Copies of NMR and HRMS spectra Yb(OTf)3 mediated MCR: a ... · Copies of NMR and HRMS spectra Yb(OTf)3 mediated MCR: a new and regioselective approach towards polysubstituted pyrroles

1

Copies of NMR and HRMS spectra

Yb(OTf)3 mediated MCR: a new and regioselective approach

towards polysubstituted pyrroles of pharmacological interest

G. Rajeshwar Reddy,a,b T. Ram Reddy,a Suju C. Joseph,a K. Sateesh Reddy,a Chandana Lakshmi

T. Meda,c Ajit Kandale,c D. Rambabu,c G. Rama Krishna,d C. Malla Reddy,d Kishore V.L.Parsa,c

K. Shiva Kumar,c and Manojit Pal*,c

aCustom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Bollaram Road Miyapur,

Hyderabad 500 049, India bChemistry Division, Institute of Science and Technology, JNT University, Kukatpally,

Hyderabad 500072, Andhra Pradesh, India cInstitute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500046,

India. dDepartment of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata,

West Bengal, 741252, India.

E-mail: [email protected]

Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

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4a 1H NMR (400 MHz, CDCl3)


3

4a 1H NMR (100 MHz, CDCl3) Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

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4a HRMS


5

NO

4a HRMS


6

4b 1H NMR (400 MHz, CDCl3)


7

4b 1H NMR (100 MHz, CDCl3)


8

NO

Cl

4b HRMS


9

NO

Cl

4b HRMS


10

4c 1H NMR (400 MHz, CDCl3)

N

O

Br


11

4c 13C NMR (100 MHz, CDCl3)

N

O

Br


12

4c HRMS

N

O

Br


13

4c HRMS

N

O

Br


14

4d 1H NMR (400 MHz, CDCl3)

NO

Br


15

NO

Br

4d 13C NMR (100 MHz, CDCl3) Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

16

NO

Br

4d HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

17

NO

Br

4d HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

18

4e 1H NMR (400 MHz, CDCl3)

NO

F

Br


19

4e 13C NMR (100 MHz, CDCl3)

NO

F

Br


20

NO

F

Br

4e HRMS


21

4c 1H NMR (100 MHz, CDCl3)

4e HRMS

NO

F

Br


22

NO

O

4f 1H NMR (400 MHz, CDCl3)


23

NO

O

4f 13C NMR (100 MHz, CDCl3)


24

4f HRMS

NO

O


25

NO

O

4f HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

26

4g 1H NMR (400 MHz, CDCl3)

N

O

OCH3


27

4g 13C NMR (100 MHz, CDCl3)

N

O

OCH3


28

4g HRMS

N

O

OCH3


29

4g HRMS

N

O

OCH3


30

4h 1H NMR (400 MHz, CDCl3)

N

O

OCH3

OCH3


31

4h 13C NMR (100 MHz, CDCl3)

N

O

OCH3

OCH3


32

4h HRMS

N

O

OCH3

OCH3


33

4h HRMS

N

O

OCH3

OCH3


34

4i 1H NMR (400 MHz, CDCl3)

N

O

NO2


35

4i 13C NMR (100 MHz, CDCl3)

N

O

NO2


36

4i HRMS

N

O

NO2


37

4i HRMS

N

O

NO2


38

4j 1H NMR (400 MHz, CDCl3)

N

O

OH


39

4j 13C NMR (100 MHz, CDCl3)

N

O

OH


40

4j HRMS

N

O

OH


41

4j HRMS

N

O

OH


42

N

O

4k 1H NMR (400 MHz, CDCl3)


43

N

O

N

O

4k 13C NMR (100 MHz, CDCl3)


44

N

O

4k HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

45

N

O

4k HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

46

4l 1H NMR (400 MHz, CDCl3)

N

O


47

4l 1H NMR (100 MHz, CDCl3)

N

O


48

4l HRMS

N

O


49

4l HRMS

N

O


50

4m 1H NMR (400 MHz, CDCl3)

N

O

ClCl


51

4m 1H NMR (100 MHz, CDCl3)

N

O

ClCl


52

4m HRMS

N

O

ClCl


53

N

O

ClCl

4m HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

54

4n 1H NMR (400 MHz, CDCl3)

N

O


55

4n 1H NMR (100 MHz, CDCl3)

N

O


56

4n HRMS

N

O


57

4n HRMS

N

O


58

N

O

OH

4o 1H NMR (400 MHz, CDCl3)


59

N

O

OH

4o 1H NMR (100 MHz, CDCl3) Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

60

N

O

OH

4o HRMS


61

N

O

OH

4o HRMS Electronic Supplementary Material (ESI) for RSC AdvancesThis journal is © The Royal Society of Chemistry 2012

62


Documents

Copies of NMR and HRMS spectra Yb(OTf)3 mediated MCR: a ... · Copies of NMR and HRMS spectra Yb(OTf)3 mediated MCR: a new and regioselective approach towards polysubstituted pyrroles