Controlled Release Society

3344thth AAnnnnuuaall MMeeeettiinngg aanndd

EExxppoossiittiioonn ooff tthhee CCoonnttrroolllleedd RReelleeaassee SSoocciieettyy

22000077

July 7-11, 2007 Long Beach, California, USA

Volume 1 of 3

Printed from e-media with permission by:

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Red Hook, NY 12571 www.proceedings.com

ISBN: 978-1-60560-035-2

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Copyright Copyright© 2007 by the Controlled Release Society All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior permission of the publisher. The contents of this CD may not be served via a network without prior permission of the publisher. Controlled Release Society 3340 Pilot Knob Road St. Paul, MN 55121 USA

Phone: +1.651.454.7250 Fax: +1.651.454.0766 Email: crs@scisoc.org

Controlled Release Society

34th Annual Meeting and Exposition of the Controlled Release Society 2007

TABLE OF CONTENTS

Volume 1

Non-Canonical Amino Acids in Protein Design, Evolution and Analysis ..................................... 1

David Tirrell

Improved Childhood Vaccines – A Grand Challenge in Global Health ......................................... 2Stevem Buchsbaum

Cell Sheet Tissue Engineering and Their Clinical Applications .................................................... 3Teruo Okano

Engineered Drug Therapies via Lithographic Processes from the Electronics Industry ................................................................................................................................................ 5

Joseph DeSimone

The Role of Biomarkers and Biologically Interactive Delivery Systems (receptor mediated transcytosis) in the Future of Chemotherapy ................................................................. 6

Patrick Soon-Shiong

Advances in Peptide and Protein Delivery ....................................................................................... 7Edith Mathiowitz

Preparation and Characterization of Polyethylene Glycol-Modified TNF-Related Apoptosis Inducing Ligand (TRAIL).................................................................................................. 8

Cheng-Hao Jin

Clinical Trial of Recombinant Human PH20 Hyaluronidase’s Effect on Subcutaneous Absorption and Pharmacokinetics of a Large Protein Molecule Therapeutic ........................................................................................................................................ 10

Richard Yocum

Self-assembled Green Tea-nanocomplex Which Achieves Synergistic Effects ........................ 12Joo Eun Chung

MRI Contrast Enhanced Polyelectrolyte Complexes for Traceable VEGF Delivery................... 14Cory Berkland

Polymeric Micelles for Combination Drug Delivery ...................................................................... 16Glen Kwon

Poly (Ethylene Oxide)-Poly(e-caprolactone) Micelles in Different Morphologies: Advantages of Worm-like Micelles for Delivery of Paclitaxel in Lung Cancer Therapy .............................................................................................................................................. 18

Shenshen Cai

Temperature-Controlled Intracellular Localization of Thermoresponsive Polymeric Micelles ............................................................................................................................ 20

Jun Akimoto

Heparin-Immobilized Microparticles for Sustained Drug Delivery .............................................. 22Cristianne Rijcken

pH-Responsive Elastin-Like Polypeptides (ELPs) for Low pH-induced Drug Release ............. 24Daniel Callahan

Plasma Generated Polymer Films for Drug Delivery Applications .............................................. 26Richard Timmons

Control Release of Biocide Incorporated Drawn Polymers: Molecular Orientation or/and Dispersion? ........................................................................................................................... 28

George Voyiatzis

Effect of Different Plasticizers on the Storage Stability of Enteric-coated Soft Gelatine Capsules ............................................................................................................................. 30

Fuerst Thomas

Monitoring a Cross-Linked Hydrogel Reaction By FT-NIR Spectroscopy .................................. 32Paul McDonald

Application of Multivariate Analysis in Understanding Polymorphic Transformation Models .................................................................................................................... 34

Thomas Rades

In Situ Gelling Biodegradable Polymers - Intratumoral Delivery of Paclitaxel ........................... 36Abraham Domb

Synthesis of Degradable Linear Poly(ethylene glycol) a+B52s Multifunctional Drug Delivery Carriers ...................................................................................................................... 39

Youqing Shen

Self-Expandable Polymeric Stents with a Shape-Memory Property............................................ 41Hsing-Wen Sung

In Vitro Differentiation of Mouse Embryonic Stem Cells Into Pancreatic Insulin Producing Cells Using Three-Dimensional Alginate Scaffolds ................................................... 43

Nan WANG

Characterization of Charged Hydrogels for Nerve Regeneration ................................................ 45Mahrokh Dadsetan

Blood-Brain Barrier Delivery with Molecular Trojan Horses ........................................................ 47William Pardridge

Understanding Endocytic Pathways Towards Improved Intracellular Delivery and Targeting of Therapeutic Macromolecules..................................................................................... 49

Arwyn Jones

The Role of Apolipoproteins in Nanoparticle-Mediated Transport of Drugs into the Brain ................................................................................................................................................... 51

Joerg Kreuter

Controlled Cellular Delivery of Bcr-Abl Coiled-Coil Domain for Apoptosis of Chronic Myelogenous Leukemia Cells ........................................................................................... 53

Carol Lim

Biodegradable Polyesters as Excipients for Controlled Release Products ............................... 55John Gibson

Protein Formulation for Injectable Drug Delivery Systems .......................................................... 56Franklin Okumu

Multifunctionality – Novel Set of Requirements towards Pharmaceutical Nanocarriers ...................................................................................................................................... 57

Vladimir Torchilin

The Interface Between Intellectual Property Rights and the Legal Framework of the Pharmaceutical Regulatory Process ........................................................................................ 58

Anne-Marie Lademann

Human Versus Veterinary Species Comparison in GI Physiology .............................................. 59Kazuko Sagawa

Accidental Gastroretention .............................................................................................................. 60Clive Wilson

Gastro-retention – Large (Ruminant) Animals Versus Human..................................................... 62Keith Ellis

In Vivo and In Vitro Factors Influencing the Performance of Parenteral Controlled Release Systems............................................................................................................................... 64

Marilyn Martinez

Building New Vaccines against TB ................................................................................................. 66Yvonne Perrie

Liposaccharides in Vaccine Delivery.............................................................................................. 68Istvan Toth

Novel N-trimethyl Chitosan - Poly ((?-glutamic acid) Nanoparticles for Mucosal Delivery of Vaccines ......................................................................................................................... 70

H. Oya Alpar

Adsorption of Protein Antigens onto PLG Microparticles Studied by X-ray Photoelectron Spectroscopy (XPS) and Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) ................................................................................................................. 72

Andrew Parker

Comparison of Immunogenicity of Sustained Release Implants Containing Imiquimod, A-galactosylceramide or Quil-A .................................................................................. 74

Julia Myschik

Formation And Stability Of Biopolyelectrolyte Multilayers and their Potential Use for the Encapsulation and Controlled Release of Active Ingredients From Foods ................... 76

Roger Parker

Flavour Encapsulation into Yeast Cells and Cooking Stability in Aqueous Food Products .... 78Emmanuel Heinrich

Innovative Microencapsulation and Release Technology for Accelerating Cheese Ripening ............................................................................................................................................. 80

Kasipathy Kailasapathy

Microspheres Based on Soy, Zein Protein as Oral Delivery Vehicles. In Vitro Study with a Dynamic Artificial Digestive System ........................................................................ 82

Lingyun Chen

Tailoring Efficacy by Choosing the Appropriate Encapsulation Technology ............................ 84Fanny Weinbreck

Safety Considerations Associated with Veterinary Parenteral Controlled Release Systems ............................................................................................................................................. 86

Marilyn Martinez

Quality Attributes Influencing the Performance of Parenteral Controlled Release Systems ............................................................................................................................................. 88

Mai Huynh

CRS Industrial Session: Positioning for a Liquidity Event.......................................................... 90Debra Bingham

Biodegradable Macromolecular MRI Contrast Agents.................................................................. 91Zheng-Rong Lu

Imaging Molecular Processes by Optical Methods ....................................................................... 92Samuel Achilefu

Monitoring Drug Delivery and Tissue Engineering by ESR and NMR Spectroscopy and Imaging ....................................................................................................................................... 94

Karsten Maeder

In Vivo Applications of “Sensing” Imaging Agents ...................................................................... 96Alexei Bogdanov

Bio-inspired Nanomaterials for Tissue Regeneration and Sensing ............................................ 97Molly Stevens

Surface and Nano-environmental Influences Induced by Polymer-based Nanoparticles on Skin Penetration of a Lipoidic Drug.................................................................. 98

Marc Schneider

Gold Nanorods as a Photosensitizer for Photothermal Therapy ............................................... 100Takuro Niidome

Nanofabricated Particles for Engineered Drug Therapies: A Preliminary Biodistribution Study of PRINTTM Nanoparticles ....................................................................... 102

Stephanie Gratton

Intracellular Uptake of Silica-Iron Oxide Nanotubes ................................................................... 104Anajn Nan

Supramolecular Polyrotaxanes for Drug Delivery....................................................................... 106Nobuhiko Yui

Polyarginine Segments in Block Copolypeptides Drive Vesicular Formation and Cellular Entry ................................................................................................................................... 108

Victor Sun

Well-defined Diblock Copolymers Synthesized by Atom Transfer Radical Polymerization for Gene Delivery.................................................................................................. 110

Chun Wang

PEHAM Dendrimers for Drug Delivery Applications ................................................................... 112Sonke Svenson

Cyclic Polymers as Scaffolds for Drug Delivery.......................................................................... 114Scott Grayson

Theragnostic Imaging of Tumors by Delivery Carriers............................................................... 116Ick Chan Kwon

Coenzyme Q10-Loaded Liposomes Effectively Protect the Myocardium in Rabbits with Experimental Myocardial Infarction ...................................................................................... 118

Tatyana Levchenko

A Cationic Liposomal Dosage Form of Methotrexate for Specific Delivery to Inflamed Tissue in RA..................................................................................................................... 120

Michael Rankl

In-vitro Model for the Investigation of Drug Delivery Systems Direct from Nose-to-Brain via Olfactory Epithelium....................................................................................................... 122

Alpesh Mistry

Particles Delivered via Non-degradative Pathway Spend More Time Near Cell Nucleus ............................................................................................................................................ 124

Kaoru Hida

Canine Pharmacogenetics ............................................................................................................. 126Katrina Mealey

A Single Artificial Insemination in Sows with Semen Controlled Release Capsules .............. 128Marco Klinger

Effect of Polyethylene Glycol on Release of Vitamin B12 from Ethylene-vinyl Acetate Copolymer Films ............................................................................................................... 130

Ian Tucker

In Vivo Studies with Streptococcus equi Antigens Encapsulated in Polymeric Nanospheres ................................................................................................................................... 132

Helena Florindo

Rheological and Micro-structural Characteristics of In-Situ Gelling Systems for Ocular Drug Delivery ...................................................................................................................... 134

Raid G. Alany

Diabetes Research: Obstacles and Opportunities ...................................................................... 136Aaron Kowalski, Julia Greenstein

Pharmacodynamic and Engineering Issues with Creating an Artificial Pancreas................... 138Bruce Buckingham

A Clinically Relevant Microcapsule for Islet Transplantation .................................................... 140C. Weber

Use of Encapsulated Islets to Treat Diabetes without Immunosuppression............................ 142David Scharp

Nanotechnology for Controlled Release: Putting the Market into Perspective........................ 143Marlene Bourne

Mesoporous Silica Nanoparticles with Stimulus-Controlled Drug Uptake and Release............................................................................................................................................. 144

David Oupicky

Biodegradable Planar Osmotic Pump for Long-term and Controlled Delivery of basic Fibroblast Growth Factor..................................................................................................... 146

WonHyoung Ryu

Evaluation of Mesoporous TCPSi, MCM-41, SBA-15 and TUD-1 Materials as Oral Drug Delivery Systems ................................................................................................................... 148

Teemu Heikkilä

Drug Eluting Nanostructured Coatings for Controlled Release ................................................ 150Ketul Popat

Systemic Delivery of siRNAs and Antagomirs: From Mice to Monkey, on the Way to Man............................................................................................................................................... 152

Muthiah Manoharan

Gene Delivery Systems Responding to the Cellular Signals (D-RECS ) for c-Src ................... 154Yuko Sato

Efficient Delivery of Antisense Oligo-Nucleotides In Vitro & In Vivo Using Degradable Polymersomes ............................................................................................................ 156

Younghoon Kim

Novel Non-Viral Targeted siRNA Delivery System ...................................................................... 158Chia-Ling Yang

Prevention and Reversal of Autoimmune Diabetes by PROMAXX Antisense Oligonucleotide Microspheres ...................................................................................................... 160

Larry Brown

Nanostructured Heparin Derivatives for Oral Delivery ............................................................... 162Youngro Byun

Improving Oral Delivery through the Use of Permeation Enhancers ........................................ 164Kathryn Whitehead

Oleyl Glycerate, a Structural Isomer of Monoolein, dramatically alters the Bioavailability of a Poorly Water Soluble Drug from Lipid-Based Liquid Crystalline Formulations in Rats................................................................................................... 166

Ben Boyd

Site-specific Drug Delivery to the Middle Region of the Small Intestine Reduces Food-drug Interactions That Cause Low Absorption of Drugs Taken after a Meal ................. 168

Shinji Sakuma

PAMAM Dendrimers: Surface Modification and Potential in Oral Delivery of SN-38............... 170Rohit Kolhatkar

Relationship Between the Structure of Polymeric Drugs and Their Accumulation and Intracellular Trafficking. What Do We Know About It? ........................................................ 172

Blanka Rihova

Polymer-Phloridzin Conjugates as an Anti-diabetic Drug that Inhibits Glucose Absorption through the Na+/Glucose Cotransporter (SGLT1) in the Small Intestine ........................................................................................................................................... 174

Yusuke Ikumi

A PEGylated Polymer-Photosensitizer Conjugate Containing Gd (III) for Site-Specific MRI-guided Photodynamic Therapy of Cancer ............................................................................ 176

Anagha Vaidya

Synthesis and Biological P+B2roperties of Folate-PEG-gemcitabine....................................... 178Fabiana Canal

Investigating the Cytotoxicity and Mechanism of Action of Dextrin-Phospholipase A2 Conjugates as Novel Anti-Tumour Agents ............................................................................ 180

Elaine Ferguson

Design and Selection of Extended Release Dosage Forms – An Industrial Perspective ...................................................................................................................................... 182

Ian Hardy

Development and Scale-up Considerations for Osmotic Drug Delivery Systems ................... 183Avinash Thombre

Quality by Design - Industrial Perspective ................................................................................... 184Nirdosh Jagota

Use of a Hierarchical Oxidative Stress Model to study NanoBio Interactions and Toxicity............................................................................................................................................. 185

Andre Nel

Mechanism of Oxidative Responsiveness in Polysulfide Nanoparticles.................................. 186Nicola Tirelli

Behavior of hMSC Cultured on Nanopatterned Surface ............................................................. 188Kam Leong

Biomimetic Hydrogels for Tissue Engineering and Regenerative Medicine ............................ 189Jennifer West

Nano-Scaled Layered Inorganic/Protein Hybrids and their Characterization in Biological Activity ........................................................................................................................... 191

Hsin-Cheng Chiu

BMP2 Immobilisation on Extracellular Matrices to Generate an Interactive Niche for Human Mesenchymal Stem Cells ............................................................................................ 193

Philipp Seib

Peritoneal Adhesion Prevention with an In situ Cross-linkable Hyaluronan Gel Containing Tissue-type Plasminogen Activator in a Rabbit Repeated Injury Model ............... 195

Yoon Yeo

Coating Adhesion and Cohesion Evaluation of Drug Eluting Stents........................................ 197Fuh-Wei Tang

Oral Drug Delivery with Polymeric Nanoparticles: a Mechanistic Approach ........................... 199Veronique Preat

Silicon Nanowires for Improved Intestinal Bioadhesion ............................................................ 201Kathleen Fischer

Hydrogel Filled Micro-engineered Particles for Oral Delivery of Chemotherapeutic Agents .............................................................................................................................................. 203

Sarah Tao

Efficient Oral Delivery of a Protein Pharmaceutical .................................................................... 205Randall Mrsny

Gastrointestinal Gene Delivery in Mice Using Polymeric Nanoparticles-in-Microsphere Oral System............................................................................................................... 207

Mayank Bhavsar

Novel Biomineral-binding Cyclodextrins for Controlled Drug Delivery in Oral Cavity............ 209Xin-Ming Liu

Preclinical Development of a Novel Antiinflammatory Peptide ................................................. 211David Friend

Added Product Complexities Demand Thoughtful Packaging: An Examination of What Packaging Can and Must Do for Medical Products ........................................................... 213

Laura Bix

Development of Inhaled Pulmonary Drug Products.................................................................... 215John Patton

Regulatory Issues in Obtaining Approval of Drug-Device Combination Products.................. 218George Baskinger

Probiotics: New Formulations And Controlled Release ............................................................. 219Helmut Viernstein

Applications of Novel Pregelatinized Starch As a Sustained Release Matrix Carrier .............................................................................................................................................. 221

Masaaki Endo

Application Development of EUDRAGIT®NM 30 D Diclofenac Sodium Matrix Tablet with Wet Granulation .......................................................................................................... 223

Henry Han

A New Application of Low-Substituted Hydroxypropyl Cellulose (L-HPC): Aqueous film coating for time-controlled released tablets and taste masking........................ 225

Naosuke Maruyama

Microcapsules for Multifunctional Industrial Coatings............................................................... 227James Oxley

Dendritic Cell Activation and Antigen Delivery by Cationic Lipids ........................................... 229Leaf Huang

Tumor-targeted Liposomes that Attack Tumor-associated Inflammation and Angiogenesis................................................................................................................................... 231

Raymond Schiffelers

Engineered Liposomes Containing Tunable Model-rafts: Basic Studies and Applications in Targeted Drug Delivery........................................................................................ 233

Stavroula Sofou

Design and Performance of Acid-Sensitive Liposomes Using Vinyl Ether Lipids with Tunable Reactivity .................................................................................................................. 234

David Thompson

Advances in Pulmonary Drug Delivery......................................................................................... 235Peter Byron

Optimisation of Deoxyibonuclease I (DNase I) Particles for Pulmonary Delivery ................... 237Rihab Ahmed

Effects of Cell Penetrating Peptides and Pegylation on Polyplex Size and Transfection Efficiency in Mouse Lungs ...................................................................................... 239

Juliane Nguyen

Lung Deposition and Pharmacokinetic of Tobramycin Dry Powder Formulations in Cystic Fibrosis ............................................................................................................................ 241

Gabrielle Pilcer

PROMAXX Microspheres for Pulmonary Delivery of Proteins and Peptides. Case Study : Human Growth Hormone .................................................................................................. 243

Julia E. Rashba-Step

A Surfactant-Based Glass Thermoplastic System (GTS) for Formulating Poorly Water-Soluble Weak Base Drug Candidates ................................................................................ 245

Marcus Brewster

Extended Release/High Drug Loaded Formulations Produced via Hot Melt Extrusion.......................................................................................................................................... 247

Mark Hall

Once a Day Therapy with Carvedilol Delivered in an Egalet ...................................................... 249Daniel Bar-Shalom

Evaluation of the Impact of Digestion on the in Vivo Performance of Two Lipid Based Oral Drug Delivery Systems............................................................................................... 251

Agnes Taillardat

Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended-Release Tablet Formulation of Levodopa-Carbidopa in Fed and Fasted Beagles ................................. 253

Peyman Moslemy

XELLEX™ Film Devices for Sublingual Administration of Lipid Lowering Drug Actives ...... 255Ulrich Westedt

Drug Delivery for Local Tumor Management: OncoGel® Clinical Experience ........................ 257Kirk Fowers

New Biodegradable “Smart” Hydrogels Containing Poly[(R)-3-hydroxybutyrate] for Sustained Protein Delivery....................................................................................................... 259

Xian Jun Loh

Optimizing the Formulation of Thermoresponsive Hydrogels by 1H-NMR Relaxometry..................................................................................................................................... 261

Hendrik Metz

Novel Injectable Hydrogel with a pH-Responsive Property Made of Hydrophobically-Modified Chitosan Derivatives ......................................................................... 263

Ya-Ling Chiu

Controlled Release of N-Acetylcysteine from Injectable Poly (DL-lactide-co-glycolide) Implants for AIDS Associated Kaposi's Sarcoma ....................................................................... 265

Kashappa Goud Desai

Tumor pH Responsive Nanosystems ........................................................................................... 267You Han Bae

Block Ionomer Complexes for Drug Delivery .............................................................................. 268Tatiana Bronich

Stimuli-Responsive Supramolecular Nanocarriers for Site-Directed Drug Delivery ............... 270Nobuhiro Nishiyama

Smart Polymeric Carriers for Biomolecular Therapeutics.......................................................... 272Patrick Stayton

Lipid Nanocapsules: A New Tool in Cancerology ...................................................................... 273Jean-Pierre Benoit

EPR Investigations on Dynamics of Distribution Processes and In Vivo Fate of Polymeric Nanocapsules ............................................................................................................... 275

Sandra Klein

Drugs Release from Gold Nanorods Embedded N-isopropylacrylamide Hydrogels............... 277Atsushi Shiotani

Lipid Coated Nanoparticles – Physicochemical Characterization, Cellular Adhesion and Cellular Uptake ....................................................................................................... 279

Johannes Sitterberg

Development and Characterization of Bone-Targeting Nanoparticles...................................... 281Stefanie Crumlett

Controlled Release of Actives in Skin .......................................................................................... 283Bozena Michniak

Effect of Hydroxycinnamic Acid, Magnesium Ascorbyl Phosphate and Hydroquinone on Tryptophan Levels in Human Skin ................................................................. 285

Nava Dayan

Encapsulation and Photoprotection of Vitamin E in a Starch-Oil Composite Emulsion System ............................................................................................................................ 287

John Wille

Lipophilic Moisturisers Interact with Stratum Corneum Intercellular Lipids............................ 289Joke Bouwstra

Topical NO Photorelease from Drug Delivery Development System ........................................ 291Renata Fonseca, Vianna Lopez

Tumor-Specific Targeting of Drug Delivery Systems for Cancer Therapy and Imaging ............................................................................................................................................ 293

Tamara Minko

Treatment of Colorectal Cancer Liver Metastases in CBA Mice by SMA-Pirarubicin Micelles and its Augmentation by Hyperbaric Oxygen ........................................... 295

Arun Iyer

Anti-angiogenic Actions of Liposomal Prednisolone Phosphate on Tumor-Associated Inflammatory Cells In Vivo......................................................................................... 297

Manuela Banciu

Low-dose TGF-ß Inhibitor Improves Cancer Therapy Using Nanocarriers for Intractable Solid Tumors ................................................................................................................ 299

Mitsunobu Kano

Microneedle Based Intradermal Delivery of Interleukin-12 in B16F10 Tumor Bearing Mice: Comparison with Subcutaneous and Intraperitoneal Therapy......................... 301

Alfred Harvey

Drug Transport in Retinal Pigment Epithelium – Key Player in the Blood – Retina - Barrier .............................................................................................................................................. 303

Arto Urtti

Slow-Releasing Tranilast in Polytetrafluoroethylene/Polylactide-co-glycolide Laminate Delays Adjustment after Strabismus Surgery in Rabbit Model................................. 304

Ji-Young Kim

Analysis of Subconjunctival Drug Delivery in the Eye Using Magnetic Resonance Imaging ............................................................................................................................................ 306

Stephanie Kim

Steam Sterilization of Cyclosporine Solid Lipid Nanoparticles: In-vitro Evaluation of Toxicity ........................................................................................................................................ 308

Evren H. Gokçe

Pharmacokinetic Modeling to Improve the Design of Intravitreal Corticosteroid Implants for Treating Macular Edema........................................................................................... 310

Susan Lee

Transdermal Drug Delivery: State of the Art and Future Challenges ........................................ 312Joke Bouwstra

In vivo and In vitro Transport of Active Ingredients into Murine Skin Using Deformable Nanoparticles ............................................................................................................. 314

Junoh Kim

Hydration Effects on Skin Microstructure and Implications to Enhanced Transcutaneous Delivery of Biomacromolecules ....................................................................... 316

Vijay John

Impact of Skin Metabolism and Vehicle Effect on Permeation in Skin Models ........................ 318Simone Lombardi Borgia

Arc-Based Skin Ablation for Transdermal Drug Delivery ........................................................... 320Jeong Woo Lee

Formulation Development Strategies and Preliminary Clinical Results for Diindolylmethane, a Poorly Soluble Nutritional Supplement with Anti-Cancer and Anti-Viral Activity ............................................................................................................................ 322

Irwin Jacobs

Microencapsulation as a Tool for Food Fortification .................................................................. 324Yoav Blatt

Mucoadhesive Systems of Polyherbal Antimicrobial Formulation for Vaginal Drug Delivery ................................................................................................................................... 325

Shruti Chopra

Polymeric Microcapsules Entrapping Mesenchymal Stem Cells: A New Approach For Cell Based Therapy .................................................................................................................. 327

Amit Goren

Development of an Oral Osmotic Release System for Cardiovascular Disorders................... 329Juliana Marchetti

Clinical Studies of SP1049C, a Polymer-Based Anthracycline Effective Against Drug Resistant Tumors. ................................................................................................................. 331

Valery Alakhov

Development of A Novel Magnetic Resonance Imaging Contrast Agent for Imaging of Vascular Endothelial Dysfunction ............................................................................. 332

Kenjiro Ikuta

In vitro Evaluation of a Polymeric Contrast Agent for Monitoring Cancer Targeted Drug Delivery ................................................................................................................................... 334

Bahar Zarabi

Biodistribution, Clearance, and Biocompatibility of Iron-Oxide Magnetic Nanoparticles in Rats ..................................................................................................................... 336

Vinod Labhasetwar

Transit of Magnetic Tablets Using Magnetic Moment Imaging and Gamma Scintigraphy. ................................................................................................................................... 338

Kirsteen E Wilson

Oral Drug Nanocrystals: State of Industrial Development, Products and Future Trends .............................................................................................................................................. 340

Rainer Müller

An Injectable Nanosuspension for Itraconazole: Pharmacokinetic Evaluation in the Dog ............................................................................................................................................. 342

Marcus Brewster

Acid-Degradable Poly(N-vinylformamide)/Polyvinylamine Nanogel Capsules ........................ 344Cory Berkland

Co-entrapment of Cyclosporine A and Coenzyme Q10: Assessment of Polymeric Nanoparticles Ability to Entrap Two High Molecular Weight Lipophilic Compounds ..................................................................................................................................... 346

Jagdish Italai

Controlled Release of Docetaxel from Targeted Nanoparticles for Prostate Cancer Chemotherapy ................................................................................................................................. 348

Frank Gu

Potent Antibody-Drug Conjugates for Cancer Therapy.............................................................. 350Paul Carter

Overcoming MDR: Drug Delivery Systems with Monoclonal Antibodies and/or Cell-Penetrating Peptides .............................................................................................................. 351

Vladimir Torchilin

Targeted Delivery of Polymeric SMA-Aclarubicin Micelles for Reversing Anti-Cancer Drug Resistance................................................................................................................. 353

Khaled Greish

Targeted Delivery of Immunoliposomal Doxorubicin to B-lymphoid Cells via Anti-CD19 Monoclonal Antibodies and Fragments ............................................................................. 355

Wilson Cheng

A Matrix-type Microparticulate Formulation of Eudragit FS 30D for Delivery of Bioactive Compounds to Possum Hindgut .................................................................................. 357

Gopinath Devaraj

Aqueous-Soluble, Non-Reversible Lipid Conjugate of Salmon Calcitonin: Synthesis, Characterization and In Vivo Activity and Pharmacokinetics ................................. 359

Weiqiang Cheng

Cationic Polysaccharide Nanogels for Protein Delivery............................................................. 361Hirohito Ayame

Comparison of Zeta Potential and the Osmotic Second Virial Coefficient of Bovine Serum Albumin in the Determination of Protein Colloidal Stability. ............................ 362

Ravi Palaniappan

Controlled Release of Proteins and Polypeptides from Silica Microparticles.......................... 364Kim Finnie

Design and Evaluation of Controlled Release Buccoadhesive Tablets of Insulin ................... 366Jasjeet Sahni

Development of Peg-modified Liposomes Containing Hemoglobin Oxygen Carriers for Cell and Tissue Cultures ........................................................................................... 368

Valerie Centis

Effective G-CSF Site Directed PEGylation of Hindered Aminoacids ......................................... 370Stefano Salmaso

Effects of Sequential and Combinational Treatments of Chemotherapuetic Drugs and PEGylated TRAIL on Colon Tumor Models; in vitro and in vivo study.............................. 372

Su Young Chae

Evaluation of Sublingual Delivery of Glucagon Using eligen® Technology in a Dog Model ........................................................................................................................................ 374

Nai Fang Wang

Extraction of Trehalose during the Spray-Freeze / Solvent Extraction Preparation of PLGA Microparticles .................................................................................................................. 376

Michael Kennedy

GelSite® Polymer, a Versatile In-Situ Gelling Excipient for Sustained Peptide and Protein Delivery Systems ............................................................................................................... 378

Paul Stroud

Hyaluronic Acid – Chitosan Nanoparticles for the Controlled Release of Proangiogenic Factors ................................................................................................................... 380

Yolanda Parajo

In Situ Gelling Hydrogels Based on Oligolactate-grafted Dextran Microspheres.................... 382Sophie Van Tomme

In-situ Gelling Microemulsions Containing Lecithin and Capryl-caprylyl Glucoside As Nanoparticle Templates: Protein Delivery Systems with Depot Effect? ................................... 384

Anja Graf

In Vivo Pharmacological Activity of Oral Insulin Nanoparticles in Healthy and Diabetic Animal Model.................................................................................................................... 386

Bruno Sarmento

Induction of Instability in W/O/W Double Emulsions by Freeze-Thaw Cycling ........................ 388Edith Rojas

Injectable Hyaluronic Acid and TNF-Related Apoptosis-Inducing Ligand (TRAIL) Formulations ................................................................................................................................... 390

Seong Joo Na

Injectable pH/Temperature-Sensitive Hydrogel for Peptide and Protein Delivery .................. 392Doo Sung Lee

Interaction Between Insulin and N-trimethyl Chitosan During Microsphere Formulation ..................................................................................................................................... 394

Jan Steenekamp

Intermediate Permeability Behavior in a Drug Delivery Oscillator – Collapsed “Skin” Morphological Changes ..................................................................................................... 396

Amardeep Bhalla

Intracellular Processing and Apoptotic Activity of Cytochrome c-Oligoarginine Conjugates....................................................................................................................................... 398

Wei-Chiang Shen

Lecithin-cholesterol Implants for a Controlled Release of Proteins ......................................... 400Natalie Medlicott

Microparticulate Systems for the Delivery of DNase .................................................................. 402Chung-Yih Wang

Nanogel engineering for protein delivery system: Nanogel cross-linking hydrogel ............... 404Kazunari Akiyoshi

Nanoparticles from Different Structure-types of Microemulsions for Protein Delivery .......... 405Anja Graf

Neuropeptide Y Self-associates with Long-circulating, Biocompatible and Biodegradable Sterically Stabilized Phospholipid Nanomicelles Resulting in Amplified Bioactivity ............. 407

Esha Desai

Peptide Drug Delivery with Pheroid™ Technology ..................................................................... 409Abraham Kotze

Polymeric Matrix Development for Incorporation and Controlled Release of Papain............................................................................................................................................... 411

Patrícia Santos Lopes

Polymersome Encapsulation of Therapeutic Proteins ............................................................... 413David Christian

Preparation and Application of PEGylated TNF-related Apoptosis-Inducing Ligand (TRAIL) for Rheumatoid Arthritis Therapy ...................................................................... 415

Cheng-Hao Jin

Preparation and Characterization of Bioconjugated Glucagons-like Peptide-1 for Enhanced Peroral Delivery ............................................................................................................ 417

Kang Choon Lee

Preparation and Characterization of Lithocholic Acid Modified Exendin-4 (1-39) for Long-acting Therapeutic Agent for Type 2 Diabetes............................................................. 419

Kang Choon Lee

Rescue of Murine Ischemic Hindlimbs with Controlled-Release RhbFGF................................ 421Li Zhang

Self-microencapsulation in Biodegradable Polymers: A New Paradigm to Prepare Protein Controlled Release Polymers........................................................................................... 423

Samuel Reinhold

Shell-crosslinked Hyaluronic Acid/Poly-L-lysine Layer-by-Layer Polyelectrolyte Microcapsules Prepared by Removal of Reducible Hyaluronic Acid Microgel Core.............. 425

Hyukjin Lee

Silk Scaffolds As a New Application System for IGF I Loaded PLGA Microspheres .............. 426Esther Wenk

Stabilization Of Interferon In A Mucoadhesive Formulation ...................................................... 428Giuseppina Sandri

Successful Proof of Concept with ImSus Platform Technology: Preclinical Development of a 1-Month Controlled Release Formulation for a Non-Disclosed Peptide Drug .................................................................................................................................... 430

Celal Albayrak

Thermosensitive Copolymers for Controlled Release of Insulin: In Vitro Release and Stability..................................................................................................................................... 432

Jagdish Singh

Transport of a Very Rapid Acting Insulin Formulation, VIAject™, Through Oral Epithelium ........................................................................................................................................ 434

Solomon Steiner

Anionic Polymersomes for Controlled Release........................................................................... 436David Christian

Antitumor Activity of DACHPt-loaded Polymeric Micelles Against a Bioluminescent Lung Metastasis Tumor Model .......................................................................... 438

Horacio Cabral

Controlled Dual Release of bFGF and Indomethacin from Heparinized Polymeric Micelle .............................................................................................................................................. 440

Dong Hyun Go

Development of Stealth Nanoparticles with High Anti-inflammatory Activity.......................... 442Tsutomu Ishihara

Development of the Mixed Micelles That Deliver Multiple Drugs Doxorubicin (dox) and Wortmannin (wor) Simultaneously for Combination Cancer Chemotherapy ................... 444

Younsoo Bae

Hydrogel Nanoparticles Based on Hyaluronic Acid as Potential Drug Carriers ...................... 446Ki Young Choi

Hydrophobic Prodrug Strategy as a Route to Creation of pH Sensitive Micelles.................... 448Damon Sutton

Incorporation Behavior of Camptothecin into Polymeric Micelles in various Isomerization Ratios and Hydrophobic Group Contents of Inner Block .................................. 450

Tatsuhiro Yamamoto

Micellar Form of Novel Poorly Soluble Pro-apoptotic Agent, Dimethyl-PIT ............................. 452Igor Skidan

Micelles from Cholesteryl-Conjugated siRNA and Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE) for Enhanced Intracellular Delivery of siRNA .............. 454

Tatyana Levchenko

Mixed Micelles Made of Pluronic and PEG-PE for Solubilization of Poorly Soluble Anticancer Drug Paclitaxel ............................................................................................................ 456

Vladimir Torchilin

Nanocarrier Formulation of a Geldanamycin Prodrug in ABC Micelles: Pharmacokinetics and Tolerability in Rats .................................................................................. 458

M. Laird Forrest

Paclitaxel Release from Hydrotropic Micelles with pH-sensitive Moiety .................................. 460Ji Young Kim

Pharmacokinetics of Nanoencapsulated Paclitaxel Hexonate Prodrug in Poly(ethylene glycol)-block-poly(e-caprolactone) Micelles........................................................ 462

M. Laird Forrest

Polymeric Micelles Made of Poly(Isoprene-Block-Ethylene Oxide) Block Copolymer for Solubilization of Poorly Soluble Drugs............................................................... 464

Tatyana Levchenko

Preparation and Characterization of Folate-mediated Nanoparticles Based on Poly(e-caprolactone) and Chondroitin Sulfate ............................................................................ 466

Li-Fang Wang

Regulation of Nano-Micelle Thermoresponse via Heterogeneous End-Functional Block Copolymer Blends and Incorporation of Hydrophobic Drugs ........................................ 468

Masamichi Nakayama

Targeted Charge-Reversal Nanoparticles for Nuclear Drug Delivery........................................ 470Youqing Shen

Worm Micelles carrying Tissue Plasminogen Activator as Prophylactic Fibrinolytic Agents.......................................................................................................................... 472

Younghoon Kim

Advances in Terahertz Pulsed Imaging as Process Analytical Technology for Tablet Film Coating......................................................................................................................... 474

Louise Ho

Dehydration of Piroxicam Monohydrate from Compacts Using Terahertz Pulsed Spectroscopy, Raman Spectroscopy and Near Infrared Spectroscopy ................................... 476

Thomas Rades

Development of Microcapsule of Diclofenac Sodium by Phase Separation Technique ........................................................................................................................................ 478

Manpreet Kaur

Effect of Drug Properties and Dissolution Medium on the In Vitro Release From Carbomer Matrix Tablets ................................................................................................................ 480

Elena Draganoiu

Formation and Stability of Amorphous Ranitidine Hydrochloride Prepared by Cryo-milling ..................................................................................................................................... 482

Norman Chieng

Investigation of Physico-chemical Properties and Stability of Two Amorphous Forms of Simvastatin...................................................................................................................... 484

Thomas Rades

Quantifying Ternary Mixtures of Different Solid-state Forms of Indomethacin by Near-infrared Spectroscopy and Partial Least Squares Analysis ............................................. 486

Thomas Rades

The Influence of Material Properties on the Quantitative X-ray Powder Diffraction and Raman Spectroscopy .............................................................................................................. 488

Thomas Rades

Using Multivariate Visualization to Screen for Differences in the Stability of Amorphous Indomethacin ............................................................................................................. 490

Thomas Rades

Chitosan Coated PLGA: Poloxamer Nanocarriers for the Mucosal Delivery of the Recombinant Hepatitis B Surface Antigen................................................................................... 492

Patrizia Paolicelli

Chitosan Derivatives for Pulmonary DNA Vaccination: Functionalization with Toll-like Receptor (TLR) Agonists......................................................................................................... 494

Simon Borchard

Development of Patch Vaccine System: Mechanism of Transcutaneous Immunization ................................................................................................................................... 496

Fumio Kamiyama

Effect of Emulsion Stabiliser on Microsphere Based Tuberculosis Vaccine Efficacy ............................................................................................................................................ 498

Daniel Kirby

Effect of the Degree of Quaternization of Trimethyl Chitosan As Mucosal Adjuvants Following Intranasal Immunization ............................................................................ 500

Worawan Boonyo

Evaluation of Albumin Microspheres As a Potential Delivery Vehicle for Oral Tuberculosis Vaccines ................................................................................................................... 502

Kwame Yeboah

Evaluation of in Vitro Gene Delivery Through Single and Double Chain Hydro and Perfluorinated Bolaamphiphiles ............................................................................................ 504

Bernard Pucci

Flocculated PLG Nanoparticles for Inhaled Vaccine Delivery ................................................... 506Cory Berkland

Functionalisation of PLGA Microspheres for Targeting Macrophages.................................... 508Nolwenn Brandhonneur

In vivo Activity of Cationic Immune Stimulating Complexes (PLUSCOMs).............................. 510Warren McBurney

In Vitro and in Vivo Investigation of Quil-A Containing Biodegradable Immunostimulatory Implants ......................................................................................................... 512

Julia Myschik

Liposaccharide Based Vaccine against Group A Streptococcal Infection ............................... 514Pavla Simerska

Modulation of Immune Response from Vaccine loaded Polymer Particles: Effect of Size............................................................................................................................................... 516

Vibhu Kanchan

Nanoparticles Composed of Amphiphilic Poly(amino Acid) for Enhanced Protein Delivery to Dendritic Cells As Vaccine Adjuvants....................................................................... 518

Takami Akagi

Novel Cationic Lipidic Dendron - PLA-PEG Nanocomposites for Vaccine Delivery ............... 520Oya Alpar

PLGA-DNA Vaccines: From Targeting to Efficient Transfection .............................................. 522Jacob Gvili

Stability Evaluation of Antigens from Neisseria Meningitides Serogroup B Adsorbed on Anionic PLG Microparticles.................................................................................... 524

Jina Kazzaz

Surface Functionalized Microparticles for Combinatorial Delivery of DNA Antigens and Adjuvants ................................................................................................................. 526

Ankur Singh

Surface Modified Biodegradable Microparticles As Delivery System for a Synthetic Carbohydrate Vaccine Candidate ................................................................................ 528

Noemi Csaba

Targeting Vaccines to Dendritic Cells: Enhanced Uptake of Polymer Particles Facilitated by a Monomeric CD40 Ligand..................................................................................... 530

Noelle Palumbo

Volume 2

The Posintro/TransVac™ Adjuvant Delivery System is Efficient and Well Tolerable for Transcutaneous Immunization ...................................................................................................... 532

Annette Heydenreich

TMC-MCC Complex Nanoparticles for Mucosal Immunisation .................................................. 534Sevda Senel

Towards the Development of Controlled Release Cancer Vaccines ......................................... 536Sarah Hook

Transcutaneous Immunization with Antigen-loaded PLA Nanospheres .................................. 538George Mattheolabakis

A Comparative Study of the Aerodynamic and Drug Release Properties of a Range of Polymeric Microspheres for Controlled Protein Delivery to the Lungs.................... 540

Neeraj Sivadas

A PAMAM Gd-DO3A Conjugate with a Degradable Disulfide Spacer for Magnetic Resonance Imaging ........................................................................................................................ 542

Rongzuo Xu

An In Vitro and In Vivo Study of ProNeuraTM EVA-Lisuride Implants for Sustained Drug Release ................................................................................................................................... 544

Joe McDonough

Assessment of a Herbal Formulation for Wound Healing Activity in Rats Using a Bioadhesive Polymer...................................................................................................................... 546

Sushma Mengi

Autologous Fat Transplantation in Severe Burn Scar Outcomes: A New Perspective for Cell Therapy and Tissue Engineering................................................................ 548

Marco Klinger

Biocompatibility Study of the Mucosal Formulations ................................................................. 550Jin-Wook Yoo

Biodegradable and In Situ Forming Hydrogel Drug Delivery System Based on Unsaturated Poly(ethylene glycol) Block Copolymers for Tamoxifen Citrate Delivery ............................................................................................................................................ 552

Azadeh S. Hashemi Doulabi

Chitosan Citrate as Vaginal Penetration Enhancer With Enzymatic Inhibition Properties ........................................................................................................................................ 554

Giuseppina Sandri

Chondrogenic Differentiation of PLA cells in 3D-HA Matrix....................................................... 556In Soo Yoon

Delivery Systems of Active Ingredients........................................................................................ 558Ted Slaghek

Development of a Citric Acid Polyester Gel with Biodegradability and pH Responsive Drug Release .............................................................................................................. 560

Kumao Uchida

Development of Polyvinyl Alcohol and Sodium alginate Gel Based Clindamycin Wound Dressing by Freeze-thawing Method ............................................................................... 562

Choi Yong

Development of Liposome Formulation Incorporated with Nitrosyl Ruthenium Complexes for PDT Application .................................................................................................... 564

Renata de Lima

Diffusion from Silicone Elastomer Matrices ................................................................................ 566Eileen McBride

Diffusion in Poly(lactide-co-glycolide) and Dichloromethane Mixtures.................................... 568Willard Foss

Effect of Terbinafine Hydrochloride Incorporated into Chitosan Gels on Candida Albicans: Ex-Vivo Evaluations ...................................................................................................... 570

Ipek Ozcan

Engineering of Biocompatible Biodegradable Alginate Foams ................................................. 572Therese Andersen

Evaluation of In-Vitro Release Properties of Vancomycin Microspheres Prepared with Polyaspartic Acid.................................................................................................................... 574

Ipek Ozcan

Fabrication and Characterization of Novel Porous CaCO3 Polyelectrolyte Microcapsules ................................................................................................................................. 576

Raid G Alany

Fabrication of Drug-loaded Microfibers via Solvent Removal ................................................... 578Danya Decoteau

Hepatoprotective and Antioxidant Effects of Cuscuta chinensis and its Nanospheres on Acetaminophen-Induced Acute Liver Injury in Rats ...................................... 580

Feng-Lin Yen

Highly Soluble Drug in Microgranules Prepared with Crosslinked Pectin and Embedded in a Mucoadhesive Polymer Matrix............................................................................ 582

Marcin Placzek

Hydrogel-like Scaffolds for Neocartilage Formation Using Rabbit Chondrocytes .................. 584Park Ji Sun

Impact of Digestion on Pharmaceutical Surfactants................................................................... 586Sandra Klein

Improvement of Chitosan Penetration Enhancement Properties by Ionic Interaction with Ascorbic Acid ...................................................................................................... 588

Giuseppina Sandri

Injectable Microdispersions for Drug Delivery ............................................................................ 590Aruna Nathan

Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces Size and Number of Endometriosis Implants in Rats ................................................................................. 592

Elran Haber

Long -Circulating Biodegradable Nanoparticles Prepared with PLA-PEG-COOH or PLGA-PEG-COOH Copolymers for Targeted Delivery ................................................................ 594

Tania Betancourt

Modified Release Patterns of PLGA Hot-melt Extruded Implants ............................................. 596Duangratana Shuwisitkul

Modified-Release of IgG from Poly(lactide-co-glycolide) Microparticles for Pulmonary Delivery: Comparison of Uncapped and Capped Polymers ................................... 598

Richard Kaye

Non-Invasive Characterization of Hydroxyapatite Loaded Collagen-Chitosan-Scaffolds for Bone ........................................................................................................................................... 600

Hagen Nitzsche

Novel Glycol Chitosan Hydrogels: pH-Sensitive Swelling, Biodegradation, and Drug Release Behavior................................................................................................................... 602

Yeon Hee Yun

Phosphorylation Of Starch Via Reactive Extrusion For Controlled Release of Drugs ........... 604Stephen O'Brien

Poly(ether-anhydride) Nanoparticles for Prolonged Anti-Cancer Drug Delivery ..................... 606Benjamin Tang

Polystyrene Microballons: A Gastro-Retentive Control Release System ................................. 608Aviral Jain

Preparation of N-acylchitosan Microspheres for Controlled Release of 6-Mercaptourine ..... 610Shu-Huei Yu

Preparation of w/o/w Templates for Preparation of Polysester Microparticles by a Single Step In-Line Emulsification. ............................................................................................... 612

Hsin-I Chang

Prolonged Release of 2-methoxyestradiol from Hydrogels ....................................................... 614Colleen Brophy

Protein Release from Self-Assembled Hydrogels ....................................................................... 616Menno de Jong

Role of Lipid Rafts in Innate Immunity and Phagocytosis of Polymer-Based Particles ......... 618Kazuo Ishii

Sequentially Crosslinked Biodegradable Poly (b-amino esters) for Drug Delivery ................. 620Santosh Hire

Statistical Approach in Alginate Membrane Formulation for Cell Encapsulation in a GMP-based cell factory ............................................................................................................... 622

Marco Klinger

Surface Characterization of Poly(lactic acid)/Everolimus and Poly(ethylene vinyl alcohol)/ Everolimus Stents ........................................................................................................... 624

Ming Wu

The Use of Design of Experiment to Optimise the Drug Loading Process in a Vaginal Hydrogel Formulation ....................................................................................................... 626

Alistair Ross

Transesterification and End Group Chemistry in Acid Terminated Biodegradable Polymers .......................................................................................................................................... 628

Keith Branham

Use of mucoadhesive Chitosan to Enhance the Cellular Association of Paclitaxel into 4T1 Cells Delivered in PLGA Nano- or Microparticles......................................................... 630

Sudhir Chakravarthi

Brain Cancer Therapy in Rats by Combination Use of PLGA Microspheres Containing Anti-cancer Drug and Thermoreversible Gelation Polymer ................................... 632

Tetsuya Ozeki

Cationic Beta-cyclodextrins for Doxorubicin Delivery Across the Blood Brain Barrier .............................................................................................................................................. 634

Eun Seok Gil

Design and Evaluation of Dopamine (DA) Nanoparticles Dispersed Within a Scaffold for Intracranial Implantation ........................................................................................... 636

Samantha Pillay

Encapsulation of Moxifloxacin in Poly(butyl cyanoacrylate) Nanoparticles Enhances Efficacy against Mycobacterium tuberculosis........................................................... 638

Svetlana Gelperina

Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with CaCO-2 Cells .............. 640Kelly Kitchens

Hybrid of Cell Penetrating Peptide and Drug Binding Motif Traffic the Delivery of MDR Drug......................................................................................................................................... 642

Zhaohua Zheng

Nondegradative Trafficking of Nanoparticles to the Nuclear Region Based Solely on Size.............................................................................................................................................. 644

Samuel Lai

Novel Nanocarriers for Patient-specific Brain Tumor Therapy .................................................. 646Efstathios Karathanasis

Paclitaxel and Ceramide Combination Therapy in Biodegradable Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer .................................................... 648

Harikrishna Devalapally

Sustained intracellular Concentrations of Mometasone furoate Upon Administration in WGA-conjugated PLGA nanoparticles........................................................... 650

Sachin Naik

Transferrin Coupled PEGylated Nanoparticles for Brain Tumor Targeting.............................. 652Aviral Jain

Uptake and Intracellular Fate of Lipid-Based Particles Inside Individual Cells by Raman Micro-Spectroscopy: Studies with Plain and TAT-Modified Liposomes..................... 654

Vladimir Torchilin

Comparison of Alginate Matrix Capsules and Gelatin Matrix Capsules: Effect of Matrix Forming Materials on Flavor Release Kinetics ................................................................ 656

Jing Zhang

Flavor Release through Polymer Films using a Dynamic Vapor Gravimetric Apparatus ........................................................................................................................................ 658

Daniel Burnett

Importance of Nutraceuticals - An Overview ............................................................................... 660Rashmi Kumari

Microspheres Based on Soy, Zein Protein As Oral Delivery Vehicles - Microsphere Fabrication, Characterization and Dissolution Properties................................... 662

Lingyun Chen

Milk Casein Micellesas Potential Natural Carriers for Nutraceuticals: Electron Microscopy and Image Analysis ................................................................................................... 664

Marco Klinger

Soft Capsule as Gastrointestinal Reflux Resistant Delivery System: Concept & Delayed Release Profiles of GRAS Dietary Supplements........................................................... 666

Nachiappan Chidambram

A Cremophor-Free Formulation for 17-AAG using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats ......................................................................... 668

May Xiong

A Heparin/Poly (l-lysine) Nanoparticle-Coated Polymeric Microspheres ................................. 670Sun Bo-Kyung

A New Possibility to Determine Size Distributions of Biodegradable Nanoparticles: Characterizing PLGA Nanospheres by Separation via Flow-FFF and Detection via MALS ................................................................................................................. 672

Karsten Mäder

A Novel Approach to Surface Functionalization of Nanoparticles: I. PEGylation ................... 674Yogesh Patil

Antigen-Conjugated Liposomes Enhanced Hyposensitization Immune Therapy with Extra-Low Doses..................................................................................................................... 676

Haruna Miyauchi

Cell Engineering of Corneal Epithelium by a Bowman's Membrane-mimic Nanofibrous Membrane .................................................................................................................. 678

How Tseng

Charge-Reversal PAMAM Dendrimer............................................................................................ 680Youqing Shen

Comparison of Different Homogenization Technologies to Produce Ultrafine Testosterone Nanocrystals ........................................................................................................... 682

Rachmat Mauludin

Conformally Coated Nanoparticle-Doxorubicin Therapy for Brain Tumors ............................. 684Chen-Yu Kao

Design and Characterization of Poly(lactide-co-glycolide) Nanoparticles Prepared with Polaxamer for Better Delivery of Paclitaxel ......................................................................... 686

Ranendra Saha

Designing and Characterization of Solid Lipid Nanoparticles Loaded With Terbinafine Hydrochloride ............................................................................................................. 688

Amol Borade

Development of Ascorbyl Palmitate Nanosuspension for Topical Drug Delivery System ............................................................................................................................................. 690

Veerawat Teeranachaideekul

Dual Growth Factor Loaded Scaffolds for Cell Effect ................................................................. 692Joo Mi Kim

Effect of Cross-linking Methods on Particle Size Distribution of Chitosan Nanoparticles .................................................................................................................................. 695

Anitha Dudhani

Effect of Particle Size on Solubility Properties of Ibuprofen Powder: Nanocrystallization by Ball-Milling................................................................................................ 697

Leena Peltonen

Effect of Type of Organic Phase Solvents on Preparation of Poly(D,L-lactide-co-glycolide) Nanoparticles and Release Characteristics in Vivo .................................................. 699

Girish Mittal

Effervescent Powders for Pulmonary Nanoparticle Delivery ..................................................... 701Raimar Löbenberg

Electrospinning of Collagen Type Nanofibers Onto an Anodic Oxidized Titanium Surface Enhances Osteoblast-like Cell Attachment ................................................................... 703

Sangwon Suh

Enhancing Plasma Clot Lysis by PLGA Nanoparticles Encapsulated t-PA – Effects of Coating with Chitosan and RGD .................................................................................. 705

Tze-Wen Chung

Evaluation of Novel Cationic Core-shell Chitosan Nanoparticles for Non-viral DNA Delivery ................................................................................................................................... 707

Suvimol Surassmo

Bio-adhesive Vaginal Foam – In-vitro and In-vivo Adhesion Profile ......................................... 709Doron Friedman

Formulation of Chemically Crosslinked Albumin-Chitosan Mixed Matrix Microparticulate Systems .............................................................................................................. 711

Karyn Cotta

In vitro and In vivo Occlusion Properties of Nanostructured Lipid Carriers (NLC) ................. 713Jana Pardeike

In Vitro and In Vivo Pharmacokinetic Characterization of Short Chain C6-Ceramide Liposomes...................................................................................................................... 715

Banu Zolnik

Increased Uptake of “Smart” pH-Sensitive TAT Peptide-Bearing Liposomes by Cardiac Cells in Perfused Langendorff Heart Model ................................................................... 717

Amit Kale

Investigation Of Solid Lipid Nanoparticles With Clarithromycin For The Improvement Of Therapeutic Utility .............................................................................................. 719

Mukesh Shahare

Lactose Conjugated PLGA Nanoparticles for Lung Targeting................................................... 721Aviral Jain

Alginate Sodium/Eudragit® E PO Interpolyelectrolyte Complexes for Colon Drug Delivery ............................................................................................................................................ 723

Rouslan Moustafine

Bile Acid Conjugated Chitosan Oilgosaccharide Nanoparticles for Anticancer Agent Carrier ................................................................................................................................... 725

Changyong Choi

Bio-inspired Peptide-Poly(Ethylene Oxide) Coated Iron Oxide Nanoparticles Applicable for MRI........................................................................................................................... 727

Julia Maier

Biodegradable Diclofenac Microcapsules for Sustained Drug Delivery System. .................... 729Manoj Charde

Biosynthesized Thermosensitive Drug Carriers for the Delivery of HSP90 (Heat Shock Protein 90) Inhibitor Geldanamycin (GA) Via Hyperthermal Tumor Targeting .......................................................................................................................................... 731

Younsoo Bae

Can Chitosans Get Sterilized by Electron Irradiation? Monitoring Chitosan Degradation by Flow Field-Flow Fractionation and Multi-Angle Light Scattering ................... 733

Karsten Mäder

Characterization of Acetaminophen Sustained Release Matrix Tablets Made with Eudragit® NM 30 D.......................................................................................................................... 735

Susan Shabana

Chitosan Nanoparticles Based on Polyelctrolyte Complexes of All-trans Retinoic Acid and Methoxy Poly (ethylene Glycol)-grafted-chitosan ....................................................... 737

Dong-Gon Kim

Comparative Evaluation of Chitosan/Eudragit® L100-55 Polycomplex Matrix Systems ........................................................................................................................................... 739

Evgenya Margulis

Degradation of PCL-MPEG Diblock Copolymer in Rat Plasma .................................................. 741Wen Jen Lin

Development of Extended Release Gastrorentive Dosages of Ibuprofen ................................ 743Shaukat Ali

Development of Reversible Hydrophilic/Hydrophobic Surfaces ............................................... 745Richard Suzuki

Dissolution of Ibuprofen from PVP-40 and PEG-8000 Solid Dispersions ................................. 746Zine Elabidine Nacer

Drug Delivery Carrier Using Polymeric Micelle with Iron Oxide Nanoparicles ........................ 748Hye Jung Choi

Floating Pulsatile Drug Delivery Using Cavilink™ for Chronotherapy. .................................... 750Praveen Sher

Formulation Optimization of Photocrosslinked Polyacrylic Acid Hydrogel As an Adhesive for Dematological Patches............................................................................................ 752

Yoshinori Onuki

Heparin-Immobilized Microparticles for Sustained Drug Delivery ............................................ 754Keun Sang Oh

Improved Efficacy of Poly(I:C) Mediated Immunostimulation of Dendritic Cells via a PLL-g-PEG Surface-Coated Microparticle ................................................................................ 756

Annina Hafner

In vivo-In vitro Biodegradation and Tissue Compatibility of Novel Biomaterial used as Ciprofloxacin Implant for Drug Delivery System........................................................... 758

Rita Chakole

Methacrylated Hyperbranched Polyglycerol Hydrogels: Preparation and Physical Characterization .............................................................................................................................. 760

Marion Oudshoorn

Molecular Design of Novel Biodegradable pH and Temperature- Sensitive Block Copolymer Hydrogels..................................................................................................................... 762

Minh Khanh Nguyen

Nanoparticles Preparation by Graft Copolymerisation of 2-Hydroxyethyl Methacrylate onto Thiolated Chitosan.......................................................................................... 764

Firooze Aghaei Moghaddam

New Polymeric Micelle as Drug Carriers for the Photodynamic Therapy................................. 766Chau-Hui Wang

Novel Degradable Polymer for the Controlled Release of Hydrophobic Drugs as a Drug Eluting Stent Coating ............................................................................................................ 768

Laura Patrick

Novel Film Forming Polyacid-Polybase Blends For Tailoring Drug Release ........................... 770Anupa Menjoge

Novel Poly(hexyl-substituted-lactide) based Drug Delivery Systems: Injectable Semi-solid hexPLAs and PEG-hexPLA-Micelles ......................................................................... 772

Michael Möller

Performance of Degradable Polyester Block Copolymers as Drug-Eluting Stent Coatings ........................................................................................................................................... 774

Nathan Lockwood

Polyvinyl Alcohol Grafted Polyethylene Glycol Copolymer for Application in Floating Drug Delivery Systems .................................................................................................... 776

Shaukat Ali

Release Characteristics of Lidocaine from Swellable Local Implant of Polyethyleneimine-Polyvinyl pyrrolidone (PEI-PVP) Hydrogel .................................................. 778

Ming-Thau Sheu

Semitelechelic Beta-Cyclodextrin-Poly(4-acryloylmorpholine) Conjugates For Drug Delivery ................................................................................................................................... 780

Marco Bencini

Sustained Release Chitosan Microspheres Prepared By a W/O/W Emulsion-Spray Drying Method ................................................................................................................................. 782

Inés Paños

Synthesis of Linear Multifunctional Poly(ethylene glycol) as Novel Drug Delivery Systems ........................................................................................................................................... 784

Xin-Ming Liu

Synthesis of Novel Liquid Crystalline Block Copolymer for Effective Encapsulation of Drugs.................................................................................................................. 786

Masamichi Nishihara

Synthesis, Characterization and Antibacterial Effects of Trimethylated 6-NH2-6-Deoxy Chitosan ............................................................................................................................... 788

Assal M.M.Sadeghi

Vehicle using Low Molecular Water Soluble Chitosan for Target the Specific Tissue ............................................................................................................................................... 790

Mi-Kyeong Jang

Amphotericin B – Loaded Lipid Nanospheres and Their in vitro and in vivo Characteristics ................................................................................................................................ 792

Suk Hyun Jung

Comparative Activity of Two Novel Methotrexate-Loaded W/O Microemulsions on Human Breast Cancer Cell Lines .................................................................................................. 794

Yesim Karasulu

Doxorubicin-conjugated Liposomes for Intracellular Delivery of Anti-cancer Drug ............... 796Byung Chul Shin

ESEM: An Alternative Assay for Investigating Liposome Stability. .......................................... 798Habib Ali

Formulation and Characterisation of Nanoparticulate Systems for Oral Delivery of L-Glutathione ................................................................................................................................... 800

J-Y Wen

Intracellular DNA Delivery by Chitosan-coated PLGA Nanoparticles ....................................... 802Richard Gemeinhart

Loading to Solid Lipid Nanoparticles (SLN) Improves Cutaneous Uptake of Glucocorticoides Widely Varying in Lipophilicity ...................................................................... 804

Peggy Schlupp

MAXITARG-DOX: Hepatic Targeted Drug Delivery System With Reduced Cardiac and Renal Toxicity .......................................................................................................................... 806

Rajesh Patil

Nanoparticles for Protein Delivery from Microemulsions Containing Lecithin and Decyl Glucoside .............................................................................................................................. 808

Anja Graf

Phytosterosomes: Polyoxyethylene Phytosterol Vesicles: Their Preparation, Characterization and Transdermal Application ........................................................................... 810

Gopinath Devaraj

Preparation and characterization of Long Circulating Nanoemulsion for Passive Tumor Targeting.............................................................................................................................. 812

Srinivas Ganta

Purified, Ubiquinone-loaded and Surfactant-free PLGA Nanoparticles.................................... 814Barrett Nehilla

Self-associating poly(ethylene oxide)-block-poly(eeee-caprolactone) copolymers with carboxyl, benzyl carboxylate and doxorubicin side group: Novel micellar nano-containers and drug conjugates.......................................................................................... 816

Abdullah Mahmud

Solid Lipid Nanoparticles of Methotrexate ................................................................................... 818Madhur Kulkarni

Solvent-free Biodegradable Nanoparticles as Carriers for Hydrophobic and Hydrophilic Drugs ........................................................................................................................... 820

Andrew Loxley

Chitosan/PVA Film for Ocular Drug Delivery of Water Soluble Antimicrobial Agents .............................................................................................................................................. 822

Bhupendra Prajapati

Development and Characterization of a Biodegradable Intraocular System Containing Cyclosporine A for the Treatment of Posterior Uveitis. .......................................... 823

Armando S Cunha

Effect of Enzymatic Degradation on Cyclosporine Release from Solid Lipid Nanoparticles and Determination of Cellular Uptake by Confocal Microscope ....................... 825

Evren H. Gokce

In Vitro Evaluation of Sulphacetamide Sodium Microspheres for Ocular Drug Delivery ............................................................................................................................................ 827

Nazan Bergisadi

In Vitro Ocular Delivery of Fluconazole from Two Mucoadhesive Hydrogels. ......................... 829Taís Gratieri

Novel Solid Lipid Nanoparticle Formulation for Delivery of Diclofenac Sodium to the Eye ............................................................................................................................................. 831

Anthony Attama

Preparation and In Vitro Characterization of Microspheres Containing A Macrolide Drug: Rokitamycin ........................................................................................................ 833

Giuseppina Sandri

Water-soluble Chitosan-PAA Nanosuspension for Ophthalmic Delivery of Pilocarpine ....................................................................................................................................... 835

Hong-Ru Lin

A Novel Approach for the Transdermal Delivery of Macromolecules with Biochemical Enhancers.................................................................................................................. 837

Ying-shu Quan

An Optimized Pin Prick Test for the Pharmacodynamic Quantification of the Cutaneous Penetration of Local Anaesthetics: A Pilot Study................................................... 839

Claudia Leopold

Assessment of Barrier Perturbation Caused by Maltose Microneedles ................................... 841Chandra Sekhar Kolli

Controlled Delivery of Ambroxol using the Ethylene-Vinyl Acetate.......................................... 843Yun-Sam Kim

Correlation of In Vitro Transport to the Integrated PK-PD Profiles Following Transdermal Iontophoresis of Dopamine Agonist 5-OH-DPAT in Rats ................................... 845

Joke A. Bouwstra

Delivery of pHIS-HIV-hugag into Skin using Solid Lipid Nanoparticles and Chitosan Nanoparticles .................................................................................................................. 847

Rathapon Asasutjarit

Demonstration of Dose-controlled Delivery by Dissolvable Micro-needle Arrays .................. 849Seajin Oh

Development of a Liposomal Topical Drug for Acne Treatment................................................ 851Ae-June Wang

Development of Adhesive PVA/PVP/SA Hydrogel Containing Sodium Fusidate for Wound Dressing.............................................................................................................................. 853

Sung Giu Jin

Distribution of FGF-2 Within Excisional Wounds Following Topical Application.................... 855Natalie Medlicott

Effective Topical Delivery of Peptides and Proteins Following Formulation in a Water-in-Oil Microemulsion ........................................................................................................... 857

Gregory Russell-Jones

Electrotransport Kinetics of Metoclopramide Across Porcine Skin in Vitro ............................ 859Jennyfer Cazares-Delgadillo

Enhanced Transdermal Delivery of Melatonin via Elastic Liposomes Coupled Iontophoresis .................................................................................................................................. 861

Vaibhav Dubey

Enhancement of Skin Penetration of P20 Phosphopeptide Using a Protein Transduction Domain ..................................................................................................................... 863

Luciana Lopes

Enhancement of the Transdermal Delivery of Capsaicin Derivative- Sodium Nonivamide Acetate by Microemulsion ........................................................................................ 865

Yong-Hao Lin

Enhancement of Transdermal Permeation of Granisetron......................................................... 867David Houze

Evaluate Microneedle Array Pretreatment for Transdermal Drug Delivery .............................. 869Guang Yan

Formulation and In Vitro Evaluation of Membranes for Transdermal Administration................................................................................................................................. 871

Amalia Rodriguez Bayon

Human Reconstructed Skin Models for Absorption Testing: Comparison of hydrocortisone and testosterone formulations ........................................................................... 873

Sylvia Schreiber

Improving Safety of Trasdermally Administered Potent Opioids by Incorporating a Rate-controlling Membrane ........................................................................................................ 875

Christopher Adams

In Vitro and in Vivo Evaluations of Microemulsion Formulations of CZ48, Lactone-Stabilized Camptothecin-C20-Propionate, for Transdermal Delivery........................................ 876

Yousif Rojeab

In Vitro Evaluation of Clobetasol 17-Propionate Topical Cream Formulations........................ 878Roderick Walker

In Vitro Modeling of Transdermal PTH Delivery by Dissolving Micro-needle Patch................ 880Sung-Yun Kwon

In Vitro Transdermal Delivery of Human IgG across Hairless Rat Skin .................................... 882Guohua Li

In-Vitro Transdermal Permeation Comparison of Cetirizine Base vs. Cetirizine Dihydrochloride............................................................................................................................... 884

Samara Hantman

Iontophoretic Delivery of Cream and Gel Formulations of Acyclovir ....................................... 886Srujana Siddoju

Measurement of Equilibrium Drug Concentrations in Polymers: Time-Resolved Fourier-Transform Infrared (FT-IR) Attenuated Total Reflection (ATR) Spectroscopy .................................................................................................................................. 888

Karen Schultz

Non-ionic Surfactant Based Nanovesicular Carrier for Permeation Enhancement of BCS Class IV Drug...................................................................................................................... 890

Adnan Azeem

Preparation Ketoprofen Formulations with Multi-Enhancers..................................................... 892Pao-Chu Wu

Reduction in Obesity in Swiss Mice Following Topical Administration of Insulin .................. 894Gregory Russell-Jones

Stratum Corneum Microstructure and Implications to Size Dependent Penetration .............. 895Vijay John

Synthesis and Evaluation of Skin Permeation and Accumulation Profiles of Ketorolac Fatty Acid Esters ........................................................................................................... 897

Krishna Bhandari

Synthesis and Transdermal Penetration of Selected Lamivudine Derivatives ........................ 899Jeanetta Du Plessis

Synthesis and Transdermal Penetration of Selected Stavudine Derivatives ........................... 901Jeanetta Du Plessis

The Effect of Temperature on the Co-polymerization Of NIPAAM-VP....................................... 903Swati Aerry

The Novel Permeation Enhancers Dodecyl-2-N, N-dimethylaminopropionate (DDAIP) and HCl Salt: Physiochemical Properties, Preclinical Safety and In Vitro Permeation Enhancement .............................................................................................................. 905

William Pfister

The Percutaneous Study of the Emulsion and Vesicle Containing Pseudo-Ceramide .......................................................................................................................................... 907

Masaru Hosokawa

Topical Indomethacin in a Novel Eutectic Colloidal Delivery System: Comparative Study with Oral and Topical NSAIDs ........................................................................................... 909

Joseph Schwarz

Transdermal Delivery of Meloxicam Salts Enhanced by Iontophoresis/Electroporation and Evaluated In Vitro................................................................ 911

Yi-Hung Tsai

Transdermal Drug Delivery Enhanced by Magainin Pore-forming Peptide: Modification of Electrostatic Interactions by Changing pH........................................................ 913

Yeu-chun Kim

Transdermal Iontophoretic Delivery of Granisetron Across Porcine Skin in Vitro.................. 915Jennyfer Cazares-Delgadillo

Transdermal Iontophoretic Delivery of Ketoprofen..................................................................... 917J. Anand Subramony

Transdermal Permeation of Trimetazidine from Nerodilol-based HPMC Gel Drug Reservoir System Across Rat Epidermis ..................................................................................... 919

Yellela Krishnaiah

Development of a Novel Dissolution Test Method for the Evaluation of In Vitro Release from Drug-Eluting Stents................................................................................................. 921

Anne Neubert

Mathematical Model for Design of Biodurable Drug-Eluting Stent Coatings ........................... 923Santosh Prabhu

Micropatterning of RGDC Peptide For 2D Cell Guidance ........................................................... 925Sing Tze Kho

Monitoring of Self Assembly Behavior of Chitosan Derivatives in Aqueous Solution by Photon Correlation Spectroscopy (PCS) ................................................................. 927

Shahriar Abashzadeh

Photoinitiator-free Photopolymerization Technique for Hydrogels Synthesis Involving Ampholytic Charge-Transfer Complex ........................................................................ 929

Loo-Teck Ng

Physicochemical Features of Vernix Caseosa Change Within Physiological Temperature Range ........................................................................................................................ 931

Joke Bouwstra

PLGA Microsphere/PVA Hydrogel Composites for Long-term Localized Inflammation Control ...................................................................................................................... 933

Upkar Bhardwaj

Poly(e-caprolactone) Nanowire/fiber Arrays for Drug Delivery and Control of Cellular Interactions........................................................................................................................ 935

Sarah Tao

Preparation of Growth Factors-containing Chitosan-alginate Polyelectrolyte Complex Scaffold for Wound Regeneration ................................................................................ 937

Fwu-Long Mi

Sustained Release of Fibroblast Growth Factor from Chitosan-heparin Composite Artificial Extracellular Matrix ......................................................................................................... 939

Shin-Shing Shyu

Application of an Aqueous Ethylcellulose Dispersion in Multiple-Unit Pellet Systems ........................................................................................................................................... 941

Viena Dias

Development and Evaluation of Gastroretentive Floating Drug Delivery System of Acyclovir .......................................................................................................................................... 943

Ghanshyam Das Gupta

Development and Evaluation of Gastroretentive Floating Microspheres of Silymarin .......................................................................................................................................... 945

Ghanshyam Das Gupta

Development and Evaluation of Mucoadhesive Patches of Salbutamol Sulphate in the Effective Treatment of Asthma................................................................................................ 947

Rajeev Garg

Drug-polymer Interactions in Controlled Delivery Systems: Interactions of Metoprolol Tartrate with Eudragit RL in Films ............................................................................. 949

Bianca Glaessl

Investigation of the Relationship between Formulation Variables and Drug Release in Aqueous Ethylcellulose Coating ................................................................................ 951

Kurt Fegely

Iontophoretic Delivery of Minoxidil Sulfate for Topical Androgenic Alopecia Treatment ......................................................................................................................................... 953

Renata Lopez

Pharmacokinetics of Domperidone in Rabbits from Bioadhesive Buccal Dosage Form ................................................................................................................................................. 955

Harmik Sohi

Stent for Delivery of 1,3-Dipropyl-8-cyclopentyl xanthine (DPCPX) - A Signaling Pathway Specific Drug ................................................................................................................... 957

Eunah Kang

Topical Antimicrobial Cyanoacrylate Formulations.................................................................... 959Binoy (Ben) Bordoloi

Chemical Stability of Polymer-based In Situ Gelling Intramammary Formulations ................ 961Alany Raid G

Evaluation of Polysaccharide Beads as Potential Oral Vaccine Delivery Platforms ............... 963Alan Smith

LIPOMERS: Optimization of Lipid Concentration for Splenic Targeting .................................. 965Rajesh Patil

Preparation of Josamycin Loaded Floating Microspheres for Fish Farming ........................... 967Pushp Nepal

Design and Gamma-Scintigraphic Evaluation of a Floating and Pulsatile Drug Delivery System Based on an Impermeable Cylinder ................................................................. 969

Hao Zou

Gastro-intestinal Transit of Enteric Coated Mesalazine Products: Imaging by Use of Magnetic Marker Monitoring Technique................................................................................... 971

Maria Anschütz

In vivo tracking of Mesenchymal Stem Cells by MR Imaging .................................................... 973Hye Jung Choi

Intravascular Delivery and Sustained Release of Ultrasound Contrast Microbubbles Via Intraperitoneal Administration........................................................................ 975

Alexander Klibanov

New Technology for Non-Invasive Real-Time Imaging of Liposome by Positron-Emission Tomography ................................................................................................................... 977

Takeo Urakami

Peg-Based Block Copolymers As MRI Contrast Agent, Their Longitudinal Relaxivity and Micelle Formation .................................................................................................. 979

Kouichi Shiraishi

Pharmacokinetic Analysis of Hyaluronic Acid Derivative As A Drug Carrier Using Quantum Dots ................................................................................................................................. 981

Jiseok Kim

PLGA Microparticles Containing Gd-DTPA for Imaging ............................................................. 983Amber Doiron

Preparation of Iron Oxide Nanoparticles with Different Particle Sizes and Surface Potentials for Cell Labeling............................................................................................................ 985

Yasuhiko Tabata

Quantum Dots As Tool for the Long-term Imaging of Particulate Drug Delivery Systems ........................................................................................................................................... 987

Cornelia Rose

Sulfated Polysaccharides Enhance the Biological Activities of Transforming Growth Factor-ß3 (TGF-ß3) in Hydrogel for Neocartilage Formation ....................................... 989

Dae Gyun Woo

Terahertz Pulsed Imaging for Non-destructive Analysis of Hydration dynamics of Functional Coatings and Controlled Release Products.............................................................. 991

Yao-Chun Shen

The In-Vivo Behaviour Of Erodible Tablets: A Gamma Scintigraphic Study............................ 992Manish Ghimire

Characterization of Thermosensitive Chitosan-based Hydrogels by Electron Paramagnetic Resonance Spectroscopy ..................................................................................... 994

Hendrik Metz

D-optimal Formulation Designing of Controlled Release Microiparticle Based Depot Injections of Aripiprazole .................................................................................................... 996

Tushar Nahata

Encapsulation and Release of Plasmid DNA from Uniform PLGA Microspheres.................... 997Daniel Pack

Enzyme-Mediated Injectable Hydrogels Composed of Hyaluronic Acid-Green Tea Catechin Conjugates ...................................................................................................................... 999

Motoichi Kurisawa

Essential Oil from Zantoxyllum tingoassuiba Loaded into Multilamellar Liposomes Useful as Antibiotic and Antimicrobial Agent........................................................ 1001

Elaine Cabral-Albuquerque

Influence of Poly(lactide-co-glycolide) Type and Gamma Irradiation on the Betamethasone Acetate Release from in Situ Forming Systems ............................................ 1003

Hamid Mobedi

Injection Depot Delivery of Methyl Prednisolone Acetate Using Aqueous Suspension.................................................................................................................................... 1005

Javed Ali

Leuprolide Acetate Loaded In Situ Gel Forming System: In vitro / in vivo evaluation ...................................................................................................................................... 1007

Hamid Mobedi

Mechanism of Oxytocin Release from Pluronic® F127 Gel using USP Apparatus 3............. 1009Roderick Walker

Polysaccharide/Protein Self-Association for Protein Stability in Poly(lactide-co-glycolide) Microspheres; Lysozyme Release, Stability, in vivo Behavior and Biocompatibility ............................................................................................................................ 1011

Kun Na

RhGF-loaded Microspheres for the Treatment of Neurodegenerative Disorders .................. 1013Cunxian Song

Silk-Elastinlike Hydrogels for Controlled Adenoviral Gene Delivery ...................................... 1015Ramesh Dandu

Coatings for Enzyme Delivery in Animal Feed Applications.................................................... 1017Beth Fryksdale

Controlled Delivery Mosquito Larvicide Formulations: Testing and Evaluation ................... 1019Richard Levy

Mechanically Strong Nanoclay Crosslinked Hydrogels exhibiting pH and Temperature Sensitivity ............................................................................................................... 1021

Siddharthya Mujumdar

6-Mercaptopurine Microbubbles Drug Delivery: Preparation and In-vivo Studies ................ 1023Manish Umrethia

Biodegradable and Biocompatible Nanocapsules and Particles Prepared by the Miniemulsion Polymerisation ...................................................................................................... 1025

Ruth Schmid

Controlled Release of Proteasome Inhibitor from Biodegradable Nanoparticles for Myeloma Therapies....................................................................................................................... 1027

Gianny Rossini

Cytotoxicity of Perfluorocarbon-based Emulsion Oxygen Carriers ........................................ 1029Valerie Centis

Development of Co-encapsulated Nanoparticles of Ellagic Acid and Coenzyme Q10 (NanoCAPs) and Their Evaluation in Streptozotocin Induced Diabetic Rats ................. 1031

Venkat Ratnam Devdasu

Docetaxel Loaded Chitosan Nanocapsules for Cancer Therapy ............................................. 1033Victoria Lozano

Effect of pH on the Encapsulation of Buprenorphine HCl in Polylacide-co-glycolide......................................................................................................................................... 1035

Richard Graves

Encapsulation of the Nitric Oxide Donor Trans-[RuCl([15]aneN4)NO]Cl2 in Biodegradable Polymer by Double Emulsion Method .............................................................. 1037

Fabiana Oliveira

Formulation and Characterization of Microencapsulated Catalase ........................................ 1039Rodney Siwale

Formulation and Evaluation of Submicroscopic Carrier Systems of Moxifloxacin for Ocular Delivery ........................................................................................................................ 1041

Sanjay Motwani

Formulation and Ex-vivo Evaluation of Antisense Oligonucleotides to Nf-kB Encapsulated Albumin Microspheres in a Kidney Transplant Model ..................................... 1043

Sanjay Gayakwad

Formulation of Drug Loaded Nanoparticles from Low Molecular Weight Poly(L-Lactic Acid) by a Novel Electrospraying Technique ................................................................. 1045

Leena Peltonen

Loading Capacity of Beclomethasone Dipropionate in EPC Liposome Membranes ............ 1047Fernando Vasconcellos

Lower Critical Solution Temperature Phase Behavior (LCST) Study of Poly(organophosphazenes) ......................................................................................................... 1049

Sungsook Ahn

Multifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy............................................................................................................... 1051

Zhonggao Gao

Nanoparticle Encapsulated Droplets: A Novel Delivery System for Lipophilic Drugs .............................................................................................................................................. 1053

Clive Prestidge

New Concept Applying to Microencapsulation ......................................................................... 1055Younglim Chung

pH-Sensitive Liposome Based on trans-2-Aminocyclohexanols ............................................ 1057Ningrong Zhang

Photochemically Crosslinked Collagen Microspheres for Controlled Protein Release........................................................................................................................................... 1059

Cheuk Ming Chan

Polymer MW Determines Nanocarrier Characteristics to Reveal an Ideal Vehicle for Targeted Enzyme Delivery ..................................................................................................... 1061

Eric Simone

Positively Charged Polymeric Carriers for Amphotericin B Delivery...................................... 1063Satyanarayana Somavarapu

Preparation and Characterization of Bioadhesive Poly(methylmetacrylate) Nanoparticles Coated with Thiolated Chitosan ......................................................................... 1065

Mitra Seyed Moosavi

Volume 3

Preparation of Chitosan Nanoparticles Encapsulating Bovine Serum Albumin.................... 1067

Yilmaz Capan

Preparation of Polylacide-co-glycolide and Chitosan Hybrid Nanoparticles of Amifostine Using Coaxial Ultrasonic Atomizer with Solvent Evaporation ............................. 1069

Richard Graves

Release Characteristics of Novel Bioresorbable In-Situ Crosslinkable Self-Assembled nanoparticlces .......................................................................................................... 1071

Esmaiel Jabbari

Salt Addition Effects on the Poly(organophosphazenes) Thermothickening ........................ 1073Sungsook Ahn

Self-Assembled Collagen-Human Mesenchymal Stem Cell (hMSCs) Microspheres – Novel Bio-devices for Cell Delivery.......................................................................................... 1075

BP Chan

Temperature/pH-Induced Structural Variation of Shell Cross-linked Nanogels Using Poly(AAc-co-MEA)/PNIPAAm/mPEG Graft Copolymers ................................................ 1077

Wen-Hsuan Chiang

Treatment of Female Sexual Dysfunction Using Locally Applied Liposomal Sildenafil Citrate............................................................................................................................ 1079

Andreas Wagner

Utilizing Engineered Shape and Size-specific Nanoparticles for the Delivery of Biological Cargo............................................................................................................................ 1081

Ginger Rothrock

Liposomes with Hyaluronic Acid for Antitumor Drug Delivery................................................ 1083Luigi Cattel

Masking and Unmasking Targeting Ligands on Nanocarriers with Detachable PEG Coatings ................................................................................................................................ 1085

Efstathios Karathanasis

Microfabricated Components for Fully Implantable Microfluidic Drug Delivery to the Inner Ear .................................................................................................................................. 1087

Erin Leary Swan

N-Carboxymethyl Chitosan Coated Solid lipid Nanoparticles for Oral Delivery of Insulin............................................................................................................................................. 1089

Ramakrishna Sistla

Nano-Thermal Analysis of the Structural Properties of an HPMC/EC Polymer Blend .............................................................................................................................................. 1091

Andrew Parker

Optimization of TAT-peptide (TATp) Quantity on the Liposome Surface for Effective Intracellular Delivery of TATp-Conjugated PEG-Liposomes ................................... 1093

Shing-Ming Cheng

Physical stability of Nanostructured Lipid Carriers (NLC) in an o/w Urea Cream ................. 1095Jana Pardeike

Physical Stability of Rutin Nanosuspension Produced by High Pressure Homogenization ............................................................................................................................ 1097

Rachmat Mauludin

Physicochemical Characterization and Antioxidant Effects of Quercetinnano Particles ......................................................................................................................................... 1099

Tzu-Hui Wu

Physicochemical Characterizations of Lyophilized Ascorbyl Palmitate Nanosuspension ........................................................................................................................... 1101

Veerawat Teeranachaideekul

Physicochemical Evaluation of Alpha-lipoic Acid Encapsulated in Solid Lipid Nanoparticles (SLN)...................................................................................................................... 1103

Usawadee Sakulkhu

PLGA Docetaxel Nanoparticles: Preparation and In Vitro Evaluation..................................... 1105Farnaz Esmaeili

Preparation and Characterization of N-diethylmethyl Chitosan (DEMC) Nanoparticles Loaded with Insulin Using Both the Ionotropic Gelation and Polyelectrolyte Complexation Methods...................................................................................... 1107

Assal M.M. Sadeghi

Preparation and Characterization of PLGA Nanoparticles for Oral Delivery of Epigallocatechin Gallate .............................................................................................................. 1109

Pallab Datta

Preparation and Characterization of Self-Assembled Polyelectrolyte Nanocomplexes Based on Chitosan and Enoxaparin............................................................... 1111

Shirui Mao

Preparation of an Emulsion Formulation of Clopidogrel for Intravenous Administration............................................................................................................................... 1113

Rajeev Jain

Preparation of Calcium Phosphate Nanostructures Using Soft Chemical Route .................. 1115Ajeet Kumar

Preparation of Hydrophilic Antioxidant-Loaded Poly(vinyl alcohol) Nanoweb by Electrospinning and Its Wound Healing Effect .......................................................................... 1117

Won Seok Lyoo

Simultaneous Sizing of Nanoparticles by Individually Visualizing and Separately Tracking their Brownian Motion within a Suspension. ............................................................. 1119

Bob Carr

Stabilization of Chemically labile Actives Using Nanostructured Lipid Carriers (NLC)............................................................................................................................................... 1121

Aiman Hommoss

Stable Colloids of Poorly Soluble Drugs Prepared Using Layer-by-Layer Polymeric Coating of Drug Nanoparticles.................................................................................. 1123

Vladimir Torchilin

The Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing bFGF for Treatment of Neurodegenerative Diseases................................................................ 1125

Yilmaz Capan

Three-dimensional Nano/Micro Composite Scaffold by Mixing Electrospinning for Bone Tissue Engineering ............................................................................................................. 1127

Mira Jung

Transdermal Delivery of Cantilever Maltose Microneedle for Drug Customization............... 1130Yoshikazu Tobinaga

A Novel Multifunctional and Polymerizable Gene Carrier Mediated Efficient Transfection................................................................................................................................... 1132

Xuli Wang

Akt1 siRNA Delivery for Lung Carcinoma Using Poly (ester amine) ....................................... 1134Chong-Su Cho

Antisense GFP ODN-Hyaluronic Acid Conjugate/Protamine Nanocomplexes for Intracellular Gene Silencing......................................................................................................... 1136

Tae Gwan Park

Artificial Virion Nanocapsules for Gene Delivery ...................................................................... 1138Youqing Shen

Biochemical Investigation of Intracellular Transport of Polyethylenimine/DNA Polyplexes ..................................................................................................................................... 1140

Daniel Pack

Characterizations and lntracellular Distribution of Tumor Suppressor Gene (p53) Microparticles................................................................................................................................ 1142

Kadriye Ciftci

Charge Reversal Amphiphiles for DNA and siRNA Delivery .................................................... 1144Carla Hernandez Prata

Chitosan coated PLGA nanoparticles as carriers for antisense 2’-O-Methyl-RNA: evaluation of nanoplex stability and uptake into A549 lung cancer cells............................... 1146

Claus-Michael Lehr

Chitosan-coated PLGA Nanoparticles As a Flexible and Efficient Carrier for Antisense Oligonucleotides......................................................................................................... 1148

Noha Nafee

Chitosan-Mediated siRAN Delivery in Vitro: Effect of Polymer Molecular Weight and Salt Forms .............................................................................................................................. 1150

Praneet Opanasopit

Co-delivery of the Endosome-Disruptive Peptide INF 7 Improves Gene Delivery of Poly(N,N-dimethylaminoethyl methacrylate)-graft-polyethylenglycol (pdMAEMA-g-PEG) Copolymers ...................................................................................................................... 1152

Senta Uezguen

Effect of Counter Ion on the pH Sensitivity and Gene Transfection of Ortho Ester-Based Lipoplexes.......................................................................................................................... 1154

Xin Guo

Effect of Molecular Balance of Head-Tail type Polycation Vector to In Vitro Trasnfection Efficiency................................................................................................................. 1156

Atsushi Harada

Encapsultion and Cellular Delivery of Small-interfering Rna by Poly (ethylene Oxide)-poly (lactic Acid) Bilayer Polymersomes ...................................................................... 1158

Shenshen Cai

Encapsulation and Controlled Release of DNA from Silica Particles ..................................... 1160Linggen Kong

Enhanced Gene Delivery Using Disulfide-Crosslinked Polycations with Listeriolysin O Conjugates .......................................................................................................... 1162

Suna Choi

Folate Conjugated Poly(ester amine) for Lung Cancer Therapy ............................................. 1164Myung Haing Cho

Galactosylated Chitosan-graft-polyethylenimine as a Gene Carrier for Hepatocyte Targeting ........................................................................................................................................ 1166

You-Kyoung Kim

Gene Carrier for Enhanced Transfection Efficiency using Low Molecular Water Soluble Chitosan........................................................................................................................... 1168

Jae-Woon Nah

Gene Transfer Using Protamine Derivatives.............................................................................. 1170Li-Chien Chang

In Vitro Gene Transfer Efficiency of Urocanic Acid-modified Non-viral Polymeric Gene Transfer Agents................................................................................................................... 1172

Markus Elfinger

Introduction of Secondary and Tertiary Amines to Chitosan for Enhanced Delivery of Nucleic Acids ............................................................................................................. 1174

Bilal Ghosn

Investigation of in vitro/in vivo Correlates for Liposomal DNA Vaccines............................... 1176Sarah McNeil

Methylated N-(4-N,N-dimethylaminobenzyl) Chitosan for a Novel Effective Gene Carrier ............................................................................................................................................ 1178

Theerasak Rojanarata

Modified Polyallylamine Nanoparticles for Efficient Gene Delivery ........................................ 1180Atul Pathak

PEG-Detachable Polyplex Micelles Responding to Reduced Environment Based on PEG-b-Polyasparatamide Catiomers ..................................................................................... 1182

Seiji Takae

PEI / DNA / Alginate Polyplex As An Efficient In Vivo Gene Delivery System........................ 1184Ge Jiang

Physico-Chemical Characterization of the of Plasmid DNA and Nuclear Localization Signal Peptide Packed in Liposomes ................................................................... 1186

Maria Helena Santana

PLGA Nanoparticles for Gene Therapy – Waiving Complexity, Increasing Transfectivity................................................................................................................................. 1188

Jacob Gvili

Poly (lactide-co-glycolide)-polymethacrylate Nanoparticles for Gene Delivery..................... 1190Jagdish Singh

Polyethylenimine-based antisense oligodeoxynucleotide of interleukin-4 complex alleviate the interleukin-4 level in the murine model with allergic asthma ............................. 1192

Ji-Hye Seong

Preparation and Investigation of Octa(3-aminopropyl) Silsesquioxane L-Lysine Dendrimers as Nucleic Acid Carriers.......................................................................................... 1194

Todd Kaneshiro

SiRNA-Mediated Knockdown of EGFR Is Improved by Strategies Which Facilitate SiRNA-Endosomal Escape........................................................................................................... 1196

Sabrina Oliveira

Site-specific Delivery of Oligonucleotides to Hepatocytes ...................................................... 1198Lin Zhu

Supramolecular Control of Polyplex Decondensation and Cell Transfection: Efficacy of Amine and Threading Cyclodextrin on Biocleavable Polyrotaxanes................... 1200

Atsushi Yamashita

Synthesis, Characterization and Transfection of a Novel Folate-targeted Multipolymeric Delivery System for Gene Therapy................................................................... 1202

Nie Yu

Target-specific Intracellular Delivery of siRNA Using Degradable Hyaluronic Acid Nanogels ........................................................................................................................................ 1204

Hyukjin Lee

TATp-bearing Immunoliposome for Gene Delivery to Hypoxic Cardiomyocytes In Vitro ................................................................................................................................................ 1206

Young Tag Ko

The Development of p27kip1 Nanoliposome Gene Delivery System and Its Growth Inhibition Effects on Human Lung Caner Cells ......................................................................... 1208

Hongwei Zhang

The Effect of Remnant Cationic Dendrimers on RNA Purification .......................................... 1210Junghua Kuo

Thermo-sensitive Nano Gene Carriers Surface-modified with Pluronic Polymers................ 1212Jung Im Lee

Thiolated Chitosan Nanoparticles: Transfection Study in the CaCO-2 Transwell Cell Culture .................................................................................................................................... 1214

Ronny Martien

6-Month Administration of Oral Insulin at Lunchtime in Juvenile Type-1 DM Subjects on Basal Glargine Insulin and Pre-Breakfast and Pre-Dinner Regular Insulin............................................................................................................................................. 1216

Jaime Guevara-Aguirre

A Bioequivalent 120mg Pseudoephedrine HCl Extended-Release Monolithic Tablet.............................................................................................................................................. 1218

Stephen Turner

A Multiparticulate Drug Delivery System To Target Celecoxib To The Colon........................ 1220Manuel Guzman

A Novel Preparation Method for Rapidly Dissolving Biorelevant Media for Dissolution Testing – FaSSIF and FeSSIF Instant Powders..................................................... 1222

Kathrin Nollenberger

A Solid Dispersion Comprising Sibutramine Base Intended for Enhanced Solubilization ................................................................................................................................. 1224

HeeChul Chang

Acidified Solid Dispersions to Modify the Release Rates of Weak Bases.............................. 1226Madhav Vasanthavada

Adjustment of Desired Drug Release Patterns From Pellets Coated With Aqueous Ethylcellulose Dispersions: Importance of the Type of Core and Drug Solubility ................ 1228

Juergen Siepmann

Alcohol Influence on Drug Release - Concept for Rugged Formulations............................... 1230Brigitte Skalsky

Anionic Methacrylic Acid Copolymers as Release Enhancers ................................................ 1232Hema Ravishankar

Application Related Properties of a New Fast Dispersible Excipient...................................... 1234Karl Kolter

Assessment of Luminal Concentration of Drugs in GI Tract After Oral Administration............................................................................................................................... 1236

Takanori Goto

Assessment of Novel Liquid Crystalline Materials in the Oral Controlled Delivery of Lipophilic Compounds............................................................................................................. 1238

Tri-Hung Nguyen

Basic butylated methacrylate copolymers (Ph.Eur.) for stabilized Solid Solutions of Ibuprofen ................................................................................................................................... 1240

Andreas Gryczke

Bioavailability Study of Modified Amoxicillin/Clavulanate Therapeutic System ................... 1242Janez Kerc

Carboxymethyl High Amylose Starch – Chitosan Tablets Affording Colon Probiotic Delivery.......................................................................................................................... 1244

Carmen Calinescu

Characterization of Floating Kollidon® SR Matrix tablets ........................................................ 1246Sandra Struebing

Characterization of Permeation Processes of Coated Dosage Forms with Novel Polymers ........................................................................................................................................ 1248

Sandra Struebing

Coating of Pellets with Aqueous Dispersions Or Organic Solutions of Water-insoluble Polymers ....................................................................................................................... 1250

Mesut Ciper

Comparison of In Vitro Release Characteristics of Venlafaxine From Tablets Containing Different HPMC Polymers......................................................................................... 1252

Fusun Acarturk

Continuous Wavelet and DerivativeTransforms for the DissolutionTest of Levodopa - Benserazide Tablets ................................................................................................ 1254

Tanver Doganay

Controlled Release Study of 5-fluorouracil Loaded Chitosan/PEG Microparticles ............... 1256Chuen-Chang Lin

Correlating Dissolution Rates to Surface Properties Measured by Inverse Gas Chromatography ........................................................................................................................... 1258

Dan Burnett

Correlation between In Vitro Dissolution Profiles of Drugs from Enteric-coated Dosage Forms and In Vivo Drug Absorption ............................................................................. 1260

Ryoko Ogura

Curing Procedures for Matrix Tablets with EUDRAGIT® RS 30 D ........................................... 1262Brigitte Skalsky

Design of Biodegradable Nanoparticles of Atorvastatin Calcium (nanostatin) for Oral Delivery and Their Evaluation in High Fat Diet Fed Rats for Improved Efficacy with Reduced Toxicity ................................................................................................... 1264

Chandraiah Godugu

Design and Optimization of Mefloquine Hydrochloride Reverse Enteric Chitosan Microparticles (RE-Chi) for Bitter Taste Masking ...................................................................... 1266

Punit Shah

Design of a Monolithic Controlled Release Formulation of Ondansetron HCl for Oral Administration....................................................................................................................... 1268

Catherine Federici

Development and Characterization of a Solid Microemulsion Preconcentrate System for Oral Delivery of Poorly Water Soluble Drugs ......................................................... 1270

Abu Serajuddin

Development and Characterization of Carvedilol Fast Dissolving Tablet : Using Superdisintigrates and Solid Dispersion Technique. ............................................................... 1272

Shailesh Sharma

Development and Characterization Of Controlled Release Floating Pellets Of Clarithromycin ............................................................................................................................... 1274

Jessy Shaji

Development and Evaluation of New Floating Levodopa Sustained Release Minitablets ..................................................................................................................................... 1276

Goole Jonathan

Development of a Biorelevant Physiological Dissolution Stress Test Device ....................... 1278Grzegorz Garbacz

Development of a Novel Floating Pulsatile System for Chronotherapeutic Release of Aceclofenac............................................................................................................................... 1280

Vishal Patole

Development of an In-Vitro Dissolution Model for Prediction of In-Vivo Absorption of Poorly Water Soluble Drugs................................................................................ 1282

Saroj Vangani

Development of Clinical Dosage Forms for a Poorly Water-Soluble Drug II: Comparative Evaluation of Solid Dispersion, Solid Microemulsion Preconcentrate and Lipid-based Formulations..................................................................................................... 1284

Abu Serajuddin

Development of Mathematical Model for Predicting Formulation of Sustained Release Products .......................................................................................................................... 1286

Pirthi Pal Singh

Development of Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Oral Bioavailability Enhancement of Saquinavir ............................................................................... 1288

Deepa Patel

Development of a Sustained Release Tablet for Water Soluble Compounds ........................ 1290Ray Lo

Drug Abuse Resistant Controlled Release Using Egalet® Dosage Units .............................. 1292Pernille Hemmingsen

Drug Permeability Across a Phospholipid Vesicle Based Barrier: Barrier Structure Characterization and Effect of Agitation on Barrier Integrity and Drug Permeability................................................................................................................................... 1294

Gøril Eide Flaten

Drug Release Properties of Kollidon® VA 64/polyacrylic Acid Interpolymer Complexes for Oral Delivery ....................................................................................................... 1296

Ilshat Arislanov

Effect of Betacyclodextrin Complexation on Diffusion, Permeability and Bioavailability of Carbamazepine................................................................................................ 1298

Sarasija Suresh

Effect of Bio-relevant Media on the Properties of Hydroxypropyl Methyl Cellulose (HPMC) ........................................................................................................................................... 1300

Ian Hardy

Effect of Drug Solubility on the Properties of Hydroxypropyl Methyl Cellulose (HPMC) Tablets.............................................................................................................................. 1302

Ian Hardy

Effect of Formulation on Adinazolam Pharmacokinetics and Pharmacodynamics .............. 1304Viera Lukacova

Effect of Temperature on the In Vitro Transbuccal Permeation............................................... 1306Upendra Kulkarni

Effect of Thermodynamic Activities of the Unionized and Ionized Drug on Flux across Buccal Mucosa ................................................................................................................. 1308

Amit Kokate

Effervescent Floating Matrix System of DA 6034, a New Drug Candidate, for Gastroretentive Sustained Release............................................................................................. 1310

Sun Jang

Evaluation of Chemically Modified Starches as Sustained-Release Agents in Monolithic Tablets......................................................................................................................... 1312

Fernanda Onofre

Evaluation of the Ninhydrin Assay for Gabapentin Determination ......................................... 1314Karla LaPorte

Evaluation of the Effect of Hydroalcoholic Media of Textural and Rheological Characteristics of Hyrpomellose Matrices ................................................................................. 1316

Shahrzad Missaghi

Fast Dissolving Oral Strips Containing Garcinia Mangostana Husk Extract ......................... 1318Suchada Chutimaworapan

Fixed Dose Combination of Simvastatin and Ramipril ............................................................. 1320Jung Chul Joo

Formulation Development of a Novel Nanoparticle-based Therapeutic System for the Chemoprevention of Colon Cancer ..................................................................................... 1322

Naveen Kanthamneni

Formulation of Peppermint Oil in a Self-Emulsifying Drug Delivery System (SEDDS) for Oral Administration................................................................................................. 1324

Rainer Müller

Formulation optimization for improving in vitro dissolution and oral absorption of hydrophobic drugs ....................................................................................................................... 1326

CS Hsu

Glimepiride/L-arginine systems for higher hypoglycemic effects........................................... 1328Jeong-Soo Kim

Hydrodynamic Robustness of Hypromellose and Hydroxypropyl Cellulose Based Modified Release Matrix Systems .............................................................................................. 1330

Thomas Durig

Improved Solubility and Dissolution of Itraconazole by preparing Gelatin Based Microcapsules ............................................................................................................................... 1332

Dongxun Li

Improvement of Oral Absorption Behavior of Poorly Water-Soluble Drug Using SMEDDS: Pharmacokinetic Analysis and Prediction Based on GlTA Model ......................... 1334

Toshikiro Kimura

Improving Solubility, Dissolution and Bioavailability of Drugs Having Low Melting Points Using a Simple Technique ............................................................................................... 1336

Madhuri Newa

Influence of Ionic Interactions in Controlled Release Formulations of Water-Soluble Drug .................................................................................................................................. 1338

Kathrin Nollenberger

Improving the Dissolution Rate of Carbamazepine Using Melt Extrusion.............................. 1340Amit Kokate

In Silico Prediction of Drug Permeation Across Buccal Mucosa ............................................ 1342Herbert Hoyer

In Vitro and In Vivo Evaluation of a Patch System Based on Thiolated Polymers ................ 1344Wen Jen Lin

In Vitro In Vivo Study of Micropore-Controlled Release Tablet ............................................... 1346Manish Ghimire

In Vitro Characterisation of Radiolabelled Erodible Tablets .................................................... 1348Hema Ravishankar

Influence of Buffer Salts on Ammonioalkyl Methacrylate Copolymers .................................. 1350Volga Devabhaktuni

Insulin-coenzyme Q10 Coencapsulated PLGA Nanoparticles for Oral Delivery: A Better Regimen for Treatment of Diabetes Mellitus and Its Complications............................ 1352

Gaurav Sharma

The Influence of Different Types of Carbopol® on the Composition of Interpolyelectrolyte Complexes with Eudragit ® E Po Using Viscosity Measurements ............................................................................................................................... 1354

Tatiana Kabanova

Investigation of Changes in a Controlled Release Formulation upon Accelerated Aging .............................................................................................................................................. 1356

Andrew Parker

Investigation of Granule Microstructure using Micro-Computed Tomography and Raman Microscopy ....................................................................................................................... 1358

Andrew Parker

Large Polymeric Nanoparticles That Overcome The Mucus Barrier ....................................... 1360Samuel Lai

Limitations in the Ph-independent Extended Release of Weakly Basic Drugs from Eudragit RS 30D Coated Pellets .................................................................................................. 1362

Martin Koerber

Lymphatic Transport Contribution Towards the Systemic Exposure of Orally Administered pH-sensitive Nanoparticles (NP) Loaded with a Model Hydrophilic Peptidomimetic Drug .................................................................................................................... 1364

Rosa Pereira

Mathematical Model for Simulation and Control of Drug Release from Hydrophilic Matrices.......................................................................................................................................... 1366

Sandip Tiwari

Micro-environment Adjustment Improves the Release of Verapamil Hydrochloride from HPMC Based Mini-tablets.................................................................................................... 1368

Roderick Walker

Nanoparticles for Oral Insulin Delivery....................................................................................... 1370Kiran Sonaje

Nanosuspension of DA 6034, a New Drug Candidate, by pH-Dependent Solvent Diffusion Method for Enhancing Local Gastro-protective Effect............................................. 1372

Sun Jang

Nmr Studies of the Variation Due to Formulation in Evolving Pore Structures in Millimetre Sized Pellets ................................................................................................................ 1374

James Collins

Novel Carboxymethyl Starch Excipients for Oral Dosage Forms............................................ 1376Mircea Alexandru Mateescu

Novel Design of Three Oral Controlled Release Formulations of Phenylephrine HCl .................................................................................................................................................. 1378

Haiyan Zhang

Novel User-Friendly Dosage Forms of Choline ......................................................................... 1380Satishkumar Jain

Oral Bioavailability of Solutions vs Suspensions in Labrafil® 2125CS and In Vivo In Vitro Relations........................................................................................................................... 1382

Anette Mullertz

Oral Cyclosporine A Formulation for Chronic Immunosuppression: Implication of Nanotechnology in Reducing Nephrotoxicity ............................................................................ 1384

Jagdish Italia

Performance of A-PAMPA: A Three Lipid PAMPA System and Comparing PAMPA and CaCO-2 Permeability ............................................................................................................. 1386

Zeynep Teksin

Permeabilities of Polyethylene Glycol across Different Regions of Porcine Oral Mucosa ........................................................................................................................................... 1388

Tarun Goswami

Permeation Barriers to Two Lipophilic Cations in CaCO-2 Cell Monolayers ......................... 1390Ian G. Tucker

Pharmacokinetic and Pharmacodynamic Aspects of Gastro-retentive Metformin Pellets............................................................................................................................................. 1392

Jingshu Piao

Pharmacokinetic Evaluation of Extended Release and Immediate Release Formulations of Pramipexole ...................................................................................................... 1394

Dinesh Haswani

Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended-Release Tablet Formulation of Levodopa-Carbidopa in Healthy Volunteers ........................................ 1396

Peyman Moslemy

Pharmacokinetics of Gabapentin After Single and Repeated Dosing of Gabapentin Extended Release Tablets (G-ER) and Instant Release (IR) Tablets in Healthy Male and Female Volunteers.......................................................................................... 1398

Toufigh Gordi

Physical Characterization of Oleanolic Acid Nonsolvate and Solvates Prepared by Solvent Recrystallization ............................................................................................................. 1400

H. H. Y. Tong

Prandial Oral Insulin (Generex Oral-lynTM) in Adult Type-1 DM Subjects Receiving Basal s.c. Twice Daily Isophane Insulin (NPH) ........................................................ 1402

Jaime Guevara-Aguirre

Predictive Models for Drugs Exhibiting Negative Food Effects Based on their Biopharmaceutical Characteristics............................................................................................. 1404

Venugopal Marasanapalle

Preparation and Characterization of Piroxicam/Poloxamer Solid Dispersion Prepared by Melting Method ........................................................................................................ 1406

Hang Yu

Preparation and Evaluation of Self Microemulsifying Drug Delivery System(SMEDDS) of Valdecoxib. ................................................................................................ 1408

Vishwesh Joshi

Preparation and in Vitro Modulation of Chitosan Microsphere for Controlled Drug Delivery System ............................................................................................................................ 1410

Shital Lodha

Preparation and Optimization of Probucol Self-Emulsified Drug Delivery System (PBSEDDS) Applying Response Surface Methodology............................................................ 1412

Abdelazim Zaghloul

Prodrugs of 3-hydroxyphenazepam for Oral Delivery .............................................................. 1414Iryna Kravchenko

Proliposomal Formulations of Exemestane for Improved Oral Delivery ................................ 1416Praveen Hiremath

Prospects of using Honey as a Sustained Release Adjuvant in the Pharmaceutical Manufacture of Oral Dosage Formulations. ................................................... 1418

Musa Autamashih

Rheological Investigation of Mucoadhesive Interaction between Pectin and Mucin ............ 1420Nartaya Thirawong

Scalability Evaluation of Monolithic Controlled Release Gabapentin Formulations for Oral Administration................................................................................................................. 1422

Karla LaPorte

Solid Dispersions of Cilostazol Prepared Using Solution Enhanced Dispersion by Supercritical Fluids....................................................................................................................... 1424

Min-Soo Kim

Stability and Release Behavior of an Oral System Intended for Time-Based Colon Delivery of Insulin ......................................................................................................................... 1426

Mauro Serratoni

Sustained-release Formulations with Lipidic Excipients ......................................................... 1428Delphine Marchaud

Tabletting of Non-sticking Ibuprofen DC 85® with Different Disintegrants............................ 1430Karl Kolter

The Effect of Hypromellose as a Pore-Former on Drug Release from Aqueous Ethylcellulose Film-Coated Dipyridamole-Loaded Nonpareil Beads ...................................... 1432

Marina Levina

The Effect of Different Oils on the Absorption of a-Tocopherol in the Rat: Comparison of Palm Oil, Soybean Oil and Coconut Oil ........................................................... 1434

Tommy Julianto

The Effects of Pigments on Eudragit® NM 30 D Polymeric Dispersions and Formulations ................................................................................................................................. 1436

Dave Klimkowsky

The Influence of Fumed Silicon Dioxides on the Physical Aging and Drug Release Rate of EUDRAGIT® RS/RL 30 D Film-Coated Theophylline Pellets ....................................... 1438

Shawn Kucera

The Influence of Plasticizer Type and Level on Acid Resistance from Tablets Coated with an Aqueous Delayed Response Film Coaring System ........................................ 1440

Cara Young

The Influence of Solvent System on the Performance of Polyvinyl Acetate Phthalate (PVAP) Delayed Release Coating Systems............................................................... 1442

Kurt Fegely

The Stability of Ethylcellulose Film Coatings Containing PG alginate or Carrageenan .................................................................................................................................. 1444

Juergen Siepmann

Viscometry, a Method for Assessing Rate-Controlling Excipients ......................................... 1446Karla LaPorte

Sun Protection Factor (SPF) Increase Using Nanostructured Lipid Carriers (NLC) .............. 1448Aiman Hommoss

A New High Loading PEG for Drug Release .............................................................................. 1450Anna Mero

Biodistribution Study of Rifampin Bound to PLGA Nanoparticles Following Different Routes of Administration ............................................................................................. 1452

Svetlana Gelperina

Epirubicin-PEG Conjugate Releasing Nitric Oxide: In Vivo Evaluation ................................. 1454Gianfranco Pasut

Glipizide- Beta Cyclodextrin Inclusion Complexes for Dissolution and Bioavailability Enhancement ....................................................................................................... 1456

Vinay Batra

Glycopolymer Conjugates for Targeting Tumor Vascular Endothelium................................. 1458Ayelet David

In Vitro Investigations of a Permeation Enhancing Effect of Thiolated Chitosan on Oral Tobramycin Sulfate Uptake ................................................................................................. 1460

Juliane Hombach

In vivo Efficacy of Stabilized Doxorubicin Hydrazone-Conjugated Polymeric Micelles with Intracellular pH-Controlled Activation................................................................. 1462

Iulian Bobe

Novel Methods of Intracellular Delivery of ?F508-CFTR Correctors ....................................... 1463Luigi Cattel

Novel Multifunctional Polymeric Micelles for Targeted Drug Delivery.................................... 1465Xiao-Bing Xiong

Pharmacokinetic Behavior of Stabilized Doxorubicin Hydrazone-Conjugated Polymeric Micelles with Intracellular pH-Controlled Activation .............................................. 1467

Mitsunori Harada

Polymer Anticancer Drugs with Peptide Targeting ................................................................... 1468Martin Studenovsky

Synthesis and Characterization of Hyaluronic Acid-Peptide Conjugate for FPRL-1 Receptor......................................................................................................................................... 1470

Eun Ju Oh

Targetable Polymer - Antiangiogenic Drug Conjugates For Systemic Cancer Therapy .......................................................................................................................................... 1472

Anjan Nan

The Chemopreventive and Anticancer Activity of HPMA Copolymer-Fenretinide Conjugate In Vitro ......................................................................................................................... 1474

Alexander Malugin

The Impact of Free or N-(2-hydroxypropyl)methacrylamide (HPMA) Bound Doxorubicin on Surface Membrane Glycosylation: the Possible Role of CD43. ................... 1476

Lubomir Kovar

A Novel In Vitro Pulmonary Dissolution Testing Method for Controlled Release Inhalation Formulations ............................................................................................................... 1478

Yoen Ju Son

Characterization of Nebulized Liposomes: Preliminary Studies for Inhalative Application of a Liposomal Drug Delivery System for Vasoactive Intestinal Peptide ........................................................................................................................................... 1480

Brigitte Stark

Development of Pulmonary Administration System of Ciprofloxacin Incorporated Into Liposomesfor Treatment of Respiratory Intracellular Parasite Infections ...................... 1482

Kazuhiro Morimoto

Effects of Air Flow Rate and Relative Humidity on the Electrostatic Properties of Lactose Carriers for Dry Powder Inhalers .................................................................................. 1484

Keat Theng Chow

Effects of Rifampicin and DPPC Concentrations on the Aerodynamic Properties of PLGA Microspheres Prepared by Spray Drying Method ...................................................... 1486

Takehisa Nakajima

Evaluation of in vitro Methodologies used for Testing Controlled Release DPI Formulations ................................................................................................................................. 1488

Rania Salama

In Vitro and In Vivo Evaluation of Poly(ether-anhydride) Particles for Potential Treatment of Lung Cancer ........................................................................................................... 1490

Benjamin Tang

Nanosized Non-ionic Surfactant Vesicles (niosomes) for Enhanced Absorption of Low Molecular Weight Heparin Via the Pulmonary Route........................................................ 1492

Fakhrul Ahsan

Optimization of Jet Milling Conditions for Particle Size Reduction of Soft Materials......................................................................................................................................... 1494

Imran Saleem

Particles For Enhanced Aerosol Drug Delivery In Cystic Fibrosis .......................................... 1496Martin Donovan

Preparation and Characterization of Interleukin-2 Liposome for Pulmonary Administration............................................................................................................................... 1498

Nevin Celebi

Preparation and Properties of Inhalable Nanocomposite Particles ........................................ 1500Keishiro Tomoda

The Effect of Various Polymers on in Vivo Evaluation of Insulin/mannitol Spray Dried Powder for Inhalation ......................................................................................................... 1502

Morteza Rafiee-Tehrani

Design and Development of a Polymer-Blend Nanoparticle Drug Delivery System to Overcome Multidrug Resistance in Cancer .......................................................................... 1504

Lilian van Vlerken

Drug Delivery Systems In Pain Management ............................................................................. 1506Hamid Mobedi

Identification And Characterization Of Peptides Binding To A Novel Histone H1 Monoclonal Antibody By Phage Display .................................................................................... 1507

Kuei-Chen Chiang

Preparation and Characterization of Radiolabeled Antibodies for Targeted Therapy and Imaging .................................................................................................................... 1509

So-Young Lee

The Mechanism and Extent of Liposome Internalization by Macrophages ............................ 1511Elran Haber

Thiomers: Polymeric Efflux Pump Inhibitors in Oral Drug Delivery ........................................ 1513Andreas Bernkop-Schnürch

A Novel Approach to Surface Functionalization of Nanoparticles: II. Folic Acid Conjugated Nanoparticles ........................................................................................................... 1515

Yogesh Patil

A Novel Phage Identified Peptide Targets Nanocarriers to Gliomas of the Brain.................. 1517Abhiruchi Agarwal

Analysis of BiP Protein As a Targeting Molecule to Tumor Endothelium for Drug Delivery System ............................................................................................................................ 1519

Yasufumi Katanasaka

Anti-EGFR Peptide-Conjugated STEALTH Liposomes for Cancer Therapy........................... 1521Ken Huang

Bioadhesion of N-2(-Hydroxypropyl) Methacrylamide (HPMA) Copolymer-RGDfK Conjugates: Influence of Peptide Content ................................................................................ 1523

Mark Borgman

Bubble Dynamic Conditions for Drug Release from Pluronic Micelles .................................. 1525Mario Diaz de la Rosa

Characterization of Transferrin Conjugated Liposomes for Tumor Targeting Applications Using Bioimaging................................................................................................... 1526

Murali Divi

Chemoprevention of Tumor Metastasis by Liposomal ß-Sitosterol Intake ............................ 1528Hiromichi Imanaka

Chemosensitization of Multi-Drug Resistant Human Small Cell Lung Cancer Cells to Doxorubicin ............................................................................................................................... 1530

Imran Saleem

Coenzyme Q10 Loaded PLGA Nanoparticles for Oral Cancer Therapy: Assessment of Antioxidant’s Potential Against a Standard Chemotherapeutic Agent Paclitaxel. ........................................................................................................................... 1532

Dhawal Ankola

Differences in HSP Expression After the Treatment of Cancer Cell Lines with Different Polymeric Conjugates .................................................................................................. 1534

Ondrej Hovorka

Dual Function of Pluronic P85 in Treatment of Experimental Carcinoma in Rat ................... 1536Tianyi Krupka

Dual Specific Targeting of Tumor Angiogenesis....................................................................... 1538Deepali Vartak

Effects and Mechanisms of Glycocholic Acid on Modulation of Multidrug Resistance and Induction of Apoptosis in Caco-2 Cells .......................................................... 1540

Yu-li Lo

Effects of Carrier on Disposition and Antitumor Activity of Intraperitoneal Paclitaxel........................................................................................................................................ 1542

Jessie Au

Engineering Transferrin for Improved Drug Carrier Efficacy ................................................... 1544Bert Lao

Enhanced Efficiency of Transfection of Tumor Cells In Vivo by Using “Smart” pH-Sensitive TAT-Peptide-Modified PEGylated Liposomes........................................................... 1546

Amit Kale

Extracorporeal Elimination of Liposomes Used in Cancer Chemotherapy ............................ 1548Gerhard Putz

Folate Appended Liposomes for Enhanced Delivery of Doxorubicin to B16F10 Melanoma Cells ............................................................................................................................. 1550

Yashwant Gupta

Folate-Poly(ethylene glycol)-g-Polyethylenimine/ Retinoic Acid Nanoparticles for Receptor-mediated Tumor Targeting.......................................................................................... 1552

Mi-Kyong Yoo

Glutaraldehyde Improves Binding And Uptake Of RGD- Modified Erythrocytes By Angiogenic Endothelial Cells ...................................................................................................... 1554

Marcel Fens

In Vitro Efficacy of Core Shell Microparticle to Circumvent Efflux Transporter .................... 1556Kiran Dharmala

In Vitro Evaluation of Topical Iontophoretic Delivery of Doxorubicin..................................... 1558Renata Fonseca Vianna Lopez

Long-CirculatingPoly (EthyleneGlycol) - Coated Emulsionsto Target Solid Tumors ........................................................................................................................................... 1560

Joanna Rossi

Microemulsions for Topical Delivery of 5-Aminolevulinic Acid and its Hexil Ester in Photodynamic Therapy ............................................................................................................ 1562

Renata Fonseca Vianna Lopez

Multifunctional Micelles for Cancer Cell Targeting, Distribution Imaging, and Anticancer Drug Delivery ............................................................................................................. 1564

Ging-Ho Hsiue

Novel Amphiphilic Carriers for Folate Receptor Targeted Drug Delivery............................... 1566Shiladitya Bhattacharya

Novel Doxorubicin-Detergent Complexes for Improved Stealth Polymeric Nanoparticle Delivery ................................................................................................................... 1568

Xinyi Gu

Novel EPR-Independent Camptothecin Conjugate with Dual-phase Drug Release: A Blood Pool Effect? .................................................................................................................... 1570

Mikhail ("Misha") Papisov

Organ- and Cell-type Specific Delivery of Kinase Inhibitors .................................................... 1572Robbert Kok

Oxystress Induced Antitumor Therapeutics Via Tumor-targeted Delivery of PEG-Conjugated D-amino Acid Oxidase ............................................................................................. 1574

Jun Fang

Polymeric Magneto-Immunomicelles: Potential for Targeted MRI Imaging Probe ................ 1576Rishikesh Sawant

Polymeric-based pH-sensitive Immunoliposomes Specific to Human Myeloid Leukemic Cells .............................................................................................................................. 1578

Pierre Simard

Preclinical Application of Paclitaxel-Eluting Polyurethane Membrane for Bile Duct Stent ............................................................................................................................................... 1580

Seok Jeong

Prostate Cancer-Specific mAb 5D4 Significantly Enhances the Cytotoxicity of Doxorubicin-Loaded Liposomes Against Target Cells In Vitro................................................ 1582

Rishikesh Sawant

Pullulan/Deoxycholic Acid/Histidine Nanogels Responding to Extracellular Tumor pH; pH-Dependent Drug Release and In Vitro Cytotoxicity...................................................... 1584

Kun Na

Receptor-Mediated Gene Delivery by Folate-PEG-Baculovirus In Vitro and In Vivo ............. 1586You-Kyoung Kim

Synthesis and Targeted Radiotherapeutic Assessment of 188Re(V)DMSA Microspheres In Glioma ............................................................................................................... 1588

Jaya Shukla

Synthesis of Methotrexate-a-peptide Conjugates with Anti-parallel ß-Hairpin Structure ........................................................................................................................................ 1590

Phanidhara Kotamraj

Targeting and Bio-imaging of Solid Tumors Using RGD-fluorescent Liposomes ................. 1592Vinayagam Kannan

Transferrin Coupled Solid Lipid Nanoparticles Bearing Doxorubicin for Enhanced Delivery to MDA-MB-468 Breast Cancer Cells ........................................................................... 1594

Anekant Jain

Transferrin-Modified Procationic Liposomes as a New Carrier for the Delivery of Plasmid DNA.................................................................................................................................. 1596

Qin He

Ultrasonically-Assisted Drug Delivery in Rats Reduces Tumor Growth................................. 1598Bryant Staples

Useful Combination Therapy of Anti-angiogenic Agent with Chemotherapeutic Agents or Radionuclide Therapy for Cancer Treatment ........................................................... 1599

SunJu Choi

Author Index