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ii CONTENTS Page CONTENTS .......................................... ii CHAPTER 1 INTRODUCTION ............................ 1 1.1........................................... Back ground .................................... 1 1.2........................................... Obje ctives .................................... 2 CHAPTER 2 LITERATURE REVIEW ....................... 3 2.1........................................... Embr iology of Respiratory System .............. 3 2.2.1. Trachea, Bronchi, and Lungs .................. 6 2.2.2. Maturation of the Lungs ....................7 2.2.3. Surfactant Formation and Physiology ....................8 2.2........................................... Resp iratory Distress in Newborn ............... 11 2.2.1. Transient Tachypnea of the Newborn ...............14 2.2.2. Respiratory Distress Syndrome ................ 14

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2CONTENTSPageCONTENTS ........................................................................................................................................................................................................................... iiCHAPTER 1 INTRODUCTION .................................................................. 11.1..........................................................................................................Background ................................................................................................ 11.2..........................................................................................................Objectives .................................................................................................. 2CHAPTER 2 LITERATURE REVIEW ...................................................... 32.1..........................................................................................................Embriology of Respiratory System ............................................................ 2.2.1.!rac"ea# Bronc"i# and $ungs . . %2.2.2.&aturation of t"e $ungs ......... .'2.2.. Surfactant (ormation and P"ysiology . . )2.2..........................................................................................................Respiratory *istress in +e,born ............................................................... 112.2.1. !ransient !ac"ypnea of t"e+e,born.....................................1-2.2.2. Respiratory *istress Syndrome........................................ 1-2.2..&econium .spiration Syndrome........................................1/2.2.-.0nfections ......................................................... 1/2.2./.$ess 1ommon 1auses ...................................... 1%2...........................................................................................................Respiratory *istress Syndrome in +e,born .............................................. 1'2..1...............................................................................................Etiology .............................................................................................. 1)2..2...............................................................................................Pat"ology ............................................................................................ 2232.................................................................................................Pat"op"ysiology ................................................................................ 22..-...............................................................................................1linicalPresentation ............................................................................ 2-2../...............................................................................................*iagnosis ............................................................................................ 2/2..%...............................................................................................*ifferential *iagnosis ........................................................................ 2)2..'...............................................................................................Prevention ........................................................................................... 222..)...............................................................................................!reatment ........................................................................................... 222..2...............................................................................................1omplications ...................................................................................... CHAPTER 3 CASE REPORT ...................................................................... 35CHAPTER 4 DISCUSSION & SUMMARY ............................................... 434.1. *iscussion .................................................................................... -4.2. Summary ...................................................................................... --REFERENCES ............................................................................................... 45