8M)

b) Explain the formation of carbon-carbon singlebond by the addition of free radicals to

alkenes.(6M)

UNIT-II

3. a) Explain Sulphoxide-sulphonate rearrangement.(8M)

b) Discuss in detail the Claisen rearrangement of “allyl vinyl ethers” with examples (6M)

OR

4. a) ynthesis of allyl alcohols.(8M)

b) Explain the oxidative decarboxylation of carboxylic acids (6M)

UNIT-III

5. a) Explain the “Intra molecular Diels-Alder reaction” with suitable examples.(8M)

b) Explain the mechanism of the photosensitized diels alder reaction(6M)

OR

6. a) Explain the stereochemistry and mechanism of Diels –Alder reaction.(8M)

b) Explain the stereochemistry and mechanism of “Retro Diels –Alder” reaction. (6M)

UNIT-IV

7. a) Explain various cyclisation reactions of nitrenes.(8M)

b) Expalin the Barton reaction and related processes.(6M)

OR

8. a) Write a short note on photolysis of N-nitrosoamides with examples. (8M)

b) Write a short note on photolysis of organic nitrites and hypohalites. (6M)

UNIT-V

9. a) Explain FGI , synthetic equivalents.(8M)

b) Discuss in detail the one group C-C disconnection in alcohols with examples.(6M)

OR

10. a) Discuss in detail one group C-X disconnections with examples.(8M)

b) Write about chemo ,region and sterioselectivity with examples.(6M)

Question Bank


Paper: Organic Synthesis Code: OCH30317


UNIT-I

1. Discuss briefly the alkylations of relatively acidic methylene groups with examples.

2. Write a short note on the following.

(i) Alkylation of ketones

(ii )Allylic alkylation of alkenes.

3. Explain enamine and related reactions.

4. Explain the significance of “umpolung”in C-C single bond formation.

5. Write a note on the Aldol reaction with suitable examples.

6. Discuss briefly the alkylation of α-thiocarbanions and α-selenocarbanions with examples.

7. Explain the synthetic applications of carbenes and carbenoids.

8. Explain the formation of carbon-carbon singlebond by the addition of free radicals to alkenes.

UNIT-II

10. Explain Sulphoxide-sulphonate rearrangement.

11. Write a note on the following.

12. Fragmentation reactions.

13. Witting reaction.

14. Write a short note on the following.

15. Synthesis of allyl alcohols.

16. Decarboxylation of β-lactones.

17. Discuss in detail the Claisen rearrangement of “allyl vinyl ethers” with examples.

18. Explain the stereo selective synthesis of tri and tetra substituted alkenes.

19. Explain the oxidative decarboxylation of carboxylic acids.

20. Explain the stereospecific synthesis from 1,2 diols with suitable examples.

12. Write briefly about the reductive dimerisation of carbonyl compound.

UNIT-III

1. Define the terms dienes and dienophile .Explain their synthetic utility in organic synthesis

with examples.

2. Explain the “Intra molecular Diels-Alder reaction” with suitable examples.

3. Explain the stereochemistry and mechanism of Diels –Alder reaction.

4. Explain the stereochemistry and mechanism of “Retro Diels –Alder” reaction.

5. Explain the mechanism of the photosensitized diels alder reaction.

6. Explain the ene reaction.

7. Describe briefly the 1,3 –dipolar cycloaddition reactions.

UNIT-IV

1.Explain HLF reaction.

2. Explain various cyclisation reactions of nitrenes.

3. Expalin the Barton reaction and related processes.

4. Write a short note on photolysis of N-nitrosoamides with examples.

5. Write a short note on photolysis of organic nitrites and hypohalites.

6. Write about the reaction of monohydric alcohols with lead terta acetate with examples.

7. Explain miscellaneous reactions.

8. Explain formation of cyclobutanols from photolysis of ketones.

9. Explain the long-range functionalism of unactivated carbons on the steroid nucleus.

UNIT-V

1. Explain disconnection approach with suitable examples.

2. Explain FGI , synthetic equivalents.

3. Discuss in detail the one group C-C disconnection in alcohols with examples.

4. Discuss in detail one group C-X disconnections with examples.

5. Write about chemo ,region and sterioselectivity with examples.

6. Explain the linear and convergent synthesis with examples.




II M.Sc

III Organo Metallic Chemistry &

Natural products

OCH30417 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives

To describe the synthesis and general properties of organometallic compounds

An introductory understanding of Bio-inorganic chemistry.

Give students an awareness of the richness and diversity of plants and animal around them.

Outcomes

To recognize organometallic ligands and compounds

Knowledge of fundamental organometallic reactions

Knowledge of a variety of organometallic based catalytic reactions, including a mechanistic

understanding including enzymatic reactions

Provide an overview of the field of natural product chemistry.

Identify different types of natural products, their occurrence, structure, biosynthesis and

properties.

PAPER – IV Organo Metallic Chemistry and Natural Products Code: OCH30417

UNIT-I 12 hours

Organo boranes: Preparation of Organoboranes-alkylboranes, alkenylboranes,

dicylohexylboranes, disiamylborane, thexylborane, 9-BBN and catacol boranes viz hydroboration

with BH3-THF, protonolysis, oxidation, isomerization, cyclization, rearrangements and free radical

reactions of organoboranes, reactions with α- bromoketones, α-bromoesters, functional group

transformations of organoboranes, The cyanoborate process and reaction of alkenylboranes and

trialkenyl borates.

UNIT-II 12 hours

Organo silanes: Synthetic applications of organosilicon compounds, protection of –OH functional

groups, trimethyl silly ethers, sillylenolethers, trimethyl silyl chloride, dimethyl-t-butylsilyl

chloride, trimethyl silyl cyanide, trimethyl silyliodide,trimethylsilyltriflate, Peterson olefination.

Synthetic applications of·. α-silylcarbanion and β-silyl carbonyl compounds, alkenyl silanes, allyl

silanes, The β-effect, control of rearrangement of carbonium ions by silicon.

UNIT-III 12 hours

Organo metallic reagents: Preparation of Grignard reagents with alkyl, allyl and propargyl

halides, alkylation, reaction with carbonyl compounds, esters, alcohols, amines, acids, cabon

dioxide, carbon disulfide, sulphur dioxide. Preparation of alkyllithium, reagents, lithium diisopropyl

amide (LDA),and uses in aromatic annulation and hetero aromatic annulations. π-allylnickel

complexes, preparation of 1,5-cyclic dienes, nickel carbonyl, Organocopper reagents; organo

cuprates, lithium organo cuprates, Gilman reagents, oxidative coupling of terminal alkynes,

alkylations. Organo palladium reagents, preparation of Palladium reagents, π- allyl palladium

complexes, synthetic applications of organo palladium reagents.

UNIT-IV 12 hour

Natural products: Alkaloids: Definition, nomenclature and physiological action, occurrence,

isolation, general methods of structure elucidation, degradation, classification based on nitrogen

heterocyclic ring, Structure, synthesis of the following: Nicotine, Atropine, Morphine.

Terpenoids: Classification, nomenclature, occurrence, isolation, general methods of structure

determination, isoprene rule. Structural determination and synthesis of the following molecules: α-

terpeneol, Farnesol and zingiberene.

UNIT-V 12 hours

Vitamins: Classification, sources and biological importance of vitamins.

Synthesis of B1, B2, B6, folic acid.

Flavonoids: Synthesis of Flavonoids- Quercetin and Kaempferol.

Anti-Biotics: Classification of Anti biotics- synthesis of Pencillin- Chlorophenecol- Ampicillin-

Streptomycin.

SUGGESTED BOOKS:

1. Organic Chemistry, Volume 2, Stereochemistry and chemistry of natural

products, I.L. Finar, 5th

Edition. ELBS, 1975.

2. The Chemistry of Natural Products Vol.II Mono and Sesqui-Terpenes" by P.De Mayo (John

Wiley Inc).

3. The Vitamins by S.F. Dykes.,

4. Biological Chemistry by Holum,

5. General Organic and Biochemistry by F.A.Bettelheim and Jerry March, Saunders

6. Alkaloids by Bently.



Paper: Organo Metallic Chemistry and Natural Products Code: OCH30417


Unit- I

1. A. Write a note on Hydroboration, Protonolysis, Oxidation and Isomerisation 8 M

B. Write the preparation and properties of disimyl borane and 9BBN 6M

(OR)

2. A. Write a note on reactions of α-bromoketones and α- bromoesters 8 M

B. Write the reactions of alkenyl boranes. 6 M

Unit- II

3. A. Write the synthetic applications of organo silicon compounds 8 M

B. Write a note on synthetic applications of trimethyl silyl Iodide 6 M

(OR)

4. A. Write a note on synthetic applications of α- silyl carbanions and β-silyl carbonyl

compounds. 8 M

B. Write a note on control rearrangement of carbonium ions by silicon 6 M

Unit- III

5. A. Write the preparation of Grignard reagents with Alkyl,Allyl and Propargyl hallides.

8 M

B. Write the preparation and synthetic applications of alkyllithium compounds 6 M

(OR)

6. A. Write the preparation and synthetic applications of π- allylnickel complexes. 8 M

B.Write the preparation and synthetic applications of π- allylpalladium complexes 6M

Unit- IV

7. A. Write the general methods for the determination of structure of Alkaloid 7 M

B. Write the structural elucidation and synthesis of Morphine. 7 M

(OR)

8. A. Write the structural elucidation and synthesis of α- terpeneol 7 M

B. Write the structural elucidation and synthesis of Farnesol 7 M

Unit- V

9. A. Write the classification, sources and biological importances of Vitamins 6 M

B. Write the synthesis of B1 and folic acid 8 M

(OR)

10. A. Write the synthesis of Antibiotics Pencillin and Chlorophenecol 8 M

B. Write the synthesis of Flavonoids 8 M

Question Bank


Paper: Organo Metallic Chemistry and Natural Products Code: OCH30417

Unit-I

1. Write a note on Preparation of Organoboranes-alkylboranes?

2. Write a note on alkenylboranes dicylohexylboranes, disiamylborane?

3. Write a note on hydroboration with BH3-THF, protonolysis, oxidation,

isomerizarion, cyclization?

4. Write a note on free radical reactions of organoboranes?

5. Write a note on the cyanobotate process and reaction of alkenylboranes

and trialkenyl borates?

Unit-II

1. Write a note on Syntheitc applications of organosilicon compounds?

2. Write a note on protection of –OH functional groups, trimethyl silly ethers,

sillylenolethers?

3. Write a note on trimethyl silyl chloride, dimethyl-t-butylsilyl chloride?

4. Write a note on trimethyl silyl cyanide, trimethyl silyliodide, trimethylsilyl

triflate, Peterson olefination?

5. Wr -silylcarbanion and β-silyl

carbonyl compounds?

6. Write a note on the β-efect, control of rearrangement of carbonium ions by

silicon?

Unit-III

1. Write a note on Preparation of Grignard reagents & applications?

2. Write a note on Preparation of alkyllithium, reagents?

3. Write a note on LDA?

4. -allylnickel complexes, prepatation of 1,5-cyclec dienes,

nickel carbonyl?

5. Write a note on Organocopper reagents?

6. Write a note on Gilman reagents?

7. Write a note on Organo palladium?

Unit-IV

1. Write a note on Structure, synthesis of the Nicotine?

2. Write a note on Structure, synthesis of Atropine?

3. Write a note on structure, synthesis of Morphine?

4. -

terpeneol?

5. Write a note on Structural determination and synthesis of Farnesol?

6. Write a note on Structural determination and synthesis of Zingiberene?

Unit-V

1. Write the synthesis of B1?



4. Write the synthesis of Quercetin?

5. Write the synthesis of Kaempferol?

6. Write the synthesis of Pencillin?

7. Write the synthesis of Chlorophenecol?

8. Write the synthesis of Ampicillin?

9. Write the synthesis of Streptomycin?




II M.Sc IV Advanced Organic Spectroscopy OCH40117 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives:

Introduce the theory of the various instruments and the signals produced when analysing

compound.

Equip the student with enough information to be able to interpret signals from spectroscopic

instruments.

Know how nuclear spins are affected by a magnetic field, and be able to explain what happens

when radiofrequency radiation is absorbed.

Be able to predict the number of proton and carbon NMR signals expected from a compound

given its structure.

Be able to predict the splitting pattern in the proton NMR spectrum of a compound given its

structure.

With the aid of a chart of chemical shifts from 1H and 13C NMR, be able to assign peaks in an

NMR spectrum to specific protons in a compound.

Course Outcomes


To develop an understanding of the range and chemistry of elements in the periodic table and

their compounds

To establish an appreciation of the role of inorganic chemistry in the chemical sciences

To develop an understanding of the role of the chemist in measurement and problem solving in

inorganic chemistry

To provide an understanding of chemical methods employed for problem solving involving

inorganic systems

To provide experience in some scientific methods employed in inorganic chemistry

To develop skills in procedures and instrumental methods applied in analytical and synthetic

tasks of inorganic chemistry.

SEMESTER–IV

PAPER – I ADVANCED ORGANIC SPECTROSCOPY Code: OCH40117

UNIT-I

Spin system, Nomenclature of spin system, spin system of simple and complex PMR spectra (Study

of AB – A2 – AB2. ABX – ABC – AMX interactions) Simplification of complex spectra- nuclear

magnetic double resonance, chemical shift reagents, solvent effects on PMR Spectrum . Nuclear

Overhauser Effect (NOE).

UNIT-II 13

C-NMR spectroscopy –Similarities and Differences between PMR and CMR-CMR recording

techniques -BBC-BBD-SFORD-Gate pulse CMR spectrum.

General considerations, chemical shift (aliphatic, olefinic, alkyne, aromatic, heteroaromatic and

carbonylcarbon).Typical examples of CMR spectroscopy – simple problems.

UNIT-III

ORD& CD Curves A) Optical rotatory dispersion : Theory of optical rotatory dispersion – Cotton

effect –CD curves-types of ORD and CD curves-similarities and differences between ORD and CD

curves B) α- Halo keto rule , Octant rule – application in structural studies.

UNIT –IV

2D NMR spectroscopy – Definitions, study, importance and applications of COSY, DEPT,

HOMCOR, HETCOR, INADEQUATE, INDOR, INEPT, NOESY, HOM2DJ, HET2DJ,

DQFCOSY. COSY, DEPT, HOMCOR, HETCOR, INEPT, NOESY, HOM2DJ, HET2DJ,

DQFCOSY simple organic compounds.

UNIT-V

Structural determination of Organic compounds Using UV, IR, 1H-NMR,

13C-NMR and mass

spectral values.

SUGGESTED BOOKS:

1. Introduction to Spectroscopy – D. L. Pavia, G.M. Lampman, G. S. Kriz, 3rd Ed. (Harcourt

college publishers).

2. Spectrometric identification of organic compounds R. M. Silverstein, F. X. Webster, 6th Ed.John

Wiley and Sons.

3. Spectroscopic methods in organic chemistry - D. H. Williams and I Flemming McGraw Hill

4. Absorption spectroscopy of organic molecules – V. M. Parikh 5. Nuclear Magnetic Resonance –

Basic Principles- Atta-Ur-Rehman, Springer- Verlag (1986).

6. One and Two dimensional NMR Spectroscopy – Atta-Ur-Rehman, Elsevier (1989).

7. Organic structure Analysis- Phillip Crews, Rodriguez, Jaspars, Oxford University Press (1998)

8. Organic structural Spectroscopy- Joseph B.Lambert, Shurvell, Lightner, Cooks, Prentice-Hall

(1998).

9. Organic structures from spectra –Field L.D., Kalman J.R. and Sternhell S. 4th Ed. John Wiley

and sons Ltd.


Class: II MSc Organic Chemistry Semester: IV

Paper: Advanced Organic Spectroscopy Code: OCH40117


UNIT

1. a) Explain nuclear magnetic double resonance?

b) Explain about J value for AMX, ABC?

Or

2. a) Explain simple and complex PMR spectrum with examples?

b) Explain solvent effects on CMR spectrum?

3. a) Explain various CMR recording techniques?

b) Contact shift reagents?

Or

4. a) Explain about anisotropic effect?

b) What are j value explain their use in structural determination?

5. a) Explain theory of ORD in detail and ORD curves?

b) Explain applications of Octant rule?

Or

6. a) Explain octant, haloketo rule?

b) Explain positive and negative cotton effects?

7. Give importance of HOMCOR, HET2DJ?

Or

8. Explain definitions and importance of COSY, INDOR, HETCOR?

9. Molecular formula: C6H10O2

H NMR : δ (PPM) = 6.97 (dq, J = 6.8 and 15.2 Hz,

1H), 5.83 (d, J = 15.2 Hz, 1H), 4.17 (q, J = 7.2 Hz,

2H), 1.87 (d, J = 6.8 Hz, 3H), 1.27 (t, J = 7.2 Hz,

3H). 13C NMR δ (ppm) = 170.0 144.6 123.0 60.3 18.1 14.5

Discuss the component structure of the given molecule by utilizing the above

NMR data.

Or

10. Give the spectral data for the following compounds.

CH3 – CH2 – CH = CH –OH, C6H5 – CH = CH2

QUESTION BANK

Class: I M.Sc Organic Chemistry Code: OCH$0117

Paper: Advanced Organic Spectroscopy Semester: IV

UNIT – I

1. Write a note on nuclear magnetic double resonance?

2. Chemical shift reagents?

3. Solvent effects on PMR spectrum?

4. Nuclear overhauser Effect (NOE)?

5. Complex PMR spectra of AB, A2, AB2 systems?

6. Complex PMR spectra of ABX, ABC & AMX?

UNIT – II

1. Difference and similarities between PMR and CMR?

2. BBD, BBC?

3. SFORD?

4. Factors affecting C13 chemical shift

5. Calculate Chemical shift values of simple Alkanes and branched alkanes with

examples?

UNIT – III

1. Explain Optical rotatory dispersion?

2. Define Cotton effect?

3. Explain CD curves?

4. Write alpha - Halo Keto rule

5. Explain Octant rule

6. Write the applications of octant rule

UNIT –IV

7. Write a note on COSY, HOMCOSY?

8. Write a note on HETCOSY?

9. Write a note on HOM2DJ, HET2DJ?

10. Write a note on INEPT, DEPT?

11. Write a note on DQFCOSY?

12. Write a note on INADEQUATE?

13. Write a note on INDOR?




II M.Sc IV Organic Reaction Mechanisms

And Nanochemistry

OCH40217 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives

To extend knowledge of important reaction mechanisms, building upon first and second

year organic chemistry. Strategies in organic synthesis, reactivity, molecular

rearrangements

The overall objective is for the student to master the nomenclature, structure, synthesis,

and reactions of the principal classes of organic compounds.

The secondary objective of this course is to increase the student‟s knowledge of the

involvement of organic chemistry in everyday life, prepare the students for GRE, MCAT,

and upper level organic courses.

To provide the students with knowledge and the basic understanding of nanotechnology.

Course Outcomes

Students will be able to draw mechanisms for complex reactions, to predict reactivity, to

appreciate how orbital interactions affect structure and reactivity.

Understand the factors affecting the energies of key intermediates in such reactions, using

that information to predict which intermediates are not reasonable to propose.

Understand and be able to apply the Woodward–Hoffmann rules governing pericyclic

reactions.

Be able to draw properly a chain mechanism.

Understand the need to increase Nanotechnology awareness

Know the processing of Nanoprticles and Nanomaterials and • Know the application of

Nanotechnology and nanomaterials.

PAPER – II ORGANIC REACTION MECHANISMS AND NANOCHEMISTRY

Code: OCH40217

UNIT-I 12 hours

Molecular Rearrangements- Migration to electron deficient carbon atom. Pinacol-Pinacolone

rearrangement, Wagner Meerwein rearrangement, Tiffenev-Demjanov ring expansion, Benzil-

Benzilic acid rearrangement and Favorski rearrangement. Migration to electron deficient hetero

atom:.Wolf, Hofmann, Curtius, Losen, Schmidt, Beckmann rearrangement, Baeyer-Villiger

rearrangement, Stevens and Neber rearrangements.

UNIT-II 12 hours

Molecular orbital symmetry, frontier orbitals of ethylene, 1,3- Butadiene, 1,3,5- Hexatriene, allyl

system and 2,4-penta dienyl system, classification of pericyclic reactions, FMO approach,

Woodward- Hoffman correlation diagram method and perturbation of molecular (PMO) approach

for the explanation of Electrocyclic Reactions- Conrotatory and disrotatory motions (4n) and

(4n+2), cyclo addition reactions- Antarafacial and suprafacial additions, notation. of c

ycloadditions- (4n) and (4n+2) systems with a greater emphasis on (2+2) and (4+2) under thermal

and photochemical conditions.

UNIT-III 12 hours

FMO approach and perturbation of molecular (PMO) approach for the explanation of sigma tropic

rearrgements under thermal and photochemical conditions. suprafacial and antarafacial shifts of H

Sigmatropic shift involving carbon moieties, retention and inversion of configurations, (3.3) and

(5.5) sigmatropic rearrangements detailed treatment of Claisen , Cope rearrangements and aza-Cope

rearrangements.. fluxional tautomerism,

UNIT-IV 12 hiurs

Photo chemistry: Photochemical processes- Energy transfer, sensitization, Singlet and triple

states and their reactivity. Photo reactions of carbonyl compounds, enes, dienes, and Aromatic

compounds–isomerisation–additions. Photochemistry of carbonyl compounds – Norrish type I and

II reactions –Paterno – Buchi Reaction. Photo reduction, Photochemical rearrangements – Photo

Fries rearrangement, Di-π- methane rearrangement.

UNIT-V 12 hours

Nanochemistry : Introduction, carbon nano tubes: structure of single and multi-walled carbon

nano tubes, synthesis-solid and gaseous carbon source-based production techniques, synthesis with

controlled orientation. Growth mechanism of carbon nano tubes-catalyst free growth, catalyst

activated growth, properties-general, adsorption, electronic & optical, mechanical and reactivity.

Applications.

SUGGESTED BOOKS:

1.Mechanism and structure in Organic Chemistry “ E.S.Gould Henry – Holt and Co, Newyork

2.Advances in Organic Reaction mechanism and structure J. March (McGrew Hill)

3.Aguide Book to Mechanism in Organic Chemistry” by P.Sykes

4.Synthetic approaches in organic chemistry by R.K.Bansal(Narosa Publications)

5.Some modern methods of synthesis by Carruthers ( Cambridge).

6. G.A.Ozin, A.C. Arsenault Nano chemistry, RSC.

7. Diwan, Bharadwaj, Nanocomposites, Pentagon. 8. V.S.MuralidharanA.Subramania, Nanoscience

and Technology, Ane Books.



Paper: Organic Reaction Mechanisms And Nanochemistry Semester: IV


UNIT - I

1. a) Write a note on Pinacol – Prinacolone Rearrangement? (6M)

b) Explain the following rearrangements? (8M)

1. Wagner – Meerwein rearrangement?

2. Benzil – Benzilic and rearrangement?

3. Baeyer – Villiger rearrangement?

Or

2. a) Wagner – Meerwin rearrangement? (6M)

b) 1. Beckmann rearrangement (8M)

2. Stevens rearrangement

3. Neber rearrangement

UNIT –II

3. a) Write the molecular orbitals of 1,3 butadiene1,3,5 Hexatriene? (6M)

b) Write the correlation diagrams for unit 2 electro cyclic reactions? (8M)

Or

4. a) Define antrafacial & superficial addition with neat Diagrams? (6M)

b) Write FMO approach for 2+2 cycle additions? (8M)

UNIT – III

5. a) Define sigmatropic rearrangements & It‟s classification? (6M)

b)Explian sigmatropic rearrangement involving Hydrogen atom by PMO method? (8M)

Or

6. a) Write a note on cope & Aza cope rearrangements? (6M)

b) Explain (3,3) sigmatropic rearrangements involving carbon moiety using FMO approach?

(8M)

UNIT – IV

7. a) Write the photo chemistry & Dienes? (8M)

b) Explain the reactivity singlet and triplet states? (6M)

Or

1. a) Explain Norrish type I and type II reactions with examples? (8M)

b) Write about Di-π-Methane rearrangement? (6M)

UNIT-V

2. a) Write a brief note on structure of single and Multiwalled carbon nanotubes?

(8M)

b) Write a brief note on catalyst activated growth with suitable examples? (6M)

Or

3. Discuss the properties of carbon nanotubes? (8M)

4. Discuss the synthesis with controlled orientation? (6M)

Question Bank


Paper: Organic Reaction Mechanisms And Nanochemistry Semester: IV

UNIT-1

1. Explain the mechanism involved in Pinacol pinacolone rearrangement.

2. Write the mechanism of Wagner Meerwein rearrangement.

3. Write a note on Benzil-Benzilic acid rearrangement and Favorski rearrangement.

4. Write the mechanism involved in Hofmann, Curtius reartrangements.

5. Write the synthetic importance of Baeyer-Villiger rearrangement.

6. Define Beckmann rearrangement.

7. Explain Curtius, Losen, Schmidt rearrangements.

UNIT-II

1. Define and classify the pericyclic reactions.

2. Write the molecular orbitals of 1,3 –butadiene and 1,3,5-hexatriene.

3. Describe con rotation and dis rotation with neat diagrams.

4. Explain the 4n+2 electrocyclic reactions by FMO approach.

5. Explain the 2+2 cyclo additions by PMO approach.

6. Define antarafacial and suprafacial additions.

7. Write the orbital symmetry correlational digrams for 4+2 cycloadditions.

UNIT-III

1. Define sigmatropic rearrangement a d write their classifications.

2. Write about suprafacial and antarafacial shifts of H.

3. Write a note on Sigmatropic shift involving carbon moieties.

4. Explain claisen rearrangement.

5. Write a note on Cope rearrangements and aza-Cope rearrangements.

6. Explain fluxional tautomerism.

UNIT-IV

1. Explain the reactivity of singlet and triplet states.

2. Write the photochemistry of dienes.

3. Explain Norrish type-1 and 2 reactions.

4. Write the photochemistry of carbonyl compounds.

5. Write the mechanism of Di-pi methane rearrangement.

6. Write the photochemistry of Aromatic compounds.

7. Define energy transfer process and photo sensitization.

UNIT-V

1. Write the synthesis of single and multi-walled carbon nano tubes.

2. Write a note on solid and gaseous carbon source-based production techniques.

3. Explain Growth mechanism of carbon nano tubes.

4. Write adsorption, electronic & optical, mechanical properties of carbon nano tubes.

5. Write the applications of carbon nano tubes.

6. Explain the structure of single and multi-walled carbon nano tubes




II M.Sc IV Techniques and Tools for

Industrial Applications

OCH40317 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

4 4 0 30 70

Course Objectives

Define the concepts of equilibrium stages and unit operations

Explain what is meant by phase equilibrium

Explain the basic concepts of mass transfer

List the steps in the structured problem-solving approach and start to use this approach

Have some familiarity with the prerequisites

Learning Outcomes


To develop an understanding of the range and theories of instrumental methods available in

analytical chemistry

To develop knowledge pertaining to the appropriate selection of instruments for the

successful analysis of complex mixtures

To develop an understanding of the role of the chemist in measurement and problem solving

in chemical analysis

To provide an understanding of and skills in advanced methods of separation and analysis

To provide practical experience in selected instrumental methods of analysis.

PAPER – III Techniques and Tools for Industrial Applications Code: OCH40317

UNIT–I 12 hours

Introduction to Chromatography and its Classification:

Column Chromatography: Principle, stationary phase , mobile phase, Packing of column,

advantages, dis-advantages and applications.

Paper Chromatography: Basic principle, Types of paper Chromatography- ascending,

descending, Radial and two dimensional paper chromatography, location of spots and measurement

of Rf values, Development of chromatograms - Visualization methods, and applications of paper

chromatography – separation of amino acids by paper chromatography

UNIT–II 12 hours

Thin Layer Chromatography: Basic principle, choice of adsorbents and choice of solvents,

preparation and development of TLC plates, Visualization methods, measurement of Rf values and

applications of TLC.

Ion exchange Chromatography: Basic Principles. Preparation of cross linked polystyrene

resins. Different types of cation and anoin exchange resins. Application in the purification of

carboxylic acids and amines.

UNIT – III 12 hours

High Performance liquid chromatography(HPLC): Basic Principles. Normal and reversed

Phases. Selection of column and mobile phase. Instrumentation. Detectors; RT values. Applications

in the separation, identification and quantitative estimation of organic compounds. Method

Development and validation parameters of HPLC.

UNIT-IV 12 hours

Gas Chromatography: Theory and principle of Gas liquid chromatography, Selection of columns

and carrier gases. Instrumentation, Detectors-Thermal Conductivity detectors, flame ionisation

detectors, flame photometric detectors and electron capture detectors, factors effecting separation,

RT values. Applications in the separation, identification and quantitative analysis of organic

compounds-Amino acids and hydrocarbons.

UNIT–V 12 hours

Electrophoresis: Basic Principles. Capillary electrophoresis. Instrumentation, zone-

electrophoresis, gel-electrophoresis, Immuno electrophoresis, Paper electrophoresis and separation

serum proteins by paper electrophoresis, Applications.

SUGGESTED BOOKS:

Principles of Instrumental Analysis by D.A.Skoog, F.J.Holler and T.A.Nieman, Harcourt College

Pub.

2.Separation Techniques by M.N.Sastri, Himalaya Publishing House (HPH), Mumbai.

3.Bio Physical Chemistry by A.Upadhyay, K.Upadhyay and N.Nath, (HPH) , Mumbai.

4. A Hand Book of Instrumental Techniques for Analytical Chemistry-Ed-F.A.Settle, Prearson Edn

Delhi.27

5. Introduction to Organic Laboratory Techniques-D.L.Pavia,G.M.

Lampman,G.S.Kriz and R.G.Engel,Saunders College Pub (NY).

6. Instrumental methods of Chemical Analysis by B.K.Sharma, Goel Publish House, Meerut.

7. Instrumental methods of Chemical Analysis by H.Kaur, Pragati

Prakasan, Meerut.

8. Protein Purification-Principles and practice, IIIEdn-R.K.Scopes, Narosa Publishing House.



Paper: Techniques and Tools for Industrial Applications Code: OCH40317


UNIT - I

1. Describe the principle, theory and applications of column chromatography?

(14M)

OR

2. a) Describe the principle of Ion exchange chromatography? (7M)

b)Write the preparation of class linked polystyrenes? (7M)

UNIT- II

3. a) Write the basic principle and types of paper chromatography? (8M)

b) Write the applications of paper chromatography? (6M)

Or

4. a write about basic principle, choice of adsorbents, choice of solvents and

preparations and development of TLC? (14M)

UNIT - III

5. a) Write about basic principal and types of HPLC? (8M)

b)Write a note on detectors used in HPLC? (6M)

Or

6. a) Explain the instrumentation of HPLC? (8M)

b)Write a note on method development and validation parameters? (6M)

UNIT – IV

7. a) Write the theory and principle of gas Liquid chromatography? (8M)

b) Write a note on selection of columns and carrier gases? (6M)

Or

8. a) Explain the instrumentation of G.C.? (8M)

b) Explain the applications of G.C.? (6M)

UNIT – V

9. Write the basic principal of capillary electrophoresis? (14M)

Or

10. Write the principle of paper electophoresis and separation of serum

proteins by paper electrophoresis? (14M)

Question Bank


Paper: Techniques and Tools for Industrial Applications Code: OCH40317

UNIT-I

1. Write the principle involved in Column chromatography.

2. Write the applications of column chromatography.

3. Give a note on the basic principle involved in paper chromatography.

4. Write different types of paper chromatographic techniques.

5. Explain the visualization methods in paper chromatography.

6. Write the applications of paper chromatography.

7. Write a note on the packing of column.

UNIT-II

1. Write the basic principle involved in Thin layer chromatography.

2. Write a note on the preparation of TLC plates.

3. Write the applications of TLC.

4. Explain the Visualization methods in TLC.

5. Write a note on the development of TLC plates.

6. Write the basic principle of ion exchange chromatography.

7. Write the application of ion exchange chromatography in the purification of carboxylic

acids.

8. Write the application of ion exchange chromatography in the purification of amines.

UNIT-II

1. Write the principle involved in HPLC.

2. Explain the different detectors used in HPLC.

3. Explain the instrumentation of HPLC?

4. Write a note on method development and validation parameters?

5. Explain the instrumentation of HPLC?

6. Explain the applications of HPLC in the separation, identification and quantitative

estimation of organic compounds.

UNIT-IV

1. Write the different carrier gases used in GC.

2. Write a note on different types of detectors used in GC.

3. Explain the instrumentation of G.C.?

4. Write the applications of GC in the identification of amino acids.

5. Write a note on Rt values.

6. Write the principle involved in GC.

UNIT–V

1. Write the principle involved in electrophoresis.

2. Explain about capillary electrophoresis.

3. Write a note on immune electrophoresis.

4. Describe paper electrophoresis.

5. Write the procedure for the separation of serum by using paper electrophoresis.


II M.Sc IV Project work OCH40517 2017-18

Syllabus

Total No of Hours

for Teaching -

Learning

Instructional Hours

for Week

Duration of

Semester End

Examination in

Hours

Max Marks Credits


3 Hours CIA SEE

8 - - 60 140

Course Objectives

Developing students as successful professionals.

Developing students as effective researchers.

Maintaining and enhancing the overall quality of the program.

Outcomes

Students should have an advanced level understanding of Analytical, Inorganic, Organic,

and Physical Chemistry.

Students should be able to communicate the results of their scientific research in writing and

in oral presentation.

Students should acquire the tools to become fully independent chemical researchers. They

should be able to synthesize advanced material from the different areas of chemistry and

formulate and carry out a research project that can lead to publication(s) in a refereed

journal.

Documents

Course Objectives: Outcomeskbncollege.info/attachments/mscch.pdfI M.Sc I General Chemistry OCH10117 2017-18 Syllabus Total No of Hours for Teaching - Learning Instructional Hours for