CoolLine - Brooks Life Sciences · Cold Chain Solutions Sample Storage, Lab Services & Transport Automated Storage Systems Informatics & Technical Solutions ... cooling all the way

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Cryopreservation & Cold Chain Solutions

Sample Storage, Lab Services & Transport

Automated Storage Systems

Informatics &Technical Solutions

Sample Consumables& Instruments

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ORDERING INFORMATION For ordering information please contact your local Brooks Life Sciences representative.


CoolCell® Controlled-Rate, Alcohol-Free Cell Freezing

CoolCell containers deliver a controlled and reproducible -1˚C/minute cell freezing rate to all vials when placed in a -80˚C freezer. CoolCell outperforms other methods of cell freezing including alcohol-filled containers (“Mr. Frosty”), wrapping tubes in paper towels or placing tubes in styrofoam boxes. CoolCell is the new standard for passive cell cryopreservation. Ideal for stem cells, cell lines, PBMC, primary cells, insect cells, nematodes, and many more.

Features:

M Consistent -1˚C/minute freezing rate

M No alcohol (or other disposable) needed

M Thermo-conductive core alloy regulates heat removal

M Precise engineering and materials ensure uniform cell freeze rate across all vials

Benefits:

M High reproducibility; identical freeze profiles every run

M High post-thaw cell viability; more live cells to use in your experiment

M No alcohol required; no ongoing expense, no maintenance, no variability

M No pre-cooling; use off the shelf

M Not cold to the touch when frozen

M Lid comes off easily after freezing

M Re-use for another freeze cycle after only 5 minute wait

M Selection of modules and colors

How It Works: The solid state core and technology of CoolCell containers precisely balances heat removal and air flow during the freezing period in the -80˚C freezer. This ensures reproducible, consistent cooling all the way to the storage temperature.


Competition:

M “Mr. Frosty” by Nalgene

M Styrofoam boxes, paper towels

M Expensive programmable freezers

Bundle with:

M CryoPod Carrier™ safe, simple, ergo transport

M TruCool® barcoded cryogenic vials

M TruCool hinged cryostorage boxes

M CryoCeps™ cryogenic vial grippers

CoolCell LX 12 vials 1.0 mL or 2.0 mL cryogenic vials Four colors

CoolCell FTS30 30 vials 1.0 mL or 2.0 mL cryogenic vials Four colors

CoolCell 5ml LX 12 vials 3.5 mL - 5.0 mL cryogenic vials Purple only

CoolCell SV2 and SV10 12 vials, 2.0 mL serum vials 6 vials, 10.0 mL serum vials Purple only

Target Customers:

M Cell culture

M Microbiology

M Virology

M CRO, CMO

M Biobanks, cell repositories

M Clinical labs


CoolBox™

All-Day, Ice-Free Cooling or Freezing

Features:

M Insulative outer material minimizes heat influx M Durable, reusable internal XT Cooling Core or XT Freezing

Core provides cooling source M Magnetic, inter-locking pieces ensure secure assembly and

easy sample access M Accommodates a variety of CoolRack and CoolSink modules M Clean with bleach or alcohol

Benefits:

M All day cooling (up to 16 hours) or freezing (up to 8 hours) with one Core

M No more trips to the ice machine; reduced risk of ice contamination

M Accommodates a wide array of sample tubes and plates

M Single or double-capacity workstations for a variety of applications 10 hour cooling with lid open

PROBLEM: Cooling samples on ice or in gel-filled coolers introduces temperature variability and the risk of contamination.

SOLUTION: CoolBox XT is an ice-free cooling workstation that provides 1-2oC temperature for up to 16 hours – without electricity or batteries. Place a CoolRack or CoolSink on the internal XT Cooling Core and keep samples cold all day. An optional XT Freezing Core allows bench top freezing for up to 8 hours.

Use on the bench, in a hood, or for short transport.


XT Starter, cooling platform

CoolBox™ XT (left) and CoolBox™ 2XT (right) portable, ice-free cooling or freezing workstations

XT Cooling Core (included)

CoolBox™ 30, ice-free cooling system

XT Freezing Core (optional)

How to build a CoolBox XT Workstation

1. Choose your sample module (CoolRack/CoolSink). What samples are you cooling – tubes or plates? How many samples need to be processed at one time?

2. Once you know your sample module(s), choose your CoolBox XT M CoolBox XT (BCS-502) holds one small tube module or one

plate module M CoolBox 2XT (BCS-503) holds two tube or plate

modules* See catalog or website for selection guide

Target Customers:

M EVERY LAB WITH AN ICE BUCKET! M Cell and tissue culture M Microbiology M Molecular biology M Genomics

Competition:

M Ice pans with ice M Gel-filled coolers such as IsoTherm (Eppendorf), Strata

Cooler (Stratagene) and LapTop Cooler (Nalge). NOTE: gel-filled coolers thaw from the outside toward the center, introducing temperature variability between outer and inner wells

Bundle with:

M CoolRack® tube holders M CoolSink® plate modules M TruCool® cryogenic vials M TruCool hinged cryostorage boxes

M Proteomics M CROs, CMOs M Biobanks M Clinical


Features:

M Use on ice, dry ice, liquid nitrogen or heat sources. Modules rapidly adapt to temperature source.

M Temperature range: -196°C through > 100°C

M +/- 0.1°C well-to-well uniformity

M Hard-anodized surface for resistance to rust, corrosion, and abrasion

M Autoclavable. Or sterilize via high-heat, bleach solutions, disinfectants or alcohol.

M Automation-friendly (SBS compatible) modules available

Benefits:

M Keeps tube samples at desired temperature

M Keeps samples dry, upright and organized

M Minimizes risk of contamination

M Eliminates variability in sample cooling, freezing, thawing

M Converts ice bucket into a reproducible cooling source

CoolRack ® Thermo-Conductive Tube Modules

PROBLEM Current method of cooling samples in ice. The random layout can result in mis-identification, errors in processing and temperature variability.

SOLUTION CoolRack modules ensure consistent temperature to all samples (+/- 0.1°C), stability and organization; making ice bucket cooling reproducible.

How It Works: Heat is removed from samples during cooling (A) and heat is applied to samples when warming (B). Through precision engineering, CoolRack alloy uniformly distributes and maintains temperature across all samples.

A B Cooling Warming


Bundles with:

M TruCool® cryogenic vials

M TruCool ice pans and buckets

M CoolBox™ ice-free cooling workstations

M ThermalTray™ platforms for supporting modules in liquid temperature sources

CoolRack® tube modules accommodate a wide variety of tubes and capacities. Use on cooling sources such as ice, dry ice, liquid nitrogen, refrigerator or freezer, or heating sources such as water bath, hot plate, incubator, oven.

Target Customers: Competition:

M Ice!

M Problems with ice include: unorganized samples, variable temperature, wet samples, soggy labels, contamination, repeated trips to ice machine.

M Academic

M Pharma

M BioTech

M CRO, CMO

M Biobank

M Clinical

M EVERY LAB WITH AN ICE BUCKET!


PROBLEM (Graph A) A 96-well plate resting directly on ice has uneven well-to-well cooling. Importantly, none of the wells are below 4°C.

SOLUTION (Graph B and photo) Using a CoolSink® module to hold

the plate on ice ensures a more even temperature distribution and all wells are below 4°C.

Features:

M Use on ice, dry ice, liquid nitrogen or heat sources. Modules rapidly adapt to temperature source.

M Hard-anodized surface for resistance to rust, corrosion, and abrasion

M Autoclavable. Or sterilize via high-heat, bleach solutions, disinfectants or alcohol.

M Automation-friendly (SBS- compatible) modules available

Benefits:

M All wells at desired temperature while also keeping plate dry and sterile by eliminating contact with ice and water

M Eliminates well-to-well temperature variability in cooling, freezing, thawing; assay to assay, person to person, lab to lab, site to site

M Makes ice bucket a reproducible cooling source

CoolSink ® Thermo-Conductive Plate Modules

How It Works: Heat is removed from samples during cooling (A) and heat is applied to samples when warming (B). Through precision engineering, CoolSink alloy uniformly distributes and maintains temperature across all samples.

A B Cooling Warming


Competition:

M Ice!

M Problems with ice include: unorganized samples, variable temperature, wet samples, soggy labels, contamination, repeated trips to ice machine.

Companion Products:

M TruCool® Ice pans and buckets

M CoolBox™ ice-free plate cooling workstations

Target Customers:

M Academic

M Pharma

M BioTech

M CRO

M Biobank

M Clinical

M EVERY LAB WITH AN ICE BUCKET!

CoolSink® plate modules accommodate a variety of plates including 6-, 12-, 24-, 48-well plates, 96-well flat bottom plates, 96-well round-bottom plates and reagent reservoirs. SBS- compliant modules available.


Accessories

TruCool® Barcoded Cryogenic Vials

TruCool leak-proof, auto-cap cryogenic vials are ideal for cell culture and biobanking. The screw cap features a co-molded thermally-fused gasket which prevents leaking, slipping and risk of contamination. The gasket is 95kPa certified to provide a leak-proof seal. The star socket on cap top is compatible with auto-decapping equipment. Each vial is individually barcoded with a unique identifier that can be read with common barcode readers. Recommended for use in vapor phase liquid nitrogen.

TruCool® Hinged CryoBoxes

M Patented hinge design ensures lid stays connected to the base in the correct orientation to keep samples and markings in synch

M Plastic 81-place or 100-place grid; 2-inch or 3.5-inch height format

M Laminated cardboard - water-resistant and durable

M 2-inch cryoboxes available in 6 colors, 5 or 50 per pack

M 3.5-inch cryoboxes available in 2 colors, 6 or 30 per packs


TruCool® Ice Buckets and PansRecyclable, non-toxic ethylene-vinyl acetate (EVA) containers for multi-purpose use with ice, dry ice or liquid nitrogen. 5 sizes, 7 colors.

CoolProbe™Traceable temperature monitor for accurate temperature monitoring of samples while in CoolRack® or CoolSink® modules.

TruCool® Cryogenic Vial Locking RacksCryogenic vial locking racks feature a locking mechanism that allow one-hand opening for self-standing cryogenic vials. Accommodates both round bottom and self-standing vial formats. Racks have A – J and 1 – 5 row and column indexing for easy organization. Autoclavable.

CryoCeps™ Cryogenic Vial Grippers Cryogenic vial grippers feature a unique design to grasp internal- or external-thread cryogenic vials. Easily sort or move vials while maintaining sterility and protecting fingers from frozen vials, dry ice and liquid nitrogen.

Accessories

Documents

CoolLine - Brooks Life Sciences · Cold Chain Solutions Sample Storage, Lab Services & Transport Automated Storage Systems Informatics & Technical Solutions ... cooling all the way