Alexanderwerk AG Kippdorfstraße 6 – 24 42857 Remscheid P+49 (0)2191 79 50 F +49 (0)2191 79 53 50 imaschinen@alexanderwerk.com www.alexanderwerk.comNo liability will be accepted for errors or omissions. Subject to change (246-2825)

Containment in Pharmaceutical Production

Compactors and GranulatorsWP 150 Pharma

Compactors and Granulators for use in the pharmaceutical Industry, made by Alexanderwerk

Roller Compactor BT 120 PharmaFor laboratory and special uses, with a throughput of up to 8 kg/hr.

Roller Compactor WP 120 PharmaA compactor and granulator for special products, frequent product changes and small batches, for use in the laboratory or the lower production range; with a throughput of up to 40 kg/hr.

Roller Compactor WP 150 PharmaA compactor and granulator for use in the pharmaceutical industry; with a throughput of up to 150 kg/hr.

Roller Compactor WP 200 PharmaA compactor and granulator for use in production; with a throughput of up to 250 kg/hr.

Roller Compactor WP 200 C1For highest requirements in pharmaceutical production; with a throughput of up to 250 kg/hr.

CAD data show the WP 150 Pharma

Technical Data

Throughput, continuous operation up to 150 kg/hr.

Granulate material size variable

Maximum pressing force 20 kN/cm of roller width

Installed power approx. 8 kW

Weight approx. 1,700 kg (complete, excluding control system)

Metallic materials 1.4571 (entirely)

Compacting rollers 1.4122

Rotary shaft seals, in contact with the material Polytetrafluoroethylene (PTFE, Teflon) FDA-approved

www.fa

berm

olde

nhau

er.de

The Containment Specialist WP 150 Pharma

The WP 150 Pharma roller compactor made by Alexan-derwerk is a compactor and granulator designed for use in the pharmaceutical industry. With its sealing sy-stem customized for containment and a throughput of up to 150 kg/hr., it is about the finest machine when it comes to compacting or granulating highly efficient preparations. Since the 1950s, Alexanderwerk has been developing and producing roller compactors for use in the chemical or primary industries. With the WP 150 Pharma, Alexanderwerk has now complemented its roller com pa ctor production series with a containment machine. The WP 150 Pharma combines the design principles of the “standard“ roller compactors made by Alexanderwerk with the requirements made of a containment machine:

Containment Sealing SystemThe proportions of highly active substances in phar-maceutical preparations is continuously rising. To ensure operators or other such personnel do not get in contact with these active ingredients, it is imperative to have a production environment free from any dust, viz. containment. A special containment sealing system has been developed for the WP 150 Pharma so as to guarantee separation between the processing cham-ber and the machine operator or the environment respectively.

The processing chamber is tightly bolted by means of eight handles, and can be monitored at any time through the transparent front panel.

With the WP 150 Pharma, Alexanderwerk adds to the series of roller compactors a containment machine for processing highly active preparations (with a throughput of up to 150 kg/hr.).

321

8

7

109

13

4 6

1211

5

Front of the WP 150 Pharma

•partitionbetweenproductandoperatorsorthe environment respectively•cGMPdesign•physicalseparationofprocessengineering equipment and drive units•minimumfeedratesofupto1r.p.m.available from servo motor•amplydimensionedsingle-stagerotorfine granulation using the D design•madecompletelyofstainlesssteel•allnon-metallicmaterialsdesignedaccordingto FDA requirements•URS-compliantdesign•processchamberweldedattherear•sealingsystemoptimizedforcontainment•PLCautomated•optional:WIP•optional:21CFRPart11•optional:insulator•optional:PAT

RFG Granulating ModuleAfter compaction in the roller compactor, there is a downstream crushing step. This step is also known as degrading granulation. This is where rotor fine granu-latorsoftheRFGmodelmadebyAlexanderwerkareused. As opposed to the WP 120 roller compactors, this granulating module is of a single-stage design, and of larger dimensions accordingly. Again, the modular design is typical of Alexanderwerk. Process- related components such as screen baskets or cleats are easy to remove or replace without any special tools.Inthisway,differentmeshsizes,perforatedplates or square wire mesh may be used. Alexander-werk offers strainers with mesh openings of between 0.5 mm and 10 mm.

Applications

Pharmaceutical companies the world over have been using roller compactors made by Alexanderwerk for years, for example in the production of pills, capsules, Life-Scienceproducts,flavoringagents,instantpowders,artificial sweeteners or toners.

Examples of Granules

Antibiotics

Riboflavin

Acetylsalicylic acid

Ibuprofen

Lactose

Cephalosphorin

Defined grinding or shredding occurs in the single-stage RFG granulating module made by Alexanderwerk.

Custom-made designs or special housings and individual adapta-tions to the WP 150 Pharma are available at any time.

Optionally, the WP 150 Pharma can be supplemented with an environment-friendly recooling unit.

1 Vent for displaced air and at the same time filler for undersize and/or oversize respectively

2 Filler for raw product

3 Nozzle for level sensor

4 Feeder hopper using the Combi-Vent-Feeder® design

5 Roller compactor compacting unit

6 Cake breaker for precrushing

7 Amply dimensioned single-stage granulating unit

8 Outer casing; behind it the worm feeder

9 Casing for the processing chamber, circumferentially welded to the back panel

10 Transparent cover for the processing chamber, gaskets in a containment design, bolted to eight handles made of stainless steel

11 Nozzle for sampling

12 Nozzle for granulate material outlet

13 Pivoted LCD touch screen as an operating unit

The Containment Specialist WP 150 Pharma

The WP 150 Pharma roller compactor made by Alexan-derwerk is a compactor and granulator designed for use in the pharmaceutical industry. With its sealing sy-stem customized for containment and a throughput of up to 150 kg/hr., it is about the finest machine when it comes to compacting or granulating highly efficient preparations. Since the 1950s, Alexanderwerk has been developing and producing roller compactors for use in the chemical or primary industries. With the WP 150 Pharma, Alexanderwerk has now complemented its roller com pa ctor production series with a containment machine. The WP 150 Pharma combines the design principles of the “standard“ roller compactors made by Alexanderwerk with the requirements made of a containment machine:

Containment Sealing SystemThe proportions of highly active substances in phar-maceutical preparations is continuously rising. To ensure operators or other such personnel do not get in contact with these active ingredients, it is imperative to have a production environment free from any dust, viz. containment. A special containment sealing system has been developed for the WP 150 Pharma so as to guarantee separation between the processing cham-ber and the machine operator or the environment respectively.

The processing chamber is tightly bolted by means of eight handles, and can be monitored at any time through the transparent front panel.

With the WP 150 Pharma, Alexanderwerk adds to the series of roller compactors a containment machine for processing highly active preparations (with a throughput of up to 150 kg/hr.).

321

8

7

109

13

4 6

1211

5

Front of the WP 150 Pharma

•partitionbetweenproductandoperatorsorthe environment respectively•cGMPdesign•physicalseparationofprocessengineering equipment and drive units•minimumfeedratesofupto1r.p.m.available from servo motor•amplydimensionedsingle-stagerotorfine granulation using the D design•madecompletelyofstainlesssteel•allnon-metallicmaterialsdesignedaccordingto FDA requirements•URS-compliantdesign•processchamberweldedattherear•sealingsystemoptimizedforcontainment•PLCautomated•optional:WIP•optional:21CFRPart11•optional:insulator•optional:PAT

RFG Granulating ModuleAfter compaction in the roller compactor, there is a downstream crushing step. This step is also known as degrading granulation. This is where rotor fine granu-latorsoftheRFGmodelmadebyAlexanderwerkareused. As opposed to the WP 120 roller compactors, this granulating module is of a single-stage design, and of larger dimensions accordingly. Again, the modular design is typical of Alexanderwerk. Process- related components such as screen baskets or cleats are easy to remove or replace without any special tools.Inthisway,differentmeshsizes,perforatedplates or square wire mesh may be used. Alexander-werk offers strainers with mesh openings of between 0.5 mm and 10 mm.

Applications

Pharmaceutical companies the world over have been using roller compactors made by Alexanderwerk for years, for example in the production of pills, capsules, Life-Scienceproducts,flavoringagents,instantpowders,artificial sweeteners or toners.

Examples of Granules

Antibiotics

Riboflavin

Acetylsalicylic acid

Ibuprofen

Lactose

Cephalosphorin

Defined grinding or shredding occurs in the single-stage RFG granulating module made by Alexanderwerk.

Custom-made designs or special housings and individual adapta-tions to the WP 150 Pharma are available at any time.

Optionally, the WP 150 Pharma can be supplemented with an environment-friendly recooling unit.

1 Vent for displaced air and at the same time filler for undersize and/or oversize respectively

2 Filler for raw product

3 Nozzle for level sensor

4 Feeder hopper using the Combi-Vent-Feeder® design

5 Roller compactor compacting unit

6 Cake breaker for precrushing

7 Amply dimensioned single-stage granulating unit

8 Outer casing; behind it the worm feeder

9 Casing for the processing chamber, circumferentially welded to the back panel

10 Transparent cover for the processing chamber, gaskets in a containment design, bolted to eight handles made of stainless steel

11 Nozzle for sampling

12 Nozzle for granulate material outlet

13 Pivoted LCD touch screen as an operating unit

The Containment Specialist WP 150 Pharma

The WP 150 Pharma roller compactor made by Alexan-derwerk is a compactor and granulator designed for use in the pharmaceutical industry. With its sealing sy-stem customized for containment and a throughput of up to 150 kg/hr., it is about the finest machine when it comes to compacting or granulating highly efficient preparations. Since the 1950s, Alexanderwerk has been developing and producing roller compactors for use in the chemical or primary industries. With the WP 150 Pharma, Alexanderwerk has now complemented its roller com pa ctor production series with a containment machine. The WP 150 Pharma combines the design principles of the “standard“ roller compactors made by Alexanderwerk with the requirements made of a containment machine:

Containment Sealing SystemThe proportions of highly active substances in phar-maceutical preparations is continuously rising. To ensure operators or other such personnel do not get in contact with these active ingredients, it is imperative to have a production environment free from any dust, viz. containment. A special containment sealing system has been developed for the WP 150 Pharma so as to guarantee separation between the processing cham-ber and the machine operator or the environment respectively.

The processing chamber is tightly bolted by means of eight handles, and can be monitored at any time through the transparent front panel.

With the WP 150 Pharma, Alexanderwerk adds to the series of roller compactors a containment machine for processing highly active preparations (with a throughput of up to 150 kg/hr.).

321

8

7

109

13

4 6

1211

5

Front of the WP 150 Pharma

•partitionbetweenproductandoperatorsorthe environment respectively•cGMPdesign•physicalseparationofprocessengineering equipment and drive units•minimumfeedratesofupto1r.p.m.available from servo motor•amplydimensionedsingle-stagerotorfine granulation using the D design•madecompletelyofstainlesssteel•allnon-metallicmaterialsdesignedaccordingto FDA requirements•URS-compliantdesign•processchamberweldedattherear•sealingsystemoptimizedforcontainment•PLCautomated•optional:WIP•optional:21CFRPart11•optional:insulator•optional:PAT

RFG Granulating ModuleAfter compaction in the roller compactor, there is a downstream crushing step. This step is also known as degrading granulation. This is where rotor fine granu-latorsoftheRFGmodelmadebyAlexanderwerkareused. As opposed to the WP 120 roller compactors, this granulating module is of a single-stage design, and of larger dimensions accordingly. Again, the modular design is typical of Alexanderwerk. Process- related components such as screen baskets or cleats are easy to remove or replace without any special tools.Inthisway,differentmeshsizes,perforatedplates or square wire mesh may be used. Alexander-werk offers strainers with mesh openings of between 0.5 mm and 10 mm.

Applications

Pharmaceutical companies the world over have been using roller compactors made by Alexanderwerk for years, for example in the production of pills, capsules, Life-Scienceproducts,flavoringagents,instantpowders,artificial sweeteners or toners.

Examples of Granules

Antibiotics

Riboflavin

Acetylsalicylic acid

Ibuprofen

Lactose

Cephalosphorin

Defined grinding or shredding occurs in the single-stage RFG granulating module made by Alexanderwerk.

Custom-made designs or special housings and individual adapta-tions to the WP 150 Pharma are available at any time.

Optionally, the WP 150 Pharma can be supplemented with an environment-friendly recooling unit.

1 Vent for displaced air and at the same time filler for undersize and/or oversize respectively

2 Filler for raw product

3 Nozzle for level sensor

4 Feeder hopper using the Combi-Vent-Feeder® design

5 Roller compactor compacting unit

6 Cake breaker for precrushing

7 Amply dimensioned single-stage granulating unit

8 Outer casing; behind it the worm feeder

9 Casing for the processing chamber, circumferentially welded to the back panel

10 Transparent cover for the processing chamber, gaskets in a containment design, bolted to eight handles made of stainless steel

11 Nozzle for sampling

12 Nozzle for granulate material outlet

13 Pivoted LCD touch screen as an operating unit

Alexanderwerk AG Kippdorfstraße 6 – 24 42857 Remscheid P+49 (0)2191 79 50 F +49 (0)2191 79 53 50 imaschinen@alexanderwerk.com www.alexanderwerk.comNo liability will be accepted for errors or omissions. Subject to change (246-2825)

Containment in Pharmaceutical Production

Compactors and GranulatorsWP 150 Pharma

Compactors and Granulators for use in the pharmaceutical Industry, made by Alexanderwerk

Roller Compactor BT 120 PharmaFor laboratory and special uses, with a throughput of up to 8 kg/hr.

Roller Compactor WP 120 PharmaA compactor and granulator for special products, frequent product changes and small batches, for use in the laboratory or the lower production range; with a throughput of up to 40 kg/hr.

Roller Compactor WP 150 PharmaA compactor and granulator for use in the pharmaceutical industry; with a throughput of up to 150 kg/hr.

Roller Compactor WP 200 PharmaA compactor and granulator for use in production; with a throughput of up to 250 kg/hr.

Roller Compactor WP 200 C1For highest requirements in pharmaceutical production; with a throughput of up to 250 kg/hr.

CAD data show the WP 150 Pharma

Technical Data

Throughput, continuous operation up to 150 kg/hr.

Granulate material size variable

Maximum pressing force 20 kN/cm of roller width

Installed power approx. 8 kW

Weight approx. 1,700 kg (complete, excluding control system)

Metallic materials 1.4571 (entirely)

Compacting rollers 1.4122

Rotary shaft seals, in contact with the material Polytetrafluoroethylene (PTFE, Teflon) FDA-approved

www.fa

berm

olde

nhau

er.de

Alexanderwerk AG Kippdorfstraße 6 – 24 42857 Remscheid P+49 (0)2191 79 50 F +49 (0)2191 79 53 50 imaschinen@alexanderwerk.com www.alexanderwerk.comNo liability will be accepted for errors or omissions. Subject to change (246-2825)

Containment in Pharmaceutical Production

Compactors and GranulatorsWP 150 Pharma

Compactors and Granulators for use in the pharmaceutical Industry, made by Alexanderwerk

Roller Compactor BT 120 PharmaFor laboratory and special uses, with a throughput of up to 8 kg/hr.

Roller Compactor WP 120 PharmaA compactor and granulator for special products, frequent product changes and small batches, for use in the laboratory or the lower production range; with a throughput of up to 40 kg/hr.

Roller Compactor WP 150 PharmaA compactor and granulator for use in the pharmaceutical industry; with a throughput of up to 150 kg/hr.

Roller Compactor WP 200 PharmaA compactor and granulator for use in production; with a throughput of up to 250 kg/hr.

Roller Compactor WP 200 C1For highest requirements in pharmaceutical production; with a throughput of up to 250 kg/hr.

CAD data show the WP 150 Pharma

Technical Data

Throughput, continuous operation up to 150 kg/hr.

Granulate material size variable

Maximum pressing force 20 kN/cm of roller width

Installed power approx. 8 kW

Weight approx. 1,700 kg (complete, excluding control system)

Metallic materials 1.4571 (entirely)

Compacting rollers 1.4122

Rotary shaft seals, in contact with the material Polytetrafluoroethylene (PTFE, Teflon) FDA-approved

www.fa

berm

olde

nhau

er.de