Colorless Carotenoids Combinations Colorless Carotenoids: Phytoene & Phytofluene Efficacy Protection and Stability Synergism Boosting activity TiO 2 &

Colorless Carotenoids Combinations

Colorless Carotenoids:Phytoene & Phytofluene

Efficacy Protection and Stability

SynergismBoosting activity

TiO2 & ZnO

CoQ10

DHADiHydroxyAcetone

Retinol

IBR-Dormin®Vitamin C

Squalene

Omega 3 oilsDHA & EPA

Carotenoids

www.ibrweb.com

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Efficacy Protection andStability Synergism

Boosting activity

TiO2 & ZnO

CoQ10

DHADiHydroxyAcetone

Retinol

IBR-Dormin ®Vitamin C

Squalene


Carotenoids


www.ibrweb.com

Phytoene and phytofluene •Beauty from the inside* and outside• Anti aging and photo-aging• Skin brightening/whitening – evening of skin tone• Protection against UV and its damage• Anti oxidant• Prevention of DNA damage• Anti inflammatory• Protection and enhancement of other active ingredients and their activity

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Boosting activity

CoQ10

DHADiHydroxyAcetone

Retinol


Squalene

Omega 3 oils

DHA & EPA

Carotenoids

Phytoene and phytofluene – TiO2 & ZnO•Stabilization•Boost of SPF*•Reduce generation of free radicals and damage derived from irradiation of TiO2 & ZnO

UV filterSPF in vitro

Predicted SPF

Increase

Phytoene 5%15.2

TiO2 5%1.3

Phytoene 2.5% +TiO2 2.5%

16.08.394%

*SPF in vitro : the average of five measurement

TiO2 & ZnO

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Boosting activity

CoQ10

DHADiHydroxyAcetone

Retinol


Squalene

Omega 3 oils

DHA & EPA

Carotenoids

Phytoene and phytofluene – TiO2 & ZnO•Stabilization•Boost of SPF•Reduce generation of free radicals and damage derived from irradiation of TiO2 & ZnO*

* UVA irradiated phenol stability

TiO2 & ZnO

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0

5

10

15

20

25

30

35

40

45

0.25% TiO2TiO2+0.01 mg/ml P&PTiO2+0.05 mg/ml P&P

% P

he

no

l aft

er

UV

A ir

rad

iati

on


CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone

Retinol


Squalene


Carotenoids

Phytoene & phytofluene – CoQ10•Stabilization and protection against degradation•Synergism:

1. Anti aging - reduced MMP-1 expression*2. Reduced inflammation – PGE-2*

•Anti oxidants – reduce fatigue & stress

*Fuller B.B., et al. J. Cos. Der.. 2006 March. 5(1):30

www.ibrweb.com

1. 2.

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CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone


Squalene


Carotenoids

Phytoene & phytofluene – Retinol

•Stabilization and protection against degradation

A. 5% Retinol + 0.5% Phytoene &

Phytofluene

B. 0.1% Retinol+0.05% Phytoene &

phytofluene

Retinol

Retinol left in cream after 4 weeks with0.5% Phytoene & Phytofluene or 0.05% BHT

93% 68%

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B

A

B

A

Time: 0 Time: 10 min

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CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone


Squalene


Retinol

Phytoene and phytofluene – -carotene

•Stabilization and protection against degradation•IBR-AAC® Anti Aging Carotenoids – phytoene, phytofluene and β-carotene: anti oxidation, anti inflammation, UV protection and pro-retinol addition

Carotenoids

www.ibrweb.com

After 35 minutes sun and air exposureStarting point

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CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone

Vitamin C

Retinol

Carotenoids

Squalene

IBR-Dormin ®

Phytoene and phytofluene – Omega 3 oils

• Stabilization and protection against degradation

Reduce peroxide number• Combined activities:

1. Prevention of LDL oxidation2. Anti aging- anti oxidants, anti

inflammatory and protection from UV damage

3. Reduced stretch marks and wrinkles via combined activity of induction of old collagen degradation and enhancement of new collagen synthesis (mostly due to phytoene and phytofluene benefits)

4. Skin protection


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CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone



Retinol

Carotenoids

Squalene

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Phytoene and phytofluene – squalene

• Stabilization and protection against degradation

Reduction in peroxide number• Activities:

1. Squalene boosts the phytoene and phytofluene protection against UVA and UVB and UV damage in general

2. Anti aging- via anti oxidation and protection from UV damage

Effect of phytoene & phytofluene and squalene on % peroxides formed in EPA exposed to air

0

20

40

60

80

100

120

EP

A

5%

SQ

ULE

NE

0.0

05

%

alg

al

PH

an

d P

F

0.0

1%

alg

al

PH

an

d P

F

0.0

03

7%

tom

ato

PH

and

PF

0.0

07

5%

tom

ato

PH

and

PF

Sq

uale

ne

5%

Sq

uale

ne

5%

+

0.0

02

5%

alg

al

PH

Sq

uale

ne

5%

+

0.0

05

%

alg

al

PH

Sq

uale

ne

5%

+

0.0

1%

alg

al

PH

% P

ero

xid

e c

rea

ted

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CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone

Vitamin C


Retinol

Carotenoids

Squalene

IBR-Dormin ®

Phytoene and phytofluene – IBR-Dormin®

• Complementary short and long term anti aging action

Colorless carotenoids- anti oxidants, UV and UV damage protectors, collagen balancing (old and new), prevention of damage to DNA.

IBR-Dormin® - slowing down aging via dormancy and slowdown of cell proliferation.

• Combined skin whitening/ brightening activity.Inhibition of melanocytes proliferation

and melanin synthesis

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©


CoQ10



Boosting activity

TiO2 & ZnO

DHADiHydroxyAcetone

Retinol

Carotenoids

Squalene

IBR-Dormin ®


Phytoene and phytofluene – vitamin C

• Mutual stabilization in emulsions• Activities:

1. Combined skin whitening/ brightening activity.

2. Oil soluble and water soluble anti oxidants combination

3. Reduced stretch marks and wrinkles via combined activity of induction of old collagen degradation and enhancement of new collagen synthesis

Vitamin C

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CoQ10



Boosting activity

TiO2 & ZnO

Retinol

Carotenoids

Squalene

IBR-Dormin ®


Vitamin C

DHADiHydroxyAcetone

Phytoene and phytofluene – DHA (di hydroxy acetone)

•Stabilization and protection against degradation•Anti oxidants – extending artificial sun tan

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Contact

www.ibrweb.com

Business Development and Marketing:

Liki von Oppen-Bezalel, Ph.D.

Hartmannsweilerweg 1, 14163 Berlin, Germany

Tel: +49-30-80589698; Fax: +49-30-80589704

email: [email protected]

Office:

Inon Perry, CEO

7 Jabotinsky st., Ramat-Gan 52520, Israel

Tel:+972-3-5165432; Fax:+972-3-5165654

email: [email protected]



Boosting activity

TiO2 & ZnO

CoQ10

DHADiHydroxyAcetone

Retinol


Squalene


Carotenoids

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease

©

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Colorless Carotenoids Combinations Colorless Carotenoids: Phytoene & Phytofluene Efficacy Protection and Stability Synergism Boosting activity TiO 2 &