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Complete Four-Chamber Resynchronization:
A Novel Percutaneous Epicardial Pacing Lead
Martin van Zyl, MB BChCardiology Fellow
Mayo Clinic, Rochester, MN
Twitter: @DrMvanZyl
Email: [email protected]
Acknowledgements
Principal Investigator:
• Samuel Asirvatham
Co- Principal Investigator:
• Paul Friedman
Co-Investigators:
• Vaibhav Vaidya
• Alan Sugrue
• Omar Yasin
• Adetola Ladejobi
• Ammar Killu
• Jason Tri
Prototype Design:
• Joseph Duerr
Veterinary Technicians:
• Renee Taubel
• Lisa Yngsdal
• Joanne Pederson
Disclosures: Dr. Asirvatham has received honoraria for speaking from AtriCure, Biotronik,
Boston Scientific, Medtronic, Abbott, Zoll, and Johnson & Johnson.
Clinical Problem
Transvenous approach for pacemaker implantation:
• Unfavorable or obstructed venous anatomy
• Tricuspid valve regurgitation
• Bloodstream and device infection
• Extraction complications
• Stroke/TIA
Current Climate
• Global trend towards extravascular and small footprint devices
• Biventricular pacing → well established
• Biatrial pacing → some proposed benefits
Paroxysmal Atrial Fibrillation
Interatrial conduction delay
BEFORE AFTER
Ideal Solution
• 4 chamber “physiologic” pacing
• Minimally invasive percutaneous procedure
• Avoid transvenous approach
• Minimal exogenous material implanted
Hypothesis
Pacing Device
Four-Chamber
Pacing
Percutaneous
Epicardial
Implantation
Transverse
Pericardial
Sinus
Transverse Pericardial Sinus Anatomy
Experiment Plan
• Development of novel prototype device
• 12 acute canine experiments
1 2 3 4 5 6 7 8
Advancing the Lead
Final Position with Generator
12
34
56
78
AO
PA
Electrograms
RV
RA
LA
LV
Pacing/Sensing Parameters
0
1
2
3
4
Atrial(n=17)
Ventricular(n=27)
mA
@ 0
.5 m
s
Threshold
0
2
4
6
8
P Wave(n=15)
R Wave(n=25)
mV
Amplitude
0
200
400
600
800
Overall(n=20)
Ω
Impedance
Biventricular Pacing
Biventricular pacing could be achieved in 10 (83%)
Biatrial Pacing
Biatrial pacing could be achieved in 6 (50%)
Phrenic capture
• Mitigated by repositioning the device in all 5 (42%)
animals where this was noted
Subxyphoid Access Generator Pocket
Acute Complications
No acute complications were noted
Conclusion
In acute canine experiments, a novel transverse
sinus epicardial pacing device yielded:
• Safety and feasibility
• Reasonable pacing/capture parameters
• Biventricular and biatrial capture in majority
Limitations and Unknowns
• Long-term safety and efficacy
• Effect on hemodynamics, synchrony
• Chronic pericardial reaction
• Extraction feasibility
LAARAA
PA
AO
RVLV
Anterior
Posterior
LR
1*2*
34 5 6
78*
Questions? vanZyl.Martin
@Mayo.edu