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Conclusions Davis is a freely available data viewer that supports multiple simultaneous views of data with spatial and temporal dependencies. We illustrate the use of Davis here by comparing two models of the turtle visual cortex. Shown are direct views, parallel coordinate views of orderings, space time activity diagrams with overlays and KL caricatures [4, 5, 6]. The Davis website is http://vip.cs.utsa.edu/research/Davis/ index.html. Acknowledgements We are grateful to our collaborators on the turtle brain project, Philip Ulinski and Bijoy Ghosh, for sharing their models and insight. This work was partially supported by NIH (G12 RR13646) and NSF EIA-0217884, NSF-NIH collaborative research in neuroscience. References [1] J. M. Bower and D. Beeman, The Book of Genesis: Exploring Realistic Neural Models with the General Neural Simulation System, 2 nd Ed, Springer-Verlag, 1998. [2] Z. Nenadic, B. Ghosh, and P. Ulinski, Propagating waves in visual cortex: A large-scale model of turtle visual cortex, J. of Computational Neuroscience, 14(2):161-184, 2003. [3] W. Wang, B. Ghosh, and P. Ulinksi, Integrative physiology of subpial cells, submitted. [4] K. Robbins, M. Robinson and D. Senseman, Visualizing cortical Introduction Davis (Data Viewing System) is a general-purpose data viewer designed for the simultaneous display and comparison of dynamic data sets. Inspired by the need to explore data from imaging experiments and large computational models of the cerebral cortex, Davis allows scientists to study the detailed behavior of individual elements and the interaction of these elements to achieve cortical function. Davis provides direct views that animate activity over time. Davis also supports parallel coordinate latency visualizations, remapped space-time activity diagrams, and low dimensional-projections of correlated behavior that facilitate comparison of structure across data sets. We demonstrate Davis by comparing two versions of the NGU. Using Davis to Compare Neural Models CAJAL NEUROSCIENCE RESEARCH CENTER The University of Texas at San Antonio E. Pilipaviciute 1 , K. A. Robbins 1,3 , D. M. Senseman 2,3 1 Department of Computer Science 2 Department of Biology 3 Cajal Neuroscience Research Center University of Texas at San Antonio, San Antonio, TX 78249 NGU model of turtle visual cortex The NGU model [2] has 4 types of neurons (lateral, medial, horizontal and stellate neurons). LGN HH neurons deliver the input. A modified NGU model adds inhibitory subpial neurons [3]. The models are run under Genesis [1] using diffuse flash stimuli. Direct view comparison Neurons: Horizont al Latera l Media l Stella te LGN Subpia l Excitat ory: Inhibit ory: Original model in gray with magenta dot, modified model in black with red dot, t = 150 ms. 122 122 Original model Modified model Original model Modified model Low-dimensional projections Lateral Medial Stellate Gaba A AMPA NMDA Soma Voltage Space-time activity diagrams Half-height latency ordering for lateral voltage (original versus modified) Parallel coordinate latency view time line at 0.444 seconds Original model Modified model time line at 0.074 seconds Original model Modified model AMPA Soma voltage Gaba A NMDA Original model Modified model Lateral neurons Medial neurons time line at 0.341 seconds Original model Modified model Soma voltage Modified model Original model Davis interface is built automatically from user XML files

Conclusions Davis is a freely available data viewer that supports multiple simultaneous views of data with spatial and temporal dependencies. We illustrate

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Page 1: Conclusions Davis is a freely available data viewer that supports multiple simultaneous views of data with spatial and temporal dependencies. We illustrate

ConclusionsDavis is a freely available data viewer that supports multiple simultaneous views of data with spatial and temporal dependencies. We illustrate the use of Davis here by comparing two models of the turtle visual cortex. Shown are direct views, parallel coordinate views of orderings, space time activity diagrams with overlays and KL caricatures [4, 5, 6]. The Davis website is http://vip.cs.utsa.edu/research/Davis/index.html.

AcknowledgementsWe are grateful to our collaborators on the turtle brain project, Philip Ulinski and Bijoy Ghosh, for sharing their models and insight. This work was partially supported by NIH (G12 RR13646) and NSF EIA-0217884, NSF-NIH collaborative research in neuroscience.

References[1] J. M. Bower and D. Beeman, The Book of Genesis: Exploring Realistic Neural Models with the General Neural Simulation System, 2nd Ed, Springer-Verlag, 1998.[2] Z. Nenadic, B. Ghosh, and P. Ulinski, Propagating waves in visual cortex: A large-scale model of turtle visual cortex, J. of Computational Neuroscience, 14(2):161-184, 2003.[3] W. Wang, B. Ghosh, and P. Ulinksi, Integrative physiology of subpial cells, submitted.[4] K. Robbins, M. Robinson and D. Senseman, Visualizing cortical waves and timing from data, IEEE Visualization ‘2004, 401-408, 2004.[5] K. Robbins and D. Senseman, Extracting wave structure from biological data with application to responses in turtle visual cortex, J. Computational Neuroscience, 16:267-298, 2004.[6] K. Robbins, I. Grinshpan, K. Allen and D. Senseman, Synchronized views for exploring populations of neurons, Proc. SPIE (Papers selected from Visualization and Data Analysis 2004, Eds R. F. Erbacher, P. C. Chen, J. C. Roberts, M. T. Gröhn, K. Börner), 5295:235-245, 2004.

IntroductionDavis (Data Viewing System) is a general-purpose data viewer designed for the simultaneous display and comparison of dynamic data sets. Inspired by the need to explore data from imaging experiments and large computational models of the cerebral cortex, Davis allows scientists to study the detailed behavior of individual elements and the interaction of these elements to achieve cortical function. Davis provides direct views that animate activity over time. Davis also supports parallel coordinate latency visualizations, remapped space-time activity diagrams, and low dimensional-projections of correlated behavior that facilitate comparison of structure across data sets. We demonstrate Davis by comparing two versions of the NGU.

Using Davis to Compare Neural ModelsCAJAL

NEUROSCIENCE

RESEARCH

CENTER

The University of Texas at San Antonio E. Pilipaviciute1, K. A. Robbins1,3, D. M. Senseman2,3

1Department of Computer Science 2Department of Biology 3Cajal Neuroscience Research CenterUniversity of Texas at San Antonio, San Antonio, TX 78249

NGU model of turtle visual cortexThe NGU model [2] has 4 types of neurons (lateral, medial, horizontal and stellate neurons). LGN HH neurons deliver the input. A modified NGU model adds inhibitory subpial neurons [3]. The models are run under Genesis [1] using diffuse flash stimuli.

Direct view comparison

Neurons:Horizontal

Lateral Medial

Stellate

LGN

Subpial

Excitatory:

Inhibitory:

Original model in gray with magenta dot, modified model in black with red dot, t = 150 ms.

122

122

Ori

gin

al m

od

el

Mo

dif

ied

mo

del

Original model Modified model

Low-dimensional projectionsLateral Medial Stellate

Gab

a AA

MP

AN

MD

AS

om

a V

olt

age

Space-time activity diagrams

Half-height latency ordering for lateral voltage (original versus modified)

Parallel coordinate latency viewtime line at 0.444 seconds

Original model Modified model

time line at 0.074 seconds

Original model Modified model

AM

PA

So

ma

vo

lta

ge

Ga

ba

AN

MD

A

Original model Modified model

Lateral neurons Medial neurons

time line at 0.341 seconds

Original model Modified model

So

ma

vo

lta

ge

Modified model

Original model

Davis interface is built automatically from user XML files