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ANTIBIOTIC
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Compliance of manufacturers of
AST materials and devices with
EUCAST guidelines
• Data are based on questionnaires to manufacturers of materials and
devices for antimicrobial susceptibility testing.
• The tables will be updated when manufacturers report changes
(contact [email protected]).
• The accuracy of data in these tables is not verified by EUCAST and
the inclusion of any materials or devices does not indicate
endorsement by EUCAST.
Last updated 10 March 2016
Manufacturer Disks available MH-F plates available
Abtek All except ceftobiprole 5 µg and
ceftolozane-tazobactam 30-10 µg No
BD All except ceftobiprole 5 µg and
ceftolozane-tazobactam 30-10 µg Expected 2016
Bioanalyse All except ceftaroline 5 µg, ceftobiprole 5
µg and ceftolozane-tazobactam 30-10 µg No
Bio-Rad All except ceftobiprole 5 µg Yes
bioMérieux No disks marketed Yes
I2a All except ceftaroline 5 µg
and ceftobiprole 5 µg No
Liofilchem All except ceftolozane-tazobactam
30-10 µg (expected April 2016) Yes
MAST Group All except ceftobiprole 5 µg No but supply β-NAD supplement
Thermo Fisher Scientific (Oxoid)
All except ceftobiprole 5 µg,
ceftolozane-tazobactam 30-10 µg and
ticarcillin-clavulanic acid 75-10 µg
Yes
Rosco All (Neo-Sensitabs) No
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
EUCAST disk diffusion method
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
Automated systems for reading antimicrobial
susceptibility testing plates
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
Manufacturer System
EUCAST
breakpoints
implemented
EUCAST Expert
Rules
implemented
EUCAST terminology
implemented
S≤ R> - IE
Bio-Rad OSIRIS/ADAGIO Yes
Yes.
There are additional
rules but EUCAST
rules have priority.
Yes Yes Yes Yes
Giles Scientific BIOMIC V3 Yes Yes.
No exceptions Yes Yes Yes Yes
I2a
SIRSCAN:
2000
2000 automatic
Micro
Yes
Yes.
There are additional
rules but none
should be contrary
to EUCAST rules.
Yes Yes Yes Yes
Synbiosis -
Division of
Synoptics
ChromaZona Yes
Yes.
EUCAST rule
number displayed.
Yes Yes No No
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
Gradient tests: Etest (bioMérieux)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
Manufacturer Agents in EUCAST tables but
not available Agents validated for MH-F
bioMérieux Amoxicillin-clavulanic acid (fixed
2 mg/L clavulanic acid)*, **
Ampicillin-sulbactam (fixed 4
mg/L sulbactam)*, **
Cefadroxil
Cefalexin
Cefazolin
Ceftibuten
Ceftobiprole
(available for resaerch use only)
Ceftolozane-tazobactam
(expected 2016)
Oritavancin
Roxithromycin
Tedizolid
Ticarcillin
Ampicillin
Amoxicillin
Benzylpenicillin
Cefaclor
Cefepime
Cefixime
Cefotaxime
Cefpodoxime
Ceftriaxone
Cefuroxime
Doripenem
Ertapenem
Imipenem
Meropenem
Chloramphenicol
Ciprofloxacin
Levofloxacin
Moxifloxacin
Ofloxacin
Azithromycin
Clarithromycin
Erythromycin
Clindamycin
Doxycycline
Minocycline
Tetracycline
Tigecycline
Teicoplanin
Vancomycin
Daptomycin
Linezolid
Nitofurantoin
Rifampicin
Trimethoprim
Trimethoprim-sulfamethoxazole
(not for H. influenzae and M. catarrhalis)
*Gradient tests with the agent:inhibitor in a 2:1 ratio are not acceptable using EUCAST methods and breakpoints
** Expected during 2014
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
Gradient tests: MIC Test Strip (Liofilchem)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
Manufacturer Agents in EUCAST tables
but not available Agents validated for MH-F
Liofilchem Cefadroxil
Cefalexin
Roxithromycin
Telithromycin
Ticarcillin
Amoxicillin
Amoxicillin-clavulanic acid
(fixed 2 mg/L clavulanic acid)*
Ampicillin
Ampicillin-sulbactam
(fixed 4 mg/L sulbactam)*
Azithromycin
Benzylpenicillin
Cefaclor
Cefepime
Cefixime
Cefotaxime
Cefpodoxime
Ceftaroline
Ceftriaxone
Cefuroxime
Cephalothin
Chloramphenicol
Ciprofloxacin
Clarithromycin
Clindamycin
Doripenem
Doxycycline
Ertapenem
Erythromycin
Imipenem
Levofloxacin
Linezolid
Meropenem
Minocycline
Moxifloxacin
Ofloxacin
Rifampicin
Teicoplanin
Tetracycline
Trimethoprim-sulfamethoxazole
Vancomycin
*Gradient tests with the agent:inhibitor in a 2:1 ratio are not acceptable using EUCAST methods and breakpoints
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
Gradient tests: M.I.C.Evaluator
(Thermo Fisher Scientific)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
Manufacturer Agents in EUCAST tables but not available Agents validated for MH-F
Thermo Fisher
Scientific (Oxoid)
Amoxicillin-clavulanic acid
(fixed 2 mg/L clavulanic acid)*
Ampicillin-sulbactam
(fixed 4 mg/L sulbactam)*
Azithromycin
Aztreonam
Cefaclor
Cefadroxil
Cefalexin
Cefazolin
Cefepime
Cefixime
Cefoxitin
Cefpodoxime
Ceftibuten
Ceftobiprole
Ceftolozane-tazobactam
Cefuroxime
Chloramphenicol
Clarithromycin
Colistin
Dalbavancin
Doripenem
Doxycycline
Ertapenem
Fosfomycin
Fusidic acid
Mecillinam
Minocycline
Moxifloxacin
Mupirocin
Nalidixic acid
Netilmicin
Nitrofurantoin
Norfloxacin
Ofloxacin
Oitavancin
Piperacillin
Piperacillin-tazobactam
Quinupristin-dalfopristin
Rifampicin
Roxithromycin
Spectinomycin
Streptomycin
Tedizolid
Telavancin
Telithromycin
Ticarcillin
Ticarcillin-clavulanate
Tobramycin
Trimethoprim
Trimethoprim-sulfamethoxazole
Amoxicillin
Ampicillin
Benzylpenicillin
Oxacillin
Cefotaxime
Ceftazidime
Ceftaroline
Levofloxacin
Amikacin
Teicoplanin
Vancomycin
Erythromycin
Tetracycline
Tigecycline
Linezolid
*Gradient tests with the agent:inhibitor in a 2:1 ratio are not acceptable using EUCAST methods and breakpoints
EUCAST terminology
implemented
In computer
database
S ≤ Yes
R > No (R ≥)
- Yes
IE Yes
In reports
S ≤ Yes
R > Yes (≥ converted to R >)
- Yes (MICs reported for agents with no EUCAST breakpoints)
IE Yes (MICs reported for agents with no EUCAST breakpoints)
EUCAST Expert Rules
implemented
All rules incorporated. There are additional rules but EUCAST rules have priority.
EUCAST organism groups
with no test in the system
H. influenzae
M. catarrhalis
N. meningitidis
N. gonorrhoeae
Gram-negative anaerobes
Gram-positive anaerobes
Agents in EUCAST tables
but not available in the
system
Ampicillin-sulbactam (fixed 4 mg/l sulbactam)*
Ceftobiprole
Ceftolozane-tazobactam
Agents available but
EUCAST breakpoints not
implemented in the system
Rifampicin (Staphylococcus spp. cannot be reported susceptible)
Trimethoprim (Enterococcus spp. cannot be reported susceptible)
Trimethoprim-sulfamethoxazole (Enterococcus spp. cannot be reported susceptible)
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
Phoenix/EpiCenter automated system (BD)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
*Tests with the agent:inhibitor in a 2:1 ratio are not acceptable using EUCAST methods and breakpoints
EUCAST terminology
implemented
In computer
database
S ≤ Yes
R > Yes
- No
IE No
In reports
S ≤ Yes
R > Yes
- Most ”-” do not have interpretations reported
IE No
EUCAST Expert Rules
implemented
Yes. There are other rules in the system but EUCAST rules take precedence for EUCAST
panels. All rules can be customized by user.
EUCAST organism groups
with no test in the system
M. catarrhalis
Pasteurella
N. meningitidis
N. gonorrhoeae
Gram-negative anaerobes
Gram-positive anaerobes
Agents in EUCAST tables
but not available in the
system
Doxycycline
Roxithromycin
Telithromycin
Dalbavancin
Oritavancin
Tedizolid
Ampicillin-sulbactam (fixed 4 mg/l sulbactam)*
Amoxicillin-clavulanic acid (fixed 2 mg/l clavulanic acid)*
Ceftobiprole
Ceftolozane-tazobactam
All agents for anaerobes
Agents available but
EUCAST breakpoints not
implemented in the system
Chloramphenicol
Fusidic acid
Cefuroxime
Tigecycline (Gram-positive organisms)
Rifampicin
Trimethoprim
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
MicroScan automated system
(Beckman Coultier Diagnostics)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
*Tests with the agent:inhibitor in a 2:1 ratio are not acceptable using EUCAST methods and breakpoints
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
VITEK 2 automated system (bioMérieux)
*Tests with the agent:inhibitor in a 2:1 ratio are not acceptable using EUCAST methods and breakpoints
S ≤
R >
-
IE
S ≤
R >
-
IE
EUCAST Expert Rules
implemented
Gram-negative anaerobes C. jejuni and coli
Gram-positive anaerobes Corynebacterium spp.
H. pylori M. tuberculosis
L. monocytogenes
Cefuroxime (S. pneumoniae )
Dalbavancin
Daptomycin
Doxycycline (S. pneumoniae )
ICR (S. pneumoniae, Viridans group, Strep. Gr. C & G)
Minocycline (S. pneumoniae )
Oritavancin
Tedizolid
Telavancin
Trim-sulfa (Enterococcus spp.)
Ofloxacin (S. pneumoniae )
Streptomycin (Enterococcus spp.)
Antifungals
All agents with P. multocida
Benzylpenicillin (CoNS)
Cefoxitin screen (S. saprophyticus and S.
pseudintermedius)
Cefpodoxime (S. pneumoniae)
Ceftolozane-tazobactam (expected during 2016)
(Staphylococcus spp. and Enterococcus spp.)
uncomplicated UTI breakpoints (Enterobacteriaceae)
Acinetobacter spp.)
Agents available but EUCAST
breakpoints not implemented in
the system
Netilmicin (Staphylococcus spp.)
Trimethoprim (Enterococcus spp. and group B streptococci)
Amoxicillin-clavulanic acid (fixed 2 mg/l clavulanic acid)*
Doripenem (Enterobacteriaceae, Pseudomonas spp.,
Ciprofloxacin (Salmonella spp. and Enterococcus spp.)
Levofloxacin (Enterococcus spp.)
Norfloxacin (Enterococcus spp.)
Agents in EUCAST tables but not
available in the system
Azithromycin
Roxithromycin
Ampicillin-sulbactam (fixed 4 mg/L sulbactam) *
Phenoxymethylpenicillin
Cefadroxil
Ceftobiprole
Ceftibuten
Cefepime (S. pneumoniae)
Yes
All applicable rules dealing with intrinsic resistance, therapeutic interpretation and deduction are implemented beginning with
software version V2S 5.03 (2011) . There are additional rules but none should be contrary to EUCAST rules in this software version.
EUCAST organism groups with
no test in the system
H. influenzae
M. catarrhalis
N. meningitidis
N. gonorrhoeae
EUCAST terminology
implemented
In computer database
Yes
Yes
Yes
Yes
In reports
Yes
Yes
Yes
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
Sensititre (Thermo Fisher Scientific)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
EUCAST terminology
implemented
In computer
database
S ≤ Yes
R > Yes
- Yes
IE Yes
In reports
S ≤ Yes
R > Yes
- Yes
IE Yes
EUCAST Expert Rules
implemented
All EUCAST rules are implemented in software version 3.3 (2014). There are additional rules,
but these rules are inactivated in the EUCAST setting.
EUCAST organism groups
with no test in the system
N. gonorrhoeae
Agents in EUCAST tables
but not available in the
system
All agents available
Agents available but
EUCAST breakpoints not
implemented in the system
All agents for yeasts and molds
EUCAST terminology
implemented
In computer
database
S ≤ Yes
R > Yes
- Yes
IE No
In reports
S ≤ Yes
R > Yes
- Yes (MICs reported for agents with no EUCAST breakpoints)
IE No (MICs reported for agents with no EUCAST breakpoints)
EUCAST Expert Rules
implemented
All EUCAST rules are implemented. There are additional rules in the software. Our rules can be
customized by the user.
EUCAST organism groups
with no test in the system
N. gonorrhoeae
Agents in EUCAST tables
but not available in the
system
Ceftolozane-tazobactam (expected during 2016)
Agents available but
EUCAST breakpoints not
implemented in the system
All agents for molds.
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
MICRONAUT (MERLIN Diagnostika GmbH)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
EUCAST terminology
implemented
In computer
database
S ≤ Yes
R > Yes
- Yes (I)
IE Yes
In reports
S ≤ Yes
R > Yes
- Yes (I)
IE Yes
EUCAST Expert Rules
implemented
EUCAST rules are implemented in software version 20151105 (2015). There are additional
rules in the software. The rules can be customized by the user.
EUCAST organism groups
with no test in the system
Gram-positive anaerobes
N. gonorrhoeae
Gram-negative anaerobes
H. influenzae
Corynebacterium spp.
Agents in EUCAST tables
but not available in the
system
All agents for anaerobes, Corynebacterium spp., N. gonorrhoeae,
H. influenzae
Agents available but
EUCAST breakpoints not
implemented in the system
None
Compliance of manufacturers with EUCAST guidelines, 10 March 2016
MIKROLATEST (Erba Mannheim)
The accuracy of data in these tables is not verified by EUCAST and the inclusion of any materials or devices does not indicate endorsement by EUCAST
