CONVENTIONAL CANCER THERAPIES

Halsted’s Radical Mastectomy vs ‘Lumpectomy’

3-D structure & schematic of p-glycoprotein

Examples: Methotrexate Eg. Doxorubicin Eg. Cyclophosphoramide, Melphalan

Eg. Vinblastine, paclitaxel

Newer Approaches to Cancer Therapy

Incorporate Predictive Diagnosis

Are Mechanism Based

Designed for Selectivity

Figure 16.2 The Biology of Cancer (© Garland Science 2007)

Figure 16.4a The Biology of Cancer (© Garland Science 2007)

Figure 16.4b The Biology of Cancer (© Garland Science 2007)

Figure 16.5a The Biology of Cancer (© Garland Science 2007)

Figure 16.5b The Biology of Cancer (© Garland Science 2007)

Figure 16.5c The Biology of Cancer (© Garland Science 2007)

Figure 16.5d The Biology of Cancer (© Garland Science 2007)

Therapies Targeting nonTumor Cells

Table 13.3 The Biology of Cancer (© Garland Science 2007)

Targeting the Angiogenic Switch

Tsp-1 Expression Induced by p53

Tsp-1 Expression Inhibited by Ras

An Intrinsic Negative Regulator of Endothelial Cell Populations

VEGF-

R

Inhib

.

PDGF-R

Inhib

.

Synergistic Inhibition of Angiogenesis by the Combination of a Pericyte Inhibitor and an Endothelial Cell Inhibitor

Figure 13.48a, b The Biology of Cancer (© Garland Science 2007)

Radiation Can Have a Greater Effect on Cells of the Microvasculature Than on Tumor Cells

Bone marrow origin of microvasculature cells

Figure 13.49 The Biology of Cancer (© Garland Science 2007)