Compilation of transcription regulating proteins

Volume 16 Number 5 1988 Nucleic Acids Research

Compilation of transcription regulating proteins

Edgar Wingender

Gesellschaft fur Biotechnologische Forschung mbH, Mascheroder Weg 1, D-3300 Braunschweig, FRG

Received November 28, 1987; Revised and Accepted January 28, 1988

Introduction

As gene regulation is one of the central topics of molecular biology efforts

have been made to define the regulating elements. On DNA level, cis-acting

sequences have successfully been defined for a large number of genes. Promo-

ter, enhancer, and regulating Cor responsive) elements have been determined

which govern constitutive gene expression on a basal and often low level,

which enhance or repress transcription of the respective gene in a cell- or

stage-specific manner or which make the gene responsive to external trigger

signals, e.g. to hormones or metal ions.

In the last years, it became evident that these sequences exert their influ-

ences by interaction with specific proteins, e.g. general or specific tran-

scription factors or steroid hormone receptors. Accordingly, the number of

reports increased dramatically showing the occupation of "regulating" DNA

sequences by these trans-acting factors.

The aim of the following compilation is (i) to give an survey of the genes

for which regulatory and protein-interacting elements arc known and to

localize these regions (Tab. 1); Cii) to assign to these elements the fac-

tors by which they are recognized (Tab. 1); (iii) to list the regulating

factors, their target genes, some of their molecular properties and corre-

sponding proteins of (presumably) similar function (Tab. 2); (iv) to compare

the DNA-binding domains of those regulating proteins, which hypothetically

possess a finger structure (Tab. 3).

This listing might provide a basis to systematize the puzzle of transcrip-

tion factors, particularly those for the genes which are transcribed by

eukaryotic RNA polymerase II. Accordingly, only genes transcribed by this

enzyme are included in Table 1. Depending on which term is more commonly

used, either the genes or the gene products are listed in alphabetical

order.

The species from which the respective gene is derived is given in the second

column of Tab. 1 as is the source of the recognizing factor. The abbrevia-

tions for the cell lines are explained at the bottom of Tab. 1.

If not stated otherwise, the numbering system refers to the transcription

initiation site. Exceptions are most of the viral systems, where genome

coordinates are given, or some other examples displaying the locations with

respect to the translation start site (quoted "1: ATG"). In cases where

© IR L Press Limited, Oxford, England. 1879

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Nucleic Acids Research

several approaches have been applied to localize the protein binding site,

DNase I footprinting data were generally depicted with highest priority due

to the widespread use of this method. Sometimes, footprint windows are seen

at the non coding Cnc) or the coding (c) strand only, as is appropriately

indicated. Slight differences between the boundaries on either strand,

however, are neglected, the more extended frame being quoted. If the region

for which protein binding has been proved is located in a previously well-

defined regulatory SNA sequence, the corresponding term is included as well.

The most frequently used methods are abbreviated as listed below, they have

been applied in vitro unless stated otherwise. Data obtained by competition

experiments are included only in cases where they apparently provide val-

uable additional information on a factor already defined otherwise. Occa-

sionally, very similar data of several papers have been combined for the

sake of clearness. In these cases, slight differences might have been neg-

lected.

The sequence motifs which seem to be recognized by the respective factor are

either displayed as suggested by the authors. Alternatively, short sequences

are given as a whole. Capital or small letters reflect the importance of the

individual residues, e.g. by matching a consensus or a palindromic sequence.

The factor terminology is the same as that of the authors cited.

Table 1 displays a compilation mainly of the factors which Are defined in

Tab. 1. It summarizes the genes which are recognized by a given factor. As

far as data on the molecular weight are available they are included. In some

cases, isolation and sequencing of the cDNA yielded information on the

DNA-binding domain. If "finger" motifs were detected, their number is given

together with the type of finger structure, i.e. CH for one pair each of

cysteine and histidine residues or CC for two cysteine doublets. If defi-

nitely no finger structure is present, this is indicated as is the presump-

tive existence of a helix-turn-helix motif (ottex). The column "synonyms,

equivalents" tries to indicate obviously identical factors (e.g. MLTF/UEF/

USF) or possibly equivalent proteins from different species (e.g. B factor

(Drosophila)/TFIID (HeLa)). However, these assignments are of very different

degree of certainty and should only be taken as hints.

Finally, Table 3 is a collection of finger sequences of known transcription

factors or putative regulatory proteins/gene products. As was the hypotheti-

cal finger structure was first discovered in the Xenopus laevis transcrip-

tion factor (TF) IIIA this protein is included in this table as well al-

though it acts on a gene transcribed by RNA polymerase III.

Table 1 : Transcript ion regulat ing s i t e s which are bound by proteins

otnt product

a-actin

fi-actir.

iclin SC

SDccits/tissut"'

chicktn/rat lyocytK/rat aon-iyocytii

rat/ma

Srosophili

orottin interacting reaion'*'

-B3 to -73

-3B to 434

•itnod"'

3, 4b3, 4b

3 (coaptt.with c-loi)

l i

steutnet totif

f u l l , dyad lyitttry

TtTUAA

fictor bourn)

•yoc.-sptc.f.diltinct futoi

ssr i.

B factor

r.f.

11

2

3

1880



ictin(cytoskilitll)

Ad2nlP(Idinovirui 2•Ijor l i t * prot.)

Adh (ilcoholdihydroginisi)-distil prot.-proxii.proi.

Adhl (ilcoholdihydrogtnist)

•DH2 (ilcoholdthydrogtnls*)

ilbuiin

A-nuLV (iiphotrop•urifli Uuk t i i ivirus)

iP2(idipocyt* P2)

BPV(bovtn* pipi l -l o u virus-))

«2(I) lOlllj.n

colligtnilt

CYC1

CYC7

dihydrofolit*riductist

Eli

E2-»irly proiotir(EIIiEl)

Unopus lltvis/Hill

idcnovirus/Htll

Drosophili

•l ite

yiist

rit / l ivir

in, PCC4

•ousi/idipocytis

/r.t/HiU

•OUI./3I3

huiin/HiLl,HipS2

ymt

ymt

buiin/HiLi

I O U I I / N I U

Idinovirus 2/HtLi

Idtnovirus 5/HiLi

Idinoviidinoviidinoviidinoviidinoviidinoviidinoviidtnoviidinoviidinovi

us 2/HiLius 2/HiUus 2/Hilius 5/H.Lius 2/Hilius SffliUus S/HiLius 2/H>lius 5/H.Lius 3/HiU

-94 to -75 (SUE)

-68 to -49-83 to -52-50 to -10-40 to OS-34 to -22

- 85 to - 47-269 to -229-151 to -105- 98 to - 77

-190 to -186-145 to -138 ( l l t i r ind.)-120 to -117 (after ind,)-108 to -100

-257 to -216

-156 to -141-126 to -107-105 to - 99- 72 to - 35

-87 to -59

-124 to -108

7613 to 7639 (inhincir)7637 to 7667 Unhinltr)

- 95 to - 70-315 to -295

-79 to -60

-293 to -278 (HAS 1, A)-269 to -247 (MS 1, B)-268 to -256 (MS 1, B)-267 to -251 (IMS 1, B)-251 to -245 (DAS 1, B)-249 to -243 (HAS 1, B)

-251 to -229-20! to -165

•bout -760 to -670• -340 to -270• -270 to -170

4 binding sitisbitvun -250 ind «1

148 to 163 <-350/-33S;tnh.)225 to 238 (-273/-260;inh.)

-291 to -279 (inhincir)-228 to -214 Unhlncir)

-142 to -129 ( l l iunt 0-127 to -112 ( l l iunt C)-105 to - 89- 92 to - 66- 82 to - 64 ( t lmnt B)- 74 to - 33- 71 to - 53- 59 to - 36 ( l i m i t A)- 49 to - 53- 48 to - 33

l l , 4l, 4b

l l , 3, 4i, 4blbl ll llb

l iUl iU

4i (in vivo)4i (in vivo)4i (in vivo)4i (in vivo)

dilltions

l ll ll ll l

l l , 3

l i , 3

l ll i

2ll l , 2i, 3, 4b

l l , lb

l l , 3, 4bl l , 3, 4bl l , 3, 4bl i , 3l l , 3, 4bl l , 3

l i , 3, 4b3

l i , 2il l , 2il i , 2i

l l

l i , 3l i , 3l i , 3, 4bl l , 3, 4o

l i , 3, 4bl l , 3, 4bl ll l , 3, 4bl l , 3, 4bl l , 2i, 3t l , 3, 41, 4bl i , 3, 4bl l , 3, 4i3, 4b

AASATgtCCAtATttGScgATCTI

7GIAEGCCAC6TGACC6GGGCCAC6I6ACCTAIAAAATATAAAATA7AAAA

6CT6Ct6r.TSktcCGTC8iC6TC6TACTAA ( 4 i )6CA6C6CTGCCGrcGccggttgiGCA6CGASATCGC6TAAC66TA6ATAA

CCACSCCCCG6CSTESCCCACA6GC

22 bp dyid s y m t r y

GCAASSGATTTAGITATTTTT66CAA66ATATTTtGTAATT66TTAAT6ATCTACA6TTATTS6TTA

CCAAT

MCAT6ACTCASA6GAA

ATCC6TGCACCSATITSGSGctCCCCAA

CCAATTC6NMSCCAA

ATSABTCA6A

CCS*TSSCCeSG8TTTAC88AC8AT6AeSCCGGSGTTTACSCC6S66TTTAUrGACCTSACCSA

GCTAATA6CSATAATA6C6AS66

GSSSCSSASC ( 2 i ) ,GGSGCGGS6C ( 2 i )

GATSTG6TAAA6ITGTASTAAACMTTTTCSCGC66CCATTTTC6CSS8AA

GTGSSATTICCTTCICATAAI66C6CT

T66A6AT6AC6TA8TTTTSSMATSACGTASTSACeiAGTTTTCGCGt ( p i l . ltigtmCCKCttiuttAA666C8CgiuggSCSCEAAActiGCECGAAA

SRr (? )

UEF, USF, KUFUSF?IFII0in it

Adl- I

Adf- l ?

ADSl

KF-1

EPBF

c-fos ?

E2 GRF prod.AP-2

NF-1

AP-1

SAFHAP!RC2K\; RC2W2RCI; RC2

HAP1

Spl

E2FE2F

EIIlE-C«EIIiE-Ct

EI1A-EF, EPFElIiE-BE2 bind. f.E2FEIliE-AE2FEiir

4

5-10

9899

1111111!

12121212

13

14141414

15

16

1718

19, 20

19, 20

21

222222232223

2425

262626

27

29282921

31, 32

323133, 34, 35

31, 32

3634, 35

323534

1881



pint.p i n , product

- l a t t protottr

E4

EC-Il l TEFl

EF- l i i TEF2

e-fos

SAll-10

SAL2

GAL7

SAL81

i-globin

o*-globin

«°-globin

fl-globin

pVglobin

glucocorticoidric.ptor gim

grouth horiont

mtc i t i / t i i iu t " 1

adtnovirus 2/HtLaadtnovirus 2/HtLa

adtnovirus 2/HtLa

adtnovirus/HtLa

ytast

ytast

huian/ioust I3T3)/H.U/H.U/H.U/H.Li, A431

ioust/fibr.|B ctlls(3I3|UEHI 231)

V.llt

ytast

ytaft

ytast

huiin/HtLa

•oust/aouit, ratc t l l i j HtLi

chicktn/trythroc.|

oviduct

huian/HtLa

chicktn/oviduct

ra t / l iv t r

tailn/rit GC|HtLa

/HtLi/ H . l l/HtLa/rat GC/rat GC/rat l ivtr

orottin inttractina r ta ion '"

- 36 to - 19- 36 to - 4 ( t l tnn t I , )

-250 to -22B-213 to -186-155 to -128-125 to - 97- 90 to - 65- 56 to - 36

-171 to -135- 56 to - 39

-338 to -309 (1: ATG)

-442 to -405 ( l i ATS)

around -346-323 to -293-320 to -299 ISRE)- 93 to - 74- 67 to - 53-313 to -297-151 to -130-112 to - 90- B5 to - 50 ('SV40I51-63D

260 to 267 (-210 GALIO)367 to 384386 to 405 1-240 6AL10)404 to 421 1-270 GALIO)465 to 487 I-2B0 GAL1)526 to 530 (SAL1 pro..)596 to 600628 to 631671 to 679

around -4302 sttts bttvttn appr. -410and -300

around -250 and -170-292 to -270 (distal)-205 to -183 (proi.)

at about -95

-90 to -65

-102 to -74

-73 to -66-71 to -52-63 to -55-53 to -38

-98 to -80 (appr.)-89 to -71-196 to -176-162 to -129- 73 to - 65• 50 to - 42

2 s i t ts , about 1.1 tbupstrtai tht poly(A) tract

-290 to -254

-287 to -265-167 to -145-140 to -116-140 to -106- 93 to - 66about «90/t|20 ( I " intron)

• t thod" '

lala, 3, 4b

la, 3, 4bla, 3, 4bla, 3, 4bla, 3, 4bla, 3, 4bla, 3, 4b

lala

la, 3

la, 3

3, 4bla, 3la, 3, 4a, 4b3, coip.3, coap.

3, 4b3, 4b3, 4b3, 4b

la, I tI t , 4ala, I t , 4ala, I t , 4ala, I t , 4aItItItIt

lala

lalala

la

la

la, 3, 4a

la, 3la (in vivo)la, 3la, 3

lala1cla, Icla, ItIc

la

la

lalalalala4i

stoutntt •oti f

CCTTAA6AGT6TCCTTAA6AGTCAG

GGEGGSATTGG6AACCCCCCATTGSTGACgcAC6G6C66S'ATT6STSSSC8TEST

ACSTaACGT{ 8TGACGACGTtACGt

AACACCCAAECA

ACCCACACATTT

CASTTCCCGTCAATCGATGTCCatattaSSACATCGATGTCCatattaGGACATCGCGCCACC I 2 i )6T6AC8TEATGTCCatATtaSSACATCAAECCTGESECGTAEAGAGSECCTTGSSSCGCTTACCAGTTCCGCCCA

AcTTATATCG8ATTAGAAGCCGCCGC6SST6ACA6CCCTCC6AASSAAGACJCTCCTCC6C6C8CC6CACT6CTCC6AACAAT3' -CTcCT-5 '3 ' -CTaTT-5 'S'-CCCC-S1

3'-CTaTATATT-5'

23 bp dyad s y u t t r y

23 bp dyad s y u t t r yGSCTCAACAETECTCCGAAGTATGSCTCAACAGTiSTCCGAGCGCT

CGGcgcActcTcgcCCG

AGCCAAT

CCAAT

CCGTECGG

AASATAAGGCESEECGSGTGTACAS

CCACACCCGAGCCAATGGGGCGSGGSaTCtEGGCAcctTECCCtSAgCCCCAATSASSAGSGG

3 i GR constnsus

TGSCCtgcGSCCAg....<SSgCACccac6TSaCC

. . . T A A A I . . .

. . . T A A A T . . .

. . . T A A A T . . .GgcACAAtgT6TCCT

f a c t o r bound

6 . | CRT6.CRFUSF I IS p l ! CRFSpl

E4F1E4F1

ECl l - ind. f.f-EBPERF

'factor 1"•factor 21

•factor 2""factor 3"

(8AL4-dtp.)6AL4SAL46AL4GAL4GAL4GAL4SAL4lSAL4-dtp.)

SAL4

6AL48AL4GAL4

GAL4

CTF/NM'

CCAAT boibind. prot .

CTF/NF-I

GR

i

AP-2AP-2GHF-1snr-i»;GHT-IGR

UL

3132

373737373737

3838

39

39

40412,

434344444444

45,47,45,•5,•5,46464646

4545

454949

45

50

51

52525252

5050

53S353S3

54

55. 18

IB55555556

42

464B47, 4947, 4S47, 49

1882



HJV inhanctr(hipatitiiB virul)

HIS3

H1S4

hii tont H2B

hi i tom H2S-1

hi i toni K3

hi i tom H4pHu4A gint

FOI08 j t n t

HIV-I

MS-CoArcductast

Nflt

m

hsp 70( h u t shockprottin)

raWECj6H,!H4T8;rat-2

/livtr

m c.iu/SCiGH,

/Al(i.,HtpS2,H22/A]t>.,HtpS2,Hip3B/Aln.,HipE2,K22/Aln.,HipE2,H22,H.p3B,SK-H.pl,Hili

y(ast

ytait

huaan/HtLa

I H urthin/blastula,gastrula,ttstis/tiitii/bla,ga./bl.,ga.,ti:tii/bl.,ga.,ttstii

Droiophila

huian/HiLa

•

Drosophila

/Hut-78, HiLa

haiitir/livir

yaait

y»ast

Drosophila/K,i ymtIt./SL2it.

fK,| ytaitIt.It.It.it./SL2It,

auian/HaLa

-236 to -146

-187 to -173-142 to -106- 95 to - 69

8S1 to 900 (UE3)972 to 391 (UI2)

1029 to 104S (UE1)1181 to 1204 (E)

-337 to -323 ( l i ATE)-287 to -272-254 to -231-209 to -194 •-126 to -108-102 to - 92 ( I r i n i c r . - I n . )-259 to -232 ( 1 : ATE)-217 to -194-203 to -190-I7B to -165-151 to -136

-53 to -40

-170 to -163

-106 to - 89-103 to - 76- 50 to - 43- 31 to - 23

-43 to »30

-110 to - 80- 63 to - 35-123 to - 85-120 to -115- 69 to - 19

-40 to »30

-83 to -43 (LIR1

-247 to -223-201 to -136-142 to -103- 98 to - B2- 62 to - 44- 42 to - 13

82 to 102 I l i l u c t r l

256 to 281 ( l i l i n t t r )312 to 333

-258 to -229-189 to -165-108 to - 40- 99 to - 38

- M to - 37- 92 to - 66- 85 to - 72- H to - 37- 62 to - 49- 40 to - 12- 37 to * 30

-166 to -137-147 to -144-158 to -131

around -149-112 to - B4

3

4blala, 3

lalalala

lalalalalala , 3lalalalala

la , 3

la, 3, 4b

la, 3, 4bla, 3, 4bla, 3, 4bla, 3, 4b

la

la, 3la, 3la , 4a ( in vivo)la, 3la, 4a (in vivo)

la

la, 4a

lalalalalala

la, 3

la, 3la, 3

lala2a (in vivo)la

lala, 3la , 4a, 4b, 4dla, 3la , 4a, 4b, 4d2a (in vivo)la

la4bla3la, 3, 4b

ASSTAASatcAEGESACS

CUT

6SSTTATSTCATTE6AT6TTCCTATT6l.TTSSMMTl.TSITIACACUTSTE8TTATCCT6TTT6CT

T8ACGA6A6TCA2 l i t i i : TASTCA|AASTCATTACTCTSACTCTSACTCTSACTC (2 i>

TSACTCCABTCATSACTA

ATTT6CAT

ATTT6CAT

ATTSS•

ATTTECATTATA

TATAA8TA

SATTTC66TCC ?SAUTSac6AUTS| CUTASAAATSCAAT| 6STCC; TATAT

TATA

6AS6C6T666 I - 7 7 / - 6 8 )TSS6C6SSAC ( - 6 6 / - 5 7 I6B6SAST6SC ( -S5 / -46 )

CCSCCC; EESCE6CETSAC

TTATT

ATSSSTTTTTETAAATATAAAACAUAACCCAT

aaataaaEAAtaTTCtaSaatcccCgaSAAatTTCtctggicgtCTgcSUtgTTCgcSCtcSttgcTTCgaSA;

CtcGaaTgTTCgcSAaaA1 '

CtcSTTgcTTCgaSCtcETTgcTTCgaSCtcGUtgTICgcGCtcSAAtgTTCgcSTATUATASASSCSCTATAUTA

ATTSEATTESCCUTCCAAICtgEUtaTICtcS

T3 r . c . ?

T3 riciptorEC2

EF-C?

GCM4••1

•1

GCH4?ECM4

'1

OBF

DBFCDFOBF

8 (actor

H4TF-1H4TF-2

HiNF-A

8 (actor

SplSptSpl

HLTF/UEF/U5F ?

SBF-E

S8F-BSBF-E

HSIFHSTFHAPHSTF

HSTFHSTFKSTFHSTFHSTFTABB (actor

CTFCTFCTFCCUT-bind. ( .htit-ind.l.

57

585957

60606060

6161616161626161616161

63

64

64646464

3

6565666766

3

686869

696969696969

70

7070

71, 72717374

72717571757374

7676777878

1883Downloaded from https://academic.oup.com/nar/article-abstract/16/5/1879/2377768by gueston 18 February 2018


gent.gene product

hsp83 (hspB2)(hut shockprotein)

HTLV-I(hum I -c i l llyiphotropicvirui)

IE 1

IE-1(iO| ICPOi VvillO)

IE-3 (IR.)<a4; ICP4| Vv.175)

IE-3 I IS.)(i4p ICP4; Vvil75)

IE-4/5Il47| ICP47| v»ll2

ILV1

11V2

iiaunoglobulinheivy chiin

species/ t issue'"

Drosophili

ye ist /ye ist | Dros.

/huiin T cells

huain CKV/HiLi

HSV-l/HtLl

H S V - I / H I L I

HSV-l/HeU

HSV-l /HiU)

ytist

ylist

•ouse/huiin BU,HeLi/J558l,B«5I47/huiin c t l l i/huiin B ctl ls/hunn,ioust B-

orottin inttnctino region'"

-110 to - 7B

- 76 to - 52- 74 to - 49 (SRE)- 69 to - 32 (SRE)- 67 to - 62- 47 to - 42- 40 to - 29- 36 to - 22

- 86 to - 50- 39 to - 17

-309 to -27B-211 to -183

•181 to +334•209 to «217•228 to 4246

-772 to -759-729 to -716-682 to -669-628 to -614-498 to -473 (enhmctr)-473 to -439-447 to -424-41B to -399-376 to -353-335 to -314-304 to -281-267 to -227-215 to -IB9•345 to 4359 Hit intron)

-71 to -46

-155 to -135

-252 to -235-224 to -204-193 to -178-13B to -120- 90 to - 71

-377 to -356-230 to ?? t o - 35

-12B to -120 I I I ATG)- 51 to - 42- IB to - 9

-359 to -343 111 AIB)

-154 to t54 (V. proa, oct.)-123 to • 1 IV. proa. Oct.)- 56 to -SO (V. proi. oct.)- 56 to -50 (V. proi. oct.)- 73 to -44 IV. proi. oct.)

ind non-B-ctlls

•oust/tutor/huun, aouie,lonkty ctl ls

/ • y t lou/BJA-B.MU-4,HeLi

/ •y t lou/HeU/BJA-8

/huiin, louse,loakey cells

7 sitts (IgHtnh.)34S to 360 lenh. ;E1 sitt )

352 to 359379 to 437

378 to 391390 to 412392 to 438 I d ,

419 to 466 (nc)399 to 411 (int. pE3 site)

aethod'"

l i

2i

3, 4b3, 4b3, 4b2i

2a2a

l il i

3l i , 4il l , 4i

l ll il il il il il il llal il ll il ll l

2i, 3

3

l ll il il il l

l il il l

l il il i

l i

334b4b3

2i3, 4b

4i (in vivo)l i , 4a

4a (in vivoll i , 4il i , 4a

3, 4b

seouenct l o t i t

SACCTTATAASGSCiSACCGTCESAGIAG

GAIIGSATT6G; AGAAGSGAAAA6AAGGSAAAA6ATI66GGCGSG

TATAAA

GAAGcCTCTAGAAgtlTCTAGAGiCTtCTATAAAAGCtSACGC

ACCCTGCTTGCSTCITTSTTIC6TTTTC

TGGCACATSSCCAATTSGCCATTAGCCATTGGCTAITG6CCATTGGCTCATGTCCAA

CI I ICC ?TT66CA6IACATC

C I I I C C ?iIIG£CA6IACAICTTS6CA6TACATCTISGCIAIAIGCCAA

GGGGAAICGICACTGCCGCCCCTIIS

CCGCCCGGGC66CCCGCCCCGCCCCCSCCC

CCCGCCGG6CGE | CCGCCC) CCSCCCCCGCCC ( 3 i )

SASICAIGAGIGAASTCA

TSATIC

AIITSCAI (-57/-50)AIII6CAI (-57/-50)ATTISCATAITTGCATATTTSCAI

ASTCAAGtTGSCCSATC

AASAT6SCincl.TGISGAAA;CAG6I66C

CASCTSSC

6TCAIGTG8CAAS

l i c t o r bound

HSIF

C l f >,CBP ?

cir

CIFSpl

IFII1 ?,TIF ?

HAPIAB

HsirHSIF

for! I , fora I I

•

NF-1NF-IKF-1NF-I

KF-1

s4 protein

|4 protein

SplSplSplSplSpl

SplSplSpl

GCK4•

•

6CH4

(Ig)KF-A

KF-AINF-A2

rA prote insNF-pEI

IgPE-1

«T-iE3jGMItt

rtf,

77

7977797676

7679

73, 8073, 80

7272

818181

8282928283B383838383B3B3B382

B4

84

8585858585

858585

616161

61

8687888889

9091, 92

9394

939595

91, 96

1884



/ayelota/HiU/huaan BH,H>U/HtLi/BJA-B,»0LT-4,HeLa

/KM-4,HeLa/BJA-B/«0LT-4,HeLa/ayeloia/nHLT-4,Hela/HeLa/BJA-S/BJA-B.IIOLT-4,H»La

/HtLa

lonkey e d i t/BJA-B, Hela

huiin/ioutt NSI

iaaunoglobulin aouie/huaan B-cells.: light chain /hman EV,HiLa

/huaan calls/huaan B cells

huaan/BHH-23

insulin rat/haaster HIT 112.2/HIT 112.2, BHK/HIT H2.2,BHK,H(La

0-interferon huian/H663

lectin soybean

LPV LPV/huian cells(lyaphotropicpapova viruil

lysoiyae chicktn/rl/CO/rl/ru/r l/ r l ; ru

HEL1 yiait

aitallothioniin 1 aousi/L (Cd-ind.)

rat /rao.CdR/Fao.CdRtCdCU/Fao.CdRtCdCI,/Fao,CdR«CdCU/rao.cdutcdci./Fao.CdR

/Fao,CdR»CdCl.

• i ta l lothiont in huaan/rl

MA /U<La

/Hila

/HtLa

/Hila

/Hi la

/HeLa

/HtLa

399 to 413

439 to 4E1

456 to 626

477 to 486

497 to 517

497 to Sis

497 to SIB

519 to 529

S23 to S3S

531 to 563

532 to S53

S32 to 564

534 to 566

around t541

573 to 576

119 to 139

214 to 244

500 to 520

9 site in K enhancer

-72 to -S2 CVL prot.)

enhancer

-332 to -295 (enhancer)

-222 to -205

-169 to -154

-167 to - 94 (uninduced)

- 68 to - 38 I • )

- 77 to - 64 (inducedl

-202 to -135 (uninduced)

-194 to -173

-165 to -126

enhancer

-202 to -171

-202 to -160

-200 to -174

-200 to -1(0

- 80 to - 49

- 80 to - 54

30 bp at about -230

-153 to -127 (KcE.,HRE,>

-146 to -141 (USE.)

-191 to -195 (EC boi)

-176 to -168 (IKE.)

-153 to -143 (IKE.; GC bo<)

-126 (HRE.)

-107 to - 97 (PIKE.)

- 63 (HBE.I

- S3 to - 46 (UK. )

-266 to -242 (ERE)

-230 to -1ES (distal BLE)

-224 to -203 (distal BLE)

around -190 (distal BLE)

-190 to -167 (distal BLE)

-130 to -110 (proi. ELE)

-110 to - SO (proi. BLE)

- 72 to - 57 (proaotar)

4a (in vivo)

la, 4a

3la , 4a

la, 4a

la, 3, 4a

la, 4a

la, 3

4a (in vivo)

la, 3

la, 4a

la, 4a

la, 4a

3, coip. uith

H2B proa.

3 4b

la, 4a

la, 3

la, 3

la, 3

3la, 3

3, 4b

3, 4b

2b

lalala

la (genoaic)

la (genoaic)

la (ganoaic)

3

la , 3

la, 3

coap.: IgH

la, 4a

la, 4a

2a2ala , 4a

2a

la

2a, 3

la

4a4a4a4a4a4a4a

la , 4a

lalalalalalala

CM6TGEC

ITECMAT (541/549)

ETGTTTT6CTCA•CUCCT6•TSCAMTASATTTSCATATTT6UT

ATTTECAI (541/S4S)

ATTT6CAT

TTTTASSAAGCAAAAACAATTT6cgT (oc taaer )ATGAAAAT

GESSACTTTCCUTTTSCATATTTECATATTTSCAT

TTTCCA|SCC«CCTS

ETEEAAATTMTAATCTAATTCCCTTTCTGCASACTTAEC

SAATTTAATTAAATTAAATTTTAAATT

CCUCAAACCSAAAETCCK6

ATTCCTCTSTATTCCTCTET

AUAEAESAAT

TTCSEccatatgtcttCCGAA

TSCAC|CCGCCCE|TECECGCACTC

66S66C68TSCACACCSTSCACTCC8CCCTGCECTCGSTSCGCTCGTCT8A6TSCAT6C6CCCG6

TBTCCT

CC6CCC6CGG

GC-feoi e leacnt

IgkT-A

luPE-2

lgPE-3

(Ij)NF-A

K T - * 8

(IglKF-ANF-A1

HF-A2

R2RlITF

EOX protein1

lgPE-2

ERPRERPRSRER, PR

EAL4

Spl(?)t?

Spl ?

Spt ?

ERAP-2

AP-2

AP-2

AP-2

AP-1

Spl

9395869594

95, 97

9597939795, 98

95, 93

94

63

91

95

999999

9163, 96

B998

100

101101101

102102102103

104104

94

105105106106105106

45

107107

108108108108108108108

109no

181111818, 110

110, 111

110, 111

1885Downloaded from https://academic.oup.com/nar/article-abstract/16/5/1879/2377768by gueston 18 February 2018


pint product

KFil

HHC d i i i IH-2K"

KHC d m I IE:

BHC d m 11HLA-D1S

02-iicroglobulin

MTV(lousi ianarytuior virus)

Ho-MV(Noloniy lurintItuktaia virus)

C-IOI

nsv

t-lie

ovilbuiin

PGK(phosphoglyciritttimsi)

polyoil virui

iptciM/t i i iui ' "

ycitt

y m t

•OUI./3I6/H.U/EU3I47

/3T3;KELiH.H

•ouit/B lyiphoai012)

huun/B c i l l i

•OUH/BUGI47

WlTV/iouse (NIH3I3)

in•••• |ru• •

• •

•

•

•

•

/co ort o u » l iver

/ r l•

/MEHI231,EL4,3T3,L,ttl,F9,PCC4

/UEHI231,EL4,3T3,l/UEH123I,EL4,3T3,L,KEL,F9,PCC4

/HEH1231,EL4,3T3,l,PCC4

/«EHI231,E14,3T3,L ,BEL,F9,PCC4

/UEKI231,EL4,3T3,L

nt/ ioui i LTK'

tarcooa virui/huaaninin

huunfKtLi

chickM/HtLi

yi l l t

/IOUII 3IE

/F9+RA

orot l in i n t i nc t i na r ta ion ' * '

-4B2 to -4S8 IP b o i l l l ! ATE!-36B to -319 IP*t)-318 to -287 <Pt»)

-310 to -289

(-199/1-175 to -158-197 to -158-175 to -152-172 to -160-171 to -161

(round -86-65 to -49

•round -600

-136 to -114

-83 to -55-82 to t l 2

•305 to -289-283 to -269-216 to - 79-192 to -163-190 to -163

to -10!to - 86to - 71

-189 to -166-159 to -135-127 to - 84-124 to - 71- BO to - 58

•113 to <143•242 to *27I•1145 to *1167+1172 to +1193

7932/7937 ind 8007/6012

7939/7951 ir.d 8014/B0267954/7960 n d 8029/8035

7963/7970 ind 803B/B045

7977/7981 ind 80S0/B056

79S4/7996 ind 80S9/B07!7997/B006 u d B072/80B1

169 to 176ISO to 1B6190 to 196inbincir-9B to -71 (LIR)207 to 233

600 to 622644 to 666

-90 to -66

-523 to -496 (HAS) ( h ATS)

5109 to 5123 (A inh . , • )SHE to 51315120 to S12B

• i t h o d " '

l llal i

l i

l il il l , 3Ib, 4b3, 4b

3la, 3, 4b

3, 4b

l i , 3

2a (in vi t ro)2l l in vivo)

l ll l4 i , 4bt i2l2i2i2ll il il llala

l llalala

3, 4i

3, 4i3, 4i

3, 4l

3, 4i

3, 4l3, 4i

l l , 3l l , 3l l , 3coti.:!gHl il l , 41

l ll l

t l , 2 l , 3, 4b, 4d

l l , 3

l l , 3l i , 3la, 3

Ifoutnc* toti l

TTTCCSATTAGSAATTTTCCTAATTASTCCT'TCAATASAACCTTCCtAATIAEStCA' TCAACSACAS

TTTCITCATTSSUCA'TCAATECCAB

668AIICCCCA!TSSeSA;TESSSAtTCCCCAESS6ATTCCCCATESBATICtXCAITSSSEAtTCCCCA

CCTASCAACAEATEATTEE

ATTTETAT

SESEATTCCCCAT

ASAACATTETTCT M i lIEIICIIEITCITGTTCTrenciT6TTCTACTSTTCt

AET6TTCTIETTCT ( 3 . )TTSSAATCTATCCAA

AEATCASTAEATCASA

SAACA8

TSAATATBEECCACASSAIA

T8TBBTAT

caseCESCTCASSSCCAASAACASATE

TSETTTSCAACCAC

smiuCCAATACASSATATCISISETAASCAeil

ETCAAAgSTCAAA

TSACIAAcTEAACTAACTSACCECAEtTESCCACTSACCSt

f a c t o r bound

PStfPRTr+IIATilPBir+MIi l

PRirtlUTal

AP-2KEF1

H . L J B l i c t o r

I-boi bind.prot.

KBF1

• u r i m Hr-1• u r i m NF-1

+ F-iSBSRSRGRSR, PRSR, PRSR, PRGR, PR6RSRSRSRTGECA-bind.pr.• NF-1

SRSRGRSR

LVi

KT-1 ?IVb

?

IVc

KF-l ?GR?

I jPE- lCBPEBP20

AP-2AP-2

COUP

PEA1PEA2PE*2

112112112

112

11318

114113115

116116, 117

118

114

3030

119119120121106106106106119119119121122

119119119119

123

123123

123

123

123123

12412412494

125126

IB18

127-130

131

132, 133132133

1886



protect in

qa-2-qa-.

qa-2

qa-4

qi-3

o.a-y

qi-lS

q«-lf-qj-IS

ml(c-Ha-rail)

rb<S-3A

<ribulo««-l,5-

biphosphitt

carboiylait)

ribofoul

protain L23

• " rp2B

1 • BP5IA

• • S331 • S24-L46

RSV(Roui sarcoia

viral

loaatostatin

SIM

surfic* antigtn

(S lint)

SV40

/3T6

/3T6

/3I3, F9, Ltk-

/3I6, F9

mi, n/3T6, CV-1

in/Hill

/F9, (., HaLa

/3TS, CV-1

/3I6, CV-1

/3T6, CV-1

/3I6, CV-1

/3T6, CV-1

rat/rat 6H,

/EH,

/SHs or H.Li

/GH./EH,

Nturospora crassa

•

•

1

1

1

•

•

•

•

•

1

huian/Htla

P"

yeast

yaait

ytist

ytist

ytist

/quail OT-6

rat/PC12

yiast

HIV/HlLa| UISH

/CV-1

/Kill

/Htla

/HlLa

/HtLa

/H.LJ

/Htla

5140 to 5164 (E ink., r)

516S to 5198 (! Mb., B)

5170 to 5192

517B to 5220

5181 to 5200

5207 to 5239

5212 to 5234 <«ib.)

5223 to 5246

5155 to 5174 (C .nhmcfl

5299 to S29I (ori)5293 to 10 (ori)

25 to 75 (ori)

73 to 120 (EP)

118 to 162 (EP)

-210 to -190

-175 to -145

-130 to -120

- 73 to - 28

- 65 to - 36

around -510/-512

-391

• -1271 -510

• -374

-449

• -2641 - 70

• -6B11 -5121 -412

• t236

• -144/-226

262 to 271

289 to 298

340 It 349

400 to 409

509 to 518

520 to 529

-257 to -245

-227 to -210

-153 to -139

-125 to -109

-425 to -382 (It DIG)

-288 to -269

-252 to -233

-358 to -319

(-460/1-440 to -404 <liAT6>

-170 to -148 (li ATS)

-416 to -402

-380 to -356

-229 to -203 (/-192)

(-155/1-146 to -121

-55 to -32

-344 to -312 (P*» bo»>(liATS>

3004 to 3025

(about -190 to lha proiottr)

5172 to 5212 (ori)

5211 to S235 (ori)

35 to 129 (ori)

34 to 108

47 to 109

(40/154 to 10! daily proi.)

53 to 57

63 to 70

84 to 91

la, 3, 4a, 4b

la, 3

2a, 3

2alalala, 4a

3, cot?.

la

lalalalala

lalala2a1

1111111111111

i, 3

>, 3

>, 3

>, 3

•, 3

lalalalalala

la, 3

la, 3, 4b

la, 3, 4b

la, 3

la, 3

la, 3

la, 3

la, 3

la, 2b, 3

la, 3

la, 3

la, 3

la, 3

la, 3

la

la, 3

la

la, 4a

la, 4a

la, 4a

3lala, 4a

4b4b4b

6ACATCCTCTTTTA*TTA6TT6KT6eiXTCca6i.SG6ti.6I

ASA6S

UTECCCTCcaSASSSUET

ASTTSCTagSCAACT

AST6T6STTTTGCAASA66AA6C

ASTTSCtagGCAACT

66S6C| 6CCCC

SAS6C <3i>

6»B6Ci E6E6C

6CCCC|6CCTC (3>)

CCTSAAAAtgiataagaaa

GATSTTTAAAATTGAtTATATATATAtTCATSAtTATATATATAtTCA6SATGASTTTTTAl.CC6SATAAATCCTAACCC6SSTAATCECTTATCCEECTAAETGTTTAACAC6TTAAT6CTTTATTCSSETAASTATTTAAECEGCAAAACSCTCATCCESE6AATAACTTATASESETAATSSCTTTTCCESTTATACATTCATCCEGCTCAACACTCATCAGSATSASTGATTCTCCGSATAAACAATTATCC

6CTCC6CCTC

GCCCC6CCC6

6SG6CGGGGC

666S6CS86C

CCCCC6CCCC

6CCCC6CCCC

6ATTTACACT

6T6ASSTAATAT

ETSTSSTTAATATATCAITTTCACT

cooiantun

AACATCCETECATACCTCCBTACAACACCCATACAI

TAT6CA

AA6CAccgT6CATGC; 6T6SAAS

TEAC6TCA

mCCTAATTAST6TC'ACAATGACAS

acTSECtagtaSCCAAC

TAE8C| EA66C <2i)

SAESC Oil

E8S6C (3i); I6S6C (3i>

66SCSS <5i>

4-6 binding nt.i

(Spl coniansui)

PEil

f

T-AgEBP2061-llc

EF-C

T-A,

T-Ag

T-Ag

T-Ag

T-Ag

PUF-Iqa-IF

qa-lF

qa-IF

qa-IF

q

q0,qQ.qq

-IF-IF-IF-IF-IF-IF-IF

qa-IF

qa-IF

SplSplSplSplSplSpl

ST-1

6T-1

6T-I

ST-1

TUFTUFTUFTUFTUFTUF t ? (?)

TUFTUF

EFIIEF1

CREB

PRTFtMIal

KF-

T-AgT-AgT-A,ISF («pl)

spiSpl

SplSplSpl

134, 135134135137137138126

to

139

138138138, 140138, 140138, 140

141141141142141, 143

144144144

144144144144144144144144144144

145145145145145145

146146146146

14714714739, 147148

147147147

149

149

150

112

151

1521S2152IS3154155, 156

156156156

1887



HIM. laii i it /t i l im'"otm product

/H.Li/H.Li/•onliy cilli

/HiLi,HipG2/H.U/H i l l

/H.U/H.Li

/H.Li/H.Ll/H.Li/H.Li,H.pS2

/H.ll,H.pS2/H.Li

/H.Li/BJA-B/Hi l l/BJA-I, tlOLT-4/BJA-I, HOLT-4

95 to 100S3 to 97 (iirly proi.)(12/152 to 103

112 to 120 (P aotil)114 to 126tnhancir

US to 149 ( S p H , - I I lot I I I )125 to 145

149 to 176154 to 164165 to 178 (6T-I •o t i f )168 to 174

184 to 192 (Piot i f )187 to 201

197 to 221 (Sph-l,-II aotifi)200 to 216204 to 214 (Sph, octaiir)204 to 214 (Sph, octaiir)204 to 214 (Sph, octaair)

/BJA-S, IU1LT-4, H.Ll 204 to 214 (Sph, octu i r l

/H.Li/H.Ll/H.U/H i l l/H.Ll/H.Ll, BJA-B

/BJA-B/ r l/H i l l/Hlla,HipG2/Hi l l

/H i l l/H i l l/BJA-B/HtLi,BJA-g,IU)lT-4/Hili,SJA-B,n0lT-4/HiLi,BJA-S,K0lT-4

t t HSV-l/Hila(th)iidimHim)

/rit livir/•ouil 1112

tryptophan rat/livirorygtnast

tyroiini aiioo- rat/livirtrantfirast

UIB iiENA I . lmi l /h ia inIHXT-4

U2 v.m huain/Hila

/H.li.Hinl.i,BJA-B, 293

I . Imii/haianira.I-4

US ul»A I . l i .v i i /hui inIUXT-4

utiroglobin rabbit/ru

221 to 248224 to 240 (TC-1, TC-II)225 to 248226 to 23G229 to 233233 to 237 (IC-lIi L itrand

only)

234 to 257236 to 255236 to 251 (6T-! lo t i f )240 to 246241 to 257 (61-11

257 to 277 (81-11 io t i f )263 to 272 (6T-II)262 to 292 (ET-II)268 to 275 (ST-I1126S to 275 (61-11)272 to 293 (61-11)

-113 to -91- 90 to -68- 62 to -42- 95 to -67- 96 to -74

at about -1200-440 to -387

-2511 to -2490-2454 to -2423

-242 to -217 (nhinctr)

iround -221 (proa.)

-275 to -203-270 to -259-248 to -238-231 to -222-221 to -214

-297 to -256-256 to -252

-232 to -211-204 to -192

-2709 to -2690

•1

4b

la,la

lalala

l l ,la

la,lala,lb

l l ,l l

l i ,l i3,l ll ll l

l ll ll ll lt ll l

lalalalbla

l i

3,l i3,3,3,

lalalala3

l i .la,

la,la,

l i

3,

l l4|4l4l4l

l l ,la,

lala

l l ,

ihod'"

lb, 3Inuclii)

lb, 4a3

4a3

3

4l

lb, 4a3, 4i

3, 4a4a

4b3, 4b3, 4b3

3

lb

4a

4a4a4t

4a4b4a

4b4b4b

4a4a

lblb

coip. withH2B proi.

33

3

SMUtnc* lot i f

G6ECGS (3-4>)

TTA8TCA6

T6CATGCTTT6CATACTT

I6CTTTGCAT

ACTTTCCACACC

TEGAAAS

ITA8TCAS

TGACTAATTGA

T6TTT6CAT

TGCAT6CTTTGCATACTT

CTTTGCAT ( 2 . 1••

CTGSGGAgcCTGGGSA

6AGCCTG668ACTTT

GGAGCCTS6GSACTTT

CCCAG

ACTTTCCACACC

GGGACTTTCCACACCCTAAC

ACTTTCCACACC

TGSAAAG

TTTCCACACCCTAACTS

ACATTCCACAEC

ACATTCCACA6

ACATTCCACAGC

ACAGCTG

ACA6CT8

ASCTGSTTCTTTCC

ACCCCGCCCA

AGCCAAT

SGSGCGGCGC

CCAAT

CCAAT

(6RE comtniui)• •

CT6TACAggiTGTTCT

TA8AACAiicAAGTCC

ATGCAAAT8AGS8

ATGCAAAT

SGGCG8

ACSCCC

EGGCGG

ATGCAAAT

ATGCAAATA6

6TGCC

M U S C A T

G6T6C&C&CCS8T

TGTTCTCC

fac tor bound

SplSplSpl- iqu.

AP-1

AP-1

Oct. -bind. f.

AP-1

oc t . -b ind . ! .

oct-eiA

oct-BIB

oct-B2

oct-B3

AP-2

AP-2

AP-2

EBP20

AP-3

AP-3

GT-IIC

6T-IIBa

ST-IIEB

GT-MA

SplCTF/KF-1

SplCBPrlF-y

81!SR

6RGR

Spl 'Spl ?Spl ?Octl-Fictor

oct.-bind.f.

PI!

I l k

156157,159

21,97

111

98,97

9716098,21

21,97,

97,98

161161161161

97110IS

16016298

9812698,21

110

98,969B969696

16350,

16312S117

164164

165165

166

63

167167167167167

9797

1(9169

169,

158

98, 160

160

160

98, 1609B

98, 160

160, 162

160

163

170

1888



/rl

In

in

/rlIn

In/ru

/rl

InIn

vaccinia virus /virus particleextracts

vitellogenin II chicken/oviduct,liver

whey acidic rodents/rat tauaryprotein glands,(HAP) huian HCF7

-2709 to -2676

-2680 to -2660-2674 to -2652

-2643 to -2619-2643 to -2620

-2486 to -2471-2426 to -2402

-2394 to -2376

301 to 316968 to 1000

-29 to -14

-620 to -597-604 to -585

-177 to -160-129 to -126 (c only)-123 to - 94- 91 to - 99 (c only)- 86 to - 40- 33 to - 20 (c only)

la, 3, 4a

la, 3la, 3, 4a

la, 3, 4ala, 3

la, 3la, 3

la, 3

lala

la, 3

lagenoiicdeicthylation

la, 2a, 3la, 2ala, 2ala, 2al i , 2ala, 2a, 3

rent!

A8TCCTTT

mici

I8TICIT6T1CACT

T6TTC»CT

t8TTCACT

I6TCCTCTISTTCCCA; ISII .ACI

TATTACT6AATTAATA

GCGI6»CCGG»6C!GM»SA»C»C3'-TTCTT6T8TAACTAB6SCAC-5'

TTTAAAAAT66CCTCCAT

MGC8T66CCAA6AASSAAST8A!CCAAGITTTUA

6!

PR8!

6RPR

PRPR

6 8 , PR

PI!PR

Elifit

169, 171

169, 170169, 171

169, 171169, 170

169169, 170

169, 170

170170

172

173, 174174

175175

175

175

III AUUi I 1WI tu tllf tUUlT^UTll bl J f AIM*IIITV ^111 I1J1VS fcco, chicktn oviduct) r l , rat livtrj rut rabbit utirus.

• n« «ust rrrqutntiy us*o appiDainis ait anuivviaito *s IDIIUWS;1, footprint ing Wchniquts: la, DNast I; lb, Mthidiuipropyl-EDTATcUI) (HPE); 1c, DNait I I ; Id, hydroiyl radicals; I t , photofootprinting in vivo; 2,(lonucltasi digisti: 2a nonudmt I I I ; 2b lubda •lonuxliaM) 3 gtl rttardation) 4. chuicil UNA aodification: 4at itthylation prottctton; 4b,•tthylation intirftrinci) 4c, tthylation protfttion; 4d, ithylation intirftrtncij

factor

&0K p ro t i in

«4 protiin

Adl-1

ADR1

A P - 1

Table

sourct

toybian

huun(HtLi)

Drosophila

ytast

hlllln

2: TranscriDtion reaulatina

gem

lictin

90 (H5VI»4 •

<dh

UH2

colliginanIL-2 (?)•ttillothiontin II»polyou virus (?)rit itroiilyiin (?)SV40 tnhtnctr

«. W. (kBa)/finger str.

SO

2.

170

151 / 2 CH

47

factors

svnonyns.

tguivalents

ICP4,Vml75

UL.

104

84, 17684

11

13, 177

21, 110, 178

21

1889



factor

AP-2

»P-3

B factor

CBF

CBP

cor

CMAT-bindingfactor

CCAAT bo.

bind.prottin

CDP

COUP

CREB

CRF

CTF

ElA 13S pro te in

E2F(EIIF)

EIIA-F.F

ElIaE-A

EIIaE-B

ElIiE-Ca

ElIaE-CS

E2 08Fproduct

E4F1

EF1

soarct

HiLi

HlLl

Drosophila

tta urchin

lOUfthuianratrat

sta urchin

huiani n urchin•oust

u n i t , rat,huian(HiLa)

» a urchin

huian(HtLt)

rat

huian ?

huian(HtLa)

adtnovirus 2,3

HtLa•oustHtlt

HiLa

HlLl

HlLl

HlLa

HtLa

rtc

HiLa

quail

otnt

BPVGH•ttallotbiontin UAc-iycKHC class I H-2IC"SV40 tnhanctr

tnhanctr (SV40)

ictin SCbiitont H3histont H4

hittont H2B-1

i-globinhsp70 ?LTR <HSV>tk (HSV)

histont H2B-1

htp70histont H2B-1o s ( l ) collagtn

«A globin

histont H2B-1

ovalbuiin (chicktn)

ovoiucoid '

a-actin '

soiatostatin

E2a-U>(Ad2>

a-globin0-globinh«p70tk (HSV)

tarly gtnts (Ad)

E1A tnh. (Ad!)E2 (adtnovirus)E2 (Ad!)

EIIA (AdS)

EIIlE (AdS)

ElIaE (MS)

EllaE (AdS)

EHaE (AdS)

tnhanctr(BPV-1)

E4 (tdtnovirus)

LI8 (RSV)

H. B. UDi ) /

finger sti•

50f 52

64 ?

85-90

40-45

43

31.8 / 1 CC

46 / nont

stnoms.tnuiwltt ts

KBFI lioust) ?

TFUD (HtLa) ?

CIF ?

CTF

CCAAT-bind.f.;

CTFjCEP ?

«TF/KF-1

KIP

NF-1:CCAAT-bind.f.;CBP (7)

EPF

r t f .

IB, 11013IB18IBIS, 1(0, 162

110, 162

3

64

5179

125125

64

766420

51

64

127, 129, 130

150

37

SOSO76, 7750, 163

179

293034-36

33, 34

32

32

32

32

17

33

149

1890



EFII

EF-C

(eibryo ONAbindingprotein)

EPBF

EPF

a(estrogenreceptor)

c-erb*

•factor 1"

•factor 2 1

•(actor 3'

factor i

f-EBP

c-fos geneproduct

6* factor

6AM

SCI

GCN4

ecRi

6HF-1

Eli(glucocorticoidreceptor)

quail

?

huian

soybean

louse

HeLa

chickenhuianrat

chicken

huian

rat

louse

•oust

louse

uuse

huian(HeLa)

louse

huian ?

yeast

rat

yeast

yeast

huian, rat

rat••1

•

•

•

•

chickenhuian

LTR (RSV)

Py C enhancerHBV enhancer ?

lectin

LTR <A-HuLV)

E2 <Ad3)

vitellogenin I !

growth honone

c-fos

c-fos

c-fos

LTR (MTV)

c-fos (enhancer)

iP2

E2a-LP (Ad2>

SALI-IO

6AL26M.7BAL80KEL1

growth honone

HIS3H1S4ILVIILV2

EN01, EKO2,TDHI, TDH2, TDH3

growth honone

GRgrowth hononeLTR (IDITV)lysozyie (chicken)•etallothionein I I

(huian)Ito-HuLV enhancer ?trp oiygenasetyr aainotransferaseuteroglobin (rabbit)viteltogenin I I

60

EIIA-EF

66 / 2 CC66.2/ 2 CC67 / 2 CC

46 / 2 CC T3 receptor

52SS

SRF (HeLa) ?

Spl (HeLa) ?

62

55 / none

99 / 1 CC

6HT-I

31 / none(atJ,?)

94 / none

SC2

/ 2 CC

94

149

13960

104

IS

35

173,181,1B4

185

iae18657

44

44

44

30

41

16,

37

43,46,4545,434S

59

61,616161

191

55

5456

106,105,109

12316416S169,174192,

174, 1B0182, 183

167

47, 4849, 188

49

62, 189,190

119-121106

170, 171

193

1891



ilSlSL

6T-!

GT-IIA

SMIB i

6T-I168

6T-1IC

H47F-1

H4TF-2

HAP

HAP1

HAP2

htat-inifiictdtutor

HtLa B factor

HiNF-A

HSTF

HSE-binding

prottin

IgPE-1

IjPE-2

IgPE-3

1TF

mi

IAC9

ur

IVl

LVb

IVc

soartt

pta

hutan(HtLa,BJA-B,rlOLT-4)

huian(HtLa,BJA-B,IIOLT-4)

huaan(HtLa,BJA-B,WHT-4)

huian(Htla)

huian(Htla)

huian(HtLa)

Orosophila

yiast

ytast

huian

hmanlHiU)

huian(KtLa)

Drosophilahuianytast

ytast

huun

•

•

huian

•oust

Kluyviro-

tyccs lact is

HiLa

•oust

•oust

IOUS»

c (r,( «. w. ( IDa l /

rbcS gtnts

tnhanctr (SV40)

tnhanctr (SV40)pE3 tot i f (IgH tnh. )

tnhanctr (SV40)

tnhancir (SV40)

bistom H4

hi stow H4

hsp70hsp83 (hsp82)

CYClCYC7

CYCl 29.B / nont

tlsp70

KHC class I H-2K"

histom K4

hsp70 (Dros., yeast)hsp70hsp83 (ytast , Dros.)

H S E ' I I TKS2 ISO

IgH tnhanctrtnhanctr (ItSV)

IgH tnhanctr

tnhanctr (LPV)

IgH tnhanctr

Hnt t r f t ron

KHC class I H-2K- 4B

02-iicroglobulin

lactost-galactost 97 / 1 CC

rtgulon

SV40 tnhanctr

Ito-ltuLV tnhanctr

Ho-KuLV tnhanctr

Ho-KuLV tnhanctr

synonvts,

toaivaltnts

HihT-A ?

HSTr

HSTF ?

H4TF-1 ?

HAP

h t a t - i n d . l . ?

HSTF ?

AP-2 (HtLa) ?

(«pl)

14S

9E

9696

96

96

65

65

7373

2224, 25

194

79

115

66, 67

71, 72, 757772

195

94

94

9494

94

102

114114

196, 197

153

123

123

123

1892



IMTil

BITF

NF-l

NF-A(IgNF-A)

NF-Al

KF-A2

NF- B

NF-pEl

KF-pE3

Nr-y

w-v

DBF

Octa-tactor

octaatr -b in-ding factor

oct-BIA

oct-BIB

ott-B2

ott-B3

p40-

PEA1

PEA2

PEB1

PS(progtsttronnttptor )

ytast

HtLi

haasttr

huaan

•oust;chicttn

•oust

rat

huaan,•onkty,•oust

huun

huaan B ctl ls

huian Bctl ls

(as NF-A)

(as NF-A)

•oust

•oust

sta urchin

huian

huain(rltLa)

huian(HtLa)

huian(BJA-B,ltOLI-4)

huian

(BJA-B,IIOLt-4)

huaanlHtla,BJA-B,rlulT-4)

HTIV-1

•oust

•oust

•oust

chicktnrabbit

hTal (0-boi)«F«2 "STF.3 •

AdIILP 46

HK6-C0A rtductast ?

IE 1 (CUV) S3surfact antigtn(KBV)L!R (miV)

a i d ) collagtnHo-KuLV tnhanttr ?albuain ?

Ig p tnhanctrIgH (VJ proaottrIg (VL) proiottr

Ig (VL) proaottrIgH (VJ proaottr

Ig (VL) proaottrIgH (VJ proaottr

Ig tnhanttr

Ig t tnhanctr

Ig p tnhanctr

KHC class I I El 1200

tk

histont H2B-1

U2 snRNA

inhanctr (SV40)112 snJNA ( I . l a t v i s )

tnhanctr (SV40)

inhanctr (SV40)

tnhanctr (SV40)

tnhanctr (SV40)

LTR 40

A tnh. (polyoaavirus)

A tnh. ( • • )

8 tnh. ( • • )

ly io iya t 110 / 2 CCuttroglobin 110Lie (MTV)lysoiyat (chicktn)

UEF; USF

CTFj I66CA-bind.prot.

oct-BIA, oct-BIB;NF-Al, KF-A2

(Ig)NF-A| oct-BIAoct-BIB 88

(Ig)NF-A

(Ig)NF-A ?

NF-Al

NF-AI

112112112

10, 15869

82, 83, 199131122

19, 20123

14

918686

, B8

B8B3

91

91

91

116, 117, 200

117

64

167

9797

161

161

161

161

201

132, 133

132, 133

133

103, 202, 203169, 170, 204106106

1893



factor

PRTF

PUF-I

qa-lF

Rl

R2

RAF

RC1

RC2

SBF-B

SBF-E

SCN-induciblefactor

Spl

SRF

T3 receptor

TAB

T-Ag(large Tantigen)

TF1IA

TFIIO

TGSCA-bindingprotein

TUT

sourtt

yeast

rat

Neurospora

crassa

huian

huian

yeast

yeast

yeast

yeast

yeast

louse

rniiin(H.La)

huianhuian(HeLa)

lousehuian(HeLa)•onkeyhuian(HeLa)huian(HeLa)huian(HeLa)

huian(HeLa)

huian(HeLa)

huian

huian(HtLa)

rat

Orosophila

SV40

HeLa

huian(HeLa)

chicken;•ouse

yeast

Ctne

HF«1 (P-boi)HFo2 "STE3 "

prolactin

qa gene cluster

6-interferon

6-interferon

CYC1

CYC1

CYC1

HHR

HML, HHR

c-fos (huian)

dhf reductase

douse)LTR (HIV-1)• e t a l l o t h i o m i n I I A•etallothionein I ?

EP (SV40)" •

c-Ha-rasltk (HSV)a4 (HSV-1)

1E-4/5 (HSV-1)

SI crystallin

(chicken) ?

U2 snRHA ?

actin (cytoskeletalI.laevis) ?

9-actin (rat) ?c-fos

growth horione

hsp70

hspB3 (hspB2)

proa./enh. (SV40)ori , EP, enh.(BPV)

AdHL

AdHL

hsp70 ?

LTR (MTV)

r ibosoia l proteins:L2S

f.. W. (kOa)/ srnonyps.

89 / 1 CC

105 1 •

•95

factor 1(Bouse), ?

67

55 / 2 CC c-erbA gene46 product

B factor ?

TAB (huun)?

/ 1 CH

100

120-140

TAB)B factor(Orosophila)?

NF-1

112112112

143

144

102

102

22

23

22, 23

70

70

40

27

68110, 111107154-156, 1561591451638585

205

167

4

242, 206

57, 58

7373

110, 15213B, 140

207

9

79

122

147

1894



(IEF

USF

USF I I

(vacciniavirusDM-bindingprottin)

VDR(vitai in Drtctptor)

X-box bin-ding prottin

Htlahaisttr

Htlahaisttr

huian

vacciniavirus

chicktn

toust

rp28RPSIA (2.1150S33S24-146

Ad2KlP 55 USF; KLTFHBS-Co* rtductast ?

AdlllP 55 UEF; RLTFHNS-CoA rtductast ?

E2a-LP (Ad2)

tarly proiottr 130

Ca-binding prottins 60 / 2 CC

HHC class 11 E:

14739, 147

147147

69'

9, 20869

37

172

209

116

gtne. otneproduct"'( re l . )

TFI1IA(210, 211)

Klin(212)

position

17

3B6899

13016018921S247

103131159187215243271

299

320349377405433461

499526554582610638

finatr stautnets

h 6 E K A LP V V Y KT 6 E KT G E KN I K I CT 0 g LA Gg gE K E R TE E g R

S A K Kg L g KT 6 E RI 6 E RT GE RT 8 E KS T HR

t E F R

N V A S SS R E KT 6 E RT G E KT B E KT G E R

T A N SS 6 E KI G EKI 6 EKT GE RI 6 E K

R 1 1 £ S F AP F P C KII F I £ 0

D C 6 A « V N K N U K ( 0 AE E S C . E K G F T S L K H I T R8 D

V 1 V C H F Etii I?

1 P C KI A V Iv r L c P

H EK D

D

G C. 0 I R F 1 T K A N H K KN £.6 K » f K K H N B I K VG C g K R F S L P S R 1 K RD S C S F V G K T U T 1 V IV C M R K F R H K O Y I R D

R 0 6 C g R S 1 T I A F N I R SP F V C.E H A

SH I IS H H Cp e g tP M C .P / R £.P C E tP 1 R £

p r s c.p u tp r a tP F KC_P f K t" I t

P H K £[ f l £P f K tP F P CPHK IP f P£

SP HV EL DS VP LS E

S KS HAESHSOT I

SKAEL Iy iS V? g

G C G K C F A K I E K S L E R

e i n s

K I C K« S L TI F NRH B F SA E K V

K H W A E» g K TN I B SI s v v

HT G K I F S C T A A VV R » 0R DC K K S F V g R S g F I K£ o KK f T E R S » ( V NC . Q K T F N g R S A l T Kt S K S F I B N S O l V KC . V K R F A E S S A 1 K KC . S R S F T H N S D 1 T A

C . R K T F K R U K S F L H( N K i M l H S D I Ht H K e F i g K s g i v KC . O K K F T E R S A I A KC S K E f T Q R S N t l LC. D R T F I g N S D 1 V K

£ . D L T f S H U S T F H KC.K K 6 / T 0 K 5 0 1 V KC . K K S F S O N S D 1 H KC 0 K S f T E B S » M KC . g K G F i g K S A l T KC e K S f l O N S D t V K

H a R Ta. Q R TJR R TILL R TI K R TJLKRK

1 0 0 1J F R TI L RT1 0 R T« 0 R I1 0 K V

I S K L11 RV0 U R I« H R T1 S R I1 0 R I

»F «

1i»

«

iii!L1ILI

IIIIII

i

iiiii

1895



Qtnt, Quit

PfOdtict'*'

Kr(213)

Kr h(214)

hb, fd 1(215)

Id 2

try-8(216)

uyl(216)

position

666694

722

744773801829857885913

941

98310011039

1067

1131115911B7121512431271

1299

217245273301329

235264292321

700728

160191219247275304

187217245273301330

398428

T G E KS 6 E K

N 6 E N

R S E PK T E KT G E RT G E RT G E KT G E KS R I KS E 0 N

A G E RT G E RT G E R

K N E S

K G T PT G E 9T 6 E KT G E KT G E RT G E K

N T G R

S R D KT G E KT G E KT G E RT G E K

T G E RT K E RT 8 E R

G K « KK P D KK N 9 KS S V Y

A A G AS C D D

F T E TO K S EE G K

< s

p r H £

nnp . , .

D ft P £R 1 P £P r H £PM£P C K £P f H £P f P £P ...

Sf K £P 1 K CPI*K£

P ...

R 1 SCp r T £P 1 A £P 1 T £p r K £P 1 G £

P Y ...

Sf T£P f E £t 1 H £PM£Pf E £

P F E £P 1 K £P H K £

HI K £I LO £P f 0 £O C R £

I t E £Vf K £

T E 1 P£O A T £T E L E £

U D K K K f g £0 A E E N A L I £9 T D R P R C P £

T K K RSK9E G K

V K O E £P NH I £T E K O C

U D K K K f 9 £E A E E N P 1 I £K EH R P R H Y £

S N D E N S G f CDVB

T EP9

T ENEPES 9E 9PDG V

N DSOG L

S EK ES TT VNENC

K IP ES HE !E R

E FD VS V

K TP KDKAD

K YNH

H 1N VR YDKE VPD

T TP IR YE KS IS V

L I

£ N K R f T E 6 8 8 I V K£ E K T f I 9 S S 0 1 V K

C 6 K V f H 0 R P A l l KCD K S f F 9 T S D 1 V K£ N K G M O N S D I V K£ D K G f I 9 R S A l T KC O K C f l B N S D l V K£ D K R / T E G S S ( I K£ 6 K S f S 0 S S N ( L K

C G K C / A H R S V 1 I K£ T R 5 f I 9 K 5 D l V KC E R S f V E K S A l S R

C 6 K C F T H R S V F L KC G K S f S 9 S S A ( V KC G K S f I 9 K S D 1 A KC G K K f l D R S S V V KC T K G f V 0 K S D L V KC D R S f S T H S A S V R

C S R S f G Y K H V 1 9 NC DK R f T R D H HI K T£D R 0 f V 9 V A N 1 R R£D G K1 S D S K 9 L K S£ H n K f R R R H H l K N

£H K L f S V K E D I 0V£ 6 R A f E H S 6 K ( H R£E K T f 1 9 S ...

C G V V A I T K V D F U A£ P F V T E F K H H I E Y£ S Y T C V N K S D 1 N S£ 0 Y A T K Y C K S F K L

£ O I F f K D A V L Y T l£ 8 E K C D 6 P V G 1 F V

C . G E H F S S 0 E V 1 E R£ G L K V K D D E V 1 D LC D K K f S H K f i N V L RC G E R f S L S U L N Y N£ H 0 g f K T K R T Y KH£ E K S f V D K Y T l K V

C 6 K V ? N S U V fl I 8 K£ 6 V I R R D E E Y [ E L£ P K S f S R P V N T L R£ G L R f S g D N L l Y N£ N V S f K S R K T F N H£ P K S f T E R Y W K H

C N T T f E N K K E l E H

» R R I1 1 VV

H L R T«L R TIB R T»« R T« 9 R I» 0 R I1 1 K C

« V R I» Y R T» 8 R V

« U R II« V R Ii g R i« S ft TH U R TI g R n

« E R TH U R L« L R VJ H L V1 K

1 Y R TH R R Ilit R I

D I R T1 1 R KI R K SI L R KYG

« R G Y1 R A RNA

« 1 K A D« n N ilit E VB L U R1 1 R T» K R V

1 I S E Ei K H LI M S S» R L R» T L Ilit K T

| L 0 F D

tt

1III1II

11I

IH

IIHC

I111C

III

1"11IIi

T C

1Iii££££I1

I

1896



.krl

(217)

ikr2(217)

115

143171199227255283311

214977105133161189217245

ADR(177)

GAL4(218)

PPR11219)

A6R RM(220)

LAC9(221, 222)

qi-lF(144)

LEU3

(223)

cER (180)

hER (183)

hGR (193)

hllR (224)

y- i rM (192)

cc-irbA (185)

ht-trbA (18E)

cPR (202, 203)vPR (204)

cVDR (209)

cERhER

98127

3

26

13

87

76

29

171177

413

595

294394

560

200206

S L V 0 P F V £ K r C 0 K T F 8 F K 9 L I V S « K R 1 HT 9 E K P f E £ 0V £ 0 I! T F S H K A II I I K « 0 R I IT 9 E K P F E £ PE £ 6 K A F T H 0 9 N I I V £ 9 R A IH E K K P y 9 £ SE £ G K A f T H Q S N [I V H 9 R I «T 6 E R P f E C HE C A K T F F K K S H M I J O K I »T S E K tVlC 8E C G K 9 F I g N 9 9 1 I I » R R T «T G E K till IE C 6 K T / S 0 R S I 1 R L « L li 1 »T G E K P C E C A E C G K

v g K K V / 6 £T 9 E K P M CTG E K P yK £I E E K tr itIG E K ?yK £T G E K P yE £T G E K tyE £T G E K t r ItT G E K ?rai

E C E K T F R 9 9 9 8 I I K DO R I IN V £D K H F ! E R 8 9 I T V H G R T »HE CG K A F S 9 9 UN 1K E C S K A f R K H S S tH D C E K A F 9 K N S S IHI £6 I! H F T 6 R 9 9 I T V « 0 V I «TE C G K A F S 9 9 A Y ID9 C 9 K A F 1 K N 9 9 1HE CG I! P F S R 9 T H I

V S O R T »g « E R i ig »R R I »

E » R R I HV « 0 R I I

!T £

S GK L R 9 F V £ E VT N E K P C P £ 91

£TR A F A I! g E H 1 K R if. Y R S «£ N R C F T R R D L 1 I R N D 1 I 1

L L 8 8 I E 9 A £ D I

G I 3 K 9 R T A £ KR

6 R A K T F T 8 £ U T

9 9 E V H H S A £ DA

C D Q

HAR K R K F A £ V E

E 9 T K E T R r £ A V

A

T T8P P PK L £ L V

6 S 8 R P 9K 1 £ IV

S Cl D K DE g £ VVY 9Y L

F E 9 IPg K 1 £ LII! I £ 9 V

200 K A F F K R S 1 0 6 H N D f H C PATN9

8

hSR 442 K V F F K li A V E 6 9 H H y I £ A8SKD

m 6 2 4 K V F T K R A V E 6 9 H N r L £ AGRKD

v-t rbA 58 K S F F R R I 1 0 I! N L H P T r S £ TYD8Ccc-trbA 72 6 K D Cbc-trbA 123 6 S K E K

£ R L K K L K C 8 K E K P K C AK C

£ R L K K I K C D g E F P 9 C KR C

£RG R K V K C D L R H P H C 9 R C

£RK K K g K C S K T V P T C IK C

£ R A A * E K C D 6 i g P A C FP C

£ g g K 8 K C D A H ERA PEP C T K C

£ H D Y A 8 6 Y H V 6 V g 3 C E6 C

£ 8 D E A 8 9 C H Y 6 V L T C 6 5 C

£ 8 0 E A 9 G C H Y 6 V V T C 88 C

£90 K A T 9 Y HY R C 1 T C E 6 C

£ G 0 E A S 6 C H V G V L T C 6S C

£ 8 D R A T G F H F N A H T C E8 C

£ T 1 D K N R R K 9 C 9 A C R L R K C

£ 1 I O K I R R K N C P A C R Y R K C

£ I I D K I R R K N C P A C R L 9 K C

C V 1 D K I T R M 0 C 0 L C R F K K CI LV E

1897



cn# . oeneproduct1 ' '

c/rPR

cVDR

EIA (179)

position

5B9

146

K V F

K G F

F

F

( in

K R A B E 6 0

R R S H K R K

V V

aer «

UN

AD

EN P

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References1. Walsh, K. and Schiaael, P. (1997) J. Bio]. Chen. 262, 9429-9432.

2. Greenberg, M.E. et a l . (1987) Nol. Cell. Biol. 7, 1217-1225.3. Parker, C.S. and Topol, J. (1984) Cell 36, 357-369.4. Nohun, T. et a l . (1987) EHB0 J. 6, 667-673.5. Noncollin, V, et a l . (1986) EHBO J. 5, 2577-25B4.6. rliyaioto, N.6. et a l . (1985) EflBO J. 4, 3563-3570.7. Lennard, A.C. and Egly, J.M. (1987) EMBO J. 6, 3027-3034.

8. Shi, X.-P. et a l . (1986) Nucleic Acids Res. H , 3729-3744.9. Savadogo, M. and Roeder, R.6. (1985) Cell 43, 165-175.

10. Cartheu, R.U. et a l . (1985) Cell 43, 439-448.

11. Heberlein, U. et a l . (19B5) Cell 41, 965-977.12. Ferl, R.J. and Nick, H.S. (1987) J. Biol. Chea. 262, 7947-7950.13. Beier, D.R. et a l . (1985) Nol. Cell. Biol. 5, 1743-1749.14. Cereghini, S. et a l . (1987) Cell 50, 627-638.15. Flaaant, F. et a l . (1987) Nol. Cell. Biol. 7, 3548-3553.

16. Distel, R.J. et a l . (1987) Cell 49, 835-844.17. Hoskaluk, C. and Bastia, D. (1907) Proc. Natl. Ac ad. Sci. USA 84,1213-1218.18. Iugava , N. et a l . (1987) Cell 51, 251-260.19. Hataiochi, A. et a l . (1986) J. Biol. Chea. 261, 11310-11314.20. Oikarinen, J. et a l . (1987) J. Biol. Chea. 262, 11064-11070.

21. Angel, P. et a l . (1987) Cell 49, 729-739.

22. Pfeifer, K. et a l . (1987) Cell 49, 9-18.

23. Drcangioli, B. and Lescure, B. (1985) EHBO J. i , 2627-2633.24. Pfeifer, K. et a l . (1987) Cell 49, 19-27.

25. Prejant, T. ii a l . (1987) Nol. Cell . Biol. 7, 3252-3259.

26. Shiiada, T. et a l . (1986) J. Biol. Chea. 2M, 1445-1452.27. Dynan, U.S. et a l . (1986) Nature 319, 246-248.28. Barrett, P. et a l . (1987) Nucleic Acids Res. H , 2719-2735.

29. Kovesdi, I . et a l . (1987) Proc. Natl. Acad. Sci. USA B4, 2180-2184.30. Cordingley, H.6. et a l . (1987) Cell 48, 261-270.31. Boeuf, H. et a l . (1987) Nucleic Acids Res. 15, 509-527.

32. Jalinot, P. t t a l . (1987) Nol. Cell. Biol. 7, 3806-3817.

33. SivaRaaan, L. et a l . (1986) Proc. Natl. Acad. Sci. USA 83, 5914-5918.34. SivaRaaan, L. and Thiaaappaya, B. (1987) Proc. Natl. Acad. Sci. USA 84,6112-6116.

35. Yee, A.S. et a l . (1987) EHBO J. 6, 2061-2068.

1 8 9 8



36. Jalinot, P. et al. (1987) Hoi. Cell. Biol. 7, 3806-3817.37. Goding, C.R. et al. (19B7) Nucleic Acids Res. 15, 7761-7780.38. Lee, K.A.U. and 6reen, H.R. (1987) ENBO J. 6, 1345-1353.39. Hutt, J. »t al. (19B5) EMBO J. 4, 3539-3547.40. Hayes, T.E. et al. (1987) Proc. Natl. Acad. Sci. USA 84, 1272-1276.41. Pryues, R. and Roedtr, R.G. (19B7) Hoi. Cell. Biol. 7, 3482-3489.42. Treis»an, R. (1986) Cell 46, 567-574.43 . F i s c h , T.H. et a l . (1987) Hoi. C e l l . B i o l . 7, 3490-3502 .4 4 . G i l i a n , H.Z. et a l . (1986) Hoi. C e l l . B i o l . 6 , 4305-4316 .4 5 . Brai , R.J. et a l . (1986) EMEO J. 5 , 603-608 .46 . S e l l e c k , 5 .B . and Majors, J, (1987) Nature 325, 173-177.47 . S i n i g e r , E. et a l . (1985) Cell 40 , 767-774 .48 . S e l l e c k , S.B. and Hajors, J .E . (1987) Hoi. C e l l . B i o l . 7, 3260-3267 .49 . Bra«, R.J. and Kornberg, R.D. (19B5) Proc. Nat ! . Acad. S c i . USA 82 , 43-4750 . J o n e s , K.A. et a l . (1987) Cell 48 , 79 -89 .5 1 . Cohen, R.B. et a l . (1986) Hoi. C e l l . B i o l . 6, 821-832 .5 2 . Keiper, 8. e t a l . (1987) Hoi. C e l l . B i o l . 7, 2059-2069 .5 3 . E i e r s o n , B.H. et a l . (19B5) Cell 4 1 , 2 1 - 3 0 .5 4 . Okret, S. et a l . (1936) Proc. N a t l . Acad. S c i . USA 83 , 5899-5903 .55 . Lefevre , C. e t a l . (1987) EHBO J. 6 , 9 7 1 - 9 8 1 .56 . Hoore, D.O. e t a l . (1985) Proc. N a t l . Acad. S c i . USA 8 2 , 6 9 9 - 7 0 2 .57 . Ve, Z . - S . and S a t u e l s , H.H. (1987) J. B i o l . Che». 262, 6313-6317 .58 . Koenig, R.J. et a l . (1987) Proc. Nat l . Acad. S c i . USA 84 , 5670-5674 .59 . Uest , B.L. e t a l . (19B7) Hoi. C e l l . B i o l . 7, 1193-1197.60 . Shaul , Y. and Ben-Levy, R. (1987) EHBO J . 6 , 1913-1920.6 1 . Arndt, K. and Fink, G.R. (1986) Proc. N a t l . Acad. S c i . USA 83 , 8516-8520.6 2 . Hope, I .A. and S t r u h l , K. (1985) Cel l 43 , 177-188.63 . S i v e , H.L. and Roeder, R.G. (1986) Proc. N a t l . Acad. S c i . USA 8 3 , 6382-6386.64 . B a r b e r i s , A. et a l . (19B7) Cell 50 , 347-359 .65 . Oa i l ey , L. et a l . (1986) Proc. N a t l . Acad. S c i . USA 83 , 7241-7245 .66 . P a u l i , U. et a l . (1987) Sc ience 236, 1308-1311 .67 . van Ui jnen , A . J , et a l . (1987) Nucle ic Acids Res . 15, 1679-1698.68 . Jones , K.A. e t a l . (1986) Sc ience 232 , 755-759 .69 . Osborne, T.F. et a l . (1987) Proc. Nat l . Acad. S c i . USA 84 , 3614-3618 .70 . Shore, D. e t a l . (1987) EHBO J . 6 , 4 6 1 - 4 6 7 .7 1 . Topol, J. et a l . (1985) Cell 42, 527-537 .72 . U iederrecht , G. et a l . (19B7) Cell 48 , 507 -515 .73 . Uu, C. (1984) Nature 3_09_, 229-234 .74. Parker, C.S. and Topol, J. (1984) Cell 37, 273-2B3.75. Shuey, D.J. and Parker, C.S. (1986) J. Biol. Chet. 2 H , 7934-7940.76. Greene, J.H. et al. (1987) Hoi. Cell. Biol. 7, 3646-3655.77. Morgan, U.D. et al. (1987) Hoi. Cell. Biol. 7, 1129-1138.78. Kingston, R.E. et al. (1967) Hoi. Cell. Biol. 7, 1530-1534.79. Uu, B.J. et al. (1987) Proc. Natl. Acad. Sci. USA 84, 2203-2207.80. Uu, C. (1984) Nature 3Ji, 81-84.81. Levinger, L.F. and Lautenberger, J.A. (1987) Eur. J. Biochei. 166, 519-526.82. Hennighausen, L. and Fleckenstein, B. (1966) EHBO J. 5, 1367-1371.83. Ghaial, P. et a l . (1987) Proc, Natl. Acad. Sci . USA 84, 3658-3662.84. Krist ie , T.H. and Roizian, B. (1986) Proc. Natl. Acad. Sci . USA 83,

4700-4704.85. Jones, K.A. and Tjian, R. (1985) Nature 317, 179-182.86. Singh, H. tt a l . (1986) Nature 319, 154-158.87. Ballard, D.U. and Bothwell, A. (19B6) Proc. Natl. Acad. Sci . USA 83, 9626-9630.88. Staudt, L.H. et a l . (1986) Nature 321, 640-643.89. Landolli, N.F. et a l . (1986) Nature 323, 548-551.90. Peterson, C.L. et a l . (1986) Hoi. Cell . Biol. 6, 4168-4178.91. Sen, R. and Balt i iore, D. (1986) Cell 46, 705-716.

1 8 9 9



92. "einberger, J. et a!. (1986) Nature 322, 846-848.93. Ephrusst, A. et a l . (1987) Science 227, 134-140.94. Schlokat, U. et a l . (19B6) EHBO J. 5, 3251-3258.95. Augereau, P. ind Chaabon, P. (1986) EHBO J. 5, 1791-1797.96. Xiao, J.H. et a l . (1987) EMBO J. 6, 3005-3013.97. Bohaann, D. et a l . (1987) Nature 325, 268-272.98. Davidson, I. et a l . (1986) Nature 323, 544-548.99. Haeda, H. et a l . (1987) Nucleic Acids Res. 15, 2851-2869.

100. S iable , J.H. et a l . (1987) Hoi. Cell, B io l . 7, 1815-1822.101. Ohlsson, H. and Edlund, T. (1986) Cell 45, 35-44.102. Zinn, K. and Haniatis , T. (1986) Cell 45, 611-618.103. Xanthoudakis, S. and Hi s c o t t , J. (1987) J. Bio l . Chen. 262, 8298-8302.104. Jofuku, K.D. et a l . (1987) Nature 328, 734-737.105. von der Ahe, D. et a l . (1986) Proc. Natl . Acad. Sci . USA 83, 2817-2821.106. von der Ahe, D. et a l . (1985) Nature 311, 706-709.107. Seguin, C. and Haaer, D.H. (1987) Science 235, 1383-1387.108. Andersen, R.D. et a l . (1987) Hoi. Cell. Biol . 7, 3574-3581.109. Karin, H. et a l . (1984) Nature 308, 513-519,110. Mitchel l , P. et a l . (1987) Cell 50, 847-861.111. Lee, U. et a l . (1987) Nature 325, 368-372.112. Bender, A. and Sprague, 6.F. j r . (1987) Cell SO, £81-691.113. I s rae l , A. et a l . (1987) Proc. Natl. Acad. Sc i . USA 84, 2653-2657.114. Yano, 0. et a l . (1987) EMBO J. 6, 3317-3324.115. Baldwin, A.S. and Sharp, P.A. (1987) Hal. Cel l . Biol . 7, 305-313.116. Dorn, A. et a l . (19B7) Proc. Natl . Acad. Sci . USA 84, 6249-6253.117. Dorn, A. et a l . (1987) Cell 50, 863-872.118. Hiva, K. and Stroainger, J.L. (1987) Nucleic Acids Res. 15, 8057-8067.119. Payvar, F. et a l . (1983) Cell 35, 381-392.120. Scheidere i t , C. and Beato, H. (1984) Proc. Nat l . Acad. Sci . USA Bl, 3029-3033.121. Sche idere i t , C. et a l . (1983) Nature 301, 749-752.122. Nouock, J. et a l . (1985) Nucleic Acids Res. H , 2045-2061.123. Speck, N.A. and Balt iaore, D. (19B7) Hoi. Cel l . Biol . 7, 1101-1110.124. van der Hoorn, F. (1987) J. Hoi. Biol. 193, 255-266.125. firaves, B.J. et a l . (1986) Cell 44, 565-576.126. Johnson, P.F. et a l . (1987) Genes i Oevelopaent L 133-146.127. Sagaai, I. et a l . (1986) Hoi. Cell . B i o l . 6, 4259-4267.128. Elbrecht, A. et a l , (1985) DNA £, 233-240.129. Pastorc ic , H. et a l . (1986) Hoi, Cell. Biol , 6, 2784-2791.130. Tsai , S.Y. et a l . (1987) Cell 52, 701-709.131. Stanway, C. et a l . (1987) Nucleic Acids Res. 15, 6855-6873.132. P i e t t e , J. and Yaniv, H. (1987) EHBO J . 6, 1331-1337.133. Kryszke, H.-H. et a l . (1987) Nature 326, 254-256.134. P i e t t e , J. et a l . (1985) EHBO J. 4, 2675-2685.135. P i e t t e , J. and Yaniv, H. (1986) Nucleic Acids Res. H , 9595-9611.136. Boehnlein, E. and 6russ, P. (1986) Hoi. Cel l . Biol . 6, 1401-1411.137. Fujiaura, F.K. (19B6) Nucleic Acids Rts . U , 2845-2861.138. Cowie, A. and Kaien, R. (1984) J. Virol . & 750-760.139. Ostapchuk, P, et a l . (1986) Proc. Natl . Acad. Sci . USA 83, 8550-8554.140. Dilworth, S.H. et a l . (1984) Proc. Nat l . Acad. Sc i . USA i i , 1941-1945.141. 6utierrez-Hartaann, A. et a l . (1987) Proc. Nat l . Acad. Sci . USA 84 5211-5215.142. E l sho l tz , H.P. et a l . (1987) Science 234, 1552-1557.143. Cao, I, et a l , (1987) Hoi. C e l l . Biol . 7, 3402-3408.144. Baua, J.A. et a l . (1987) Hoi. Cell . B i o l . 7, 1256-1266.145. I s h i i , S. et a l . (1986) Science 232, 1410-1413.146. Green, P.J. et a l . (1987) EHBD J. 6, 2543-2549.147. Vignais , H.-L. et a l . (1987) EHBO J. 6 , 1451-1457.148. Huet, J. and Sentenac, A. (1987) Proc. Natl. Acad. S c i . USA 84, 3648-3652.

1900



149. Sealy, L. and Chalkley, R. (1987) Hoi. Cell. Biol. 7, 7B7-798.150. Hontsiny, H.R. and Bilezikjian, L.H. (1987) Nature 328, 175-178.151. Shaul, V. et al. (1986) EMBO J. 5, 1967-1971.152. DeUcia, A.L. et al. (1983) J. Virol, 46, 143-150.153. Kia, C.H. et al. (1987) Proc. Natl. Acad. Sti. USA gj, 6025-6029.154. Oynan, H.S. et al. (1985) Proc. Natl. Acad. Sci. USA 82, 4915-4919.155. 8idoni, D. et al. (1985) Science 230, 511-517.156. Gidoni, D. et al. (1984) Nature 312, 409-413.157. Briggs, H.R. et al. (1986) Science 234, 47-52.158. Oynan, y.S. and Tjian, R. (1983) Cell 35, 79-87.159. Buchanan, R.L, and 6ralla, J.D. (1987) Hoi. Cell. Biol. 7, 1554-1558.160. Uildeaan, A.G. et al. (1986) Hoi. Cell. Biol. 6, 2098-2105.161. Rosales, R. et al. (19B7) EHBO J. 6, 3015-3025.162. Chiu, R. et al. (1987) Nature 329, 648-651.163. Jones, K.A. et al. (1985) Cell 42, 559-572.164. Danesch, U, et al. (1987) EHBO J. 6, 625-630,165. Jantzen, H.-H. et al. (1987) Cell 49, 29-3B.166. Ciliberto, 6. et al. (1987) Nucleic Acids Res. 15, 2403-2416.167. Janson, L. et al. (1987) Nucleic Acids Res. U , 4997-5016.168. Kaziaier, H. et al. (1937) EHBO J. 6, 3071-3078.169. Jantzen, K. et al. (1987) Nucleic Acids Res. 15, 4535-4552.170. Bailly, A. et al. (1986) EHBO J. 5, 3235-3241.171. Cato, A.C.B. et al. (19B4) EHBO J. 3, 2771-2778.172. Yuen, I. et al. (1987) Proc. Natl. Acad. Sci. USA 84, 6069-6073.173. Jost, J.-P. et al. (1984) Proc. Natl. Acad. Sci. USA IM, 429-433.174. Saluz, H.P. et al. (1986) Proc. Natl. Acad. Sci. USA 83, 7167-7171.175. Lubon, H. and Hennighausen, L. (1987) Nucleic Acids Res. 15, 2103-2121.176. Morse, L.S. et al. (1978) J. Virol. 2£, 389-410.177. Hartshorne, T.A. et al. (1986) Nature 320, 283-287.178. Lee, H. et al. (1987) Cell 49, 741-752.179. Noran, E. and Hathews, fl.B. (19B7) Cell 48, 177-178.160. (trust, A. et a l . (1986) EHBO J. 5, 891-897.181. Walter, P. et a l . (1985) Proc. Natl . Acad. Sci. USA 82, 7839-7893.182. Green, S. et a l . (1986) Nature 320, 134-139.183. 6reene, 6.L. et a l . (19B7) Science 231, 1150-1154.184. Koike, S. et a l . (1987) Nucleic Acids Res. H 2499-2513.135. Sap, J. et a l . (19B6) Nature 324, 635-640.186. Weinberger, C. et a l . (1936) Nature 324, 641-646.187. Curran, T. et a l . (1984) Cell 36, 259-268.188. laughon, A. and 6esteland, R.f. (1934) Hoi. Cel l . Biol. i , 260-267.1B9. Hope, I.A. and Struhl, K. (1986) Cell 46, 885-894.190. H i l l , D.E. et a l . (1986) Science 234, 451-457.191. Holland, M.J. et a l . (19B7) Hoi. Cel l . Biol. 7, 813-620.192. Ueinberger, C. et a l . (1985) Nature 318, 670-672.193. Hollenberg, S.H. et a l . (19B5) Nature 31B, 635-641.194. Pinkhai, J.L. et a l . (1987) Hoi. Cel l . Biol. L 578-585.195. Sorger, P.K. and Pelhaa, H.R.B. (1987) EHBO J. 6, 3035-3041.196. Uray, L.V., j r . et a l . (1987) Hoi. Cel l . Biol. 7, 1111-1121.197. Salaeron, J .H . , j r . and Johnston, S.A. (1986) Nucleic Acids Res. 14, 7767-7781.198. Chodosh, L A . et a l . (1986) Hoi. Cel l . Biol . 6, 4723-4733.199. Rosenfeld, P.J. and Kelly, T.J. (1986) J. Biol. Chei. 261, 1398-1408.200. Hooft van Huijsduijnen, R.A.H. et a l . (1987) Nucleic Acids Res. 15, 7265-7282.201. Seiki , H. et a l . (1986) EHBO J. 5, 561-565.202. Conneely, O.H. et a l . (1986) Science 233, 767-770.203. Jeltsch, J.H. et a l . (1986) Proc. Nat l . Acad. Sci. USA 83, 5424-542B.204. Loosfelt, H. et a l . (1986) Proc. Natl . Acad. Sci. USA 83, 9045-9049.

1 9 0 1



2 0 5 . Das, G.C. and P i a t i g o r s k y , J . (I9B6! Proc . N a t l . Acad, S c i . USA 8 3 , 3131 -3135 .206 . T r e i s i a n , R. (1987) EI1B0 J. 6, 2711-2717 .2 0 7 . Reinberg , D. e t a l . (1987) J . B i o l . Che i . 262 , 3322 -3330 .208 . Hough, P .V.C. et a l . (19B7) Proc . Nat l . Acad. S c i . USA 84 , 4B26-4B30.2 0 9 . McDonnell, D.P. et a l , (1987) S c i e n c e 2 3 5 , 1214-1217,2 1 0 . Ginsberg , A.H. e t a l . (19B4) Cel l 39, 4 7 9 - 4 8 9 .2 1 1 . M i l l e r , J. e t a l . (1985) EHBO J. 4 , 1609-1614 .2 1 2 . Ruij i A l taba , A. et a l . (1987) EHBO J. 6, 3065-3070 .2 1 3 . Rosenberg, U.B. et a l . (1986) Nature 3 1 2 , 3 3 6 - 3 3 9 .214 . Schuh, R. et a l . (1986) Ce l l 47 , 1025-1032 .2 1 5 . Tautz, D. et a l . (1987) Nature 327 , 3 8 3 - 3 8 9 .216 . V incent , A. et a l . (1985) J. Hoi . B i o l . 186, 149-166 .2 1 7 . Chowdhury, K. et a l . (1387) Ce l l 48 , 7 7 1 - 7 7 8 .2 1 8 . Laughon, A. and G e s t e l a n d , R.F. (1984) Hoi . C e l l . B i o l . 4 , 260 -267 .2 1 9 . Kanoerer, B. et a l . (1984) J . Hoi. B i o l . 180, 2 3 9 - 2 5 0 .2 2 0 . Nessenguy, F. et a l . (1986) Eur. J . Biochen . 157, 7 7 - 8 1 .2 2 1 . Uray, L . V . , j r . e t a l . (1987) Hoi . C e l l . B i o l . 7 , 1111-1121.2 2 2 . S a l n e r o n , J . H . , j r . and Johns ton , S.A. (19B6) Nuc le i c Acids Res . H , 7 7 6 7 - 7 7 8 1 .2 2 3 . Fr iden , P. and S c h i m e l , P. (1987) Hoi. C e l l . B i o l . 7, 2708-2717 .2 2 4 . Arr i za , J . L . et a l . (1987) S c i e n c e 237, 2 6 8 - 2 7 5 .

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Compilation of transcription regulating proteins