Computing in the Life SciencesComputing in the Life Sciences

Simon MercerProgram ManagerExternal Research & ProgramsMicrosoft Research

Simon MercerProgram ManagerExternal Research & ProgramsMicrosoft Research

“It would appear that we have reached the limits of what is possible to achieve with computer technology, although one should be careful with such statements, as they tend to sound pretty silly in five years.”

John von Neumann, 1949

The future can take even very smart people by surpriseThe future can take even very smart people by surprise

Basic Research Agility Basic Research Agility

Basic research group allows a company like Microsoft to respond more rapidly to change

Research provides a reservoir of technology, expertise and people that can be quickly brought to bear:

New technologies

New competitors

New business models

Basic research group allows a company like Microsoft to respond more rapidly to change

Research provides a reservoir of technology, expertise and people that can be quickly brought to bear:

New technologies

New competitors

New business models

Augmenting In-House ResearchAugmenting In-House Research

In-House ResearchCentral to Company InterestsComplete IP ownershipExpensive

External ResearchCloser to an “Open Innovation” modelCan explore long term goals and those peripheral to the current businessRisk profile can be higher – Failure is an Option

In-House ResearchCentral to Company InterestsComplete IP ownershipExpensive

External ResearchCloser to an “Open Innovation” modelCan explore long term goals and those peripheral to the current businessRisk profile can be higher – Failure is an Option

Henry Chesbrough - Open Innovation: The New Imperative for Creating and Profiting from Technology , Harvard Business School Press, 2003

“There are things that other people get to before us. We avoid that a lot by working well with the universities. We have way bigger university outreach program than any company and that's worldwide, universities in Europe, India, China.

The US universities are where we get the most out of that, but we want to make sure we're doing it everywhere.”

– Bill Gates, Time Magazine interview, March 2006

Collaboration ModelCollaboration Model

CentersInstitutesCentersInstitutes

ProjectsProjects

Workshops & RFPsWorkshops & RFPs Explore Ideas

Validate Directions

Accelerate Research

Supporting Programs – Faculty Summit, Ph.D. fellowships, New Faculty Awards,

Ecosystem engagements

Supporting Programs – Faculty Summit, Ph.D. fellowships, New Faculty Awards,

Ecosystem engagements

ActivitiesActivities

eScience Workshops 2004/560+ speakers

120+ attendees

Seven countries represented

eScience Workshop 2006 (TBC)

eResearch Institute at Queensland University of Technology (TBC)

eScience Workshops 2004/560+ speakers

120+ attendees

Seven countries represented

eScience Workshop 2006 (TBC)

eResearch Institute at Queensland University of Technology (TBC)

ProjectsProjects

37 projects in 9 countries

Bioinformatics

Smart Clients for eSciencesWorkbenches that handle scientific data acquisition, management, integration, access, and visualization

Web services that unlock valuable data sets

37 projects in 9 countries

Bioinformatics

Smart Clients for eSciencesWorkbenches that handle scientific data acquisition, management, integration, access, and visualization

Web services that unlock valuable data sets

Computational ScienceComputational Science

Rakesh Nagarajan

Washington University

Siteman Cancer Center

Function Express Gold: A Function Express Gold: A caBIG Grid-aware Microarray caBIG Grid-aware Microarray Analysis ApplicationAnalysis Application

The cancer Biomedical Informatics Grid (caBIG) develops applications to facilitate individual steps involved in microarray analysis, but there is no single application that leverages these tools in a user-friendly graphical interface.  We will develop a grid-aware microarray analysis application producing results which may be visualized using a rich set of viewers such as literature-based gene networks, pathways browsers, graphs, and heat maps. This tool will serve as a powerful means to identify previously underappreciated pathways for potential new targeted therapeutics. 

Computational ScienceComputational Science

May Wang

Georgia Institute of Technology

The Wallace H. Coulter Department of Biomedical Engineering

Advanced Biomedical Advanced Biomedical Computing Systems for Computing Systems for Cancer ResearchCancer Research

In collaboration with Winship Cancer Institute, the group is developing a computation-based cancer research system. The system consists of databases, cluster-based computing, and immersive visualization. With this system, they will be able to integrate large amounts of genomic, proteomic, and molecular/organ imaging data obtained from cultured cancer cells, clinical tissue specimens, and solid tumors to analyze and guide clinical cancer research.

Computational ScienceComputational Science

Furrukh Khan

The Ohio State University

OR-EyeOR-Eye

A secure, reliable, and scalable A secure, reliable, and scalable distributed application that enables distributed application that enables remote remote reviewing of the OR component reviewing of the OR component of the pre-recorded of the pre-recorded electronic electronic anesthesia record anesthesia record from any location from any location where access to the Intranet/Internet is where access to the Intranet/Internet is available.available.

OR-Eye is now a fully developed, OR-Eye is now a fully developed, tested, and piloted product.tested, and piloted product.

OR-Eye2 is designed to completely OR-Eye2 is designed to completely replace the paper based anesthesia replace the paper based anesthesia record with an electronic version.record with an electronic version.

Computational ScienceComputational Science

Keyuan Jiang

Purdue University, Calumet

Information Systems and Computer Programming

The Gateway to Biological The Gateway to Biological PathwaysPathways

Developing a Web application called “The Gateway to Biological Pathways” to aggregate and unify the existing pathway databases and provide Web services for querying the aggregated datasets based upon the open standard for pathway data interchange BioPAX Level 1.

Computational ScienceComputational Science

Beth Plale

Indiana University at Bloomington

Computer Science

Web Service Access to Web Service Access to Streaming NEXRAD Level II Streaming NEXRAD Level II Radar DataRadar Data

Linked Environments for Atmospheric Discovery (LEAD), an NSF funded large scale cyberinfrastructure for severe storm forecasting, aims to improve access through a grid service architecture to enable access to data products, services, and processes for the severe storm researcher and educator.

Computational ScienceComputational Science

Tanya Berger-Wolf

University of Illinois at Chicago

Electrical Engineering and Computer Science

Computational Tools for Computational Tools for Population BiologyPopulation Biology

An intrinsic characteristic of societies is their continual change, yet few analysis methods are explicitly dynamic. Our goal is to develop a novel conceptual and computational framework to accurately describe the social context of an individual at time scales matching changes in individual and group activity. Finding patterns of social interaction within a population has applications from epidemiology and marketing to conservation biology and behavioral ecology.

Computational ScienceComputational Science

Benjamin Bederson Aaron Clamage

University of Maryland

Human-Computer Interaction Lab

Piccolo.NET Piccolo.NET

General purpose toolkit, useful for Information Visualization studies, Zooming User Interfaces, and other dynamic UI projects. Fully-accelerated through managed DirectX 9. For Mobile Devices, developers can use PocketPiccolo.NET, built on the .NET Compact Framework.

Computational ScienceComputational Science

Greg Quinn

University of California at San Diego

San Diego Supercomputer Center (SDSC)

Notebook ProjectNotebook Project

The Notebook application is a client-side data repository, collaboration environment, and smart client for SOAP-based Web services. The application is designed to store data from Internet Web sessions and also enables researchers to annotate data locally.

Computational ScienceComputational Science

Jason Kelly

Massachusetts Institute of Technology

Biological Engineering

iCampus: OpenWetWareiCampus: OpenWetWare

OpenWetWare (http://openwetware.org) is an effort to promote the sharing of information, know-how, and ideas among researchers and groups who are working in biology, biological engineering, and related disciplines. By providing a user-friendly editing interface (a wiki), the site provides a place for researchers to organize information and to collaborate with other community members. As of May, 2006, more than 50 academic labs from 25 institutions have joined the OpenWetWare community.

Synthetic Biology RFPSynthetic Biology RFP

“Design and fabrication of biological components and systems that do not already exist in the natural world”

“Re-design and fabrication of existing biological systems”

www.syntheticbiology.org

Synthetic Biology offers:

Great potential

Fertile collaboration

“Design and fabrication of biological components and systems that do not already exist in the natural world”

“Re-design and fabrication of existing biological systems”

www.syntheticbiology.org

Synthetic Biology offers:

Great potential

Fertile collaboration

http://research.microsoft.com/compsci/http://research.microsoft.com/compsci/

© 2006 Microsoft Corporation. All rights reserved.Microsoft, Windows, Windows Vista and other product names are or may be registered trademarks and/or trademarks in the U.S. and/or other countries.The information herein is for informational purposes only and represents the current view of Microsoft Corporation as of the date of this presentation.Because Microsoft must respond to changing market conditions, it should not be interpreted to be a commitment on the part of Microsoft,and Microsoft cannot guarantee the accuracy of any information provided after the date of this presentation.MICROSOFT MAKES NO WARRANTIES, EXPRESS, IMPLIED OR STATUTORY, AS TO THE INFORMATION IN THIS PRESENTATION.