Coniferae family

Presented by,Dr. Shenu P. KareemConiferae familyINTRODUCTIONConiferae is a large order of cone bearing plants.

The major group of alkaloids of Coniferae order is Terpene alkaloids.

MEDICINES BELONGING TO THE CONIFERAE FAMILYAbies canadensisAbies nigraCupressus australisCupressus lawsonianaJunipernus communisJunipernus verginianusLarix deciduaPinus cupressusPinus lambertiana

Pinus sylvestrisPix liquidaSabina juniperusSequoia sembervivensTaxus buccataTerebinthinaTerebinthina chiosThuja lobiiThuja occidentalis

MAJOR ALKALOIDS OF CONIFERAE FAMILYABIES CANADENSISPINENEBORNYL ACETATECANDINENETANIC ACIDJUNIPERNUS COMMUNISSABININOLPININECAMPHENETURPINOLPINUS LAMBERTIANAPINITOLPIX LIQUIDAOIL OF TURPENTINERESINSACETIC ACIDACETONEMETHYL ALCHOHOLSABINA JUNIPERNUSSABINOLSABINENECADINENETHUJONETAXUS BUCCATATAXINEN BISO TOXINE B

TEREBINTHINATERPENEMONOTERPENEBETE PINENEALPHA PINENETHUJA OCCIDENTALISTHUJONEPUNITANNIC ACIDTHUJETIC ACIDTANNINPINIPICRINERESINQUERCITRINQUERCETINVOLATILE OIL

THUJA OCCIDENTALISTHUJONEMajor alkaloid present in Thuja

Main action is GABA receptor antagonist.GABAGamma-Aminobutyric Acid

Required as an INHIBITORY NEUROTRANSMITTER to block the transmission of an impulse from one cell to another in the central nervous system, which prevents over-firing of the nerve cells.

Used for BRAIN METABOLISM Used as a SEXUAL STIMULANT because of its relaxing capabilities, as well as with prostate problems, since it also assists with the RELEASE OF SEX HORMONES.

REGULATION OF MUSCLE TONE. Nerve signals are constantly being fired in muscle tissue to stimulate it. This causes muscle to maintain it's strength. However if this nerve signal isn't regulated and inhibited occasionally, muscle tissue would hypertrophy. GABA blocks that nerve signal when appropriate. Precursor to sleep.

More concentrated in the hypothalamus region of the brain and is known to play a role in the overall functioning of the pituitary gland which regulates growth hormone synthesis, sleep cycles, and body temperature.

Needed by our BODY'S METABOLISM to break down food and make energy-rich molecules in cells.Our bodies are in a constant "on" state because of constant nerve impulses. Without GABA's causing an occasional "off" state their would be no resting state.INHIBITORY OR CALMING NEUROTRANSMITTER which can relieve tensions and anxieties.

HIGHER BRAIN FUNCTIONS SUCH AS VISUAL RECOGNITION OR UNDERSTANDING LANGUAGE REQUIRE THE PROCESSING OF INFORMATION IN THE BRAIN. This ability declines as we age. This decline appears to be due to a reduction in GABA in the brain.

SYMPTOMS IN RELATION TO THE ALKALOIDSREDUCED GABA ANXIETY

AnxietyDepressionFeelings of hopelessnessMood swingsSudden onset of phobias or fearsShort temperStress headacheGABA Reduced Low GH ACCUMULATION OF FAT IN WAIST AND HIP LINE

Reduced GABA INSOMNIA

Reduced GABA Brain metabolism altered No nutrition supply RAPID EXHAUSTION

Reduced GABA Unwanted firing of neurons No inhibitions MUSCLE TWITCHINGS AND EPILEPSY

Reduced GABA Reduced GH AGEING VERY FAST SKIN WRINKLED, DRY

Reduced GABA Prostatic problems HYPERTROPHYACTION OF OTHER ALKALOIDS IN THUJADIURETIC (Causing Increased Passing Of Urine)Frequent micturition. Desire sudden and uncontrollable.

SUDORIFICProfuse perspiration which is strong and sweetish

ANTIBACTERIAL AND ANTISEPTICIll effects of vaccination and gonnorhoeaEMMENAGOGUECopious and bright red menses

AROMATICPerspiration strong and sweetish.Sour smelling like honey sweat from genitals

TEREBINTHINIAE OLEUMALPHA AND BETA PINENESSpasmolytic and myorelaxantActivity on the smooth muscles of the intestine . These effects may explain their traditional use in the German and Polish traditional drugs for colic, diarrhea, cough and asthma. This antispasmodic activity would be due to the inhibition of the calcium channels.

tAnti InflammmatoryEnterocolitis, Stomatitis, Glossitis, Inflammation Of Kidneys, Urethritis, Metritis, Cystitis.

Regeneration Of Islets Of Langerhans Used in DM

Anticarcinogenic Cytotoxic on cancer cells Generalities- Cancerous affections Terebinthina (3)

Potent Diuretic Dropsy, Scanty suppressed, Passive

Bactericidal,Fungicidal,Insecticidal,Pesticidal Worms, Lumbricoids, Pustular eruptions, Urticaria

Analgesic activity Strangury, painful erections, Burning pain in the region of kidneys, Pulsative pain in skin, Drawing pain in the right kidney extending to hip.TURPENEA poisonous does of oil of turpentain causes a burning pain in the mouth ,throat and stomach followed by thirst,voomitting,diarrhoea,contracted pupils giddiness,drowsiness,cold skin excitement,cynosis,convulsion,coma and death.owing to its irritating action on the kiidney the patient complains of strangury and scanty dark urine,which contain bllod and albumin,and smell of violet.the persons show symptoms of anuria if large quantie taken.if applied to the skin oil of turpentain produce redsness and itching followed by vesicasionInhalation of turpentin vapour produce the irritation of eye,head ach,dizziness and irritation of respiratry passages are even chemical pneumonities(or) pulmonary oedemaSABINAEMMENAGOGUE Menses profuse and bright Discharge of blood between periods Haemorrhage partly clotted

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